May 26, 1996
Joseph I. Shapiro, M.D., F.A.H.A., F.A.S.N., M.A.C.P.
Curriculum Vitae: December, 2018
Title:
Vice President and Dean, Joan C Edwards College of Medicine
Marshall University
Personal History:
Born 08/24/54, Newark, New Jersey
Citizenship United States
Marital Status Married
Address 131 Woodland Drive
Huntington, WV 25705
Home Telephone (419) 842-0079
Office Telephone (304) 691-1700
EMAIL shapiroj@marshall.edu
Education and Post Graduate Training:
University of Pennsylvania, B.A. Mathematics 9/72-6/76.
UMDNJ-New Jersey Medical School, M.D. 9/76-6/80.
Georgetown University: Residency in Internal Medicine 7/80-6/83.
University of Colorado: Fellowship in Renal Diseases 7/83-6/87.
Licensure:
Currently licensed in Ohio and WV.
Board Certification:
Internal Medicine (1983, maintained)
Nephrology (1986, maintained)
Faculty Positions:
University of Colorado: Director, Chronic Dialysis Service 1986-1991.
University of Colorado: Instructor in Medicine 1986-1987.
University of Colorado: Assistant Professor of Medicine 1987-1993.
University of Colorado: Co-Director NMR Spectroscopy 1989-1995.
University of Colorado: Co-Director Renal Transplant Physicians 1989-1997.
University of Colorado: Assistant Professor of Radiology 1989-1993.
Denver University: Adjunct Professor of Physics ` 1992-1997.
University of Colorado: Associate Professor of Medicine 1993-1997.
University of Colorado: Associate Professor of Radiology 1993-1997.
Denver VAMC: Director, Renal Transplant Service 1995-1997.
Denver VAMC: Section Head, Renal Diseases 1996-1997.
University of Toledo (formerly Medical College of Ohio at Toledo):
Professor of Medicine & Physiology/Pharmacology 1997-2012.
University of Toledo: Renal Division Head 1997-1999.
University of Toledo: Interim Chairman of Medicine 1999-1999.
University of Toledo: Chairman of Medicine 1999-2012.
University of Toledo: Interim Chairman of Physiology 2004-2005.
University of Toledo: Associate Dean for Business Development 2006-2012.
University of Toledo Physicians, President 2011-2012.
Marshall University: Vice President and Dean,
College of Medicine 2012-present
Marshall University: Professor of Medicine 2012-present
Peer Review:
Editorial Board:
Kidney International 2002-2005, 2005-2012.
Frontiers in Bioscience 2002-present.
Biological Research in Nursing 2002-present.
American Journal of Medicine 2005-present.
American Society for Artificial Internal Organs 2005-present.
Arterial’naya Gipertenziya – The Arterial Hypertension 2006-present.
International Journal of Hypertension 2009-present
Journal of Signal Transduction 2010 - present
Hypertension 2010 – 2012
Recent Patents on Biomedical Engineering 2010-present
Chinese Journal of Clinicians 2010 – present
World Journal of Hypertension 2011-present
Journal of the American Heart Association 2011-present (Associate Editor)
World Journal of Clinical Urology 2011-present
Physiology Journal 2012-present
West Virginia Journal 2012-present (Associate Editor)
Journal of Hypertension Open Access 2012-present (Editor in Chief)
Cureus (2012-2016)
International Journal of Medical and Clinical Research 2013-present (Associate Editor)
Translational Genetics and Genomics 2-16-present (Associate Editor)
Have reviewed journal articles for other peer review journals including: AJKD, American Journal of Nephrology, AJP, ASAIO, Chest, Circulation, Circ Research, Crit Care Research, Dialysis and Transplantation, Embo J, Hypertension. JASN, J Cellular Phys, J Clin Invest, J Crit Care, J Hypertension, J Mol Cel Card, J Ped Res, J Reprod, Placenta, Nature, Nephron, PNAS, Renal Failure, Science, Science Advances, Scientific Reports, Transplantation and Transplantation Proceedings
Have reviewed grant applications for National Institutes of Health (ad hoc 1992, 1994, 2014), European Commission (2004), American Heart Association (1992-97, 98-2001, 2002-2003), National Kidney Foundation (2002), Arizona Disease Control Foundation (1997, 2000), Michigan Kidney Foundation (1998,2000), Veterans Administration (ad hoc, 1997) and DoD (2015, chairman 2015, 2017), Austrian Research Foundation (2016, 2017).
Have reviewed abstracts for AFCR (national and western), SMRM as well as ASN meetings (1993, ARF, 1995 Acid-base, 1999-hemodialysis hemodynamics, selection chairman). Member ASN Finance Committee (2002-2007). Member AHA – Kidney in Cardiovascular Disease (KCVD) Council (2009-2012, Membership Committee Chairman 2012-2012).
Domestic Patents and Full Applications:
Apparatus and methods for analyzing heart sounds
Patent number: 5687738
Type: Grant
Filed: July 3, 1995
Date of Patent: November 18, 1997
Assignee: The Regents of the University of Colorado
Inventors: Joseph Isaac Shapiro, Howard David Weinberger
Apparatus and methods for analyzing body sounds
Patent number: 5957866
Type: Grant
Filed: November 15, 1996
Date of Patent: September 28, 1999
Assignee: University Technology Corporation
Inventors: Joseph Isaac Shapiro, Howard David Weinberger
Na/K-ATPase Ligand
Publication number: 20140128356
Type: Application
Filed: March 25, 2013
Publication date: May 8, 2014
Applicant: The University of Toledo
Inventors: Zi-Jian Xie, Joseph I. Shapiro
Na/K-ATPase Ligand and Uses Thereof in Wound Healing
Publication number: 20150342966
Type: Application
Filed: July 6, 2015
Publication date: December 3, 2015
Applicant: The University of Toledo
Inventors: Zi-Jian Xie, Joseph I. Shapiro
Na/K-ATPase ligand
Patent number: 9072751
Type: Grant
Filed: March 25, 2013
Date of Patent: July 7, 2015
Assignee: The University of Toledo
Inventors: Zi-Jian Xie, Joseph I. Shapiro
Na/K-ATPase ligand and uses thereof in wound healing
Patent number: 9492463
Type: Grant
Filed: July 6, 2015
Date of Patent: November 15, 2016
Assignee: The University of Toledo
Inventors: Zi-Jian Xie, Joseph I. Shapiro
Albumin-based colloid composition and method of use in treating hypovolemia and multiorgan dysfunction
Publication number: 20100004178
Type: Application
Filed: September 10, 2009
Publication date: January 7, 2010
Inventors: Ragheb Assaly, John D. Dignam, Joseph I. Shapiro
Na/K-ATPase Ligands, Ouabain Antagonists, Assays and Uses Thereof
Publication number: 20120302630
Abstract: Na/K-ATPase/Src ligands, assays and uses thereof are disclosed.
Type: Application
Filed: September 9, 2010
Publication date: November 29, 2012
Applicants: CHINESE ACADEMY OF MEDICAL SCIENCES, UNIVERSITY OF TOLEDO
Inventors: Zi-Jian Xie, Joseph I. Shapiro, Shuyi Si, Zhongbing Zhang
Albumin-based colloid composition and method of use in treating hypovolemia and multiorgan dysfunction
Publication number: 20030004105
Type: Application
Filed: March 26, 2002
Publication date: January 2, 2003
Inventors: Ragheb A. Assaly, John D. Dignam, Joseph I. Shapiro
Na/K-ATPase-derived peptide Src inhibitors and ouabain antagonists and uses thereof
Patent number: 9226952
Type: Grant
Filed: March 3, 2014
Date of Patent: January 5, 2016
Assignee: The University of Toledo
Inventors: Zi-Jian Xie, Zhichuan Li, Joseph I. Shapiro
NA/K-ATPASE-DERIVED PEPTIDE SRC INHIBITORS AND OUABAIN ANTAGONISTS AND USES THEREOF
Publication number: 20140187484
Type: Application
Filed: March 3, 2014
Publication date: July 3, 2014
Applicant: THE UNIVERSITY OF TOLEDO
Inventors: Zi-Jian Xie, Zhichuan Li, Joseph I. Shapiro
Assays and Cell-Based Tests Using a Receptor Na/K-ATPase/Src Complex and Uses Thereof
Publication number: 20150233925
Type: Application
Filed: May 8, 2013
Publication date: August 20, 2015
Applicant: THE UNIVERSITY OF TOLEDO
Inventors: Zi-Jian Xie, Joseph I. Shapiro, Fangfang Lai
Na/K-ATPase Ligand
Publication number: 20090226513
Type: Application
Filed: January 30, 2007
Publication date: September 10, 2009
Inventors: Zijian Xie, Joseph I. Shapiro
Albumin-based colloid composition and method of use in treating hypovolemia and multiorgan dysfunction
Patent number: 7037895
Type: Grant
Filed: March 26, 2002
Date of Patent: May 2, 2006
Assignee: Medical College of Ohio
Inventors: Ragheb Assaly, John D. Dignam, Joseph I. Shapiro
NaK-ATPase-Derived Peptide SRC Inhibitors and Ouabain Antagonists and Uses Thereof
Publication number: 20110245167
Type: Application
Filed: December 14, 2009
Publication date: October 6, 2011
Applicant: THE UNIVERSITY OF TOLEDO
Inventors: Zi-Jian Xie, Zhichuan Li, Joseph I. Shapiro
Albumin-based colloid composition and method of use in treating hypovolemia and multiorgan dysfunction
Patent number: 7348312
Type: Grant
Filed: March 22, 2006
Date of Patent: March 25, 2008
Assignee: Medical College of Ohio
Inventors: Ragheb Assaly, John D. Dignam, Joseph I. Shapiro
Albumin-based colloid composition and method of use in treating hypovolemia and multiorgan dysfunction
Patent number: 7605130
Type: Grant
Filed: November 6, 2007
Date of Patent: October 20, 2009
Assignee: Medical College of Ohio
Inventors: Ragheb Assaly, John D. Dignam, Joseph I. Shapiro
Na/K-ATPase ligand
Patent number: 8906891
Type: Grant
Filed: January 30, 2007
Date of Patent: December 9, 2014
Assignee: The University of Toledo
Inventors: Zijian Xie, Joseph I. Shapiro
Albumin-based colloid composition having at least one protected thiol region, methods of making, and methods of use
Publication number: 20080247958
Type: Application
Filed: January 22, 2008
Publication date: October 9, 2008
Inventors: Ragheb A. Assaly, J. David Dignam, Joseph I. Shapiro
Na/K-ATPase ligands, ouabain antagonists, assays and uses thereof
Patent number: 9114126
Type: Grant
Filed: October 3, 2013
Date of Patent: August 25, 2015
Assignee: THE UNIVERSITY OF TOLEDO
Inventors: Zi-Jian Xie, Joseph I. Shapiro, Shuyi Si, Zhongbing Zhang
Albumin-based colloid composition having at least one protected thiol region, methods of making, and methods of use
Patent number: 7884068
Type: Grant
Filed: November 9, 2004
Date of Patent: February 8, 2011
Inventors: Ragheb A. Assaly, J. David Dignam, Joseph I. Shapiro
Na/K-ATPase Ligands, Ouabain Antagonists, Assays and Uses Thereof
Publication number: 20150272923
Type: Application
Filed: June 11, 2015
Publication date: October 1, 2015
Applicant: The University of Toledo
Inventors: Zi-Jian Xie, Joseph I. Shapiro, Shuyi Si, Zhongbing Zhang
Peg-albumin composition having at least one protected thiol region as a platform for medications
Publication number: 20120010144
Type: Application
Filed: April 2, 2010
Publication date: January 12, 2012
Inventors: Ragheb Assaly, John David Digman, Joseph I Shapiro
Na/K-ATPase Ligands, Ouabain Antagonists, Assays and Uses Thereof
Publication number: 20140031419
Type: Application
Filed: October 3, 2013
Publication date: January 30, 2014
Applicant: The University of Toledo
Inventors: Zi-Jian Xie, Joseph I. Shapiro, Shuyi Si, Zhongbing Zhang
Albumin-based colloid composition having at least one protected thiol region, methods of making, and methods of use
Patent number: 7345150
Type: Grant
Filed: October 25, 2005
Date of Patent: March 18, 2008
Assignee: Medical University of Toledo
Inventors: Ragheb A. Assaly, J. David Dignam, Joseph I. Shapiro
Na+/K+-ATPase-specific peptide inhibitors/activators of Src and Src family kinases
Patent number: 8981051
Type: Grant
Filed: September 24, 2012
Date of Patent: March 17, 2015
Assignee: The University of Toledo
Inventors: Zi-Jian Xie, Joseph I. Shapiro, Jiang Tian, Zhichuan Li
NA+K+-ATPase-Specific Peptide Inhibitors/Activators of SRC and SRC Family Kinases
Publication number: 20100056446
Type: Application
Filed: October 31, 2007
Publication date: March 4, 2010
Applicant: THE UNIVERSITY OF TOLEDO
Inventors: Zijian Xie, Joseph I. Shapiro, Jiang Tian
Na+/K+-ATPase-Specific Peptide Inhibitors/Activators of Src and Src Family Kinases
Publication number: 20150133389
Type: Application
Filed: January 28, 2015
Publication date: May 14, 2015
Applicant: THE UNIVERSITY OF TOLEDO
Inventors: Zi-Jian Xie, Joseph I. Shapiro, Jiang Tian, Zhichuan Li
Na+K+-ATPase-specific peptide inhibitors/activators of SRC and SRC family kinases
Patent number: 8283441
Type: Grant
Filed: October 31, 2007
Date of Patent: October 9, 2012
Assignee: University of Toledo
Inventors: Zijian Xie, Joseph I. Shapiro, Jiang Tian
Board Memberships
American Heart Association of Toledo: Board of Directors Member (2007-2012), President (2011-2012).
Regional Growth Partnership of NW Ohio: Scientific Advisory Board Member (2007-2012).
ADS-Biotechnology: Board of Managers Chairman (2008-2013).
Alliance for Paired Donation Board of Directors Member (2008-present).
Promedica Health Systems Academic Health Center Board of Managers (2010-2012).
Oxosi Pharmaceuticals (Founding Board Member, 2016-present)
Mountain Health (Founding Board Member, 2018-present)
Spin Off Companies
SeeHear LLC (1992-1997, 1.5M in investment capitalization)
Developed Graphical Electronic Stethoscope
ADS-Biotechnology, LLC (> 1M in investment capitalization)
Developed Pegylated Albumin as therapy for capillary leak
Oxosi Pharmaceuticals, LLC
Platform of products based on Na/K-ATPase signaling
Grant Support (dollar amounts are approximate direct costs):
Principal Investigator:
N.I.H. NRSA (1985-87) Energy Metabolism in Acute Renal Failure. L. Chan, Sponsor ($60,000).
American Heart Association Clinician Scientist Award (1988-92) NMR spectroscopy studies of systemic acidosis. R.W.Schrier, Sponsor. ($250,000).
Colorado Heart Association Beginning Grant in Aid (1988-89, 89-90, 90-91) NMR studies of systemic acidosis (Total $65,000).
Knoll Pharmaceuticals (1991-93) Use of a combination calcium channel blocker and ACE inhibitor in the progression of chronic renal failure ($100,000).
US Army Medical Research (1990-92) Interactions between hypoxia and acidosis: Implications for treatment of battlefield trauma. Co-PI R. Kucera ($80,000).
Amgen Inc. Effect of erythropoetin on iron metabolism in ESRD patients. (1991-93). Co-PI P. Seligman. ($80,000)
American Heart Association Established Investigator Award (1992-97) Energy metabolism during acidosis. ($300,000).
Somatogen Inc. (1993-94) NMR studies of recombinant hemoglobin in the isolated heart. ($30,000).
University Hospital. (1994-95) Treatment of hypertension in a managed care population Co-PIs M. Shapiro and C. Yucha ($28,000).
Merck and Company. (1994-95) Matching Educational Grant Co-PIs M. Shapiro and C. Yucha ($28,000).
Colorado Heart Association Standard Grant in Aid. (1996-98) Energetic effects of potassium depletion ($60,000).
Merck and Company (1996-2001). Study of Losartan in the treatment of Type II Diabetic Nephropathy. Co-PI A. Alfrey ($100,000).
Allos Therapeutics: Investigation into the mechanisms by which an allosteric modulator of hemoglobin saturation influences experimental acute renal failure. (1995-97) Co-PI T.J. Burke ($65,000).
N.I.H. The National Analgesic Study Grant N01-DK-0-2400. (1999-2004) 3.5M. Direct Costs. JI Shapiro, PI. Multi-center trial examining the prevalence of analgesic nephropathy.
N.IH. Contract (263-MA707136-1, 2008-2010). $100,000 Direct Costs. JI Shapiro and D Malhotra Co-PIs. Single center pilot study examining effect of Digibind on blood pressure and oxidant stress in hemodialysis patients.
N.I.H. RO1 (HL109015, 2011-2015) $450,000-500,000/year Direct Costs. JI Shapiro and Z Xie Co-PIs. Receptor Na/K-ATPase Antagonists As Novel Therapeutics For Renal/Cardiac Diseases.
Youbo Pharmaceuticals. 2012-2015 $250,000 Total Costs. JI Shapiro and Z Xie Co-PIs. Active component s of Shuxutong.
