Pancreatic tumour cohort



Get Data Out: Pancreatic cancers26th April 2021 Sally Vernon sally.vernon@.uk Charlie Turner charlie.turner@.ukThe Get Data Out programme routinely publishes cancer statistics produced by PHE in a consistent Standard Output table - a table that collects patients into groups with common characteristics, and then publishes information such as incidence, treatment rates, survival and routes to diagnosis for these standard groups. This document sets out the definitions of the cohort and groups for Get Data Out tables for the 2021 release of data on pancreatic cancer between 2013 and 2018.Pancreatic tumour cohortThe cohort of pancreatic tumours used for Get Data Out is all tumours coded in ICD-10 to C25.Tumour TypeTumours were classified as Carcinoma, Neuroendocrine and Other by ICD-O-3 morphology code as documented in the Appendix. The Other group was very small (usually fewer than 10 tumours per year, less than 0.1% of all tumours) and hence was combined with the Carcinoma group.Classifications were created with Melissa Matz at LSHTM and Dr Brian Rous at NCRAS.Stage The large group of malignant tumours, “Carcinoma and Other”, are then split by stage, intoStage 1-2Stage 3Stage 4Stage unknownPlease note that the staging system for these pancreatic cancers changed from TNM 7 to TNM 8 between 2017 and 2018 diagnoses. We believe that this changing definition reduces the number of stage 2 tumours and increases the number of stage 3 tumours, and so care must be taken if analysing the GDO data as a time series – the decrease in stage 1-2 tumours is being driven at least in part by the coding artefact of the changing stage system.Age The ideal is to split into: <5050-5960-6970-7980+This is possible for the larger groups. Where a full partition is not possible, groups are combined to make the group size large enough (e.g. ending with 70+, not 80+, or <60 instead of <50)RegionWhere numbers allow (i.e. in patients aged over 60 in carcinomas of pancreas) the cohort is partitioned into 4 regions, North of England, South of England, Midlands and East of England, and London. Patients are assigned to a cohort by their postcode at diagnosis and the National Statistics Postcode Lookup. Regions are defined based on the NHS regions in 2017, which were current when this partition was devised, and have been kept steady to provide a timeseries.GenderWhere numbers allow the data is then split into Male and Female.AppendixMorphology-tumour type look-up for tumours in pancreatic cancer cohortMorphology (ICD-O-3)Morphology NameGet Data Out Tumour Type8000Neoplasm, malignantCarcinoma and Other8001Tumour cells, malignantCarcinoma and Other8002Malignant tumour, small cell typeCarcinoma and Other8003Malignant tumour, giant cell typeCarcinoma and Other8004Malignant tumour, fusiform cell typeCarcinoma and Other8010Carcinoma NOSCarcinoma and Other8011Epithelioma, malignantCarcinoma and Other8012Large cell carcinoma NOSCarcinoma and Other8013Large cell neuroendocrine carcinomaNeuroendocrine8014Large cell carcinoma with rhabdoid phenotypeCarcinoma and Other8020Carcinoma, undifferentiated NOSCarcinoma and Other8021Carcinoma, anaplastic NOSCarcinoma and Other8022Pleomorphic carcinomaCarcinoma and Other8030Giant cell and spindle cell carcinomaCarcinoma and Other8031Giant cell carcinomaCarcinoma and Other8032Spindle cell carcinomaCarcinoma and Other8033Pseudosarcomatous carcinomaCarcinoma and Other8034Polygonal cell carcinomaCarcinoma and Other8035Carcinoma with osteoclast-like giant cellsCarcinoma and Other8040Tumorlet, NOSCarcinoma and Other8041Small cell carcinoma NOSNeuroendocrine8043Small cell carcinoma, fusiform cellNeuroendocrine8044Small cell