University of Manchester
Title: Does cognitive behavioural therapy for insomnia improve cognitive performance? A systematic review and narrative synthesis Authors: V. Herbert1 MSc, ClinPsyD, S.D. Kyle2 PhD, & D. Pratt1 PhD, ClinPsyDDivision of Psychology and Mental Health, School of Health Sciences, University of Manchester, UKSleep and Circadian Neuroscience Institute (SCNi), Nuffield Department of Clinical Neurosciences, University of Oxford, UKCorrespondence to:Daniel Pratt, Division of Psychology and Mental Health, School of Health Sciences, University of Manchester, Zochonis Building, Brunswick Street, Manchester M13 9PL, U.K. email: daniel.pratt@manchester.ac.uk Simon D. Kyle, Sleep and Circadian Neuroscience Institute, Nuffield Department of Clinical Neurosciences, University of Oxford, Sir William Dunn School of Pathology, South Parks Road, Oxford, OX1 3RE. email: simon.kyle@ndcn.ox.ac.ukWord count: 8310Acknowledgements: The authors would like to thank Sara Bardsley for her assistance with quality assessment.Conflict of interest statement: The authors report no conflicts of interest relating to material presented in this review. SummaryIndividuals with insomnia report difficulties pertaining to their cognitive functioning. Cognitive behavioural therapy for insomnia (CBT-I) is associated with robust, long-term improvements in sleep parameters, however less is known about the impact of CBT-I on the daytime correlates of the disorder. A systematic review and narrative synthesis was conducted in order to summarise and evaluate the evidence regarding the impact of CBT-I on cognitive functioning. Reference databases were searched and studies were included if they assessed cognitive performance as an outcome of CBT-I, using either self-report questionnaires or cognitive tests. Eighteen studies met inclusion criteria, comprising 923 individuals with insomnia symptoms. The standardised mean difference was calculated at post-intervention and follow-up. We found preliminary evidence for small to moderate effects of CBT-I on subjective measures of cognitive functioning. Few of the effects were statistically significant, likely due to small sample sizes and limited statistical power. There is a lack of evidence with regards to the impact of CBT-I on objective cognitive performance, primarily due to the small number of studies that administered an objective measure (n=4). We conclude that adequately powered randomised controlled trials (RCT), utilising both subjective and objective measures of cognitive functioning are required. Keywords: Insomnia, cognitive behavioural therapy, CBT-I, cognitive functioning, narrative synthesisAbbreviationsAFIattentional function indexANT-Iattentional network test – interactions taskATautogenic trainingBBTIbrief behavioural treatment for insomniaBPTbehavioural placebo treatmentCBT-Icognitive behavioural therapy for insomniaCBT-I ADcognitive behavioural therapy for insomnia in recovering alcohol dependent patientsCBTI-Phonetelephone delivered cognitive behavioural therapy for insomnia CTcognitive therapyDSM-IVdiagnostic and statistical manual of mental disorders, fourth editionDSM-Vdiagnostic and statistical manual of mental disorders, fifth editionEEGelectroencephalogramICinformation controlIPCinformation pamphlet controlISIinsomnia severity indexLM1logical memory test immediate recallLM2logical memory test delayed recallmCBTminimal CBT-IMFI-20multidimensional fatigue inventoryMFSI-SFmultidimensional fatigue symptom inventory – short formMMSEmini-mental state examinationNRnot reportedNRTnon-randomised trialPMRprogressive muscle relaxationPSGpolysomnographyQRquality ratingRCTrandomised controlled trialRLrelaxationRTreaction timePSQIPittsburgh sleep quality indexRCTrandomised controlled trialSATswitching Attention TestSCstimulus controlSHsleep hygieneSHUTisleep healthy using the internetSMDstandardised mean differenceSRsleep restrictionSRTsleep restriction therapyTONItest of nonverbal intelligenceTSTtotal sleep timeUSAUnited States of AmericaUTuncontrolled trialWASOwake time after sleep onsetWLCwait list controlWMS-CRWechsler memory scale – Chinese revisionIntroductionInsomnia is characterised by persistent difficulties with sleep initiation and/or maintenance. Insomnia is recognised as a 24-hour disorder, with impairments in daytime functioning and distress attributed to poor sleep being one of the core diagnostic criteria PEVuZE5vdGU+PENpdGU+PFllYXI+MjAwNTwvWWVhcj48UmVjTnVtPjM3PC9SZWNOdW0+PERpc3Bs
YXlUZXh0PigxLCAyKTwvRGlzcGxheVRleHQ+PHJlY29yZD48cmVjLW51bWJlcj4zNzwvcmVjLW51
bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9IjVwcndlNXNhMXN6MnNwZWVm
d3I1dHgwb3hkdzlzenp4cGFzciI+Mzc8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFt
ZT0iQm9vayI+NjwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48L2NvbnRyaWJ1dG9ycz48dGl0bGVz
Pjx0aXRsZT5UaGUgaW50ZXJuYXRpb25hbCBjbGFzc2lmaWNhdGlvbiBvZiBzbGVlcCBkaXNvcmRl
cnMgOiBkaWFnbm9zdGljICZhbXA7IGNvZGluZyBtYW51YWw8L3RpdGxlPjwvdGl0bGVzPjxlZGl0
aW9uPjJuZCBlZC48L2VkaXRpb24+PGRhdGVzPjx5ZWFyPjIwMDU8L3llYXI+PC9kYXRlcz48cHVi
LWxvY2F0aW9uPldlc3RjaGVzdGVyLCBJbGwuPC9wdWItbG9jYXRpb24+PHB1Ymxpc2hlcj5BbWVy
aWNhbiBBY2FkZW15IG9mIFNsZWVwIE1lZGljaW5lPC9wdWJsaXNoZXI+PGlzYm4+MDk2NTcyMjAy
MyAocGJrLik8L2lzYm4+PGNhbGwtbnVtPkJyaXRpc2ggTGlicmFyeSBEU0MgbTA2Ly4zNDU5Njwv
Y2FsbC1udW0+PHVybHM+PC91cmxzPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPkVkaW5n
ZXI8L0F1dGhvcj48WWVhcj4yMDA0PC9ZZWFyPjxSZWNOdW0+MTM0PC9SZWNOdW0+PHJlY29yZD48
cmVjLW51bWJlcj4xMzQ8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRi
LWlkPSI1cHJ3ZTVzYTFzejJzcGVlZndyNXR4MG94ZHc5c3p6eHBhc3IiPjEzNDwva2V5PjwvZm9y
ZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48
Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+RWRpbmdlciwgSi4gRC48L2F1dGhvcj48YXV0
aG9yPkJvbm5ldCwgTS4gSC48L2F1dGhvcj48YXV0aG9yPkJvb3R6aW4sIFIuIFIuPC9hdXRob3I+
PGF1dGhvcj5Eb2docmFtamksIEsuPC9hdXRob3I+PGF1dGhvcj5Eb3JzZXksIEMuIE0uPC9hdXRo
b3I+PGF1dGhvcj5Fc3BpZSwgQy4gQS48L2F1dGhvcj48YXV0aG9yPkphbWllc29uLCBBLiBPLjwv
YXV0aG9yPjxhdXRob3I+TWNDYWxsLCBXLiBWLjwvYXV0aG9yPjxhdXRob3I+TW9yaW4sIEMuIE0u
PC9hdXRob3I+PGF1dGhvcj5TdGVwYW5za2ksIEUuIEouPC9hdXRob3I+PC9hdXRob3JzPjwvY29u
dHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+VkEgTWVkaWNhbCBDZW50ZXIsIER1cmhhbSwgTkMsIFVT
QS48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5EZXJpdmF0aW9uIG9mIHJlc2VhcmNoIGRp
YWdub3N0aWMgY3JpdGVyaWEgZm9yIGluc29tbmlhOiByZXBvcnQgb2YgYW4gQW1lcmljYW4gQWNh
ZGVteSBvZiBTbGVlcCBNZWRpY2luZSBXb3JrIEdyb3VwPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxl
PlNsZWVwPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5TbGVlcDwvYWx0LXRpdGxlPjwvdGl0
bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPlNsZWVwPC9mdWxsLXRpdGxlPjxhYmJyLTE+U2xl
ZXA8L2FiYnItMT48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPlNsZWVw
PC9mdWxsLXRpdGxlPjxhYmJyLTE+U2xlZXA8L2FiYnItMT48L2FsdC1wZXJpb2RpY2FsPjxwYWdl
cz4xNTY3LTk2PC9wYWdlcz48dm9sdW1lPjI3PC92b2x1bWU+PG51bWJlcj44PC9udW1iZXI+PGVk
aXRpb24+MjAwNS8wMi8wMzwvZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+RGlhZ25vc3RpYyBh
bmQgU3RhdGlzdGljYWwgTWFudWFsIG9mIE1lbnRhbCBEaXNvcmRlcnM8L2tleXdvcmQ+PGtleXdv
cmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPlJlZmVyZW5jZSBWYWx1ZXM8L2tleXdvcmQ+PGtl
eXdvcmQ+UmVwcm9kdWNpYmlsaXR5IG9mIFJlc3VsdHM8L2tleXdvcmQ+PGtleXdvcmQ+U2xlZXAg
SW5pdGlhdGlvbiBhbmQgTWFpbnRlbmFuY2UgRGlzb3JkZXJzL2NsYXNzaWZpY2F0aW9uLypkaWFn
bm9zaXM8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAwNDwveWVhcj48cHViLWRh
dGVzPjxkYXRlPkRlYyAxNTwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjAxNjEtODEw
NSAoUHJpbnQpJiN4RDswMTYxLTgxMDUgKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjE1
NjgzMTQ5PC9hY2Nlc3Npb24tbnVtPjx3b3JrLXR5cGU+Q29uc2Vuc3VzIERldmVsb3BtZW50IENv
bmZlcmVuY2UmI3hEO1Jlc2VhcmNoIFN1cHBvcnQsIE5vbi1VLlMuIEdvdiZhcG9zO3QmI3hEO1Jl
dmlldzwvd29yay10eXBlPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5jYmku
bmxtLm5paC5nb3YvcHVibWVkLzE1NjgzMTQ5PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxs
YW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+AG==
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PFllYXI+MjAwNTwvWWVhcj48UmVjTnVtPjM3PC9SZWNOdW0+PERpc3Bs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==
ADDIN EN.CITE.DATA (1, 2). Traditionally considered as a secondary symptom, there is now evidence that insomnia is involved in the aetiology and maintenance of psychopathology PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CYWdsaW9uaTwvQXV0aG9yPjxZZWFyPjIwMTE8L1llYXI+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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CYWdsaW9uaTwvQXV0aG9yPjxZZWFyPjIwMTE8L1llYXI+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ADDIN EN.CITE.DATA (3) and is an independent risk factor for the development of cardiovascular disease ADDIN EN.CITE <EndNote><Cite><Author>Javaheri</Author><Year>2017</Year><RecNum>669</RecNum><DisplayText>(4)</DisplayText><record><rec-number>669</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr">669</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Javaheri, S.</author><author>Redline, S.</author></authors></contributors><auth-address>Brigham and Women's Hospital, Boston, MA. Electronic address: sjavaheri@.
Brigham and Women's Hospital, Boston, MA; Beth Israel Deaconess Medical Center, Boston, MA.</auth-address><titles><title>Insomnia and risk of cardiovascular disease</title><secondary-title>Chest</secondary-title><alt-title>Chest</alt-title></titles><edition>2017/02/06</edition><dates><year>2017</year><pub-dates><date>Jan 30</date></pub-dates></dates><isbn>1931-3543 (Electronic)
0012-3692 (Linking)</isbn><accession-num>28153671</accession-num><work-type>Review</work-type><urls><related-urls><url>;(4) and diabetes PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bbm90aGFpc2ludGF3ZWU8L0F1dGhvcj48WWVhcj4yMDE2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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bbm90aGFpc2ludGF3ZWU8L0F1dGhvcj48WWVhcj4yMDE2
PC9ZZWFyPjxSZWNOdW0+Njc2PC9SZWNOdW0+PERpc3BsYXlUZXh0Pig1KTwvRGlzcGxheVRleHQ+
PHJlY29yZD48cmVjLW51bWJlcj42NzY8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFw
cD0iRU4iIGRiLWlkPSI1cHJ3ZTVzYTFzejJzcGVlZndyNXR4MG94ZHc5c3p6eHBhc3IiPjY3Njwv
a2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9y
ZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+QW5vdGhhaXNpbnRhd2VlLCBU
LjwvYXV0aG9yPjxhdXRob3I+UmV1dHJha3VsLCBTLjwvYXV0aG9yPjxhdXRob3I+VmFuIENhdXRl
ciwgRS48L2F1dGhvcj48YXV0aG9yPlRoYWtraW5zdGlhbiwgQS48L2F1dGhvcj48L2F1dGhvcnM+
PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5EZXBhcnRtZW50IG9mIEZhbWlseSBNZWRpY2lu
ZSwgUmFtYXRoaWJvZGkgSG9zcGl0YWwsIE1haGlkb2wgVW5pdmVyc2l0eSwgQmFuZ2tvaywgVGhh
aWxhbmQ7IFNlY3Rpb24gZm9yIENsaW5pY2FsIEVwaWRlbWlvbG9neSBhbmQgQmlvc3RhdGlzdGlj
cywgUmFtYXRoaWJvZGkgSG9zcGl0YWwsIE1haGlkb2wgVW5pdmVyc2l0eSwgQmFuZ2tvaywgVGhh
aWxhbmQuJiN4RDtEaXZpc2lvbiBvZiBFbmRvY3Jpbm9sb2d5IGFuZCBNZXRhYm9saXNtLCBEZXBh
cnRtZW50IG9mIE1lZGljaW5lLCBSYW1hdGhpYm9kaSBIb3NwaXRhbCwgTWFoaWRvbCBVbml2ZXJz
aXR5LCBCYW5na29rLCBUaGFpbGFuZC4gRWxlY3Ryb25pYyBhZGRyZXNzOiBzcmV1dHJhazEwODAw
QGdtYWlsLmNvbS4mI3hEO1NlY3Rpb24gb2YgQWR1bHQgYW5kIFBlZGlhdHJpYyBFbmRvY3Jpbm9s
b2d5LCBEaWFiZXRlcywgYW5kIE1ldGFib2xpc20sIGFuZCBTbGVlcCwgTWV0YWJvbGlzbSBhbmQg
SGVhbHRoIENlbnRlciwgRGVwYXJ0bWVudCBvZiBNZWRpY2luZSwgVGhlIFVuaXZlcnNpdHkgb2Yg
Q2hpY2FnbywgQ2hpY2FnbywgSUwsIFVTQS4mI3hEO1NlY3Rpb24gZm9yIENsaW5pY2FsIEVwaWRl
bWlvbG9neSBhbmQgQmlvc3RhdGlzdGljcywgUmFtYXRoaWJvZGkgSG9zcGl0YWwsIE1haGlkb2wg
VW5pdmVyc2l0eSwgQmFuZ2tvaywgVGhhaWxhbmQuPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0
bGU+U2xlZXAgZGlzdHVyYmFuY2VzIGNvbXBhcmVkIHRvIHRyYWRpdGlvbmFsIHJpc2sgZmFjdG9y
cyBmb3IgZGlhYmV0ZXMgZGV2ZWxvcG1lbnQ6IFN5c3RlbWF0aWMgcmV2aWV3IGFuZCBtZXRhLWFu
YWx5c2lzPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPlNsZWVwIE1lZCBSZXY8L3NlY29uZGFyeS10
aXRsZT48YWx0LXRpdGxlPlNsZWVwIG1lZGljaW5lIHJldmlld3M8L2FsdC10aXRsZT48L3RpdGxl
cz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5TbGVlcCBNZWQgUmV2PC9mdWxsLXRpdGxlPjxhYmJy
LTE+U2xlZXAgbWVkaWNpbmUgcmV2aWV3czwvYWJici0xPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlv
ZGljYWw+PGZ1bGwtdGl0bGU+U2xlZXAgTWVkIFJldjwvZnVsbC10aXRsZT48YWJici0xPlNsZWVw
IG1lZGljaW5lIHJldmlld3M8L2FiYnItMT48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz4xMS0yNDwv
cGFnZXM+PHZvbHVtZT4zMDwvdm9sdW1lPjxlZGl0aW9uPjIwMTUvMTIvMjI8L2VkaXRpb24+PGRh
dGVzPjx5ZWFyPjIwMTY8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5EZWM8L2RhdGU+PC9wdWItZGF0
ZXM+PC9kYXRlcz48aXNibj4xNTMyLTI5NTUgKEVsZWN0cm9uaWMpJiN4RDsxMDg3LTA3OTIgKExp
bmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjI2Njg3Mjc5PC9hY2Nlc3Npb24tbnVtPjx3b3Jr
LXR5cGU+UmV2aWV3PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93
d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMjY2ODcyNzk8L3VybD48L3JlbGF0ZWQtdXJscz48
L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEwMTYvai5zbXJ2LjIwMTUuMTAuMDAy
PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29y
ZD48L0NpdGU+PC9FbmROb3RlPn==
ADDIN EN.CITE.DATA (5) . This has led to an acknowledgement of the need for attention to and treatment of insomnia, regardless of the co-occurring presence of mental or physical health problems PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5UYW5nPC9BdXRob3I+PFllYXI+MjAwNjwvWWVhcj48UmVj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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5UYW5nPC9BdXRob3I+PFllYXI+MjAwNjwvWWVhcj48UmVj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ADDIN EN.CITE.DATA (6, 7). Impairments in cognitive abilities are among the most commonly reported daytime symptoms of insomnia ADDIN EN.CITE <EndNote><Cite><Author>Roth</Author><Year>1999</Year><RecNum>130</RecNum><DisplayText>(8)</DisplayText><record><rec-number>130</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr">130</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Roth, T.</author><author>Ancoli-Israel, S.</author></authors></contributors><auth-address>National Sleep Foundation.</auth-address><titles><title>Daytime consequences and correlates of insomnia in the United States: results of the 1991 National Sleep Foundation Survey. II</title><secondary-title>Sleep</secondary-title><alt-title>Sleep</alt-title></titles><periodical><full-title>Sleep</full-title><abbr-1>Sleep</abbr-1></periodical><alt-periodical><full-title>Sleep</full-title><abbr-1>Sleep</abbr-1></alt-periodical><pages>S354-8</pages><volume>22 Suppl 2</volume><edition>1999/07/08</edition><keywords><keyword>Accidents, Traffic</keyword><keyword>Adolescent</keyword><keyword>Adult</keyword><keyword>Automobile Driving</keyword><keyword>Chronic Disease</keyword><keyword>Circadian Rhythm/*physiology</keyword><keyword>*Health Surveys</keyword><keyword>Humans</keyword><keyword>Memory Disorders/diagnosis/etiology</keyword><keyword>Middle Aged</keyword><keyword>Quality of Life</keyword><keyword>Severity of Illness Index</keyword><keyword>Sleep Initiation and Maintenance Disorders/complications/diagnosis/*epidemiology</keyword><keyword>Time Factors</keyword><keyword>United States/epidemiology</keyword><keyword>Wakefulness</keyword></keywords><dates><year>1999</year><pub-dates><date>May 1</date></pub-dates></dates><isbn>0161-8105 (Print)
0161-8105 (Linking)</isbn><accession-num>10394607</accession-num><work-type>Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.</work-type><urls><related-urls><url>;(8). Individuals with insomnia describe deficits in attention, concentration and memory which impact on decision making, social functioning and performance at work PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MaW50b248L0F1dGhvcj48WWVhcj4yMDAwPC9ZZWFyPjxS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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MaW50b248L0F1dGhvcj48WWVhcj4yMDAwPC9ZZWFyPjxS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ADDIN EN.CITE.DATA (9, 10) and leave individuals with insomnia feeling as though they are “struggling through the day” ADDIN EN.CITE <EndNote><Cite><Author>Kyle</Author><Year>2010</Year><RecNum>140</RecNum><DisplayText>(11)</DisplayText><record><rec-number>140</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr">140</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Kyle, S. D.</author><author>Espie, C. A.</author><author>Morgan, K.</author></authors></contributors><auth-address>Faculty of Medicine, University of Glasgow Sleep Centre, Sackler Institute of Psychobiological Research, University of Glasgow, Scotland, UK. s.d.kyle@clinmed.gla.ac.uk</auth-address><titles><title>"...Not just a minor thing, it is something major, which stops you from functioning daily": quality of life and daytime functioning in insomnia</title><secondary-title>Behav Sleep Med</secondary-title><alt-title>Behavioral sleep medicine</alt-title></titles><periodical><full-title>Behav Sleep Med</full-title><abbr-1>Behavioral sleep medicine</abbr-1></periodical><alt-periodical><full-title>Behav Sleep Med</full-title><abbr-1>Behavioral sleep medicine</abbr-1></alt-periodical><pages>123-40</pages><volume>8</volume><number>3</number><edition>2010/06/29</edition><keywords><keyword>Adult</keyword><keyword>Behavioral Symptoms/*complications</keyword><keyword>Female</keyword><keyword>Focus Groups</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Medical Records</keyword><keyword>Middle Aged</keyword><keyword>Qualitative Research</keyword><keyword>Quality of Life/*psychology</keyword><keyword>Sleep Initiation and Maintenance Disorders/complications/*psychology</keyword></keywords><dates><year>2010</year></dates><isbn>1540-2010 (Electronic)
1540-2002 (Linking)</isbn><accession-num>20582756</accession-num><urls><related-urls><url>;(11). Interestingly, subjective reports of cognitive deficits have not been consistently corroborated by objective measurements and a body of research assessing cognitive performance in people with insomnia compared to normal sleepers is marked by discrepant findings PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TaGVrbGV0b248L0F1dGhvcj48WWVhcj4yMDEwPC9ZZWFy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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TaGVrbGV0b248L0F1dGhvcj48WWVhcj4yMDEwPC9ZZWFy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ADDIN EN.CITE.DATA (12). A recent meta-analysis which combined the results of studies with small sample sizes concluded that insomnia is associated with mild to moderate impairments on tasks assessing working memory, episodic memory, problem solving, choice reaction time, information processing and selective attention ADDIN EN.CITE <EndNote><Cite><Author>Fortier-Brochu</Author><Year>2012</Year><RecNum>172</RecNum><DisplayText>(13)</DisplayText><record><rec-number>172</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr">172</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Fortier-Brochu, E.</author><author>Beaulieu-Bonneau, S.</author><author>Ivers, H.</author><author>Morin, C. M.</author></authors></contributors><auth-address>Ecole de Psychologie, Universite Laval, Quebec, Canada. emilie.fortier-brochu.1@ulaval.ca</auth-address><titles><title>Insomnia and daytime cognitive performance: a meta-analysis</title><secondary-title>Sleep Med Rev</secondary-title><alt-title>Sleep medicine reviews</alt-title></titles><periodical><full-title>Sleep Med Rev</full-title><abbr-1>Sleep medicine reviews</abbr-1></periodical><alt-periodical><full-title>Sleep Med Rev</full-title><abbr-1>Sleep medicine reviews</abbr-1></alt-periodical><pages>83-94</pages><volume>16</volume><number>1</number><edition>2011/06/04</edition><keywords><keyword>Adult</keyword><keyword>*Cognition</keyword><keyword>Cognition Disorders/etiology</keyword><keyword>Humans</keyword><keyword>Neuropsychological Tests</keyword><keyword>Psychomotor Performance</keyword><keyword>Sleep Initiation and Maintenance Disorders/complications/*psychology</keyword></keywords><dates><year>2012</year><pub-dates><date>Feb</date></pub-dates></dates><isbn>1532-2955 (Electronic)
1087-0792 (Linking)</isbn><accession-num>21636297</accession-num><label>*</label><work-type>Meta-Analysis
