Severe Traumtic Brain Injury

High dose propofol infusions (>83 mcg/kg/min for greater than 24 hours) have been associated with fatal acidosis, rhabdomyolysis, and refractory arrhythmias (known as “Propofol Infusion Syndrome”) (35). In general, doses of less than 50 mcg/kg/min are both effective and safe. ................
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