Hindawi Publishing Corporation



Appendix. Complete dataset of all medications. Shown are the total 75 medications with enough data to be used by at least one group member; seventy-one of the medications were able to be used for the Modified Kroh analysis in this study. Parameters include: DN (dose in person with normal renal function based on package insert), CLESRD (total body clearance in anuric person with ESRD), CLN (total body clearance in person with normal renal function), Aronoff et al. dose (dose given in Aronoff text), CLAKI (total body clearance in anuric person with AKI), SC (sieving coefficient), Danuria (recommended dose in anuric patients based on package insert), and CLNR (nonrenal drug clearance in an individual with normal renal function). Not displayed are the assumed constants: CLCRtot (33ml/min; sum of renal and extracorporeal creatinine clearance in an anuric patient undergoing CRRT), CLCRn (100ml/min; normal creatinine clearance for patient with normal renal function), and QF (33.3ml/min; ultrafiltration rate). Asterisk (*) denotes data was not found.Drug NameDN (mg/day)CLESRD (mL/min)CLN (mL/min)Aronoff et al. Dose (mg/day)CLAKI (mL/min)SC Danuria (mg/day)CLNR (mL/min)Referencesacyclovir80028.00317.0052531.270.6040078.86ADDIN RW.CITE{{30 [NoInformation] 1997; 31 Blum,M.R. 1982; 32 Boulieu,R. 1997; 33 deMiranda,P. 1983; 34 Khajehdehi,P. 2000; 35 Krasny,H.C. 1982; 223 Laskin,O.L. 1982; 36 Leikin,J.B. 1995; 224 Mueller,B.A. 1993}}(19-27)amikacin10502.17100.00525*0.933506.00ADDIN RW.CITE{{335 Armendariz,E. 1990; 333 Blair,D.C. 1982; 334 Kinowski,J.M. 1993; 315 TevaMedicines 2010}}(30-33)amoxicillin150040.00220.25500*0.8050050.75ADDIN RW.CITE{{260 GlaxoSmithKline 2006; 265 Horber,F.F. 1986; 264 Sjovall,J. 1985; 419 Bennett,W.M. 1983}}(37-40)amphotericin B35013.00141.0035092.10.05350121.10ADDIN RW.CITE{{376 AstellasPharmaUS,Inc. 2012; 396 Bekersky,I. 2002; 395 Bellmann,R. 2003; 397 Gussak,H.M. 2001; 398 Janknegt,R. 1992}}(41-45)ampicillin800030.50237.948000*0.72200050.20ADDIN RW.CITE{{419 Bennett,W.M. 1983; 264 Sjovall,J. 1985; 267 Blum,R.A. 1989; 266 Meyers,B.R. 1991; 261 Roerig 2009}}(39,40,46-48)aztreonam600031.21102.812000*0.70200037.50ADDIN RW.CITE{{224 Mueller,B.A. 1993; 70 [NoInformation] 2009; 66 Adamis,G. 2004; 73 elGuinaidy,M.A. 1989; 74 Fillastre,J.P. 1985; 226 Gerig,J.S. 1984; 227 Janicke,D.M. 1985}}(27,52-57)cefazolin30005.1066.604000*0.265002.60ADDIN RW.CITE{{401 Craig,W.A. 1973; 378 GlaxoSmithKline 2004; 402 Kirby,W.M. 1973}}(65-67)cefepime60008.90120.004000230.8050010.00ADDIN RW.CITE{{379 Bristol-MyersSquibb,Inc. 2009; 403 Malone,R.S. 2001; 404 Schmaldienst,S. 2000}}(68-70)cefotaxime500061.80280.902000*0.681500110.50ADDIN