Research Support, Non-U.S. Gov't</work-type><urls><related-urls><url>;(13). This review also highlighted the need for studies with greater statistical power and the assessment of a wider range of cognitive functions in order to improve our understanding of the nature and extent of cognitive impairment in insomnia. Uncertainty about the impact of insomnia on objective cognitive performance contrasts with research into the effects of experimental sleep loss, where findings have been more robust. Specifically, chronic sleep deprivation has been associated with deleterious effects across several cognitive domains, including memory and attention ADDIN EN.CITE <EndNote><Cite><Author>Lim</Author><Year>2010</Year><RecNum>506</RecNum><DisplayText>(14)</DisplayText><record><rec-number>506</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr">506</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Lim, J.</author><author>Dinges, D. F.</author></authors></contributors><auth-address>Division of Sleep and Chronobiology, Department of Psychiatry, University of Pennsylvania School of Medicine, 423 Guardian Drive, Philadelphia, PA 19104, USA. julianzl@sas.upenn.edu</auth-address><titles><title>A meta-analysis of the impact of short-term sleep deprivation on cognitive variables</title><secondary-title>Psychol Bull</secondary-title><alt-title>Psychological bulletin</alt-title></titles><periodical><full-title>Psychol Bull</full-title><abbr-1>Psychological bulletin</abbr-1></periodical><alt-periodical><full-title>Psychol Bull</full-title><abbr-1>Psychological bulletin</abbr-1></alt-periodical><pages>375-89</pages><volume>136</volume><number>3</number><keywords><keyword>Adult</keyword><keyword>Analysis of Variance</keyword><keyword>*Attention</keyword><keyword>Humans</keyword><keyword>*Memory, Short-Term</keyword><keyword>Neuropsychological Tests</keyword><keyword>*Problem Solving</keyword><keyword>*Reaction Time</keyword><keyword>Sleep Deprivation/*psychology</keyword></keywords><dates><year>2010</year><pub-dates><date>May</date></pub-dates></dates><isbn>1939-1455 (Electronic)
0033-2909 (Linking)</isbn><accession-num>20438143</accession-num><urls><related-urls><url>;(14). Evidence from prospective longitudinal studies indicates that chronic insomnia is an independent risk factor for cognitive decline PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DcmljY288L0F1dGhvcj48WWVhcj4yMDAxPC9ZZWFyPjxS
ZWNOdW0+NTA3PC9SZWNOdW0+PERpc3BsYXlUZXh0PigxNSwgMTYpPC9EaXNwbGF5VGV4dD48cmVj
b3JkPjxyZWMtbnVtYmVyPjUwNzwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJF
TiIgZGItaWQ9IjVwcndlNXNhMXN6MnNwZWVmd3I1dHgwb3hkdzlzenp4cGFzciI+NTA3PC9rZXk+
PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10
eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5DcmljY28sIE0uPC9hdXRob3I+PGF1
dGhvcj5TaW1vbnNpY2ssIEUuIE0uPC9hdXRob3I+PGF1dGhvcj5Gb2xleSwgRC4gSi48L2F1dGhv
cj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5GYWN1bHR5IG9mIE1lZGlj
aW5lLCBVbml2ZXJzaXR5IG9mIEljZWxhbmQsIFJleWtqYXZpaywgSWNlbGFuZC48L2F1dGgtYWRk
cmVzcz48dGl0bGVzPjx0aXRsZT5UaGUgaW1wYWN0IG9mIGluc29tbmlhIG9uIGNvZ25pdGl2ZSBm
dW5jdGlvbmluZyBpbiBvbGRlciBhZHVsdHM8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+SiBBbSBH
ZXJpYXRyIFNvYzwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+Sm91cm5hbCBvZiB0aGUgQW1l
cmljYW4gR2VyaWF0cmljcyBTb2NpZXR5PC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+
PGZ1bGwtdGl0bGU+SiBBbSBHZXJpYXRyIFNvYzwvZnVsbC10aXRsZT48YWJici0xPkpvdXJuYWwg
b2YgdGhlIEFtZXJpY2FuIEdlcmlhdHJpY3MgU29jaWV0eTwvYWJici0xPjwvcGVyaW9kaWNhbD48
YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+SiBBbSBHZXJpYXRyIFNvYzwvZnVsbC10aXRsZT48
YWJici0xPkpvdXJuYWwgb2YgdGhlIEFtZXJpY2FuIEdlcmlhdHJpY3MgU29jaWV0eTwvYWJici0x
PjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjExODUtOTwvcGFnZXM+PHZvbHVtZT40OTwvdm9sdW1l
PjxudW1iZXI+OTwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD5BZ2UgRmFjdG9yczwva2V5d29y
ZD48a2V5d29yZD5BZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPkNvZ25pdGlvbiBEaXNvcmRlcnMvKmVw
aWRlbWlvbG9neTwva2V5d29yZD48a2V5d29yZD5EZXByZXNzaW9uL2VwaWRlbWlvbG9neTwva2V5
d29yZD48a2V5d29yZD5GZW1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxr
ZXl3b3JkPkluY2lkZW5jZTwva2V5d29yZD48a2V5d29yZD5Mb2dpc3RpYyBNb2RlbHM8L2tleXdv
cmQ+PGtleXdvcmQ+TG9uZ2l0dWRpbmFsIFN0dWRpZXM8L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwv
a2V5d29yZD48a2V5d29yZD5NdWx0aXZhcmlhdGUgQW5hbHlzaXM8L2tleXdvcmQ+PGtleXdvcmQ+
T2RkcyBSYXRpbzwva2V5d29yZD48a2V5d29yZD5QcmV2YWxlbmNlPC9rZXl3b3JkPjxrZXl3b3Jk
PlJpc2s8L2tleXdvcmQ+PGtleXdvcmQ+U2V4IEZhY3RvcnM8L2tleXdvcmQ+PGtleXdvcmQ+U2xl
ZXAgSW5pdGlhdGlvbiBhbmQgTWFpbnRlbmFuY2UgRGlzb3JkZXJzLypjb21wbGljYXRpb25zPC9r
ZXl3b3JkPjxrZXl3b3JkPlVuaXRlZCBTdGF0ZXMvZXBpZGVtaW9sb2d5PC9rZXl3b3JkPjwva2V5
d29yZHM+PGRhdGVzPjx5ZWFyPjIwMDE8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5TZXA8L2RhdGU+
PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4wMDAyLTg2MTQgKFByaW50KSYjeEQ7MDAwMi04NjE0
IChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4xMTU1OTM3NzwvYWNjZXNzaW9uLW51bT48
dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1l
ZC8xMTU1OTM3NzwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48L3JlY29yZD48L0NpdGU+PENp
dGU+PEF1dGhvcj5KZWxpY2ljPC9BdXRob3I+PFllYXI+MjAwMjwvWWVhcj48UmVjTnVtPjUwODwv
UmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+NTA4PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+
PGtleSBhcHA9IkVOIiBkYi1pZD0iNXByd2U1c2Exc3oyc3BlZWZ3cjV0eDBveGR3OXN6enhwYXNy
Ij41MDg8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xl
Ij4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkplbGljaWMsIE0u
PC9hdXRob3I+PGF1dGhvcj5Cb3NtYSwgSC48L2F1dGhvcj48YXV0aG9yPlBvbmRzLCBSLiBXLjwv
YXV0aG9yPjxhdXRob3I+VmFuIEJveHRlbCwgTS4gUC48L2F1dGhvcj48YXV0aG9yPkhvdXgsIFAu
IEouPC9hdXRob3I+PGF1dGhvcj5Kb2xsZXMsIEouPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJp
YnV0b3JzPjxhdXRoLWFkZHJlc3M+TWFhc3RyaWNodCBCcmFpbiBhbmQgQmVoYXZpb3VyIEluc3Rp
dHV0ZSBhbmQgRXVyb3BlYW4gR3JhZHVhdGUgU2Nob29sIG9mIE5ldXJvc2NpZW5jZSAoRVVST04p
LCBEZXBhcnRtZW50IG9mIFBzeWNoaWF0cnkgYW5kIE5ldXJvcHN5Y2hvbG9neSwgVW5pdmVyc2l0
eSBvZiBNYWFzdHJpY2h0LCBNYWFzdHJpY2h0LCBUaGUgTmV0aGVybGFuZHMuIG0uamVsaWNpY0Bw
c3ljaG9sb2d5LnVuaW1hYXMubmw8L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5TdWJqZWN0
aXZlIHNsZWVwIHByb2JsZW1zIGluIGxhdGVyIGxpZmUgYXMgcHJlZGljdG9ycyBvZiBjb2duaXRp
dmUgZGVjbGluZS4gUmVwb3J0IGZyb20gdGhlIE1hYXN0cmljaHQgQWdlaW5nIFN0dWR5IChNQUFT
KTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5JbnQgSiBHZXJpYXRyIFBzeWNoaWF0cnk8L3NlY29u
ZGFyeS10aXRsZT48YWx0LXRpdGxlPkludGVybmF0aW9uYWwgam91cm5hbCBvZiBnZXJpYXRyaWMg
cHN5Y2hpYXRyeTwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPklu
dCBKIEdlcmlhdHIgUHN5Y2hpYXRyeTwvZnVsbC10aXRsZT48YWJici0xPkludGVybmF0aW9uYWwg
am91cm5hbCBvZiBnZXJpYXRyaWMgcHN5Y2hpYXRyeTwvYWJici0xPjwvcGVyaW9kaWNhbD48YWx0
LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+SW50IEogR2VyaWF0ciBQc3ljaGlhdHJ5PC9mdWxsLXRp
dGxlPjxhYmJyLTE+SW50ZXJuYXRpb25hbCBqb3VybmFsIG9mIGdlcmlhdHJpYyBwc3ljaGlhdHJ5
PC9hYmJyLTE+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+NzMtNzwvcGFnZXM+PHZvbHVtZT4xNzwv
dm9sdW1lPjxudW1iZXI+MTwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD5BZ2VkPC9rZXl3b3Jk
PjxrZXl3b3JkPkFsemhlaW1lciBEaXNlYXNlL2RpYWdub3Npcy8qZXBpZGVtaW9sb2d5L3BzeWNo
b2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+Q29ob3J0IFN0dWRpZXM8L2tleXdvcmQ+PGtleXdvcmQ+
Q29tb3JiaWRpdHk8L2tleXdvcmQ+PGtleXdvcmQ+RGVwcmVzc2l2ZSBEaXNvcmRlci9kaWFnbm9z
aXMvZXBpZGVtaW9sb2d5L3BzeWNob2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3
b3JkPjxrZXl3b3JkPkhlYWx0aCBTdXJ2ZXlzPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5
d29yZD48a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3b3JkPk1lbnRhbCBTdGF0dXMgU2NoZWR1
bGUvc3RhdGlzdGljcyAmYW1wOyBudW1lcmljYWwgZGF0YTwva2V5d29yZD48a2V5d29yZD5NaWRk
bGUgQWdlZDwva2V5d29yZD48a2V5d29yZD5Qcm9nbm9zaXM8L2tleXdvcmQ+PGtleXdvcmQ+UHJv
c3BlY3RpdmUgU3R1ZGllczwva2V5d29yZD48a2V5d29yZD5Qc3ljaG9tZXRyaWNzPC9rZXl3b3Jk
PjxrZXl3b3JkPlJlcHJvZHVjaWJpbGl0eSBvZiBSZXN1bHRzPC9rZXl3b3JkPjxrZXl3b3JkPlNs
ZWVwIFdha2UgRGlzb3JkZXJzL2RpYWdub3Npcy8qZXBpZGVtaW9sb2d5L3BzeWNob2xvZ3k8L2tl
eXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAwMjwveWVhcj48cHViLWRhdGVzPjxkYXRl
PkphbjwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjA4ODUtNjIzMCAoUHJpbnQpJiN4
RDswODg1LTYyMzAgKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjExODAyMjM0PC9hY2Nl
c3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5p
aC5nb3YvcHVibWVkLzExODAyMjM0PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjwvcmVjb3Jk
PjwvQ2l0ZT48L0VuZE5vdGU+
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DcmljY288L0F1dGhvcj48WWVhcj4yMDAxPC9ZZWFyPjxS
ZWNOdW0+NTA3PC9SZWNOdW0+PERpc3BsYXlUZXh0PigxNSwgMTYpPC9EaXNwbGF5VGV4dD48cmVj
b3JkPjxyZWMtbnVtYmVyPjUwNzwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJF
TiIgZGItaWQ9IjVwcndlNXNhMXN6MnNwZWVmd3I1dHgwb3hkdzlzenp4cGFzciI+NTA3PC9rZXk+
PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10
eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5DcmljY28sIE0uPC9hdXRob3I+PGF1
dGhvcj5TaW1vbnNpY2ssIEUuIE0uPC9hdXRob3I+PGF1dGhvcj5Gb2xleSwgRC4gSi48L2F1dGhv
cj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5GYWN1bHR5IG9mIE1lZGlj
aW5lLCBVbml2ZXJzaXR5IG9mIEljZWxhbmQsIFJleWtqYXZpaywgSWNlbGFuZC48L2F1dGgtYWRk
cmVzcz48dGl0bGVzPjx0aXRsZT5UaGUgaW1wYWN0IG9mIGluc29tbmlhIG9uIGNvZ25pdGl2ZSBm
dW5jdGlvbmluZyBpbiBvbGRlciBhZHVsdHM8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+SiBBbSBH
ZXJpYXRyIFNvYzwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+Sm91cm5hbCBvZiB0aGUgQW1l
cmljYW4gR2VyaWF0cmljcyBTb2NpZXR5PC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+
PGZ1bGwtdGl0bGU+SiBBbSBHZXJpYXRyIFNvYzwvZnVsbC10aXRsZT48YWJici0xPkpvdXJuYWwg
b2YgdGhlIEFtZXJpY2FuIEdlcmlhdHJpY3MgU29jaWV0eTwvYWJici0xPjwvcGVyaW9kaWNhbD48
YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+SiBBbSBHZXJpYXRyIFNvYzwvZnVsbC10aXRsZT48
YWJici0xPkpvdXJuYWwgb2YgdGhlIEFtZXJpY2FuIEdlcmlhdHJpY3MgU29jaWV0eTwvYWJici0x
PjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjExODUtOTwvcGFnZXM+PHZvbHVtZT40OTwvdm9sdW1l
PjxudW1iZXI+OTwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD5BZ2UgRmFjdG9yczwva2V5d29y
ZD48a2V5d29yZD5BZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPkNvZ25pdGlvbiBEaXNvcmRlcnMvKmVw
aWRlbWlvbG9neTwva2V5d29yZD48a2V5d29yZD5EZXByZXNzaW9uL2VwaWRlbWlvbG9neTwva2V5
d29yZD48a2V5d29yZD5GZW1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxr
ZXl3b3JkPkluY2lkZW5jZTwva2V5d29yZD48a2V5d29yZD5Mb2dpc3RpYyBNb2RlbHM8L2tleXdv
cmQ+PGtleXdvcmQ+TG9uZ2l0dWRpbmFsIFN0dWRpZXM8L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwv
a2V5d29yZD48a2V5d29yZD5NdWx0aXZhcmlhdGUgQW5hbHlzaXM8L2tleXdvcmQ+PGtleXdvcmQ+
T2RkcyBSYXRpbzwva2V5d29yZD48a2V5d29yZD5QcmV2YWxlbmNlPC9rZXl3b3JkPjxrZXl3b3Jk
PlJpc2s8L2tleXdvcmQ+PGtleXdvcmQ+U2V4IEZhY3RvcnM8L2tleXdvcmQ+PGtleXdvcmQ+U2xl
ZXAgSW5pdGlhdGlvbiBhbmQgTWFpbnRlbmFuY2UgRGlzb3JkZXJzLypjb21wbGljYXRpb25zPC9r
ZXl3b3JkPjxrZXl3b3JkPlVuaXRlZCBTdGF0ZXMvZXBpZGVtaW9sb2d5PC9rZXl3b3JkPjwva2V5
d29yZHM+PGRhdGVzPjx5ZWFyPjIwMDE8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5TZXA8L2RhdGU+
PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4wMDAyLTg2MTQgKFByaW50KSYjeEQ7MDAwMi04NjE0
IChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4xMTU1OTM3NzwvYWNjZXNzaW9uLW51bT48
dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1l
ZC8xMTU1OTM3NzwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48L3JlY29yZD48L0NpdGU+PENp
dGU+PEF1dGhvcj5KZWxpY2ljPC9BdXRob3I+PFllYXI+MjAwMjwvWWVhcj48UmVjTnVtPjUwODwv
UmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+NTA4PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+
PGtleSBhcHA9IkVOIiBkYi1pZD0iNXByd2U1c2Exc3oyc3BlZWZ3cjV0eDBveGR3OXN6enhwYXNy
Ij41MDg8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xl
Ij4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkplbGljaWMsIE0u
PC9hdXRob3I+PGF1dGhvcj5Cb3NtYSwgSC48L2F1dGhvcj48YXV0aG9yPlBvbmRzLCBSLiBXLjwv
YXV0aG9yPjxhdXRob3I+VmFuIEJveHRlbCwgTS4gUC48L2F1dGhvcj48YXV0aG9yPkhvdXgsIFAu
IEouPC9hdXRob3I+PGF1dGhvcj5Kb2xsZXMsIEouPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJp
YnV0b3JzPjxhdXRoLWFkZHJlc3M+TWFhc3RyaWNodCBCcmFpbiBhbmQgQmVoYXZpb3VyIEluc3Rp
dHV0ZSBhbmQgRXVyb3BlYW4gR3JhZHVhdGUgU2Nob29sIG9mIE5ldXJvc2NpZW5jZSAoRVVST04p
LCBEZXBhcnRtZW50IG9mIFBzeWNoaWF0cnkgYW5kIE5ldXJvcHN5Y2hvbG9neSwgVW5pdmVyc2l0
eSBvZiBNYWFzdHJpY2h0LCBNYWFzdHJpY2h0LCBUaGUgTmV0aGVybGFuZHMuIG0uamVsaWNpY0Bw
c3ljaG9sb2d5LnVuaW1hYXMubmw8L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5TdWJqZWN0
aXZlIHNsZWVwIHByb2JsZW1zIGluIGxhdGVyIGxpZmUgYXMgcHJlZGljdG9ycyBvZiBjb2duaXRp
dmUgZGVjbGluZS4gUmVwb3J0IGZyb20gdGhlIE1hYXN0cmljaHQgQWdlaW5nIFN0dWR5IChNQUFT
KTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5JbnQgSiBHZXJpYXRyIFBzeWNoaWF0cnk8L3NlY29u
ZGFyeS10aXRsZT48YWx0LXRpdGxlPkludGVybmF0aW9uYWwgam91cm5hbCBvZiBnZXJpYXRyaWMg
cHN5Y2hpYXRyeTwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPklu
dCBKIEdlcmlhdHIgUHN5Y2hpYXRyeTwvZnVsbC10aXRsZT48YWJici0xPkludGVybmF0aW9uYWwg
am91cm5hbCBvZiBnZXJpYXRyaWMgcHN5Y2hpYXRyeTwvYWJici0xPjwvcGVyaW9kaWNhbD48YWx0
LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+SW50IEogR2VyaWF0ciBQc3ljaGlhdHJ5PC9mdWxsLXRp
dGxlPjxhYmJyLTE+SW50ZXJuYXRpb25hbCBqb3VybmFsIG9mIGdlcmlhdHJpYyBwc3ljaGlhdHJ5
PC9hYmJyLTE+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+NzMtNzwvcGFnZXM+PHZvbHVtZT4xNzwv
dm9sdW1lPjxudW1iZXI+MTwvbnVtYmVyPjxrZXl3b3Jkcz48a2V5d29yZD5BZ2VkPC9rZXl3b3Jk
PjxrZXl3b3JkPkFsemhlaW1lciBEaXNlYXNlL2RpYWdub3Npcy8qZXBpZGVtaW9sb2d5L3BzeWNo
b2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+Q29ob3J0IFN0dWRpZXM8L2tleXdvcmQ+PGtleXdvcmQ+
Q29tb3JiaWRpdHk8L2tleXdvcmQ+PGtleXdvcmQ+RGVwcmVzc2l2ZSBEaXNvcmRlci9kaWFnbm9z
aXMvZXBpZGVtaW9sb2d5L3BzeWNob2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3
b3JkPjxrZXl3b3JkPkhlYWx0aCBTdXJ2ZXlzPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5
d29yZD48a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3b3JkPk1lbnRhbCBTdGF0dXMgU2NoZWR1
bGUvc3RhdGlzdGljcyAmYW1wOyBudW1lcmljYWwgZGF0YTwva2V5d29yZD48a2V5d29yZD5NaWRk
bGUgQWdlZDwva2V5d29yZD48a2V5d29yZD5Qcm9nbm9zaXM8L2tleXdvcmQ+PGtleXdvcmQ+UHJv
c3BlY3RpdmUgU3R1ZGllczwva2V5d29yZD48a2V5d29yZD5Qc3ljaG9tZXRyaWNzPC9rZXl3b3Jk
PjxrZXl3b3JkPlJlcHJvZHVjaWJpbGl0eSBvZiBSZXN1bHRzPC9rZXl3b3JkPjxrZXl3b3JkPlNs
ZWVwIFdha2UgRGlzb3JkZXJzL2RpYWdub3Npcy8qZXBpZGVtaW9sb2d5L3BzeWNob2xvZ3k8L2tl
eXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAwMjwveWVhcj48cHViLWRhdGVzPjxkYXRl
PkphbjwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjA4ODUtNjIzMCAoUHJpbnQpJiN4
RDswODg1LTYyMzAgKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjExODAyMjM0PC9hY2Nl
c3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5p
aC5nb3YvcHVibWVkLzExODAyMjM0PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjwvcmVjb3Jk
PjwvQ2l0ZT48L0VuZE5vdGU+
ADDIN EN.CITE.DATA (15, 16). It has also been suggested that changes in sleep architecture which tend to occur with advancing age (more sleep fragmentation, earlier awakenings and less slow wave sleep) contribute to normal, age-related cognitive decline PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BbHRlbmE8L0F1dGhvcj48WWVhcj4yMDEwPC9ZZWFyPjxS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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BbHRlbmE8L0F1dGhvcj48WWVhcj4yMDEwPC9ZZWFyPjxS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ADDIN EN.CITE.DATA (17, 18). Sleep is known to play a role in brain plasticity and memory formation and therefore chronically disturbed sleep is proposed to lead to impairment in cognition through its impact on brain function and brain health PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LcmV1dHptYW5uPC9BdXRob3I+PFllYXI+MjAxNTwvWWVh
cj48UmVjTnVtPjUxMzwvUmVjTnVtPjxEaXNwbGF5VGV4dD4oMTksIDIwKTwvRGlzcGxheVRleHQ+
PHJlY29yZD48cmVjLW51bWJlcj41MTM8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFw
cD0iRU4iIGRiLWlkPSI1cHJ3ZTVzYTFzejJzcGVlZndyNXR4MG94ZHc5c3p6eHBhc3IiPjUxMzwv
a2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9y
ZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+S3JldXR6bWFubiwgSi4gQy48
L2F1dGhvcj48YXV0aG9yPkhhdmVrZXMsIFIuPC9hdXRob3I+PGF1dGhvcj5BYmVsLCBULjwvYXV0
aG9yPjxhdXRob3I+TWVlcmxvLCBQLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48
YXV0aC1hZGRyZXNzPkNlbnRlciBmb3IgQmVoYXZpb3IgYW5kIE5ldXJvc2NpZW5jZXMsIFVuaXZl
cnNpdHkgb2YgR3JvbmluZ2VuLCBUaGUgTmV0aGVybGFuZHM7IERlcGFydG1lbnQgb2YgQmlvbG9n
eSwgVW5pdmVyc2l0eSBvZiBQZW5uc3lsdmFuaWEsIFBoaWxhZGVscGhpYSwgVW5pdGVkIFN0YXRl
cy4mI3hEO0RlcGFydG1lbnQgb2YgQmlvbG9neSwgVW5pdmVyc2l0eSBvZiBQZW5uc3lsdmFuaWEs
IFBoaWxhZGVscGhpYSwgVW5pdGVkIFN0YXRlcy4mI3hEO0NlbnRlciBmb3IgQmVoYXZpb3IgYW5k
IE5ldXJvc2NpZW5jZXMsIFVuaXZlcnNpdHkgb2YgR3JvbmluZ2VuLCBUaGUgTmV0aGVybGFuZHMu
IEVsZWN0cm9uaWMgYWRkcmVzczogUC5NZWVybG9AcnVnLm5sLjwvYXV0aC1hZGRyZXNzPjx0aXRs
ZXM+PHRpdGxlPlNsZWVwIGRlcHJpdmF0aW9uIGFuZCBoaXBwb2NhbXBhbCB2dWxuZXJhYmlsaXR5
OiBjaGFuZ2VzIGluIG5ldXJvbmFsIHBsYXN0aWNpdHksIG5ldXJvZ2VuZXNpcyBhbmQgY29nbml0
aXZlIGZ1bmN0aW9uPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPk5ldXJvc2NpZW5jZTwvc2Vjb25k
YXJ5LXRpdGxlPjxhbHQtdGl0bGU+TmV1cm9zY2llbmNlPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBl
cmlvZGljYWw+PGZ1bGwtdGl0bGU+TmV1cm9zY2llbmNlPC9mdWxsLXRpdGxlPjxhYmJyLTE+TmV1
cm9zY2llbmNlPC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRs
ZT5OZXVyb3NjaWVuY2U8L2Z1bGwtdGl0bGU+PGFiYnItMT5OZXVyb3NjaWVuY2U8L2FiYnItMT48
L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz4xNzMtOTA8L3BhZ2VzPjx2b2x1bWU+MzA5PC92b2x1bWU+
PGRhdGVzPjx5ZWFyPjIwMTU8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5Ob3YgMTk8L2RhdGU+PC9w
dWItZGF0ZXM+PC9kYXRlcz48aXNibj4xODczLTc1NDQgKEVsZWN0cm9uaWMpJiN4RDswMzA2LTQ1
MjIgKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjI1OTM3Mzk4PC9hY2Nlc3Npb24tbnVt
Pjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVi
bWVkLzI1OTM3Mzk4PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291
cmNlLW51bT4xMC4xMDE2L2oubmV1cm9zY2llbmNlLjIwMTUuMDQuMDUzPC9lbGVjdHJvbmljLXJl
c291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5BbGhvbGE8L0F1dGhvcj48
WWVhcj4yMDA3PC9ZZWFyPjxSZWNOdW0+NTE0PC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj41
MTQ8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSI1cHJ3ZTVz
YTFzejJzcGVlZndyNXR4MG94ZHc5c3p6eHBhc3IiPjUxNDwva2V5PjwvZm9yZWlnbi1rZXlzPjxy
ZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3Jz
PjxhdXRob3JzPjxhdXRob3I+QWxob2xhLCBQLjwvYXV0aG9yPjxhdXRob3I+UG9sby1LYW50b2xh
LCBQLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkRlcGFy
dG1lbnQgb2YgUHN5Y2hvbG9neSwgVW5pdmVyc2l0eSBvZiBUdXJrdSwgRkktMjAwMTQgVHVya3Us
IEZpbmxhbmQuIHBhdWxhLmFsaG9sYUB1dHUuZmk8L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRs
ZT5TbGVlcCBkZXByaXZhdGlvbjogSW1wYWN0IG9uIGNvZ25pdGl2ZSBwZXJmb3JtYW5jZTwvdGl0
bGU+PHNlY29uZGFyeS10aXRsZT5OZXVyb3BzeWNoaWF0ciBEaXMgVHJlYXQ8L3NlY29uZGFyeS10
aXRsZT48YWx0LXRpdGxlPk5ldXJvcHN5Y2hpYXRyaWMgZGlzZWFzZSBhbmQgdHJlYXRtZW50PC9h
bHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+TmV1cm9wc3ljaGlhdHIg
RGlzIFRyZWF0PC9mdWxsLXRpdGxlPjxhYmJyLTE+TmV1cm9wc3ljaGlhdHJpYyBkaXNlYXNlIGFu
ZCB0cmVhdG1lbnQ8L2FiYnItMT48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRp
dGxlPk5ldXJvcHN5Y2hpYXRyIERpcyBUcmVhdDwvZnVsbC10aXRsZT48YWJici0xPk5ldXJvcHN5
Y2hpYXRyaWMgZGlzZWFzZSBhbmQgdHJlYXRtZW50PC9hYmJyLTE+PC9hbHQtcGVyaW9kaWNhbD48
cGFnZXM+NTUzLTY3PC9wYWdlcz48dm9sdW1lPjM8L3ZvbHVtZT48bnVtYmVyPjU8L251bWJlcj48
ZGF0ZXM+PHllYXI+MjAwNzwveWVhcj48L2RhdGVzPjxpc2JuPjExNzYtNjMyOCAoUHJpbnQpJiN4
RDsxMTc2LTYzMjggKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjE5MzAwNTg1PC9hY2Nl
c3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5p
aC5nb3YvcHVibWVkLzE5MzAwNTg1PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxjdXN0b20y
PjI2NTYyOTI8L2N1c3RvbTI+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT4A
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LcmV1dHptYW5uPC9BdXRob3I+PFllYXI+MjAxNTwvWWVh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 EN.CITE.DATA (19, 20). The majority of evidence for this comes from animal models of chronic sleep deprivation, which have demonstrated reductions in hippocampal cell proliferation and generation of new neurons (for review see ADDIN EN.CITE <EndNote><Cite><Author>Kreutzmann</Author><Year>2015</Year><RecNum>513</RecNum><DisplayText>(19)</DisplayText><record><rec-number>513</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr">513</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Kreutzmann, J. C.</author><author>Havekes, R.</author><author>Abel, T.</author><author>Meerlo, P.</author></authors></contributors><auth-address>Center for Behavior and Neurosciences, University of Groningen, The Netherlands; Department of Biology, University of Pennsylvania, Philadelphia, United States.
Department of Biology, University of Pennsylvania, Philadelphia, United States.
