VA Drug Class Review: Phosphodiesterase Type 5 Inhibitors ...
can produce an erection. Phosphodiesterase type 5 is the predominant PDE isozyme in penile tissue and is responsible for the metabolism of cGMP. All the PDE5 inhibitors selectively inhibit PDE5, thus preventing the breakdown of cGMP and enhancing or restoring the natural erectile response. ................
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