carcinoma, intermediate cellNeuroendocrine8046Non-small cell carcinomaCarcinoma and Other8050Papillary carcinoma NOSCarcinoma and Other8070Squamous cell carcinoma NOSCarcinoma and Other8071Squamous cell carcinoma, keratinizing NOSCarcinoma and Other8072Squamous cell carcinoma, large cell, nonkeratinizingCarcinoma and Other8075Squamous cell carcinomaCarcinoma and Other8083Basaloid squamous cell carcinomaCarcinoma and Other8090Basal cell carcinoma, NOSCarcinoma and Other8120Transitional cell carcinomaCarcinoma and Other8130 Papillary transitional cell carcinomaCarcinoma and Other8140Adenocarcinoma NOSCarcinoma and Other8141Scirrhous adenocarcinomaCarcinoma and Other8143Superficial spreading adenocarcinomaCarcinoma and Other8144Adenocarcinoma, intestinal type? Carcinoma and Other8145Carcinoma, diffuse type? Carcinoma and Other8148Glandular intraepithelial neoplasia, high gradeCarcinoma and Other8150Islet cell carcinoma Neuroendocrine8151Insulinoma, malignant Neuroendocrine8152Glucagonoma, malignant Neuroendocrine8153Gastrinoma, malignantNeuroendocrine8154Mixed islet cell and exocrine adenocarcinoma? Neuroendocrine8155VipomaNeuroendocrine8156Somatostatinoma, malignantNeuroendocrine8160Cholangiocarcinoma Carcinoma and Other8162Klatskin tumorCarcinoma and Other8163Pancreatobiliary-type carcinomaCarcinoma and Other8170Hepatocellular carcinoma, NOSCarcinoma and Other8171Hepatocellular carcinoma, fibrolamellar Carcinoma and Other8180Combined hepatocellular carcinoma and cholangiocarcinomaCarcinoma and Other8190Trabecular adenocarcinomaCarcinoma and Other8200Adenoid cystic carcinomaCarcinoma and Other8201Cribriform carcinomaCarcinoma and Other8210Adenocarcinoma in adenomatous polypCarcinoma and Other8211Tubular adenocarcinomaCarcinoma and Other8230Solid carcinoma NOSCarcinoma and Other8231Carcinoma simplexCarcinoma and Other8240Carcinoid tumour NOS Neuroendocrine8241Enterochromaffin cell carcinoidNeuroendocrine8243Goblet cell carcinoid Neuroendocrine8244Composite carcinoidNeuroendocrine8245Adenocarcinoid tumourCarcinoma and Other8246Neuroendocrine carcinomaNeuroendocrine8248ApudomaNeuroendocrine8249Atypical carcinoid tumorNeuroendocrine8251Alveolar adenocarcinoma Carcinoma and Other8253Bronchio-alveolar carcinoma, mucinousCarcinoma and Other8255Adenocarcinoma with mixed subtypesCarcinoma and Other8260Papillary adenocarcinoma NOSCarcinoma and Other8261Adenocarcinoma in villous adenomaCarcinoma and Other8262Villous adenocarcinomaCarcinoma and Other8263Adenocarcinoma in tubulovillous adenomaCarcinoma and Other8265Micropapillary carcinomaCarcinoma and Other8290Oxyphilic adenocarcinomaCarcinoma and Other8310Clear cell adenocarcinoma NOSCarcinoma and Other8312Renal cell carcinoma, NOSCarcinoma and Other8323Mixed cell adenocarcinomaCarcinoma and Other8340Papillary carcinoma, follicular variantCarcinoma and Other8341Papillary microcarcinomaCarcinoma and Other8360Multiple endocrine adenomasNeuroendocrine8380Endometrioid adenocarcinoma, NOSCarcinoma and Other8401Apocrine adenomaCarcinoma and Other8408Eccrine papillary adenocarcinomaCarcinoma and Other8430Mucoepidermoid carcinomaCarcinoma and Other8440Cystadenocarcinoma NOSCarcinoma and Other8441Serous cystadenocarcinoma NOS Carcinoma and Other8450Papillary cystadenocarcinoma NOS Carcinoma and Other8452Solid pseudopapillary carcinomaCarcinoma and Other8453Intraductal papillary-mucinous carcinoma, invasiveCarcinoma and Other8460Papillary serous cystadenocarcinomaCarcinoma and Other8470Mucinous cystadenocarcinoma NOS Carcinoma and Other8471Papillary mucinous cystadenocarcinoma Carcinoma and Other8472Mucinous cystic tumor of borderline malignancyCarcinoma and Other8473Papillary mucinous cystadenoma, borderline