Center for Behavior and Neurosciences, University of Groningen, The Netherlands. Electronic address: P.Meerlo@rug.nl.</auth-address><titles><title>Sleep deprivation and hippocampal vulnerability: changes in neuronal plasticity, neurogenesis and cognitive function</title><secondary-title>Neuroscience</secondary-title><alt-title>Neuroscience</alt-title></titles><periodical><full-title>Neuroscience</full-title><abbr-1>Neuroscience</abbr-1></periodical><alt-periodical><full-title>Neuroscience</full-title><abbr-1>Neuroscience</abbr-1></alt-periodical><pages>173-90</pages><volume>309</volume><dates><year>2015</year><pub-dates><date>Nov 19</date></pub-dates></dates><isbn>1873-7544 (Electronic)
0306-4522 (Linking)</isbn><accession-num>25937398</accession-num><urls><related-urls><url>;(19)). In humans, brain imaging studies have reported smaller hippocampi in those suffering from chronic insomnia PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Kb288L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxSZWNO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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Kb288L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxSZWNO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ADDIN EN.CITE.DATA (21, 22) and associations between hippocampi size and performance on a range of cognitive tests has also been demonstrated PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Kb288L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxSZWNO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 EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Kb288L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxSZWNO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 EN.CITE.DATA (21, 23), highlighting a potential pathway through which chronically disturbed sleep leads to cognitive deficits. Other studies report cortical atrophy in insomnia that might confer a risk for cognitive impairment ADDIN EN.CITE <EndNote><Cite><Author>Spiegelhalder</Author><Year>2015</Year><RecNum>658</RecNum><DisplayText>(24)</DisplayText><record><rec-number>658</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr">658</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Spiegelhalder, K.</author><author>Regen, W.</author><author>Baglioni, C.</author><author>Nissen, C.</author><author>Riemann, D.</author><author>Kyle, S. D.</author></authors></contributors><auth-address>Department of Psychophysiology/Sleep Medicine, University Medical Center Freiburg, Hauptstrasse 5, 79104, Freiburg, Germany, Kai.Spiegelhalder@uniklinik-freiburg.de.</auth-address><titles><title>Neuroimaging insights into insomnia</title><secondary-title>Curr Neurol Neurosci Rep</secondary-title><alt-title>Current neurology and neuroscience reports</alt-title></titles><periodical><full-title>Curr Neurol Neurosci Rep</full-title><abbr-1>Current neurology and neuroscience reports</abbr-1></periodical><alt-periodical><full-title>Curr Neurol Neurosci Rep</full-title><abbr-1>Current neurology and neuroscience reports</abbr-1></alt-periodical><pages>9</pages><volume>15</volume><number>3</number><keywords><keyword>Humans</keyword><keyword>Neuroimaging/*methods</keyword><keyword>Sleep Initiation and Maintenance Disorders/*pathology/*physiopathology</keyword></keywords><dates><year>2015</year><pub-dates><date>Mar</date></pub-dates></dates><isbn>1534-6293 (Electronic)
1528-4042 (Linking)</isbn><accession-num>25687698</accession-num><urls><related-urls><url>;(24).CBT-I is a psychological treatment which aims to change the patterns of maladaptive thinking and behaviour which are proposed to maintain sleep difficulties ADDIN EN.CITE <EndNote><Cite><Author>Morin</Author><Year>2003</Year><RecNum>472</RecNum><DisplayText>(25, 26)</DisplayText><record><rec-number>472</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr">472</key></foreign-keys><ref-type name="Book">6</ref-type><contributors><authors><author>Morin, Charles M.</author><author>Espie, Colin A.</author></authors></contributors><titles><title>Insomnia : a clinical guide to assessment and treatment</title></titles><keywords><keyword>Insomnia.</keyword></keywords><dates><year>2003</year></dates><pub-location>New York ; London</pub-location><publisher>Kluwer Academic/Plenum</publisher><isbn>0306477505 : ?32.00</isbn><accession-num>bA417852</accession-num><call-num>616.84982 22
British Library HMNTS YK.2004.a.3917</call-num><urls></urls></record></Cite><Cite><Author>Edinger</Author><Year>2008</Year><RecNum>477</RecNum><record><rec-number>477</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr">477</key></foreign-keys><ref-type name="Book">6</ref-type><contributors><authors><author>Edinger, Jack D.</author><author>Carney, Colleen</author></authors></contributors><titles><title>Overcoming insomnia : a cognitive-behavioral therapy approach : therapist guide</title></titles><keywords><keyword>Insomnia Treatment Popular works.</keyword><keyword>Cognitive therapy.</keyword><keyword>Sleep Initiation and Maintenance Disorders therapy.</keyword><keyword>Cognitive Therapy methods.</keyword></keywords><dates><year>2008</year></dates><pub-location>Oxford ; New York</pub-location><publisher>Oxford University Press</publisher><isbn>9780195365894 (pbk. : alk. paper)
0195365895 (pbk. : alk. paper)</isbn><accession-num>(OCoLC)ocn182613540</accession-num><call-num>616.8498206 22
British Library HMNTS YK.2016.b.83</call-num><urls><related-urls><url>Table of contents only ;(25, 26). Multiple reviews and meta-analyses support the efficacy of CBT-I in creating long lasting improvements in various indices of sleep, including sleep efficiency, sleep onset latency and wake-time after sleep onset (WASO) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5UcmF1ZXI8L0F1dGhvcj48WWVhcj4yMDE1PC9ZZWFyPjxS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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5UcmF1ZXI8L0F1dGhvcj48WWVhcj4yMDE1PC9ZZWFyPjxS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ADDIN EN.CITE.DATA (27, 28). When asked to describe the experience of insomnia it is usually the problems encountered during wake and the pervasive impact that sleep difficulties have on quality of life and wellbeing that are emphasised, as opposed to specific difficulties with the sleep initiation/maintenance of sleep PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DYXJleTwvQXV0aG9yPjxZZWFyPjIwMDU8L1llYXI+PFJl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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DYXJleTwvQXV0aG9yPjxZZWFyPjIwMDU8L1llYXI+PFJl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ADDIN EN.CITE.DATA (10, 11). Indeed, there is evidence that the perceived impact of sleep disturbance on daytime functioning is what prompts individuals with insomnia to pursue treatment PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Nb3JpbjwvQXV0aG9yPjxZZWFyPjIwMDY8L1llYXI+PFJl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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Nb3JpbjwvQXV0aG9yPjxZZWFyPjIwMDY8L1llYXI+PFJl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ADDIN EN.CITE.DATA (29, 30). It seems that medical advice is sought once a certain level of daytime dysfunction is reached, in the hope that treatment will remedy perceived impairments ADDIN EN.CITE <EndNote><Cite><Author>Henry</Author><Year>2008</Year><RecNum>165</RecNum><DisplayText>(31)</DisplayText><record><rec-number>165</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr">165</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Henry, D.</author><author>McClellen, D.</author><author>Rosenthal, L.</author><author>Dedrick, D.</author><author>Gosdin, M.</author></authors></contributors><auth-address>University of North Texas, Denton, TX 76203, USA. dhenry@pacs.unt.edu</auth-address><titles><title>Is sleep really for sissies? Understanding the role of work in insomnia in the US</title><secondary-title>Soc Sci Med</secondary-title></titles><pages>715-26</pages><volume>66</volume><number>3</number><edition>2007/11/17</edition><keywords><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Qualitative Research</keyword><keyword>*Sleep</keyword><keyword>Sleep Initiation and Maintenance Disorders/*etiology</keyword><keyword>United States</keyword><keyword>*Work</keyword></keywords><dates><year>2008</year><pub-dates><date>Feb</date></pub-dates></dates><isbn>0277-9536 (Print)
0277-9536 (Linking)</isbn><accession-num>18006129</accession-num><urls><related-urls><url>;(31). Accordingly, treatment options for insomnia should aim to improve not only the sleep deficits, but also the daytime symptoms that contribute to the burden of the disorder ADDIN EN.CITE <EndNote><Cite><Author>Wade</Author><Year>2010</Year><RecNum>1</RecNum><DisplayText>(32)</DisplayText><record><rec-number>1</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr">1</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Wade, A. G.</author></authors></contributors><auth-address>CPS Research, Todd Campus, 3 Acre Rd, Glasgow, G20 0XA, Scotland. alangwade@fastmail.fm</auth-address><titles><title>The societal costs of insomnia</title><secondary-title>Neuropsychiatr Dis Treat</secondary-title><alt-title>Neuropsychiatric disease and treatment</alt-title></titles><periodical><full-title>Neuropsychiatr Dis Treat</full-title><abbr-1>Neuropsychiatric disease and treatment</abbr-1></periodical><alt-periodical><full-title>Neuropsychiatr Dis Treat</full-title><abbr-1>Neuropsychiatric disease and treatment</abbr-1></alt-periodical><pages>1-18</pages><volume>7</volume><edition>2011/02/18</edition><dates><year>2010</year></dates><isbn>1178-2021 (Electronic)
1176-6328 (Linking)</isbn><accession-num>21326650</accession-num><urls><related-urls><url>;(32). However, relatively little is known about the effects of CBT-I on daytime symptoms. Recent reviews have concluded that psychological treatment for insomnia is associated with improvements in quality of life PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LeWxlPC9BdXRob3I+PFllYXI+MjAxMDwvWWVhcj48UmVj
TnVtPjE0MDwvUmVjTnVtPjxEaXNwbGF5VGV4dD4oMTEsIDMzKTwvRGlzcGxheVRleHQ+PHJlY29y
ZD48cmVjLW51bWJlcj4xNDA8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4i
IGRiLWlkPSI1cHJ3ZTVzYTFzejJzcGVlZndyNXR4MG94ZHc5c3p6eHBhc3IiPjE0MDwva2V5Pjwv
Zm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlw
ZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+S3lsZSwgUy4gRC48L2F1dGhvcj48YXV0
aG9yPkVzcGllLCBDLiBBLjwvYXV0aG9yPjxhdXRob3I+TW9yZ2FuLCBLLjwvYXV0aG9yPjwvYXV0
aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkZhY3VsdHkgb2YgTWVkaWNpbmUsIFVu
aXZlcnNpdHkgb2YgR2xhc2dvdyBTbGVlcCBDZW50cmUsIFNhY2tsZXIgSW5zdGl0dXRlIG9mIFBz
eWNob2Jpb2xvZ2ljYWwgUmVzZWFyY2gsIFVuaXZlcnNpdHkgb2YgR2xhc2dvdywgU2NvdGxhbmQs
IFVLLiBzLmQua3lsZUBjbGlubWVkLmdsYS5hYy51azwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRp
dGxlPiZxdW90Oy4uLk5vdCBqdXN0IGEgbWlub3IgdGhpbmcsIGl0IGlzIHNvbWV0aGluZyBtYWpv
ciwgd2hpY2ggc3RvcHMgeW91IGZyb20gZnVuY3Rpb25pbmcgZGFpbHkmcXVvdDs6IHF1YWxpdHkg
b2YgbGlmZSBhbmQgZGF5dGltZSBmdW5jdGlvbmluZyBpbiBpbnNvbW5pYTwvdGl0bGU+PHNlY29u
ZGFyeS10aXRsZT5CZWhhdiBTbGVlcCBNZWQ8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkJl
aGF2aW9yYWwgc2xlZXAgbWVkaWNpbmU8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48
ZnVsbC10aXRsZT5CZWhhdiBTbGVlcCBNZWQ8L2Z1bGwtdGl0bGU+PGFiYnItMT5CZWhhdmlvcmFs
IHNsZWVwIG1lZGljaW5lPC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVs
bC10aXRsZT5CZWhhdiBTbGVlcCBNZWQ8L2Z1bGwtdGl0bGU+PGFiYnItMT5CZWhhdmlvcmFsIHNs
ZWVwIG1lZGljaW5lPC9hYmJyLTE+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+MTIzLTQwPC9wYWdl
cz48dm9sdW1lPjg8L3ZvbHVtZT48bnVtYmVyPjM8L251bWJlcj48ZWRpdGlvbj4yMDEwLzA2LzI5
PC9lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5BZHVsdDwva2V5d29yZD48a2V5d29yZD5CZWhh
dmlvcmFsIFN5bXB0b21zLypjb21wbGljYXRpb25zPC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFsZTwv
a2V5d29yZD48a2V5d29yZD5Gb2N1cyBHcm91cHM8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9r
ZXl3b3JkPjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+TWVkaWNhbCBSZWNvcmRzPC9r
ZXl3b3JkPjxrZXl3b3JkPk1pZGRsZSBBZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPlF1YWxpdGF0aXZl
IFJlc2VhcmNoPC9rZXl3b3JkPjxrZXl3b3JkPlF1YWxpdHkgb2YgTGlmZS8qcHN5Y2hvbG9neTwv
a2V5d29yZD48a2V5d29yZD5TbGVlcCBJbml0aWF0aW9uIGFuZCBNYWludGVuYW5jZSBEaXNvcmRl
cnMvY29tcGxpY2F0aW9ucy8qcHN5Y2hvbG9neTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48
eWVhcj4yMDEwPC95ZWFyPjwvZGF0ZXM+PGlzYm4+MTU0MC0yMDEwIChFbGVjdHJvbmljKSYjeEQ7
MTU0MC0yMDAyIChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4yMDU4Mjc1NjwvYWNjZXNz
aW9uLW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWgu
Z292L3B1Ym1lZC8yMDU4Mjc1NjwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25p
Yy1yZXNvdXJjZS1udW0+MTAuMTA4MC8xNTQwMjAwMi4yMDEwLjQ4NzQ1MDwvZWxlY3Ryb25pYy1y
ZXNvdXJjZS1udW0+PGxhbmd1YWdlPmVuZzwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9DaXRlPjxDaXRl
PjxBdXRob3I+S3lsZTwvQXV0aG9yPjxZZWFyPjIwMTA8L1llYXI+PFJlY051bT4yMDU8L1JlY051
bT48cmVjb3JkPjxyZWMtbnVtYmVyPjIwNTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkg
YXBwPSJFTiIgZGItaWQ9IjVwcndlNXNhMXN6MnNwZWVmd3I1dHgwb3hkdzlzenp4cGFzciI+MjA1
PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8
L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5LeWxlLCBTLiBELjwvYXV0
aG9yPjxhdXRob3I+TW9yZ2FuLCBLLjwvYXV0aG9yPjxhdXRob3I+RXNwaWUsIEMuIEEuPC9hdXRo
b3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+VW5pdmVyc2l0eSBvZiBH
bGFzZ293IFNsZWVwIENlbnRyZSwgU2Fja2xlciBJbnN0aXR1dGUgb2YgUHN5Y2hvYmlvbG9naWNh
bCBSZXNlYXJjaCwgRmFjdWx0eSBvZiBNZWRpY2luZSwgU291dGhlcm4gR2VuZXJhbCBIb3NwaXRh
bCwgR2xhc2dvdyBHNTEgNFRGLCBTY290bGFuZC4gcy5kLmt5bGVAY2xpbm1lZC5nbGEuYWMudWs8
L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5JbnNvbW5pYSBhbmQgaGVhbHRoLXJlbGF0ZWQg
cXVhbGl0eSBvZiBsaWZlPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPlNsZWVwIE1lZCBSZXY8L3Nl
Y29uZGFyeS10aXRsZT48YWx0LXRpdGxlPlNsZWVwIG1lZGljaW5lIHJldmlld3M8L2FsdC10aXRs
ZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5TbGVlcCBNZWQgUmV2PC9mdWxsLXRp
dGxlPjxhYmJyLTE+U2xlZXAgbWVkaWNpbmUgcmV2aWV3czwvYWJici0xPjwvcGVyaW9kaWNhbD48
YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+U2xlZXAgTWVkIFJldjwvZnVsbC10aXRsZT48YWJi
ci0xPlNsZWVwIG1lZGljaW5lIHJldmlld3M8L2FiYnItMT48L2FsdC1wZXJpb2RpY2FsPjxwYWdl
cz42OS04MjwvcGFnZXM+PHZvbHVtZT4xNDwvdm9sdW1lPjxudW1iZXI+MTwvbnVtYmVyPjxlZGl0
aW9uPjIwMDkvMTIvMDg8L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkNvc3Qgb2YgSWxsbmVz
czwva2V5d29yZD48a2V5d29yZD4qSGVhbHRoIFN0YXR1czwva2V5d29yZD48a2V5d29yZD5IdW1h
bnM8L2tleXdvcmQ+PGtleXdvcmQ+UXVhbGl0eSBvZiBMaWZlLypwc3ljaG9sb2d5PC9rZXl3b3Jk
PjxrZXl3b3JkPlNsZWVwIEluaXRpYXRpb24gYW5kIE1haW50ZW5hbmNlIERpc29yZGVycy8qcHN5
Y2hvbG9neTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDEwPC95ZWFyPjxwdWIt
ZGF0ZXM+PGRhdGU+RmViPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTUzMi0yOTU1
IChFbGVjdHJvbmljKSYjeEQ7MTA4Ny0wNzkyIChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51
bT4xOTk2MjkyMjwvYWNjZXNzaW9uLW51bT48d29yay10eXBlPlJldmlldzwvd29yay10eXBlPjx1
cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVk
LzE5OTYyOTIyPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNl
LW51bT4xMC4xMDE2L2ouc21ydi4yMDA5LjA3LjAwNDwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+
PGxhbmd1YWdlPmVuZzwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT5=
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LeWxlPC9BdXRob3I+PFllYXI+MjAxMDwvWWVhcj48UmVj
TnVtPjE0MDwvUmVjTnVtPjxEaXNwbGF5VGV4dD4oMTEsIDMzKTwvRGlzcGxheVRleHQ+PHJlY29y
ZD48cmVjLW51bWJlcj4xNDA8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4i
IGRiLWlkPSI1cHJ3ZTVzYTFzejJzcGVlZndyNXR4MG94ZHc5c3p6eHBhc3IiPjE0MDwva2V5Pjwv
Zm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlw
ZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+S3lsZSwgUy4gRC48L2F1dGhvcj48YXV0
aG9yPkVzcGllLCBDLiBBLjwvYXV0aG9yPjxhdXRob3I+TW9yZ2FuLCBLLjwvYXV0aG9yPjwvYXV0
aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkZhY3VsdHkgb2YgTWVkaWNpbmUsIFVu
aXZlcnNpdHkgb2YgR2xhc2dvdyBTbGVlcCBDZW50cmUsIFNhY2tsZXIgSW5zdGl0dXRlIG9mIFBz
eWNob2Jpb2xvZ2ljYWwgUmVzZWFyY2gsIFVuaXZlcnNpdHkgb2YgR2xhc2dvdywgU2NvdGxhbmQs
IFVLLiBzLmQua3lsZUBjbGlubWVkLmdsYS5hYy51azwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRp
dGxlPiZxdW90Oy4uLk5vdCBqdXN0IGEgbWlub3IgdGhpbmcsIGl0IGlzIHNvbWV0aGluZyBtYWpv
ciwgd2hpY2ggc3RvcHMgeW91IGZyb20gZnVuY3Rpb25pbmcgZGFpbHkmcXVvdDs6IHF1YWxpdHkg
b2YgbGlmZSBhbmQgZGF5dGltZSBmdW5jdGlvbmluZyBpbiBpbnNvbW5pYTwvdGl0bGU+PHNlY29u
ZGFyeS10aXRsZT5CZWhhdiBTbGVlcCBNZWQ8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkJl
aGF2aW9yYWwgc2xlZXAgbWVkaWNpbmU8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48
ZnVsbC10aXRsZT5CZWhhdiBTbGVlcCBNZWQ8L2Z1bGwtdGl0bGU+PGFiYnItMT5CZWhhdmlvcmFs
IHNsZWVwIG1lZGljaW5lPC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVs
bC10aXRsZT5CZWhhdiBTbGVlcCBNZWQ8L2Z1bGwtdGl0bGU+PGFiYnItMT5CZWhhdmlvcmFsIHNs
ZWVwIG1lZGljaW5lPC9hYmJyLTE+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+MTIzLTQwPC9wYWdl
cz48dm9sdW1lPjg8L3ZvbHVtZT48bnVtYmVyPjM8L251bWJlcj48ZWRpdGlvbj4yMDEwLzA2LzI5
PC9lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5BZHVsdDwva2V5d29yZD48a2V5d29yZD5CZWhh
dmlvcmFsIFN5bXB0b21zLypjb21wbGljYXRpb25zPC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFsZTwv
a2V5d29yZD48a2V5d29yZD5Gb2N1cyBHcm91cHM8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9r
ZXl3b3JkPjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+TWVkaWNhbCBSZWNvcmRzPC9r
ZXl3b3JkPjxrZXl3b3JkPk1pZGRsZSBBZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPlF1YWxpdGF0aXZl
IFJlc2VhcmNoPC9rZXl3b3JkPjxrZXl3b3JkPlF1YWxpdHkgb2YgTGlmZS8qcHN5Y2hvbG9neTwv
a2V5d29yZD48a2V5d29yZD5TbGVlcCBJbml0aWF0aW9uIGFuZCBNYWludGVuYW5jZSBEaXNvcmRl
cnMvY29tcGxpY2F0aW9ucy8qcHN5Y2hvbG9neTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48
eWVhcj4yMDEwPC95ZWFyPjwvZGF0ZXM+PGlzYm4+MTU0MC0yMDEwIChFbGVjdHJvbmljKSYjeEQ7
MTU0MC0yMDAyIChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4yMDU4Mjc1NjwvYWNjZXNz
aW9uLW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWgu
Z292L3B1Ym1lZC8yMDU4Mjc1NjwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25p
Yy1yZXNvdXJjZS1udW0+MTAuMTA4MC8xNTQwMjAwMi4yMDEwLjQ4NzQ1MDwvZWxlY3Ryb25pYy1y
ZXNvdXJjZS1udW0+PGxhbmd1YWdlPmVuZzwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9DaXRlPjxDaXRl
PjxBdXRob3I+S3lsZTwvQXV0aG9yPjxZZWFyPjIwMTA8L1llYXI+PFJlY051bT4yMDU8L1JlY051
bT48cmVjb3JkPjxyZWMtbnVtYmVyPjIwNTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkg
YXBwPSJFTiIgZGItaWQ9IjVwcndlNXNhMXN6MnNwZWVmd3I1dHgwb3hkdzlzenp4cGFzciI+MjA1
PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8
L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5LeWxlLCBTLiBELjwvYXV0
aG9yPjxhdXRob3I+TW9yZ2FuLCBLLjwvYXV0aG9yPjxhdXRob3I+RXNwaWUsIEMuIEEuPC9hdXRo
b3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+VW5pdmVyc2l0eSBvZiBH
bGFzZ293IFNsZWVwIENlbnRyZSwgU2Fja2xlciBJbnN0aXR1dGUgb2YgUHN5Y2hvYmlvbG9naWNh
bCBSZXNlYXJjaCwgRmFjdWx0eSBvZiBNZWRpY2luZSwgU291dGhlcm4gR2VuZXJhbCBIb3NwaXRh
bCwgR2xhc2dvdyBHNTEgNFRGLCBTY290bGFuZC4gcy5kLmt5bGVAY2xpbm1lZC5nbGEuYWMudWs8
L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5JbnNvbW5pYSBhbmQgaGVhbHRoLXJlbGF0ZWQg
cXVhbGl0eSBvZiBsaWZlPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPlNsZWVwIE1lZCBSZXY8L3Nl
Y29uZGFyeS10aXRsZT48YWx0LXRpdGxlPlNsZWVwIG1lZGljaW5lIHJldmlld3M8L2FsdC10aXRs
ZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5TbGVlcCBNZWQgUmV2PC9mdWxsLXRp
dGxlPjxhYmJyLTE+U2xlZXAgbWVkaWNpbmUgcmV2aWV3czwvYWJici0xPjwvcGVyaW9kaWNhbD48
YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+U2xlZXAgTWVkIFJldjwvZnVsbC10aXRsZT48YWJi
ci0xPlNsZWVwIG1lZGljaW5lIHJldmlld3M8L2FiYnItMT48L2FsdC1wZXJpb2RpY2FsPjxwYWdl
cz42OS04MjwvcGFnZXM+PHZvbHVtZT4xNDwvdm9sdW1lPjxudW1iZXI+MTwvbnVtYmVyPjxlZGl0
aW9uPjIwMDkvMTIvMDg8L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkNvc3Qgb2YgSWxsbmVz
czwva2V5d29yZD48a2V5d29yZD4qSGVhbHRoIFN0YXR1czwva2V5d29yZD48a2V5d29yZD5IdW1h
bnM8L2tleXdvcmQ+PGtleXdvcmQ+UXVhbGl0eSBvZiBMaWZlLypwc3ljaG9sb2d5PC9rZXl3b3Jk
PjxrZXl3b3JkPlNsZWVwIEluaXRpYXRpb24gYW5kIE1haW50ZW5hbmNlIERpc29yZGVycy8qcHN5
Y2hvbG9neTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDEwPC95ZWFyPjxwdWIt
ZGF0ZXM+PGRhdGU+RmViPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTUzMi0yOTU1
IChFbGVjdHJvbmljKSYjeEQ7MTA4Ny0wNzkyIChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51
bT4xOTk2MjkyMjwvYWNjZXNzaW9uLW51bT48d29yay10eXBlPlJldmlldzwvd29yay10eXBlPjx1
cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVk
LzE5OTYyOTIyPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNl
LW51bT4xMC4xMDE2L2ouc21ydi4yMDA5LjA3LjAwNDwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+
PGxhbmd1YWdlPmVuZzwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT5=
ADDIN EN.CITE.DATA (11, 33). However, quality of life is a broad concept, encompassing aspects of physical and psychological wellbeing. Moreover, quality of life is usually assessed using instruments which were not developed specifically for use in insomnia populations. Therefore, the impact of treatment on those aspects of daytime functioning which are known to be of particular concern in insomnia is not clear. The aim of the current review was to conduct a systematic appraisal of the literature and evaluate the evidence for the effects of CBT-I on cognitive functioning. We chose to focus on cognition because impairments in this area are one of the most commonly endorsed daytime complaints PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Fc3BpZTwvQXV0aG9yPjxZZWFyPjIwMTI8L1llYXI+PFJl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==
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Fc3BpZTwvQXV0aG9yPjxZZWFyPjIwMTI8L1llYXI+PFJl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==
