Chem 454: Regulatory Mechanisms in Biochemistry University of ...
Lecture 5 - Oxidative Phosphorylation
Chem 454: Regulatory Mechanisms in Biochemistry University of Wisconsin-Eau Claire
Introduction
Oxidation and Phosphorylation are coupled by transmembrane proton fluxes:
Oxidation
Phosphorylation
2
1. Mitochondria
Oval-shaped organelles
0.5 ?m X 2 ?m
Contain
Citric acid cycle enzymes Fatty acid oxidation enzymes respiratory assembly
3
1.1 Structure of Mitochondria
Mitochondria are bound by a double membrane
4
2. Electron Transfer
The reoxidation of NADH and FADH2 by molecular oxygen is highly exergonic.
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