New Chapter, Inc. 2012-2015. $25,000 Total Costs. JI Shapiro and J Liu Co-PIs. Dermal production of collagen in response to cardiotonic steroids.
Corvidia Pharmaceuticals. 2016-17. Effect of IL6Ab in uremic cardiomyopathy. JI Shapiro and J Liu Co-PIs. Total costs approximately $100,000.
Co-Principal Investigator:
Knoll Pharmaceuticals (1987-89) Prevention of the progression of chronic renal insufficiency with calcium channel blockers. PI: Robert W. Schrier, M.D., Dept. of Medicine, University of Colorado Health Sciences Center ($120,000).
American Heart Association (1987-90). Detection of cardiac graft rejection with NMR spectroscopy. PI: Laurence Chan, M.D., Dept. of Nephrology, University of Colorado Health Sciences Center ($135,000).
Colorado Heart Association (1990-91, 91-92 and 92-93). Monitoring of cytosolic sodium with Na NMR spectroscopy. PI: Robert Hutchison, Ph.D., Privately Employed ($60,000).
Amgen Inc. Effect of erythropoetin on muscle energy metabolism in ESRD patients. (1991-93). PI: L. Chan, M.D. ($40,000)
Whitaker Foundation (1993-96). Construction of a probe for NMR studies of Cell Suspensions. PI: R. Hutchison, Ph.D. ($180,000).
N.I.H. Physician Scientist Award (1993-98). Evaluation of muscle cell energetics with 31P NMR spectroscopy; implications for rehabilitation. PI: Michael Blei, M.D., Dept. of Rehabilitation, University of Colorado Health Sciences Center. Co-Sponsor with L. Chan ($350,000).
N.I.H. Physician Scientist Award (1995-2000) Role of creatine kinase isoforms in cardiac energy metabolism. PI: Howard Weinberger, M.D., Dept. of Cardiology, Univ. of Colorado Health Sciences Center. Co-Sponsor with M. Benjamin Perryman ($350,000).
N.I.H. Academic Investigator Award (1995-98) Role of the sympathetic nervous system in essential hypertension. PI: C. Yucha, Ph.D., R.N., Assoc. Dean for Research, Univ. of Florida School of Nursing. Co-Sponsor with S. Linas ($210,000).
Allos Therapeutics: Effect of an allosteric modulator of hemoglobin saturation on experimental acute renal failure. PI: T.J. Burke, M.D., Dept. of Medicine, Univ. of Colorado ($20,000).
Colorado Heart Association (1996-97) Role of creatine kinase isoforms in cardiac energy metabolism. PI: H. Weinberger ($20,000).
N.I.H. SCOR (1996-1999) Impact of Injury on the Immature Pulmonary Circulation Grant# 1P50HL57144-01 Project 4: Oxidants, Energy and Pulmonary Vascular Development. PI: Carl White, M.D., Dept. of Pediatrics, Univ. of Colorado ($550,000).
N.I.H. RO1 (2000-2004) Role of sodium pump in cardiac hypertrophy. HL63238. PI: Zijian Xie, Ph.D., Dept. of Pharmacology, Medical College of Ohio, Co-PI: JI Shapiro ($800,000).
US Army (2001-2004) Use of pegylated albumin as a volume expander in systemic capillary leak. PI: Ragheb Assaly, M.D., Pulmonary/Critical Care Medicine, Medical College of Ohio. Co-PI: JI Shapiro (approx $750,000 total)
N.I.H. RO1 (2002-2007) Role of ROS in uremic cardiomyopathy. HL67963.PI: Zijian Xie, Ph.D. Department of Pharmacology, Medical College of Ohio. Co-PI: JI Shapiro (approx $1,000,000).
Centicor Corporation (2002-2006). RESIST. PI Christopher Cooper, Co-Investigator and PI for core lab, JI Shapiro, M.D. (approx 300,000 per year).
N.I.H. RO1 (2004-2012) Cardiovascular outcomes in renal atherosclerotic lesions (CORAL). PI Christopher Cooper, M.D., HL071556, National enrollment committee chairman and site co-PI, JI Shapiro, M.D. (approx 2. 7M per year).
N.I.H. RO1 (2011-2016, 250K per year.).Na/K-ATPase reduction in renal disease-related cardiac dysfunction. PI – Jiang Tian, PhD, Co-I JI Shapiro, MD. HL105649.
N.I.H. SMARRT Award (2017-2019). Modification of pNaKtide for clinical application. PI – Zijian Xie, PhD, Co-PI JI Shapiro, MD.
Honors and Awards:
Pi Mu Epsilon (Mathematics honor society, 1974)
Graduated University of Pa. Magna cum Laude with distinction in Mathematics (1976).
University of Medicine and Dentistry of New Jersey: Alpha Omega Alpha (1980).
Georgetown University: Dudley P. Jackson Award (1983).
NIH fellowship award (1985-87).
American Heart Clinician-Scientist Award (1988-92).
American Heart Association Established-Investigator Award (1992-97).
Western Society for Clinical Investigation (1992).
Medical College of Ohio Internal Medicine Faculty Teaching Award (1998).
Central Society for Clinical Investigation (2000)
American Society of Nephrology (1999). Chairman, Dialysis Hemodynamics Abstract Selection Committee.
American Heart Association – Hypertension Fellow (2001).
American Heart Association – Kidney Disease Fellow (2001)
Fellow of the American College of Physicians (2001).
Arnold P. Gold – Healthcare Foundation of New Jersey Humanism in Medicine Award (2002).
Mercy Health Partners-Northern Region Endowed Chair of Excellence in Internal Medicine Education (2003).
Fellow of the American Society of Nephrology (2004).
St. Vs- UT Internal Medicine Excellence in Education Award (2009).
America’s Top Doctors (2009-present).
America’s Best Doctors (2009-present).
Castle Connolly Top Doctors (2012-present).
Phi Kappa Phi Honor Society (2013-present).
American Physiological Society Cardiovascular Fellow (2013-present).
Laurence Chan Endowed Lectureship. 2014 (Inaugural Lecture).
Harold J. Jeghers Memorial Lecture. 2015.
Immunization Society of WV. 2017.
Charleston-Institute Alumnae Diversity Award 2018.
Master, America College of Physicians (MACP, Elected 2018 Induction 2019).
Society Memberships:
Society of Magnetic Resonance in Medicine
International Society of Nephrology
American Society of Nephrology (National Finance Committee, 2004-2006)
Colorado Society of Nephrology
American Association for the Advancement of Science
American College of Physicians
Western Society for Clinical Investigation
Central Society for Clinical Investigation
American Heart Association – Kidney in Cardiovascular Disease Council (Vice Chairman, 2007-2008)
American Heart Association – High Blood Pressure Research Council
American Society of Nephrology – Chronic Kidney Disease Advisory Group (2010-2015)
Association of Professors of Medicine
Association of Program Directors in Internal Medicine
American Medical Association
West Virginia State Medical Association
Southern Society for Clinical Investigation
American Society for Artificial Internal Organs
American Association of Transplant Physicians
Faculty Row
Cardiovascular Nexus
Institutional Teaching Activities:
University of Colorado
1981-1983 Clinical teaching as a resident/Dudley P. Jackson award as outstanding teaching resident (Georgetown University Hospital, 1983)
1984-1985 Active in ward teaching as a clinical Nephrology fellow (University of Colorado Hospital)
1985-1993 Small Group Section Group Leader, Renal Pathophysiology Course (University of Colorado). Participated in course design and implementation.
1986-1995 Course Director, Dialysis/Transplantation Core Lecture Series (University of Colorado). Wrote syllabus and organized mini-course for Nephrology fellows.
1993-1997 Overall Course Director, Renal Pathophysiology Course (University of Colorado). Wrote syllabus, designed course and examination for 2nd year med students.
1988-1997 Clinical Teaching, Nephrology Consult Service (University Hospital, University of Colorado). Taught 4th year med students, residents and fellows during out and inpatient clinical Nephrology service.
1988-1998 Clinical Teaching, Darley Internal Medicine Service (University Hospital, University of Colorado). (Taught 3rd and occasionally 4th year med students, residents and fellows during out and inpatient clinical internal medicine service.
1988-1995 Course Director, Clinical Case Nephrology Conference (University of Colorado). Developed and maintained weekly conference consisting of resident and fellow case presentations with group discussion.
1992-1997 Conference Director, City Wide Nephrology Rounds (University of Colorado). Organized and maintained a monthly conference schedule involving faculty and trainees of the University of Colorado along with private Nephrology attendings practicing in and around the city of Denver.
University of Toledo (formerly Medical College of Ohio)
1997- present Clinical Teaching, Med V Service.
Taught 3rd and 4th year medical students as well as interns, residents and fellows during clinical nephrology/internal medicine service. Won Faculty Teaching Award, 1997-98.
1997- 2012 Dialysis attending.
1997-2012 Outpatient clinics.
1997-2012 Transplant nephrology attending (back up).
1997-2012 Systems Course Planning/Action Committee (MCO).
Participated in the development and implementation of the new systems course.
1997- 2012 Renal System Planning/Action Sub-committee (MCO).
Participated in the specific development and implementation of the renal section of the new systems course.
1997-2012 Renal core curriculum lectures and conferences for students and residents.
1997-2012 Renal journal clubs.
1997- 2012 Medical Grand Rounds.
1997-2012 Physiology course lecture.
1997-2012 Physician Assistant program lecture.
1997-2012 Physical diagnosis course.
1997-2012 Renal Grand Rounds.
1997-2012 Renal Fellowship Program.
Restarted renal fellowship program at MCO. Recruited fellows, developed and implemented curriculum for fellowship program.
1998- 2012 Pathophysiology Section Leader (MCO)
Pathophysiology small group facilitator during the fall of 1998 in the new pathophysiology course for 1st year med students.
1999- 2012 Residents’ Morning Report (MCO)
Morning report from residents each week at MCOH.
1999-2012 Chairman’s Rounds (MCO)
Special teaching rounds with 3rd and 4th year students at MCOH each month.
1999- 2012 Professor’s Rounds (St. Vincent’s Hospital)
Special teaching rounds with 3rd and 4th year med students as well as residents and fellows at St. Vincent’s Hospital approximately every 3-4 weeks.
2001-2006 Mini-med school (course director)
Oversee annual series of medical seminars for lay public.
Invited Lectureships:
University of Colorado. 1987. Renal Grand Rounds. Alkalization therapy of metabolic acidosis.
University of Colorado. 1988. Medical Grand Rounds. Biomedical Applications of NMR
Spectroscopy.
Aspen Renal Conference. 1988. Obstructive Uropathy.
Aspen Renal Conference. 1990. Treatment of Metabolic Acidosis.
US Army Conference on ICU Care, Ft. Gordon, Ga. 1991. Pathogenesis and treatment of metabolic acidosis.
Aspen Renal Conference. 1992. Clinical-pathological case studies of renal transplant patients.
University of Arizona.1992. Medical Grand Rounds: Alkalization therapy of metabolic acidosis.
University of California at Los Angeles-Cedar Sinai Medical Center. 1992. Renal Grand Rounds. Alkalization therapy of metabolic acidosis.
American Society of Nephrology 1993. Therapy of anion-gap metabolic acidosis.
Washington Hospital Center Symposium on ICU Care 1994. (Washington, Pennsylvania). New treatments in acute renal failure.
University of Colorado. 1993. Medical Grand Rounds. Alkalization therapy of metabolic acidosis.
Fitzimmons Army Medical Center. 1993. Pathogenesis and treatment of metabolic alkalosis.
Association of Dialysis Nurses and Technicians Annual Meeting. 1994. Prescription dialysis based on urea kinetics; is this approach rational?
US Navy at Bethesda Naval Hospital. 1995. Alkalization therapy as part of fluid resuscitation.
Medical College of Ohio. 1996. Medical Grand Rounds. Alkalization therapy of metabolic acidosis.
American Society of Nephrology. 1996. Acid-base disturbances in liver disease.
Medical College of Ohio. 1997. Medical Grand Rounds. Acid-base disturbances associated with liver disease.
Washington University (St. Louis, MO). 1997. Renal Grand Rounds. Effects of hypokalemia on cardiac energetics and function.
University of Colorado. 1997. Renal Grand Rounds. Energetic effects of hypokalemia.
Aspen Renal Conference. 1997. Acid-base disturbances associated with liver disease.
Breckenridge Controversies in Transplantation Conference. 1998. Acid-base disturbances associated with liver transplantation.
Roche Symposium on Hypertension Therapy (Troy, Michigan). 1998. Effects of hypokalemia on cardiac energetics and growth.
Medical College of Ohio. 1998. Medical Grand Rounds. Effects of hypokalemia on cardiac metabolism, function and growth.
The Toledo Hospital. 1998. Medical Grand Rounds. Effects of hypokalemia on cardiac metabolism, function and growth.
Medical College of Ohio. 1998. College Research Conference. Effects of hypokalemia on cardiac energetics and growth.
Medical College of Ohio. 1998. Renal Grand Rounds. Urea kinetics: What do they mean?
St. Vincent’s Hospital. 1999. Ob-gyn Grand Rounds. Water metabolism in women; what every obstetrician/gynecologist needs to know.
Medical College of Ohio. 1999. Medical Grand Rounds. Effects of sodium pump inhibition on cardiac function and growth.
University of Colorado. 2000. Renal Grand Rounds. Uremic Cardiomyopathy.
George Washington University. 2000. Physiology Grand Rounds. Uremic Cardiomyopathy: new look at an old disease.
Merck "Cyberlecture Series": Treatment of Type II Diabetes: Focus on Dyslipidemia.
Medical College of Ohio. Medicine Grand Rounds. 2000. Uremic Cardiomyopathy: new look at an old disease.
Medical College of Ohio Symposium on Diabetes. 2000. Diabetic Nephropathy.
University of Colorado. 2001. Uremic Cardiomyopathy: New Look at an Old Disease.
Ohio Chapter ACPASIM Annual Scientific Mtg., Cleveland, OH. 2001. “Meet the Professor” session.
Henry Ford Hospital. 2001. Detroit, MI. Uremic Cardiomyopathy: New Look at an Old Disease.
Medical College of Ohio. 2001. Mini Med School lecture series. Body Chemistry, Blood Pressure.
Medical College of Ohio. 2001. Medicine Research Conference. Induction of sodium pump internalization of cardiac glycosides in proximal tubule cells.
MCP Hahnemann University, 2001. Renal Grand Rounds. Regulation of Proximal Tubule NaK-ATPase Activity by Digitalis Like Substances.
MCP Hahnemann University, 2001. Medicine Grand Rounds. Uremic Cardiomyopathy: New Look at an Old Disease.
National Institutes of Health (National Institute of Aging – Cardiovascular Division), 2002. Invited Lecture: Regulation of Proximal Tubule NaK-ATPse by Digitalis Like Substances.
Medical College of Ohio. 2002. Mini Med School lecture series. Body Chemistry, Blood Pressure.
Cincinnati ACP Meeting. 2002. Water Metabolism in Women.
University of Cincinnati. 2002. Medicine Grand Rounds. Uremic Cardiomyopathy: New Look at an Old Disease.
Breckenridge Transplant Conference. 2003. Cardiac disease in renal transplant recipients.
Beijing University. 2003. Renal Grand Rounds. Uremic Cardiomyopathy: New Look at an Old Disease.
Shanghai University. 2003. Renal Grand Rounds. Uremic Cardiomyopathy: New Look at an Old Disease.
Medical College of Ohio. 2003. Mini Med School lecture series. Body Chemistry, Blood Pressure.
Medical College of Ohio. 2003. Medicine Grand Rounds. Uremic Cardiomyopathy: New Look at an Old Disease.
St. Vincent Mercy Medical Center. 2003. Core Curriculum. Acute Renal Failure.
Medical College of Ohio. 2004. Department Research Conference. Endocytosis of the sodium pump in response to digitalis glycosides.
Ohio State University. Cardiology Grand Rounds. Uremic Cardiomyopathy.
Medical College of Ohio. 2004. Pathology Grand Rounds. Uremic Cardiomyopathy: New Look at an Old Disease.
Medical College of Ohio. 2004. Mini Med School lecture series. Body Chemistry, Blood Pressure.
Medical College of Ohio. 2004. Translational Research Symposium. Endocytosis of the Na/K-ATPase in response to cardiotonic steroids.
Medical College of Ohio. 2005. Medicine Research Conference. Uremic Cardiomyopathy.
Medical College of Ohio. 2005. Ob/Gyn Grand Rounds. Water Metabolism in Women.
University of Colorado. 2005. Renal Grand Rounds. Uremic Cardiomyopathy.
Copper Mountain CME Update for Family Medicine. 2005. Hypertension; current concepts.
Medical College of Ohio. 2004. Mini Med School lecture series. Body Chemistry, Blood Pressure.
Copper Mountain CME Update for Family Medicine. 2005. Role of renal failure in cardiovascular disease.
Tulane University. 2005. Medicine Grand Rounds. Uremic Cardiomyopathy.
Korotkov Symposium on Hypertension, St. Petersburgh, Russia. 2005. Role Of Digitalis Like Substances In The Pathogenesis Of Uremic Cardiomyopathy.
University of Michigan. 2005. Renal Grand Rounds. Uremic Cardiomyopathy.
Fourth World Congress of Cellular and Molecular Biology. Poitiers, France. 2005. Role of Cardiotonic Steroids in the Pathogenesis of Cardiac Fibrosis.