ADDIN EN.CITE.DATA (34, 35) and there is evidence from both subjective reports and objective measures that individuals with insomnia are characterised by cognitive deficits compared to good sleepers. To our knowledge, the impact of CBT-I on cognition has yet to be evaluated systematically. This is surprising because impaired cognition may underlie many of the adverse consequences of insomnia, such as lowered work productivity, increased frequency of accidents PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MZWdlcjwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+PFJl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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MZWdlcjwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+PFJl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ADDIN EN.CITE.DATA (36) and declining health PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TbWl0czwvQXV0aG9yPjxZZWFyPjE5OTk8L1llYXI+PFJl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 EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TbWl0czwvQXV0aG9yPjxZZWFyPjE5OTk8L1llYXI+PFJl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 EN.CITE.DATA (37). METHODAs part of the review, quantitative data regarding effect sizes are presented. The standardised mean difference (SMD) was used as a measure of effect size and was calculated for studies utilising an RCT design, providing the necessary post-treatment and follow-up data. A meta-analysis was not considered appropriate for the current review due to the small number of studies available and the considerable heterogeneity in the methodology and outcomes of included studies.Search strategy and selectionOnline databases EMBASE, PsycINFO, MEDLINE, MEDLINE In-Process, All EBM Reviews, CINAHL and the Cochrane Library were searched from inception to 19th March 2016. The review used a title and abstract word strategy, which included the following terms: (sleeplessness OR insomnia* OR “sleep initiation” OR “sleep maintenance” OR “sleep disorder*” OR dysomnia* OR “poor sleep*” OR “sleep problem*” OR “sleep disturbance*”) AND (“cognitive behav* therap*” OR “behav* therap*” OR CBT OR CBT-I OR ICBT OR “self-help” OR “sleep hygiene” OR “stimulus control” OR “sleep restriction” OR relaxation OR “behav* modification” OR “cognitive therap*” OR imagery OR psychotherap*). Reference lists of published meta-analyses and systematic reviews of CBT-I trials were also searched to locate additional papers PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5UcmF1ZXI8L0F1dGhvcj48WWVhcj4yMDE1PC9ZZWFyPjxS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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5UcmF1ZXI8L0F1dGhvcj48WWVhcj4yMDE1PC9ZZWFyPjxS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ADDIN EN.CITE.DATA (27, 38).Citations were exported to reference management software and duplicates were removed. Titles and abstracts were reviewed. If the abstract indicated that the study evaluated a psychological treatment for insomnia, the full text was acquired to identify if cognitive functioning was measured as a treatment outcome. Relevant articles were then assessed against the inclusion and exclusion criteria. For each of the articles identified, the reference list was searched and the article was entered into the “similar articles” search tool in PUBMED, in order to find additional relevant articles. Reviews, opinions, editorials, grey literature and conference abstracts were not included. Criteria for inclusion of research articlesEmpirical studies were included if they recruited an adult sample (18 years and over) with insomnia at either the disorder or symptom level, as defined by the diagnostic and statistical manual for mental disorders (e.g. DSM-V) ADDIN EN.CITE <EndNote><Cite><RecNum>3</RecNum><DisplayText>(7)</DisplayText><record><rec-number>3</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr">3</key></foreign-keys><ref-type name="Book">6</ref-type><contributors><authors><author>American Psychiatric Association</author></authors></contributors><titles><title>Diagnostic and statistical manual of mental disorders : DSM-5</title><alt-title>Dsm-5</alt-title></titles><edition>Fifth edition.</edition><keywords><keyword>Mental illness Diagnosis Handbooks, manuals, etc.</keyword><keyword>Mental illness Statistics.</keyword><keyword>Mental Disorders classification.</keyword><keyword>Mental Disorders diagnosis.</keyword><keyword>Diagnostic and statistical manual of mental disorders. 5th ed.</keyword></keywords><dates><year>2013</year></dates><pub-location>Arlington, VA</pub-location><publisher>American Psychiatric Publishing</publisher><isbn>9780890425541 (Hardcover)
9780890425558 (Paperback)</isbn><accession-num>(DNLM)101604226</accession-num><call-num>616.89075 23
British Library DSC m13/.15124
British Library STI (B) 616.89075
British Library STI (B) 616.89075 Enquiry Desk Science 2</call-num><urls></urls></record></Cite></EndNote>(7) , the international classification of sleep disorders ADDIN EN.CITE <EndNote><Cite><Year>2005</Year><RecNum>37</RecNum><DisplayText>(1)</DisplayText><record><rec-number>37</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr">37</key></foreign-keys><ref-type name="Book">6</ref-type><contributors></contributors><titles><title>The international classification of sleep disorders : diagnostic & coding manual</title></titles><edition>2nd ed.</edition><dates><year>2005</year></dates><pub-location>Westchester, Ill.</pub-location><publisher>American Academy of Sleep Medicine</publisher><isbn>0965722023 (pbk.)</isbn><call-num>British Library DSC m06/.34596</call-num><urls></urls></record></Cite></EndNote>(1), research criteria for insomnia ADDIN EN.CITE <EndNote><Cite><Author>Edinger</Author><Year>2004</Year><RecNum>134</RecNum><DisplayText>(2)</DisplayText><record><rec-number>134</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr">134</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Edinger, J. D.</author><author>Bonnet, M. H.</author><author>Bootzin, R. R.</author><author>Doghramji, K.</author><author>Dorsey, C. M.</author><author>Espie, C. A.</author><author>Jamieson, A. O.</author><author>McCall, W. V.</author><author>Morin, C. M.</author><author>Stepanski, E. J.</author></authors></contributors><auth-address>VA Medical Center, Durham, NC, USA.</auth-address><titles><title>Derivation of research diagnostic criteria for insomnia: report of an American Academy of Sleep Medicine Work Group</title><secondary-title>Sleep</secondary-title><alt-title>Sleep</alt-title></titles><periodical><full-title>Sleep</full-title><abbr-1>Sleep</abbr-1></periodical><alt-periodical><full-title>Sleep</full-title><abbr-1>Sleep</abbr-1></alt-periodical><pages>1567-96</pages><volume>27</volume><number>8</number><edition>2005/02/03</edition><keywords><keyword>Diagnostic and Statistical Manual of Mental Disorders</keyword><keyword>Humans</keyword><keyword>Reference Values</keyword><keyword>Reproducibility of Results</keyword><keyword>Sleep Initiation and Maintenance Disorders/classification/*diagnosis</keyword></keywords><dates><year>2004</year><pub-dates><date>Dec 15</date></pub-dates></dates><isbn>0161-8105 (Print)
0161-8105 (Linking)</isbn><accession-num>15683149</accession-num><work-type>Consensus Development Conference
Research Support, Non-U.S. Gov't
Review</work-type><urls><related-urls><url>;(2) or measures of insomnia severity, such as the insomnia severity index (ISI) ADDIN EN.CITE <EndNote><Cite><Author>Bastien</Author><Year>2001</Year><RecNum>213</RecNum><DisplayText>(39)</DisplayText><record><rec-number>213</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr">213</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Bastien, C. H.</author><author>Vallieres, A.</author><author>Morin, C. M.</author></authors></contributors><auth-address>Ecole de Psychologie and Centre d'Etude des Troubles du Sommeil, Universite Laval, Ste-Foy, G1K 7P4, Quebec, Canada</auth-address><titles><title>Validation of the Insomnia Severity Index as an outcome measure for insomnia research</title><secondary-title>Sleep Med</secondary-title><alt-title>Sleep medicine</alt-title></titles><periodical><full-title>Sleep Med</full-title><abbr-1>Sleep medicine</abbr-1></periodical><alt-periodical><full-title>Sleep Med</full-title><abbr-1>Sleep medicine</abbr-1></alt-periodical><pages>297-307</pages><volume>2</volume><number>4</number><edition>2001/07/05</edition><dates><year>2001</year><pub-dates><date>Jul</date></pub-dates></dates><isbn>1878-5506 (Electronic)
1389-9457 (Linking)</isbn><accession-num>11438246</accession-num><urls><related-urls><url>;(39) and the Pittsburgh sleep quality index (PSQI) ADDIN EN.CITE <EndNote><Cite><Author>Buysse</Author><Year>1989</Year><RecNum>220</RecNum><DisplayText>(40)</DisplayText><record><rec-number>220</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr">220</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Buysse, D. J.</author><author>Reynolds, C. F., 3rd</author><author>Monk, T. H.</author><author>Berman, S. R.</author><author>Kupfer, D. J.</author></authors></contributors><auth-address>Department of Psychiatry, University of Pittsburgh School of Medicine, PA.</auth-address><titles><title>The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research</title><secondary-title>Psychiatry Res</secondary-title><alt-title>Psychiatry research</alt-title></titles><periodical><full-title>Psychiatry Res</full-title><abbr-1>Psychiatry research</abbr-1></periodical><alt-periodical><full-title>Psychiatry Res</full-title><abbr-1>Psychiatry research</abbr-1></alt-periodical><pages>193-213</pages><volume>28</volume><number>2</number><edition>1989/05/01</edition><keywords><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Aged, 80 and over</keyword><keyword>Depression/*psychology</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>*Psychological Tests</keyword><keyword>Psychometrics</keyword><keyword>Sleep Initiation and Maintenance Disorders/*diagnosis/psychology</keyword><keyword>*Sleep Stages</keyword></keywords><dates><year>1989</year><pub-dates><date>May</date></pub-dates></dates><isbn>0165-1781 (Print)
0165-1781 (Linking)</isbn><accession-num>2748771</accession-num><work-type>Research Support, U.S. Gov't, P.H.S.</work-type><urls><related-urls><url>;(40). Studies using samples where insomnia was comorbid with, or secondary to, a health or psychiatric condition were eligible for inclusion. The treatment for insomnia was required to incorporate at least two of the five most widely accepted components of CBT-I ADDIN EN.CITE <EndNote><Cite><Author>Morin</Author><Year>2012</Year><RecNum>221</RecNum><DisplayText>(41)</DisplayText><record><rec-number>221</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr">221</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Morin, C. M.</author><author>Benca, R.</author></authors></contributors><auth-address>Universite Laval, Quebec City, QC, Canada. cmorin@psy.ulaval.ca</auth-address><titles><title>Chronic insomnia</title><secondary-title>Lancet</secondary-title></titles><periodical><full-title>Lancet</full-title><abbr-1>Lancet</abbr-1></periodical><pages>1129-41</pages><volume>379</volume><number>9821</number><edition>2012/01/24</edition><keywords><keyword>Arousal/physiology</keyword><keyword>Brain/physiopathology</keyword><keyword>Chronic Disease</keyword><keyword>*Cognitive Therapy</keyword><keyword>Comorbidity</keyword><keyword>Drug Therapy, Combination</keyword><keyword>GABA-A Receptor Agonists/*therapeutic use</keyword><keyword>Humans</keyword><keyword>Prognosis</keyword><keyword>Sleep Initiation and Maintenance Disorders/epidemiology/physiopathology/*therapy</keyword><keyword>Treatment Outcome</keyword></keywords><dates><year>2012</year><pub-dates><date>Mar 24</date></pub-dates></dates><isbn>1474-547X (Electronic)
0140-6736 (Linking)</isbn><accession-num>22265700</accession-num><work-type>Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review</work-type><urls><related-urls><url>(11)60750-2</electronic-resource-num><language>eng</language></record></Cite></EndNote>(41); a cognitive therapeutic component (e.g., cognitive restructuring), stimulus control, sleep restriction, sleep hygiene and relaxation. There was no requirement for the treatment to combine cognitive and behavioural components and we did not specify inclusion criteria on the basis of delivery modality or duration of treatment. Treatments which were modified for a particular population and/or comorbid condition were eligible. Studies in which the treatment comprised therapies from other treatment modalities (e.g. bright light therapy or hypnotic medication) were not included. In order to be eligible the study was required to assess cognitive functioning as a treatment outcome. Studies were classified as having assessed cognitive functioning if they administered a measure which probed one of the following domains: attention, concentration, perception, memory, verbal functions, construction, concept formation, reasoning, executive functions or motor performance ADDIN EN.CITE <EndNote><Cite><Author>Lezak</Author><Year>2004</Year><RecNum>225</RecNum><DisplayText>(42)</DisplayText><record><rec-number>225</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr">225</key></foreign-keys><ref-type name="Book">6</ref-type><contributors><authors><author>Lezak, Muriel Deutsch</author><author>Howieson, Diane B.</author><author>Loring, David W.</author></authors></contributors><titles><title>Neuropsychological assessment</title></titles><edition>4th ed. / Muriel D. Lezak, Diane B. Howieson, David W. Loring with H. Julia Hannay and Jill S. Fischer.</edition><keywords><keyword>Neuropsychological tests.</keyword></keywords><dates><year>2004</year></dates><pub-location>Oxford</pub-location><publisher>Oxford University Press</publisher><isbn>0195111214 : ?59.50</isbn><call-num>616.80475 22
British Library HMNTS YC.2016.b.866
British Library DSC m04/29607</call-num><urls></urls></record></Cite></EndNote>(42). Cognitive functioning could be assessed subjectively using standardised questionnaires or single items (e.g. visual analogue scales), or objectively using cognitive tests. Studies utilising subjective measures of cognitive functioning were jointly inspected by all three authors (VH, SDK and DP) to consider if the subjective measure adequately assessed an aspect of cognitive functioning. A consensus was required for the study to be deemed as eligible.As the literature is limited, all types of treatment evaluation study designs were included. Studies were required to be written in English and published in peer-review journals.Quality AssessmentThe Downs and Black checklist ADDIN EN.CITE <EndNote><Cite><Author>Downs</Author><Year>1998</Year><RecNum>233</RecNum><DisplayText>(43)</DisplayText><record><rec-number>233</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr">233</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Downs, S. H.</author><author>Black, N.</author></authors></contributors><auth-address>Department of Public Health and Policy, London School of Hygiene and Tropical Medicine.</auth-address><titles><title>The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions</title><secondary-title>J Epidemiol Community Health</secondary-title><alt-title>Journal of epidemiology and community health</alt-title></titles><pages>377-84</pages><volume>52</volume><number>6</number><edition>1998/10/09</edition><keywords><keyword>Bias (Epidemiology)</keyword><keyword>Clinical Trials as Topic/*standards</keyword><keyword>Confounding Factors (Epidemiology)</keyword><keyword>Delivery of Health Care/*standards</keyword><keyword>Epidemiologic Studies</keyword><keyword>Feasibility Studies</keyword><keyword>Humans</keyword><keyword>Pilot Projects</keyword><keyword>*Quality Assurance, Health Care/organization & administration</keyword><keyword>Quality Control</keyword><keyword>Randomized Controlled Trials as Topic</keyword><keyword>Reproducibility of Results</keyword><keyword>Statistics, Nonparametric</keyword></keywords><dates><year>1998</year><pub-dates><date>Jun</date></pub-dates></dates><isbn>0143-005X (Print)
0143-005X (Linking)</isbn><accession-num>9764259</accession-num><urls><related-urls><url>;(43) was used to assess the methodological quality of included studies. It includes 27 items assessing study reporting, external validity, internal validity and power in relation to randomised and non-randomised studies. It has adequate levels of internal consistency, good inter-rater reliability and high test-retest reliability ADDIN EN.CITE <EndNote><Cite><Author>Downs</Author><Year>1998</Year><RecNum>233</RecNum><DisplayText>(43)</DisplayText><record><rec-number>233</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr">233</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Downs, S. H.</author><author>Black, N.</author></authors></contributors><auth-address>Department of Public Health and Policy, London School of Hygiene and Tropical Medicine.</auth-address><titles><title>The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions</title><secondary-title>J Epidemiol Community Health</secondary-title><alt-title>Journal of epidemiology and community health</alt-title></titles><pages>377-84</pages><volume>52</volume><number>6</number><edition>1998/10/09</edition><keywords><keyword>Bias (Epidemiology)</keyword><keyword>Clinical Trials as Topic/*standards</keyword><keyword>Confounding Factors (Epidemiology)</keyword><keyword>Delivery of Health Care/*standards</keyword><keyword>Epidemiologic Studies</keyword><keyword>Feasibility Studies</keyword><keyword>Humans</keyword><keyword>Pilot Projects</keyword><keyword>*Quality Assurance, Health Care/organization & administration</keyword><keyword>Quality Control</keyword><keyword>Randomized Controlled Trials as Topic</keyword><keyword>Reproducibility of Results</keyword><keyword>Statistics, Nonparametric</keyword></keywords><dates><year>1998</year><pub-dates><date>Jun</date></pub-dates></dates><isbn>0143-005X (Print)
0143-005X (Linking)</isbn><accession-num>9764259</accession-num><urls><related-urls><url>;(43). Item 27 relating to power was omitted due to the fact that cognitive functioning was a secondary outcome within the majority of the included studies and therefore power calculations were not based on this variable. Quality assessment was performed by two researchers independently, for three of the included studies. There was strong levels of agreement between the researchers (Kappa = .90).Data extraction Each article was read in full in order to extract and record details of the included studies within a standardised extraction form. This form included the following information: authors and year of published report, methods (study design, assessment time points, blinding, procedure for randomisation), participant characteristics (study population, sample size, age, gender distribution), intervention details (components and mode of delivery), information about the control or comparator intervention and outcomes on a measure of cognitive functioning. Data synthesisFindings were combined and summarised in a narrative synthesis. Factors which may explain differences in the direction or size of effects across studies (e.g. study methodology) were considered and discussed, as per guidelines for conducting narrative synthesis ADDIN EN.CITE <EndNote><Cite><Author>Popay</Author><Year>2006</Year><RecNum>239</RecNum><DisplayText>(44)</DisplayText><record><rec-number>239</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr">239</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Popay, J.</author><author>Roberts, H.</author><author>Sowden, A.</author><author>Petticrew, M.</author><author>Arai, L.</author><author>Rodgers, M.</author><author>Britten, N.</author><author>Roen, K.</author><author>Duffy, S.</author></authors></contributors><auth-address>University of Lancaster</auth-address><titles><title>Guidance on the conduct of narrative synthesis in systematic reviews: a product from the ESRC methods programme</title></titles><dates><year>2006</year></dates><orig-pub>University of Lancaster</orig-pub><urls></urls></record></Cite></EndNote>(44) . The SMD was used as a measure of effect size and was calculated for studies utilising a RCT design, providing the necessary post-treatment and follow-up data. Additional data was sought from authors where required. The SMD was derived by subtracting the mean for the control group from the mean for the treatment group and dividing the result by the pooled standard deviation. The direction of the values for the SMD was adjusted so that a positive value indicated better cognitive functioning in the treatment group compared to the control group at the post-treatment and follow-up time points. RESULTSStudy selectionSearches of databases and bibliographies yielded 2336 potentially relevant citations, of which 436 were duplicates and 1377 were deemed ineligible on the basis of title and abstract. Full text was retrieved for 523 studies and these papers were assessed against the inclusion and exclusion criteria. A final sample of 18 studies was included in the review. A flow chart of the study selection process is presented in figure 1.[Insert figure 1 here]Description of studies included within the reviewThere were a range of study designs within the included studies; 11 RCTs PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bcm5lZHQ8L0F1dGhvcj48WWVhcj4yMDExPC9ZZWFyPjxS
ZWNOdW0+MjQyPC9SZWNOdW0+PERpc3BsYXlUZXh0Pig0NS01NSk8L0Rpc3BsYXlUZXh0PjxyZWNv
cmQ+PHJlYy1udW1iZXI+MjQyPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVO
IiBkYi1pZD0iNXByd2U1c2Exc3oyc3BlZWZ3cjV0eDBveGR3OXN6enhwYXNyIj4yNDI8L2tleT48
L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5
cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkFybmVkdCwgSi4gVC48L2F1dGhvcj48
YXV0aG9yPkNvbnJveSwgRC4gQS48L2F1dGhvcj48YXV0aG9yPkFybWl0YWdlLCBSLjwvYXV0aG9y
PjxhdXRob3I+QnJvd2VyLCBLLiBKLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48
YXV0aC1hZGRyZXNzPlNsZWVwIGFuZCBDaHJvbm9waHlzaW9sb2d5IExhYm9yYXRvcnksIERlcGFy
dG1lbnQgb2YgUHN5Y2hpYXRyeSwgVW5pdmVyc2l0eSBvZiBNaWNoaWdhbiwgNDI1MCBQbHltb3V0
aCBSb2FkLCBBbm4gQXJib3IsIE1JIDQ4MTA5LTI3MDAsIFVTQS4gdGFybmVkdEBtZWQudW1pY2gu
ZWR1PC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+Q29nbml0aXZlLWJlaGF2aW9yYWwgdGhl
cmFweSBmb3IgaW5zb21uaWEgaW4gYWxjb2hvbCBkZXBlbmRlbnQgcGF0aWVudHM6IGEgcmFuZG9t
aXplZCBjb250cm9sbGVkIHBpbG90IHRyaWFsPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkJlaGF2
IFJlcyBUaGVyPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5CZWhhdmlvdXIgcmVzZWFyY2gg
YW5kIHRoZXJhcHk8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5C
ZWhhdiBSZXMgVGhlcjwvZnVsbC10aXRsZT48YWJici0xPkJlaGF2aW91ciByZXNlYXJjaCBhbmQg
dGhlcmFweTwvYWJici0xPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+
QmVoYXYgUmVzIFRoZXI8L2Z1bGwtdGl0bGU+PGFiYnItMT5CZWhhdmlvdXIgcmVzZWFyY2ggYW5k
IHRoZXJhcHk8L2FiYnItMT48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz4yMjctMzM8L3BhZ2VzPjx2
b2x1bWU+NDk8L3ZvbHVtZT48bnVtYmVyPjQ8L251bWJlcj48ZWRpdGlvbj4yMDExLzAzLzA4PC9l
ZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5BZHVsdDwva2V5d29yZD48a2V5d29yZD5BbGNvaG9s
aXNtLypjb21wbGljYXRpb25zPC9rZXl3b3JkPjxrZXl3b3JkPipDb2duaXRpdmUgVGhlcmFweTwv
a2V5d29yZD48a2V5d29yZD5GZW1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3Jk
PjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+TWlkZGxlIEFnZWQ8L2tleXdvcmQ+PGtl
eXdvcmQ+UGlsb3QgUHJvamVjdHM8L2tleXdvcmQ+PGtleXdvcmQ+UG9seXNvbW5vZ3JhcGh5PC9r
ZXl3b3JkPjxrZXl3b3JkPlNpbmdsZS1CbGluZCBNZXRob2Q8L2tleXdvcmQ+PGtleXdvcmQ+U2xl
ZXAgSW5pdGlhdGlvbiBhbmQgTWFpbnRlbmFuY2UgRGlzb3JkZXJzL2NvbXBsaWNhdGlvbnMvKnRo
ZXJhcHk8L2tleXdvcmQ+PGtleXdvcmQ+VHJlYXRtZW50IE91dGNvbWU8L2tleXdvcmQ+PC9rZXl3
b3Jkcz48ZGF0ZXM+PHllYXI+MjAxMTwveWVhcj48cHViLWRhdGVzPjxkYXRlPkFwcjwvZGF0ZT48
L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE4NzMtNjIyWCAoRWxlY3Ryb25pYykmI3hEOzAwMDUt
Nzk2NyAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MjEzNzcxNDQ8L2FjY2Vzc2lvbi1u
dW0+PHdvcmstdHlwZT5SYW5kb21pemVkIENvbnRyb2xsZWQgVHJpYWwmI3hEO1Jlc2VhcmNoIFN1
cHBvcnQsIE4uSS5ILiwgRXh0cmFtdXJhbDwvd29yay10eXBlPjx1cmxzPjxyZWxhdGVkLXVybHM+
PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzIxMzc3MTQ0PC91cmw+PC9y
ZWxhdGVkLXVybHM+PC91cmxzPjxjdXN0b20yPjMwNzM4MTE8L2N1c3RvbTI+PGVsZWN0cm9uaWMt
cmVzb3VyY2UtbnVtPjEwLjEwMTYvai5icmF0LjIwMTEuMDIuMDAzPC9lbGVjdHJvbmljLXJlc291
cmNlLW51bT48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1
dGhvcj5Bcm5lZHQ8L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFyPjxSZWNOdW0+MjkzPC9SZWNOdW0+
PHJlY29yZD48cmVjLW51bWJlcj4yOTM8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFw
cD0iRU4iIGRiLWlkPSI1cHJ3ZTVzYTFzejJzcGVlZndyNXR4MG94ZHc5c3p6eHBhc3IiPjI5Mzwv
a2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9y
ZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+QXJuZWR0LCBKLiBULjwvYXV0
aG9yPjxhdXRob3I+Q3VkZGloeSwgTC48L2F1dGhvcj48YXV0aG9yPlN3YW5zb24sIEwuIE0uPC9h
dXRob3I+PGF1dGhvcj5QaWNrZXR0LCBTLjwvYXV0aG9yPjxhdXRob3I+QWlrZW5zLCBKLjwvYXV0
aG9yPjxhdXRob3I+Q2hlcnZpbiwgUi4gRC48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRv
cnM+PGF1dGgtYWRkcmVzcz5TbGVlcCBhbmQgQ2hyb25vcGh5c2lvbG9neSBMYWJvcmF0b3J5LCBE
ZXBhcnRtZW50IG9mIFBzeWNoaWF0cnksIFVuaXZlcnNpdHkgb2YgTWljaGlnYW4sIEFubiBBcmJv
ciwgTUkgNDgxMDktMjcwMCwgVVNBLiB0YXJuZWR0QHVtaWNoLmVkdTwvYXV0aC1hZGRyZXNzPjx0
aXRsZXM+PHRpdGxlPlJhbmRvbWl6ZWQgY29udHJvbGxlZCB0cmlhbCBvZiB0ZWxlcGhvbmUtZGVs
