CURRICULUM VITAE



CURRICULUM VITAENAME: Fabio FusiDATE AND PLACE OF BIRTH: December 25th, 1963, Siena, Italy.ADDRESS: Via E.S. Piccolomini, 63 - 53100 SIENA - ITALY.Phone (home): +39-0577-236469(office): +39-0577-235203(lab): +39-0577-235377/5378e-mail: fabio.fusi@unisi.itMARITAL STATUS: Married - High School Diploma (Liceo Scientifico, Siena, Italy).1991 - Degree in Pharmaceutical Chemistry and Technology (Pharmacy), University of Siena, Italy, 110/110 cum laude, with experimental thesis: "Antioxidant phenol derivatives: calcium antagonistic properties and interaction with mitochondrial oxidative phosphorylation".1995 - Ph.D. in Pharmaceutical Sciences, with a Scholarship from the Italian Ministry of the University and the Scientific Research (MURST), in the Institute of Pharmacological Sciences, University of Siena, Italy.English: written, read (7 years).RESEARCH EXPERIENCE:1989-present - Institute of Pharmacological Sciences, Department of Biomedical Sciences, Department of Neurosciences, Department of Life Sciences, Department of Biotechnologies, Chemistry and Pharmacy, University of Siena, Italy. Experimental research on novel natural as well synthetic modulators of ionic currents in smooth muscle cells (patch-clamp technique), in vitro antioxidant properties of phenol derivatives, cyclooxygenase activity of hemoglobin and peroxidases, interaction of taurine and related compounds with mitochondrial oxidative phosphorylation.FELLOWSHIPS ABROAD:Oct./Dec. 1989 - Department of Biochemistry, Trinity College, Dublin, Ireland. Dr. T. Mantle's laboratory. Studies on biochemical enzymology. ERASMUS Fellowship (ICP-89-I-0062, EU).Nov. 1990/Jan. 1991 - Department of Biochemistry, Trinity College, Dublin, Ireland. Dr. M.P. Murphy's laboratory. Studies of the interaction of antioxidant phenol derivatives with mitochondrial oxidative phosphorylation. ERASMUS Fellowship (ICP-90-I-0072/12, EU).Feb./Apr. 1993 - Institute of Physiology, Bulgarian Academy of Sciences, Sofia, Bulgaria. Prof. K.K. Boev's laboratory. Studies on the interaction of some antioxidant phenol derivatives with smooth muscle cells. TEMPUS Fellowship (JEP-0789-92/93 EU).Nov. 1993/May 1994 - Research Associate at the Department of Pharmacology, School of Medicine, Southern Illinois University, Springfield, IL, USA. Prof. E. Giacobini's laboratory. Studies on CNS concerning the development of new drugs for the treatment of patients affected by Alzheimer's disease.Mar./Sep. 1995 - Research Associate at the Department of Pharmacology, University of Cambridge, U.K. Dr. B.A. Callingham's laboratory. Studies on semicarbazide-sensitive amino oxidases in deer digital artery and mesanglial cell; studies on adenosine receptors in guinea pig aorta.FELLOWSHIPS IN ITALY:May/Oct. 1991 - Convention with the Department of historical-social and philosophic studies, University of Siena, Italy.Feb./Mar. 1995 - Research Associate in the Institute of Pharmacological Sciences, University of Siena, Italy.Nov. 1995 - Contract at the Institute of Pharmacological Sciences, University of Siena, Italy.Jan./Mar. 1996 - Research Associate at the Institute of Pharmacological Sciences, University of Siena, Italy. Project BIOMED I (Eurotaurine: regulation and function of taurine in the mammalian central nervous system. BMH1-CT94-1402).Apr. 1996/Mar. 1998 - Research Fellowship from the University of Siena.Aug 1997/Gen. 1999 - Technical assistant in the Institute of Pharmacological Sciences, University of Siena, Italy, under the joint project Italy-Bulgaria entitled “Chemical and physiopathological relationships in cerebral ischaemia: development of new therapeutic strategies”.Feb. 1999 - Oct. 2002 "Assegno di Ricerca per l'Area Scientifica Farmacologica" (D.R. n. 449 del 21-7-1998) in the Institute of Pharmacological Sciences, University of Siena, Italy.Feb. 2001 - Department of Neuroscience, Physiology Section, University of Turin, Italy. Prof. E. Carbone's laboratory. Studies on Ca2+ currents (single channel) with the patch-clamp technique in smooth muscle as well as neuroendocrine cells.Nov. 2002 – Researcher at the University of Siena, Italy.HONOURS:Dic. 1996 - Fellow of the Italian Pharmacological Society.Nov. 1997 - Qualified as Technical assistant - VII qualification (D.R. n.362, 29.4.1997 - G.U. n.39 (4° serie speciale) 20.5.1997).Nov. 2004 - Dec. 2012 Jan. 2019 - present – Member of Comitato per la Didattica del Corso di Laurea in Chimica e Tecnologia Farmaceutiche, LM e LS.Referee for Biochemical Pharmacology, Journal of Pharmacological Sciences, Pharmacological Research, Pharmacology, Journal of Pharmacy and Pharmacology, Life Sciences, Phytotherapy Research, Journal of Ethnopharmacology, Planta Medica, Journal of Medicinal Food, Molecules, British Journal of Medicine and Medical Research, Journal of Visualized Experiments, Pharmacology Research & Perspectives, Frontiers in Physiology, British Journal of Pharmacology.Jun. 2015/Feb. 2017 – Member of the Pharmacology Research & Perspectives Editorial Board (Wiley).SCIENTIFIC AND ORGANIZING COMMITTEE OF CONGRESSESSep. 2004 - VIII SEMINARIO NAZIONALE PER DOTTORANDI IN FARMACOLOGIA E SCIENZE AFFINI, Siena, Certosa di Pontignano, September 20-23, 2004.Sep. 2005 - IX SEMINARIO NAZIONALE PER DOTTORANDI IN FARMACOLOGIA E SCIENZE AFFINI, Siena, Certosa di Pontignano September20-23, 2005.Sep. 2006 - X SEMINARIO NAZIONALE PER DOTTORANDI IN FARMACOLOGIA E SCIENZE AFFINI, Siena, Certosa di Pontignano September 25-28, 2006.Sep. 2007 - XI SEMINARIO NAZIONALE PER DOTTORANDI IN FARMACOLOGIA E SCIENZE AFFINI, Siena, Certosa di Pontignano September 24-27, 2007.Sep. 2008 - XII SEMINARIO NAZIONALE PER DOTTORANDI IN FARMACOLOGIA E SCIENZE AFFINI, Siena, Certosa di Pontignano September 22-25, 2008.. 2009 - XIII SEMINARIO NAZIONALE PER DOTTORANDI IN FARMACOLOGIA E SCIENZE AFFINI, Siena, Certosa di Pontignano June 27-30, 2009.. 2010 - XIV SEMINARIO NAZIONALE PER DOTTORANDI IN FARMACOLOGIA E SCIENZE AFFINI, Siena, Certosa di Pontignano September 20-23, 2010. LECTURES:Jun. 2012 - Pharmacology of the Hyacinthaceae family. At The Hyacinthaceae: Chemistry, Pharmacology, Taxonomy and Ethnobotany. An International, Multidisciplinary Symposium. 14th June - 15th June 2012, University of Surrey, Guildford, United Kingdom.TEACHING:Oct. 1993 - Lecturer at the "Training Course in Biochemical Pharmacology", Certosa di Pontignano, Siena, Italy(COMETT Programme, EU).May 1999 - Lecturer at the "Recent advances in Neurobiology", Istituto di Scienze Farmacologiche, University of Siena, Italy (Programme SOCRATES, European Union).2000/2001: - Module "Farmacologia dei Canali Ionici" (n.° 6 ore) (Course: Farmacologia e Farmacoterapia I; Degree in Pharmacy).2001/2002: - Module "Farmacologia dei Canali Ionici" (n.° 10 ore) (Course: Farmacologia e Farmacoterapia I; Degree in Pharmacy).2001/2002: - Module "Standardizzazione Biologica dei Farmaci" (n.° 10 ore) (Course: Farmacologia e Farmacoterapia I; Degree in Pharmacy).2002/2003: - Statistica applicata alla ricerca biomedica (Course: Esercitazioni di statistica; Degree in Tecniche erboristiche, Farmacia, Controllo di qualità nel settore industriale farmaceutico, Scienza e tecnologia dei prodotti cosmetici).2004: - Lecturer at the Training course “Terapia convenzionale e nuove classi di farmaci nel trattamento dell’ipertensione”, Sala Euclide, Matera, Italy, March 13-14, 2004.2007-2010: - Principi di statistica e interpretazione scientifica dell’analisi statistica (Ph.D. school in Physiology, pharmacology, molecular and cellular toxicology).2018/2019 – Chemioterapia Antitumorale e Nuove Terapie Antitumorali; Terapia del Dolore: Aspetti Farmacologici; Terapia delle Malattie del Sistema Nervoso Centrale: Aspetti Farmacoterapeutici (Scuola di Specializzazione in Farmacia Ospedaliera)2003/present - Saggi e Dosaggi Farmacologici (Corso di Laurea in Chimica e Tecnologia Farmaceutiche);2003/present - Statistica Medica (Master Avanzato di II livello in Scienza e Tecnologia Cosmetiche).SUPERVISION OF UNDERGRADUATED STUDENTSGelli Marco (CTF) 13-10-2005Nicoletti Marco (CTF) 27-02-2007Spannocchi Silvia (CTF) 27-02-2007Galantini Silvia (CTF) 08-11-2007Romillo Lucia Maria (CTF) 18-12-2007Simone Maddalena (CTF) 25-02-2009Maiucci Paola (Farmacia) 02-11-2011Marenghi Beatrice (Farmacia) 02-11-2011Zonghi Nicoletta (Farmacia) 02-11-2011Lenoci Marica (CTF) 07-11-2012Redi Tommaso (Farmacia) 25-09-2013Vona Valentina (CTF) 15-04-2014Morello Dario Giuseppe (Farmacia) 31-10-2014Micol Galli (Scienze Biologiche) 12-12-2014Rocco Anna (CTF) 22-04-2015Sebastiani Marco (CTF) 22-04-2015Rosati Claudia (CTF) 30-10-2015Calianno Ilaria (CTF) 20-04-2016Scirocco Chiara (CTF) 20-04-2016Toscano Marianna (CTF) 21-07-2016Li Bergolis Federica (CTF) 26-10-2016Sandroni Cristina (CTF) 12-12-2016Buscemi Salvatore (CTF) 20-7-2017D’Alessandro Chiara (CTF) 20-7-2017Maione Elena (CTF) 20-7-2017D’Ortona Federica (CTF) 25-10-2017Iacomoni Francesca (CTF) 12-12-2017Versienti Gabriele (CTF) 18-07-2018Panico Giacomo (CTF) 20-2-2019Conti Silvia (CTF) 17-4-2019Farris Melania (CTF) 18-7-2019Tagliafierro Stefano (CTF) 18-7-2019Cantore Anna (CTF) 24-10-2019Caivano Gaia (CTF) 24-10-2019Angileri Marianna (Farmacia) 25-10-2019Spinella Carmelo (CTF) 20-2-2020Tiracorrendo Sara (Farmacia) 20-4-2020Pianigiani Irene (CTF) 22-7-2020SUPERVISION OF Ph.D. STUDENTSJan. 