Medical University of Ohio. 2005. 17th Annual Cardiovascular Disease Symposium. Renal and Heart Disease: An Emerging Connection.
West Virginia University. 2006. Medicine Grand Rounds. Uremic Cardiomyopathy.
CORAL Investigators’ Meeting (Nashville, Tennessee, 2006). Challenges in patient enrollment.
CORAL Investigators’ Meeting (Melbourne, Australia) 2007. Challenges in patient enrollment.
CORAL Investigators’ Meeting (Auckland, New Zealand) 2007. Challenges in patient enrollment.
Breckenridge Transplant Conference (Breckenridge, Colorado) 2007. Recurrent renal disease as a cause of graft loss.
University of Toledo Health Science Campus. 2007. Surgery Grand Rounds. Digitalis – New Insights and Applications.
University of Toledo Health Science Campus. 2007. Medicine Research Conference. Uremic Cardiomyopathy.
Toledo Vascular Symposium. 2008. Treatment of ischemic vascular disease.
Medical University of South Carolina. 2008. Renal vascular disease; the case for the CORAL study.
University of Cincinnati. 2008. Renal vascular disease; the case for the CORAL study.
University of Toledo Health Science Campus. 2008. Medicine Grand Rounds. Uremic Cardiomyopathy.
Medical College of Wisconsin. 2008. Renal Grand Rounds. Uremic Cardiomyopathy.
Mercy Gilbert Medical Center. 2008. Cardiology Grand Rounds. Ischemic Nephropathy.
Akron General Hospital. 2009. Cardiology Grand Rounds. Ischemic Nephropathy: The CORAL Trial.
University of Toledo. 2009. Medicine Research Conference. Mechanism of action of spironolactone in the treatment of cardiac fibrosis.
Baxter Healthcare Inc. 2009. Development and Use of Pegylated Albumin for Capillary Leak.
Brown University. 2009. Spironolactone in Ischemic Renal Disease.
University of Toledo. 2009. Medicine Grand Rounds. Uremic Cardiomyopathy.
CORAL2 Planning Committee (Held in Toledo, OH) 2009. Cardiotonic Steroids and Ischemic Renal Disease.
University of Colorado. 2009. Renal Grand Rounds. Role of Cardiotonic Steroids in Natriuresis, Hypertension and Renal Fibrosis: Update on 3rd Factor.
University of Toledo Medical Grand Rounds. 2010. Role of Cardiotonic Steroids in Natriuresis, Hypertension and Renal Fibrosis: Update on 3rd Factor.
Breckenridge Transplant Conference 2010. Management Decisions in Renal Transplantation.
6th International Congress of Pathophysiology. 2010. Montreal, Canada. Cardiotonic steroids, hypertension and progressive renal injury.
International Conference on Aging. 2010. Pisa, Italy. Aging and the Kidney: Implications for Cardiovascular Disease.
National Institutes of Health. 2010. Bethesda, MD. Update on the CORAL study.
Cleveland Clinic Foundation: Cell Biology Grand Rounds. 2010. Cardiotonic steroids, natriuresis and hypertension. An update on 3rd factor.
University of Colorado. 2010. Professors’ Rounds. Uremic Cardiomyopathy.
Wayne State University: 2010. Cardiotonic steroids, natriuresis and hypertension. An update on 3rd factor.
International Society of Nephrology Meeting, Vancouver, Canada. 2011. Cardiotonic steroids, renal fibrosis and hypertension.
Baxter International. Westlake, CA. 2011. Pegylated Albumin for systemic capillary leak.
Youbo Pharmaceuticals, Beijing, China. 2011. Pegylated Albumin for systemic capillary leak.
Youbo Pharmaceuticals, Beijing, China. 2011. Sodium pump signaling; a new platform for pharmaceutical development.
American Society for Biochemistry and Molecular Biology. Pacific Grove, CA, 2011. Cardiotonic steroids, Na/K-ATPase signaling and renal fibrosis.
American Society of Nephrology Meeting, Phila, PA. 2011. Cardiotonic steroids, renal fibrosis and hypertension.
American Society of Nephrology Meeting, Phila, PA. 2011. Renal Artery Stenosis (moderator).
Baxter Healthcare, Deerfield, Il. 2012. Pegylated albumin for systemic capillary leak.
University of Toledo Medicine Grand Rounds. Toledo, OH. 2012. Salt and Cardiovascular Disease: Do Cardiotonic Steroids Provide the Molecular Link?
Friendship Hospital. Beijing, China. 2012. Salt and Cardiovascular Disease: Do Cardiotonic Steroids Provide the Molecular Link?
Beijing University Hospital. Beijing, China. 2012. Salt and Cardiovascular Disease: Do Cardiotonic Steroids Provide the Molecular Link?
Zhejiang Academy of Medical Sciences. Hangzhou, China. 2012. Salt and Cardiovascular Disease: Do Cardiotonic Steroids Provide the Molecular Link?
American Society of Hypertension. New York, New York. 2012. Cardiac steroids and cardiac remodeling.
Cabell County Medical Society. Huntington, WV. 2012. New directions for the Marshall University College of Medicine.
Norval Carter Medical Society. Huntington, WV. 2012. Do cardiotonic steroids provide the molecular link between salt and CV disease?
West Virginia ACP Meeting. Stonewall Resort, WV. 2012. Water and Women: Management issues in hyponatremia specific to females.
Huntington City Club. Huntington, WV. 2012. Update on the Joan C Edwards School of Medicine.
Marshall University. Huntington, WV. 2012. Medicine Grand Rounds. Salt, cardiotonic steroids and progressive cardiovascular disease.
Marshall University. Huntington, WV. 2013. State of the Medical School Address.
Marshall University. Huntington, WV, 2013. Research in Progress. CTS, salt handling and oxidant signaling.
University of Toledo, Toledo, OH. 2013. Special Clinical Seminar: Water Metabolism and Women.
George Washington University, Washington, DC. 2013. Renal Grand Rounds. Are cardiotonic steroids the molecular link between dietary salt and cardiovascular disease?
International Conference on CEACAM. 2013. Toledo, OH. CEACAM, Salt and Hypertension.
Marshall Conference on Childhood Obesity. 2013. Huntington, WV. Link between dietary salt, obesity and hypertension.
University of London. 2013. Renal Grand Rounds. Are cardiotonic steroids the molecular link between dietary salt and cardiovascular disease?
University of Colorado. 2014. Laurence Chan Endowed Lectureship. Are cardiotonic steroids the molecular link between dietary salt and cardiovascular disease?
University of Toledo. 2014. Medical Grand Rounds. Are cardiotonic steroids the molecular link between dietary salt and cardiovascular disease?
Marshall University, Huntington WV, 2014. Medicine Grand Rounds. Obesity and Hypertension.
University of Medicine and Dentistry of New Jersey. The 47th Annual Harold J. Jeghers Memorial Lecture. 2015. Signaling through the Na/K-ATPase. Relevance to Salt Handling, CV Disease and Metabolic Syndrome.
Cornell University School of Medicine: New York Presbyterian Hospital. 2015. Signaling through the Na/K-ATPase: Relevance to Salt Handling, CV Disease and Metabolic Syndrome.
Marshall University, Huntington WV. Medicine Grand Rounds. 2016. Water Metabolism in Women.
George Washington University School of Medicine. Renal Grand Rounds. 2015. Signaling through the Na/K-ATPase: Relevance to Salt Handling, CV Disease and Metabolic Syndrome.
Marshall University, Huntington WV. 2016. Medicine Grand Rounds. Obesity, Sodium and CV disease.
New York Medical College, Westchester NY. 2016. Medicine Grand Rounds. Women and Water: Disorders of Water Metabolism Unique to Women.
New York Medical College, Westchester NY. 2016 Cardiology Grand Rounds. Obesity, Sodium and CV Disease.
New York Medical College, Westchester NY. 2016 Pharmacology Grand Rounds. Na/K-ATPase Signaling: Relevance to Renal and Cardiac Disease.
University of Padua, Padua Italy. 2017. Salt, Obesity and Cardiovascular Disease.
University of Catania, Catania Italy. 2017. Cardiotonic Steroids, Sodium Pump Signaling and Cardiovascular Disease.
University of Toledo. Toledo, Ohio. 2017. Renal Grand Rounds. Water metabolism in Women.
3rd Annual Symposium on Urinomics. 2017. Caparica, Portugal. Plenary Lecture. Uremic cardiomyopathy: new concepts in pathogenesis.
Marshall University. Huntington, WV. 2018. Medical Grand Rounds. Obesity, aging and CV disease.
West Virginia University. Morgantown, WV. 2018. Invited Lecture. Obesity aging and CV disease.
Norval Carter Medical Society. Huntington, WV. NaK-ATPase signaling, aging and cardiovascular disease.
West Virginia University. Morgantown, WV. 2018. Invited Lecture. Water and women: special considerations in the evaluation of disorders of water metabolism.
University of Toledo. Toledo Ohio. 2018 Medicine Grand Rounds. Obesity aging and CV disease.
Hong Kong University 2018 Nephrology Grand Rounds Adipocyte Na/K-ATPase oxidant amplification loop and uremic cardiomyopathy.
Norval Carter Medical Society. Huntington, WV. Inflammation and CV disease in CKD. Co-presented with Dr. Rahul Kakkar.
Past and Current Research Trainees:
| |Project |Current Position |
|Trainee (years) | | |
|Yeong Hau (Howard) Lien, M.D., Ph.D. (1986-1989) |Brain Organic Osmoles During Hypo and |Chief, Division of Nephrology and Professor, |
| |Hypernatremia |U of Arizona |
|Deepak Malhotra, M.D., Ph.D. (1987-1990) |Pathophysiology of Cardiac Dysfunction during |Director, Transplant Nephrology, Chief, |
| |Metabolic Acidosis and Pathogenesis of |Division of Nephrology and Professor of |
| |Cyclosporine Nephrotoxicity |Medicine, Medical College of Ohio |
|Robert Hutchison, Ph.D. (1988-1990) |Use of NMR Spectroscopy to Monitor Cytosolic Na |Scientific Writer, Privately Employed |
| |Concentration | |
|Eric Peterson, M.D. |Effect of Hypokalemia on Cardiac Energy |Private Practice of Nephrology |
|(1991-1994) |Metabolism and Function | |
|Howard Weinberger, M.D. (1991-1994) |NMR studies of CK Knockout Mice Hearts During |Professor of Medicine, Univ. of Colorado |
| |Stress | |
|Haoran Jin, Ph.D. |Development of a 3 Dimensional Gradient Surface |Research Professor, Univ of California at San|
|(1991-1994) |Coil for NMR Imaging |Diego |
|Anita Corn, Ph.D. |Development of NMR Surface Coil Imaging |Assistant Professor, University of Colorado |
|(1991-1996) |Techniques |at Denver |
| | | |
|Thomas Rehring, M.D. |Effects of Pharmacological Preconditioning on |Vascular Surgeon, Private Practice |
|(1994-1995) |Cardiac pH Homeostasis During Ischemia | |
|Michael Blei, M.D. |Muscle Energetics and Rehabilitation Potential |Professor of Rehabilitation, Univ. of |
|(1994-1998) | |Colorado |
|Carolyn Yucha, Ph.D., R.N. |Assessment of Sympathetic Nervous System Activity|Dean UNLV School of Nursing |
| |in Hypertension | |
|Sunita Dheenan, M.D. |Autonomic dysfunction in the pathogenesis of |Private Practice of Nephrology |
|(1998-1999) |dialysis hypotension | |
|Jiang Liu, Ph.D. |Effect of Hypokalemia on Cardiac Hypertrophy |Assistant Professor of Medicine, UT |
|(1998-2001) | | |
| | | |
|Jie Chen, B.S. |Effect of Sodium Pump Inhibition on Contractile |Master Degree 2000 |
|(1999-2000) |Function and Cardiac Growth Responses | |
|Afaque Ahktar, M.D. |Assessment of Volume Shifts During Hemodialysis |Private Practice of Internal Medicine |
|(1998-1999) |by Continuous Monitoring of Hematocrit Value | |
|Zyed Gilani, M.D. |Pathobiology of LVH in Hemodialysis Patients |Private Practice of Internal Medicine |
|(1998-1999) | | |
| | | |
|Siva Karunakaran, M.D. (1999-2001) |Assessment of Volume Shifts During Hemodialysis |Private Practice of Nephrology |
| |by Continuous Monitoring of Hematocrit Value | |
|Eiad Omran, M.D. |Effect of renal mass reduction on cardiac calcium|Private Practice of Internal Medicine |
|2000-2001 |cycling and contractile function. | |
| | | |
| |Strain differences in hemodynamic responses to |Private Practice of Nephrology |
|Anand Ravindran, M.D. |reductions in renal mass. | |
|2000-2002 | | |
| | | |
|Anumeet Priyadarshi, M.D. |Effect of renal mass reduction on oxygen tensions|Private Practice of Nephrology |
|2000-2001 |and erythrocyte regulation. | |
|Snigda Priyadarshi, M.D. |Effect of sodium pump inhibition on cardiac |Private Practice |
|2000-2002 |function and metabolism. | |
|David Kennedy |Effect of cardiac steroids on SERCA regulation |University of Toledo Associate Professor |
|2001-2006 (Ph.D.2005). |and function. | |
|Jalla Nadoor, M.D. |Identification and characterization of an |Private Practice of Internal Medicine |
|2001-2002 |inhibitor of the Na pump from PD fluid | |
|Mustafa Aziz, M.D. |Development of a hemodialysis procedure for |Research Assistant |
|2001-2003 |conscious rats | |
| |Mechanisms of NaK-ATPase endocytosis in proximal | |
|Alaa Nadoor, M.D. |tubule cells |Private Practice of Vascular Medicine |
|2002-2003 |Regulation of NaK-ATPase in proximal tubule cells| |
| |by endogenous cardiac glycosides |Private Practice of Internal Medicine |
|Besher Kabak, M.D. | | |
|2002-2003 | | |
|Shadi Oweis, M.D. |Effect of DLS on apical ion transport in proximal|Ph.D. awarded 2010. Private Practice of |
|2002-2009 |tubule cells |Nephrology 2010. |
| |Effect of aldosterone on signal transduction | |
|Adnan Alsaka, M.D. |through the |Private Practice of Nephrology |
|2003-2004 | | |
| |Na/K-ATPase |Private Practice of Internal Medicine |
|Riad Kesiry, M.D. |Proteomic studies of endosomal proteins important| |
|2003-2004 |in Na/K-ATPase endocytosis | |
|Master Degree 2004 | | |
|Mounir Khaled, M.D. |Effect of aerobic conditioning on DLS stimulated |Private Practice of Internal Medicine |
|2003-2004 |downregulation of Na/K-ATPase activity in | |
| |proximal tubule cells | |
| |Role of signal transduction through the | |
| |Na/K-ATPase on diastolic dysfunction in uremic |Faculty in Nephrology, Oregon Health Sciences|
|Sandeep Vetteth, M.D. |cardiomyopathy |University. |
|2003-2005, 2005-2011 |Role of cardiac steroids in the cardiac fibrosis | |
| |seen with experimental renal failure |Private Practice of Internal Medicine |
| | | |
|Yashaswi Belvadi, M.D. | | |
|2004-2005 | | |
|Michael Garrett |Genetic mechanisms operant in proteinuria in the |Associate Professor of Medicine (University |
|2004-2006 |Dahl rat |of Mississippi) |
| | | |
|Jihad El-Kareh |Role of cardiotonic steroids in the pathogenesis |Pharmaceutical Company Scientist |
|2004-2008 |of cardiac fibrosis in experimental renal failure| |
|Shalini Gupta |Cross talk between ceacam-1 and sodium pump |MD/PhD 2014 |
|2005-2012 |signaling | |
| | | |
| | | |
|Sleiman Smali |Role of cardiotonic steroids in would healing |Ob/Gyn Physician 2010 |
|2005-2006 | | |
|Nasser El-Okdi |Role of cardiotonic steroids in would healing |M.D. 2012 |
|2006-2008 | |IM Physician |
| |Role of platelet derived proteins in progressive | |
|Steve Haller |renal injury |Ph.D. 2012 |
|2008-2012 | |Assistant Professor |
| |Role of cardiotonic steroids in cardiac fibrosis | |
| | | |
|Georgy Budnyy, MD |Role of endocytosis in sodium pump signaling |Assistant Professor |
|2008-2011 | | |
| |Effect of CTS on epigenetic changes in cellular | |
|Yanling Yan |phenotype. |Ph.D. 2012 |
|2009-2012 | |Assistant Professor |
| |Effect of Na/K-ATPase signaling on uremic | |
|Christopher Drummond, PhD |cardiomyopathy |Industry position |
|2011-12 | | |
| | | |
| |Role of adipocyte in uremic cardiomyopathy | |
|Kyle Maxwell | |Medical Student |
|2013-15 | | |
| | | |
| | | |
| | | |
|Rebecca Martin | |Ph.D. Student |
|2015-present | | |
Institutional Clinical Activities:
University of Colorado
1986-1991 Director, Chronic Hemodialysis Service
Developed treatment protocols and policies for care of chronic hemodialysis patients. Oversaw care of approximately 100 chronic hemodialysis patients.
1988-1995 Co-Director, Renal Transplant Physicians
Developed treatment protocols and policies for care of renal transplant and combined renal/pancreas transplant patients. Involved in care of nearly 400 renal or renal/pancreas transplant patients during this time. Participated in the reestablishment and community marketing of the University Transplant program which had essentially shut down between 1987-88.