RW.CITE{{405 Fillastre,J.P. 1980; 406 Patel,K.B. 1995; 380 Sanofi-AventisU.S.LLC 2007}}(71-73)cefotetan30008.0030.002000*0.1210004.20ADDIN RW.CITE{{381 AstraZenecaPharmaceuticalsLP 2004; 407 Ohkawa,M. 1983; 408 Ward,A. 1985}}(74-76)cefoxitin50006.20279.006000*0.42100058.00ADDIN RW.CITE{{409 Fillastre,J.P. 1978; 410 Ko,H. 1989; 382 Merk&Co.,Inc. 2006}}(77-79)ceftaroline fosamil1200*160.00800*0.8040041.10ADDIN RW.CITE{{318 ForestPharmaceuticals 2011; 342 Laudano,J.B. 2011; 343 Steed,M.E. 2010}}(80-82)ceftazidime40006.80115.00400028.40.8125015.00ADDIN RW.CITE{{383 GlaxoSmithKline 2007; 411 Leroy,A. 1984; 412 Mariat,C. 2006}}(83-85)ceftriaxone150012.3037.70200022.70.11150023.80ADDIN RW.CITE{{413 Cohen,D. 1983; 384 GenetechUSA,Inc. 2010; 414 Kroh,U.F. 1996}}(86-88)cefuroxime sodium45008.24125.0020006.10.9075013.70ADDIN RW.CITE{{415 Davies,S.P. 1991; 385 GlaxoSmithKline 2007; 416 Walstad,R.A. 1983}}(89-91)ciprofloxacin1200151.67583.33400*0.67400216.67ADDIN RW.CITE{{319 BayerHealthcarePharmaceuticals 2011; 344 Malone,R.S. 2001; 345 Shah,A. 1996; 346 Spooner,A.M. 2011; 347 Wallis,S.C. 2001}}(92-96)clindamycin2250*315.001800*0.232250263.03ADDIN RW.CITE{{274 E.Fougera&Co. 2007; 282 Gatti,G. 1993; 281 Gordon,R.C. 1973}}(97-99)daptomycin5003.4011.5428050.162103.87ADDIN RW.CITE{{232 [NoInformation] 2006; 200 Churchwell,M.D. 2006; 199 Dvorchik,B. 2004; 234 Liang,S.H. 2009; 202 Salama,N.N. 2010; 233 Vilay,A.M. 2011}}(108-113)doripenem150028.70253.8975044.50.6750085.17ADDIN RW.CITE{{235 [NoInformation] 2007; 103 Chahine,E.B. 2010; 107 Cirillo,I. 2009; 102 Cirillo,I. 2011; 106 Hidaka,S. 2010; 109 Tanoue,K. 2011}}(118-123)ertapenem1000*30.00100019.30.2150016.10ADDIN RW.CITE{{236 [NoInformation] 2011; 237 Burkhardt,O. 2009; 238 Eyler,R.Fl 2011; 113 Majumdar,A.K. 2002}}(128-131)fluconazole400*18.804007.80.891005.60ADDIN RW.CITE{{399 Brammer,K.W. 1990; 400 Muhl,E. 2000; 377 Pfizer,Inc. 2011}}(138-140)foscavir630017.50148.052100*0.85*11.93ADDIN RW.CITE{{44 [NoInformation] 2006; 110 Aweeka,F.T. 1999; 111 Jayasekara,D. 1999; 239 Noormohamed,F.H. 1997; 46 Noormohamed,F.H. 1998; 47 Raffi,F. 1993; 48 Sjovall,J. 1989}}(141-147)ganciclovir3003.50246.4087.510.10.8518.7544.12ADDIN RW.CITE{{59 [NoInformation] 2009; 60 Bastien,O. 1994; 61 Combarnous,F. 1994; 62 Lake,K.D. 1988; 63 Sommadossi,J.P. 1988}}(148-152)gentamicin2706.0372.001209.160.83306.00ADDIN RW.CITE{{349 Al-Homrany,M.A. 2009; 350 Bickley,S.K. 1988; 351 Dager,W.E. 2006; 322 Hospira 2004; 352 Roberts,J.A. 2010; 353 Thomson,A.H. 1991}}(153-158)imipenem275052.50371.45200091.951.20500128.10ADDIN RW.CITE{{240 [NoInformation] 2011; 242 Adamis,G. 2004; 241 Gibson,T.P. 1985; 99 Hashimoto,Satoru 1997; 100 Mueller,B.A. 1993; 