aXZlcmVkIGNvZ25pdGl2ZSBiZWhhdmlvcmFsIHRoZXJhcHkgZm9yIGNocm9uaWMgaW5zb21uaWE8
L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+U2xlZXA8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxl
PlNsZWVwPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+U2xlZXA8
L2Z1bGwtdGl0bGU+PGFiYnItMT5TbGVlcDwvYWJici0xPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlv
ZGljYWw+PGZ1bGwtdGl0bGU+U2xlZXA8L2Z1bGwtdGl0bGU+PGFiYnItMT5TbGVlcDwvYWJici0x
PjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjM1My02MjwvcGFnZXM+PHZvbHVtZT4zNjwvdm9sdW1l
PjxudW1iZXI+MzwvbnVtYmVyPjxlZGl0aW9uPjIwMTMvMDMvMDI8L2VkaXRpb24+PGtleXdvcmRz
PjxrZXl3b3JkPkFjdGl2aXRpZXMgb2YgRGFpbHkgTGl2aW5nPC9rZXl3b3JkPjxrZXl3b3JkPkFk
dWx0PC9rZXl3b3JkPjxrZXl3b3JkPkNvZ25pdGl2ZSBUaGVyYXB5LyptZXRob2RzPC9rZXl3b3Jk
PjxrZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29yZD5Gb2xsb3ctVXAgU3R1ZGllczwva2V5
d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48a2V5
d29yZD5QYXRpZW50IENvbXBsaWFuY2U8L2tleXdvcmQ+PGtleXdvcmQ+U2xlZXA8L2tleXdvcmQ+
PGtleXdvcmQ+U2xlZXAgSW5pdGlhdGlvbiBhbmQgTWFpbnRlbmFuY2UgRGlzb3JkZXJzL3BzeWNo
b2xvZ3kvKnRoZXJhcHk8L2tleXdvcmQ+PGtleXdvcmQ+U3VydmV5cyBhbmQgUXVlc3Rpb25uYWly
ZXM8L2tleXdvcmQ+PGtleXdvcmQ+KlRlbGVwaG9uZTwva2V5d29yZD48a2V5d29yZD5UcmVhdG1l
bnQgT3V0Y29tZTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDEzPC95ZWFyPjxw
dWItZGF0ZXM+PGRhdGU+TWFyPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTU1MC05
MTA5IChFbGVjdHJvbmljKSYjeEQ7MDE2MS04MTA1IChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9u
LW51bT4yMzQ1MDcxMjwvYWNjZXNzaW9uLW51bT48d29yay10eXBlPlJhbmRvbWl6ZWQgQ29udHJv
bGxlZCBUcmlhbCYjeEQ7UmVzZWFyY2ggU3VwcG9ydCwgTi5JLkguLCBFeHRyYW11cmFsPC93b3Jr
LXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdv
di9wdWJtZWQvMjM0NTA3MTI8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGN1c3RvbTI+MzU3
MTc0NjwvY3VzdG9tMj48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuNTY2NS9zbGVlcC4yNDQ4
PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29y
ZD48L0NpdGU+PENpdGU+PEF1dGhvcj5DYXNhdWx0PC9BdXRob3I+PFllYXI+MjAxNTwvWWVhcj48
UmVjTnVtPjI1NTwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+MjU1PC9yZWMtbnVtYmVyPjxm
b3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iNXByd2U1c2Exc3oyc3BlZWZ3cjV0eDBv
eGR3OXN6enhwYXNyIj4yNTU8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91
cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9y
PkNhc2F1bHQsIEwuPC9hdXRob3I+PGF1dGhvcj5TYXZhcmQsIEouPC9hdXRob3I+PGF1dGhvcj5J
dmVycywgSC48L2F1dGhvcj48YXV0aG9yPlNhdmFyZCwgTS4gSC48L2F1dGhvcj48L2F1dGhvcnM+
PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5TY2hvb2wgb2YgUHN5Y2hvbG9neSwgVW5pdmVy
c2l0ZSBMYXZhbCwgUXVlYmVjLCBRdWViZWMsIEcxViAwQTYsIENhbmFkYTsgQ2VudHJlIGRlIHJl
Y2hlcmNoZSBkdSBDSFUgZGUgUXVlYmVjIGFuZCBDZW50cmUgZGUgcmVjaGVyY2hlIHN1ciBsZSBj
YW5jZXIsIFVuaXZlcnNpdGUgTGF2YWwsIDExIENvdGUgZHUgUGFsYWlzLCBRdWViZWMsIEcxUiAy
SjYsIENhbmFkYTsgQ2VudHJlIGhvc3BpdGFsaWVyIHVuaXZlcnNpdGFpcmUgKENIVSkgZGUgUXVl
YmVjLCAxMSwgQ290ZSBkdSBQYWxhaXMsIFF1ZWJlYywgUXVlYmVjLCBHMVIgMko2LCBDYW5hZGEu
JiN4RDtTY2hvb2wgb2YgUHN5Y2hvbG9neSwgVW5pdmVyc2l0ZSBMYXZhbCwgUXVlYmVjLCBRdWVi
ZWMsIEcxViAwQTYsIENhbmFkYTsgQ2VudHJlIGRlIHJlY2hlcmNoZSBkdSBDSFUgZGUgUXVlYmVj
IGFuZCBDZW50cmUgZGUgcmVjaGVyY2hlIHN1ciBsZSBjYW5jZXIsIFVuaXZlcnNpdGUgTGF2YWws
IDExIENvdGUgZHUgUGFsYWlzLCBRdWViZWMsIEcxUiAySjYsIENhbmFkYS4gRWxlY3Ryb25pYyBh
ZGRyZXNzOiBqb3NlZS5zYXZhcmRAcHN5LnVsYXZhbC5jYS4mI3hEO1NjaG9vbCBvZiBQc3ljaG9s
b2d5LCBVbml2ZXJzaXRlIExhdmFsLCBRdWViZWMsIFF1ZWJlYywgRzFWIDBBNiwgQ2FuYWRhOyBD
ZW50cmUgZGUgcmVjaGVyY2hlIGR1IENIVSBkZSBRdWViZWMgYW5kIENlbnRyZSBkZSByZWNoZXJj
aGUgc3VyIGxlIGNhbmNlciwgVW5pdmVyc2l0ZSBMYXZhbCwgMTEgQ290ZSBkdSBQYWxhaXMsIFF1
ZWJlYywgRzFSIDJKNiwgQ2FuYWRhLiYjeEQ7Q2VudHJlIGRlIHJlY2hlcmNoZSBkdSBDSFUgZGUg
UXVlYmVjIGFuZCBDZW50cmUgZGUgcmVjaGVyY2hlIHN1ciBsZSBjYW5jZXIsIFVuaXZlcnNpdGUg
TGF2YWwsIDExIENvdGUgZHUgUGFsYWlzLCBRdWViZWMsIEcxUiAySjYsIENhbmFkYS48L2F1dGgt
YWRkcmVzcz48dGl0bGVzPjx0aXRsZT5BIHJhbmRvbWl6ZWQtY29udHJvbGxlZCB0cmlhbCBvZiBh
biBlYXJseSBtaW5pbWFsIGNvZ25pdGl2ZS1iZWhhdmlvdXJhbCB0aGVyYXB5IGZvciBpbnNvbW5p
YSBjb21vcmJpZCB3aXRoIGNhbmNlcjwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5CZWhhdiBSZXMg
VGhlcjwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+QmVoYXZpb3VyIHJlc2VhcmNoIGFuZCB0
aGVyYXB5PC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+QmVoYXYg
UmVzIFRoZXI8L2Z1bGwtdGl0bGU+PGFiYnItMT5CZWhhdmlvdXIgcmVzZWFyY2ggYW5kIHRoZXJh
cHk8L2FiYnItMT48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkJlaGF2
IFJlcyBUaGVyPC9mdWxsLXRpdGxlPjxhYmJyLTE+QmVoYXZpb3VyIHJlc2VhcmNoIGFuZCB0aGVy
YXB5PC9hYmJyLTE+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+NDUtNTQ8L3BhZ2VzPjx2b2x1bWU+
Njc8L3ZvbHVtZT48ZWRpdGlvbj4yMDE1LzAzLzEwPC9lZGl0aW9uPjxkYXRlcz48eWVhcj4yMDE1
PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+QXByPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlz
Ym4+MTg3My02MjJYIChFbGVjdHJvbmljKSYjeEQ7MDAwNS03OTY3IChMaW5raW5nKTwvaXNibj48
YWNjZXNzaW9uLW51bT4yNTc0Njc3NzwvYWNjZXNzaW9uLW51bT48d29yay10eXBlPlJlc2VhcmNo
IFN1cHBvcnQsIE5vbi1VLlMuIEdvdiZhcG9zO3Q8L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11
cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8yNTc0Njc3NzwvdXJs
PjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTAxNi9q
LmJyYXQuMjAxNS4wMi4wMDM8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjxsYW5ndWFnZT5lbmc8
L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPkphbnNzb248L0F1dGhvcj48
WWVhcj4yMDA1PC9ZZWFyPjxSZWNOdW0+MjYzPC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj4y
NjM8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSI1cHJ3ZTVz
YTFzejJzcGVlZndyNXR4MG94ZHc5c3p6eHBhc3IiPjI2Mzwva2V5PjwvZm9yZWlnbi1rZXlzPjxy
ZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3Jz
PjxhdXRob3JzPjxhdXRob3I+SmFuc3NvbiwgTS48L2F1dGhvcj48YXV0aG9yPkxpbnRvbiwgUy4g
Si48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5EZXBhcnRt
ZW50IG9mIE9jY3VwYXRpb25hbCBhbmQgRW52aXJvbm1lbnRhbCBNZWRpY2luZSwgT3JlYnJvIE1l
ZGljYWwgQ2VudGVyLCBTLTcwMSA4NSBPcmVicm8sIFN3ZWRlbi48L2F1dGgtYWRkcmVzcz48dGl0
bGVzPjx0aXRsZT5Db2duaXRpdmUtYmVoYXZpb3JhbCBncm91cCB0aGVyYXB5IGFzIGFuIGVhcmx5
IGludGVydmVudGlvbiBmb3IgaW5zb21uaWE6IGEgcmFuZG9taXplZCBjb250cm9sbGVkIHRyaWFs
PC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkogT2NjdXAgUmVoYWJpbDwvc2Vjb25kYXJ5LXRpdGxl
PjxhbHQtdGl0bGU+Sm91cm5hbCBvZiBvY2N1cGF0aW9uYWwgcmVoYWJpbGl0YXRpb248L2FsdC10
aXRsZT48L3RpdGxlcz48YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+Sm91cm5hbCBvZiBPY2N1
cGF0aW9uYWwgUmVoYWJpbGl0YXRpb248L2Z1bGwtdGl0bGU+PC9hbHQtcGVyaW9kaWNhbD48cGFn
ZXM+MTc3LTkwPC9wYWdlcz48dm9sdW1lPjE1PC92b2x1bWU+PG51bWJlcj4yPC9udW1iZXI+PGVk
aXRpb24+MjAwNS8wNC8yMzwvZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QWRvbGVzY2VudDwv
a2V5d29yZD48a2V5d29yZD5BZHVsdDwva2V5d29yZD48a2V5d29yZD5BZ2VkPC9rZXl3b3JkPjxr
ZXl3b3JkPkFueGlldHk8L2tleXdvcmQ+PGtleXdvcmQ+QXR0aXR1ZGUgdG8gSGVhbHRoPC9rZXl3
b3JkPjxrZXl3b3JkPipDb2duaXRpdmUgVGhlcmFweTwva2V5d29yZD48a2V5d29yZD5EZXByZXNz
aW9uPC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29yZD5Gb2xsb3ctVXAg
U3R1ZGllczwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwv
a2V5d29yZD48a2V5d29yZD5NaWRkbGUgQWdlZDwva2V5d29yZD48a2V5d29yZD4qUGF0aWVudCBF
ZHVjYXRpb24gYXMgVG9waWM8L2tleXdvcmQ+PGtleXdvcmQ+KlBzeWNob3RoZXJhcHksIEdyb3Vw
PC9rZXl3b3JkPjxrZXl3b3JkPlNsZWVwIEluaXRpYXRpb24gYW5kIE1haW50ZW5hbmNlIERpc29y
ZGVycy9waHlzaW9wYXRob2xvZ3kvKnRoZXJhcHk8L2tleXdvcmQ+PGtleXdvcmQ+U3VydmV5cyBh
bmQgUXVlc3Rpb25uYWlyZXM8L2tleXdvcmQ+PGtleXdvcmQ+VGVhY2hpbmcgTWF0ZXJpYWxzL3N1
cHBseSAmYW1wOyBkaXN0cmlidXRpb248L2tleXdvcmQ+PGtleXdvcmQ+VGltZSBGYWN0b3JzPC9r
ZXl3b3JkPjxrZXl3b3JkPlRyZWF0bWVudCBPdXRjb21lPC9rZXl3b3JkPjwva2V5d29yZHM+PGRh
dGVzPjx5ZWFyPjIwMDU8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5KdW48L2RhdGU+PC9wdWItZGF0
ZXM+PC9kYXRlcz48aXNibj4xMDUzLTA0ODcgKFByaW50KSYjeEQ7MTA1My0wNDg3IChMaW5raW5n
KTwvaXNibj48YWNjZXNzaW9uLW51bT4xNTg0NDY3NTwvYWNjZXNzaW9uLW51bT48d29yay10eXBl
PkNsaW5pY2FsIFRyaWFsJiN4RDtSYW5kb21pemVkIENvbnRyb2xsZWQgVHJpYWwmI3hEO1Jlc2Vh
cmNoIFN1cHBvcnQsIE5vbi1VLlMuIEdvdiZhcG9zO3Q8L3dvcmstdHlwZT48dXJscz48cmVsYXRl
ZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8xNTg0NDY3NTwv
dXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29y
ZD48L0NpdGU+PENpdGU+PEF1dGhvcj5NYXR0aGV3czwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+
PFJlY051bT4yNjc8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjI2NzwvcmVjLW51bWJlcj48
Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9IjVwcndlNXNhMXN6MnNwZWVmd3I1dHgw
b3hkdzlzenp4cGFzciI+MjY3PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9Ikpv
dXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhv
cj5NYXR0aGV3cywgRS4gRS48L2F1dGhvcj48YXV0aG9yPkJlcmdlciwgQS4gTS48L2F1dGhvcj48
YXV0aG9yPlNjaG1pZWdlLCBTLiBKLjwvYXV0aG9yPjxhdXRob3I+Q29vaywgUC4gRi48L2F1dGhv
cj48YXV0aG9yPk1jQ2FydGh5LCBNLiBTLjwvYXV0aG9yPjxhdXRob3I+TW9vcmUsIEMuIE0uPC9h
dXRob3I+PGF1dGhvcj5BbG9pYSwgTS4gUy48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRv
cnM+PGF1dGgtYWRkcmVzcz5Db2xsZWdlIG9mIE51cnNpbmcsIFVuaXZlcnNpdHkgb2YgQ29sb3Jh
ZG8gaW4gQXVyb3JhLiYjeEQ7Q29sbGVnZSBvZiBOdXJzaW5nLCBPbWFoYSBEaXZpc2lvbiwgVW5p
dmVyc2l0eSBvZiBOZWJyYXNrYSBNZWRpY2FsIENlbnRlci4mI3hEO0RlcGFydG1lbnQgb2YgQmlv
c3RhdGlzdGljcyBhbmQgSW5mb3JtYXRpY3MsIFNjaG9vbCBvZiBQdWJsaWMgSGVhbHRoLiYjeEQ7
Q29sbGVnZSBvZiBOdXJzaW5nLCBVbml2ZXJzaXR5IG9mIENvbG9yYWRvIGluIERlbnZlci4mI3hE
O0RlcGFydG1lbnQgb2YgQmlvc3RhdGlzdGljcyBhbmQgSW5mb3JtYXRpY3MgaW4gdGhlIFNjaG9v
bCBvZiBQdWJsaWMgSGVhbHRoLCBVbml2ZXJzaXR5IG9mIENvbG9yYWRvIGluIERlbnZlci4mI3hE
O05hdGlvbmFsIEpld2lzaCBIZWFsdGgsIERlbnZlciwgQ08uPC9hdXRoLWFkZHJlc3M+PHRpdGxl
cz48dGl0bGU+Q29nbml0aXZlIGJlaGF2aW9yYWwgdGhlcmFweSBmb3IgaW5zb21uaWEgb3V0Y29t
ZXMgaW4gd29tZW4gYWZ0ZXIgcHJpbWFyeSBicmVhc3QgY2FuY2VyIHRyZWF0bWVudDogYSByYW5k
b21pemVkLCBjb250cm9sbGVkIHRyaWFsPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPk9uY29sIE51
cnMgRm9ydW08L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPk9uY29sb2d5IG51cnNpbmcgZm9y
dW08L2FsdC10aXRsZT48L3RpdGxlcz48cGFnZXM+MjQxLTUzPC9wYWdlcz48dm9sdW1lPjQxPC92
b2x1bWU+PG51bWJlcj4zPC9udW1iZXI+PGVkaXRpb24+MjAxNC8wMy8yMjwvZWRpdGlvbj48a2V5
d29yZHM+PGtleXdvcmQ+QWR1bHQ8L2tleXdvcmQ+PGtleXdvcmQ+QWdlZDwva2V5d29yZD48a2V5
d29yZD5CcmVhc3QgTmVvcGxhc21zLypjb21wbGljYXRpb25zPC9rZXl3b3JkPjxrZXl3b3JkPipD
b2duaXRpdmUgVGhlcmFweTwva2V5d29yZD48a2V5d29yZD5Db2xvcmFkbzwva2V5d29yZD48a2V5
d29yZD5GZW1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPkxv
bmdpdHVkaW5hbCBTdHVkaWVzPC9rZXl3b3JkPjxrZXl3b3JkPk1pZGRsZSBBZ2VkPC9rZXl3b3Jk
PjxrZXl3b3JkPlBlcmlvcGVyYXRpdmUgUGVyaW9kPC9rZXl3b3JkPjxrZXl3b3JkPlByb3NwZWN0
aXZlIFN0dWRpZXM8L2tleXdvcmQ+PGtleXdvcmQ+UXVhbGl0eSBvZiBMaWZlPC9rZXl3b3JkPjxr
ZXl3b3JkPlNsZWVwIEluaXRpYXRpb24gYW5kIE1haW50ZW5hbmNlIERpc29yZGVycy9ldGlvbG9n
eS8qdGhlcmFweTwva2V5d29yZD48a2V5d29yZD4qU3Vydml2b3JzPC9rZXl3b3JkPjxrZXl3b3Jk
PlRyZWF0bWVudCBPdXRjb21lPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTQ8
L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5NYXk8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNi
bj4xNTM4LTA2ODggKEVsZWN0cm9uaWMpJiN4RDswMTkwLTUzNVggKExpbmtpbmcpPC9pc2JuPjxh
Y2Nlc3Npb24tbnVtPjI0NjUwODMyPC9hY2Nlc3Npb24tbnVtPjx3b3JrLXR5cGU+UmFuZG9taXpl
ZCBDb250cm9sbGVkIFRyaWFsJiN4RDtSZXNlYXJjaCBTdXBwb3J0LCBOLkkuSC4sIEV4dHJhbXVy
YWw8L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5s
bS5uaWguZ292L3B1Ym1lZC8yNDY1MDgzMjwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxl
Y3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTE4OC8xNC5PTkYuNDEtMDNBUDwvZWxlY3Ryb25pYy1y
ZXNvdXJjZS1udW0+PGxhbmd1YWdlPmVuZzwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9DaXRlPjxDaXRl
PjxBdXRob3I+TWlybzwvQXV0aG9yPjxZZWFyPjIwMTE8L1llYXI+PFJlY051bT4yNzE8L1JlY051
bT48cmVjb3JkPjxyZWMtbnVtYmVyPjI3MTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkg
YXBwPSJFTiIgZGItaWQ9IjVwcndlNXNhMXN6MnNwZWVmd3I1dHgwb3hkdzlzenp4cGFzciI+Mjcx
PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8
L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5NaXJvLCBFLjwvYXV0aG9y
PjxhdXRob3I+THVwaWFuZXosIEouPC9hdXRob3I+PGF1dGhvcj5NYXJ0aW5leiwgTS4gUC48L2F1
dGhvcj48YXV0aG9yPlNhbmNoZXosIEEuIEkuPC9hdXRob3I+PGF1dGhvcj5EaWF6LVBpZWRyYSwg
Qy48L2F1dGhvcj48YXV0aG9yPkd1em1hbiwgTS4gQS48L2F1dGhvcj48YXV0aG9yPkJ1ZWxhLUNh
c2FsLCBHLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPlVu
aXZlcnNpZGFkIGRlIEdyYW5hZGEsIENhbXB1cyBVbml2ZXJzaXRhcmlvIGRlIGxhIENhcnR1amEs
IHMvbiwgQ1AuIDE4MDcxLCBHcmFuYWRhLCBTcGFpbi4gZW1pcm9AdWdyLmU8L2F1dGgtYWRkcmVz
cz48dGl0bGVzPjx0aXRsZT5Db2duaXRpdmUtYmVoYXZpb3JhbCB0aGVyYXB5IGZvciBpbnNvbW5p
YSBpbXByb3ZlcyBhdHRlbnRpb25hbCBmdW5jdGlvbiBpbiBmaWJyb215YWxnaWEgc3luZHJvbWU6
IGEgcGlsb3QsIHJhbmRvbWl6ZWQgY29udHJvbGxlZCB0cmlhbDwvdGl0bGU+PHNlY29uZGFyeS10
aXRsZT5KIEhlYWx0aCBQc3ljaG9sPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5Kb3VybmFs
IG9mIGhlYWx0aCBwc3ljaG9sb2d5PC9hbHQtdGl0bGU+PC90aXRsZXM+PHBhZ2VzPjc3MC04Mjwv
cGFnZXM+PHZvbHVtZT4xNjwvdm9sdW1lPjxudW1iZXI+NTwvbnVtYmVyPjxlZGl0aW9uPjIwMTEv
MDIvMjU8L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFjdGl2aXRpZXMgb2YgRGFpbHkgTGl2
aW5nL3BzeWNob2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+QWR1bHQ8L2tleXdvcmQ+PGtleXdvcmQ+
QXR0ZW50aW9uPC9rZXl3b3JkPjxrZXl3b3JkPipDb2duaXRpdmUgVGhlcmFweS9tZXRob2RzPC9r
ZXl3b3JkPjxrZXl3b3JkPkV4ZWN1dGl2ZSBGdW5jdGlvbjwva2V5d29yZD48a2V5d29yZD5GZW1h
bGU8L2tleXdvcmQ+PGtleXdvcmQ+Rmlicm9teWFsZ2lhL2NvbXBsaWNhdGlvbnMvcHN5Y2hvbG9n
eS8qdGhlcmFweTwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+TWlk
ZGxlIEFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+TmV1cm9wc3ljaG9sb2dpY2FsIFRlc3RzPC9rZXl3
b3JkPjxrZXl3b3JkPlBpbG90IFByb2plY3RzPC9rZXl3b3JkPjxrZXl3b3JkPlNsZWVwPC9rZXl3
b3JkPjxrZXl3b3JkPlNsZWVwIEluaXRpYXRpb24gYW5kIE1haW50ZW5hbmNlIERpc29yZGVycy9j
b21wbGljYXRpb25zL3BzeWNob2xvZ3kvKnRoZXJhcHk8L2tleXdvcmQ+PGtleXdvcmQ+U3VydmV5
cyBhbmQgUXVlc3Rpb25uYWlyZXM8L2tleXdvcmQ+PGtleXdvcmQ+VHJlYXRtZW50IE91dGNvbWU8
L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxMTwveWVhcj48cHViLWRhdGVzPjxk
YXRlPkp1bDwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE0NjEtNzI3NyAoRWxlY3Ry
b25pYykmI3hEOzEzNTktMTA1MyAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MjEzNDYw
MjA8L2FjY2Vzc2lvbi1udW0+PHdvcmstdHlwZT5SYW5kb21pemVkIENvbnRyb2xsZWQgVHJpYWwm
I3hEO1Jlc2VhcmNoIFN1cHBvcnQsIE5vbi1VLlMuIEdvdiZhcG9zO3Q8L3dvcmstdHlwZT48dXJs
cz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8y
MTM0NjAyMDwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1u
dW0+MTAuMTE3Ny8xMzU5MTA1MzEwMzkwNTQ0PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48bGFu
Z3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5PbXZpazwv
QXV0aG9yPjxZZWFyPjIwMDg8L1llYXI+PFJlY051bT4yNzI8L1JlY051bT48cmVjb3JkPjxyZWMt
bnVtYmVyPjI3MjwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9
IjVwcndlNXNhMXN6MnNwZWVmd3I1dHgwb3hkdzlzenp4cGFzciI+MjcyPC9rZXk+PC9mb3JlaWdu
LWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250
cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5PbXZpaywgUy48L2F1dGhvcj48YXV0aG9yPlNpdmVy
dHNlbiwgQi48L2F1dGhvcj48YXV0aG9yPlBhbGxlc2VuLCBTLjwvYXV0aG9yPjxhdXRob3I+Qmpv
cnZhdG4sIEIuPC9hdXRob3I+PGF1dGhvcj5IYXZpaywgTy4gRS48L2F1dGhvcj48YXV0aG9yPk5v
cmRodXMsIEkuIEguPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJl
c3M+RGVwYXJ0bWVudCBvZiBDbGluaWNhbCBQc3ljaG9sb2d5LCBVbml2ZXJzaXR5IG9mIEJlcmdl
biwgQmVyZ2VuLCBOb3J3YXkuIHNpcmkub212aWtAcHN5a3AudWliLm5vPC9hdXRoLWFkZHJlc3M+
PHRpdGxlcz48dGl0bGU+RGF5dGltZSBmdW5jdGlvbmluZyBpbiBvbGRlciBwYXRpZW50cyBzdWZm
ZXJpbmcgZnJvbSBjaHJvbmljIGluc29tbmlhOiB0cmVhdG1lbnQgb3V0Y29tZSBpbiBhIHJhbmRv
bWl6ZWQgY29udHJvbGxlZCB0cmlhbCBjb21wYXJpbmcgQ0JUIHdpdGggWm9waWNsb25lPC90aXRs
ZT48c2Vjb25kYXJ5LXRpdGxlPkJlaGF2IFJlcyBUaGVyPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10
aXRsZT5CZWhhdmlvdXIgcmVzZWFyY2ggYW5kIHRoZXJhcHk8L2FsdC10aXRsZT48L3RpdGxlcz48
cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5CZWhhdiBSZXMgVGhlcjwvZnVsbC10aXRsZT48YWJici0x
PkJlaGF2aW91ciByZXNlYXJjaCBhbmQgdGhlcmFweTwvYWJici0xPjwvcGVyaW9kaWNhbD48YWx0
LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+QmVoYXYgUmVzIFRoZXI8L2Z1bGwtdGl0bGU+PGFiYnIt
MT5CZWhhdmlvdXIgcmVzZWFyY2ggYW5kIHRoZXJhcHk8L2FiYnItMT48L2FsdC1wZXJpb2RpY2Fs
PjxwYWdlcz42MjMtNDE8L3BhZ2VzPjx2b2x1bWU+NDY8L3ZvbHVtZT48bnVtYmVyPjU8L251bWJl
cj48ZWRpdGlvbj4yMDA4LzA0LzE4PC9lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5BZ2VkPC9r
ZXl3b3JkPjxrZXl3b3JkPkF6YWJpY3ljbG8gQ29tcG91bmRzLyp0aGVyYXBldXRpYyB1c2U8L2tl
eXdvcmQ+PGtleXdvcmQ+KkNvZ25pdGl2ZSBUaGVyYXB5PC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFs
ZTwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+SHlwbm90aWNzIGFu
ZCBTZWRhdGl2ZXMvKnRoZXJhcGV1dGljIHVzZTwva2V5d29yZD48a2V5d29yZD5NYWxlPC9rZXl3
b3JkPjxrZXl3b3JkPk1pZGRsZSBBZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPlBpcGVyYXppbmVzLyp0
aGVyYXBldXRpYyB1c2U8L2tleXdvcmQ+PGtleXdvcmQ+UHN5Y2hpYXRyaWMgU3RhdHVzIFJhdGlu
ZyBTY2FsZXM8L2tleXdvcmQ+PGtleXdvcmQ+UXVhbGl0eSBvZiBMaWZlPC9rZXl3b3JkPjxrZXl3
b3JkPlNsZWVwIEluaXRpYXRpb24gYW5kIE1haW50ZW5hbmNlIERpc29yZGVycy8qdGhlcmFweTwv
a2V5d29yZD48a2V5d29yZD5UcmVhdG1lbnQgT3V0Y29tZTwva2V5d29yZD48L2tleXdvcmRzPjxk
YXRlcz48eWVhcj4yMDA4PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+TWF5PC9kYXRlPjwvcHViLWRh
dGVzPjwvZGF0ZXM+PGlzYm4+MDAwNS03OTY3IChQcmludCkmI3hEOzAwMDUtNzk2NyAoTGlua2lu
Zyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MTg0MTcwOTk8L2FjY2Vzc2lvbi1udW0+PHdvcmstdHlw
ZT5Db21wYXJhdGl2ZSBTdHVkeSYjeEQ7UmFuZG9taXplZCBDb250cm9sbGVkIFRyaWFsJiN4RDtS
ZXNlYXJjaCBTdXBwb3J0LCBOb24tVS5TLiBHb3YmYXBvczt0PC93b3JrLXR5cGU+PHVybHM+PHJl
bGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMTg0MTcw
OTk8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEw
LjEwMTYvai5icmF0LjIwMDguMDIuMDEzPC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48bGFuZ3Vh
Z2U+ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5SaXR0ZXJiYW5k
PC9BdXRob3I+PFllYXI+MjAxMjwvWWVhcj48UmVjTnVtPjI3NzwvUmVjTnVtPjxyZWNvcmQ+PHJl
Yy1udW1iZXI+Mjc3PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1p
ZD0iNXByd2U1c2Exc3oyc3BlZWZ3cjV0eDBveGR3OXN6enhwYXNyIj4yNzc8L2tleT48L2ZvcmVp
Z24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNv
bnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPlJpdHRlcmJhbmQsIEwuIE0uPC9hdXRob3I+PGF1
dGhvcj5CYWlsZXksIEUuIFQuPC9hdXRob3I+PGF1dGhvcj5UaG9ybmRpa2UsIEYuIFAuPC9hdXRo
b3I+PGF1dGhvcj5Mb3JkLCBILiBSLjwvYXV0aG9yPjxhdXRob3I+RmFycmVsbC1DYXJuYWhhbiwg
TC48L2F1dGhvcj48YXV0aG9yPkJhdW0sIEwuIEQuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJp
YnV0b3JzPjxhdXRoLWFkZHJlc3M+RGVwYXJ0bWVudCBvZiBQc3ljaGlhdHJ5IGFuZCBOZXVyb2Jl
aGF2aW9yYWwgU2NpZW5jZXMsIFVuaXZlcnNpdHkgb2YgVmlyZ2luaWEgSGVhbHRoIFN5c3RlbSwg
Q2hhcmxvdHRlc3ZpbGxlLCBWQSAyMjkwOCwgVVNBLiBsZWVyQHZpcmdpbmlhLmVkdTwvYXV0aC1h
ZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkluaXRpYWwgZXZhbHVhdGlvbiBvZiBhbiBJbnRlcm5ldCBp
bnRlcnZlbnRpb24gdG8gaW1wcm92ZSB0aGUgc2xlZXAgb2YgY2FuY2VyIHN1cnZpdm9ycyB3aXRo
IGluc29tbmlhPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPlBzeWNob29uY29sb2d5PC9zZWNvbmRh
cnktdGl0bGU+PGFsdC10aXRsZT5Qc3ljaG8tb25jb2xvZ3k8L2FsdC10aXRsZT48L3RpdGxlcz48
cGFnZXM+Njk1LTcwNTwvcGFnZXM+PHZvbHVtZT4yMTwvdm9sdW1lPjxudW1iZXI+NzwvbnVtYmVy
PjxlZGl0aW9uPjIwMTEvMDUvMDQ8L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFkdWx0PC9r
ZXl3b3JkPjxrZXl3b3JkPkNvZ25pdGl2ZSBUaGVyYXB5LyptZXRob2RzPC9rZXl3b3JkPjxrZXl3
b3JkPkZhdGlndWUvcHN5Y2hvbG9neS90aGVyYXB5PC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFsZTwv
a2V5d29yZD48a2V5d29yZD5Gb2xsb3ctVXAgU3R1ZGllczwva2V5d29yZD48a2V5d29yZD5IdW1h
bnM8L2tleXdvcmQ+PGtleXdvcmQ+KkludGVybmV0PC9rZXl3b3JkPjxrZXl3b3JkPk1hbGU8L2tl
eXdvcmQ+PGtleXdvcmQ+TWlkZGxlIEFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+TmVvcGxhc21zLypj
b21wbGljYXRpb25zL3BzeWNob2xvZ3kvKnRoZXJhcHk8L2tleXdvcmQ+PGtleXdvcmQ+UGF0aWVu
dCBFZHVjYXRpb24gYXMgVG9waWMvbWV0aG9kczwva2V5d29yZD48a2V5d29yZD5RdWFsaXR5IG9m
IExpZmUvcHN5Y2hvbG9neTwva2V5d29yZD48a2V5d29yZD5TZXZlcml0eSBvZiBJbGxuZXNzIElu
ZGV4PC9rZXl3b3JkPjxrZXl3b3JkPlNsZWVwIEluaXRpYXRpb24gYW5kIE1haW50ZW5hbmNlIERp
c29yZGVycy8qZXRpb2xvZ3kvcHN5Y2hvbG9neS8qdGhlcmFweTwva2V5d29yZD48a2V5d29yZD5T
dHJlc3MsIFBzeWNob2xvZ2ljYWw8L2tleXdvcmQ+PGtleXdvcmQ+U3Vydml2b3JzLypwc3ljaG9s
b2d5PC9rZXl3b3JkPjxrZXl3b3JkPlRoZXJhcHksIENvbXB1dGVyLUFzc2lzdGVkLyptZXRob2Rz
PC9rZXl3b3JkPjxrZXl3b3JkPlRyZWF0bWVudCBPdXRjb21lPC9rZXl3b3JkPjwva2V5d29yZHM+
PGRhdGVzPjx5ZWFyPjIwMTI8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5KdWw8L2RhdGU+PC9wdWIt
ZGF0ZXM+PC9kYXRlcz48aXNibj4xMDk5LTE2MTEgKEVsZWN0cm9uaWMpJiN4RDsxMDU3LTkyNDkg
KExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjIxNTM4Njc4PC9hY2Nlc3Npb24tbnVtPjx3
b3JrLXR5cGU+UmFuZG9taXplZCBDb250cm9sbGVkIFRyaWFsJiN4RDtSZXNlYXJjaCBTdXBwb3J0
LCBOLkkuSC4sIEV4dHJhbXVyYWwmI3hEO1Jlc2VhcmNoIFN1cHBvcnQsIE5vbi1VLlMuIEdvdiZh
cG9zO3Q8L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2Jp
Lm5sbS5uaWguZ292L3B1Ym1lZC8yMTUzODY3ODwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48
Y3VzdG9tMj4zNDI0MjcwPC9jdXN0b20yPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMDAy
L3Bvbi4xOTY5PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFn
ZT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5TdW48L0F1dGhvcj48WWVhcj4yMDEzPC9Z
ZWFyPjxSZWNOdW0+MjgwPC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj4yODA8L3JlYy1udW1i
ZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSI1cHJ3ZTVzYTFzejJzcGVlZndy
NXR4MG94ZHc5c3p6eHBhc3IiPjI4MDwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1l
PSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxh
dXRob3I+U3VuLCBKLjwvYXV0aG9yPjxhdXRob3I+S2FuZywgSi48L2F1dGhvcj48YXV0aG9yPldh
bmcsIFAuPC9hdXRob3I+PGF1dGhvcj5aZW5nLCBILjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRy
aWJ1dG9ycz48YXV0aC1hZGRyZXNzPlNjaG9vbCBvZiBOdXJzaW5nLCBDZW50cmFsIFNvdXRoIFVu
aXZlcnNpdHksIENoYW5nc2hhLCBIdW5hbiBQcm92aW5jZSwgQ2hpbmEuPC9hdXRoLWFkZHJlc3M+
PHRpdGxlcz48dGl0bGU+U2VsZi1yZWxheGF0aW9uIHRyYWluaW5nIGNhbiBpbXByb3ZlIHNsZWVw
IHF1YWxpdHkgYW5kIGNvZ25pdGl2ZSBmdW5jdGlvbnMgaW4gdGhlIG9sZGVyOiBhIG9uZS15ZWFy
IHJhbmRvbWlzZWQgY29udHJvbGxlZCB0cmlhbDwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5KIENs
aW4gTnVyczwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+Sm91cm5hbCBvZiBjbGluaWNhbCBu
dXJzaW5nPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBhZ2VzPjEyNzAtODA8L3BhZ2VzPjx2b2x1bWU+
MjI8L3ZvbHVtZT48bnVtYmVyPjktMTA8L251bWJlcj48ZWRpdGlvbj4yMDEzLzA0LzEyPC9lZGl0
aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5BZG9sZXNjZW50PC9rZXl3b3JkPjxrZXl3b3JkPkFkdWx0
PC9rZXl3b3JkPjxrZXl3b3JkPkFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+QWdlZCwgODAgYW5kIG92
ZXI8L2tleXdvcmQ+PGtleXdvcmQ+QW5hbHlzaXMgb2YgVmFyaWFuY2U8L2tleXdvcmQ+PGtleXdv
cmQ+Q2hpbGQ8L2tleXdvcmQ+PGtleXdvcmQ+KkNvZ25pdGlvbjwva2V5d29yZD48a2V5d29yZD5G
ZW1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPk1hbGU8L2tl
eXdvcmQ+PGtleXdvcmQ+TWlkZGxlIEFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+UGF0aWVudCBFZHVj
YXRpb24gYXMgVG9waWMvKm1ldGhvZHM8L2tleXdvcmQ+PGtleXdvcmQ+KlJlbGF4YXRpb24gVGhl
cmFweTwva2V5d29yZD48a2V5d29yZD4qU2VsZiBDYXJlPC9rZXl3b3JkPjxrZXl3b3JkPipTbGVl
cDwva2V5d29yZD48a2V5d29yZD5TdXJ2ZXlzIGFuZCBRdWVzdGlvbm5haXJlczwva2V5d29yZD48
a2V5d29yZD5Zb3VuZyBBZHVsdDwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDEz
PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+TWF5PC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlz
Ym4+MTM2NS0yNzAyIChFbGVjdHJvbmljKSYjeEQ7MDk2Mi0xMDY3IChMaW5raW5nKTwvaXNibj48
YWNjZXNzaW9uLW51bT4yMzU3NDI5MDwvYWNjZXNzaW9uLW51bT48d29yay10eXBlPlJhbmRvbWl6
ZWQgQ29udHJvbGxlZCBUcmlhbCYjeEQ7UmVzZWFyY2ggU3VwcG9ydCwgTm9uLVUuUy4gR292JmFw
b3M7dDwvd29yay10eXBlPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5jYmku
bmxtLm5paC5nb3YvcHVibWVkLzIzNTc0MjkwPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxl
bGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMTExL2pvY24uMTIwOTY8L2VsZWN0cm9uaWMtcmVz
b3VyY2UtbnVtPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48
QXV0aG9yPlRheWxvcjwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+PFJlY051bT4yODQ8L1JlY051
bT48cmVjb3JkPjxyZWMtbnVtYmVyPjI4NDwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkg
