PBRC Scientific Report 2008-2009 - BASIC RESEARCH

BASIC RESEARCH

SCIENTIFIC REPORT | 2008¨C2009

PENNINGTON BIOMEDICAL RESEARCH CENTER

CLINICAL RESEARCH

POPULATION SCIENCE

LOUISIANA STATE UNIVERSIT Y SYSTEM

The Pennington Biomedical Research Center is a campus of the

Louisiana State University System and conducts basic, clinical

and population research. The research enterprise at the Center

includes 80 faculty and more than 40 post-doctoral fellows

who comprise a network of 53 laboratories supported by

lab technicians, nurses, dieticians, and support personnel, and

19 highly specialized core service facilities. The Center's nearly

600 employees occupy several buildings on the 234-acre campus.

Table of Contents

Foreword¡­ ¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­ 3

Vision 2010 ¨C our 5-year strategic plan¡­ ¡­¡­¡­¡­¡­10

Centers of Excellence¡­ ¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­14

Center for Research on Botanicals and

Metabolic Syndrome¡­ ¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­

National Obesity Research Center¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­

Center of Biomedical Research Excellence (COBRE)¡­ ¡­¡­

Institute for Dementia Research and Prevention (IDRP)¡­¡­

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Basic Research¡­ ¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­19

Basic Research Laboratories ¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­

DNA Damage and Repair¡­ ¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­

The William Hansel Cancer Prevention Laboratory¡­¡­¡­¡­

Antioxidant and Gene Regulation¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­

Molecular Endocrinology¡­ ¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­

Oxidative Stress and Disease¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­

John S. McIlhenny Botanical Research Laboratory¡­ ¡­¡­¡­

Mechanisms of Diabetes Complications¡­ ¡­¡­¡­¡­¡­¡­¡­

Epigenetics and Obesity¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­

Functional Genomics ¡­ ¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­

Gene-Nutrient Interactions ¡­ ¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­

Human Genomics¡­ ¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­

Molecular Genetics and Thermogenesis¡­ ¡­¡­¡­¡­¡­¡­¡­

Regulation of Gene Expression¡­ ¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­

Taste Genetics¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­

Nutrition and Neural Signaling¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­

Autonomic Neuroscience¡­ ¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­

Leptin Signaling in the Brain¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­

Neurobehavior¡­ ¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­

Neurobiology and Nutrition I¡­ ¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­

Neurobiology and Nutrition II¡­ ¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­

Neurosignaling ¡­ ¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­

Aging and Neurodegeneration¡­ ¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­

Blood Brain Barrier I¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­

Blood Brain Barrier II¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­

Inflammation and Neurodegeneration¡­¡­¡­¡­¡­¡­¡­¡­¡­

Neurotrauma and Nutrition¡­ ¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­

LOUISIANA STATE UNIVERSITY SYSTEM

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Clinical Research¡­ ¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­61

Clinical Research Laboratories¡­ ¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­

John W. McIlhenny Skeletal Muscle Physiology ¡­ ¡­¡­¡­¡­

Behavioral Medicine¡­ ¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­

Behavior Modification Clinical Trials ¡­ ¡­¡­¡­¡­¡­¡­¡­¡­

Ingestive Behavior¡­ ¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­

Pharmacology-based Clinical Trials¡­ ¡­¡­¡­¡­¡­¡­¡­¡­¡­

Women¡¯s Health, Eating Behavior, and Smoking

Cessation Programs¡­ ¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­

Exercise Biology¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­

Inactivitiy Physiology ¡­ ¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­

Preventive Medicine¡­ ¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­

Human Physiology ¡­ ¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­

CLINICAL RESEARCH UNITS

Message from the Executive Director¡­¡­¡­¡­¡­¡­¡­ 4

Nutritional Neuroscience and Aging¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­

Nutrient Sensing and Adipocyte Signaling¡­ ¡­¡­¡­¡­¡­¡­

Neuroendocrine Immunology¡­ ¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­

Protein Structural Biology¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­

Dietary Obesity¡­ ¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­

Infection and Obesity¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­

Developmental Biology¡­ ¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­

Epigenetics and Nuclear Reprogramming¡­¡­¡­¡­¡­¡­¡­¡­

Protein Deficiency and Developmental Biology¡­ ¡­¡­¡­¡­

Regenerative Biology¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­

Stem Cell Biology¡­ ¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­

Ubiquitin Biology¡­ ¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­

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Population Science¡­ ¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­75

Population Science Laboratories¡­ ¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­

Chronic Disease Epidemiology¡­ ¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­

Contextual Risk Factors¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­

Health Behaviors and Chronic Disease¡­¡­¡­¡­¡­¡­¡­¡­¡­

Health Economics¡­ ¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­

Nutritional Epidemiology¡­ ¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­

Physical Activity Epidemiology¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­

Health Psychology¡­ ¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­

Physical Activity and Ethnic Minority Health¡­ ¡­¡­¡­¡­¡­

Walking Behavior¡­ ¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­

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Division of Education¡­ ¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­87

