Drug - University of Washington



THE NEED-TO-KNOW ANTIMICROBIALS

Yearly update by Rho Chi

Class of 2008

University of Washington School of Pharmacy

Autumn Quarter, 2006

|Generic name |AMOXICILLIN |

|Proprietary name |Amoxil, Polymox |

|Class (generation) |Aminopenicillin |

|MOA (bactericidal/bacteriostatic) |Binds to PBPs to inhibit cell wall synthesis, bactericidal |

|Spectrum (Gm+, Gm-, anaerobes) |Gram +: streptococci, Enterococcus, but NOT S. aureus |

| |Gram - : only a few (E. coli, Proteus spp, a few others)…lots of |

| |resistance |

| |No below-the-diaphragm anaerobic activity |

|DOC for which diseases |AOM, ABS, prophylaxis of endocarditis before dental, esophageal, |

| |and upper respiratory procedures |

|Absorption, distribution, metabolism, excretion |Absorbed well from GI tract; widely distributed in tissues |

| |(especially inflamed tissue); renal excretion |

|PD (time vs. concentration dependent killing) |Time-dependent |

|Side effects (what, how common, monitoring) |Diarrhea--common, call MD if excessive, blood in stool or |

| |abdominal cramping |

|Allergies |Possible anaphylaxis or rash |

|Drug interactions |Not common |

|Dose (renal/hepatic failure, obesity) |AOM: 90mg/kg/day, div BID x 10 days |

| |ABS mild/moderate, w/out recent abx: 1 g TID x 10 days |

| |Endocarditis prophylaxis: 2 g po x 1 hr before appt. |

| |CrCl 10-50 mL/min: Give q8-12h |

| |50-90 same, CrCl 10-50: q6-12h, CrCl ................
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