Antibiotic Study Cheat Sheet June 9 - IDStewardship

Antibiotic Study Guide & Cheat Sheet

When You See... MSSA

MRSA

Enterococci Strep. pyogenes or Strep. agalactiae Strep. pneumoniae or Viridans Streptococci

Pseudomonas aeruginosa

Escherichia coli

Stenotrophomonas sp ESBL+ Enterobacteriaceae Carbapenem resistant

Anaerobes

Clostridium difficile Atypicals Candida albicans Candida krusei Aspergillus CMV HSV Cryptosporidium

Some drugs with activity... Oral: cephalexin dicloxacillin; IV: Oxacillin, nafcillin, cefazolin Oral: SMX/TMP, doxycycline, clindamycin (+/-), linezolid, tedizolid; IV: vancomycin, daptomycin, telavancin, dalbavancin, oritavancin, ceftaroline Ampicillin, then vancomycin, then linezolid (VRE), daptomycin (VRE), or tigecycline (VRE)

Penicillin, clindamycin

Ceftriaxone, levofloxacin, (check for penicillin and macrolide resistance) Oral: ciprofloxacin, levofloxacin; IV: piperacillin/tazobactam, ceftazidime, ceftazidimeavibactam, cefepime, ceftolozane-tazobactam, imipenem-cilastatin, meropenem, meropenemvaborbactam, aztreonam, aminoglycosides, polymyxins Oral: any oral cephs, amoxicillin-clavulanic acid, SMX/TMP, nitrofurantoin, fosfomycin, ciprofloxacin, levofloxacin; IV: ceftriaxone, ampicillin-sulbactam, cefepime, piperacillintazobactam, ertapenem SMX/TMP, levofloxacin Carbapenems, ceftolozane-tazobactam, ceftazidime-avibactam, meropenemvaborbactam, polymyxins, aminoglycosides, fosfomycin, fluoroquinolones ESBL+ drug list minus carbapenems Oral: Metronidazole, clindamycin, amoxicillinclavulanic acid, moxifloxacin; IV: ampicillinsulbactam, piperacillin-tazobactam, cefoxitin, cefotetan, ertapenem, tigecycline Oral vancomycin or fidaxomicin, metronidazole (less preferred) Macrolides, fluoroquinolones, tetracyclines

Fluconazole

Micafungin, anidulafungin, or caspofungin

Voriconazole PO: valganciclovir; IV: ganciclovir PO: acyclovir, valacyclovir; IV: acyclovir

Nitazoxanide

See This... Daptomycin Tigecycline Linezolid Cefepime

Ertapenem

Aztreonam Aminoglycoside monotherapy Rifampin Micafungin Fluconazole

With this... Beta-lactams SMX/TMP

Fluoroquinolones

Aminoglycosides Macrolides Tetracyclines Tigecycline Daptomycin

Linezolid

Vancomycin Rifampin Azoles Amphotericin B

Think NOT for... Pneumonia Bacteremia or Pseudomonas MRSA bacteremia Anaerobes, Enterococci Acinetobacter, Pseudomonas, Enterococci - "APE" Gram positives

Non-UTI indication

Monotherapy UTI or meningitis Candida krusei

Beware... GI upset, seizures Hyper-K+, allergy, myelosuppression QT prolong, CNS effects, tendon rupture, peripheral neuropathy, binding cations Ototoxicity, nephrotoxicity QT prolong Phototox., esophagitis Nausea/ vomiting CK elevation Thrombocytopenia, peripheral neuropathy, optic neuritis Nephrotoxicity Hepatotoxicity, DDIs Hepatotoxicity, DDIs Hypo-K, Hypo-Mg, infusion rxn, nephrotox

[Last updated June 2018]

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