QMC Adult Critical Care Induction Manual for Junior ...
Propofol should not be infused for longer than 5 days without providing a drug holiday to safely replace estimated or measured urine zinc losses. In patients who are predisposed to zinc deficiency, such as those with burns, diarrhea, and/or major sepsis, the need for supplemental zinc should be considered during prolonged therapy with Propofol. ................
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