3D STATISTICAL ANALYSIS



GENETIC INFLUENCES ON BRAIN STRUCTURE

1Paul Thompson PhD, 2Tyrone D. Cannon PhD, 1Katherine L. Narr,

2Theo van Erp, 3Veli-Pekka Poutanen, 4Matti Huttunen MD PhD, 4Jouko Lönnqvist MD PhD,

3Carl-Gustaf Standertskjöld-Nordenstam MD, 5Jaakko Kaprio MD PhD,

1Mohammad Khaledy, 1Rajneesh Dail, 1Chris I. Zoumalan, 1Arthur W. Toga PhD

1Laboratory of Neuro Imaging and Brain Mapping Division,

Department of Neurology, UCLA School of Medicine

2Departments of Psychology, Psychiatry, and Human Genetics,

UCLA School of Medicine

3Department of Radiology, University of Helsinki

4Department of Mental Health and Alcohol Research,

National Public Health Institute of Finland

5Department of Public Health, Universities of Helsinki and Oulu

Submitted: June 4, 2001

Revised: August 8, 2001

2nd Revision: September 15, 2001

3rd Revised Version (with additional revisions): October 10, 2001

4th Revision with Editorial Changes: October 18, 2001

Word Count: Main text: 3297; Figure Legends: 307; 3 figures, 1 table

Estimated Number of Journal Pages, with Figures: 4

Please address correspondence to:

Dr. Paul Thompson

(Rm. 4238, Reed Neurological Research Center)

Laboratory of Neuro Imaging, Dept. of Neurology, UCLA School of Medicine

710 Westwood Plaza, Los Angeles, CA 90095-1769

Phone: (310) 206-2101 Fax: (310) 206-5518 E-mail: thompson@loni.ucla.edu

GENETIC INFLUENCES ON BRAIN STRUCTURE

cPaul Thompson PhD, 2Tyrone D. Cannon PhD, 1Katherine L. Narr, 2Theo van Erp,

3Veli-Pekka Poutanen, 4Matti Huttunen MD PhD, 4Jouko Lönnqvist MD PhD,

3Carl-Gustaf Standertskjöld-Nordenstam MD, 5Jaakko Kaprio MD PhD,

1Mohammad Khaledy, 1Rajneesh Dail, 1Chris I. Zoumalan, 1Arthur W. Toga PhD

1Laboratory of Neuro Imaging, Brain Mapping Division,

Department of Neurology, UCLA School of Medicine

2Departments of Psychology, Psychiatry, and Human Genetics, UCLA School of Medicine

3Department of Radiology, University of Helsinki

4Department of Mental Health and Alcohol Research, National Public Health Institute of Finland

5Department of Public Health, Universities of Helsinki and Oulu

We report the first, detailed, 3-dimensional maps revealing how brain structure is influenced by individual genetic differences. A genetic continuum was detected, in which brain structure was increasingly similar in subjects with increasing genetic affinity. Genetic factors significantly influenced cortical structure in Broca’s and Wernicke’s language areas, as well as frontal brain regions (r2MZ > 0.8, p ................
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