1995-1997 Director, Denver VA Transplant Clinic
Developed treatment protocols and policies for care of renal transplant and renal/pancreas transplant patients at the Denver VAMC.
1996-1997 Renal Section Chief, Denver VA Medical Center
Oversaw educational and clinical care activities for patients with renal diseases at the Denver VAMC. Developed plan for maintaining in center hemodialysis unit during period of proposed downsizing (1995-97).
University of Toledo
1997-1999 Renal Division Chief
Oversaw educational and clinical care activities for patients with renal diseases at the Medical College of Ohio Hospitals. Established minority ownership for Department of Medicine and the associated physicians of the Medical College of Ohio (APMCO) in the newly formed Dialysis Partners free standing hemodialysis units (formerly Greenfield Dialysis Facilities of Toledo).
1999-1999 Acting Chairman, Department of Medicine
1999-pres Chairman, Department of Medicine
Oversee all research, clinical and administrative aspects for the Department of Medicine
2006. Interim Chairman, Department of Physiology
Oversee research and administrative aspects of Department of Physiology. Term ended with merger of Physiology and Pharmacology.
2006-2012 Associate Dean for Business Development
Oversee mergers/acquisitions/research partnerships for UT College of Medicine.
Institutional Committee Work:
University of Colorado
1992-1997 Faculty Development Committee
Participated in the development and implementation of mentoring guidelines to structure junior faculty career planning within the Department of Medicine.
1988-1997 Renal Transplant Service Committee
Participated in the group which developed and implemented recipient and donor selection as well as protocol evaluation for renal and renal/pancreas transplantation.
1987-1997 Renal Division Fellowship Committee
Participated in the recruitment and education of Nephrology fellows. Participated in the development and implementation of a Nephrology fellowship educational curriculum.
1988-1995 University Hospital End Stage Renal Disease CQI Committee (Chairman, 1992-95). Developed parameters to monitor and evaluate as indicators of the quality of ESRD treatment delivered at University Hospital. Chaired committee during JCAHO evaluation.
1996-1997 Renal Division Executive Committee
Participated as the VA representative to a three member committee overseeing the clinical and research activities of the University of Colorado Renal Division.
University of Toledo
1997- 2000. Faculty Development Committee.
Participate in the planning and implementation of “Teach the Teachers”.
1997- 2012. Medicine Residency Review Committee
Participate in the recruitment, curriculum development and implementation of the MCO Medical Residents and Subspecialty Fellows.
1998- 2000. Institutional Animal Care and Utilization Committee
Participate in the evaluation of research or teaching protocols utilizing animals.
1999- 2001. Associate Physicians of Medical College of Ohio Executive Committee.
Elected to 9 member committee to oversee reform of APMCO.
1999- 2004. Associate Physicians of Medical College of Ohio Finance Sub-committee.
Participate in the financial management of APMCO.
1998- 2004 Clinical Resource Utilization Committee.
Participate in this recently formed organization developed to assess and improve utilization of clinical resources at MCO.
1999- 2004 Curriculum Committee.
Development and maintenance of MCO medical school curriculum
1999- 2001. Internal Referral Committee
Development of approaches to obstacles for internal referral
1999- 2005. Clinical Strategic Planning Committee
Oversee MCO's overall clinical strategic plan.
2000- 2006 MCO Cancer Research Center Advisory Board
2000-2009 Medical Student Research Committee.
Evaluate summer fellowship applications.
2001-2004 MCO Strategic Planning Committee.
Participate in the formulation of strategic plan for the institution.
2001-2003 MCO Cardiovascular task force (Chairman).
Develop a business plan for developing an cardiovascular institute.
2001-2005 Mini-med school planning committee (Chairman and course director). Develop and implement a mini-med school course.
2001-2012 MCO Bioinformatics Steering Committee.
Participate in the direction of the MCO bioinformatics initiative.
2001-2006 MCO Bioinformatics Oversight Committee (Chairman).
Develop goals, objectives and metrics for evaluating the bioinformatics program.
2001-2002 Value Analysis Committee.
Evaluate hospital business decisions.
2002-2003 Patient Volume Committee.
Evaluate obstacles to increasing patient volumes at MCOH.
2002-2006 Honorary Degree Committee.
Select honorary degree recipients.
2002-2003 MCO President Search Committee.
Search for a new President of the Medical College of Ohio.
2003-2005 APMCO restructuring task force.
Develop guidelines for restructuring of the physicians’ practice plan.
2003-2006 MCO President’s Cabinet.
Assist the President on making decisions regarding strategic planning.
2003-2008 Distinguished Lecturers Committee.
Select outside speakers for selected lectures.
2003-2004 Chairman, Ob/Gyn Chair Search Committee.
Identified Dr. Terrence Horrigan as chair of Ob/Gyn for MCO.
2003-2005 Chairman, Institutional Resources Self Study (LCME).
Develop a report for LCME visit regarding institutional resources.
2003-2004 Pathology Chair Search Committee.
Search for a new Pathology chair.
2004-2004 Dean Search Advisory Committee.
Develop guidelines for MCO School of Medicine Dean Search.
2005-2008 Research Advisory Council.
Advise Dean on research matters.
2005-2012 Clinical Advisory Council (Chairman).
Advise Dean on clinical matters.
2005-2007 Task Force for Improving MCOP (physician professional organization).
2006-2012 UT Finance and Strategic Planning Committee.
Develop financial plan and form strategy for merged UT/MUO
2006-2012 Provost advisory council.
Advise provost on strategic planning and operations.
2006-2012 UT Strategic Planning Council.
Advise president on strategic planning.
2006-2012 UT College of Medicine Leadership Committee.
Advise Dean on academic matters.
2006-2011 UT Physicians Executive Committee.
Represent Dean’s office at UTP executive committee.
2007 Pathology Search Committee (Chairman)
Identified Dr. Robert Mrak as chair for UT Pathology
2007-2012 Strategic Planning Committee for COM addressing research.
2007-2012 Strategic Planning Committee for COM addressing clinical enterprise.
2007-2012 Strategic Planning Committee for COM addressing economic development (Chairman).
2007-2012 University of Toledo Physicians managed care committee. Develop and negotiate contracts with 3rd party payers (Chairman).
2008-2009 Physiology/Pharmacology Chairman Search Committee
2011-2011 Chair of Public Health Search Committee
Selected Dr. Sheryl Miltz.
2011-2011 CMIO Search Committee
Selected Dr. Carl Sirio.
2011-2012 UTP Executive Committee, Chairman
Oversee executive committee of UTP
2011-2012 University of Toledo External Affairs Committee
Advise UT Board of Trustees on external affairs of University
Marshall University
2012-present MU Senior Leadership
Oversee direction of Marshall University
2012-present UP&S Board of Directors (Chairman)
Oversee direction of physician practice plan
2012-present JCESOM LCME Preparation Committee
Prepare for LCME visit as well as review accreditation standards
2012-present GME Committee
Oversee graduate medical education
2012-present JCESOM Executive Committee
Oversee functions of medical school
2012-present JCE Cancer Center Board of Directors
Oversee functions of cancer center
2012-present JCESOM Strategic Planning (Chairman)
Develop and implement strategic planning
2013-present Marshall University Research Corporation
Oversee research at Marshall University
2017-present Clinical Integration Network (board member)
Create CIN to provide care to Medicare recipients
Bibliography:
Published Original Research Articles:
1. Shapiro, J.I., W. Argy, T. Rakowski, A. Chester, A. Siemens, and G.E. Schreiner. 1983. The unsuitability of BUN as a criterion for prescription dialysis. Trans. Am. Soc. Art. Intern. Org. 29:129-132.
2. Shapiro, J.I., C. Cheung, A. Itabashi, L. Chan, and R.W. Schrier. 1985. The protective effect of verapamil on renal function after warm and cold ischemia in the isolated perfused rat kidney. Transplant. 40:596-600.
3. Mills, S., U. Schwertschlag, J.I. Shapiro, L. Chan, and R.W. Schrier. 1986. Emopamil protects against warm and cold ischemia in the isolated rat kidney. Transplant. 43:928-930.
4. Shapiro, J.I., and L. Chan. 1987. P-31 nuclear magnetic resonance study of urinary obstruction in the rat. J. Clin. Invest. 80:1422-1427.
5. Shapiro, J.I., and L. Chan. 1987. In vivo determination of absolute molar concentrations of renal phosphorus metabolites using the proton concentration as an internal standard. J. Mag. Reson. 75:125-128.
6. Haug, C.E., J.I. Shapiro, L. Chan, and R. Weil,III. 1987. Atrial natriuretic peptide levels are elevated in rats bearing rejected heart-lung allografts. Biomed. Biophys. Res. Comm. 146:625-629.
7. Shapiro, J.I., C.E. Haug, R. Weil,III, and L. Chan. 1987. P-31 nuclear magnetic resonance study of acute renal dysfunction in rat kidney transplants. Mag. Res. Med. 5:346-352.
8. Nakamoto, M., J.I. Shapiro, L. Chan, and R.W. Schrier. 1987. The invitro and invivo protective effect of atriopeptin III in ischemic acute renal failure in the rat. J. Clin. Invest. 80:698-705.
9. Haug, C.E., J.I. Shapiro, L. Chan, and R. Weil,III. 1987. P-31 NMR study of heterotopic cardiac allograft rejection in the rat. Transplant. 44:175-178.
10. Haug, C.E., J.I. Shapiro, L. Chan, and R. Weil,III. 1987. Groin kidney transplantation as a model for NMR study. Surgery 103:305-310.
11. Shapiro, J.I., A. Itabashi, C. Cheung, N. Rossi, R.W. Schrier, and L. Chan. 1987. The effect of ATP depletion on renal function with and without ischemia in the isolated rat kidney. Min. Elect. Metab. 13:415-421.
12. Itabashi, A., J.I. Shapiro, C. Cheung, L. Chan, and R.W. Schrier. 1987. Proximal action of atriopeptin III in the isolated perfused kidney. Clin. Sci. 73:143-150.
13. Veis, J., R. Contiguglia, M. Klein, J. Mishell, A.C. Alfrey, and J.I. Shapiro. 1987. Mucormycosis in dialysis patients receiving desferroxamine. Ann. Intern. Med. 107:258-259.
14. Shapiro, J.I., C.E. Haug, R. Weil,III, and L. Chan. 1988. P-31 NMR study of renal allograft rejection in the rat. Transplant. 45:17-21.
15. Shanley, P.F., J.I. Shapiro, L. Chan, T.J. Burke, and G.C. Johnson. 1988. Acidosis and hypoxic medullary injury in the isolated perfused kidney. Kidney Int. 34:791-796.
16. Haug, C.E., J.I. Shapiro, R.L. Cosby, L. Chan, and R. Weil,III. 1988. P-31 nuclear magnetic resonance spectroscopy of heart, heart-lung and kidney allograft rejection in the rat. Transpl. Proc. 20:848-855.
17. Nakamoto, M., J.I. Shapiro, S. Mills, R.W. Schrier, and L. Chan. 1988. Verapamil improves renal preservation by 24 hour cold perfusion in the isolated rat kidney. Transplant. 45:313-315.
18. Shapiro, J.I., S. Mills, R.W. Schrier, and L. Chan. 1989. Effects of ATP depletion in vivo on renal function with and without ischemia. Min. Elect. Metab. 13:415-421.
19. Shapiro, J.I., M. Whalen, R. Kucera, N. Kindig, G. Filley, and L. Chan. 1989. Brain pH responses to sodium bicarbonate and Carbicarb during systemic acidosis. Am. J. Physiol. 256:H1316-H1321.
20. Shapiro, J.I., R.L. Cosby, and L. Chan. 1989. P-31 nuclear magnetic resonance spectral changes in obstructed or dehydrated kidney. Kidney Int. 35:830-835.
21. Molitoris, B.A., L. Chan, J.I. Shapiro, J.D. Conger, and S.A. Falk. 1989. Loss of epithelial polarity: a novel hypothesis for reduced proximal tubule Na+ transport following ischemic injury. J. Membrane Biol. 107:119-127.
22. Kindig, N.B., D. Sherril, J.I. Shapiro, and G.F. Filley. 1989 Extracorporeal bicarbonate space following bicarbonate or bicarbonate/carbonate mixture in acidotic dogs. J. Appl. Physiol. 67:2331-2334.
23. Kucera, R.R., J.I. Shapiro, M.A. Whalen, N.B. Kindig, G.F. Filley, and L. Chan. 1989. Brain pH effects of NaHCO3 and Carbicarb in lactic acidosis. Crit.Care Med. 17:1320-1323.
24. Yuan, B., M. Klein, S.R. Contiguglia, J. Mishell, N. Miller, B. Molitoris, A.C. Alfrey, and J.I. Shapiro. 1989. The role of aluminum in the pathogenesis of anemia in an outpatient hemodialysis population. Renal Failure 10:112-114.
25. Shapiro, J.I., D.C.H. Harris, R.W. Schrier, and L. Chan. 1990. Attenuation of hypermetabolism in the remnant kidney by dietary phosphate restriction in the rat. Am. J. Physiol. 258:F183-188.
26. Howard, R., J.I. Shapiro, S. Babcock and L. Chan: 1990. Effect of calcium channel blockers on cyclosporine dose requirements in renal transplant recipients. Renal Failure. 12:89-92.
27. Austin, J., M. Klein, M. Levy, S.R. Contiguglia, J. Mishell, and J.I. Shapiro. 1990. Intraocular pressures during high flux hemodialysis. Renal Failure. 12:109-112.
28. Shapiro, J.I., A. Mathew, M.A. Whalen, B. Honigman, W.D. Kaehny, T.L. Petty, and L. Chan: 1990. Different effects of bicarbonate and Carbicarb in normal volunteers. J. Crit. Care. 5:1-4.
29. Lien Y.H., J.I. Shapiro and L. Chan: 1990. Regulation of brain organic osmoles during hypernatremia. J. Clin. Invest. 85:1427-1435.
30. Shapiro, J.I.: 1990. Functional and metabolic responses of the isolated heart to acidosis: Effects of sodium bicarbonate and Carbicarb. Am. J. Physiol. 258:H1835-H1839.
31. Howard, R., L. Chan, K. Tatum and J.I. Shapiro: 1990. Plasmapheresis by nephrologists: A survey. Dial. Transplant. 19:484-485.
32. Hutchison, R.B., D.K. Malhotra, R.E. Hendrick, L. Chan and J.I. Shapiro: 1990. Evaluation of the double quantum filter for the measurement of intracellular sodium concentration. J. Biol. Chem. 265:15506-15510.
33. Zhou, H.Z., J.I. Shapiro, L. Chan and R.W. Schrier: 1990. Atrial natriuretic peptide (ANP) protects against cold ischemia in the isolated and in situ rat kidney. J.A.S.N. 1:927-928.
34. Whalen, M.A. and J.I. Shapiro: 1991. Hemodynamic and hepatic pH responses during different forms of ventilation. Mag. Reson.Imaging. 9:229-234.
35. Chan, L., G. Suleymanlar, D.K. Malhotra, Y.H. Lien, and J.I. Shapiro: 1991. NMR and biochemical findings of synergistic interaction of ischemic injury and cyclosporine nephrotoxicity in the rat. Transplant. Proc. 23:711-713.
36. Kucera, R., M. Whalen, and J.I. Shapiro: 1991. EEG responses to bicarbonate and Carbicarb during lactic acidosis in the rat. J. Crit. Illness 6:71-74.
37. Lien, Y.H., J.I. Shapiro, and L. Chan: 1991. Organic brain osmolytes during induction and therapy of hyponatremia. J. Clin. Invest. 88:303-309.
38. Jarusirripipat, C., H.Z. Zhou, J.I. Shapiro, L. Chan and R.W. Schrier: 1991. Low protein diet ameliorates renal hypermetabolism in the remnant kidney. Am. J. Kid. Dis. 18:367-374.
39. Malhotra, D., H.Z. Zhou, J.I. Shapiro and L. Chan: 1991. Improved experimental cardiac preservation based on metabolic manipulations. Transplant. 52:1004-1008.
40. Rees, B.B., D. Malhotra, J.I. Shapiro, and S.C. Hand: 1991. Intracellular pH changes during estivation in the land snail Oreohelix stigosa. J. Exp. Biol. 159:525-530.
41. Malhotra, D., J.I. Shapiro and L. Chan. 1991. Utility of H-1 NMR spectroscopy in the differential diagnosis of anion gap acidosis. J.A.S.N. 2:1046-1050.
42. Zhou, H.Z., D. Malhotra and J.I. Shapiro: 1991. Contractile failure during metabolic acidosis: role of impaired energy metabolism. Am. J. Physiol. 261:H1481-H1486.
43. Jarusiripipat, C., H.Z. Zhou, J.I. Shapiro, L. Chan, and R.W. Schrier. 1992. Effect of long-acting calcium entry blocker on blood pressure, renal function and survival of uremic rats. J. Pharm. Exp. Therap. 260:243-247.
44. Hiatt, W.R., B.J. Koziol, J.I. Shapiro, and E.P. Brass: 1992. Carnitine metabolism during exercise in patients on chronic hemodialysis. Kidney Int. 41:1613-1619.
