PHS 398 (Rev. 9/04), Biographical Sketch Format Page



|BIOGRAPHICAL SKETCH |

|Provide the following information for the key personnel and other significant contributors. |

|Follow this format for each person. DO NOT EXCEED FOUR PAGES. |

| |

|NAME |POSITION TITLE |

|Jody L. Tanabe |Professor |

|eRA COMMONS USER NAME | |

|TANABE, J | |

|EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) |

|INSTITUTION AND LOCATION |DEGREE |YEAR(s) |FIELD OF STUDY |

| |(if applicable) | | |

|University of California, Davis |B.S. |1981 |Physiology |

|University of California, San Diego |M.D. |1985 |Medicine |

|San Francisco VA Medical Ctr., SF, California |Post-Doc |1997 |MR Spectroscopy |

| | | | |

| | | | |

A. Personal statement

I am a Professor of Radiology, Chief of Neuroradiology, and Vice-Chair of Research for the Department of Radiology. In addition to my clinical, educational, and administrative responsibilities, my research interests involve studying neural correlates of drug, alcohol, and nicotine use. I have extensive experience using anatomic and functional MRI methods to investigate neural mechanisms of behavior in substance dependence.

B. Positions and Honors.

POSITIONS

1985-1986 Intern in General Surgery, Albert Einstein College of Medicine, NY

1986-1988 Research assistant, Cerebral Blood Flow and Metabolism Laboratory, Cornell University, NY

1986-1992 Resident, Radiology, New York Hospital-Cornell Univ. Med. Ctr., NY

1992-1993 Fellowship, Neuroradiology, UCSF Medical Center, San Francisco, CA

1993-1994 Neuroradiologist, Kaiser Permanente Northern California Hospitals

1994-1997 Post-doc fellow, Magnetic Resonance Unit, San Francisco VA Medical Center-UCSF, CA

1997-1999 Assistant Professor of Radiology, NYU Medical Center

1999-2003 Assistant Professor Radiology, University of Colorado Denver SOM

2003-2010 Associate Professor Radiology and Psychiatry, University of Colorado Denver SOM

2010-present Professor of Radiology, Psychiatry, and Neurology, University of Colorado Denver SOM

HONORS

1998-2000 Radiologic Society of North America, Scholar Award

1995-1997 National Research Service Award, NIH (National Institutes of Drug Abuse)

2002, 2006 Faculty Research Award, UC School of Medicine, Department of Radiology

2009 Univ. Colorado SOM Women in Medicine & Science, Professional Development Award

2012 Colorado CTSI Leadership for Innovative Team Science, Class 2012-2013, UC Denver

2013 Member of College for Problems on Drug Dependence

2014 Senior Editor, American Journal of Neuroradiology

2014 Distinguished Investigators of the Academy of Radiology Research Award, RSNA

2013-2017 NIH Regular study section member, Neural basis of psychopathology, addictions, and sleep disorder (NPAS)

C. Selected peer-reviewed publications

Relevant publications

1. Tanabe, J, Thompson, L, Claus, E, Dalwani, M, Hutchison, K, Banich, M.T. Prefrontal cortex activity is reduced in gambling and non-gambling substance users during decision-making. Hum Brain Map 2007. 28:1276-1286.

2. Filbey, F.M., Claus, E., Audette, A., Niculescu, M., Banich, MT, Tanabe, J, Du, YP, Hutchison, KE. Activation of the mesocorticolimbic pathway in response to gustatory alcohol cues. Neuropsychopharm. 2008 33:1391-401. Epub 2007 Jul 25

3. Tanabe, J., Dalwani, M, Thompson, L, Tregellas, J, Owens, E., Crowley, T., and Banich, M.T. Medial orbitofrontal gray matter is reduced in abstinent substance dependent individuals. Biol Psych 2009 65:160-4. Epub 2008 Sep18

4. Dalwani, M., Sakai, J.T., Mikulich-Gilbertson, S., Tanabe, J., Raymond K., Stover S., Thompson, L., Banich, M., Crowley, T. Reduced Cortical Gray Matter Volume In Male Adolescents With Substance And Conduct Problems Drug Alc Dep 2011 118(2-3):295-305. Epub ahead of print PMID:21592680, PMC3170449

5. Thompson L, Claus E, Mikulich-Gilbertson S, Banich M, Crowley T, Krmpotich T, and Tanabe J. Negative reinforcement learning is affected in substance dependence Drug Alc Dep Epub ahead of print 2011 Nov 10 PMID:22079143; PMCID: PMC3292654

6. Tanabe J, York P, Krmpotich T, Miller D, Dalwani M, Sakai J, Mikulich-Gilbertsom S., Thompson L, Banich M., Rojas D. Frontal and insular cortical thickness in substance dependent individuals 2012 Nov 15. Epub ahead of print, AJNR Am J Neuroradiol. PMID: 23153869

7. Krmpotich TD, Tregellas JR, Thompson LL, Banich MT, Klenk AM, Tanabe J. Resting state activity in the left executive control network is associated with behavioral approach and is increased in substance dependence. Drug Alc Dep 2013;129(1-2):1-7. PMID: 23428318, PMCID: PMC3618865

8. Tanabe J, Reynolds J, Krmpotich K, Claus E, Thompson L, Du Y, Banich M. Reduced neural tracking of prediction error in substance dependent individuals. Am J Psychiatry. 2013 1;170(11):1356-63. PMID: 23897123

9. Perry R, Krmpotich T, Thompson L, Mikulich-Gilbertson S, Banich MT, Tanabe J. Personality traits in substance dependence may be modulated by sex. Drug Alc Dep 2013 Nov 1;133(1):222-7. PMID: 23725607

10. Yamamoto D, Reynolds J, Krmpotich T, Banich MT, Thompson L, Tanabe J. Temporal profile of frontal-limbic activity in substance dependence. Drug Alc Dep 2014 Mar 1;136:108-14.