2007 - Dr. Donata Iozzi (Doctor europ?us), Doctorate in physiology, pharmacology, molecular and cellular toxicology, XIX cycle. Title: Analysis of the mechanisms underlying the vasorelaxant action of two natural related flavonoids: quercetin and (+/-)-naringenin.Feb. 2008 - Dr. Caterina Lacava (Doctor europ?us), Doctorate in physiology, pharmacology, molecular and cellular toxicology, XX cycle. Title: Pharmacological profile of 3,5-di-t-butylcatechol in the mammalian skeletal muscle and its use in the diagnosis of malignant hyperthermia.Feb. 2009 - Dr. Antonella Ferrara, Doctorate in physiology, pharmacology, molecular and cellular toxicology, XXI cycle. Title: Effect of de-alcoholated red wine in isolated rat heart: protective action in myocardial ischemia-reperfusion injury.Nov. 2012 - Dr. Paolo Mugnai, Doctorate in physiology, pharmacology, molecular and cellular toxicology, XXV cycle. Title: The flavonoid quercetin stimulates the vascular smooth muscle Cav1.2 current: new insight into its mechanism of action.Dec. 2013 - Dr. Miriam Durante, Doctorate in physiology, pharmacology, molecular and cellular toxicology, XXVI cycle. Title: Traditional Vietnamese medicine: new "scaffolds" for the development of drugs active at vascular level.EXTERNAL EXAMINER/REFEREEDec. 2012 - PhD Thesis entitled “The extractives from Sophora Velutina and Calpurnia Aurea and their biological activity“by Erick Kipkoech Korir, University of KwaZulu-Natal, South Africa.Dec. 2012 - PhD Thesis entitled “Synthesis and biological evaluation of fluorinated derivatives of 2-styrylchromones and 2-thioxo imidazole dicarboxylate esters “ by Mehbb I Khail Momin, University of KwaZulu-Natal, South Africa.Feb. 2014 - PhD Thesis entitled “Phytochemistry and bioactive natural products from Lannea Alata, Lannea Rivae, Lannea Shimperi and Lannea Schweinfurthii (Anacardiaceae)“ by Okoth Akinyi Dorothy, University of KwaZulu-Natal, South Africa.Dec. 2015 - PhD Thesis entitled “Synthesis and biological studies of novel pyranochromene derivatives“ by Sunayna Sachin Pawar, University of KwaZulu-Natal, South Africa.Oct. 2015 - University of Padua PRAT (Progetti di Ricerca di ATeneo).Nov. 2016 - PhD Thesis entitled “Synthesis, characterisation and antidiabetic activity of quinoline derivatives“ by Kaalin Gopaul, University of KwaZulu-Natal, South Africa.Jun. 2018 - PhD Thesis entitled “Synthesis and biological activity of quinoline derivatives“ by Hogantharanni Govender, University of KwaZulu-Natal, South Africa.RESEARCH PROJECT FUNDEDAgency: Italian Ministry of Foreign Affairs - Executive programme of scientific and technological co-operation between Italy and South Africa. Period: 2005-2007. Title: "Investigations of isolates from the Hyacinthaceae family for cardiovascular activity". Principal investigators: Dr. Fabio Fusi, Ph.D., and Prof. Dulcie Mulholland, University of KwaZulu-Natal, South Africa.For the exchange of researchersAgency: Italian Ministry of Foreign Affairs - Significant research projects selected within the frame of the IV Executive programme of scientific and technological co-operation between Italy and Vietnam. Period: 2009-2011. Title: "Discovery of novel cardiovascular active agents from selected Vietnamese medicinal plants ". Principal investigators: Dr. Fabio Fusi e Dr. Nguyen Manh Cuong, Hanoi University of Pharmacy, Vietnam.Year 2010: € 35.000.Year 2011: € 30.000.Agency: Italian Ministry of Foreign Affairs - Significant research projects selected within the frame of the II Executive programme of scientific and technological co-operation between Italy and Slovakia. Period: 2009-2011. Title: "Molecular mechanisms underlying the cardiovascular and neuronal protective effects of a flavonoid-rich diet". Principal investigators: Dr. Fabio Fusi e Dr. Lubica Lacinova, Slovak Academy of Sciences, Institute for Molecular Physiology and Genetics, Slovakia.Contract for research project with Rottapharm S.p.A.. Title: “Effect of Andolast on KCa3.1 currents in RBL-2H3 cells”.Year 2010: € 5.500.Agency: Italian Ministry of Education, University and Research. Fondo per il finanziamento delle attività base di ricerca - legge 232/2016 comma 295 (legge di bilancio 2017) (2264-2017-FF-CONRICMIUR-FFABR2017_001) € 3.000Agency: University of Siena. Piano di sostegno alla ricerca 2019 - fondo “attrezzature” (F -LAB) 2019. € 16.000.COURSES:June 15, 1992 - Mini Course on "Reactive species in vascular injury", Prof. Bruce A. Freeman, Institute "Mario Negri", Milan, Italy.Sept. 5-9, 1994 - XIV Advanced Course in Pharmaceutical Chemistry: i) "Cerebral ischemia: new therapeutical approaches"; ii) "Carbohydrates: glycotecnologies and drug design". University of Urbino, Italy.March 12, 2018 - "II secondo criterio di valutazione in Horizon 2020: IMPATTO", Dr. Matteo Di Rosa (Agenzia APRE). University of Siena, Italy.Ph.D. THESISDerivati fenolici di origine naturale o sintetici con proprietà antiossidanti e calcioantagonistiche come farmaci per la prevenzione dei danni tessutali da ischemia-riperfusioneREVIEWSFusi F., Saponara S., Valoti M., Dragoni S., D’Elia P., Sgaragli T., Alderighi D., Kawase M., Shah A., Motohashi N., Sgaragli G. (2006). Cancer cell permeability-glycoprotein as a target of MDR reverters: possible role of novel dihydropyridine derivatives. Curr. Drug Targets, 7, 949-959.(I.F. 4.274)Fusi F., Spiga O., Trezza A., Sgaragli G., Saponara S. (2017). The surge of flavonoids as novel, fine regulators of cardiovascular Cav channels. Eur. J. Pharmacol., 796, 158-174.(I.F. 2.730)Fusi F., Trezza A., Tramaglino M., Sgaragli G., Saponara S., Spiga O. (2020). The beneficial health effects of flavonoids on the cardiovascular system: focus on K+ channels. Pharmacol. Res., 152, 104625.(I.F. 5.574)PUBLICATIONS1) Fusi F., Valoti M., Sgaragli G.P., Murphy M.P. (1991). The interaction of antioxidants and structurally related compounds with mitochondrial oxidative phosphorylation. Methods Find. Exp. Clin. Pharmacol., 13 (9), 599-603.(I.F. 0.577)2) Fusi F., Sgaragli G.P., Murphy M.P. (1992). Interaction of butylated hydroxyanisole with mitochondrial oxidative phosphorylation. Biochem. Pharmacol., 43 (6), 1203-1208.(I.F. 2.129)3) Sgaragli G.P., Valoti M., Fusi F., Palmi M., Mantovani P., De Santi M.M., Lorenzini L., Tosi P. (1993). Toxic injury to rat gut musculature following intraperitoneal administration of 2-t-butyl-4-methoxyphenol. Eur. J. Pharmacol.,248, 121-129.(I.F. 2.849)4) Sgaragli G.P., Valoti M., Gorelli B., Fusi F., Palmi M., Mantovani P. (1993). Calcium antagonist and antiperoxidant properties of some hindered phenols. Br. J. Pharmacol.,110, 369-377.(I.F. 5.270)5) Zilletti L., Ciuffi M., Franchi-Micheli S., Fusi F., Gentilini G., Moneti G., Valoti M., Sgaragli G.P. (1994). Cyclooxygenase activity of hemoglobin. Methods Enzym., 231, 562-573. Hemoglobins, Part B. J. Everse Eds., Academic Press.(I.F. 1.545)6) Silvestri R., Pagnozzi E., Valoti M., Fusi F. (1994). Non-steroidal antiinflammatory agents. Synthesis and enzyme inhibition of 2-[4-(heteroarylmethyl)phenil] propanoic acids and analogues. Il Farmaco, 49 (10), 625-632.(I.F. 0.346)7) Mori F., Lai C., Fusi F., Giacobini E. (1995). Cholinesterase inhibitors increase secretion of APPs in rat brain cortex. NeuroReport, 6, 633-636.(I.F. 2.570)8) Petkov G., Fusi F., Boev K.K. (1995). Effects of cyclopiazonic acid on the phasic and tonic contractions in the smooth muscles of the guinea-pig and cat stomach. Compt. Rend. Bulg. Acad. Sci., 48 (8), 57-60.9) Palmi M., Fusi F., Youmbi G., Frosini M., Bianchi L., Della Corte L., Sgaragli G.P., Tipton K.F. (1996). Effects of taurine and structurally-related analogues on Ca2+-uptake and respiration rate in rat liver mitochondria. Adv. Exp. Med. Biol., 403, 117-124.(I.F. 0.446)10) Fusi F., Marazova K., Pessina F., Petri C., Sgaragli G.P. (1997). Can food antioxidants prevent cancer and cardiovascular diseases? Acta Phytotherapeutica, 3, 10-20.11) Palmi M., Youmbi G., Fusi F., Frosini M., Sgaragli G.P., Della Corte L., Bianchi L., Tipton K.F. (1998). Antagonism by taurine on the ruthenium red-induced and 6-hydroxydopamine plus 1-methyl-4-phenylpyridinium-induced Ca2+ release from rat liver mitochondria. Adv. Exp. Med. Biol., 442, 91-98.(I.F. 0.446)12) Fusi F., Gorelli B., Valoti M., Marazova K., Sgaragli G.P. (1998). Effects of 2,5-di-t-butyl-1,4-benzohydroquinone (BHQ) on rat aorta smooth muscle. Eur. J. Pharmacol., 346, 237-243.