45. Suleymanlar, G., H.Z. Zhou, M. McCormack, N. Elkins, R. Kucera, O.K. Reiss and J.I. Shapiro. 1992. Mechanisms of impaired energy metabolism during acidosis role of oxidative metabolism. Am. J. Physiol. 263:H1818-H1822.
46. Hutchison, R.B., J.J.A. Huntley, H. Jin and J.I. Shapiro. 1992. Suppression of sodium NMR double-quantum coherence by chemical shift and relaxation reagents. J. Chem. Physics. 97:8934-8940.
47. Zhou, H.Z., D. Malhotra, J. Doers and J.I. Shapiro. 1993. Hypoxia and metabolic acidosis in the isolated heart: evidence for synergistic injury. Mag. Reson. Med. 29:94-98.
48. Hutchison, R.B., J.J.A. Huntley, H.Z. Zhou, D.J. Ciesla and J.I. Shapiro. 1993. Alteration in sodium binding sites with prolonged ischemia in the isolated perfused heart. Mag. Reson. Med. 29:391-395.
49. Huntley, J.J.H., M. McCormack, H. Jin, R. B. Hutchison and J.I. Shapiro. 1993. Importance of the tonicity of Carbicarb on the functional and metabolic responses of the acidotic isolated heart. J. Crit. Care. 8:222-227.
50. Chan, L., A. Chittinandana, J.I. Shapiro, and P.F. Shanley and R.W. Schrier. 1994. Effect of an endothelin-receptor antagonist on ischemic acute renal failure. Am. J. Physiol. 266:F135-F138.
51. Suleymanlar, G. , I. Suleymanlar, J.I. Shapiro and L. Chan. 1994. Possible role of lipid peroxidation in cyclosporine nephrotoxicity in rats. Transplant Proceedings. 26:2888-2889.
52. Suleymanlar, G., I. Suleymanlar, J.I. Shapiro and L. Chan. 1994. Efficacy of Verapamil in prevention of cyclosporine nephrotoxicity in rats. Transplant Proceedings. 26:2896-2898.
53. Shapiro, J.I., N. Elkins, G. Suleymanlar, O.K. Reiss, H. Jin, R.W. Schrier, and L. Chan. 1994. Energy metabolism in chronic renal failure. Kidney Int. 45:S100-105.
54. Snyder,G.K., J.R. Nestler, J.I. Shapiro, and J. Huntley. 1995. Intracellular pH in lizards after hypercapnia. Am.J.Physiol. 268:R889-R895.
55. Evans, T., H. Jin and J.I. Shapiro. 1995. Effect of acidosis on hydrogen peroxide injury to the isolated perfused rat heart. Am.J. Physiol. 269:H308-312.
56. Shapiro, J.I., N. Elkins, J. Logan, L.B. Ferstenberg and J.E. Repine. 1995. Effects of sodium bicarbonate, disodium carbonate and a sodium bicarbonate/carbonate mixture on the PCO2 of blood in a closed system. J.Clin.Lab.Med. 126:65-69.
57. Kwan, K., J.I. Shapiro B.B. Rees, and S. Hand. 1995. Oxidative phosphorylation and realkalinization of intracellular pH during recovery from anoxia in Artermia franciscana embryos. Biochimica et Biophysica Acta . 1232: 5-12.
58. Peterson, E.W., K.G. Chen, N. Elkins, R.B. Hutchison and J.I. Shapiro. 1995. NMR spectroscopy studies of severe hypokalemia in the isolated rat heart. Am.J. Physiol. 269:H1981-H1987.
59. Banerjee A, F. Gamboni-Robertson, M.B. Mitchell, T.F. Rehring, K. Butler, J. Cleveland, D.R. Meldrum , J.I. Shapiro, and X.Z. Meng .1996. Stress-induced cardioadaptation reveals a code linking hormone receptors and spatial redistribution of PKC isoforms. .Ann N Y Acad Sci. 793:226-39.
60. Rehring, T.F., P.R. Bender, C.B. Cairns, K. Joo, R.S. Friese, J.I. Shapiro, J.C. Cleveland, Jr., and A. Banerjee. 1997. Different preconditioning stimuli invoke disparate electromechanical and energetic responses to global ischemia in rat hearts. Can.J.Physiol.Pharmacol. 75:335-342.
61. Shapiro, J.I. 1997. Pathogenesis of cardiac dysfunction during metabolic acidosis: Therapeutic Implications. Kidney Int. .61: S41-47.
62. Jacob, A.D., N. Elkins, O.K. Reiss, L. Chan and J.I. Shapiro. 1997. Effects of acetate on energy metabolism and function in the isolated perfused rat heart. Kidney Int. 52:755-760.
63. Shapiro, J.I., A. Banerjee, O.K. Reiss and N. Elkins. 1998. Effects of acute and chronic hypokalemia on metabolic and physiological responses to hypoxia. Am. J. Physiol. 274:H1598-1604.
64. Roehring, T., J.I. Shapiro, E.W. Peterson, R. Freis, F. Robertson and A. Banerjee. 1998. Effects of pharmacological preconditioning on cardiac energy metabolism and intracellular pH. Am. J. Physiol. 275:H805-813.
65. Jacob, L.P. , D. Malhotra and J.I. Shapiro. 1999. Clinical dose response effects of various calcium channel blockers on cyclosporine blood levels in renal transplant recipients. AJKD.33:301-303.
66. Cochrane, J., C. Cairns, B. Williams, T.J. Burke, A. Harken, A. Banerjee and J.I. Shapiro. 1999. Ischemic preconditioning provides functional, histological and biochemical protection against ischemic acute renal failure in the rat. Renal Failure. 21:135-45.
67. Xie, Z., P. Kometiani, J. Liu, J.I. Shapiro and A. Askari. 1999. Intracellular reactive oxygen species mediate the linkage of Na+/K+-ATPase to hypertrophy and its marker genes in cardiac myocytes. J. Biol. Chem. 274:19323-8.
68. Shinn, C., D. Malhotra, L. Chan and J.I. Shapiro. 1999. Time course of functional response of rejecting renal allografts to prednisolone therapy. AJKD. 34:304-307:
69. Burke, T.J., D. Malhotra and J.I. Shapiro. 1999. pH gradients along the nephron; a consequence of countercurrent vascular architecture. Kidney Int.56:1826-37.
70. Xie, Z., J. Liu, D. Malhotra, T. Sheridan, S.M. Periyasamy, J.I. Shapiro. 2000. Effects of sodium pump inhibition by hypokalemia on cardiac growth. Renal Failure 22:561-572.
71. Liu, J., M. Haas, J. Tian, J.I. Shapiro, A. Askari and Z. Xie. 2000. Ouabain interaction with cardiac Na/K-ATPase initiates signal cascades independent of changes in intracellular Na+ and Ca+ concentrations. J. Biol. Chem. 275(36):27838-44.
72. Chen, J., G. Feller, J. C. Barbato, S. Periyasamy, L. G. Koch, J. I. Shapiro and S. L. Britton. 2001. Cardiac performance in inbred rat genetic models of low and high aerobic capacity. J. Physiol.535:611-617.
73. Burke, T.J., D. Malhotra and J.I. Shapiro. 2001. Effect of enhanced oxygen release from hemoglobin with RSR13 on acute renal failure in the rat. Kidney Int. 60:1407-1414.
74. Assaly, R.A., D. Olson, J. Hammersley, J. Liu, J.I. Shapiro, and B. Kahaleh. 2001. Endothelial apoptosis in systemic capillary leak syndrome. Chest.120:1301-1308.
75. Tomita, M., S. Dheenan, D. Malhotra, J.I. Shapiro, W.L. Henrich and T. Santoro. 2001. Cytokine activation correlates with dialysis hypotension. Renal Failure, 23(5), 637-649.
76. Periyasamy, S.M., D. Cooney, P. Carter, J. Chen, J. Tian, D. Malhotra, Z. Xie and J.I. Shapiro. 2001. Effect of uremic serum on isolated cardiac myocyte calcium cycling and contractile function. Kidney Int. 60:2367-2376.
77. Priyadarshi, A., S.M. Periysamy, T.J. Burke, S.L. Britton, D. Malhotra, and J.I. Shapiro. 2002. Effects of reduction of renal mass on renal oxygen tension and epo production in the rat. Kidney Int. 61:542-546.
78. Barbato, J.C., P.J. Mulrow, J.I. Shapiro and R. Franco-Saenz. 2002. Rapid effects of aldosterone and spironolactone in the isolated working rat heart. Hypertension. 40:130-5.
79. Liu, J., S.M. Periyasamy, W. Gunning, O.V. Fedorova, A.Y. Bagrov, D. Malhotra, Z Xie, and J.I. Shapiro. 2002. Effects of cardiac glycosides on sodium pump expression and function in LLC-PK1 and MDCK cells. Kidney Int. 62:2118-2125.
80. Kennedy, D., E. Omran, S. M. Periyasamy, J. Nadoor, A. Priyadarshi, J.C. Willey, D. Malhotra, Z. Xie and J.I. Shapiro. 2003. Effect of chronic renal failure on cardiac contractile function, calcium cycling and gene expression of proteins important for calcium homeostasis in the rat. J.A.S.N. 14:90-97.
81. Tian J., J Liu, K.D. Garlid, J.I. Shapiro, and Z. Xie. 2003. Involvement of mitogen-activated protein kinases and reactive oxygen species in the inotropic action of ouabain on cardiac myocytes. A potential role for mitochondrial K(ATP) channels. Mol. Cell. Biochem. 242:181-187.
82. Priydarshi, S., B. Valentine, C. Han, O. V. Fedorova, A. Y. Bagrov, J. Liu, S.M. Periyasamy, D. J. Kennedy, D. Malhotra, Z Xie and J.I. Shapiro. 2003. Effect of green tea extract on cardiac hypertrophy following 5/6th nephrectomy in the rat. Kidney Int. 63:1785-1790.
83. Reddy, B.K., D. J. Kennedy, W. R. Colyer, M. W. Burket, W. J. Thomas, S. A. Khuder, J. I. Shapiro, R. V. Topp and C. J. Cooper. 2003. Compliance with antihypertensive therapy after renal artery stenting. Biol. Res.Nurs. 5:37-46.
84. Kennedy, D.J., W.R. Colyer, P.S. Brewster, M. Ankenbrandt, M.W. Burket, A.S. Nemeth, S.A. Khuder, W.J. Thomas, J.I. Shapiro, C.J. Cooper. 2003. Renal insufficiency as a predictor of adverse events and mortality after renal artery stent placement. Am.J.Kidney.Dis. 42: 926-35.
85. Liu, J., S.M. Periyasamy, D. Malhotra, Z. Xie and J.I. Shapiro. 2004. Ouabain Induces endocytosis of plasmalemmal Na/K-ATPase in llc-pk1 cells by a clathrin dependent mechanism. Kidney Int. 66:227-241.
86. Assaly, R.A., M. Azizi, D. J. Kennedy, C. Amauro, A. Zaher, F.W. Hout, R.H. Habib, J.I. Shapiro and J.D. Dignam. 2004. Plasma expansion by polyethylene glycol modified albumin. Clin. Research. 107: 227-241.
87. Barbato, J.C., S. Rashid, P.J. Mulrow, J.I. Shapiro and R. Franco-Saenz. 2004. Evidence supporting independent mechanisms for aldosterone and spironolactone induced inotropy in the rat heart. Hypertension. 44:751-757.
88. Liu, J., M. Liang, L. Liu, D. Malhotra, Z. Xie, and J.I.Shapiro. 2005. Ouabain induced endocytosis of the plasmalemmal Na/K-ATPase in LLC-PK1 cells requires caveolin-1. Kidney Int. 67: 1844-1854.
89. Periyasamy, S.M., J. Liu, F. Tanta, B. Kabak, B. Wakefield, D. Malhotra, D.J. Kennedy, A. Nadoor, O.V. Fedorova, W. Gunning, Z. Xie, A.Y. Bagrov and J.I. Shapiro. 2005. Salt loading induces redistribution of the plasmalemmal Na/K-ATPase proximal tubule cells. Kidney Int. 67:1858-1877.
90. Kennedy, D.J., M.W. Burket, S.A. Khuder, J.I. Shapiro, R.V. Topp and C.J. Cooper. 2006. Quality of Life Improves After Renal Artery Stenting. Biol Res Nurs. 8:129-137.
91. Kennedy, D.J., S. Vetteth, S.M. Periyasamy, M. Kanj, L. Fedorova, S. Khouri, M. B. Kahaleh, Z. Xie, D. Malhotra, N. Kolodin, E. G. Lakatta, O.V. Fedorova, A.Y. Bagrov and J.I. Shapiro. 2006. Central role for the cardiotonic steroid, marinobufagenin, in the pathogenesis of experimental uremic cardiomyopathy. Hypertension. 47:488-495.
92. Oweis, S. L. Wu, H. Zhao, P.R. Kiela, D. Malhotra, F.K. Ghishan, Z. Xie, J.I. Shapiro and J. Liu. 2006. Cardiac glycosides downregulate apical NHE3 expression in LLC-PK1 cells. Am. J. Physiol.- Renal Physiol. 290:F997-1008.
93. Henrich, W.L., R.L. Clark, J.P. Kelly, V.M. Buckalew, A. Fenves, W.F. Finn, J.I. Shapiro, P.L. Kimmel, P. Eggers, L.E.Agodoa, G.A. Porter, S. Shapiro, R. Toto, T. Anderson, L. Adrienne-Cupples and D.W. Kaufman. 2006. Non-contrast enhanced computerized tomography and analgesic related kidney disease: report of the national analgesic nephropathy study. J.A.S.N. 17:1472-80.
94. Kennedy, D.J., S. Vetteth, M. Xie, S.M. Periyasamy, Z. Xie, C. Han, V. Basrur, V. Federov, K. Mutgi, D. Malhotra and J.I. Shapiro. 2006. Ouabain decreases sarcoplasmic calcium ATPase (SERCA2a) activity in rat hearts by a process involving protein oxidation. Am.J.Physiol.-Heart. 291:H3003-11.
95. Kennedy, D.J., M. Xie, S. Vetteth, D. Malhotra and J.I. Shapiro. 2006. Hypokalemia potentiates ouabain’s effect on calcium cycling and cardiac growth. Cell.Mol.Biol. 52(8):87-91.
96. Elkareh, J., D.J. Kennedy, B. Yashaswi, S. Vetteth, A. Shidyak, E.G.R. Kim, S. Smaili, S.M. Periyasamy, I.M. Hariri, L. Fedorova, J. Liu, L. Wu, M.B. Kahaleh, Z. Xie, D. Malhotra, O.V. Fedorova, V.A. Kashkin, A.Y. Bagrov and J.I. Shapiro. 2007. Marinobufagenin stimulates fibroblast collagen production and causes fibrosis in experimental uremic cardiomyopathy. Hypertension. 49:215-224.
97. Liang, M., J.Tian, S. Pierre, J. Liu, J. Shapiro and Z. Xie. 2007.Identification of a pool of non-pumping Na/K-ATPase. J. Biol. Chem. 282:10585-93.
98. Assaly, R.A., M. Azizi, R. Habib, J.I. Shapiro and J.D. Dignam. 2008. Use of multiple fluorophores for evaluating microvascular permeability in control and septic rats. Clinical Science114:123-30..
99. Kennedy, D.K., J. Elkareh, A. Shidyak, A.P. Shapiro, S. Smaili, K. Mutgi, S. Gupta, J. Tian, E. Morgan, S. Khouri, C.J. Cooper, S.M. Periyasamy, Z. Xie, D. Malhotra, O. V. Fedorova, A.Y. Bagrov and J.I. Shapiro. 2008. Partial nephrectomy as a model for uremic cardiomyopathy in the mouse. Am. J. Physiol. Renal Physiol. 294:F450-4.
100. Cai, H. L. Wu, W. Qu, D. Malhotra, Z. Xie, J.I. Shapiro and J. Liu. 2008. Regulation of apical NHE3 trafficking by ouabain-induced activation of basolateral Na/K-ATPase receptor complex. Am. J. Physiol.Cell.Physiol. 294:C555-63.
101. Cooper CJ, Haller ST , Colyer W, Steffes M, Burket MW, Thomas WJ, Safian R, Reddy B, Brewster P, Ankenbrandt MA, Virmani R, Dippel E, Rocha-Singh K, Murphy TP, Kennedy DJ, Shapiro JI, D’Agostino RD, Pencina MJ, Khuder S. 2008. Embolic Protection and Platelet Inhibition During Renal Artery Stenting. Circulation. 117:2752-2760. PMID: 18490527.
102. El-Okdi, N, S Smaili, V Raju, A Shidyak, S Gupta, L Fedorova, J Elkareh, S Peryasamy, AP Shapiro, MB Kahaleh, D Malhora, Z Xie and JI Shapiro 2008 J. Appl. Physiol. 105: 30-36.
103. Kleshinkski J, S.A. Khuder, J.I. Shapiro and J. Gold. 2009. Impact of preadmission variables on USMLE step 1 and step 2 performance. Adv. In Health Sci. Education.14: 69-78.
104. Fedorova, L, V Raju, N El-Okdi, A Shidyak, S Vetteth, D Kennedy, S Vetteth, D Giovannucci, AY Bagrov, O Fedorova, JI Shapiro and D Malhotra. 2009. Cardiotonic steroid hormone marinobufagenin induces renal fibrosis: Implications of epithelial to mesenchymal transition. Am.J.Physiol. 296:F922-34.