malignancyCarcinoma and Other8480Mucinous adenocarcinomaCarcinoma and Other8481Mucin-producing adenocarcinomaCarcinoma and Other8490Signet ring cell carcinomaCarcinoma and Other8500Infiltrating duct carcinoma Carcinoma and Other8503Intraductal papillary adenocarcinoma with invasion? Carcinoma and Other8504Intracystic carcinoma, NOSCarcinoma and Other8508Cystic hypersecretory carcinomaCarcinoma and Other8510Medullary carcinoma NOSCarcinoma and Other8520Lobular carcinoma, NOSCarcinoma and Other8521Infiltrating ductular carcinoma Carcinoma and Other8522Infiltrating duct and lobular carcinomaCarcinoma and Other8523Infiltrating duct mixed with other types of carcinomaCarcinoma and Other8550Acinar cell carcinomaCarcinoma and Other8551Acinar cell cystadenocarcinomaCarcinoma and Other8552Mixed acinar-ductal carcinomaCarcinoma and Other8560Adenosquamous carcinomaCarcinoma and Other8570Adenocarcinoma with squamous metaplasiaCarcinoma and Other8571Adenocarcinoma with cartilaginous and osseous metaplasiaCarcinoma and Other8572Adenocarcinoma with spindle cell metaplasiaCarcinoma and Other8573Adenocarcinoma with apocrine metaplasiaCarcinoma and Other8574Adenocarcinoma with neuroendocrine differentiationNeuroendocrine8575Metaplastic carcinoma, NOSCarcinoma and Other8576Hepatoid adenocarcinomaCarcinoma and Other8680Paraganglioma, malignantCarcinoma and Other8693Extra-adrenal paraganglioma, malignantCarcinoma and Other8720Malignant melanoma NOSCarcinoma and Other8743Superficial spreading melanomaCarcinoma and Other8800Sarcoma NOSCarcinoma and Other8801Spindle cell sarcomaCarcinoma and Other8802Giant cell sarcoma Carcinoma and Other8803Small cell sarcomaCarcinoma and Other8804Epithelioid sarcomaCarcinoma and Other8806Desmoplastic small round cell tumorCarcinoma and Other8810Fibrosarcoma NOSCarcinoma and Other8815Solitary fibrous tumor, malignantCarcinoma and Other8830Fibrous histiocytoma, malignantCarcinoma and Other8850Liposarcoma NOSCarcinoma and Other8851Liposarcoma, well differentiatedCarcinoma and Other8852Myxoid liposarcomaCarcinoma and Other8858Dedifferentiated liposarcomaCarcinoma and Other8890Leiomyosarcoma NOSCarcinoma and Other8891Epithelioid leiomyosarcomaCarcinoma and Other8900Rhabdomyosarcoma NOSCarcinoma and Other8901Pleomorphic rhabdomyosarcoma, adult typeCarcinoma and Other8920Alveolar rhabdomyosarcomaCarcinoma and Other8930Endometrial stromal nodule (C54.1)Carcinoma and Other8933AdenosarcomaCarcinoma and Other8936Gastrointestinal stromal sarcomaCarcinoma and Other8940Mixed tumour, malignant NOSCarcinoma and Other8971Pancreatoblastoma Carcinoma and Other8980Carcinosarcoma NOSCarcinoma and Other8982Malignant myoepitheliomaCarcinoma and Other8990Mesenchymoma, malignantCarcinoma and Other9041Synovial sarcoma, spindle cellCarcinoma and Other9050Mesothelioma, malignantCarcinoma and Other9064GerminomaCarcinoma and Other9070Embryonal carcinoma NOSCarcinoma and Other9080Teratoma, malignant NOSCarcinoma and Other9081TeratocarcinomaCarcinoma and Other9120HaemangiosarcomaCarcinoma and Other9130Haemangioendothelioma, malignantCarcinoma and Other9133Epithelioid hemangioendothelioma, malignantCarcinoma and Other9250Giant cell tumor of bone, malignantCarcinoma and Other9251Giant cell tumor of soft parts, NOSCarcinoma and Other9363Melanotic neuroectodermal tumorCarcinoma and Other9364Peripheral neuroectodermal tumourCarcinoma and Other9370Chordoma, NOSCarcinoma and Other9473Primitive neuroectodermal tumor, NOSCarcinoma and Other9540Malignant peripheral nerve sheath tumorCarcinoma and Other9560Neurilemoma, malignantCarcinoma and Other9999CONCORD-3 value for unknown morphologyCarcinoma and Other ................
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