(I.F. 1.992)13) Fusi F., Valoti M., Petkov G., Boev K.K., Sgaragli G.P. (1998). Myorelaxant activity of 2-t-butyl-4-methoxyphenol (BHA) in guinea pig gastric fundus. Eur. J. Pharmacol., 360, 43-50.(I.F. 1.992)14) Fusi F., Valoti M., Frosini F., Sgaragli G.P. (1999). 2,5-Di-t-butyl-1,4-benzohydroquinone induces endothelium-dependent relaxation of rat thoracic aorta. Eur. J. Pharmacol., 366, 181-187.(I.F. 2.047)15) Frosini M., Sesti C., Valoti M., Palmi M., Fusi F., Parente L., Sgaragli G. (1999). Rectal temperature and prostaglandin E2 increase in cerebrospinal fluid of conscious rabbits after intracerebroventricular injection of hemoglobin. Exp. Brain Res., 126, 252-258. (I.F. 2.246)16) Palmi M., Youmbi G., Fusi F., Sgaragli G.P., Dixon H.B.F., Frosini M., Tipton K.F. (1999). Potentiation of mitochondrial Ca2+ sequestration by taurine. Biochem. Pharmacol., 58, 1123-1131.(I.F. 2.755)17) Palmi M., Tchuisseu Youmbi G., Sgaragli G.P., Meini A., Benocci A., Fusi F., Frosini M., Della Corte L., Davey G., Tipton K.F. (2000). The mitochondrial permeability transition and taurine. Adv. Exp. Med. Biol., 483, 87-96. (I.F. 0.513)18) Frosini M., Sesti C., Palmi M., Valoti M., Fusi F., Mantovani P., Bianchi L., Della Corte L., Sgaragli G.P. (2000). The possible role of taurine and GABA as endogenous cryogens in the rabbit. Adv. Exp. Med. Biol., 483, 335-344. (I.F. 0.513)19) Valoti M., Fusi F., Frosini M., Pessina F., Tipton K.F., Sgaragli G.P. (2000). Cytochrome P450-dependent N-dealkylation of l-deprenyl in C57BL mouse liver microsomes: effects of in vivo pretreatment with ethanol, phenobarbital, ?-naphthoflavone and l-deprenyl. Eur. J. Pharmacol., 391, 199-206.(I.F. 2.236)20) Fusi F., Marazova K., Pessina F., Gorelli B., Valoti M., Frosini M., Sgaragli G.P. (2000). On the mechanisms of the antispasmodic action of some hindered phenols in rat aorta rings. Eur. J. Pharmacol., 394, 109-115. (I.F. 2.236)21) Frosini M., Sesti C., Palmi M., Valoti M., Fusi F., Mantovani P., Bianchi L., Della Corte L., Sgaragli G. (2000). Heat-stress-induced hyperthermia alters CSF osmolality and composition in conscious rabbits. Am. J. Physiol. (Regul. Integr. Comp. Physiol.), 279, R2095-R2103.(I.F. 2.765)22) Fusi F., Saponara S., Gagov H., Sgaragli G.P. (2001). Effects of some sterically hindered phenols on whole-cell Ca2+ current of guinea pig gastric fundus smooth muscle cells. Br. J. Pharmacol.,132, 1326-1332.(I.F. 3.502)23) Fusi F., Saponara S., Gagov H., Sgaragli G.P. (2001). 2,5-Di-t-butyl-1,4-benzohydroquinone (BHQ) inhibits vascular L-type Ca2+ channel via superoxide anion generation. Br. J. Pharmacol., 133, 988-996.(I.F. 3.502)24) Pessina F., Kalfin R., Esposito L., Fusi F., Valoti M., Ponticelli F., Sgaragli G. (2001). Neuroprotection afforded by some hindered phenols and ?-tocopherol in guinea-pig detrusor strips subjected to anoxia-glucopenia and reperfusion-like conditions. Naunyn Schmiedeberg's Arch. Pharmacol., 364, 462-471.(I.F. 2.472)25) Petkov G.V., Fusi F., Saponara S., Gagov H., Sgaragli G.P., Boev K.K. (2001). Characterization of voltage-gated calcium currents in freshly isolated smooth muscle cells from rat tail main artery. Acta Physiol. Scand., 173, 257-265.(I.F. 1.660)26) Fusi F., Tzankova V., Valoti M., Pessina F., Sgaragli G.P. (2001). 3,5-Di-t-butyl-4-hydroxyanisole (DTBHA) activation of rat skeletal muscle sarcoplasmic reticulum Ca2+-ATPase. Biochem. Pharmacol., 62, 1613-1619.(I.F. 3.340)27) Saponara S., Sgaragli G., Fusi F. (2002). Quercetin as a novel activator of L-type Ca2+ channels in rat tail artery smooth muscle cells. Br. J. Pharmacol., 135, 1819-1827.(I.F. 3.45)28) Fusi F., Saponara S., Sgaragli G., Cargnelli G., Bova S. (2002). Ca2+ entry blocking and contractility promoting actions of norbormide in single rat caudal artery myocytes. Br. J. Pharmacol., 137, 323-328.(I.F. 3.45)29) Fusi F., Saponara S., Pessina F., Gorelli B., Sgaragli G. (2003). Effects of quercetin and rutin on vascular preparations. A comparison between mechanical and electrophysiological phenomena. Eur. J. Nutr., 42, 10-17.(I.F. 1.684)30) Bova S., Cavalli M., Cima L., Luciani S., Saponara S., Sgaragli G., Cargnelli G., Fusi F. (2003). Relaxant and Ca2+ channel blocking properties of norbormide on rat non-vascular smooth muscles. Eur. J. Pharmacol., 470, 185-191. (I.F. 2.352)31) Valoti M., Frosini M., Dragoni S., Fusi F., Sgaragli G.P. (2003). Pharmacokinetics of diphenhydramine in healthy volunteers with a dimenhydrinate 25 mg chewing gum formulation. Methods Find. Exp. Clin. Pharmacol., 25, 377-381.(I.F. 0.456)32) Fusi F., Saponara S., Frosini M., Gorelli B., Sgaragli G. (2003). L-type Ca2+ channels activation and contraction elicited by myricetin on vascular smooth muscles. Naunyn Schmiedeberg's Arch. Pharmacol., 368, 470-478.(I.F. 2.101)33) Saponara S., Kawase M., Shah A., Motohashi N., Molnar J., Ugocsai K., Sgaragli G., Fusi F. (2004). 3,5-Dibenzoyl-4-(3-phenoxyphenyl)-1,4-dihydro-2,6-dimethylpyridine (DP7) as a new multidrug resistance reverting agent devoid of effects on vascular smooth muscle contractility. Br. J. Pharmacol., 141, 415-422.(I.F. 3.325)34) Fusi F., Iozzi D., Sgaragli G., Frosini M. (2005). 3,5-Di-t-butylcatechol (DTCAT) as an activator of rat skeletal muscle ryanodine receptor Ca2+ channel (RyRC). Biochem. Pharmacol., 69, 485-491.(I.F. 3.617)35) Fusi F., Sgaragli G., Saponara S. (2005). Mechanism of myricetin stimulation of vascular L-type Ca2+ current. J. Pharmacol. Exp. Ther., 313, 790-797.(I.F. 4.098)36) Carosati E., Cruciani G., Chiarini A., Budriesi R., Ioan P., Spisani R., Spinelli D., Cosimelli B., Fusi F., Frosini M., Matucci R., Gasparrini F., Ciogli A., Stephens P.J., Devlin F.J. (2006). Calcium channel antagonists discovered by a multidisciplinary approach. J. Med. Chem., 49, 5206-5216. (I.F. 5.115)37) Saponara S., Testai L., Iozzi D., Martinotti E., Martelli A., Chericoni S., Sgaragli G., Fusi F., Calderone V. (2006). (+/-)-Naringenin as large conductance Ca2+-activated K+ (BKCa) channel opener in vascular smooth muscle cells. Br. J. Pharmacol., 149, 1013-1021.(I.F. 3.825)38) Fusi F., Ferrara A., Sgaragli G., Saponara S. (2007). Mechanisms of the antispasmodic activity of 3,5-di-t-butyl catechol (DTCAT) on rat vascular smooth muscles. Eur. J. Pharmacol., 561, 112-120.(I.F. 2.376)39) Saponara S., Ferrara A., Gorelli B., Shah A., Kawase M., Sgaragli G., Fusi F. (2007). 3,5-Dibenzoyl-4-(3-phenoxyphenyl)-1,4-dihydro-2,6-dimethylpyridine (DP7): a new multidrug resistance inhibitor devoid of effect on Langendorff-perfused rat heart. Eur. J. Pharmacol., 563, 160-163.(I.F. 2.376)40) Fusi F., Ferrara A., Zalatnai A., Molnar J., Sgaragli G., Saponara S. (2008). Vascular activity of two silicon compounds, ALIS 409 and ALIS 421, novel multidrug-resistance reverting agents in cancer cells. Cancer Chemother. Pharmacol., 61, 443-451.(I.F. 2.740)41) Fusi F., Ferrara A., Koorbanally C., Crouch N.R., Mulholland D.A., Sgaragli G. (2008). Vascular myorelaxing activity of isolates from South African Hyacinthaceae partly mediated by activation of soluble guanylyl cyclase. J. Pharm. Pharmacol., 60, 489-497.(I.F. 1.847)42) Carosati E., Budriesi R., Ioan P., Ugenti M.P., Frosini M., Fusi F., Corda G., Cosimelli B., Spinelli D., Chiarini A., Cruciani G. (2008). Discovery of novel and cardioselective diltiazem-like calcium channel blockers via virtual screening. J. Med. Chem., 51, 5552-5565.(I.F. 4.898)43) Saponara S., Sgaragli G., Fusi F. (2008). Quercetin antagonism of Bay K 8644 effects on rat tail artery L-type Ca2+ channels. Eur. J. Pharmacol., 598, 75-80.(I.F. 2.787)44) Bova S., Saponara S., Rampa A., Gobbi S., Cima L., Fusi F., Sgaragli G., Cavalli M., De los Rios C., Striessnig J., Bisi A. (2009). Anthracene based compounds as new L-type Ca2+ channel blockers: design, synthesis, and full biological profile. J. Med. Chem., 52, 1259-1262.(I.F. 4.802)45) Budriesi R., Cosimelli B., Ioan P., Ugenti M.P., Carosati E., Frosini M., Fusi F., Saponara, S., Cruciani G., Novellino E., Spinelli D., Chiarini A. (2009). L-Type calcium channel blockers: from diltiazem to 1,2,4-oxadiazol-5-ones via thiazinooxadiazol-3-one derivatives. J. Med. Chem., 52, 2352-2362. (I.F. 4.802)46) Carosati E., Budriesi R., Ioan P., Cruciani G., Fusi F., Frosini M., Saponara S., Gasparrini F., Ciogli A., Villani C., Stephens P.J., Devlin F.J., Spinelli D., Chiarini A. (2009). Stereoselective behavior of the functional diltiazem analogue 1-[(4-chlorophenyl)sulfonyl]-2-(2-thienyl)pyrrolidine, a new L-type calcium channel blocker. J. Med. Chem., 52, 6637-6648. (I.F. 4.802)47) Fusi F., Cavalli M., Mulholland D., Crouch N.R., Coombes P., Dawson G., Bova S., Sgaragli G., Saponara S. (2010). Cardamonin is a bifunctional vasodilator that inhibits Cav1.2 current and stimulates KCa1.1 current in rat tail artery myocytes. J. Pharmacol. Exp. Ther., 332, 531-540.