CHAPTER 40 The Mechanism of Protein Synthesis
CHAPTER 40
The Mechanism of Protein Synthesis
Problems: 2,3,6,7,9,13,14,15,18,19,20
? Initiation: Locating the start codon.
? Elongation: Reading the codons (5'3') and synthesizing protein aminocarboxyl.
? Termination: Recognizing terminal codon and releasing protein.
Prokaryotes and Eukaryotes
40:1 Decoding the Information in mRNA
Exit Peptidyl Aminoacyl
Initiation
Start codon (also GUG, Val) Shine-Delgarno Sequence
Start: 1. Pairing of 16S
rRNA with SD of mRNA (a UTR). 2. Pairing of initiator tRNA with start codon.
Initiator tRNAf
Two different tRNA's that carry Met; tRNAf and tRNAm.
One Synthetase adds Met to both tRNAf and tRNAm.
A specific transformylase only formylates Met-tRNAf.
Initiation
Initiation factors, IF1, IF2 and IF3.
IF1 and IF3 prevent premature assembly of the 70S ribosome.
IF2 binds to fMet-tRNAf and mRNA at AUG codon.
The fMet-tRNAf in the fully assembled ribosome is in the P-site.
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