Pharmacology: Basics for RNs

A selective PDE5 inhibitor must have a 100 fold differential in the IC. 50 for PDE5 v PDE6, at least 1000 fold differential in IC 50 for PDE5 v PDE1c and an IC 50 against PDE5 of less than 10 nM. Moreover, as the claimants emphasise, the priority document states in terms that selective PDE5 inhibitors “vary significantly in chemical structure ... ................
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