105. Packard, M, Y Saad, W. Gunning, S. Gupta and J Shapiro and M Garrett. 2009. Investigating the effect of genetic background on proteinuria and renal injury using two hypertensive strains. Am.J.Physiol. 296:F839-46
106. Kanjwal, K, S Haller M Steffes, R Virmani, JI Shapiro, MW Burket, CJ Cooper and WR Colyer. 2009. Complete versus partial distal embolic protection during renal artery stenting. Catheter Cardiovasc. Interv. 73:725-30.
107. Elkareh, J, SM Periyasamy, A Shidyak, S Vetteth, J Schroeder, V Raju, I Hariri, N El-Okdi, S Gupta, L Fedorova, J Liu, O Fedorova, M Kahaleh, Z Xie, D Malhotra, D Watson, A Bagrov and JI Shapiro. 2009. Marinobufagenin Induces Increases in Procollagen Expression in a Process Involving Protein Kinase C and Fli-1. Am. J. Physiol. 296:F1219-26.
108. Kasmani, R, W Gunning and JI Shapiro. 2009. Pseudo-sickle cell anemia. Am J Med Sci. 338:292-3.
109. Li, Z, T Cai, J Tian, JX Xie, X.Zhao, L Liu, JI Shapiro and Z Xie. 2009 NaKtide, a Na/K-ATPase-derived peptide Src inhibitor, antagonizes ouabain-activated signal transduction in cultured cells. J. Biol. Chem. 284:21066-76.
110. Tian, J, A Shidyak, SM Periyasamy, S Haller, S Oweis, , M Taleb, N El-Okdi, J Elkareh, S Gupta, OV Fedorova, CJ Cooper, Z Xie, D Malhotra, AY Bagrov and JI Shapiro. 2009. Spironolactone attenuates uremic cardiomyopathy by antagonizing the signaling of cardiotonic steroids through the Na/K-ATPase. Hypertension. 54:1313-20.
111. Jacob, A, S Khuder, N Malhotra, T Sodeman, JP Gold, D Malhotra and JI Shapiro. 2010. Prediction of mortality in ESRD patients using a feed forward neural netork developed from data submitted to the United States renal data system. Nephron. 116:c148-158.
112. Kanjwal K, CJ Cooper, R Virmani, S Haller, JI Shapiro, MW Burket, M Steffes, P Brewster, H Zhang and WR Colyer, Jr. Predictors of embolization during protected renal artery angioplasty and stenting: Role of antiplatelet therapy. Catheter Cardiovasc. Interv. 76:16-23..
113. Zhang, Z, Z Li, J Tian, W. Jiang, Y Wang, D Li, JI Shapiro, S Si and Z Xie. 2010. Identification of hydroxyxanthones as Na/K-ATPase ligands. Mol Pharmacol. 77:961-7.
114. Kasmani, R. K. Okoli, K. Narahariesetty, W. Gunning, J.I. Shapiro and S. Ratnam. 2010. Microscopic polyangiitis triggered by recurrent methicillin-resistent Staphyococcus aureus bacteremia. Int. Urol. Nephrol. 42:821-4.
115. Tian, J, S Haller, S Periyasamy, P Brewster, H Zhang, OV Fedorova, Z Xie, AY Bagrov, JI Shapiro and CJ Cooper. 2010. Renal ischemia regulates marinobufagenin release in humans. 56:914-9. PMID:20823380.
116. Kablan, A, RA Aunders, M Szkudalerk-Mikho, AJ Chin, RM Bosio, K Fujii, J Shapiro, KV Chin. 2010 Prieurianin causes weight loss in diet induced obese mice and inhibits adipogenesis in cultured preadipocytes. J. Diabetes Metab. 1:1-12.
117. Gohara, S, JI Shapiro, AN Jacob, SA Khuder, RA Gandy, PJ Metting, J Gold and J Kleshinski. 2011. Predictors of success on the United States medical licensing examinations (USMLE). TLAR 16:11-20.
118. Kolmakova, EV, OV Fedorova, AN Isachikina, GV Budny, EV Frolova, G Piecha, J Tian, D Malhotra, JI Shapiro and AY Bagrov. 2011. Endogenous cardiotonic steroids in chronic renal failure. Nephrology, Dialysis and Transplantation 26:2912-9.
119. Nikitina ER, AV Mikhalilov, ES Nikandrova, EV Frolova, AV Fadeev, VV Shman, VY Shilova, NI Tapilskaya, JI Shapiro, OV Fedorova and AY Bagrov. 2011 In preeclampsia, endogenous cardiotonic steroids induce vascular fibrosis and impair relaxation of umbilical arteries. J Hypertens. 29:769-76.
120. Haller, S. P Brewster, H Zhang, WR Colyer, Jr, JI Shapiro, and CJ Cooper. 2011. Platelet activation in patients with atherosclerotic renal artery stenosis undergoing stent revascularization. CJASN. 6:2185-91.
121. Yu, H, D Zhang, S Haller, K Kanjwal, WR Colyer, Jr, P Brewster, M Steffes, JI Shapiro, and CJ Cooper. 2011. Determinants of renal function in patients with renal artery stenosis. Vasc. Med. 20:1-8.
122. Liu, J, Y Yang, L Liu, Z Xie, DK Malhotra, B Joe, and JI Shapiro. 2011. Impaired ouabain-induced endocytosis of the Na/K-ATPase and NHE3 in proximal tubule characterizes Dahl salt-sensitive hypertension. J. Biol. Chem. 286:22806-13.
123. Li, Z, J Tian, JX Xie, T Cai, H Cui, H Ding, JI Shapiro, and Z Xie. 2011. The Na/K-ATPase mimetic pNaKtide inhibits the growth of human cancer cells. J. Biol.Chem 286:32394-403.
124. Gupta, S, D Malhotra, J Liu, Z Xie, SM Najjar and JI Shapiro. 2012. Competition between sodium pump and insulin induced endocytosis in renal epithelium: implication for blood pressure regulation. Hypertension. 59:665-72.
125. Haller, ST. EV Kolmakova, DJ Kennedy, AN Isachkina, A Shidyak, GV Budny, EV Folova, G Piecha, D Malhotra, OV Fedorova, JI Shapiro, and AY Bagrov. 2012. Monoclonal antibody against marinobufagenin reverses cardiac fibrosis in rats with chronic renal failure. Am. J. Hypertens. 10:2012-17.
126. Fedorova, L, C Gatto-Weis, S Smaili, N Khurshid, JI Shapiro, D Malhotra and T Horrigan. 2012. Down-regulation of the transcription factor snail in the placentas of patients with preeclampsia and in a rat model of preeclampsia. Reprod. Biol. Endocrinol. 10:15.
127. Liu, C, Y Bai, Y Wang, Y Sottejeau, L Liu, X Li, JB LIngrel, D Malhotra, CJ Cooper, JI Shapiro, ZJ Xie, J Tian. 2012. Reduction of Na/K-ATPase potentiates marinobufagenin-induced cardiac dysfunction and myocyte apoptosis. J. Biol. Chem. 287:16390-8.
128. Yan, Y, S Haller, A Shapiro, N Malhotra, J Tian, Z Xie, D Malhotra, JI Shapiro, and J Liu. 2012. Ouabain-stimulated trafficking regulation of the Na/K-ATPase and NHE3 in renal proximal tubule cells. Mol. Cell. Biochem. 367:175-93.
129. Li, M, L Vanella, Y Zhang, M Shi, T Takaki, JI Shapiro, S. Ikehara. 2012. Stem cell transplantation increases antioxidant effects in diabetic mice. Int. J. Biol. Sci. 8:1335-1344. PMID: 23139632.
130. Kennedy, DJ, Y Chen, W Huang, J Viterna, J Liu, K Westall, J Tian, DJ Bartlett, WHW Tang, Z Xie, JI Shapiro and RL Silverstein. 2013. CD36 and Na/K-ATPase-alpha1 form pro-inflammatory signaling loop in kidney. Hypertension. 61:216-24. PMID: 23172921.
131. Tzamaloukas, AH, D Malhotra, B Rosen, DSC Raj, G Murata and JI Shapiro. 2013. Principles of management of severe hyponatremia. JAHA. 2:e005199. PMID 23525443.
132. Drummond CA, G Budny, ST Haller, J Liu, Y Yan, Z Xie, D Malhotra, JI Shapiro and J Tian. 2013. Role of gender in the development of uremic cardiomyopathy following partial nephrectomy. J. Hypertension- Open Access. Jan31;2. doi:10.4172/2167-1095.
133. Haller, ST, P Kalra, J Ritchie, T Chrysochou, P Brewster, W He, H Yu, J Shapiro and CJ Cooper. 2013. Effect of CD40 and sCD40L on renal function and survival in patients with renal artery stenosis. Hypertension. 61:894-900. PMID:23399713.
134. Tzamaloukas, AH, Y Sun, D Mills, T Ing and JI Shapiro. 2013. Body sodium, potassium and water in peritoneal dialysis-associated hyponatremia. Peritoneal Dialysis Int. 34:253-9. PMID:24863873..
135. Vanella, L, K Sodhi, DH Kim, N Puri, M Mhaeshwari, TD Hinds Jr, L Berliner, D Goldstein, SJ Peterson, JI Shapiro and NG Abraham. 2013. Increased heme-oxygenase 1 expression decreases adipocyte differentiation and lipid accumulation in mesenchymal stem cells via upregulation of the cannoncal Wnt signaling cascade. Stem Cell Res Ther. 4:28. PMID:23497794.
136. Tzamaloukas, AH, Y Sun, NK Konstantinov, TS Ing, RI Dorin, D Malhotra, GH Murata and JI Shapiro. 2013. Principles of quantitative fluid and cation replacement in extreme hyperglycemia. Cureus. 5:e110.doi:10.7759.
137. Kim DH, N Puri, K Sodhi, JR Falck, NG Abraham, J Shapiro, ML Schwartzman. 2013. Cyhclooxygenase-2 dependent metabolism of 20-HETE increases adiposity and adipocyte enlargement in mesenchymal stem cell-derived adipocytes. J Lipid Res. 54:786-93. PMID: 23293373.
138. Fedorova, L, K Sodhi, N Puri, T Hinds, JI Shapiro and D Malhotra. 2013. Peroxisome proliferator-activated receptor delta agonist, HPP593, prevents renal necrosis under chronic ischemia. PLOS ONE. 8:e64436. PMID 23691217.
139. Sodhi K, N Puri, DH Kim, TD Hinds, LA Stechschulte, G Favero, L Rodella, JI Shapiro, D Jude, NG Abraham. 2013. PPARdelta binding to heme-oxygenase 1 promoter prevents angiotensin II – induced adipocyte dysfunction in Goldblatt hypertensive rats. Int. J. Obes. 38:456-65. PMID 23779049.
140. Haller, ST, CA Drummond, Y Yan, J Liu, J Tian, D Malhotra and JI Shapiro. 2013. Passive immunization against marinobufagenin attenuates renal fibrosis and improves renal function in experimental renal disease. Am.J.Hyperten. 27:603-9. PMID:24014658.
141. Fedorova LV, A Tamirisa, ST Haller, G Budnyy, JI Shapiro and D Malhotra. 2013. Mitochondrial impairment in the five-sixth nephrectomy model of chronic renal failure; proteomic approach. BMC Nephrology. 14:209. PMID 24090408.
142. Yan, Y, AP Shapiro, S Haller, V Katragadda, L Liu, J Tian, V Basrur, D Malhotra, Z Xie, NG Abraham, JI Shapiro and J Liu. 2013.The Involvement of Reactive Oxygen Species in a Feed-Forward Mechanism of Na/K-ATPase Mediated Signaling. J. Biol. Chem. 288:34249-58. PMID: 24121502.
143. Hinds TD Jr, K Sodhi K, C Meadows C, L Fedorova, N Puri, DH Kim, SJ Peterson, J Shapiro, NG Abraham, A Kappas. 2014. Increased HO-1 levels ameliorate fatty liver development through a reduction of heme and recruitment of FGF21. Obesity. 22:402-12.PMID:23839791.
144. Cooper CJ, Murphy TP, Cutlip DE, Jamerson K, Henrich W, Reid DM, Cohen DJ, Matsumoto AH, Steffes M, Jaff MR, Prince MR, Lewis EF, Tuttle KR, Shapiro JI, Rundback JH, Massaro JM, D'Agostino RB, and Dworkin LD. 2014. Stenting and Medical Therapy for Atherosclerotic Renal-Artery Stenosis. N.Engl.J.Med. 370:13-22. PMID: 24245566.
145. Murphy TP, CJ Cooper, DE Cutlip, A Matsumoto, K Jamerson, J Rundback, KA Rosenfield, W Henrich, J Shapiro, J Massaro, CH Yen, H Burch, C Thum, D Reid, L Dworkin. 2014. Roll in experience from the cardiovascular outcomes with renal atherosclerotic lesions (CORAL) study. J Vasc Interv Radiol. Apr;25(4):511-20. PMID:24325931.
146. Drummond, CA, G Buddny, ST Haller, J Liu, Y Yan, D Malhotra, JI Shapiro and J Tian. 2013 Gender differences in the development of uremic cardiomyopathy following partial nephrectomy: Role of progesterone. J Hypertens. 10.4172/2167-1095. PMID:24404431.
147. Drummond CA, M Sayed, KL Evans, H Shi, X Wang, ST Haller, J Liu, CJ Cooper, Z Xie, JI Shapiro, and J Tian. 2014. Reduction of Na/K-ATPase affects cardiac remodeling and increases c-kit cell abundance in partial nephrectomized mice. AJP: Heart and Circulatory Physiology. 306:H1631-43. PMID: 24748592.
148. Sun Y, D Mills, TS Ing, JI Shapiro and AM Tzamaloukas. 2014. Body sodium, potassium and water in peritoneal dialysis-associated hyponatremia. 34:253-9. PMID: 24863873.
149. Tzamaloukas AH, JI Shapiro, DS Raj, GH Murata, RH Glew and D Malhotra. 2014. Management of severe hyponatremia: infusion of hypertonic saline and desmopressin or infusion of vasopressin inhibitors? Am.J.Med.Sci. 248:432-9. PMID:25247759.
150. Khitan Z, M Harsh, K Sodhi, JI Shapiro and NG Abraham. 2014. HO-1 upregulation attenuates adipocyte dysfunction, obesity and isoprostane levels in mice fed high fructose diets. J. Nutr. Metab. Epub. PMID:25295182.
151. Miller B, B Dzwonek, A McGuffin and JI Shapiro. 2014. From LCME probation to compliance: the Marshall University Joan C Edwards School of Medicine experience. Adv. Med. Educ. Prac. 5:377-82. PMID: 255337003.
152. Cao J, PL Tsenovoy, EA Thompson, JR Falck, R Touchon, K Sodhi, R Rezzani, JI Shapiro and NG Abraham. Agonists of epoxyeicosatrenoic acids reduce infarct size and ameliorate cardiac dysfunction via activation of HO-1 and Wnt1 canonical Pathway. Prostaglandins Other Lipid Mediat. 2015: Epub: PMID: 25677507.
153. Sodhi K, N Puri, G Favero, S Sevens, C Meadows, NG Abraham, R Rezzzani, H Ansinelli, E Lebovics and JI Shapiro. 2015, Fructose mediated non-alcoholic fatty liver is attenuated by HO-1-SIRT1 module in murine hepatocytes and mice fed a high fructose diet. PLoS One 10:e0128648. PMID: 26098879.
154. Murphy TP, CJ Cooper, AH Matsumoto, DE Cutlip, KM Pensina, K Jamerson, K Tuttle, J Shapiro, R D’Agostino, J Massaro, W Henrich, LD Dworkin. 2015. Renal Artery Stent Outcomes: Effect of Baseline Blood Pressure, Stenosis Severity, and Trans-lesion Pressure Gradient. J.A.C.C. 66:2487-94.
155. Yu S, P Brewster, K Ren, W He, K Xiang, K Tuttle, K Jamerson, L Dworkin, D Cutlip, S Solomon, T Murphy, R Dagostino, W Henrich, J Shapiro and C Cooper. 2015. Stenting of atherosclerotic renal artery stenosis does not improve clinical outcomes in patients presenting with congestive heart failure, an analysis of the CORAL trial. J Hypertension. Suppl 1: e49. PMID:26102835.
156. Sodhi, K, K Maxwell, Y Yan, J Liu, MA Chaudhry, M Getty, Z Xie, NG Abraham and JI Shapiro. 2015. pNaKtide Inhibits Na/K-ATPase Reactive Oxygen Species Amplification and Attenuates Adipogenesis. Science Advances. 1:e1500781. PMID: 26601314.
157. Gullo CA, MJ McCarthy, JI Shapiro and BL Miller. 2015. Predicting medical student success on licensure exams. Med Sci Educ. 25:447-453.
158. Sodhi K, L Bracero, A Feyh, A Nichols, K Srikanthan,T Latif, D Preston, JI Shapiro, Y Elitsur. 2016. J Clin Cell Immunol. Epub PMID: 27182456.
159. Shaver A, A Nichols, E Thompson, A Mallick, K Payne, C Jones, ND Manne, S Sundaram, JI Shapiro, K Sodhi. 2016. Role of serum biomarkers in early detection of non-alcoholic steatohepatitis and fibrosis in West Virginian population. In J Med Sci. 13:161-8. PMID: 26941576.
