Drugs Which Can Affect Near Vision: A Useful List
Drugs Which Can Affect
Near Vision: A Useful List
Joanne L. Smith B.Sc., Ph.Phm.*
J. Raymond Buncic, M.D., F.R.C.S.(C)t
ABSTRACT
This paper documents a list of drugs that cause problems with near vision, by virtue of effects on accommodation, occasionally
refractive error and diplopia. It is meant as a reference aid to the clinician when confronted with problems of focusing on near objects
or print.
There are many drugs that have been reported to interfere with near or reading vision, producing blurring, decreased accommodation
and diplopia. This paper lists the drugs that have been reported in the literature to produce symptoms which interfere with near vision.
Case reports for the listed drugs vary greatly from many to few. The drugs have been divided into the following categories: those
causing (A) blurring at near, (B) diplopia and (C) induced myopia. Those drugs which only rarely cause these symptoms have been
omitted.
From the Departments of Pharmacy* and Ophthalmologyt, The Hospital For Sick Children, Toronto, Ontario, Canada
Requests for reprints should be addressed to: Dr. J. Raymond Buncic, Department of Ophthalmology, The Hospital For Sick Children, 555 University Ave., Toronto, Ontario, Canada M5G lX8
TABLE 1
DRUGS COMMONLY CAUSING DIFFICULTY WITH FOCUSING AT NEAR OR BLURRED VISION.
DRUG
Antipsychotics
Chlorpromazine
Clozapine
Fluphenazine
Haloperidol
Loxapine
Perphenazine
Pimozide
Risperidone
Thioridazine
Thiothixene
Trifluoperazine
Antidepressants
Bupropion
Doxepin
MAOls, for example:
Phenelzine
Tranylcypromine
Maprotiline
Nefazodone
SSRls, for example:
Fluoxetine
Fluvoxamine
Paroxetine
Sertraline
Tricyclic Antidepressants,
for example:
Amitriptyline
Clomipramine
Desipramine
Imipramine
Nortriptyline
Trimipramine
INCIDENCE
REFERENCE
14-23
5
1.2-4.3
6.8-16
5.3-15%
20
8
8,14
8
8
12,14
8
8
11
8
8
8
8,9
11
8
1.5-17%)
9%(2-10%)
4%
9%
8
8
11
11
3-4.5%
6.3%
4%
4%
8,11
14
11
11
7.4-17.8
20
1-2%, >/= 10%
0.6-18
20
4-10
7.5-35%
18-20% adults
2-6
1.2-17%
5.5%
6%
8
8
8
8
8
8
Venlafaxine
Anticholinergics
Atropine
Belladonna
Benztropine
Dicyclomine
Donepezil
Hyoscyamine
Propantheline
Scopolamine
Trihexyphenidyl
Other Drugs
Amiodarone
Buspirone
Calcium channel blockers
Carbamazepine
Chloroquine
Chlorpheniramine
Clomiphene
Cyclophosphamide
Cytarabine
Digoxin
Fludarabine
Gabapentin
Guanethedine
Hydroxychloroquine
Indinavir
Lamotrigine
Lithium
Mexilitine
Piroxicam
Quinidine
Ritonavir
Trimethadione
Zidovudine
6%
20%
1-2%
11
12
12
8
12
14
14
12
12,14
12
(high doses)
2%
(high doses)
-1%
-5-10%
4.2% (amblyopia)
17%
................
................
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