(I.F. 4.017)48) Saponara S., Carosati E., Mugnai P., Sgaragli G., Fusi F.(2011). The flavonoid scaffold as a template for the design of modulators of the vascular Cav1.2 channels. Br. J. Pharmacol., 164, 1684-1697.(I.F. 4.409)49) Saponara S., Gorelli B., Tzankova V., Martelli C., Teodori·E., Sgaragli G., Fusi F. (2011). The novel potent multidrug resistance inhibitors N,N-bis(cyclohexanol)amine aryl esters are devoid of vascular effects. Pharmacology, 88, 137-141.(I.F. 1.788)50) Lacava C., Sgaragli G., Fusi F. (2012). 3,5-Di-t-butylcatechol as a ryanodine receptor agonist in rat intact skeletal muscle fibers. Drug Dev. Res., 73, 138-145.(I.F. 0.869)51) Fusi F., Sgaragli G., Ha L.M., Cuong N.M., Saponara S. (2012). Mechanism of osthole inhibition of vascular Cav1.2 current. Eur. J. Pharmacol., 680, 22-27.(I.F. 2.592)52) Lacava C., Michalek-Sauberer A.,Kraft B., Sgaragli G.,Sipos E., H?ller C., Kress H.G., Fusi F., Weigl L.G. (2012). 3,5-Di-t-butyl catechol is a potent human ryanodine receptor 1 activator, not suitable for the diagnosis of malignant hyperthermia susceptibility. Pharmacol. Res., 66, 80-87.(I.F. 4.346)53) Saponara S., Fusi F., Sgaragli G., Cavalli M., Hopkins B., Bova S. (2012). Effects of commonly used protein kinase inhibitors on vascular contraction and L-type Ca2+ current. Biochem. Pharmacol., 84, 1055-1061.(I.F. 4.576)54) Durante M., Sgaragli G., Biasutto L., Mattarei A., Fusi F. (2013). Quercetin mitochondriotropic derivatives antagonize nitrate tolerance and endothelial dysfunction of isolated rat aorta rings. Planta Med., 79, 465-467.(I.F. 2.339)55) Iozzi D., Schubert R., Kalenchuk V.U., Neri A., Sgaragli G., Fusi F., Saponara S. (2013). Quercetin relaxes rat tail main artery partly via a PKG-mediated stimulation of KCa1.1 channels. Acta Physiol., 208, 329-339.(I.F. 4.251)56) Fusi F., Durante M., Sgaragli G., Cuong N.M., Dung P.T.P., Nam N.H. (2013). 2-Aryl- and 2-amido-benzothiazoles as multifunctional vasodilators on rat artery preparations. Eur. J. Pharmacol., 714, 178-187.(I.F. 2.684)57) Ferrara A., Fusi F., Gorelli B., Sgaragli G., Saponara S. (2014). Freeze-dried red wine effects on cardiac function and ECG of the Langendorff-perfused rat heart. Can. J. Physiol. Pharm., 92, 171-174.(I.F. 1.770)58) Cuong N.M., Khanh P.N., Duc H.V., Huong T.T., Tai B.H., Binh N.Q., Durante M. and Fusi F. (2014). Vasorelaxing activity of two coumarins from Murraya paniculata leaves. Biol. Pharm. Bull., 37, 694-697. (I.F. 1.828)59) Mugnai P., Durante M., Sgaragli G., Saponara S., Paliuri G., Bova S., Fusi F. (2014). L-type Ca2+ channel current characteristics are preserved in rat tail artery myocytes after one-day storage. Acta Physiol., 211, 334-345.(I.F. 4.382)60) Cuong N.M., Khanh P.N., HuyenP.T., Duc H.V., Huong T.T., Ha V.T., Durante M., Sgaragli G., Fusi F. (2014). Vascular L-type Ca2+ channel blocking activity of sulphur-containing indole alkaloids from Glycosmis petelotii. J. Nat. Prod., 77, 1586-1593.(I.F. 3.798)61) Spinelli D., Budriesi R., Cosimelli B., Severi E., Micucci M., Baroni M., Fusi F., Ioan P., Cross S., Frosini M., Saponara S., Matucci R., Rosano C., Viale M., Chiarini A., Carosati E. (2014). Playing with opening and closing of heterocycles: using the Cusmano-Ruccia reaction to develop a novel class of oxadiazolothiazinones, active as calcium channel modulators and p-glycoprotein inhibitors. Molecules, 19, 16543-16572.(I.F. 2.416)62) Fusi F., Sgaragli G. (2015). Reversion of nitrate tolerance in rat aorta rings by freeze-dried red wine. Phytother. Res., 29,628-631. (I.F. 2.694)63) Fusi F., Durante M., Sgaragli G., Khanh P.N., Son N.T., Huong T.T., Huong N.V., Cuong N.M. (2015). In vitro vasoactivity of zerumbone from Zingiber zerumbet. Planta Med., 81, 298-304.(I.F. 1.990)64) Saponara S., Durante M., Spiga O., Mugnai P., Sgaragli G., Huong T.T., Khanh P.N., Son N.T., Cuong N.M., Fusi F. (2016). Functional, electrophysiological and molecular docking analysis of the modulation of Cav1.2 channels in rat vascular myocytes by murrayafoline A. Br. J. Pharmacol., 173, 292-304.(I.F. 5.491)65) Fusi F., Manetti F., Durante M., Sgaragli G., Saponara S. (2016). The vasodilator papaverine stimulates L-type Ca2+ current in rat tail artery myocytes via a PKA-dependent mechanism. Vasc. Pharmacol., 76, 53-61.(I.F. 3.718)66) Carosati E., Cosimelli B., Ioan P., Severi E., Katneni K., Chiu F.C.K., Saponara S., Fusi F., Frosini M., Matucci R., Micucci M., Chiarini A., Spinelli D., Budriesi R. (2016). Understanding oxadiazolothiazinone biological properties: negative inotropic activity versus cytochrome p450-mediated metabolism. J. Med. Chem., 59, 3340-3352.(I.F. 6.259)67) Fusi F., Durante M., Spiga O., Trezza A., Frosini M., Floriddia E., Teodori E., Dei S., Saponara S. (2016). In vitro and in silico analysis of the vascular effects of asymmetrical N,N-bis(alkanol)amine aryl esters, novel multidrug-resistance reverting agents. Naunyn Schmiedeberg's Arch. Pharmacol., 389, 1033-1043.(I.F. 2.558)68) D’Amore C., Orso G., Fusi F., Pagano M.A., Miotto G., Forgiarini A., De Martin S., Castellani G., Ribaudo G., Rennison D., Brimble M.A., Hopkins B., Ferrarese A., Bova S. (2016). An NBD derivative of the selective rat toxicant norbormide as a new probe for living cell imaging. Front. Pharmacol., 7, 315.(I.F. 4.400)69) Fusi F., Durante M., Sticozzi C., Frosini M., Perrone M.G., Colabufo N.A., Saponara S. (2017). Vascular toxicity risk assessment of MC18 and MC70, novel potential diagnostic tools for in vivo PET studies. Basic. Clin. Pharmacol. Toxicol., 120, 434-441.(I.F. 2.659)70) Fusi F., Trezza A., Spiga O., Sgaragli G., Bova S. (2017). CaV1.2 channel current block by the PKA inhibitor H-89 in rat tail artery myocytes via a PKA-independent mechanism: electrophysiological, functional, and molecular docking studies. Biochem. Pharmacol., 140, 53-63.(I.F. 4.235)71) Durante M., Frosini M., Fusi F., Neri A., Sticozzi C., Saponara S. (2017). In vitro vascular toxicity of tariquidar, a potential tool for in vivo PET studies. Toxicol. In Vitro, 44, 241-247.(I.F. 3.105)72) Fusi F., Durante M., Gorelli B., Perrone M.G., Colabufo N.A., Saponara S. (2017). MC225, a novel probe for P-glycoprotein PET imaging at the blood-brain barrier: in vitro cardiovascular safety evaluation. J. Cardiovasc. Pharmacol., 70, 405-410.(I.F. 2.227)73) Fusi F., Sgaragli G., Valoti M. (2018). Gold nanoparticles potentiate CaV channel currents in rat tail artery myocytes. Toxicol. In Vitro, 47, 89-93.(I.F. 3.067)74) Saponara S., Fusi F., Saponara S., Macucci M., Groza V. (2018). Interference measurements and failure analysis of patch-clamp laboratory instrumentation for electrophysiology tests. IEEE Instrum. Meas. Mag., 21, 50-57.(I.F. 1.024)75) Vallone A., D'Alessandro S., Brogia S., Brindisi M., Chemi G., Alfano G., Lamponi S., Goo Lee S., Jez J.M., Koolen K.J.M., Dechering K.J., Saponara S., Fusi F., Gorelli B., Taramelli D., Parapini S., Caldelari R., Campiani G., Gemma S., Butini S. (2018). Antimalarial agents against both sexual and asexual parasites stages: structure-activity relationships and biological studies of the Malaria Box compound 1-[5-(4-bromo-2-chlorophenyl)furan-2-yl]-N-[(piperidin-4-yl)methyl]methanamine (MMV019918) and analogues. Eur. J. Med. Chem., 150, 698-718.(I.F. 4.833)76) Trezza A., Cicaloni V., Porciatti P., Langella A., Fusi F., Saponara S., Spiga O. (2018). From in silico to in vitro: a trip to reveal flavonoid binding on the Rattus norvegicus Kir6.1 ATP-sensitive inward rectifier potassium channel. PeerJ 6:e4680.(I.F. 2.353)77) Carullo G., Durante M., Sciubba F., Restuccia D., Spizzirri U.G., Ahmed A., Di Cocco ?M.E., Saponara S.?, Aiello F., Fusi F. (2019). Vasoactivity of Mantonico and Pecorello grape pomaces on rat aorta rings: An insight into nutraceutical development. J. Funct. Foods, 57, 328-334.(I.F. 3.701)78) Saponara S., Fusi F., Spiga O., Trezza A., Hopkins B., Brimble M.A., Rennison D., Bova S. (2019). The selective rat toxicant norbormide blocks KATP channels in smooth muscle cells but not in insulin-secreting cells. Front. Pharmacol., 10, 598. (I.F. 4.225)(I.F. tot 222.687)/77 paper(I.F./paper 2.892)79) Cuong N.M., Son N.T., Nhan N.T., Khanh P.N., Huong T.T., Tram N.T.T., Sgaragli G., Ahmed A., Trezza A., Spiga O., Fusi F. (2020) Vasorelaxing activity of R-(–)-3'-hydroxy-2,4,5-trimethoxydalbergiquinol from Dalbergia tonkinensis: involvement of smooth muscle CaV1.2 channels. Planta Med., 86, 284-293.(I.F. 2.687)80) Fusi F., Trezza A., Sgaragli G., Spiga O., Saponara S., Bova S. (2020). Ritanserin blocks CaV1.2 channels in rat artery smooth muscles: electrophysiological, functional, and computational studies. Acta Pharmacol. Sin., in press.