ATYPICAL PARKINSONIAN DISORDERS - Parkinson’s Disease ...
ATYPICAL PARKINSONIAN
DISORDERS
Eugene C. Lai, M.D., Ph.D.
Michael E. DeBakey VA Medical Center Baylor College of Medicine
PARKINSONISM
akinetic-rigid syndrome
PARKINSONISM
? Symptoms of Parkinson's disease:
akinesia, bradykinesia, rigidity, postural instability, gait impairment, tremor
? A common, age-related syndrome
ATYPICAL PARKINSONISM
? Parkinson Plus Syndromes ? Secondary Parkinsonism ? Early falling, early dementia, early
autonomic dysfunction
PARKINSON'S DISEASE
General Considerations
? The second most common progressive
neurodegenerative disorder
? The most common neurodegenerative movement
disorder
? It is a complex disease with variable symptoms ? Symptoms and neuropathology are well
characterized
? Pathogenesis of PD is not clear ? May be multifactorial and heterogeneous in etiology ? Misdiagnosis rate of PD is about 10-25%
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