160. Peterson SJ, L Vanella, K Gotlinger, H Jiang, SP Singh, K Sodhi, E Maher, K O’Hanlon, JI Shapiro, NG Abraham. 2016. Oxidized HDL is a potent inducer of adipogenesis and causes activation of the ang-II and 20-HETE systems in human obese females. Prostaglandins Other Lipid Mediat. 123:68-77. PMID:27179555.
161. Sodhi, K, J Hilgefort, G Banks, C Gilliam, S Stevens, HA Ansinelli, M Getty, NG Abraham, JI Shapiro and Z Khitan. 2016. Uric acid-induced adipocyte dysfunction is attenuated by HO-1 upregulation: Potential role of antioxidant therapy to target obesity. Stem Cells International. 2016:8197325. Doi:10.1155/2016/8197325.PMID: 26681956.
162. Kennedy DJ, JM Chan, D Kaw, AM Ravindaran, S Ratnam, D Malhotra and JI Shapiro. 2016. Use of surface enhanced laser desorption/ionization with time of flight (SELDI-TOF) of the urine in the assessment of acute kidney injury (AKI). Marshall Journal of Medicine 2:11. 10.18590/mjm.2016.
163. Drummond, C, M Hill, H Shi, X Fan, J Xie, S Haller, D Kennedy, J Liu, M Garrett, Z Xie, C Cooper, J Shapiro and J Tian. 2016. Na/K-ATPase signaling regulates collagen synthesis through microRNA-29-b in cardiac fibroblasts. Am.J.Physiol.-Physiol.Gen. 48:220-9. PMID 26702050.
164. Tuttle, KR, LD Dworkin, W Henrich, BA Greco, M Steffes, S Tobe, JI Shapiro, K Jamerson, K Pencina, JM Massaro, RB D’Agostino, DE Cutlip, TP Murphy, and CJ Cooper. 2016. Effects of stenting for atherosclerotic renal artery stenosis on kidney function in the CORAL trial. C.J.A.S.N. 11:1180-8. PMID: 27225988.
165. Yan, Y, AP Shapiro, B Mopidevi, MA Chaudhry, K Maxwell, S Haller, C Drummond, DJ Kennedy, J Tian, D Malhotra, Z Xie, J Shapiro and J Liu. 2016. Protein carbonylation of an amino acid residue of the Na/K-ATPase a1 subunit regulates Na/K-ATPase signaling and sodium transport in renal proximal tubule cells. JAHA: 5:e003675, PMID: 27613772.
166. Murphy TP, Cooper CJ, Pencina KM, D'Agostino R, Massaro J, Cutlip DE, Jamerson K,Matsumoto AH, Henrich W, Shapiro JI, Tuttle KR, Cohen DJ, Steffes M, Gao Q, Metzger DC,Abernethy WB, Textor SC, Briguglio J, Hirsch AT, Tobe S, Dworkin LD. 2016. Relationship of Albuminuria and Renal Artery Stent Outcomes: Results from the CORAL Randomized Clinical Trial (Cardiovascular Outcomes With Renal Artery Lesions). Hypertension. 68:1145-52. PMID: 27647847.
167. Haller, ST, S Kumarasamy, DA Folt, LM Wuescher, S Stepkowski, M Karamchandani, H Waghulde, B Mell, MA Chaudhry, K Lessar, S Upadhyaya, CA Drummond, J Tian, W Filipiak, TL Saunders, JI Shapiro, B Joe, CJ Cooper. 2016. Targeted Disruption of Cd40 in a Genetically Hypertensive Rat Model Attenuates Renal Fibrosis and Proteinuria, Independent of Blood Pressure, in Hypertensive Nephropathy. Kidney Int. pii:S0085-2538(16)30443-4. PMID: 27692815.
168. Haller ST, Y Yan, CA Drummond, J Xie, J Tian, DJ Kennedy, VY Shilova, Z Xie, J Liu, CJ. Cooper, D Malhotra, JI Shapiro, OV Fedorova, AY Bagrov. 2016. Rapamycin Attenuates Cardiac Fibrosis in Experimental Uremic Cardiomyopathy by Reducing Marinobufagenin Levels and Inhibiting Downstream Pro-fibrotic Signaling. JAHA: 5(10).pii:e004106. PMID: 27694325.
169. Liu J, J Tian, M Chaudhry, K Maxwell, Y Yan, X Wang, PT Shah, AA Khawaja, R Martin, TJ Robinette, A El-Hamdani, MW Dodrill, K Sodhi, CA Drummond, ST Haller, DJ Kennedy, NG Abraham, Z Xie and JI Shapiro. 2016. Attenuation of Na/K-ATPase Mediated Oxidant Amplification with pNaKtide Ameliorates Experimental Uremic Cardiomyopathy. Sci.Rep. 6: Article number 24592. doi:10.1038/srep34592. PMID: 27698370.
170. Shah PT, Martin R, Sanabria J, Khitan Z, Santhanam P, Sodhi K, Abraham NG and Shapiro JI. 2016. Adiposity Predicts Pulse Pressure in Subjects with Chronic Kidney Disease: Data from the Modification of Diet in Renal Disease. J.Cardiol.Curr.Res. 7:00240.
171. Christopher Drummond, Laura Crotty Alexander, Steven Haller, Xiaoming Fan, Jeffrey Xie, David Kennedy, Jiang Liu, Yanling Yan, Dawn-Alita Hernandez, Denzil Mathew, Christopher Cooper, Joseph Shapiro, and Jiang Tian. 2016. Cigarette Smoking Causes Epigenetic Changes Associated With Cardiorenal Fibrosis. Physiol.Genomics. 48:950-60. PMID: 27789733.
172. Alaini A Malhotra D Rondon-Berrios H Argyropoulos C Khitan ZJ Raj D Rohrscheib M Shapiro JI Tzamaloukas AH. 2017. Establishing the presence or absence of chronic kidney disease. Uses and limitations of formulas estimating the glomerular filtration rate. World J. Method. In press.
173. Komal Sodhi, Krithika Srikanthan, Perrine Goguet-Rubio, Alexandra Nichols, Amrita Mallick, Athar Nawab, Rebecca Martin, Preeya T. Shah, Muhammad Chaudhry, Saroj Sigdel, Mehiar El-Hamdani, Jiang Liu, Zijian Xie, Nader G. Abraham, and Joseph I. Shapiro. 2017. pNaKtide Attenuates Steatohepatitis and Atherosclerosis by Blocking Na/K-ATPase/ROS Amplification in Mouse Models of Metabolic Syndrome. Sci. Rep. 7”193. doi 10.1038/s41598-017-00306-5. PMID: 28298638.
174. Drummond CA, Brewster PS, He W, Ren K, Xie Y, Tuttle KR, Haller ST, Jamerson K, Dworkin LD, Cutlip DE, Murphy TP, D'Agostino RB Sr, Henrich WL, Tian J, Shapiro JI, Cooper CJ. 2017. Cigarette smoking and cardio-renal events in patients with atherosclerotic renal artery stenosis. PLoS One 12:E0173562 doi:10.137/journale.pone.0173562. PMID: 28306749.
175. Santhanam P, Shapiro JI, Khitan Z. 2017. Association between dietary potassium, body mass index, and proteinuria in normotensive and hypertensive individuals: Results from the Modification of Diet in Renal Disease study baseline data. J. Clin. Hypertens. 19(5):558-559. doi: 10.1111/jch.13000. PMID: 28370870.
176. Gouget-Rubio P, RL Klug, DL Sharma, K Srikanthan, N PUri, VH Lakhani, A Nichols, KM O’Hanlon, NG Abraham, JI Shapiro, K Sodhi. Existance of a strong correlation of biomarkers and miRNA in females with metabolic syndrome and obesity in a population of West Virginia. In J Med Sci. 14:543-553. PMID: 28638270.
177. Loudin S, J Werthammer, L Prunty, S Murray, J Shapiro and T Davies. 2017. A Management Strategy that Reduces NICU Admissions and Decreases Charges from the Front Line of the Neonatal Abstinence Syndrome Epidemic. J.Perinatol. 37(10):1108-1111. doi: 10.1038/jp.2017.101. PMID: 28682317.
178. Cao J, S Singh, J McClung, G Joseph, L Vanella, I Barbagallo, H Jiang, J Falck, M Arad, J Shapiro, and N Abraham. 2017. EET intervention on Wnt1, NOV, and HO-1 signaling prevents obesity induced cardiomyopathy in obese mice. AJP-Heart. 313(2):H368-H380. PMID:28576832.
179. Khitan Z, AP Shapiro, PT Shah, JR Sanabria, P Santhanam, K Sodhi, NG Abraham and JI Shapiro. Predicting adverse outcomes in chronic kidney disease using machine learning methods: data from the modification of diet in renal disease. Marshall Journal of Medicine. 10.18590/mjm.2017. vol3. Iss 4.10
180. Sharma DL, Lakhani HV, Klug RL, Snoad B, El-Hamdani R, Shapiro JI, Sodhi K. Investigating Molecular Connections of Non-alcoholic Fatty Liver Disease with Associated Pathological Conditions in West Virginia for Biomarker Analysis. J Clin Cell Immunol. 2017 Oct;8(5). pii: 523. doi: 10.4172/2155-9899.1000523. Epub 2017 Sep 29. PubMed PMID: 29177105; PubMed Central PMCID: PMC5701750.
181. Wang X, Chaudhry MA, Nie Y, Xie Z, Shapiro JI, Liu J. A Mouse 5/6th
Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy. J Vis Exp. 2017 Nov 7;(129). doi: 10.3791/55825. PubMed PMID: 29155790.
182. Xie JX, Zhang S, Cui X, Zhang J, Yu H, Khalaf FK, Malhotra D, Kennedy DJ, Shapiro JI, Tian J, Haller ST. Na/K-ATPase/src complex mediates regulation of CD40 in renal parenchyma. Nephrol Dial Transplant. 2017 Dec 22. doi: 10.1093/ndt/gfx334. [Epub ahead of print] PubMed PMID: 29294050.
183. Khitan ZJ, Tzamaloukas AH, Brodsky S, Shapiro JI. Dihydropyridine calcium channel blockers in the elderly with diabetic nephropathy: Are they safe? J Clin Hypertens (Greenwich). 2018 Jan;20(1):203-204. doi: 10.1111/jch.13158. Epub 2018 Jan 6. PubMed PMID: 29316147.
184. Ogu I, Shweihat YR, Shapiro JI, Khitan ZJ. Stroke volume and proteinuria in obesity-related glomerulopathy: potential role in pathogenesis and choice of antihypertensive regimen. J Clin Hypertens (Greenwich). 2018 Feb 15. doi: 10.1111/jch.13245. [Epub ahead of print] PubMed PMID: 29447440.
185. Khitan ZJ, Shweihat YR, Tzamaloukas AH, Shapiro JI. Dietary potassium and cardiovascular profile. Results from the modification of diet in renal disease dataset. J Clin Hypertens (Greenwich). 2018 Mar;20(3):611-612. doi: 10.1111/jch.13207. Epub 2018 Feb 19. PubMed PMID: 29457341.
186. Khitan ZJ, Kheetan MM, Shapiro JI. PURE is not so pure when it comes to dietary sodium and cardiovascular events! J Clin Hypertens (Greenwich). 2018 Mar 30. doi: 10.1111/jch.13267. [Epub ahead of print] PubMed PMID: 29603554.
187. Roumelioti ME, Ing TS, Glew RH, Khitan ZJ, Sun Y, Malhotra D, Raj DS, Agaba EL, Murata GH, Shapiro JI and Tzmaloukas AH. 2018. Principles of quantitative water and electrolyte replacement of losses from osmotic diuresis. Int Urol Nephrol 50:1263-70. PMID: 29511980.
188. Gress, Todd W.; Denvir, James; and Shapiro, Joseph I. (2018) Effect of Removing Outliers on Statistical Inference: Implications to Interpretation of Experimental Data in Medical Research, Marshall Journal of Medicine: Vol. 4: Iss. 2, Article 9. DOI:
189. Sodhi K, Nichols A, Mallick A, Klug RL, Wang X, Srikanthan K, Goguet-Rubio P, Nawab A, Pratt R, Lilly MN, Sanabria JR, Xie Z, Abraham NG and Shapiro JI. 2018. The Na/K-ATPase oxidant amplification loop regulates aging. Sci.Rep. 8:9721.doi:10.1038/s41598-018-26768-9. PMID:29946187.
190. Wang W, Shapiro JI. Quantum Modeling: A Bridge between the Pumping and Signaling Functions of Na/K-ATPase. Int J Mol Sci. 2018 Aug 9;19(8). pii: E2347. doi: 10.3390/ijms19082347. PubMed PMID: 30096926.
191. Bartlett DE, Miller RB, Thiesfeldt S, Lakhani HV, Khanal T, D Pratt R, Cottrill CL, Klug RL, Adkins NS, Bown PC, Nease DB, Shapiro JI, Sodhi K. Uremic Toxins Activates Na/K-ATPase Oxidant Amplification Loop Causing Phenotypic Changes in Adipocytes in In Vitro Models. Int J Mol Sci. 2018 Sep 10;19(9). pii: E2685. doi: 10.3390/ijms19092685. PMID:30201874.
192. Grigorova YN, Wei W, Petashevskaya N, Zernetkina V, Juhasz O, Fenner R, Gilbert C, Lakatta EG, Shapiro JI, Bagrov AY, Fedorova O. 2018. Dietary sodium restriction reduces arterial stiffness. Vascular TGFb dependent fibrosis and marinobufagenin in young normotensive rats. Int J Mol Sci. 19:E3168. doi: 10.3390/ijms 19103168. PMID 30326586.
193. Lakhani HV, Khanal T, Gabi A, Yousef G, Alam MB, Sharma D, Aljoudi H, Puri N, Thompson E, Shapiro JI, Sodhi K. 2018. Developing a panel of biomarkers and miRNA in patients with myocardial infarction for early intervention strategies of heart failure in West Virginian population. Plos One. 12:e0205329. PMID 30356307.
194. Khitan Z, AD Jacob, C Balentine, AN Jacob, JR Sanabria and JI Shapiro. 2018. Predicting adverse outcomes in end stage renal disease: Machine learning applied to the United States renal data system. Marshall Journal of Medicine: Vol 4 Issue 4 Article 8. Doi: .
195. Yousef GM.; Poe J; Killmer C; Edris B; Mader J; Thompson EA; Snavely D; Cansino S; Shapiro, JI and Studeny MA (2018) "Outcomes of Transcutaneous Aortic Valve Replacement among high risk WV sample population.," Marshall Journal of Medicine: Vol. 4: Issue. 4, Article 6. DOI:
196. Lakhani HV, Sharma D, Dodrill MW, Nawab A, Sharma N, Cottrill CL, Shapiro JI, Sodhi K. Phenotypic Alteration of Hepatocytes in Non-Alcoholic Fatty Liver Disease. Int J Med Sci. 2018 Oct 20;15(14):1591-1599. doi: 10.7150/ijms.27953. eCollection 2018. Review. PubMed PMID: 30588181; PubMed Central PMCID: PMC6299410.
197. Peterson SJ, Shapiro JI, Thompson E, Singh S, Liu L, Weingarten JA, O'Hanlon K, Bialczak A, Bhesania SR, Abraham NG. Oxidized HDL, Adipokines, and Endothelial Dysfunction: A Potential Biomarker Profile for Cardiovascular Risk in Women with Obesity. Obesity (Silver Spring). 2019 Jan;27(1):87-93. doi: 10.1002/oby.22354. PubMed PMID: 30569635.
Invited Review Articles and Book Chapters:
1. Shapiro, J.I., D.C.H. Harris, and R.W. Schrier. 1985. Pharmacological therapy of acute renal failure. In Serono Symposium on Drugs and the Kidney. G. Remmuzzi, editor. Raven Press, New York. 121-159.
2. Shapiro, J.I. and R.J. Anderson. 1984. Urinary diagnostic indices in acute renal failure. AKF Nephrol. Lett. 1:13-17.
3. Shapiro, J.I., and R.W. Schrier. 1985. Clinical aspects of acute renal failure. In Proceedings of the 30th Congress of the Japanese Society of Dialysis Therapeutics. Raven Press, New York. 45-60.
4. Schrier, R.W., and J.I. Shapiro. 1985. Cellular events in ischemic acute renal failure. In Proceedings of the 6th Asian Pacific Colloquium in Nephrology. Raven Press, New York. 22-38.
5. Schrier, R.W., and J.I. Shapiro. 1985. Drug induced acute renal failure. In Proceedings of the 6th Asian Pacific Colloquium in Nephrology. Raven Press, New York.
6. Chan, L., and J.I. Shapiro. 1987. NMR in the investigation and differential diagnosis of acute renal failure. Ann. N. Y. Acad. Sci. 508:420-421.
7. Chan, L., C.E. Haug, and J.I. Shapiro. 1987. Groin heart transplantation in a model for NMR study. Ann. N. Y. Acad. Sci. 508:402-420.
8. Schrier, R.W., R. Cosby, B. Yee, J. Durr, M. Nakamoto, L. Chan, and J.I. Shapiro. 1987. Atrial natriuretic factor: physiologic and clinical aspects. Asian-Pac. Cong. Neph. 3:137-143.
9. Shapiro, J.I. and R.J. Anderson. 1987. Sodium depletion states in Advances in Nephrology by Brenner BM and Stein JH. Churchill Livingston, NY.