(I.F. 5.064)81) Waratchareeyakul W., Fusi F., Durante M., Ahmed A., Knirsch W., Mas-Claret E., Mulholland D.A. (2020). Vasorelaxing activity of stilbenoid and phenanthrene derivatives from Brasiliorchis porphyrostele: involvement of smooth muscle CaV1.2 channels. Planta Med., 86, 631-642.(I.F. 2.687)82) Carullo G., Ahmed A., Fusi F., Sciubba F., Di Cocco M.E., Restuccia D., Spizzirri U.G., Saponara S., Aiello F. (2020). Vasorelaxant effects induced by red wine and pomace extracts of Magliocco dolce cv. Pharmaceuticals, 13, 87.(I.F. 4.286)83) Durante M., Frosini M., Fusi F., Gamberucci A., Chegaev K., Rolando B., Riganti C., Fruttero R., Saponara S. (2020). In vitro vascular toxicity assessment of NitDOX, a novel NO-releasing doxorubicin. Eur. J. Pharmacol., 880, 173164.(I.F. 3.263)84) Pessina F., Frosini M., Marcolongo P., Fusi F., Saponara S., Gamberucci A., Valoti M., Giustarini D., Fiorenzani P., Gorelli B., Francardi V., Botta M., Dreassi E. (2020). Antihypertensive, cardio- and neuro-protective effects of Tenebrio molitor (Coleoptera: Tenebrionidae) defatted larvae in spontaneously hypertensive rats. PLoS ONE, 15(5), e0233788.(I.F. 2.740)CHAPTERS OF BOOKS1) Sgaragli G.P., Fusi F., Gorelli B. (1993). Methods of investigation of calcium metabolism in smooth muscle cells. Training Course in Biochemical Pharmacology, Book of the Course.2) Benocci A., Frosini M., Fusi F., Gorelli B., Marazova K., Sgaragli G.P. Current methods for studying cell calcium (1997). Biochemical Pharmacological Techniques: Theoretical & Experimental Aspects. Book of the Course.3) Fusi F., Saponara S., Gagov H., Sgaragli G.P. (1999). The patch-clamp technique: development and uses to investigate Ca2+ currents. Gli Atti dell'Accademia delle Scienze di Siena detta de' Fisiocritici, serie XV, tomo XVIII, 89-99.4) Valoti M., Fusi F., Sgaragli G.P. (2001). Phenolic antioxidants with calcium antagonist properties: the need for novel, more specific food antioxidant. Fair Conference on Food Antioxidants and Human Health. Ed. Sgaragli G.P., Valoti M. pp. 57-67.5) Fusi F., Saponara S., Pessina F., Gorelli B., Sgaragli G.P. (2002). Effects of wine polyphenols on vascular functions: an electro-mechanic investigation. Bioactive Compounds in Plant Foods. Health Effects and Perspectives for the Food Industry.Ed. Amadò R., Abt B., Bravo L., Go?i I., Saura-Calixto F. pp. 108-109.6) Fusi F., Saponara S., Sgaragli G.P. (2004). Effetto della quercetina e di alcuni flavonoidi ad essa strutturalmente correlati, sulle correnti di Ca2+ di tipo L in cellule muscolari lisce isolate dall’arteria principale della coda di ratto. Annali piante officinali, vol. 8, pp. 46-47.7) Saponara S., Fusi F., Saponara S., Macucci M. (2018). Failure effect analysis of patch-clamp electronic instrumentation in electrophysiology experiments. In: De Gloria A. (eds) Applications in Electronics Pervading Industry, Environment and Society. ApplePies 2016. Lecture Notes in Electrical Engineering, vol. 429. pp. 138-144 Springer, Cham.8) Durante M., Frosini M., Fusi F., Rolando B., Chegaev K., Saponara S. In vitro assessment of NitDox toxicity towards vasculature. In: Therapeutic Applications of Nitric Oxide in Cancer and Inflammatory Disorders. Ed: Bonavida B, Morbidelli L, Elsevier Science, ISBN: 978-0-12-816545-4.ABSTRACTS1) Fusi F., Valoti M., Gorelli B., Mantovani P. and Sgaragli G.P. (1992). Calcium antagonist properties on rat ileum longitudinal muscle of 2-t-butyl-4-methoxyphenol (BHA). Pharmacol. Res., 26 (suppl. 1), 322.2) Zilletti L., Gentilini M.G., Franchi-Micheli S., Mugnai S., Ciuffi M., Valoti M., Moneti G., Fusi F. and Sgaragli G.P. (1992). Cyclooxygenase activity of haemoglobin: a comparative study in different species. Pharmacol. Res., 26 (suppl. 1), 266.3) Valoti M., Fusi F., Gorelli B., Palmi M. and Sgaragli G.P. (1993). Nifedipine-like properties in normal and skinned ileum longitudinal muscle in rat and antiperoxidant activities of some hindered phenols. Pharmacol. Res., 27 (suppl. 1), 69-70.4) Fusi F., Valoti M., Petkov G., Boev K.K. and Sgaragli G.P. (1994). Effects of 2-t-butyl-4-methoxyphenol (BHA) on plasmalemma and intracellular Ca2+ transport in guinea pig gastric fundus smooth muscle. Br. J. Pharmacol.,111, 251P.5) Zilletti L., Ciuffi M., Franchi-Micheli S., Fusi F., Gentilini G., Mugnai S., Valoti M. and Sgaragli G.P. (1994). Metabolism of arachidonate catalysed by haemoglobin. Br. J. Pharmacol.,111, 73P.6) Zilletti L., Ciuffi M., Franchi-Micheli S., Fusi F., Gentilini G., Moneti G., Valoti M., Mugnai S. and Sgaragli G.P. (1994). Metabolism of arachidonic acid catalysed by haemoglobin. Pharmacol. Res., 30 (4), 347.7) Valoti M., Fusi F. and Sgaragli G.P. (1994). Free radicals inactivation by some antioxidant hindered phenols in biological systems. Pharmacol. Res., 30 (4), 348-349.8) Fusi F., Valoti M., Petkov G., Boev K.K. and Sgaragli G.P. (1994). Effects of BHA on plasmalemmal and intracellular Ca2+ transport in guinea pig gastric fundus. Pharmacol. Res., 30 (4), 349-350.9) Gorelli B., Pessina F., Fusi F., Valoti M., Marazova K. and Sgaragli G.P. (1995). Calcium antagonist properties of some hindered phenols on rat aortic rings. Pharmacol. Res., 31 (suppl.), 206.10) Fusi F., Conforti L., Scarlett J.A. and Callingham B.A. (1995). The effect of allylamine on the tension responses of cervine digital arteries in vitro to noradrenaline. Br. J. Pharmacol., 116, 414P.11) Frosini M., Fusi F., Palmi M., Bianchi L., Della Corte L. and Sgaragli G.P. (1996). Taurine and calcium changes in rabbit CSF during exposure to high temperatures. Eur. J. Neurosci., 9 (suppl.), 41.12) Palmi M., Fusi F., Youmbi G., Frosini M., Sgaragli G.P., Della Corte L., Bianchi L. and Tipton K.F. (1996). Effects of taurine on Ca2+ uptake and oxidative phosphorylation in mitochondria. Eur. J. Neurosci., 9 (suppl.), 41.13) Fusi F., Galgani F., Gorelli B., Valoti M. and Sgaragli G.P. (1997). Pleiotypic effects of 2,5-di-t-butyl-1,4-benzohydroquinone (BHQ) on vascular smooth muscle. Pharmacol. Res., 35 (suppl.), 77.14) Fusi F., Conforti L., Scarlett J.A. and Callingham B.A. (1997). The effect of allylamine on cervine vascular reactivity. Pharmacol. Res., 35 (suppl.), 225-226.15) White R., Fusi F., Scarlett J.A. and Callingham B.A. (1997). Seasonal differences in the reactivity of fallow deer digital artery. J. Auton. Pharmacol., 17, 217.16) Fusi F., Tzankova V., Galgani F., Valoti M. and Sgaragli G.P. (1999). Effect of 3,5-di-t-butyl-4-hydroxyanisole (DTBHA) on sarcoplasmic reticulum Ca2+-ATPase of rat skeletal muscle. Pharmacol. Res., 39 (suppl.), 26.17) Fusi F., Saponara S., Gorelli B., Alov P., Pessina F. and Sgaragli G.P. (1999). Antispasmodic and antioxidant properties of some newly synthesised hindered phenols. Pharmacol. Res., 39 (suppl.), 88.18) Petkov G.V., Gagov H.S., Fusi F., Corsi M., Sgaragli G.P. and Boev K.K. (1999). Calcium current in freshly isolated smooth muscle cells from rat tail artery. Pharmacol. Res., 39 (suppl.), 54.19) Petkov G.V., Gagov H.S., Fusi F., Sgaragli G.P. and Boev K.K. (1999). Effects of t-butyl phenols on calcium current in smooth muscle cells. Pharmacol. Res., 39 (suppl.), 54.20) Fusi F., Saponara S., Gagov H. and Sgaragli G.P. (2001). 2,5-Di-t-butyl-1,4-benzohydroquinone (BHQ) inhibition of vascular L-type Ca2+ channel is mediated by superoxide anion. Pharmacol. Res., 43 (suppl. A), 23.21) Saponara S., Fusi F., Pessina F., Gorelli B., Vittori L. and Sgaragli G.P. (2001). Effects of quercetin on vascular smooth muscle. Pharmacol. Res., 43 (suppl. A), 24.22) Saponara S., Kawase M., Shah A., Motohashi N., Molnar J., Ugocsai K., Sgaragli G. and Fusi F. (2004). 3,5-Dibenzoyl-4-(3-phenoxyphenyl)-1,4-dihydro-2,6-dimethylpyridine (DP7) as a new MDR reverter devoid of vascular effects. J Chemother., 16 (suppl. 1).23) Dragoni S., Valoti M., Fusi F., Saponara S. and Sgaragli G.P. (2006). Red wine and health. Phytother. Res., 20, 327-328.24) Schubert R., Saponara S., Fusi F., Iozzi D. (2007). The flavonoid quercetin relaxes arteries by decreasing cytosolic and stored calcium. Acta Physiol.,189 (suppl. 653)O02-2.25) Saponara S., Iozzi D., Fusi F., Sgaragli G. (2008). Plant polyphenols as modulators of vascular ion channels. Acta Biochim. Pol., 55(suppl. 1), 26-27.26) Saponara S., Fusi F., Sgaragli G. (2008). Quercetin antagonism of Bay K 8644 effects on rat tail artery L-type Ca2+ channels. Fundam. Clin. Pharmacol., 22 (suppl 2), 62.27) Lacava C., Michalek-Sauberer A., Kraft B., Sgaragli G., Sipos E., H?ller C., KressH-G., Fusi F., Weigl L.G.(2009). 