UKMi Q&A xx - SPS
Phosphodiesterase Inhibitors. Nitric oxide (NO), produced in endothelial cells, causes vasodilation through the production of cyclic guanosine 3’-5’ monophosphate (cGMP) in the vascular smooth muscle.37 Overexpressed in the lungs of patients with PAH, phosphodiesterase type-5 (PDE5) is responsible for the breakdown of cGMP. ................
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