YXBwPSJFTiIgZGItaWQ9IjVwcndlNXNhMXN6MnNwZWVmd3I1dHgwb3hkdzlzenp4cGFzciI+Mjg0
PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8
L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5UYXlsb3IsIEQuIEouPC9h
dXRob3I+PGF1dGhvcj5aaW1tZXJtYW4sIE0uIFIuPC9hdXRob3I+PGF1dGhvcj5HYXJkbmVyLCBD
LiBFLjwvYXV0aG9yPjxhdXRob3I+V2lsbGlhbXMsIEouIE0uPC9hdXRob3I+PGF1dGhvcj5Hcmll
c2VyLCBFLiBBLjwvYXV0aG9yPjxhdXRob3I+VGF0dW0sIEouIEkuPC9hdXRob3I+PGF1dGhvcj5C
cmFtb3dldGgsIEEuIEQuPC9hdXRob3I+PGF1dGhvcj5GcmFuY2V0aWNoLCBKLiBNLjwvYXV0aG9y
PjxhdXRob3I+UnVnZ2VybywgQy48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1
dGgtYWRkcmVzcz5Vbml2ZXJzaXR5IG9mIE5vcnRoIFRleGFzLiBFbGVjdHJvbmljIGFkZHJlc3M6
IGRqdGF5bG9yQHVudC5lZHUuJiN4RDtVbml2ZXJzaXR5IG9mIE5vcnRoIFRleGFzLiYjeEQ7VGV4
YXMgVGVjaCBVbml2ZXJzaXR5LiYjeEQ7VGhlIFVuaXZlcnNpdHkgb2YgVGV4YXMgSGVhbHRoIFNj
aWVuY2UgQ2VudGVyIGF0IFNhbiBBbnRvbmlvLiYjeEQ7V2lsZm9yZCBIYWxsIEFtYnVsYXRvcnkg
U3VyZ2ljYWwgQ2VudGVyLiYjeEQ7V3JpZ2h0LVBhdHRlcnNvbiBNZWRpY2FsIENlbnRlci4mI3hE
O1ZBIFBpdHRzYnVyZ2ggSGVhbHRoY2FyZSBTeXN0ZW0uJiN4RDtVbml2ZXJzaXR5IG9mIE5vcnRo
IFRleGFzLCBEZXBhcnRtZW50IG9mIFBzeWNob2xvZ3kuPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48
dGl0bGU+QSBwaWxvdCByYW5kb21pemVkIGNvbnRyb2xsZWQgdHJpYWwgb2YgdGhlIGVmZmVjdHMg
b2YgY29nbml0aXZlLWJlaGF2aW9yYWwgdGhlcmFweSBmb3IgaW5zb21uaWEgb24gc2xlZXAgYW5k
IGRheXRpbWUgZnVuY3Rpb25pbmcgaW4gY29sbGVnZSBzdHVkZW50czwvdGl0bGU+PHNlY29uZGFy
eS10aXRsZT5CZWhhdiBUaGVyPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5CZWhhdmlvciB0
aGVyYXB5PC9hbHQtdGl0bGU+PC90aXRsZXM+PHBhZ2VzPjM3Ni04OTwvcGFnZXM+PHZvbHVtZT40
NTwvdm9sdW1lPjxudW1iZXI+MzwvbnVtYmVyPjxlZGl0aW9uPjIwMTQvMDQvMDE8L2VkaXRpb24+
PGtleXdvcmRzPjxrZXl3b3JkPkFjdGlncmFwaHkvbWV0aG9kczwva2V5d29yZD48a2V5d29yZD5B
ZG9sZXNjZW50PC9rZXl3b3JkPjxrZXl3b3JkPkFkdWx0PC9rZXl3b3JkPjxrZXl3b3JkPkNvZ25p
dGlvbi8qcGh5c2lvbG9neTwva2V5d29yZD48a2V5d29yZD5Db2duaXRpdmUgVGhlcmFweS8qbWV0
aG9kczwva2V5d29yZD48a2V5d29yZD5GZW1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+Rm9sbG93LVVw
IFN0dWRpZXM8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPk1hbGU8
L2tleXdvcmQ+PGtleXdvcmQ+U2xlZXAvKnBoeXNpb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+U2xl
ZXAgSW5pdGlhdGlvbiBhbmQgTWFpbnRlbmFuY2UgRGlzb3JkZXJzL2RpYWdub3Npcy9wc3ljaG9s
b2d5Lyp0aGVyYXB5PC9rZXl3b3JkPjxrZXl3b3JkPipTdHVkZW50czwva2V5d29yZD48a2V5d29y
ZD5TdXJ2ZXlzIGFuZCBRdWVzdGlvbm5haXJlczwva2V5d29yZD48a2V5d29yZD5UaW1lIEZhY3Rv
cnM8L2tleXdvcmQ+PGtleXdvcmQ+VHJlYXRtZW50IE91dGNvbWU8L2tleXdvcmQ+PGtleXdvcmQ+
WW91bmcgQWR1bHQ8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxNDwveWVhcj48
cHViLWRhdGVzPjxkYXRlPk1heTwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE4Nzgt
MTg4OCAoRWxlY3Ryb25pYykmI3hEOzAwMDUtNzg5NCAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lv
bi1udW0+MjQ2ODAyMzI8L2FjY2Vzc2lvbi1udW0+PHdvcmstdHlwZT5SYW5kb21pemVkIENvbnRy
b2xsZWQgVHJpYWwmI3hEO1Jlc2VhcmNoIFN1cHBvcnQsIE5vbi1VLlMuIEdvdiZhcG9zO3Q8L3dv
cmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWgu
Z292L3B1Ym1lZC8yNDY4MDIzMjwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25p
Yy1yZXNvdXJjZS1udW0+MTAuMTAxNi9qLmJldGguMjAxMy4xMi4wMTA8L2VsZWN0cm9uaWMtcmVz
b3VyY2UtbnVtPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48
QXV0aG9yPldpbGNrZW5zPC9BdXRob3I+PFllYXI+MjAxNjwvWWVhcj48UmVjTnVtPjI4ODwvUmVj
TnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+Mjg4PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtl
eSBhcHA9IkVOIiBkYi1pZD0iNXByd2U1c2Exc3oyc3BlZWZ3cjV0eDBveGR3OXN6enhwYXNyIj4y
ODg8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4x
NzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPldpbGNrZW5zLCBLLiBB
LjwvYXV0aG9yPjxhdXRob3I+SGFsbCwgTS4gSC48L2F1dGhvcj48YXV0aG9yPk5lYmVzLCBSLiBE
LjwvYXV0aG9yPjxhdXRob3I+TW9uaywgVC4gSC48L2F1dGhvcj48YXV0aG9yPkJ1eXNzZSwgRC4g
Si48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5hIERlcGFy
dG1lbnQgb2YgUHN5Y2hpYXRyeSAsIFVuaXZlcnNpdHkgb2YgUGl0dHNidXJnaCBTY2hvb2wgb2Yg
TWVkaWNpbmUgLCBVU0EuPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+Q2hhbmdlcyBpbiBD
b2duaXRpdmUgUGVyZm9ybWFuY2UgQXJlIEFzc29jaWF0ZWQgd2l0aCBDaGFuZ2VzIGluIFNsZWVw
IGluIE9sZGVyIEFkdWx0cyBXaXRoIEluc29tbmlhPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkJl
aGF2IFNsZWVwIE1lZDwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+QmVoYXZpb3JhbCBzbGVl
cCBtZWRpY2luZTwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkJl
aGF2IFNsZWVwIE1lZDwvZnVsbC10aXRsZT48YWJici0xPkJlaGF2aW9yYWwgc2xlZXAgbWVkaWNp
bmU8L2FiYnItMT48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkJlaGF2
IFNsZWVwIE1lZDwvZnVsbC10aXRsZT48YWJici0xPkJlaGF2aW9yYWwgc2xlZXAgbWVkaWNpbmU8
L2FiYnItMT48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz4yOTUtMzEwPC9wYWdlcz48dm9sdW1lPjE0
PC92b2x1bWU+PG51bWJlcj4zPC9udW1iZXI+PGVkaXRpb24+MjAxNS8wOS8wMTwvZWRpdGlvbj48
ZGF0ZXM+PHllYXI+MjAxNjwveWVhcj48cHViLWRhdGVzPjxkYXRlPk1heS1KdW48L2RhdGU+PC9w
dWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNTQwLTIwMTAgKEVsZWN0cm9uaWMpJiN4RDsxNTQwLTIw
MDIgKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjI2MzIyOTA0PC9hY2Nlc3Npb24tbnVt
Pjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVi
bWVkLzI2MzIyOTA0PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxjdXN0b20yPjQ3NzU0NjM8
L2N1c3RvbTI+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEwODAvMTU0MDIwMDIuMjAxNC4x
MDAyMDM0PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48
L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPgB=
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bcm5lZHQ8L0F1dGhvcj48WWVhcj4yMDExPC9ZZWFyPjxS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ADDIN EN.CITE.DATA (45-55), five uncontrolled trials PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bcm5lZHQ8L0F1dGhvcj48WWVhcj4yMDA3PC9ZZWFyPjxS
ZWNOdW0+MjUzPC9SZWNOdW0+PERpc3BsYXlUZXh0Pig1Ni02MCk8L0Rpc3BsYXlUZXh0PjxyZWNv
cmQ+PHJlYy1udW1iZXI+MjUzPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVO
IiBkYi1pZD0iNXByd2U1c2Exc3oyc3BlZWZ3cjV0eDBveGR3OXN6enhwYXNyIj4yNTM8L2tleT48
L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5
cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkFybmVkdCwgSi4gVC48L2F1dGhvcj48
YXV0aG9yPkNvbnJveSwgRC48L2F1dGhvcj48YXV0aG9yPlJ1dHQsIEouPC9hdXRob3I+PGF1dGhv
cj5BbG9pYSwgTS4gUy48L2F1dGhvcj48YXV0aG9yPkJyb3dlciwgSy4gSi48L2F1dGhvcj48YXV0
aG9yPkFybWl0YWdlLCBSLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1h
ZGRyZXNzPlVuaXZlcnNpdHkgb2YgTWljaGlnYW4gU2xlZXAgYW5kIENocm9ub3BoeXNpb2xvZ3kg
TGFib3JhdG9yeSwgQW5uIEFyYm9yLCBNSSwgVVNBLiB0YXJuZWR0QG1lZC51bWljaC5lZHU8L2F1
dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5BbiBvcGVuIHRyaWFsIG9mIGNvZ25pdGl2ZS1iZWhh
dmlvcmFsIHRyZWF0bWVudCBmb3IgaW5zb21uaWEgY29tb3JiaWQgd2l0aCBhbGNvaG9sIGRlcGVu
ZGVuY2U8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+U2xlZXAgTWVkPC9zZWNvbmRhcnktdGl0bGU+
PGFsdC10aXRsZT5TbGVlcCBtZWRpY2luZTwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2Fs
PjxmdWxsLXRpdGxlPlNsZWVwIE1lZDwvZnVsbC10aXRsZT48YWJici0xPlNsZWVwIG1lZGljaW5l
PC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5TbGVlcCBN
ZWQ8L2Z1bGwtdGl0bGU+PGFiYnItMT5TbGVlcCBtZWRpY2luZTwvYWJici0xPjwvYWx0LXBlcmlv
ZGljYWw+PHBhZ2VzPjE3Ni04MDwvcGFnZXM+PHZvbHVtZT44PC92b2x1bWU+PG51bWJlcj4yPC9u
dW1iZXI+PGVkaXRpb24+MjAwNy8wMS8yNDwvZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QWR1
bHQ8L2tleXdvcmQ+PGtleXdvcmQ+QWxjb2hvbGlzbS9wc3ljaG9sb2d5LypyZWhhYmlsaXRhdGlv
bjwva2V5d29yZD48a2V5d29yZD4qQ29nbml0aXZlIFRoZXJhcHk8L2tleXdvcmQ+PGtleXdvcmQ+
Q29tb3JiaWRpdHk8L2tleXdvcmQ+PGtleXdvcmQ+Q3VsdHVyZTwva2V5d29yZD48a2V5d29yZD5G
ZW1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPk1hbGU8L2tl
eXdvcmQ+PGtleXdvcmQ+TWlkZGxlIEFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+T3V0Y29tZSBBc3Nl
c3NtZW50IChIZWFsdGggQ2FyZSk8L2tleXdvcmQ+PGtleXdvcmQ+UGlsb3QgUHJvamVjdHM8L2tl
eXdvcmQ+PGtleXdvcmQ+U2xlZXAgSW5pdGlhdGlvbiBhbmQgTWFpbnRlbmFuY2UgRGlzb3JkZXJz
L3BzeWNob2xvZ3kvKnJlaGFiaWxpdGF0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPlRlbXBlcmFuY2U8
L2tleXdvcmQ+PGtleXdvcmQ+V2FrZWZ1bG5lc3M8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+
PHllYXI+MjAwNzwveWVhcj48cHViLWRhdGVzPjxkYXRlPk1hcjwvZGF0ZT48L3B1Yi1kYXRlcz48
L2RhdGVzPjxpc2JuPjEzODktOTQ1NyAoUHJpbnQpJiN4RDsxMzg5LTk0NTcgKExpbmtpbmcpPC9p
c2JuPjxhY2Nlc3Npb24tbnVtPjE3MjM5NjU4PC9hY2Nlc3Npb24tbnVtPjx3b3JrLXR5cGU+Q2Fz
ZSBSZXBvcnRzJiN4RDtSZXNlYXJjaCBTdXBwb3J0LCBOLkkuSC4sIEV4dHJhbXVyYWw8L3dvcmst
dHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292
L3B1Ym1lZC8xNzIzOTY1ODwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1y
ZXNvdXJjZS1udW0+MTAuMTAxNi9qLnNsZWVwLjIwMDYuMDYuMDA3PC9lbGVjdHJvbmljLXJlc291
cmNlLW51bT48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1
dGhvcj5EYXZpZHNvbjwvQXV0aG9yPjxZZWFyPjIwMDE8L1llYXI+PFJlY051bT4yNTg8L1JlY051
bT48cmVjb3JkPjxyZWMtbnVtYmVyPjI1ODwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkg
YXBwPSJFTiIgZGItaWQ9IjVwcndlNXNhMXN6MnNwZWVmd3I1dHgwb3hkdzlzenp4cGFzciI+MjU4
PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8
L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5EYXZpZHNvbiwgSi4gUi48
L2F1dGhvcj48YXV0aG9yPldhaXNiZXJnLCBKLiBMLjwvYXV0aG9yPjxhdXRob3I+QnJ1bmRhZ2Us
IE0uIEQuPC9hdXRob3I+PGF1dGhvcj5NYWNMZWFuLCBBLiBXLjwvYXV0aG9yPjwvYXV0aG9ycz48
L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkRlcGFydG1lbnQgb2YgUHN5Y2hvbG9neSwgUXVl
ZW4mYXBvcztzIFVuaXZlcnNpdHksIEtpbmdzdG9uLCBPbnRhcmlvLCBDYW5hZGEuIGRhdmlkc25q
QHBvc3QucXVlZW5zdS5jYTwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPk5vbnBoYXJtYWNv
bG9naWMgZ3JvdXAgdHJlYXRtZW50IG9mIGluc29tbmlhOiBhIHByZWxpbWluYXJ5IHN0dWR5IHdp
dGggY2FuY2VyIHN1cnZpdm9yczwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5Qc3ljaG9vbmNvbG9n
eTwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+UHN5Y2hvLW9uY29sb2d5PC9hbHQtdGl0bGU+
PC90aXRsZXM+PHBhZ2VzPjM4OS05NzwvcGFnZXM+PHZvbHVtZT4xMDwvdm9sdW1lPjxudW1iZXI+
NTwvbnVtYmVyPjxlZGl0aW9uPjIwMDEvMDkvMDY8L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3b3Jk
PkF0dGl0dWRlIHRvIEhlYWx0aDwva2V5d29yZD48a2V5d29yZD5Db2duaXRpdmUgVGhlcmFweS8q
bWV0aG9kczwva2V5d29yZD48a2V5d29yZD5GZW1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5z
PC9rZXl3b3JkPjxrZXl3b3JkPkxvbmdpdHVkaW5hbCBTdHVkaWVzPC9rZXl3b3JkPjxrZXl3b3Jk
Pk1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+TWlkZGxlIEFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+TmVv
cGxhc21zLypjb21wbGljYXRpb25zL3BzeWNob2xvZ3kvdGhlcmFweTwva2V5d29yZD48a2V5d29y
ZD5QYXRpZW50IEVkdWNhdGlvbiBhcyBUb3BpYy8qbWV0aG9kczwva2V5d29yZD48a2V5d29yZD5Q
cm9ncmFtIEV2YWx1YXRpb248L2tleXdvcmQ+PGtleXdvcmQ+KlJlbGF4YXRpb24gVGhlcmFweTwv
a2V5d29yZD48a2V5d29yZD5TZXZlcml0eSBvZiBJbGxuZXNzIEluZGV4PC9rZXl3b3JkPjxrZXl3
b3JkPlNsZWVwIEluaXRpYXRpb24gYW5kIE1haW50ZW5hbmNlIERpc29yZGVycy8qZXRpb2xvZ3kv
cHN5Y2hvbG9neS8qdGhlcmFweTwva2V5d29yZD48a2V5d29yZD4qU3Vydml2b3JzL3BzeWNob2xv
Z3k8L2tleXdvcmQ+PGtleXdvcmQ+VGltZSBGYWN0b3JzPC9rZXl3b3JkPjxrZXl3b3JkPlRyZWF0
bWVudCBPdXRjb21lPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMDE8L3llYXI+
PHB1Yi1kYXRlcz48ZGF0ZT5TZXAtT2N0PC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+
MTA1Ny05MjQ5IChQcmludCkmI3hEOzEwNTctOTI0OSAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lv
bi1udW0+MTE1MzY0MTc8L2FjY2Vzc2lvbi1udW0+PHdvcmstdHlwZT5DbGluaWNhbCBUcmlhbCYj
eEQ7Q29udHJvbGxlZCBDbGluaWNhbCBUcmlhbCYjeEQ7UmVzZWFyY2ggU3VwcG9ydCwgTm9uLVUu
Uy4gR292JmFwb3M7dDwvd29yay10eXBlPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8v
d3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzExNTM2NDE3PC91cmw+PC9yZWxhdGVkLXVybHM+
PC91cmxzPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0
aG9yPkxhbWk8L0F1dGhvcj48WWVhcj4yMDE2PC9ZZWFyPjxSZWNOdW0+MjY2PC9SZWNOdW0+PHJl
Y29yZD48cmVjLW51bWJlcj4yNjY8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0i
RU4iIGRiLWlkPSI1cHJ3ZTVzYTFzejJzcGVlZndyNXR4MG94ZHc5c3p6eHBhc3IiPjI2Njwva2V5
PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYt
dHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+TGFtaSwgTS4gSi48L2F1dGhvcj48
YXV0aG9yPk1hcnRpbmV6LCBNLiBQLjwvYXV0aG9yPjxhdXRob3I+U2FuY2hleiwgQS4gSS48L2F1
dGhvcj48YXV0aG9yPk1pcm8sIEUuPC9hdXRob3I+PGF1dGhvcj5EaWVuZXIsIEYuIE4uPC9hdXRo
b3I+PGF1dGhvcj5QcmFkb3MsIEcuPC9hdXRob3I+PGF1dGhvcj5HdXptYW4sIE0uIEEuPC9hdXRo
b3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+RGVwYXJ0bWVudCBvZiBQ
ZXJzb25hbGl0eSwgQXNzZXNzbWVudCwgYW5kIFBzeWNob2xvZ2ljYWwgVHJlYXRtZW50LCBGYWN1
bHR5IG9mIFBzeWNob2xvZ3ksIFVuaXZlcnNpdHkgb2YgR3JhbmFkYSwgR3JhbmFkYSwgU3BhaW4u
JiN4RDtNaW5kLCBCcmFpbiBhbmQgQmVoYXZpb3IgUmVzZWFyY2ggQ2VudGVyIChDSU1DWUMpLCBV
bml2ZXJzaXR5IG9mIEdyYW5hZGEsIEdyYW5hZGEsIFNwYWluLiYjeEQ7SW50ZXJuYWwgTWVkaWNp
bmUgU2VydmljZSwgVmlyZ2VuIGRlIGxhcyBOaWV2ZXMgVW5pdmVyc2l0eSBIb3NwaXRhbCwgYW5k
IFJoZXVtYXRvbG9neSBTZXJ2aWNlLCBWaXJnZW4gZGUgbGFzIE5pZXZlcyBVbml2ZXJzaXR5IEhv
c3BpdGFsLCBHcmFuYWRhLCBTcGFpbi48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5HZW5k
ZXIgRGlmZmVyZW5jZXMgaW4gUGF0aWVudHMgd2l0aCBGaWJyb215YWxnaWEgVW5kZXJnb2luZyBD
b2duaXRpdmUtQmVoYXZpb3JhbCBUaGVyYXB5IGZvciBJbnNvbW5pYTogUHJlbGltaW5hcnkgRGF0
YTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5QYWluIFByYWN0PC9zZWNvbmRhcnktdGl0bGU+PGFs
dC10aXRsZT5QYWluIHByYWN0aWNlIDogdGhlIG9mZmljaWFsIGpvdXJuYWwgb2YgV29ybGQgSW5z
dGl0dXRlIG9mIFBhaW48L2FsdC10aXRsZT48L3RpdGxlcz48cGFnZXM+RTIzLTM0PC9wYWdlcz48
dm9sdW1lPjE2PC92b2x1bWU+PG51bWJlcj4yPC9udW1iZXI+PGVkaXRpb24+MjAxNi8wMi8wNDwv
ZWRpdGlvbj48ZGF0ZXM+PHllYXI+MjAxNjwveWVhcj48cHViLWRhdGVzPjxkYXRlPkZlYjwvZGF0
ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE1MzMtMjUwMCAoRWxlY3Ryb25pYykmI3hEOzE1
MzAtNzA4NSAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MjY4NDExOTg8L2FjY2Vzc2lv
bi1udW0+PHdvcmstdHlwZT5SZXNlYXJjaCBTdXBwb3J0LCBOb24tVS5TLiBHb3YmYXBvczt0PC93
b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0ubmlo
Lmdvdi9wdWJtZWQvMjY4NDExOTg8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGVsZWN0cm9u
aWMtcmVzb3VyY2UtbnVtPjEwLjExMTEvcGFwci4xMjQxMTwvZWxlY3Ryb25pYy1yZXNvdXJjZS1u
dW0+PGxhbmd1YWdlPmVuZzwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+
U3dhbnNvbjwvQXV0aG9yPjxZZWFyPjIwMTM8L1llYXI+PFJlY051bT4yNDk8L1JlY051bT48cmVj
b3JkPjxyZWMtbnVtYmVyPjI0OTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJF
TiIgZGItaWQ9IjVwcndlNXNhMXN6MnNwZWVmd3I1dHgwb3hkdzlzenp4cGFzciI+MjQ5PC9rZXk+
PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10
eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5Td2Fuc29uLCBMLiBNLjwvYXV0aG9y
PjxhdXRob3I+Rmx5bm4sIEguPC9hdXRob3I+PGF1dGhvcj5BZGFtcy1NdW5keSwgSi4gRC48L2F1
dGhvcj48YXV0aG9yPkFybWl0YWdlLCBSLjwvYXV0aG9yPjxhdXRob3I+QXJuZWR0LCBKLiBULjwv
YXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkRlcGFydG1lbnQg
b2YgUHN5Y2hpYXRyeSwgVW5pdmVyc2l0eSBvZiBNaWNoaWdhbiwgVVNBLiBMTVN3YW5AbWVkLnVt
aWNoLmVkdTwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkFuIG9wZW4gcGlsb3Qgb2YgY29n
bml0aXZlLWJlaGF2aW9yYWwgdGhlcmFweSBmb3IgaW5zb21uaWEgaW4gd29tZW4gd2l0aCBwb3N0
cGFydHVtIGRlcHJlc3Npb248L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+QmVoYXYgU2xlZXAgTWVk
PC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5CZWhhdmlvcmFsIHNsZWVwIG1lZGljaW5lPC9h
bHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+QmVoYXYgU2xlZXAgTWVk
PC9mdWxsLXRpdGxlPjxhYmJyLTE+QmVoYXZpb3JhbCBzbGVlcCBtZWRpY2luZTwvYWJici0xPjwv
cGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+QmVoYXYgU2xlZXAgTWVkPC9m
dWxsLXRpdGxlPjxhYmJyLTE+QmVoYXZpb3JhbCBzbGVlcCBtZWRpY2luZTwvYWJici0xPjwvYWx0
LXBlcmlvZGljYWw+PHBhZ2VzPjI5Ny0zMDc8L3BhZ2VzPjx2b2x1bWU+MTE8L3ZvbHVtZT48bnVt
YmVyPjQ8L251bWJlcj48ZWRpdGlvbj4yMDEyLzEyLzEyPC9lZGl0aW9uPjxrZXl3b3Jkcz48a2V5
d29yZD5BZHVsdDwva2V5d29yZD48a2V5d29yZD4qQWZmZWN0PC9rZXl3b3JkPjxrZXl3b3JkPipD
b2duaXRpdmUgVGhlcmFweTwva2V5d29yZD48a2V5d29yZD5EZXByZXNzaW9uLCBQb3N0cGFydHVt
Lypjb21wbGljYXRpb25zPC9rZXl3b3JkPjxrZXl3b3JkPkZhdGlndWUvY29tcGxpY2F0aW9ucy9w
c3ljaG9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29yZD5IdW1h
bnM8L2tleXdvcmQ+PGtleXdvcmQ+UGlsb3QgUHJvamVjdHM8L2tleXdvcmQ+PGtleXdvcmQ+U2V2
ZXJpdHkgb2YgSWxsbmVzcyBJbmRleDwva2V5d29yZD48a2V5d29yZD4qU2xlZXA8L2tleXdvcmQ+
PGtleXdvcmQ+U2xlZXAgSW5pdGlhdGlvbiBhbmQgTWFpbnRlbmFuY2UgRGlzb3JkZXJzL2NvbXBs
aWNhdGlvbnMvcHN5Y2hvbG9neS8qdGhlcmFweTwva2V5d29yZD48a2V5d29yZD5UcmVhdG1lbnQg
T3V0Y29tZTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDEzPC95ZWFyPjwvZGF0
ZXM+PGlzYm4+MTU0MC0yMDEwIChFbGVjdHJvbmljKSYjeEQ7MTU0MC0yMDAyIChMaW5raW5nKTwv
aXNibj48YWNjZXNzaW9uLW51bT4yMzIxNjM3MzwvYWNjZXNzaW9uLW51bT48d29yay10eXBlPlJl
c2VhcmNoIFN1cHBvcnQsIE5vbi1VLlMuIEdvdiZhcG9zO3Q8L3dvcmstdHlwZT48dXJscz48cmVs
YXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8yMzIxNjM3
MzwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAu
MTA4MC8xNTQwMjAwMi4yMDEyLjY4MzkwMjwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PGxhbmd1
YWdlPmVuZzwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+VG9tZm9oci1N
YWRzZW48L0F1dGhvcj48WWVhcj4yMDE2PC9ZZWFyPjxSZWNOdW0+Mjg3PC9SZWNOdW0+PHJlY29y
ZD48cmVjLW51bWJlcj4yODc8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4i
IGRiLWlkPSI1cHJ3ZTVzYTFzejJzcGVlZndyNXR4MG94ZHc5c3p6eHBhc3IiPjI4Nzwva2V5Pjwv
Zm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlw
ZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+VG9tZm9oci1NYWRzZW4sIEwuIE0uPC9h
dXRob3I+PGF1dGhvcj5DbGF5Ym9ybmUsIFouIE0uPC9hdXRob3I+PGF1dGhvcj5Sb3VsZWF1LCBD
LiBSLjwvYXV0aG9yPjxhdXRob3I+Q2FtcGJlbGwsIFQuIFMuPC9hdXRob3I+PC9hdXRob3JzPjwv
Y29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+YSBEZXBhcnRtZW50IG9mIFBzeWNob2xvZ3kgLCBV
bml2ZXJzaXR5IG9mIENhbGdhcnkgLCBDYWxnYXJ5ICwgQWxiZXJ0YSAsIENhbmFkYS4mI3hEO2Ig
QWxiZXJ0YSBDaGlsZHJlbiZhcG9zO3MgSG9zcGl0YWwgUmVzZWFyY2ggSW5zdGl0dXRlIGZvciBD
aGlsZCBhbmQgTWF0ZXJuYWwgSGVhbHRoICwgQ2FsZ2FyeSAsIEFsYmVydGEgLCBDYW5hZGEuJiN4
RDtjIERlcGFydG1lbnQgb2YgUGVkaWF0cmljcyAsIEFsYmVydGEgQ2hpbGRyZW4mYXBvcztzIEhv
c3BpdGFsICwgQ2FsZ2FyeSAsIEFsYmVydGEgLCBDYW5hZGEuPC9hdXRoLWFkZHJlc3M+PHRpdGxl
cz48dGl0bGU+U2xlZXBpbmcgZm9yIFR3bzogQW4gT3Blbi1QaWxvdCBTdHVkeSBvZiBDb2duaXRp
dmUgQmVoYXZpb3JhbCBUaGVyYXB5IGZvciBJbnNvbW5pYSBpbiBQcmVnbmFuY3k8L3RpdGxlPjxz
ZWNvbmRhcnktdGl0bGU+QmVoYXYgU2xlZXAgTWVkPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRs
ZT5CZWhhdmlvcmFsIHNsZWVwIG1lZGljaW5lPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGlj
YWw+PGZ1bGwtdGl0bGU+QmVoYXYgU2xlZXAgTWVkPC9mdWxsLXRpdGxlPjxhYmJyLTE+QmVoYXZp
b3JhbCBzbGVlcCBtZWRpY2luZTwvYWJici0xPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+
PGZ1bGwtdGl0bGU+QmVoYXYgU2xlZXAgTWVkPC9mdWxsLXRpdGxlPjxhYmJyLTE+QmVoYXZpb3Jh
bCBzbGVlcCBtZWRpY2luZTwvYWJici0xPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjEtMTc8L3Bh
Z2VzPjxlZGl0aW9uPjIwMTYvMDQvMjk8L2VkaXRpb24+PGRhdGVzPjx5ZWFyPjIwMTY8L3llYXI+
PHB1Yi1kYXRlcz48ZGF0ZT5BcHIgMjg8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4x
NTQwLTIwMTAgKEVsZWN0cm9uaWMpJiN4RDsxNTQwLTIwMDIgKExpbmtpbmcpPC9pc2JuPjxhY2Nl
c3Npb24tbnVtPjI3MTI0NDA1PC9hY2Nlc3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVy
bD5odHRwOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzI3MTI0NDA1PC91cmw+PC9yZWxh
dGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMDgwLzE1NDAyMDAy
LjIwMTYuMTE0MTc2OTwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PGxhbmd1YWdlPkVuZzwvbGFu
Z3VhZ2U+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT5=
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bcm5lZHQ8L0F1dGhvcj48WWVhcj4yMDA3PC9ZZWFyPjxS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ADDIN EN.CITE.DATA (56-60), one non-randomised controlled trial ADDIN EN.CITE <EndNote><Cite><Author>Simeit</Author><Year>2004</Year><RecNum>279</RecNum><DisplayText>(61)</DisplayText><record><rec-number>279</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr">279</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Simeit, R.</author><author>Deck, R.</author><author>Conta-Marx, B.</author></authors></contributors><auth-address>Ropersbergklinik Ratzeburg, Ropersberg 47, 23909 Ratzeburg, Germany. info@rkrz.de</auth-address><titles><title>Sleep management training for cancer patients with insomnia</title><secondary-title>Support Care Cancer</secondary-title><alt-title>Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer</alt-title></titles><pages>176-83</pages><volume>12</volume><number>3</number><edition>2004/02/05</edition><keywords><keyword>Attitude to Health</keyword><keyword>Female</keyword><keyword>Health Care Surveys</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Neoplasms/*complications/psychology</keyword><keyword>Patient Education as Topic/*methods</keyword><keyword>Program Evaluation</keyword><keyword>Quality of Life</keyword><keyword>Relaxation Therapy/*education</keyword><keyword>Sleep Initiation and Maintenance Disorders/prevention & control/*rehabilitation</keyword><keyword>Surveys and Questionnaires</keyword></keywords><dates><year>2004</year><pub-dates><date>Mar</date></pub-dates></dates><isbn>0941-4355 (Print)
0941-4355 (Linking)</isbn><accession-num>14760542</accession-num><work-type>Clinical Trial
Controlled Clinical Trial
Research Support, Non-U.S. Gov't</work-type><urls><related-urls><url>;(61) and one case series ADDIN EN.CITE <EndNote><Cite><Author>Quesnel</Author><Year>2003</Year><RecNum>276</RecNum><DisplayText>(62)</DisplayText><record><rec-number>276</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr">276</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Quesnel, C.</author><author>Savard, J.</author><author>Simard, S.</author><author>Ivers, H.</author><author>Morin, C. M.</author></authors></contributors><auth-address>School of Psychology and Cancer Research Centre, Universite Laval, Quebec, Quebec, Canada.</auth-address><titles><title>Efficacy of cognitive-behavioral therapy for insomnia in women treated for nonmetastatic breast cancer</title><secondary-title>J Consult Clin Psychol</secondary-title><alt-title>Journal of consulting and clinical psychology</alt-title></titles><periodical><full-title>J Consult Clin Psychol</full-title></periodical><pages>189-200</pages><volume>71</volume><number>1</number><edition>2003/02/27</edition><keywords><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Breast Neoplasms/*psychology</keyword><keyword>Cognitive Therapy/*methods</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Middle Aged</keyword><keyword>Polysomnography</keyword><keyword>Quality of Life</keyword><keyword>Sleep Initiation and Maintenance Disorders/diagnosis/*etiology/*therapy</keyword><keyword>Surveys and Questionnaires</keyword></keywords><dates><year>2003</year><pub-dates><date>Feb</date></pub-dates></dates><isbn>0022-006X (Print)
0022-006X (Linking)</isbn><accession-num>12602439</accession-num><work-type>Clinical Trial
Research Support, Non-U.S. Gov't</work-type><urls><related-urls><url>;(62). Study characteristics are presented in table 1. Study qualityThe methodological quality of studies varied, with scores ranging between 10 and 20 out of a possible 26 (mean score = 15). The uncontrolled trials and the case series scored poorly due to the high risk of bias. There were only two studies that attempted to blind participants to the intervention. Few studies used intent-to-treat analysis to limit bias from attrition. In the studies that administered cognitive tests, there was no blinding of outcome assessment. When weighing up the evidence, more weight was given to data from RCTs and higher quality studies. Full quality ratings for each of the included studies are shown in table S1.ParticipantsThe sample size of the included studies ranged from seven to 229. There were a total of 923 individuals with insomnia symptoms in the eighteen included studies. Across the studies, the mean age of participants was 50.0 years and 71.0% of participants were female. This is comparable to findings from another meta-analysis of outcomes following CBT-I ADDIN EN.CITE <EndNote><Cite><Author>Trauer</Author><Year>2015</Year><RecNum>197</RecNum><DisplayText>(27)</DisplayText><record><rec-number>197</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr">197</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Trauer, J. M.</author><author>Qian, M. Y.</author><author>Doyle, J. S.</author><author>Rajaratnam, S. M.</author><author>Cunnington, D.</author></authors></contributors><titles><title>Cognitive Behavioral Therapy for Chronic Insomnia: A Systematic Review and Meta-analysis</title><secondary-title>Ann Intern Med</secondary-title><alt-title>Annals of internal medicine</alt-title></titles><pages>191-204</pages><volume>163</volume><number>3</number><edition>2015/06/09</edition><keywords><keyword>Chronic Disease</keyword><keyword>*Cognitive Therapy</keyword><keyword>Humans</keyword><keyword>Relaxation Therapy</keyword><keyword>Sleep Initiation and Maintenance Disorders/psychology/*therapy</keyword><keyword>Time Factors</keyword></keywords><dates><year>2015</year><pub-dates><date>Aug 4</date></pub-dates></dates><isbn>1539-3704 (Electronic)