11. Krmpotich TD, Thompson LL, Mikulich-Gilbertson S, Perry R, Banich MT, Tanabe J. Substance users with pathological gambling show higher impulsivity and worse decision-making than substance users without pathological gambling. Accepted for publication J Addict Med. March 2015

12. Yamamoto DY, Woo C, Wager TD, Regner M, Tanabe, J. Influence of dorsolateral prefrontal lobe and ventral striatum on risk avoidance in addiction: A Mediation Analysis. Drug Alcohol Depend. 2015 February 16 [Epub ahead of print]

Additional publications of importance to the field

13. Tanabe, J., Miller, D., Tregellas J., Freedman R., Meyer F. Comparison of detrending methods for optimal fMRI pre-processing. Neuroimage 2002 15:902-907

14. Tanabe, J, Tregellas J, Miller D, Ross R, Freedman, R. Brain activation and habituation during fMRI of smooth pursuit eye movements Neuroimage 2002 17:1315-1324.

15. Tanabe, J, Crowley, T, Hutchison, K, Miller, D, Johnson, G, Du, Y.P., Zerbe, G., Freedman, R. Ventral striatal blood flow is altered by acute nicotine but not withdrawal from nicotine. Neuropsychopharm, 2008 33:627-633.

16. Wylie K, Martin L, Wogammit N, Tanabe J, Tregellas J. Nicotine Increases Cerebellar Activity During Finger Tapping. PLOS One 2013;8(12):e84581. PMID: 24358367

17. Tanabe, J., Nyberg E, Martin L, Martin J, Cordes D, Kronberg E, Tregellas J. Nicotine Suppresses the Default Mode Network in Resting State. Psychopharm 2011 Jul;216(2):287-95, Epub ahead of print. PMID:21331518

18. Wylie K, Rojas D, Tanabe J, Martin L, Tregellas JR. Nicotine and networks. Neuroimage 2012 Vol. 63, 15 Oct: 73-80. PMID: 22796985; PMCID: PMC3429645

19. Rangaswamy, M, Porjesz, B., Babak A., Choi, SJ, Tanabe, J, Lim, KO, Begleiter, H. A functional MRI study of visual oddball: Evidence for frontoparietal dysfunction in subjects at risk for alcoholism Neuroimage 2004 21:329-339

20. Tregellas, J.R., Tanabe, J., Rojas, D., Shatti, S., Olincy, A., Johnson, L., Martin, L., Soti, F., Kem, W.R., Leonard, S., and Freedman, R. Effects of a Nicotinic Agonist on Default network activity in Schizophrenia. Biol Psych 2011 Jan 1; 69 (1):7-11. Epub 2010 Aug 21. PMID: 20728875

21. Tregellas, J, Tanabe J, Martin L, Freedman, R. fMRI of Response to Nicotine During a Smooth Pursuit Eye Movement Task in Schizophrenia Am J Psych 2005; 162:391-393

22. Tanabe, J, Tregellas, J., Martin, L, Freedman, R. Effects of nicotine on hippocampal and cingulate activity during smooth pursuit eye movement in schizophrenia Biol. Psych.2006 59:754-761

23. Tregellas, J., Shatti, S., Tanabe, J., Martin, L., Gibson, L., Wylie, K., Freedman, R., Rojas, D. Gray Matter Volume Differences and the Effects of Smoking on Gray Matter in Schizophrenia. Schiz Res 2007 97:242-9

C. Research Support

R01 DA027748-01 (Tanabe PI) 09/01/09 – 05/31/15 (NCE)

NIH/NIDA

Neural Correlates of Avoidance Learning in Substance Abuse

This project will investigate the neural correlates of negative reinforcement learning and its relationship to negative affective states in substance dependence.

1 R01 DA031761-01A1 (Sakai, PI) 04/01/12-03/31/16

NIH/NIDA

Adolescents with substance and conduct problems: Imaging callous-unemotionality.

Role: Co-investigator

R25 DA 033219-03 Hopfer (PI) 04/01/12-03/31/17

NIDA

Substance use disorder research training for medical students

This award supports recruitment and training of medical students for careers as leaders in substance use research. Role: Preceptor

COMPLETED:

R21 DA 024104-01A1 (Tanabe PI) 06/15/08-05/31/11

NIH/NIDA

This project uses a computational model of decision-making to test hypotheses about the role of fronto-striatal networks in the processing of magnitude compared to frequency information in substance dependent individuals.

P50 MH079485-01A1 (Banich PI) 09/01/07–08/31/12

NIH/NIMH “Interdisciplinary Behavioral Science Center: Determinants of Executive Function and Dysfunction”. This center grant uses behavioral, neuroimaging, and computational methods to examine executive function. Role: Investigator

2 R01 DA009842-11A1 (Crowley PI) 09/05/06-04/30/11 NIH/NIDA

Substance Dependent Adolescents: Imaging Risk-Taking

This project uses fMRI to examine the neural substrates of decision making in substance dependent adolescents. Role: Co-I

K08 DA015051-01A1 (Tanabe PI) 09/01/03-07/31/08

NIH/NIDA

Neuroimaging of Nicotine Withdrawal

The goal of this of career development award is to provide me with the skills to become an expert in neuroimaging of substance abuse, specifically the effects of nicotine on the brain. The research involved determining if nicotine withdrawal is associated with changes in cerebral blood flow in mesolimbic brain regions.

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