COVID-19 in pregnant people; COVID-19 vaccine safety in pregnant people ...

COVID-19 in pregnant people and infants ages 0-5 months

Sascha Ellington, PhD, MSPH, CPH Emergency Preparedness and Response Team Lead Division of Reproductive Health National Center for Chronic Disease Prevention and Health Promotion Centers for Disease Control and Prevention

coronavirus

COVID-19 in Pregnant People

COVID-19 in Pregnant People

Assessing risk of COVID-19 in pregnancy 1. Is pregnancy a risk factor for severe illness?

2. Is COVID-19 associated with increased risks for maternal complications and adverse pregnancy outcomes ?

3. Are infants born to people with COVID-19 during pregnancy at risk for adverse outcomes?

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Living Systematic Review and Meta-Analysis: Assessing pregnancy as a risk factor for severe illness

Outcomes

# Studies

# with event/# in group (%)

Pregnant with covid-19

Non-pregnant with COVID-19

Odds ratio (95% CI)

All cause mortality

11

ICU admission

10

Invasive ventilation

8

242/122222 (0.2) 912/118403 (0.8) 310/116458 (0.3)

5252/2138726 (0.2) 11513/1908957 (0.6) 3607/1772716 (0.2)

1.48 (0.62 to 3.49) 2.61 (1.84 to 3.71) 2.41 (2.13 to 2.71)

ECMO

5

19/30694 (0.1)

122/432623 (0.0)

3.71 (0.71 to 19.41)

ARDS

4

22/197 (11.2)

45/418 (10.8)

1.19 (0.24 to 5.95)

Major organ failure

4

5/197 (2.5)

ECMO: extracorporeal membrane oxygenation; ARDS: Acute respiratory distress syndrome

28/418 (6.7)

0.39 (0.15 to 1.04)

Allotey, J et al. Clinical manifestations, risk factors, and maternal and perinatal outcomes of coronavirus disease 2019 in pregnancy: living systematic review and meta-analysis. BMJ. 2020. Updated 7-May 2022

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Reported COVID-19 cases, ICU admission, and deaths among pregnant people

(National COVID-19 Case Surveillance Data; Jan 22, 2020?Jul 31, 2022)

25000

Total: 226,263 cases 738 ICU Admissions

20000

329 Deaths

70

ICU admission

Deaths

60

Pregnant people infected

50

15000 40

Total laboratory-confirmed cases Total ICU admissions or deaths

30 10000

20

5000 10

0

0

5

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