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Morphine undergoes glucuronidation to morphine-3-glucuronide (M3G, approximately 50%) and morphine-6-glucuronide (M6G, approximately 5 to 15%). Minor pathways of metabolism include sulfation to morphine-3-etheral sulfate and demethylation. M6G is an active metabolite, but has poor ability to cross the blood-brain barrier.1 ................
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