0003-4819 (Linking)</isbn><accession-num>26054060</accession-num><work-type>Meta-Analysis
Review</work-type><urls><related-urls><url>;(27) and is consistent with research showing that insomnia symptoms are more common in women and with advancing age PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TaXZlcnRzZW48L0F1dGhvcj48WWVhcj4yMDA5PC9ZZWFy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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TaXZlcnRzZW48L0F1dGhvcj48WWVhcj4yMDA5PC9ZZWFy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ADDIN EN.CITE.DATA (63). The criteria used to verify insomnia varied across studies. Half of the studies used the DSM-IV ADDIN EN.CITE <EndNote><Cite><Year>1994</Year><RecNum>385</RecNum><DisplayText>(64)</DisplayText><record><rec-number>385</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr">385</key></foreign-keys><ref-type name="Book">6</ref-type><contributors></contributors><titles><title>Diagnostic and statistical manual of mental disorders : DSM-IV</title></titles><edition>4th ed.</edition><keywords><keyword>Mental illness Classification.</keyword><keyword>Mental illness Diagnosis.</keyword></keywords><dates><year>1994</year></dates><pub-location>Washington, D.C.</pub-location><publisher>American Psychiatric Association</publisher><isbn>0890420629 (pbk)
0890420610 (cased)</isbn><accession-num>adv010031788x</accession-num><call-num>616.89/075 20
British Library DSC q94/15280
British Library HMNTS YK.1996.b.9493</call-num><urls></urls></record></Cite></EndNote>(64), DSM-V ADDIN EN.CITE <EndNote><Cite><RecNum>3</RecNum><DisplayText>(7)</DisplayText><record><rec-number>3</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr">3</key></foreign-keys><ref-type name="Book">6</ref-type><contributors><authors><author>American Psychiatric Association</author></authors></contributors><titles><title>Diagnostic and statistical manual of mental disorders : DSM-5</title><alt-title>Dsm-5</alt-title></titles><edition>Fifth edition.</edition><keywords><keyword>Mental illness Diagnosis Handbooks, manuals, etc.</keyword><keyword>Mental illness Statistics.</keyword><keyword>Mental Disorders classification.</keyword><keyword>Mental Disorders diagnosis.</keyword><keyword>Diagnostic and statistical manual of mental disorders. 5th ed.</keyword></keywords><dates><year>2013</year></dates><pub-location>Arlington, VA</pub-location><publisher>American Psychiatric Publishing</publisher><isbn>9780890425541 (Hardcover)
9780890425558 (Paperback)</isbn><accession-num>(DNLM)101604226</accession-num><call-num>616.89075 23
British Library DSC m13/.15124
British Library STI (B) 616.89075
British Library STI (B) 616.89075 Enquiry Desk Science 2</call-num><urls></urls></record></Cite></EndNote>(7) or research diagnostic criteria ADDIN EN.CITE <EndNote><Cite><Author>Edinger</Author><Year>2004</Year><RecNum>134</RecNum><DisplayText>(2)</DisplayText><record><rec-number>134</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr">134</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Edinger, J. D.</author><author>Bonnet, M. H.</author><author>Bootzin, R. R.</author><author>Doghramji, K.</author><author>Dorsey, C. M.</author><author>Espie, C. A.</author><author>Jamieson, A. O.</author><author>McCall, W. V.</author><author>Morin, C. M.</author><author>Stepanski, E. J.</author></authors></contributors><auth-address>VA Medical Center, Durham, NC, USA.</auth-address><titles><title>Derivation of research diagnostic criteria for insomnia: report of an American Academy of Sleep Medicine Work Group</title><secondary-title>Sleep</secondary-title><alt-title>Sleep</alt-title></titles><periodical><full-title>Sleep</full-title><abbr-1>Sleep</abbr-1></periodical><alt-periodical><full-title>Sleep</full-title><abbr-1>Sleep</abbr-1></alt-periodical><pages>1567-96</pages><volume>27</volume><number>8</number><edition>2005/02/03</edition><keywords><keyword>Diagnostic and Statistical Manual of Mental Disorders</keyword><keyword>Humans</keyword><keyword>Reference Values</keyword><keyword>Reproducibility of Results</keyword><keyword>Sleep Initiation and Maintenance Disorders/classification/*diagnosis</keyword></keywords><dates><year>2004</year><pub-dates><date>Dec 15</date></pub-dates></dates><isbn>0161-8105 (Print)
0161-8105 (Linking)</isbn><accession-num>15683149</accession-num><work-type>Consensus Development Conference
Research Support, Non-U.S. Gov't
Review</work-type><urls><related-urls><url>;(2) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bcm5lZHQ8L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFyPjxS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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bcm5lZHQ8L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFyPjxS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ADDIN EN.CITE.DATA (46, 50-52, 54, 55, 58, 61, 62). Six studies used scores on the ISI combined with self-report difficulties with sleep onset/maintenance PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bcm5lZHQ8L0F1dGhvcj48WWVhcj4yMDA3PC9ZZWFyPjxS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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bcm5lZHQ8L0F1dGhvcj48WWVhcj4yMDA3PC9ZZWFyPjxS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ADDIN EN.CITE.DATA (45, 47, 49, 56, 59, 60). One study used scores on the PSQI ADDIN EN.CITE <EndNote><Cite><Author>Sun</Author><Year>2013</Year><RecNum>280</RecNum><DisplayText>(53)</DisplayText><record><rec-number>280</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr">280</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Sun, J.</author><author>Kang, J.</author><author>Wang, P.</author><author>Zeng, H.</author></authors></contributors><auth-address>School of Nursing, Central South University, Changsha, Hunan Province, China.</auth-address><titles><title>Self-relaxation training can improve sleep quality and cognitive functions in the older: a one-year randomised controlled trial</title><secondary-title>J Clin Nurs</secondary-title><alt-title>Journal of clinical nursing</alt-title></titles><pages>1270-80</pages><volume>22</volume><number>9-10</number><edition>2013/04/12</edition><keywords><keyword>Adolescent</keyword><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Aged, 80 and over</keyword><keyword>Analysis of Variance</keyword><keyword>Child</keyword><keyword>*Cognition</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Patient Education as Topic/*methods</keyword><keyword>*Relaxation Therapy</keyword><keyword>*Self Care</keyword><keyword>*Sleep</keyword><keyword>Surveys and Questionnaires</keyword><keyword>Young Adult</keyword></keywords><dates><year>2013</year><pub-dates><date>May</date></pub-dates></dates><isbn>1365-2702 (Electronic)
0962-1067 (Linking)</isbn><accession-num>23574290</accession-num><work-type>Randomized Controlled Trial
Research Support, Non-U.S. Gov't</work-type><urls><related-urls><url>;(53). Two studies developed their own criteria based on DSM-IV PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5EYXZpZHNvbjwvQXV0aG9yPjxZZWFyPjIwMDE8L1llYXI+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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5EYXZpZHNvbjwvQXV0aG9yPjxZZWFyPjIwMDE8L1llYXI+
PFJlY051bT4yNTg8L1JlY051bT48RGlzcGxheVRleHQ+KDQ4LCA1Nyk8L0Rpc3BsYXlUZXh0Pjxy
ZWNvcmQ+PHJlYy1udW1iZXI+MjU4PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9
IkVOIiBkYi1pZD0iNXByd2U1c2Exc3oyc3BlZWZ3cjV0eDBveGR3OXN6enhwYXNyIj4yNTg8L2tl
eT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVm
LXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkRhdmlkc29uLCBKLiBSLjwvYXV0
aG9yPjxhdXRob3I+V2Fpc2JlcmcsIEouIEwuPC9hdXRob3I+PGF1dGhvcj5CcnVuZGFnZSwgTS4g
RC48L2F1dGhvcj48YXV0aG9yPk1hY0xlYW4sIEEuIFcuPC9hdXRob3I+PC9hdXRob3JzPjwvY29u
dHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+RGVwYXJ0bWVudCBvZiBQc3ljaG9sb2d5LCBRdWVlbiZh
cG9zO3MgVW5pdmVyc2l0eSwgS2luZ3N0b24sIE9udGFyaW8sIENhbmFkYS4gZGF2aWRzbmpAcG9z
dC5xdWVlbnN1LmNhPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+Tm9ucGhhcm1hY29sb2dp
YyBncm91cCB0cmVhdG1lbnQgb2YgaW5zb21uaWE6IGEgcHJlbGltaW5hcnkgc3R1ZHkgd2l0aCBj
YW5jZXIgc3Vydml2b3JzPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPlBzeWNob29uY29sb2d5PC9z
ZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5Qc3ljaG8tb25jb2xvZ3k8L2FsdC10aXRsZT48L3Rp
dGxlcz48cGFnZXM+Mzg5LTk3PC9wYWdlcz48dm9sdW1lPjEwPC92b2x1bWU+PG51bWJlcj41PC9u
dW1iZXI+PGVkaXRpb24+MjAwMS8wOS8wNjwvZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QXR0
aXR1ZGUgdG8gSGVhbHRoPC9rZXl3b3JkPjxrZXl3b3JkPkNvZ25pdGl2ZSBUaGVyYXB5LyptZXRo
b2RzPC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tl
eXdvcmQ+PGtleXdvcmQ+TG9uZ2l0dWRpbmFsIFN0dWRpZXM8L2tleXdvcmQ+PGtleXdvcmQ+TWFs
ZTwva2V5d29yZD48a2V5d29yZD5NaWRkbGUgQWdlZDwva2V5d29yZD48a2V5d29yZD5OZW9wbGFz
bXMvKmNvbXBsaWNhdGlvbnMvcHN5Y2hvbG9neS90aGVyYXB5PC9rZXl3b3JkPjxrZXl3b3JkPlBh
dGllbnQgRWR1Y2F0aW9uIGFzIFRvcGljLyptZXRob2RzPC9rZXl3b3JkPjxrZXl3b3JkPlByb2dy
YW0gRXZhbHVhdGlvbjwva2V5d29yZD48a2V5d29yZD4qUmVsYXhhdGlvbiBUaGVyYXB5PC9rZXl3
b3JkPjxrZXl3b3JkPlNldmVyaXR5IG9mIElsbG5lc3MgSW5kZXg8L2tleXdvcmQ+PGtleXdvcmQ+
U2xlZXAgSW5pdGlhdGlvbiBhbmQgTWFpbnRlbmFuY2UgRGlzb3JkZXJzLypldGlvbG9neS9wc3lj
aG9sb2d5Lyp0aGVyYXB5PC9rZXl3b3JkPjxrZXl3b3JkPipTdXJ2aXZvcnMvcHN5Y2hvbG9neTwv
a2V5d29yZD48a2V5d29yZD5UaW1lIEZhY3RvcnM8L2tleXdvcmQ+PGtleXdvcmQ+VHJlYXRtZW50
IE91dGNvbWU8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAwMTwveWVhcj48cHVi
LWRhdGVzPjxkYXRlPlNlcC1PY3Q8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xMDU3
LTkyNDkgKFByaW50KSYjeEQ7MTA1Ny05MjQ5IChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51
bT4xMTUzNjQxNzwvYWNjZXNzaW9uLW51bT48d29yay10eXBlPkNsaW5pY2FsIFRyaWFsJiN4RDtD
b250cm9sbGVkIENsaW5pY2FsIFRyaWFsJiN4RDtSZXNlYXJjaCBTdXBwb3J0LCBOb24tVS5TLiBH
b3YmYXBvczt0PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cu
bmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMTE1MzY0MTc8L3VybD48L3JlbGF0ZWQtdXJscz48L3Vy
bHM+PGxhbmd1YWdlPmVuZzwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+
SmFuc3NvbjwvQXV0aG9yPjxZZWFyPjIwMDU8L1llYXI+PFJlY051bT4yNjM8L1JlY051bT48cmVj
b3JkPjxyZWMtbnVtYmVyPjI2MzwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJF
TiIgZGItaWQ9IjVwcndlNXNhMXN6MnNwZWVmd3I1dHgwb3hkdzlzenp4cGFzciI+MjYzPC9rZXk+
PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10
eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5KYW5zc29uLCBNLjwvYXV0aG9yPjxh
dXRob3I+TGludG9uLCBTLiBKLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0
aC1hZGRyZXNzPkRlcGFydG1lbnQgb2YgT2NjdXBhdGlvbmFsIGFuZCBFbnZpcm9ubWVudGFsIE1l
ZGljaW5lLCBPcmVicm8gTWVkaWNhbCBDZW50ZXIsIFMtNzAxIDg1IE9yZWJybywgU3dlZGVuLjwv
YXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkNvZ25pdGl2ZS1iZWhhdmlvcmFsIGdyb3VwIHRo
ZXJhcHkgYXMgYW4gZWFybHkgaW50ZXJ2ZW50aW9uIGZvciBpbnNvbW5pYTogYSByYW5kb21pemVk
IGNvbnRyb2xsZWQgdHJpYWw8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+SiBPY2N1cCBSZWhhYmls
PC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5Kb3VybmFsIG9mIG9jY3VwYXRpb25hbCByZWhh
YmlsaXRhdGlvbjwvYWx0LXRpdGxlPjwvdGl0bGVzPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRs
ZT5Kb3VybmFsIG9mIE9jY3VwYXRpb25hbCBSZWhhYmlsaXRhdGlvbjwvZnVsbC10aXRsZT48L2Fs
dC1wZXJpb2RpY2FsPjxwYWdlcz4xNzctOTA8L3BhZ2VzPjx2b2x1bWU+MTU8L3ZvbHVtZT48bnVt
YmVyPjI8L251bWJlcj48ZWRpdGlvbj4yMDA1LzA0LzIzPC9lZGl0aW9uPjxrZXl3b3Jkcz48a2V5
d29yZD5BZG9sZXNjZW50PC9rZXl3b3JkPjxrZXl3b3JkPkFkdWx0PC9rZXl3b3JkPjxrZXl3b3Jk
PkFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+QW54aWV0eTwva2V5d29yZD48a2V5d29yZD5BdHRpdHVk
ZSB0byBIZWFsdGg8L2tleXdvcmQ+PGtleXdvcmQ+KkNvZ25pdGl2ZSBUaGVyYXB5PC9rZXl3b3Jk
PjxrZXl3b3JkPkRlcHJlc3Npb248L2tleXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxr
ZXl3b3JkPkZvbGxvdy1VcCBTdHVkaWVzPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29y
ZD48a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3b3JkPk1pZGRsZSBBZ2VkPC9rZXl3b3JkPjxr
ZXl3b3JkPipQYXRpZW50IEVkdWNhdGlvbiBhcyBUb3BpYzwva2V5d29yZD48a2V5d29yZD4qUHN5
Y2hvdGhlcmFweSwgR3JvdXA8L2tleXdvcmQ+PGtleXdvcmQ+U2xlZXAgSW5pdGlhdGlvbiBhbmQg
TWFpbnRlbmFuY2UgRGlzb3JkZXJzL3BoeXNpb3BhdGhvbG9neS8qdGhlcmFweTwva2V5d29yZD48
a2V5d29yZD5TdXJ2ZXlzIGFuZCBRdWVzdGlvbm5haXJlczwva2V5d29yZD48a2V5d29yZD5UZWFj
aGluZyBNYXRlcmlhbHMvc3VwcGx5ICZhbXA7IGRpc3RyaWJ1dGlvbjwva2V5d29yZD48a2V5d29y
ZD5UaW1lIEZhY3RvcnM8L2tleXdvcmQ+PGtleXdvcmQ+VHJlYXRtZW50IE91dGNvbWU8L2tleXdv
cmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAwNTwveWVhcj48cHViLWRhdGVzPjxkYXRlPkp1
bjwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjEwNTMtMDQ4NyAoUHJpbnQpJiN4RDsx
MDUzLTA0ODcgKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjE1ODQ0Njc1PC9hY2Nlc3Np
b24tbnVtPjx3b3JrLXR5cGU+Q2xpbmljYWwgVHJpYWwmI3hEO1JhbmRvbWl6ZWQgQ29udHJvbGxl
ZCBUcmlhbCYjeEQ7UmVzZWFyY2ggU3VwcG9ydCwgTm9uLVUuUy4gR292JmFwb3M7dDwvd29yay10
eXBlPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5paC5nb3Yv
cHVibWVkLzE1ODQ0Njc1PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxsYW5ndWFnZT5lbmc8
L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+
ADDIN EN.CITE.DATA (48, 57).The included studies sampled individuals from a range of populations. There were two studies of individuals with fibromyalgia PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MYW1pPC9BdXRob3I+PFllYXI+MjAxNjwvWWVhcj48UmVj
TnVtPjI2NjwvUmVjTnVtPjxEaXNwbGF5VGV4dD4oNTAsIDU4KTwvRGlzcGxheVRleHQ+PHJlY29y
ZD48cmVjLW51bWJlcj4yNjY8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4i
IGRiLWlkPSI1cHJ3ZTVzYTFzejJzcGVlZndyNXR4MG94ZHc5c3p6eHBhc3IiPjI2Njwva2V5Pjwv
Zm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlw
ZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+TGFtaSwgTS4gSi48L2F1dGhvcj48YXV0
aG9yPk1hcnRpbmV6LCBNLiBQLjwvYXV0aG9yPjxhdXRob3I+U2FuY2hleiwgQS4gSS48L2F1dGhv
cj48YXV0aG9yPk1pcm8sIEUuPC9hdXRob3I+PGF1dGhvcj5EaWVuZXIsIEYuIE4uPC9hdXRob3I+
PGF1dGhvcj5QcmFkb3MsIEcuPC9hdXRob3I+PGF1dGhvcj5HdXptYW4sIE0uIEEuPC9hdXRob3I+
PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+RGVwYXJ0bWVudCBvZiBQZXJz
b25hbGl0eSwgQXNzZXNzbWVudCwgYW5kIFBzeWNob2xvZ2ljYWwgVHJlYXRtZW50LCBGYWN1bHR5
IG9mIFBzeWNob2xvZ3ksIFVuaXZlcnNpdHkgb2YgR3JhbmFkYSwgR3JhbmFkYSwgU3BhaW4uJiN4
RDtNaW5kLCBCcmFpbiBhbmQgQmVoYXZpb3IgUmVzZWFyY2ggQ2VudGVyIChDSU1DWUMpLCBVbml2
ZXJzaXR5IG9mIEdyYW5hZGEsIEdyYW5hZGEsIFNwYWluLiYjeEQ7SW50ZXJuYWwgTWVkaWNpbmUg
U2VydmljZSwgVmlyZ2VuIGRlIGxhcyBOaWV2ZXMgVW5pdmVyc2l0eSBIb3NwaXRhbCwgYW5kIFJo
ZXVtYXRvbG9neSBTZXJ2aWNlLCBWaXJnZW4gZGUgbGFzIE5pZXZlcyBVbml2ZXJzaXR5IEhvc3Bp
dGFsLCBHcmFuYWRhLCBTcGFpbi48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5HZW5kZXIg
RGlmZmVyZW5jZXMgaW4gUGF0aWVudHMgd2l0aCBGaWJyb215YWxnaWEgVW5kZXJnb2luZyBDb2du
aXRpdmUtQmVoYXZpb3JhbCBUaGVyYXB5IGZvciBJbnNvbW5pYTogUHJlbGltaW5hcnkgRGF0YTwv
dGl0bGU+PHNlY29uZGFyeS10aXRsZT5QYWluIFByYWN0PC9zZWNvbmRhcnktdGl0bGU+PGFsdC10
aXRsZT5QYWluIHByYWN0aWNlIDogdGhlIG9mZmljaWFsIGpvdXJuYWwgb2YgV29ybGQgSW5zdGl0
dXRlIG9mIFBhaW48L2FsdC10aXRsZT48L3RpdGxlcz48cGFnZXM+RTIzLTM0PC9wYWdlcz48dm9s
dW1lPjE2PC92b2x1bWU+PG51bWJlcj4yPC9udW1iZXI+PGVkaXRpb24+MjAxNi8wMi8wNDwvZWRp
dGlvbj48ZGF0ZXM+PHllYXI+MjAxNjwveWVhcj48cHViLWRhdGVzPjxkYXRlPkZlYjwvZGF0ZT48
L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE1MzMtMjUwMCAoRWxlY3Ryb25pYykmI3hEOzE1MzAt
NzA4NSAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MjY4NDExOTg8L2FjY2Vzc2lvbi1u
dW0+PHdvcmstdHlwZT5SZXNlYXJjaCBTdXBwb3J0LCBOb24tVS5TLiBHb3YmYXBvczt0PC93b3Jr
LXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdv
di9wdWJtZWQvMjY4NDExOTg8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGVsZWN0cm9uaWMt
cmVzb3VyY2UtbnVtPjEwLjExMTEvcGFwci4xMjQxMTwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+
PGxhbmd1YWdlPmVuZzwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+TWly
bzwvQXV0aG9yPjxZZWFyPjIwMTE8L1llYXI+PFJlY051bT4yNzE8L1JlY051bT48cmVjb3JkPjxy
ZWMtbnVtYmVyPjI3MTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGIt
aWQ9IjVwcndlNXNhMXN6MnNwZWVmd3I1dHgwb3hkdzlzenp4cGFzciI+MjcxPC9rZXk+PC9mb3Jl
aWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxj
b250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5NaXJvLCBFLjwvYXV0aG9yPjxhdXRob3I+THVw
aWFuZXosIEouPC9hdXRob3I+PGF1dGhvcj5NYXJ0aW5leiwgTS4gUC48L2F1dGhvcj48YXV0aG9y
PlNhbmNoZXosIEEuIEkuPC9hdXRob3I+PGF1dGhvcj5EaWF6LVBpZWRyYSwgQy48L2F1dGhvcj48
YXV0aG9yPkd1em1hbiwgTS4gQS48L2F1dGhvcj48YXV0aG9yPkJ1ZWxhLUNhc2FsLCBHLjwvYXV0
aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPlVuaXZlcnNpZGFkIGRl
IEdyYW5hZGEsIENhbXB1cyBVbml2ZXJzaXRhcmlvIGRlIGxhIENhcnR1amEsIHMvbiwgQ1AuIDE4
MDcxLCBHcmFuYWRhLCBTcGFpbi4gZW1pcm9AdWdyLmU8L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0
aXRsZT5Db2duaXRpdmUtYmVoYXZpb3JhbCB0aGVyYXB5IGZvciBpbnNvbW5pYSBpbXByb3ZlcyBh
dHRlbnRpb25hbCBmdW5jdGlvbiBpbiBmaWJyb215YWxnaWEgc3luZHJvbWU6IGEgcGlsb3QsIHJh
bmRvbWl6ZWQgY29udHJvbGxlZCB0cmlhbDwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5KIEhlYWx0
aCBQc3ljaG9sPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5Kb3VybmFsIG9mIGhlYWx0aCBw
c3ljaG9sb2d5PC9hbHQtdGl0bGU+PC90aXRsZXM+PHBhZ2VzPjc3MC04MjwvcGFnZXM+PHZvbHVt
ZT4xNjwvdm9sdW1lPjxudW1iZXI+NTwvbnVtYmVyPjxlZGl0aW9uPjIwMTEvMDIvMjU8L2VkaXRp
b24+PGtleXdvcmRzPjxrZXl3b3JkPkFjdGl2aXRpZXMgb2YgRGFpbHkgTGl2aW5nL3BzeWNob2xv
Z3k8L2tleXdvcmQ+PGtleXdvcmQ+QWR1bHQ8L2tleXdvcmQ+PGtleXdvcmQ+QXR0ZW50aW9uPC9r
ZXl3b3JkPjxrZXl3b3JkPipDb2duaXRpdmUgVGhlcmFweS9tZXRob2RzPC9rZXl3b3JkPjxrZXl3
b3JkPkV4ZWN1dGl2ZSBGdW5jdGlvbjwva2V5d29yZD48a2V5d29yZD5GZW1hbGU8L2tleXdvcmQ+
PGtleXdvcmQ+Rmlicm9teWFsZ2lhL2NvbXBsaWNhdGlvbnMvcHN5Y2hvbG9neS8qdGhlcmFweTwv
a2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+TWlkZGxlIEFnZWQ8L2tl
eXdvcmQ+PGtleXdvcmQ+TmV1cm9wc3ljaG9sb2dpY2FsIFRlc3RzPC9rZXl3b3JkPjxrZXl3b3Jk
PlBpbG90IFByb2plY3RzPC9rZXl3b3JkPjxrZXl3b3JkPlNsZWVwPC9rZXl3b3JkPjxrZXl3b3Jk
PlNsZWVwIEluaXRpYXRpb24gYW5kIE1haW50ZW5hbmNlIERpc29yZGVycy9jb21wbGljYXRpb25z
L3BzeWNob2xvZ3kvKnRoZXJhcHk8L2tleXdvcmQ+PGtleXdvcmQ+U3VydmV5cyBhbmQgUXVlc3Rp
b25uYWlyZXM8L2tleXdvcmQ+PGtleXdvcmQ+VHJlYXRtZW50IE91dGNvbWU8L2tleXdvcmQ+PC9r
ZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxMTwveWVhcj48cHViLWRhdGVzPjxkYXRlPkp1bDwvZGF0
ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE0NjEtNzI3NyAoRWxlY3Ryb25pYykmI3hEOzEz
NTktMTA1MyAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MjEzNDYwMjA8L2FjY2Vzc2lv
bi1udW0+PHdvcmstdHlwZT5SYW5kb21pemVkIENvbnRyb2xsZWQgVHJpYWwmI3hEO1Jlc2VhcmNo
IFN1cHBvcnQsIE5vbi1VLlMuIEdvdiZhcG9zO3Q8L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11
cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8yMTM0NjAyMDwvdXJs
PjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTE3Ny8x
MzU5MTA1MzEwMzkwNTQ0PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48bGFuZ3VhZ2U+ZW5nPC9s
YW5ndWFnZT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPgB=
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MYW1pPC9BdXRob3I+PFllYXI+MjAxNjwvWWVhcj48UmVj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ADDIN EN.CITE.DATA (50, 58), six studies of cancer patients PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DYXNhdWx0PC9BdXRob3I+PFllYXI+MjAxNTwvWWVhcj48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==
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DYXNhdWx0PC9BdXRob3I+PFllYXI+MjAxNTwvWWVhcj48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==
ADDIN EN.CITE.DATA (47, 49, 52, 57, 61, 62), two studies of adults recovering from alcohol dependence PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bcm5lZHQ8L0F1dGhvcj48WWVhcj4yMDA3PC9ZZWFyPjxS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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bcm5lZHQ8L0F1dGhvcj48WWVhcj4yMDA3PC9ZZWFyPjxS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ADDIN EN.CITE.DATA (45, 56), one study of college students PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5UYXlsb3I8L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxS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=
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5UYXlsb3I8L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxS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=
ADDIN EN.CITE.DATA (54), three studies of older adults PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5PbXZpazwvQXV0aG9yPjxZZWFyPjIwMDg8L1llYXI+PFJl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==
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5PbXZpazwvQXV0aG9yPjxZZWFyPjIwMDg8L1llYXI+PFJl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==
ADDIN EN.CITE.DATA (51, 53, 55), one study of women with post-partum depression ADDIN EN.CITE <EndNote><Cite><Author>Swanson</Author><Year>2013</Year><RecNum>249</RecNum><DisplayText>(59)</DisplayText><record><rec-number>249</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr">249</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Swanson, L. M.</author><author>Flynn, H.</author><author>Adams-Mundy, J. D.</author><author>Armitage, R.</author><author>Arnedt, J. T.</author></authors></contributors><auth-address>Department of Psychiatry, University of Michigan, USA. LMSwan@med.umich.edu</auth-address><titles><title>An open pilot of cognitive-behavioral therapy for insomnia in women with postpartum depression</title><secondary-title>Behav Sleep Med</secondary-title><alt-title>Behavioral sleep medicine</alt-title></titles><periodical><full-title>Behav Sleep Med</full-title><abbr-1>Behavioral sleep medicine</abbr-1></periodical><alt-periodical><full-title>Behav Sleep Med</full-title><abbr-1>Behavioral sleep medicine</abbr-1></alt-periodical><pages>297-307</pages><volume>11</volume><number>4</number><edition>2012/12/12</edition><keywords><keyword>Adult</keyword><keyword>*Affect</keyword><keyword>*Cognitive Therapy</keyword><keyword>Depression, Postpartum/*complications</keyword><keyword>Fatigue/complications/psychology</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Pilot Projects</keyword><keyword>Severity of Illness Index</keyword><keyword>*Sleep</keyword><keyword>Sleep Initiation and Maintenance Disorders/complications/psychology/*therapy</keyword><keyword>Treatment Outcome</keyword></keywords><dates><year>2013</year></dates><isbn>1540-2010 (Electronic)
1540-2002 (Linking)</isbn><accession-num>23216373</accession-num><work-type>Research Support, Non-U.S. Gov't</work-type><urls><related-urls><url>;(59), one study of pregnant women ADDIN EN.CITE <EndNote><Cite><Author>Tomfohr-Madsen</Author><Year>2016</Year><RecNum>287</RecNum><DisplayText>(60)</DisplayText><record><rec-number>287</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr">287</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Tomfohr-Madsen, L. M.</author><author>Clayborne, Z. M.</author><author>Rouleau, C. R.</author><author>Campbell, T. S.</author></authors></contributors><auth-address>a Department of Psychology , University of Calgary , Calgary , Alberta , Canada.
b Alberta Children's Hospital Research Institute for Child and Maternal Health , Calgary , Alberta , Canada.