243 Tegeder,I. 1997}}(162-167)levofloxacin75037.00158.0025051.160.6425059.00ADDIN RW.CITE{{361 Czock,D. 2006; 362 Guenter,S.G. 2002; 358 Hansen,E. 2001; 359 Malone,R.S. 2001; 325 Ortho-McNeilPharmaceuticals 2011; 363 Sowinski,K.M. 2003; 360 Traunmuller,F. 2001}}(172-178)linezolid120076.60118.00120061.60.67120067.17ADDIN RW.CITE{{246 [NoInformation] 2008; 79 Brier,M.E. 2003; 81 Dryden,M.S. 2011; 78 Fiaccadori,E. 2004; 80 Pea,F. 2004; 82 Stalker,D.J. 2003}}(184-189)meropenem300025.40255.00300082.3870.88150061.70ADDIN RW.CITE{{247 [NoInformation] 2010; 69 Giles,L.J. 2000; 85 Isla,A. 2005; 89 Leroy,A. 1992; 86 Tegeder,I. 1999; 87 Thalhammer,F. 1998}}(193-198)moxifloxacin400151.67200.00400256.670.82400156.60ADDIN RW.CITE{{361 Czock,D. 2006; 326 BayerHealthcarePharmaceuticals 2011; 364 Fuhrmann,V. 2004; 365 Ittner,K.P. 2005; 366 Stass,H. 2002}}(172,217-220)nafcillin6000*628.006000*0.109000439.60ADDIN RW.CITE{{262 APPPharmaceuticals 2011; 268 Rudnick,M. 1976}}(221,222)oseltamivir150*341.1015033.30.58300.00ADDIN RW.CITE{{49 [NoInformation] 2011; 50 Ariano,R.E. 2010; 51 Beigi,RichardH. 2011; 53 Dutkowski,R. 2010; 54 He,G. 1999; 55 McNicholl,I.R. 2001}}(223-228)piperacillin1600047.83183.331200044.0250.70800058.67ADDIN RW.CITE{{271 Arzuaga,A. 2005; 270 Bulitta,J.B. 2010; 272 Mueller,S.C. 2002; 269 Thompson,M.I. 1981; 263 WyethPharmaceuticals,Inc. 2008}}(240-244)rifampin600*198.00600*0.20600138.00ADDIN RW.CITE{{386 Sanofi-AventisU.S.LLC 2010}}(256)sulbactam400045.30231.081000*0.62100048.11ADDIN RW.CITE{{261 Roerig 2009; 266 Meyers,B.R. 1991; 267 Blum,R.A. 1989}}(46-48)tazobactam2000*155.90150026.60.70100031.18ADDIN RW.CITE{{263 WyethPharmaceuticals,Inc. 2008; 271 Arzuaga,A. 2005; 272 Mueller,S.C. 2002; 275 Shea,K.M. 2009; 276 Wise,R. 1991}}(240,242,244,265,266)telavancin7008.1714.58500*0.283504.67ADDIN RW.CITE{{92 [NoInformation] 2009; 255 Duchin,K. 2005; 256 Gotfried,M.H. 2008; 96 Patel,J.H. 2009; 95 Shaw,J.P. 2005; 94 Wong,S.L. 2008}}(267-272)tigecycline100275.34344.17100*0.20100288.08ADDIN RW.CITE{{257 [NoInformation] 2007; 259 Ponticelli,C. 2008; 116 Rello,J. 2005; 258 Troy,S.M. 2003}}(273-276)tobramycin2703.5070.0012014.51.00122.50.00ADDIN RW.CITE{{374 Aronoff,G.R. 1990; 331 Hospira 2007; 375 Joos,B. 1996; 351 Dager,W.E. 2006}}(155,277-279)trimethoprim1050*100.00700*0.5635036.00ADDIN RW.CITE{{387 KingPharmaceuticals,Inc. 2006}}(282)vancomycin20006.0767.67100026.30.4512511.67ADDIN RW.CITE{{280 Boereboom,F.T. 1999; 279 Kielstein,J.T. 2006; 278 Macias,W.L. 1991; 277 Tan,C.C. 1990; 273 ViroPharmaIncorporated 2005}}(283-287) ................
................

In order to avoid copyright disputes, this page is only a partial summary.

Google Online Preview   Download