3,5-Di-t-butyl catechol (DTCAT) as an activator of the human skeletal muscle ryanodine receptor Ca2+ channel and its evaluation as a test substance for the assessment of susceptibility to malignant hyperthermia. BMC Pharmacology, 9(Suppl 2):A22.28) Fusi F. (2011). Vascular ion channels as targets of wine polyphenols and their metabolites: a possible explanation for their beneficial health effects. Eur. J. Nutr., 50, 491.29) Saponara S., Durante M., Frosini M., Gorelli B., Valoti M., Chegaev K., Sgaragli G., Fusi F. (2014). Screening for potential hazard effects from multitarget anthracycline on the cardiovascular system. Anticancer Res., 34, 6153.30) Waratchareeyakul W., Rocco A.,Fusi F., Schwikkard S.L., Knirsch W., Mulholland D.A. (2015). Vasorelaxant studies on stilbenoids and phenanthrene derivatives from Brasiliorchis porphyrostele Rchb.f. (Orchidaceae). Planta Med., 81, 16.31) Saponara S., Frosini M., Durante M., Riganti C., Gazzano E., Chegaev K., Fusi F. (2016). Screening for potential hazardous effects of an H2S-donating anthracycline on the cardiovascular system. Intrinsic Activity, 4 (Suppl. 3), A1.432) Frosini M., Durante M., Fusi F., Sticozzi C., Saponara S. (2016). In vitro assessement of tariquidar toxicity towards vasculature. Intrinsic Activity, 4 (Suppl. 3), A1.5.33) Durante M., Fusi F., Frosini M., Sticozzi C., Capparelli E., Perrone M.G., Colabufo N.A., Saponara S. (2016). Vascular toxicity risk assessment of MC18 and MC70, novel potential diagnostic tools for in vivo PET studies. Intrinsic Activity, 4 (Suppl. 3), A1.6.34) Saponara S., Fusi F., Saponara S., Macucci M., Groza V. (2017). Failure mode and effect analysis of patch-clamp laboratory instrumentation for electrophysiology measurements. 2017 IEEE International Symposium on Medical Measurements and Applications, MeMeA 2017. Proceedings 7985853, 78-82.NATIONAL AND INTERNATIONAL MEETINGS1) Valoti M., Fusi F., Zilletti L. and Sgaragli G.P. (1990). Peroxidation under anaerobic conditions of arachidonic acid catalyzed by horseradish peroxidase in the presence of hydroperoxide(s) of arachidonic acid. 7th International Conference on Prostaglandins and Related Compounds. Florence, Italy, May 28-June 1.2) Valoti M., Fusi F., Gorelli B., Palmi M. and Sgaragli G.P. (1991). Nifedipine-like properties in normal and skinned ileum longitudinal muscle in rat and antiperoxidant activities of some hindered phenols.VI Meeting of the Italian Society of Pharmacognosy. Rome, Italy, October 10-12.3) Fusi F., Valoti M., Gorelli B., Mantovani P. and Sgaragli G.P. (1992). Calcium antagonist properties on rat ileum longitudinal muscle of 2-t-butyl-4-methoxyphenol (BHA). XXVI National Congress of the Italian Society of Pharmacology. Naples, Italy, September 29-October 3.4) Zilletti L., Gentilini M.G., Franchi-Micheli S., Mugnai S., Ciuffi M., Valoti M., Moneti G., Fusi F. and Sgaragli G.P. (1992). Cyclooxygenase activity of haemoglobin: a comparative study in different species. XXVI National Congress of the Italian Society of Pharmacology. Naples, Italy, September 29-October 3.5) Zilletti L., Ciuffi M., Franchi-Micheli S., Fusi F., Gentilini G., Moneti G., Valoti M. and Sgaragli G.P. (1993). Haemoglobin-catalyzed metabolism of arachidonic acid. Riunione monotematica nazionale of the Italian Society of Pharmacology. Siena, Italy, May 24.6) Valoti M., Fusi F. and Sgaragli G.P. (1993). Free radical inactivation by some antioxidant hindered phenols in biological systems. Riunione monotematica nazionale of the Italian Society of Pharmacology. Siena, Italy, May 24.7) Fusi F., Valoti M., Petkov G., Boev K.K. and Sgaragli G.P. (1993). Effects of BHA on plasmalemmal and intracellular Ca2+ transport in guinea pig gastric fundus smooth muscle. Riunione monotematica nazionale of the Italian Society of Pharmacology. Siena, Italy, May 24.8) Fusi F., Valoti M., Gorelli B., and Sgaragli G.P. (1993). Calcium antagonist and antiperoxidant properties of hindered phenols.International meeting on: Pathophysiology of the prooxidant/antioxidant balance. Molecular basis of medical application. Siena, Italy, June 24-26.9) Fusi F., Valoti M., Gorelli B. and Sgaragli G.P. (1993). Calcium antagonist properties of antioxidant hindered phenols. International symposium on antioxidant and disease prevention. Stockholm, Sweden, June 30-July 3.10) Fusi F., Valoti M., Petkov G., Boev K.K. and Sgaragli G.P. (1993). Effects of BHA on plasmalemmal and intracellular Ca2+ transport in guinea pig gastric fundus smooth muscle. V Joint meeting between the British and Italian Societies of Pharmacology. Rome, Italy, September 13-16.11) Zilletti L., Ciuffi M., Franchi-Micheli S., Fusi F., Gentilini G., Mugnai S., Valoti M. and Sgaragli G.P. (1993). Metabolism of arachidonate catalyzed by haemoglobin. V Joint meeting between the British and Italian Societies of Pharmacology. Rome, Italy, September 13-16.12) Fusi F., Valoti M., Petkov G., Boev K.K. and Sgaragli G.P. (1994). Meccanismi dell'azione spasmolitica del BHA sulla muscolatura liscia isolata dal fondo di stomaco di cavia. Metodi Innovativi in Farmacologia, Gruppo Nazionale MURST 40%. Florence, Italy, May 30.13) Fusi F. (1994). Derivati fenolici di origine naturale o sintetici con proprietà antiossidanti e calcioantagonistiche come farmaci per la prevenzione dei danni tissutali da ischemia-riperfusione susseguenti a infarto miocardico e ictus cerebrale. National Meeting of Ph.D. Students in Pharmaceutical Sciences, Urbino, Italy, September 5-9.14) Fusi F., Valoti M., Petkov G., Boev K.K. and Sgaragli G.P. (1994). Spasmolysis by 2-t-butyl-4-methoxyphenol in guinea pig gastric fundus smooth muscle contracted with cyclopiazonic acid or tetraethylammonium. 6th International Symposium on Pharmacological control of calcium and potassium homeostasis. Florence, Italy, October 4-6.15) Giacobini E., Mori F., Lai C-C., and Fusi F. (1995). The effect of cholinesterase inhibitors on the secretion of APPs from in rat brain cortex. In: Novel Therapeutic Approaches to AD and other Memory Disorders Associated with Aging. Zurich, Switzerland.16) Gorelli B., Pessina F., Fusi F., Valoti M., Marazowa K. and Sgaragli G.P. (1995). Calcium antagonist properties of some hindered phenols on rat aortic rings. First European Congress of Pharmacology. Milan, Italy, June 16-19.17) Palmi M., Fusi F., Youmbi G., Frosini M., Sgaragli G.P., Dixon H. and Tipton K.F. (1995). Effects of taurine and structurally-related analogues on Ca2+-uptake and respiration rate in rat liver mitochondria. International Taurine Symposium '95. Taurine: basic and clinical aspects. Osaka, Japan, June 27-July 1.18) Sgaragli G.P., Frosini M., Palmi M., Fusi F., Sesti C., Della Corte L., Bianchi L., Galeffi F., Bolam P., Dixon H. and Tipton K.F. (1995). Behavioural and cellular studies on some compounds structurally-related to taurine. International Taurine Symposium '95. Taurine: basic and clinical aspects. Osaka, Japan, June 27-July 1.19) Fusi F., Conforti L., Scarlett J.A. and Callingham B.A. (1995). The effect of allylamine on the tension responses of cervine digital arteries in vitro to noradrenaline. Autumn Meeting of the British Pharmacological Society, University of Strathclyde, Glasgow, U.K., September 6-8.20) Fusi F., Gorelli B., Pessina F., Valoti M., Marazova K. and Sgaragli G.P. (1995). Proprietà calcio antagonistiche di alcuni derivati fenolici su anelli di aorta di ratto. Metodi Innovativi in Farmacologia, Gruppo Nazionale MURST 40%. Florence, Italy, October 20-21.21) Fusi F., Conforti L., Scarlett J.A. and Callingham B.A. (1995). The effect of allylamine on cervine vascular reactivity. Riunione congiunta monotematica delle Società Italiane di Farmacologia e di Tossicologia sul metabolismo degli xenobiotici. Siena, Italy, November 3-4.22) White R., Fusi F., Scarlett J.A. and Callingham B.A. (1996). Seasonal differences in the reactivity of fallow deer digital artery. 9th Meeting on Adrenergic Mechanisms. Porto, Portugal, September 22-25.23) Frosini M., Fusi F., Palmi M., Bianchi L., Della Corte L. and Sgaragli G.P. (1996). Taurine and calcium changes in rabbit CSF during exposure to high temperatures. 2nd Meeting of European Neuroscience. Strasbourg, France, September 24-28.24) Palmi M., Fusi F., Youmbi G., Frosini M., Sgaragli G.P., Della Corte L., Bianchi L. and Tipton K.F. (1996). Effects of taurine on Ca2+ uptake and oxidative phosphorylation in mitochondria. 2nd Meeting of European Neuroscience. Strasbourg, France, September 24-28.25) Frosini M., Fusi F., Palmi M., Bianchi L., Della Corte L. and Sgaragli G.P. (1996). Concentrazioni di taurina e Ca2+ nel CSF di coniglio durante esposizione ad alte temperature. V Convegno Nazionale Giovani Cultori delle Neuroscienze. Pisa, Italy, December 12-14.26) Fusi F., Galgani F., Gorelli B., Valoti M. and Sgaragli G.P. (1997). Pleiotypic effects of 2,5-di-t-butyl-1,4-benzohydroquinone (BHQ) on vascular smooth muscle. XXVIII National Congress of the Italian Society of Pharmacology. Bari, Italy, April 30 - May 3.27) Palmi M., Youmbi G., Fusi F., Frosini M., Sgaragli G.P., Della Corte L., Bianchi L. and Tipton K.F. (1997). Effect of taurine on calcium transport in rat liver mitochondria. International Taurine Symposium '97. Neurochemistry, biochemistry and pharmacology. Tucson, Arizona, USA, July 15-19.28) Fusi F., Galgani F., Gorelli B., Valoti M. and Sgaragli G.P. (1998). Pleiotypic effects of 2,5-di-t-butyl-1,4-benzohydroquinone (BHQ) on vascular smooth muscle. First Virtual Congress about Pharmacy (IVCP), University of Granada, Faculty of Pharmacy, Research Group of Pharmaceutical Physical Chemistry (PAI), Computing and Network Communications Services Centre, Spain, January-December 1998.29) Fusi F., Corsi M., Pessina F., Galgani F. and Sgaragli G.P. (1998). Effects of 2,5-di-t-butyl-1,4-benzohydroquinone (BHQ) on rat aorta endothelium-dependent relaxation. 