Physiologic differences between infants, children and adults
Ductus arteriosus usually closes within first 24 hours due to increased oxygen saturation and removal of prostaglandins from circulation. Transitional circulation – PDA doesn’t close, shunting across it may be L>R, R>L or bidirectional – newborn may revert to this under stress such as sepsis, hypoxia, hypercarbia, acidosis, congenital ... ................
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