Australian Public Assessment Report for sacubitril ...
The company states that equivalent valsartan exposure (AUC) needs to be from higher doses of the monotherapy Diovan (or generics), as the proposed ’50 mg’ product containing 26 mg (25.7 mg) valsartan is equivalent in vivo with a ‘Diovan’ dose for AUC of 40 mg, the proposed ‘100 mg’ product containing 51 mg (51.4 mg) valsartan is ... ................
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