SCIENTIFIC REPORT | 2008¨C2009

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Table of Contents

Core Services¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­89

Basic Science¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­ 89

Animal Metabolism and Behavior ¡­ ¡­¡­¡­¡­¡­¡­¡­ 90

Cell Biology and Cell Imaging ¡­ ¡­¡­¡­¡­¡­¡­¡­¡­¡­ 90

Cell Culture ¡­ ¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­ 91

Comparative Biology ¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­ 91

Genomics ¡­ ¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­ 92

Proteomics and Metabolomics¡­ ¡­¡­¡­¡­¡­¡­¡­¡­¡­ 92

Transgenics Core¡­ ¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­ 93

Clinical Research¡­ ¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­ 95

Clinical Chemistry ¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­ 96

Dietary Assessment ¡­ ¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­ 96

Exercise Testing ¡­ ¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­ 97

Imaging / MRS ¡­ ¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­ 97

In-patient Clinic Unit ¡­ ¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­ 98

Library and Information Center ¡­ ¡­¡­¡­¡­¡­¡­¡­¡­ 98

Mass Spectrometry ¡­ ¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­ 99

Metabolic Chambers ¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­ 99

Outpatient Clinic ¡­ ¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­ 100

Recruitment ¡­ ¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­ 100

Research Kitchen ¡­ ¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­ 101

Population Sciences¡­ ¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­ 101

Biostatistics and Data Management ¡­¡­¡­¡­¡­¡­¡­¡­ 101

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SCIENTIFIC REPORT | 2008¨C2009

Administrative Services and Finance¡­¡­¡­¡­¡­¡­ 103

Communications ¡­ ¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­

Computing Services ¡­ ¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­

Facilities Management ¡­ ¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­

Fiscal Operations ¡­ ¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­

Sponsored Projects ¡­ ¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­

Intellectual Property, Legal and Regulatory Affairs ¡­¡­¡­¡­¡­¡­

Human Resource Management¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­

Pennington Stores¡­ ¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­

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Adjunct Faculty ¡­ ¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­ 109

Doctorate Honoris Causa¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­ 111

List of 2008-2009 Publications¡­ ¡­¡­¡­¡­¡­¡­¡­ 113

Peer Reviewed Journal Articles ¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­ 113

Books and Chapters ¡­ ¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­ 133

Our Supporters¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­ 137

Pennington Medical Foundation Trust¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­ 137

Pennington Biomedical Research Foundation ¡­¡­¡­¡­¡­¡­¡­¡­ 139

Our Donors 2008 & 2009¡­ ¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­¡­ 142

PENNINGTON BIOMEDICAL RESEARCH CENTER

Foreword

During the years 2008 and 2009, the span of time covered

by this issue of the Scientific Report, we have achieved some

significant milestones, including expansion of our clinical

facilities, launching the first statewide discussion of children¡¯s

obesity, and embarking on new and exciting research in dementia

to name but a few.

We are grateful to the Louisiana State University System

Board of Supervisors, the Louisiana Board of Regents, and the

Commissioner of Higher Education, Dr. Joseph Savoie and later

Dr. Sally Clausen, for the support they have given to our efforts.

We are especially grateful for the support given by LSU System

Board Chairman, James Roy and subsequently R. Blake Chatelain,

and System President, Dr. John Lombardi.

In recent times, we have benefitted from the support of

our city¡¯s business and political leaders. I would like to thank

Louisiana Governor Bobby Jindal, Secretary of the Louisiana

Department of Economic Development, Stephen Moret, and

President and CEO of the Baton Rouge Area Chamber, Adam

Knapp. The State, the Department and the Chamber placed

the Center¡¯s legislative funding at the top of their priority list.

Baton Rouge Mayor, Melvin ¡°Kip¡± Holden, has also taken a

keen personal and professional interest in the Center, and we

are grateful for his commitment. We also want to express our

thanks to John Davies and John Spain of the Baton Rouge Area

Foundation for their support over the years.

Our deepest gratitude goes to the men and women who serve

on the boards of our two supporting foundations: the Pennington

Medical Foundation and the Pennington Biomedical Research

Foundation. Mrs. Paula Pennington de la Bretonne, chair of

the Pennington Medical Foundation, leads a group of dedicated

individuals who have made it possible for the Pennington

Biomedical Research Center to break ground on new facilities and

to acquire sophisticated equipment and technologies on a regular

basis. Likewise, John Noland and now Tim Barfield, Chairman

of the Board, and Ms. Jennifer Winstead, President and CEO

of the Pennington Biomedical Research Foundation, and their

fellow board members are fully engaged in the task of creating

endowed chairs and professorships and raising unrestricted funds

as well. We are all extremely grateful for their dedication and

hard work on our behalf. To all the donors who are so generous

in their response to the requests from the Pennington Biomedical

Research Foundation, our heartfelt gratitude and thanks.

The progress we have made during these past two decades

years would not have been possible without the dedication of

our faculty, staff and management team. Their devotion to our

research and education efforts makes the Pennington Biomedical

Research Center an inspiring place to work.

Our mission remains: to promote healthier lives through research

and education in nutrition and preventive medicine. What has

continued to develop is the breadth and depth of our science and

our ability to achieve our mission. In this report, you will discover

a wide spectrum of research programs and projects. You will also

get a brief introduction to the process leading to new discoveries.

To learn more about our science and our Center, please visit

pbrc.edu. If you would like to learn more about supporting

our mission, please visit the website of the Pennington Biomedical

Research Foundation at: .

Claude Bouchard, Ph.D.

Executive Director

LOUISIANA STATE UNIVERSITY SYSTEM

SCIENTIFIC REPORT | 2008¨C2009

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