Supplementary Material



Supplementary MaterialAll cause mortalityFigure 1a ELF test performance in predicting Figure 1b Biopsy performance in predictingall cause mortality all cause mortalityFigure 2a ELF test performance in Figure 2b Biopsy performance in predicting liver related outcomes prediction of liver related outcomes (tertiles)Figure 2c ELF test (sextiles) performance in Figure 2d Biopsy performance in prediction predicting liver related outcomes of liver related outcomes (Ishak stages 0-6)ELF test values in the two highest groups with respect to liver related clinical outcomes (Figure 3) 3. Liver related outcomes related to (table 3a) ELF score (table 3b) Biopsy scoreTable 3a ELF groups1234TotalNo Liver related outcome181183293396Liver related outcome320241461Total1842035317457Table 3b Baseline biopsy score (Ishak)0123456TotalNo Liver related outcome104945442361325368Liver related outcome2417662652Total1069855494219514204. ELF test in performance in patients with ALD and those with any other aetiology on prediction of liver related outcomes at 8 yearsFigure 4a ELF test performance in prediction Figure 4b ELF test performance in prediction of liver related clinical outcomes in those patients of liver related clinical outcomes in those with ALD (n=85) patients with aetiology NOT ALD (n=372)5. ELF test performance in prediction of liver related clinical outcomes in those patients with cirrhosis on biopsy (Ishak stages 5,6)Figure 5 Kaplan Meier curve of survival to 8 years from liver related outcomes for ELF in those patients with cirrhosis on biopsy (Ishak 5,6) n=706. Performance of ELF test in those patients who develop liver related clinical outcomes and who DO NOT have cirrhosis on biopsy 20 Patients without cirrhosis on biopsy (Ishak 5,6) have developed clinical outcomes (total clinical outcomes with biopsy =52). The aetiology of these was as below. Of these 20 without cirrhosis on biopsy, n=9 were in top two groups of ELF (ELF score >10.4Table 4 Liver disease aetiology and ELF test for patients with Ishak stages 0-4 on biopsy who have clinical outcomes.01234totalHCV010113ALD1212410HBV000202PBC000011PSC000202AIH010001Cryptogenic100001 ................
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