6th joint meeting of the Italian, Hungarian and Polish pharmacological societies. Pisa, Italy, May 14-16.30) Tchuisseu Youmbi G., Palmi M., Fusi F., Frosini M., Sgaragli G.P., Della Corte L. and Tipton K.F. (1998). Effects of taurine on Ca2+ transport in rat liver mitochondria. 6th joint meeting of the Italian, Hungarian and Polish pharmacological societies. Pisa, Italy, May 14-16.31) Pessina F., Marazova K., Gorelli B., Fusi F. and Sgaragli G.P. (1998). Antispasmodic effects of some sterically hindered phenols on rat aorta ring preparations. 6th joint meeting of the Italian, Hungarian and Polish pharmacological societies. Pisa, Italy, May 14-16.32) Fusi F., Corsi M., Pessina F., Galgani F. and Sgaragli G.P. (1998). Effects of 2,5-di-t-butyl-1,4-benzohydroquinone (BHQ) on rat aorta endothelium-dependent relaxation. International symposium on cell injury from reperfusion and oxidative stress: new pharmacological strategies for neuroprotection. Siena, Italy, November 9.33) Tzankova V., Fusi F., Galgani F., Valoti M. and Sgaragli G.P. (1998). Effect of some phenol derivatives on sarcoplasmic reticulum Ca2+-ATPase of rat skeletal muscle. International symposium on cell injury from reperfusion and oxidative stress: new pharmacological strategies for neuroprotection. Siena, Italy, November 9.34) Fusi F., Tzankova V., Galgani F., Valoti M. and Sgaragli G.P. (1999). Effect of 3,5-di-t-butyl-4-hydroxyanisole (DTBHA) on sarcoplasmic reticulum Ca2+-ATPase of rat skeletal muscle. XXIX National Congress of the Italian Society of Pharmacology. Florence, Italy, June 20-23.35) Fusi F., Saponara S., Gorelli B., Alov P., Pessina F. and Sgaragli G.P. (1999). Antispasmodic and antioxidant properties of some newly synthesised hindered phenols. XXIX National Congress of the Italian Society of Pharmacology. Florence, Italy, June 20-23.36) Petkov G.V., Gagov H.S., Fusi F., Corsi M., Sgaragli G.P. and Boev K.K. (1999). Calcium current in freshly isolated smooth muscle cells from rat tail artery. XXIX National Congress of the Italian Society of Pharmacology. Florence, Italy, June 20-23.37) Petkov G.V., Gagov H.S., Fusi F., Sgaragli G.P. and Boev K.K. (1999). Effects of t-butyl phenols on calcium current in smooth muscle cells. XXIX National Congress of the Italian Society of Pharmacology. Florence, Italy, June 20-23.38) Palmi M., Tchuisseu Youmbi G., Davey G., Meini A., Benocci A., Fusi F., Frosini M., Sgaragli G.P. and Tipton K.F. (1999). Taurine and mitochondria Ca2+ accumulation. International Taurine Symposium 1999. Taurine and Excitable Tissues. Siena, Italy, August 4-8.39) Sesti C., Frosini M., Palmi M., Valoti M., Fusi F., Bianchi L., Della Corte L. and Sgaragli G.P. (1999). Changes in cerebrospinal fluid composition in conscious rabbit exposed to high ambient temperatures: the possible role of taurine and GABA as cryogens. International Taurine Symposium 1999. Taurine and Excitable Tissues. Siena, Italy, August 4-8.40) Fusi F., Saponara S., Gagov H. and Sgaragli G.P. (1999). The patch-clamp technique: development and uses to investigate Ca2+ currents. Accademia dei Fisiocritici, Siena, Italy, November 24.41) Fusi F., Saponara S., Pessina F., Gorelli B., Vittori L. and Sgaragli G.P. Effetto dei polifenoli del vino sulla contrazione e sulla corrente del calcio nel muscolo vascolare. Convegno "Vino e Salute: aspetti economici, sociali e medici". Siena, Italy, 11 December 2000.42) Fusi F., Saponara S., Pessina F., Gorelli B., Vittori L. and Sgaragli G.P. Effects of wine polyphenols on vascular functions: an electro-mechanic investigation. European Conference. Bioactive Compounds in Plant Foods. Health effects and perspectives for the food industry. Tenerife, Canary Islands, Spain, 26-28 April 2001.43) Fusi F., Saponara S., Gagov H. and Sgaragli G.P. 2,5-Di-t-butyl-1,4-benzohydroquinone (BHQ) inhibition of vascular L-type Ca2+ channel is mediated by superoxide anion. XXX National Congress of the Italian Pharmacological Society. Genoa, Italy, May 30-June 2, 2001.44) Saponara S., Fusi F., Pessina F., Gorelli B., Vittori L. and Sgaragli G.P. Effects of quercetin on vascular smooth muscle. XXX National Congress of the Italian Pharmacological Society. Genoa, Italy, May 30-June 2, 2001.45) Saponara S., Fusi F., Pessina F., Gorelli B., and Sgaragli G. Effects of wine polyphenols on vascular smooth muscle. Dietary phytochemicals and human health. Salamanca, Spain, April 18-20, 2002.46) Valoti M., Ponticelli F., Fontani M., Fusi F., Saponara S., Pessina F. and Sgaragli G.P. Effects of novel antioxidants, phenol derivatives on human erythrocytes under oxidative stress promoted by AAPH. XIII National Congress of the Italian Toxicological Society. Urbino, Italy, January 22-25, 2003.47) Saponara S., Frosini M., Sgaragli G.P. and Fusi F. Interactions between two Ca2+ channel activators, quercetin and BAY K 8644, in vascular smooth muscle. XXXI Congresso Nazionale della Società Italiana di Farmacologia. Trieste, Italy, June 26-29, 2003.48) Fusi F., Saponara S., Pessina F., Gorelli B. and Sgaragli G.P. Flavonoids: a new class of vascular smooth muscle L-type Ca2+ channel modulators. XXXI Congresso Nazionale della Società Italiana di Farmacologia. Trieste, Italy, June 26-29, 2003.49) Saponara S., Kawase M., Shah A., Motohashi N., Molnar J., Ugocsai K., Sgaragli G. and Fusi F. (2004). 3,5-Dibenzoyl-4-(3-phenoxyphenyl)-1,4-dihydro-2,6-dimethylpyridine (DP7) as a new MDR reverter devoid of vascular effects. 1st ISC International Conference on Cancer Therapeutics, Molecular Targets, Pharmacology and Clinical Applications. Florence, Italy, February 19-21, 2004.50) Fusi F., Saponara S. and Sgaragli G.P. (2004). Effects of quercetin and some flavonoids, structurally related to it, on L-type Ca2+ current of rat tail main artery myocytes. "Flavonoidi Chimica, Farmacognosia, Farmacologia ed Impiego Terapeutico". Naples, Italy, April 3, 2004.51) Saponara S., Kawase M., Shah A., Motohashi N., Molnar J., Ugocsai K., Fusi F. and Sgaragli G. (2004). 3,5-Dibenzoyl-4-(3-phenoxyphenyl)-1,4-dihydro-2,6-dimethylpyridine (DP7) as a new MDR reverter devoid of effects on vascular smooth muscle contractility. Giovanni Armenise-Harvard Foundation 8th Annual Symposium on Cancer Biology and Genomics and Post-Genomics. Siena, Italy, May 21-23, 2004.52) Fusi F., Saponara S. and Sgaragli G.P. Effects of quercetin and other structurally related flavonoids on L-type Ca2+ current of rat tail main artery myocytes. European Workshop on Cellular responses to bioactive plant compounds - implications for human health. Budapest, Hungary, September 30-October 2, 2004.53) Fusi F., Saponara S., Kawase M., Shah A., Motohashi N., Molnar J., Ugocsai K. and Sgaragli G. 3,5-Dibenzoyl-4-(3-phenoxyphenyl)-1,4-dihydro-2,6-dimethylpyridine (DP7) as a new multidrug resistance reverting agent devoid of effects on vascular smooth muscle contractility. Pharmacological strategies to overcome multidrug resistance in cancer chemotherapy. Siena, Italy, November 22, 2004.54) Saponara S., Kawase M., Shah A., Motohashi N., Molnar J., Ugocsai K., Sgaragli G. and Fusi F. 3,5-Dibenzoyl-4-(3-phenoxyphenyl)-1,4-dihydro-2,6-dimethylpyridine (DP7) as a new multidrug resistance reverting agent devoid of effects on vascular smooth muscle contractility. International Symposium on Reversal of Multidrug Resistance in Cancer Cells. Szeged, Hungary, December 13, 2004.55) Saponara S., Fusi F., Iozzi D., Lorusso F., Sgaragli G. Mechanism of myricetin stimulation of vascular L-type Ca2+ current. XXXII Congresso Nazionale della Società Italiana di Farmacologia. Naples, Italy, June 1-4, 2005.56) Fusi F., Gelli M., D’Elia P., Saponara S., Molnar J. and Sgaragli G. Vascular effects of new silicon compounds active as resistance modifier against multidrug-resistant cancer cells. Pharmacological strategies to overcome multidrug resistance in cancer chemotherapy. II Annual Symposium. Siena, Italy, November 22, 2005.57) Fusi F. and Saponara S. Vino e salute da un punto di vista molecolare: una relazione complessa. XVI Settimana della Cultura Scientifica. "Vino e Salute". Siena, Italia, 15 marzo 2006.58) Ioan P., Budriesi R., Ugenti M.P., Chiarini A., Carosati E., Cruciani G., Spinelli D., Cosimelli B., Novellino E., Fusi F., Frosini