10. Shapiro, J.I., and R.W. Schrier. 1988. Renal and electrolyte disorders. In Clinical Internal Medicine. R.W. Schrier, editor. Little Brown, Boston/Toronto. 125-178.
11. Schrier, R.W., D.C.H. Harris, J.I. Shapiro, L. Chan, and C. Carmelo. 1988. Tubular hypermetabolism as a factor in the progression of chronic renal failure. Am. J. Kid. Dis. 12:243-249.
12. Chan L. and J.I. Shapiro. Magnetic resonance spectroscopy study of renal transplant. 1989. Renal Physiol. Biochem. 12:141-143.
13. Chan, L., and J.I. Shapiro. Magnetic resonance in the diagnosis and investigation of renal disease. 1989. Renal Failure 11:79-89.
14. Hutchison, R.B. and J.I. Shapiro. 1991. Measurement of intracellular sodium with NMR methods. Con. Mag. Reson. 3:215-236.
15. Shapiro, J.I. and R.W. Schrier. 1992. Etiology, pathogenesis and management of renal failure. In Campbell's Textbook of Urology. P.C. Walsh, A. B. Retik, T.A. Stamey and E. D. Vaughan editors. W.B. Saunders Company, Philadelphia.
16. Shapiro, J.I. and W.D. Kaehny. 1992. Pathogenesis and management of metabolic acidosis and alkalosis. in Renal and Electrolyte Disorders IIIrd Edition. ed. by R. W. Schrier, Little Brown, Boston.
17. Shapiro, J.I. 1992. Renal and electrolyte disturbances. in Critical Care Secrets ed by P. Parsons. Mosby Books, Philadelphia.
18. Malhotra, D. and J.I. Shapiro. 1993. Measurement of intracellular pH with NMR methods. Con. Mag. Reson. 5:123-150.
19. Schrier,R.W., J.I. Shapiro, L. Chan, D.C.H. Harris. 1994. Increased nephron oxygen consumption: Potential role in progression of chronic renal failure. Am.J.Kid.Dis. 23:176-182.
20. Malhotra, D. and J.I. Shapiro. 1996. Pathogenesis and management of lactic acidosis. Concepts in Critical Care. 2:439-448.
21. Yucha C.B. and J.I. Shapiro. Lippicotts Prim.Care. Pract. 1997. Acute renal failure. Recognition and prevention. 1:388-98.
22. Edelstein, C., Shapiro, J.I. and R.W. Schrier. 1997. Etiology, pathogenesis and management of renal failure. In Campbell's Textbook of Urology. W.B. Saunders Company, Philadelphia.
23. Shapiro, J.I. and W.D. Kaehny. 1997. Pathogenesis and management of metabolic acidosis and alkalosis. in Renal and Electrolyte Disorders IVth Edition. ed. by R. W. Schrier, Little Brown, Boston.
24. Venkatasen, J., J.I. Shapiro, and R.W. Hamilton. 1998. Dialysis considerations in the patient with acute renal failure. In Principles and Practice of Hemodialysis. ed. By W. Henrich. Mosby, Boston.
25. Venkatasen, J.,R.W. Hamilton and J.I. Shapiro. 1998. Dialysis considerations in the patient with chronic renal failure. In Principles and Practice of Hemodialysis. ed. By W. Henrich. Mosby, Boston.
26. Shapiro, J.I. 2002. Hypertension and Diabetic Nephropathy. World Hypertension League Website (mco.edu/org/whl/prof.html#art).
27. Ravindaran, A., and J.I. Shapiro 2002. Acute renal failure. In Critical Care Secrets. 3rd Edition. ed by P. Parsons. Mosby, Boston.
28. Shapiro, J.I. and W.D. Kaehny. 2002. Pathogenesis and management of metabolic acidosis and alkalosis. in Renal and Electrolyte Disorders Vth Edition. ed. by R. W. Schrier, Little Brown, Boston.
29. Liu, J. and J.I. Shapiro. Endocytosis and signal transduction. 2003. Biol. Res.Nurs. 5:117-128
30. Nucklos, R. and J.I. Shapiro. Arthur Guyton, sodium and hypertension. Biol. Res.Nurs. 5:77-78.
31. Kaw, D. and J.I. Shapiro. Simple acid-base disorders: Metabolic acidosis. In Nephrology in 30 days 1st edition ed by R.F. Reilly and M.A. Perazella. 2005.
32. Kaw, D. and J.I. Shapiro. Simple acid-base disorders: Metabolic alkalosis. In Nephrology in 30 days 1st edition ed by R.F. Reilly and M.A. Perazella. 2005.
33. Yoon, Y. and J.I. Shapiro. Respiratory and mixed acid-base disorders.In Nephrology in 30 days 1st edition ed by R.F. Reilly and M.A. Perazella. 2005.
34. Bagrov, A.Y. and J.I. Shapiro. Introduction in Role of the Na/K-ATPase in Health and Disease. Ed by Bagrov, A.Y. and J.I. Shapiro. 2005. Frontiers in Bioscience. 10:2020-2025.
35. Mohmand, B., D. Malhotra and J.I. Shapiro. 2005. Role of cardiotonic steroids in uremic cardiomyopathy in Role of the Na/K-ATPase in Health and Disease. Ed by Bagrov, A.Y. and J.I. Shapiro. Frontiers in Bioscience. 10:2036-2044.
36. Shapiro, J.I. Hyperkalemia and cardiac hypertrophy: how does it work? 2005. Editorial Commentary. Hypertension 46:477-8.
37. Priyadarshi, A. and J.I. Shapiro. 2006. Mechanisms of EPO resistance. Seminars in Nephrology. 19: 273-278.
38. Kaw, .D. and J.I. Shapiro. 2007. Acute renal failure. In Critical Care Secrets. 4th Edition. ed by P. Parsons. Mosby, Boston..
39. Kennedy, D.J., D. Malhotra and J.I. Shapiro. 2006. Molecular insights into uremic cardiomyopathy: cardiotonic steroids and Na/K-ATPase signaling. Cell.Mol.Biol. 52(8):3-14.
40. Lien, Y.H. and J.I. Shapiro. 2007. Hyponatremia: clinical diagnosis and management. Am. J. Med. 120:653-658.
41. Liu, J. and J.I. Shapiro. 2007. Regulation of sodium pump endocytosis by cardiotonic steroids: molecular mechanisms and physiological implications. Pathophysiology. 14: 171-181.
42. Kaw, .D. and J.I. Shapiro. 2008. Metabolic Acidosis: B.M.J. Point of Care.
43. Kaw, .D. and J.I. Shapiro. 2008. Metabolic Alkalosis: B.M.J. Point of Care.
44. Bagrov AY and J.I.Shapiro. 2008. The roles and potential targeting of endogenous cardiotonic steroids in renal and cardiovascular disease. Nature Clinical Practice: Nephrology. 4:378-92.
45. Fedorova, O., JI Shapiro and AY Bagrov. 2009. Endogenous cardiotonic steroids: Physiology, pharmacology and novel therapeutic targets. Pharm. Rev. 61: 9-38.
46. Ratnam, S and J.I. Shapiro. 2010. Pathogenesis and management of metabolic acidosis and alkalosis. in Renal and Electrolyte Disorders VIth Edition. ed. by R. W. Schrier, Little Brown, Boston.
47. Liu, J and J.I. Shapiro. 2010. The Na/K-ATPase and signaling. In Endocytosis, Structural Components, Functions and Pathways. Nova Science Publishers, Inc.
48. Fedorova, O., JI Shapiro and AY Bagrov. 2010. Endogenous cardiotonic steroids and hypertension. Biochim. Biophys. Acta. 1802:1230-6..
49. Shapiro, J.I. and J. Tian. 2011. Editorial Focus. Signaling through the Na/K-ATPase: Implications for Cardiac Fibrosis. Am.J.Physiol.-Heart and Circ. Physiol. 300:H29-30.
50. Gohara, S, D Malhotra, S Vetteth, and JI Shapiro. 2011. Cardiotonic steroids, hypertension and cardiovascular disease. In Advances in Renal Physiology
51. Gohara, S, D Malhotra, S Vetteth, and JI Shapiro. 2011. Cardiotonic steroids, hypertension and cardiovascular disease. Current Hypertension Reviews.
52. Vetteth, S. S. Gohara, and J.I.Shapiro. 2012. Cardiotonic steroids and cardiac fibrosis. In Cardiomyopathies. Ed by J. Veselka. In Tech. Rojeka, Croatia.
53. Liu, J, DJ Kennedy, Y Yan, and JI Shapiro. 2012. Reactive oxygen species modulation of Na/K-ATPase regulates fibrosis and renal proximal tubular sodium handling. Int. J Nephrol. 2012:381320. PMID: 2251831.
54. Joe, B. and JI Shapiro. 2012. Molecular mechanisms of experimental salt-sensitive hypertension. JAHA. 1:e002121. PMID:23130148.
55. Franks, A.. and J.I. Shapiro. 2012. Simple acid-base disorders: Metabolic acidosis. In Nephrology in 30 days 2nd edition ed by R.F. Reilly and M.A. Perazella.
56. Franks, A. and J.I. Shapiro. 2012. Simple acid-base disorders: Metabolic alkalosis. In Nephrology in 30 days 2nd edition ed by R.F. Reilly and M.A. Perazella.
57. Franks, A. and J.I. Shapiro. 2012. Respiratory and mixed acid-base disorders.In Nephrology in 30 days 2nd edition ed by R.F. Reilly and M.A. Perazella.
58. Shapiro, J.I. and L. Dial. 2012. How safe is uninephrectomy? Hypertension 60:1282-4. PMID: 23071125.
59. Xie, J., LD Dial and JI Shapiro. 2013. Na/K-ATPase signaling and the tradeoff between natriuresis and cardiac fibrosis. In Cardiomyopathy. Ed by J Veslka. In Tech. Rjeska, Croatia.
60. Dial, L. J Xie and JI Shapiro. 2013. The tradeoff between natriuresis and cardiac and renal fibrosis. J. Hypertension-Open Access.
61. Ahmed, S and JI Shapiro. 2013. Sleep Apnea and Hypertension. Cureus.
62. Dial, L, J Liu and JI Shapiro. 2014. Cardiotonic steroids in adaptation to dietary salt intake. Clinical Current Pharmacology. 9:298-309. PMID:24219001.
63. Xie JX, AP Shapiro and JI Shapiro. 2014.The trade-off between dietary salt and cardiovascular disease: a role for Na/K-ATPase signaling? Frontiers in Endocrinology. 5:97. PMID:25101054.
64. Wehner P and JI Shapiro. 2014. Renal denervation to treat cardiac fibrosis? J. Am. Heart Assoc. 3:e001556. PMID: 25516440.
65. Maxwell, K, P Shah and JI Shapiro. 2015. The plasmalemmal Na/K-ATPase: An amplifier for reactive oxygen species? J Hypertens 4:1000197. Doi:10.4172/2167-1095.1000197.
66. Shah P, K Maxwell and JI Shapiro. 2015. Dashing away hypertension. World J Hypertens. 5:119-128. doi:10.5494/wjh.v5.i4.119.
67. Khitan, Z, DS Raj, D Malhotra, AH Tzamaloukas and JI Shapiro. 2015. Alkali Therapy for Lactic Acidosis. Marshall Journal of Medicine. DOI:
68. Krithika Srikanthan, Andrew Feyh, Haresh Visweshwar, Joseph I.Shapiro, Komal Sodhi 2015. Systematic Review of Metabolic Syndrome Biomarkers: A Panel for Early Detection, Management, and Risk Stratification in the West Virginian Population. Int.J. Med. Sci. 13:25-38. PMID:26816492.
69. Shah, PT, AP Shapiro, Z Khitan, P Santhanam, and JI Shapiro. 2015. Why does obesity lead to hypertension. Marshall Journal of Medicine. In Press.
70. Xie, Z and JI Shapiro. 2016. Na/K-ATPase amplification of oxidant stress: a universal but unrecognized clinical target. Marshall Journal of Medicine. 2:4, 10.18590/mjm.2016.
71. Khitan, Z and J.I. Shapiro. 2016. Pathogenesis and management of metabolic acidosis and alkalosis. in Renal and Electrolyte Disorders VIIth Edition. ed. by R. W. Schrier, Little Brown, Boston (in press).
72. Argyropoulos, C, H Rondon-Berrios, DS Raj, D Malhotra, EI Agaba, M Rohrscheib, Z Khitan, GH Murata, JI Shapiro, and AH Tzamaloukas. 2016. Hypertonicity: pathophysiologic concept and experimental studies. Cureus 8:e596. PMID:27382523.
73. Feyh A, L Bracero, HV Lakhani, P Santhanam, JI Shapiro, Z Khitan and K Sodhi. Role of dietary components in modulating hypertension. J Clin Exp Cardiolog. Epub. PMID: 27158555
74. Yan Y, JI Shapiro. 2016. The physiological and clinical importance of sodium potassium ATPase in cardiovascular diseases. Curr Opin Pharmacol. 43-9 EPUB. PMID: 26891193.
75. Srikanthan K, JI Shapiro, K Sodhi. 2016. The role of Na/K-ATPase signaling in oxidative stress related to obesity and cardiovascular disease. Molecules. 3:e1172. PMID: 27598118.
76. Shah PT, R Martin, Y Yan, JI Shapiro and J Liu. 2016. Carbonlylation modification regulates Na/K-ATPase signaling and salt sensitivity: A review and a hypothesis. Front. Physiol. 7:256. PMID:27445847.
77. Martin R, JI Shapiro. 2016. Role of adipocytes in hypertension. World J. Hypertens. 6:66-75, doi:10.5494/wj.v6.i2.66.
78. Rondon-Berrios H, Argyropoulos C, Ing TS, Raj DS, Malhotra D, Agaba EI, Rohrscheib M, Khitan ZJ, Murata GH, Shapiro JI, Tzamaloukas AH. 2017. Hypertonicity: Clinical entities, manifestations and treatment. World J. Nephrol. 6:1-13. PMID: 28101446.
79. Liu J, Yan Y, Nie Y, Shapiro JI. 2017. Na/K-ATPase Signaling and Salt Sensitivity: The Role of Oxidative Stress. Antioxidants. 6:E18. PMID: 28257114.
80. Shapiro JI. 2017. Education of Nurse Practitioners and Physician Assistants. What Role, If Any, for Physicians in Determining Their Scope of Practice? Marshall Journal of Medicine Vol 3: Article 3.
81. Wang X, J Liu, CA Drummond and JI Shapiro. 2017. Sodium potassium adenosine triphosphatase (Na/K-ATPase) as a therapeutic target for uremic cardiomyopathy. Expert Opin.Ther.Targets. 21(5):531-541. PMID: 28338377.
82. Khitan ZJ, JI Shapiro. 2017. Association between high density lipoprotein cholesterol and hyponatremia: is something else low? Am. J. Med. EPUB. PMID: 28729080.
83. Nawab A, A Nichols, R Klug, JI Shapiro, K Sodhi. 2017. Spin trapping: a review for the study of obesity related oxidative stress and Na/K-ATPase. J Clin Cell Immunol. EPUB PMID: 28815154.
84. Mansoor K, Kheetan M, Shahnawaz S, Shapiro AP, Patton-Tackett E, Dial L, Rankin G, Santhanam P, Tzamaloukas AH, Nadasdy T, Shapiro JI, Khitan ZJ. Systematic review of nephrotoxicity of drugs of abuse, 2005-2016. BMC Nephrol. 2017 Dec 29;18(1):379. doi: 10.1186/s12882-017-0794-0. PubMed PMID: 29287591; PubMed Central PMCID: PMC5747941.
85. Roumelioti ME, Glew RH, Khitan ZJ, Rondon-Berrios H, Argyropoulos CP, Malhotra D, Raj DS, Agaba EI, Rohrscheib M, Murata GH, Shapiro JI, Tzamaloukas AH. Fluid balance concepts in medicine: Principles and practice. World J Nephrol. 2018 Jan 6;7(1):1-28. doi: 10.5527/wjn.v7.i1.1. Review. PubMed PMID: 29359117; PubMed Central PMCID: PMC5760509.
86. Liu J, Lilly MN, Shapiro JI. Targeting Na/K-ATPase Signaling: A New Approach to Control Oxidative Stress. Curr Pharm Des. 2018 Jan 9. doi: 10.2174/1381612824666180110101052. [Epub ahead of print] PubMed PMID: 29318961.
87. Bartlett DE, Miller RB, Thiesfeldt S, Lakhani HV, Shapiro JI, Sodhi K. The
Role of Na/K-ATPase Signaling in Oxidative Stress Related to Aging: Implications in Obesity and Cardiovascular Disease. Int J Mol Sci. 2018 Jul 23;19(7). pii: E2139. doi: 10.3390/ijms19072139. Review. PubMed PMID: 30041449; PubMed Central PMCID: PMC6073138.
88. Pratt RD, Brickman CR, Cottrill CL, Shapiro JI, Liu J. The Na/K-ATPase Signaling: From Specific Ligands to General Reactive Oxygen Species. Int J Mol Sci. 2018 Sep 1;19(9). pii: E2600. doi: 10.3390/ijms19092600. PMID:30200500
89. Wang X, Shapiro JI. Evolving concepts in the pathogenesis of uremic cardiomyopathy. Nature Reviews Nephrology. 2018. In Press.
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