M., Gasparrini F., Stephen P.J. Un Approccio Multidisciplinare per lo Studio di Nuovi Modulatori dei Canali del Ca2+ di tipo-L. Med. Chem. Division of the XXII Congresso Nazionale della Società Chimica Italiana. Florence, Italy, September 10-15, 2006.59) Fusi F., Saponara S., Testai L., Iozzi D., Martinotti E., Martelli A., Chericoni S., Sgaragli G., Calderone V. (+/-)-Naringenin as KCa 1.1 channels opener in vascular smooth muscle cells.Molecular and physiological effects of bioactive food compounds. Wien, Austria, October 11-14, 2006.60) Sgaragli G., Fusi F., Saponara S. Functional interactions between two L-type Ca2+ channel activators, quercetin and Bay K 8644, in rat tail artery myocytes. Molecular and physiological effects of bioactive food compounds. Wien, Austria, October 11-14 2006.61) Alderighi D., Gori M., Sgaragli T., Dragoni S., Frosini M., Valoti M., Saponara S., Fusi F., Kawase M., Shah A., Motohashi N., Molnar J., Sgaragli G. Inhibition of P-gp/ATPase activity of rat small intestine membrane vesicles by the novel, dihydropyridine MDR reverter DP7. Pharmacological strategies to overcome multidrug resistance in cancer chemotherapy. III Annual Symposium. Certosa di Pontignano, Siena, Italy, November 14, 2006.62) Lacava C., Sipos E., H?ller C., Kress H.G., Sgaragli G., Fusi F., Weigl L. Use of 3,5 di-t-butylcatechol (DTCAT) in the diagnosis of malignant hyperthermia (MH). European Malignant Hyperthermia Group 2007 Meeting, Certosa di Pontignano, Siena, Italy, May 20-23, 2007.63) Alderighi D., Sgaragli T., Dragoni S., Frosini M., Valoti M., Saponara S., Fusi F., Shah A., Kawase M., Motohashi N., Molnar J., Sgaragli G. Inhibition of P-gp/ATPase activity of rat small intestine membrane vesicles by the novel, dihydropyridine MDR reverter DP7. XXXIII Congresso Nazionale della Società Italiana di Farmacologia. Cagliari, Italy, June 6-9, 2007.64) Ferrara A., Fusi F., Koorbanally C., Crouch N.R., Mulholland D.A., Sgaragli G. Vascular activity of isolates from the hyacinthaceae of South Africa. XXXIII Congresso Nazionale della Società Italiana di Farmacologia. Cagliari, Italy, June 6-9, 2007.65) D’Elia P., Dragoni S., Valoti M., De Matteis F., Saponara S., Fusi F., Sgaragli G. Inhibition studies of DP7, a novel MDR reverter,on CYP-dependent activities in human and rat liver microsomes. Pharmacological strategies to overcome multidrug resistance in cancer chemotherapy. IV Annual Symposium. Certosa di Pontignano, Siena, Italy, November 19-20, 2007.66) Saponara S., Fusi F., Ricci L., Frosini M., Dragoni S., Valoti M., Valeri A., Pessina F., Sgaragli G. I polifenoli di origine naturale e la salute umana: effetti su rilevanti bersagli farmacologici. Congresso Nazionale: Farmaci Naturali. Attualità e Prospettive Future. Benevento, Italy, March 27-29, 2009.67) Fusi F. (2011). Vascular ion channels as targets of wine polyphenols and their metabolites: a possible explanation for their beneficial health effects. Seminario Scientifico sul bere responsabile nella dieta mediterranea e nello stile di vita italiano. Certosa di Pontignano, Siena, Italy, 10-11 giugno 2011.68) Neri A., Frosini M., Saponara S., Fusi F., Dragoni S., Cacace M., Dei S., Teodori E., Valoti M., Sgaragli G. New approaches for reversing cancer multidrug resistance. La farmacologia oncologica tra innovazione ed evidenza clinica. Siena, Italy, November 30-December 1, 2012.69) Durante M., Neri A., Frosini M., Valoti M., Sgaragli G., Fusi F., Chegaev K., Saponara S. Screening for potential hazard effects from multitarget anthracyclines on vasculature. XXXVI Congresso Nazionale della Società Italiana di Farmacologia. Turin, Italy, October 23-26, 2013.70) Durante M., Cuong N.M., Khanh P.N., Huyen P.T., Ha V.T., Duc H.V., Huong T.T., Tai B.H., Binh N.Q., Sgaragli G.,Fusi F. In vitro vasoactivity of novel natural leads from Vietnamese medicinal plants. XXXVI Congresso Nazionale della Società Italiana di Farmacologia. Turin, Italy, October 23-26, 2013.71) Durante M., Sgaragli G., Huong T.T., Cuong N.M., Fusi F. Vascular L-type Ca2+ channel mediated activity of murrayafoline A from Glycosmis stenocarpa: electrophysiological and molecular docking studies. Convegno Monotematico della Società Italiana Di Farmacologia, Gruppo di Lavoro Farmacognosia. Farmacognosia: nuove opportunità terapeutichedal mondo vegetale. Naples, Italy, June 20-21, 2014.72) Durante M., Frosini M., Fusi F., Maestrini V., Gorelli B., Valoti M., Chegaev K., Saponara S. Screening for potential hazard effects from a multitarget anthracycline on the cardiovascular system. XXXVII Congresso Nazionale della Società Italiana di Farmacologia. Naples, Italy, 27-30 October, 2015.73) Saponara S., Fusi F., Saponara S., Macucci M. Failure effect analysis of patch-clamp electronic instrumentation in electrophysiology experiments. Applications in Electronics Pervading Industry, Environment and Society (ApplePies). Rome, Italy, 15-16 September, 2016.74) Durante M., Fusi F., Spiga O., Trezza A., Frosini M., Floriddia E., Teodori E., Dei S., Saponara S. In vitro and in silico analysis of the vascular effects of asymmetrical N,N-bis(alkanol)amine aryl esters, novel multidrug-resistance reverting agents. XIX SIF Seminar on Pharmacology and Similar Sciences for Phd Students, Fellows, Post Doc and Specialist Trainees. Rimini, Italy, 20-22 September, 2016.75) Saponara S., Macucci M., Fusi F., Saponara S., Groza V. Failure mode and effect analysis of patch-clamp laboratory instrumentation for electrophysiology measurements. 2017 IEEE International Symposium on Medical Measurements and Application. Rochester, MN, USA, 7-10 May, 2017.76) Durante M., Frosini M., Fusi F., Riganti C., Gazzano E., Chegaev K., Saponara S. In vitro cardiovascular toxicity risk assessment of novel H2S-donating anthracycline. XXXVIII Congresso Nazionale della Società Italiana di Farmacologia. Rimini, Italy, 25-28 October, 2017.77) Dreassi E., Pessina F., Marcolongo P., Fiorenzani P., Frosini M., Saponara S., Fusi F., Valoti M., Botta M., Francardi V. Antihypertensive effect of Tenebrio molitor (Coleoptera: Tenebrionidae) defatted larvae in spontaneously hypertensive rats. XI European Congress of Entomology, Naples, Italy, 2-6 July, 2018.78) Durante M., Frosini M., Fusi F., Rolando B., Chegaev K., Saponara S. In vitro assessment of NitDox toxicity towards vasculature. Monothematic Conference Therapeutic Applications of Nitric Oxide in Cancer and Inflammatory-related Disorders, Accademia dei Fisiocritici, Siena, Italy, 4-5 October, 2018.79) Saponara S., Durante M., Frosini M., Gorelli B., Fusi F. Assessment of cardiovascular liabilities of new candidate drugs. First WG1-WG4 meeting of Cost Action CA17104 “New diagnostic and therapeutic tools against multidrug resistant tumours”. Molecular Biotechnology Center, Turin, Italy, 29-31 January, 2019.80) Pessina F., Frosini M., Marcolongo P., Fusi F., Saponara S., Gamberucci A., Valoti M., Giustarini D., Fiorenzani P., Gorelli B., Francardi V., Botta M., Dreassi E. Effects of Tenebrio molitor (Coleoptera: Tenebrionidae) defatted larvae in spontaneously hypertensive rats. Grand Conference of the Académie Des Sciences. Insects: friends, foes and models. Paris, France, 12-14 March 2019.81) Pessina F., Frosini M., Marcolongo P., Fusi F., Saponara S., Gamberucci A., Valoti M., Giustarini D., Fiorenzani P., Gorelli B., Francardi V., Botta M., Dreassi E. Effects of a diet containing defatted mealworms (Tenebrio molitor) in spontaneously hypertensive rats. Nutrients 2019: Nutritional advances in the prevention and management of chronic disease. Barcelona, Spain, 25-27 September 2019.82) Durante M., Carullo G., Sciubba F., Restuccia D., Spizzirria U.G., Ahmedb A., Di Cocco M.E., Aiello F., Fusi F., Saponara S. Vasoactivity of Mantonico and Pecorello grape pomaces on rat aorta rings: an insight into nutraceutical development. XXXIX Congresso Nazionale della Società Italiana di Farmacologia. Florence, Italy, 20-23 November 2019.83) Ahmed A., Tagliafierro S., Conti S., Fusi F., Valoti M. Perivascular adipose tissue modulation of quercetin vasorelaxant effects on rat aorta rings. XXXIX Congresso Nazionale della Società Italiana di Farmacologia. Florence, Italy, 20-23 November 2019.84) Yordanov Y., Aluani D., Kondeva-Burdina M., Tsakovska I., Alov P., Pencheva T., Lessigiarska I., Fruttero R., Fusi F., Tzankova V., Pajeva I., Saponara S. In silico and in vitro toxicological studies on H2S-releasing doxorubicin. COST Action CA17104 ‘STRATAGEM’ Annual Conference, Belgrade, Serbia, 27-28 February 2020.85) Durante M., Frosini M., Fusi F., Chiaino E., Gorelli B., Riganti C., Chegaev K., Saponara S. In vitro vascular toxicity risk assessment of S-Dox. COST Action CA17104 ‘STRATAGEM’ Annual Conference, Belgrade, Serbia, 27-28 February 2020. ................
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