c Department of Pediatrics , Alberta Children's Hospital , Calgary , Alberta , Canada.</auth-address><titles><title>Sleeping for Two: An Open-Pilot Study of Cognitive Behavioral Therapy for Insomnia in Pregnancy</title><secondary-title>Behav Sleep Med</secondary-title><alt-title>Behavioral sleep medicine</alt-title></titles><periodical><full-title>Behav Sleep Med</full-title><abbr-1>Behavioral sleep medicine</abbr-1></periodical><alt-periodical><full-title>Behav Sleep Med</full-title><abbr-1>Behavioral sleep medicine</abbr-1></alt-periodical><pages>1-17</pages><edition>2016/04/29</edition><dates><year>2016</year><pub-dates><date>Apr 28</date></pub-dates></dates><isbn>1540-2010 (Electronic)
1540-2002 (Linking)</isbn><accession-num>27124405</accession-num><urls><related-urls><url>;(60) and two studies of adults without any psychiatric or physical health comorbidities PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bcm5lZHQ8L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFyPjxS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=
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bcm5lZHQ8L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFyPjxS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=
ADDIN EN.CITE.DATA (46, 48). In the majority of included studies (13/18), insomnia was considered “secondary” to, or comorbid with, a physical or mental health condition PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bcm5lZHQ8L0F1dGhvcj48WWVhcj4yMDA3PC9ZZWFyPjxS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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bcm5lZHQ8L0F1dGhvcj48WWVhcj4yMDA3PC9ZZWFyPjxS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ADDIN EN.CITE.DATA (45, 47, 49, 50, 52, 55-62). Of those studies which reported the duration of insomnia symptoms (10/18), mean values for the sample ranged from 3.9-174 months, with an average duration across studies of 75.83 months.InterventionsThe majority of studies (16/18) delivered an intervention which combined cognitive, behavioural and educational components. There were two exceptions; Wilckens et al. ADDIN EN.CITE <EndNote><Cite><Author>Wilckens</Author><Year>2016</Year><RecNum>288</RecNum><DisplayText>(55)</DisplayText><record><rec-number>288</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr">288</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Wilckens, K. A.</author><author>Hall, M. H.</author><author>Nebes, R. D.</author><author>Monk, T. H.</author><author>Buysse, D. J.</author></authors></contributors><auth-address>a Department of Psychiatry , University of Pittsburgh School of Medicine , USA.</auth-address><titles><title>Changes in Cognitive Performance Are Associated with Changes in Sleep in Older Adults With Insomnia</title><secondary-title>Behav Sleep Med</secondary-title><alt-title>Behavioral sleep medicine</alt-title></titles><periodical><full-title>Behav Sleep Med</full-title><abbr-1>Behavioral sleep medicine</abbr-1></periodical><alt-periodical><full-title>Behav Sleep Med</full-title><abbr-1>Behavioral sleep medicine</abbr-1></alt-periodical><pages>295-310</pages><volume>14</volume><number>3</number><edition>2015/09/01</edition><dates><year>2016</year><pub-dates><date>May-Jun</date></pub-dates></dates><isbn>1540-2010 (Electronic)
1540-2002 (Linking)</isbn><accession-num>26322904</accession-num><urls><related-urls><url>;(55) incorporated only the educational and behavioural components of CBT-I (sleep hygiene, stimulus control and sleep restriction) and Sun et al. ADDIN EN.CITE <EndNote><Cite><Author>Sun</Author><Year>2013</Year><RecNum>280</RecNum><DisplayText>(53)</DisplayText><record><rec-number>280</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr">280</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Sun, J.</author><author>Kang, J.</author><author>Wang, P.</author><author>Zeng, H.</author></authors></contributors><auth-address>School of Nursing, Central South University, Changsha, Hunan Province, China.</auth-address><titles><title>Self-relaxation training can improve sleep quality and cognitive functions in the older: a one-year randomised controlled trial</title><secondary-title>J Clin Nurs</secondary-title><alt-title>Journal of clinical nursing</alt-title></titles><pages>1270-80</pages><volume>22</volume><number>9-10</number><edition>2013/04/12</edition><keywords><keyword>Adolescent</keyword><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Aged, 80 and over</keyword><keyword>Analysis of Variance</keyword><keyword>Child</keyword><keyword>*Cognition</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Patient Education as Topic/*methods</keyword><keyword>*Relaxation Therapy</keyword><keyword>*Self Care</keyword><keyword>*Sleep</keyword><keyword>Surveys and Questionnaires</keyword><keyword>Young Adult</keyword></keywords><dates><year>2013</year><pub-dates><date>May</date></pub-dates></dates><isbn>1365-2702 (Electronic)
0962-1067 (Linking)</isbn><accession-num>23574290</accession-num><work-type>Randomized Controlled Trial
Research Support, Non-U.S. Gov't</work-type><urls><related-urls><url>;(53) combined sleep hygiene with relaxation techniques. Many of the included studies failed to provide sufficient details of the intervention components to enable replication, particularly for sleep restriction. A range of methods were used to deliver the intervention. Eight studies delivered the intervention in a group setting PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5EYXZpZHNvbjwvQXV0aG9yPjxZZWFyPjIwMDE8L1llYXI+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=
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5EYXZpZHNvbjwvQXV0aG9yPjxZZWFyPjIwMDE8L1llYXI+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=
ADDIN EN.CITE.DATA (48, 50, 53, 57, 58, 60-62). In three studies, the intervention was delivered by a clinician through individual face-to-face sessions PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5PbXZpazwvQXV0aG9yPjxZZWFyPjIwMDg8L1llYXI+PFJl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==
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5PbXZpazwvQXV0aG9yPjxZZWFyPjIwMDg8L1llYXI+PFJl
Y051bT4yNzI8L1JlY051bT48RGlzcGxheVRleHQ+KDUxLCA1NCwgNTkpPC9EaXNwbGF5VGV4dD48
cmVjb3JkPjxyZWMtbnVtYmVyPjI3MjwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBw
PSJFTiIgZGItaWQ9IjVwcndlNXNhMXN6MnNwZWVmd3I1dHgwb3hkdzlzenp4cGFzciI+MjcyPC9r
ZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3Jl
Zi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5PbXZpaywgUy48L2F1dGhvcj48
YXV0aG9yPlNpdmVydHNlbiwgQi48L2F1dGhvcj48YXV0aG9yPlBhbGxlc2VuLCBTLjwvYXV0aG9y
PjxhdXRob3I+QmpvcnZhdG4sIEIuPC9hdXRob3I+PGF1dGhvcj5IYXZpaywgTy4gRS48L2F1dGhv
cj48YXV0aG9yPk5vcmRodXMsIEkuIEguPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3Jz
PjxhdXRoLWFkZHJlc3M+RGVwYXJ0bWVudCBvZiBDbGluaWNhbCBQc3ljaG9sb2d5LCBVbml2ZXJz
aXR5IG9mIEJlcmdlbiwgQmVyZ2VuLCBOb3J3YXkuIHNpcmkub212aWtAcHN5a3AudWliLm5vPC9h
dXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+RGF5dGltZSBmdW5jdGlvbmluZyBpbiBvbGRlciBw
YXRpZW50cyBzdWZmZXJpbmcgZnJvbSBjaHJvbmljIGluc29tbmlhOiB0cmVhdG1lbnQgb3V0Y29t
ZSBpbiBhIHJhbmRvbWl6ZWQgY29udHJvbGxlZCB0cmlhbCBjb21wYXJpbmcgQ0JUIHdpdGggWm9w
aWNsb25lPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkJlaGF2IFJlcyBUaGVyPC9zZWNvbmRhcnkt
dGl0bGU+PGFsdC10aXRsZT5CZWhhdmlvdXIgcmVzZWFyY2ggYW5kIHRoZXJhcHk8L2FsdC10aXRs
ZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5CZWhhdiBSZXMgVGhlcjwvZnVsbC10
aXRsZT48YWJici0xPkJlaGF2aW91ciByZXNlYXJjaCBhbmQgdGhlcmFweTwvYWJici0xPjwvcGVy
aW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+QmVoYXYgUmVzIFRoZXI8L2Z1bGwt
dGl0bGU+PGFiYnItMT5CZWhhdmlvdXIgcmVzZWFyY2ggYW5kIHRoZXJhcHk8L2FiYnItMT48L2Fs
dC1wZXJpb2RpY2FsPjxwYWdlcz42MjMtNDE8L3BhZ2VzPjx2b2x1bWU+NDY8L3ZvbHVtZT48bnVt
YmVyPjU8L251bWJlcj48ZWRpdGlvbj4yMDA4LzA0LzE4PC9lZGl0aW9uPjxrZXl3b3Jkcz48a2V5
d29yZD5BZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPkF6YWJpY3ljbG8gQ29tcG91bmRzLyp0aGVyYXBl
dXRpYyB1c2U8L2tleXdvcmQ+PGtleXdvcmQ+KkNvZ25pdGl2ZSBUaGVyYXB5PC9rZXl3b3JkPjxr
ZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+
SHlwbm90aWNzIGFuZCBTZWRhdGl2ZXMvKnRoZXJhcGV1dGljIHVzZTwva2V5d29yZD48a2V5d29y
ZD5NYWxlPC9rZXl3b3JkPjxrZXl3b3JkPk1pZGRsZSBBZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPlBp
cGVyYXppbmVzLyp0aGVyYXBldXRpYyB1c2U8L2tleXdvcmQ+PGtleXdvcmQ+UHN5Y2hpYXRyaWMg
U3RhdHVzIFJhdGluZyBTY2FsZXM8L2tleXdvcmQ+PGtleXdvcmQ+UXVhbGl0eSBvZiBMaWZlPC9r
ZXl3b3JkPjxrZXl3b3JkPlNsZWVwIEluaXRpYXRpb24gYW5kIE1haW50ZW5hbmNlIERpc29yZGVy
cy8qdGhlcmFweTwva2V5d29yZD48a2V5d29yZD5UcmVhdG1lbnQgT3V0Y29tZTwva2V5d29yZD48
L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDA4PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+TWF5PC9k
YXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MDAwNS03OTY3IChQcmludCkmI3hEOzAwMDUt
Nzk2NyAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MTg0MTcwOTk8L2FjY2Vzc2lvbi1u
dW0+PHdvcmstdHlwZT5Db21wYXJhdGl2ZSBTdHVkeSYjeEQ7UmFuZG9taXplZCBDb250cm9sbGVk
IFRyaWFsJiN4RDtSZXNlYXJjaCBTdXBwb3J0LCBOb24tVS5TLiBHb3YmYXBvczt0PC93b3JrLXR5
cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9w
dWJtZWQvMTg0MTcwOTk8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVz
b3VyY2UtbnVtPjEwLjEwMTYvai5icmF0LjIwMDguMDIuMDEzPC9lbGVjdHJvbmljLXJlc291cmNl
LW51bT48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhv
cj5Td2Fuc29uPC9BdXRob3I+PFllYXI+MjAxMzwvWWVhcj48UmVjTnVtPjI0OTwvUmVjTnVtPjxy
ZWNvcmQ+PHJlYy1udW1iZXI+MjQ5PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9
IkVOIiBkYi1pZD0iNXByd2U1c2Exc3oyc3BlZWZ3cjV0eDBveGR3OXN6enhwYXNyIj4yNDk8L2tl
eT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVm
LXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPlN3YW5zb24sIEwuIE0uPC9hdXRo
b3I+PGF1dGhvcj5GbHlubiwgSC48L2F1dGhvcj48YXV0aG9yPkFkYW1zLU11bmR5LCBKLiBELjwv
YXV0aG9yPjxhdXRob3I+QXJtaXRhZ2UsIFIuPC9hdXRob3I+PGF1dGhvcj5Bcm5lZHQsIEouIFQu
PC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+RGVwYXJ0bWVu
dCBvZiBQc3ljaGlhdHJ5LCBVbml2ZXJzaXR5IG9mIE1pY2hpZ2FuLCBVU0EuIExNU3dhbkBtZWQu
dW1pY2guZWR1PC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+QW4gb3BlbiBwaWxvdCBvZiBj
b2duaXRpdmUtYmVoYXZpb3JhbCB0aGVyYXB5IGZvciBpbnNvbW5pYSBpbiB3b21lbiB3aXRoIHBv
c3RwYXJ0dW0gZGVwcmVzc2lvbjwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5CZWhhdiBTbGVlcCBN
ZWQ8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkJlaGF2aW9yYWwgc2xlZXAgbWVkaWNpbmU8
L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5CZWhhdiBTbGVlcCBN
ZWQ8L2Z1bGwtdGl0bGU+PGFiYnItMT5CZWhhdmlvcmFsIHNsZWVwIG1lZGljaW5lPC9hYmJyLTE+
PC9wZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5CZWhhdiBTbGVlcCBNZWQ8
L2Z1bGwtdGl0bGU+PGFiYnItMT5CZWhhdmlvcmFsIHNsZWVwIG1lZGljaW5lPC9hYmJyLTE+PC9h
bHQtcGVyaW9kaWNhbD48cGFnZXM+Mjk3LTMwNzwvcGFnZXM+PHZvbHVtZT4xMTwvdm9sdW1lPjxu
dW1iZXI+NDwvbnVtYmVyPjxlZGl0aW9uPjIwMTIvMTIvMTI8L2VkaXRpb24+PGtleXdvcmRzPjxr
ZXl3b3JkPkFkdWx0PC9rZXl3b3JkPjxrZXl3b3JkPipBZmZlY3Q8L2tleXdvcmQ+PGtleXdvcmQ+
KkNvZ25pdGl2ZSBUaGVyYXB5PC9rZXl3b3JkPjxrZXl3b3JkPkRlcHJlc3Npb24sIFBvc3RwYXJ0
dW0vKmNvbXBsaWNhdGlvbnM8L2tleXdvcmQ+PGtleXdvcmQ+RmF0aWd1ZS9jb21wbGljYXRpb25z
L3BzeWNob2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPkh1
bWFuczwva2V5d29yZD48a2V5d29yZD5QaWxvdCBQcm9qZWN0czwva2V5d29yZD48a2V5d29yZD5T
ZXZlcml0eSBvZiBJbGxuZXNzIEluZGV4PC9rZXl3b3JkPjxrZXl3b3JkPipTbGVlcDwva2V5d29y
ZD48a2V5d29yZD5TbGVlcCBJbml0aWF0aW9uIGFuZCBNYWludGVuYW5jZSBEaXNvcmRlcnMvY29t
cGxpY2F0aW9ucy9wc3ljaG9sb2d5Lyp0aGVyYXB5PC9rZXl3b3JkPjxrZXl3b3JkPlRyZWF0bWVu
dCBPdXRjb21lPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTM8L3llYXI+PC9k
YXRlcz48aXNibj4xNTQwLTIwMTAgKEVsZWN0cm9uaWMpJiN4RDsxNTQwLTIwMDIgKExpbmtpbmcp
PC9pc2JuPjxhY2Nlc3Npb24tbnVtPjIzMjE2MzczPC9hY2Nlc3Npb24tbnVtPjx3b3JrLXR5cGU+
UmVzZWFyY2ggU3VwcG9ydCwgTm9uLVUuUy4gR292JmFwb3M7dDwvd29yay10eXBlPjx1cmxzPjxy
ZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzIzMjE2
MzczPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4x
MC4xMDgwLzE1NDAyMDAyLjIwMTIuNjgzOTAyPC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48bGFu
Z3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5UYXlsb3I8
L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxSZWNOdW0+Mjg0PC9SZWNOdW0+PHJlY29yZD48cmVj
LW51bWJlcj4yODQ8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlk
PSI1cHJ3ZTVzYTFzejJzcGVlZndyNXR4MG94ZHc5c3p6eHBhc3IiPjI4NDwva2V5PjwvZm9yZWln
bi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29u
dHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+VGF5bG9yLCBELiBKLjwvYXV0aG9yPjxhdXRob3I+
WmltbWVybWFuLCBNLiBSLjwvYXV0aG9yPjxhdXRob3I+R2FyZG5lciwgQy4gRS48L2F1dGhvcj48
YXV0aG9yPldpbGxpYW1zLCBKLiBNLjwvYXV0aG9yPjxhdXRob3I+R3JpZXNlciwgRS4gQS48L2F1
dGhvcj48YXV0aG9yPlRhdHVtLCBKLiBJLjwvYXV0aG9yPjxhdXRob3I+QnJhbW93ZXRoLCBBLiBE
LjwvYXV0aG9yPjxhdXRob3I+RnJhbmNldGljaCwgSi4gTS48L2F1dGhvcj48YXV0aG9yPlJ1Z2dl
cm8sIEMuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+VW5p
dmVyc2l0eSBvZiBOb3J0aCBUZXhhcy4gRWxlY3Ryb25pYyBhZGRyZXNzOiBkanRheWxvckB1bnQu
ZWR1LiYjeEQ7VW5pdmVyc2l0eSBvZiBOb3J0aCBUZXhhcy4mI3hEO1RleGFzIFRlY2ggVW5pdmVy
c2l0eS4mI3hEO1RoZSBVbml2ZXJzaXR5IG9mIFRleGFzIEhlYWx0aCBTY2llbmNlIENlbnRlciBh
dCBTYW4gQW50b25pby4mI3hEO1dpbGZvcmQgSGFsbCBBbWJ1bGF0b3J5IFN1cmdpY2FsIENlbnRl
ci4mI3hEO1dyaWdodC1QYXR0ZXJzb24gTWVkaWNhbCBDZW50ZXIuJiN4RDtWQSBQaXR0c2J1cmdo
IEhlYWx0aGNhcmUgU3lzdGVtLiYjeEQ7VW5pdmVyc2l0eSBvZiBOb3J0aCBUZXhhcywgRGVwYXJ0
bWVudCBvZiBQc3ljaG9sb2d5LjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkEgcGlsb3Qg
cmFuZG9taXplZCBjb250cm9sbGVkIHRyaWFsIG9mIHRoZSBlZmZlY3RzIG9mIGNvZ25pdGl2ZS1i
ZWhhdmlvcmFsIHRoZXJhcHkgZm9yIGluc29tbmlhIG9uIHNsZWVwIGFuZCBkYXl0aW1lIGZ1bmN0
aW9uaW5nIGluIGNvbGxlZ2Ugc3R1ZGVudHM8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+QmVoYXYg
VGhlcjwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+QmVoYXZpb3IgdGhlcmFweTwvYWx0LXRp
dGxlPjwvdGl0bGVzPjxwYWdlcz4zNzYtODk8L3BhZ2VzPjx2b2x1bWU+NDU8L3ZvbHVtZT48bnVt
YmVyPjM8L251bWJlcj48ZWRpdGlvbj4yMDE0LzA0LzAxPC9lZGl0aW9uPjxrZXl3b3Jkcz48a2V5
d29yZD5BY3RpZ3JhcGh5L21ldGhvZHM8L2tleXdvcmQ+PGtleXdvcmQ+QWRvbGVzY2VudDwva2V5
d29yZD48a2V5d29yZD5BZHVsdDwva2V5d29yZD48a2V5d29yZD5Db2duaXRpb24vKnBoeXNpb2xv
Z3k8L2tleXdvcmQ+PGtleXdvcmQ+Q29nbml0aXZlIFRoZXJhcHkvKm1ldGhvZHM8L2tleXdvcmQ+
PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPkZvbGxvdy1VcCBTdHVkaWVzPC9rZXl3
b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3
b3JkPlNsZWVwLypwaHlzaW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPlNsZWVwIEluaXRpYXRpb24g
YW5kIE1haW50ZW5hbmNlIERpc29yZGVycy9kaWFnbm9zaXMvcHN5Y2hvbG9neS8qdGhlcmFweTwv
a2V5d29yZD48a2V5d29yZD4qU3R1ZGVudHM8L2tleXdvcmQ+PGtleXdvcmQ+U3VydmV5cyBhbmQg
UXVlc3Rpb25uYWlyZXM8L2tleXdvcmQ+PGtleXdvcmQ+VGltZSBGYWN0b3JzPC9rZXl3b3JkPjxr
ZXl3b3JkPlRyZWF0bWVudCBPdXRjb21lPC9rZXl3b3JkPjxrZXl3b3JkPllvdW5nIEFkdWx0PC9r
ZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTQ8L3llYXI+PHB1Yi1kYXRlcz48ZGF0
ZT5NYXk8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xODc4LTE4ODggKEVsZWN0cm9u
aWMpJiN4RDswMDA1LTc4OTQgKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjI0NjgwMjMy
PC9hY2Nlc3Npb24tbnVtPjx3b3JrLXR5cGU+UmFuZG9taXplZCBDb250cm9sbGVkIFRyaWFsJiN4
RDtSZXNlYXJjaCBTdXBwb3J0LCBOb24tVS5TLiBHb3YmYXBvczt0PC93b3JrLXR5cGU+PHVybHM+
PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMjQ2
ODAyMzI8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVt
PjEwLjEwMTYvai5iZXRoLjIwMTMuMTIuMDEwPC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48bGFu
Z3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPn==
ADDIN EN.CITE.DATA (51, 54, 59). Four studies combined individual face-to-face sessions with telephone consultations PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bcm5lZHQ8L0F1dGhvcj48WWVhcj4yMDA3PC9ZZWFyPjxS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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bcm5lZHQ8L0F1dGhvcj48WWVhcj4yMDA3PC9ZZWFyPjxS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ADDIN EN.CITE.DATA (45, 49, 55, 56). One study delivered the intervention via weekly telephone calls aided by written treatment modules PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bcm5lZHQ8L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFyPjxS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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bcm5lZHQ8L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFyPjxS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ADDIN EN.CITE.DATA (46). One study combined a self-help manual with three brief telephone consultations PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DYXNhdWx0PC9BdXRob3I+PFllYXI+MjAxNTwvWWVhcj48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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DYXNhdWx0PC9BdXRob3I+PFllYXI+MjAxNTwvWWVhcj48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ADDIN EN.CITE.DATA (47). One study utilised an online format PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5SaXR0ZXJiYW5kPC9BdXRob3I+PFllYXI+MjAxMjwvWWVh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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5SaXR0ZXJiYW5kPC9BdXRob3I+PFllYXI+MjAxMjwvWWVh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ADDIN EN.CITE.DATA (52). The length of treatment ranged from 3 to 9 weeks (mean length of treatment = 6 weeks). All of the studies indicated that a structured treatment protocol was used and eleven studies made explicit reference to the treatment being manualised PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bcm5lZHQ8L0F1dGhvcj48WWVhcj4yMDExPC9ZZWFyPjxS
ZWNOdW0+MjQyPC9SZWNOdW0+PERpc3BsYXlUZXh0Pig0NS00OCwgNTAsIDUyLCA1NCwgNTgsIDYw
LTYyKTwvRGlzcGxheVRleHQ+PHJlY29yZD48cmVjLW51bWJlcj4yNDI8L3JlYy1udW1iZXI+PGZv
cmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSI1cHJ3ZTVzYTFzejJzcGVlZndyNXR4MG94
ZHc5c3p6eHBhc3IiPjI0Mjwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3Vy
bmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+
QXJuZWR0LCBKLiBULjwvYXV0aG9yPjxhdXRob3I+Q29ucm95LCBELiBBLjwvYXV0aG9yPjxhdXRo
b3I+QXJtaXRhZ2UsIFIuPC9hdXRob3I+PGF1dGhvcj5Ccm93ZXIsIEsuIEouPC9hdXRob3I+PC9h
dXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+U2xlZXAgYW5kIENocm9ub3BoeXNp
b2xvZ3kgTGFib3JhdG9yeSwgRGVwYXJ0bWVudCBvZiBQc3ljaGlhdHJ5LCBVbml2ZXJzaXR5IG9m
IE1pY2hpZ2FuLCA0MjUwIFBseW1vdXRoIFJvYWQsIEFubiBBcmJvciwgTUkgNDgxMDktMjcwMCwg
VVNBLiB0YXJuZWR0QG1lZC51bWljaC5lZHU8L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5D
b2duaXRpdmUtYmVoYXZpb3JhbCB0aGVyYXB5IGZvciBpbnNvbW5pYSBpbiBhbGNvaG9sIGRlcGVu
ZGVudCBwYXRpZW50czogYSByYW5kb21pemVkIGNvbnRyb2xsZWQgcGlsb3QgdHJpYWw8L3RpdGxl
PjxzZWNvbmRhcnktdGl0bGU+QmVoYXYgUmVzIFRoZXI8L3NlY29uZGFyeS10aXRsZT48YWx0LXRp
dGxlPkJlaGF2aW91ciByZXNlYXJjaCBhbmQgdGhlcmFweTwvYWx0LXRpdGxlPjwvdGl0bGVzPjxw
ZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkJlaGF2IFJlcyBUaGVyPC9mdWxsLXRpdGxlPjxhYmJyLTE+
QmVoYXZpb3VyIHJlc2VhcmNoIGFuZCB0aGVyYXB5PC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxhbHQt
cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5CZWhhdiBSZXMgVGhlcjwvZnVsbC10aXRsZT48YWJici0x
PkJlaGF2aW91ciByZXNlYXJjaCBhbmQgdGhlcmFweTwvYWJici0xPjwvYWx0LXBlcmlvZGljYWw+
PHBhZ2VzPjIyNy0zMzwvcGFnZXM+PHZvbHVtZT40OTwvdm9sdW1lPjxudW1iZXI+NDwvbnVtYmVy
PjxlZGl0aW9uPjIwMTEvMDMvMDg8L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFkdWx0PC9r
ZXl3b3JkPjxrZXl3b3JkPkFsY29ob2xpc20vKmNvbXBsaWNhdGlvbnM8L2tleXdvcmQ+PGtleXdv
cmQ+KkNvZ25pdGl2ZSBUaGVyYXB5PC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5d29yZD48
a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48a2V5d29yZD5N
aWRkbGUgQWdlZDwva2V5d29yZD48a2V5d29yZD5QaWxvdCBQcm9qZWN0czwva2V5d29yZD48a2V5
d29yZD5Qb2x5c29tbm9ncmFwaHk8L2tleXdvcmQ+PGtleXdvcmQ+U2luZ2xlLUJsaW5kIE1ldGhv
ZDwva2V5d29yZD48a2V5d29yZD5TbGVlcCBJbml0aWF0aW9uIGFuZCBNYWludGVuYW5jZSBEaXNv
cmRlcnMvY29tcGxpY2F0aW9ucy8qdGhlcmFweTwva2V5d29yZD48a2V5d29yZD5UcmVhdG1lbnQg
T3V0Y29tZTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDExPC95ZWFyPjxwdWIt
ZGF0ZXM+PGRhdGU+QXByPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTg3My02MjJY
IChFbGVjdHJvbmljKSYjeEQ7MDAwNS03OTY3IChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51
bT4yMTM3NzE0NDwvYWNjZXNzaW9uLW51bT48d29yay10eXBlPlJhbmRvbWl6ZWQgQ29udHJvbGxl
ZCBUcmlhbCYjeEQ7UmVzZWFyY2ggU3VwcG9ydCwgTi5JLkguLCBFeHRyYW11cmFsPC93b3JrLXR5
cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9w
dWJtZWQvMjEzNzcxNDQ8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGN1c3RvbTI+MzA3Mzgx
MTwvY3VzdG9tMj48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTAxNi9qLmJyYXQuMjAxMS4w
Mi4wMDM8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwv
cmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPkFybmVkdDwvQXV0aG9yPjxZZWFyPjIwMTM8L1ll
YXI+PFJlY051bT4yOTM8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjI5MzwvcmVjLW51bWJl
cj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9IjVwcndlNXNhMXN6MnNwZWVmd3I1
dHgwb3hkdzlzenp4cGFzciI+MjkzPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9
IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1
dGhvcj5Bcm5lZHQsIEouIFQuPC9hdXRob3I+PGF1dGhvcj5DdWRkaWh5LCBMLjwvYXV0aG9yPjxh
dXRob3I+U3dhbnNvbiwgTC4gTS48L2F1dGhvcj48YXV0aG9yPlBpY2tldHQsIFMuPC9hdXRob3I+
PGF1dGhvcj5BaWtlbnMsIEouPC9hdXRob3I+PGF1dGhvcj5DaGVydmluLCBSLiBELjwvYXV0aG9y
PjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPlNsZWVwIGFuZCBDaHJvbm9w
aHlzaW9sb2d5IExhYm9yYXRvcnksIERlcGFydG1lbnQgb2YgUHN5Y2hpYXRyeSwgVW5pdmVyc2l0
eSBvZiBNaWNoaWdhbiwgQW5uIEFyYm9yLCBNSSA0ODEwOS0yNzAwLCBVU0EuIHRhcm5lZHRAdW1p
Y2guZWR1PC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+UmFuZG9taXplZCBjb250cm9sbGVk
IHRyaWFsIG9mIHRlbGVwaG9uZS1kZWxpdmVyZWQgY29nbml0aXZlIGJlaGF2aW9yYWwgdGhlcmFw
eSBmb3IgY2hyb25pYyBpbnNvbW5pYTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5TbGVlcDwvc2Vj
b25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+U2xlZXA8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9k
aWNhbD48ZnVsbC10aXRsZT5TbGVlcDwvZnVsbC10aXRsZT48YWJici0xPlNsZWVwPC9hYmJyLTE+
PC9wZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5TbGVlcDwvZnVsbC10aXRs
ZT48YWJici0xPlNsZWVwPC9hYmJyLTE+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+MzUzLTYyPC9w
YWdlcz48dm9sdW1lPjM2PC92b2x1bWU+PG51bWJlcj4zPC9udW1iZXI+PGVkaXRpb24+MjAxMy8w
My8wMjwvZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QWN0aXZpdGllcyBvZiBEYWlseSBMaXZp
bmc8L2tleXdvcmQ+PGtleXdvcmQ+QWR1bHQ8L2tleXdvcmQ+PGtleXdvcmQ+Q29nbml0aXZlIFRo
ZXJhcHkvKm1ldGhvZHM8L2tleXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3Jk
PkZvbGxvdy1VcCBTdHVkaWVzPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5
d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3b3JkPlBhdGllbnQgQ29tcGxpYW5jZTwva2V5d29yZD48
a2V5d29yZD5TbGVlcDwva2V5d29yZD48a2V5d29yZD5TbGVlcCBJbml0aWF0aW9uIGFuZCBNYWlu
dGVuYW5jZSBEaXNvcmRlcnMvcHN5Y2hvbG9neS8qdGhlcmFweTwva2V5d29yZD48a2V5d29yZD5T
dXJ2ZXlzIGFuZCBRdWVzdGlvbm5haXJlczwva2V5d29yZD48a2V5d29yZD4qVGVsZXBob25lPC9r
ZXl3b3JkPjxrZXl3b3JkPlRyZWF0bWVudCBPdXRjb21lPC9rZXl3b3JkPjwva2V5d29yZHM+PGRh
dGVzPjx5ZWFyPjIwMTM8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5NYXI8L2RhdGU+PC9wdWItZGF0
ZXM+PC9kYXRlcz48aXNibj4xNTUwLTkxMDkgKEVsZWN0cm9uaWMpJiN4RDswMTYxLTgxMDUgKExp
bmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjIzNDUwNzEyPC9hY2Nlc3Npb24tbnVtPjx3b3Jr
LXR5cGU+UmFuZG9taXplZCBDb250cm9sbGVkIFRyaWFsJiN4RDtSZXNlYXJjaCBTdXBwb3J0LCBO
LkkuSC4sIEV4dHJhbXVyYWw8L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0
cDovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8yMzQ1MDcxMjwvdXJsPjwvcmVsYXRlZC11
cmxzPjwvdXJscz48Y3VzdG9tMj4zNTcxNzQ2PC9jdXN0b20yPjxlbGVjdHJvbmljLXJlc291cmNl
LW51bT4xMC41NjY1L3NsZWVwLjI0NDg8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjxsYW5ndWFn
ZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPkNhc2F1bHQ8L0F1
dGhvcj48WWVhcj4yMDE1PC9ZZWFyPjxSZWNOdW0+MjU1PC9SZWNOdW0+PHJlY29yZD48cmVjLW51
bWJlcj4yNTU8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSI1
cHJ3ZTVzYTFzejJzcGVlZndyNXR4MG94ZHc5c3p6eHBhc3IiPjI1NTwva2V5PjwvZm9yZWlnbi1r
ZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJp
YnV0b3JzPjxhdXRob3JzPjxhdXRob3I+Q2FzYXVsdCwgTC48L2F1dGhvcj48YXV0aG9yPlNhdmFy
ZCwgSi48L2F1dGhvcj48YXV0aG9yPkl2ZXJzLCBILjwvYXV0aG9yPjxhdXRob3I+U2F2YXJkLCBN
LiBILjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPlNjaG9v
bCBvZiBQc3ljaG9sb2d5LCBVbml2ZXJzaXRlIExhdmFsLCBRdWViZWMsIFF1ZWJlYywgRzFWIDBB
NiwgQ2FuYWRhOyBDZW50cmUgZGUgcmVjaGVyY2hlIGR1IENIVSBkZSBRdWViZWMgYW5kIENlbnRy
ZSBkZSByZWNoZXJjaGUgc3VyIGxlIGNhbmNlciwgVW5pdmVyc2l0ZSBMYXZhbCwgMTEgQ290ZSBk
dSBQYWxhaXMsIFF1ZWJlYywgRzFSIDJKNiwgQ2FuYWRhOyBDZW50cmUgaG9zcGl0YWxpZXIgdW5p
dmVyc2l0YWlyZSAoQ0hVKSBkZSBRdWViZWMsIDExLCBDb3RlIGR1IFBhbGFpcywgUXVlYmVjLCBR
dWViZWMsIEcxUiAySjYsIENhbmFkYS4mI3hEO1NjaG9vbCBvZiBQc3ljaG9sb2d5LCBVbml2ZXJz
aXRlIExhdmFsLCBRdWViZWMsIFF1ZWJlYywgRzFWIDBBNiwgQ2FuYWRhOyBDZW50cmUgZGUgcmVj
aGVyY2hlIGR1IENIVSBkZSBRdWViZWMgYW5kIENlbnRyZSBkZSByZWNoZXJjaGUgc3VyIGxlIGNh
bmNlciwgVW5pdmVyc2l0ZSBMYXZhbCwgMTEgQ290ZSBkdSBQYWxhaXMsIFF1ZWJlYywgRzFSIDJK
NiwgQ2FuYWRhLiBFbGVjdHJvbmljIGFkZHJlc3M6IGpvc2VlLnNhdmFyZEBwc3kudWxhdmFsLmNh
LiYjeEQ7U2Nob29sIG9mIFBzeWNob2xvZ3ksIFVuaXZlcnNpdGUgTGF2YWwsIFF1ZWJlYywgUXVl
YmVjLCBHMVYgMEE2LCBDYW5hZGE7IENlbnRyZSBkZSByZWNoZXJjaGUgZHUgQ0hVIGRlIFF1ZWJl
YyBhbmQgQ2VudHJlIGRlIHJlY2hlcmNoZSBzdXIgbGUgY2FuY2VyLCBVbml2ZXJzaXRlIExhdmFs
LCAxMSBDb3RlIGR1IFBhbGFpcywgUXVlYmVjLCBHMVIgMko2LCBDYW5hZGEuJiN4RDtDZW50cmUg
ZGUgcmVjaGVyY2hlIGR1IENIVSBkZSBRdWViZWMgYW5kIENlbnRyZSBkZSByZWNoZXJjaGUgc3Vy
IGxlIGNhbmNlciwgVW5pdmVyc2l0ZSBMYXZhbCwgMTEgQ290ZSBkdSBQYWxhaXMsIFF1ZWJlYywg
RzFSIDJKNiwgQ2FuYWRhLjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkEgcmFuZG9taXpl
ZC1jb250cm9sbGVkIHRyaWFsIG9mIGFuIGVhcmx5IG1pbmltYWwgY29nbml0aXZlLWJlaGF2aW91
cmFsIHRoZXJhcHkgZm9yIGluc29tbmlhIGNvbW9yYmlkIHdpdGggY2FuY2VyPC90aXRsZT48c2Vj
b25kYXJ5LXRpdGxlPkJlaGF2IFJlcyBUaGVyPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5C
ZWhhdmlvdXIgcmVzZWFyY2ggYW5kIHRoZXJhcHk8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9k
aWNhbD48ZnVsbC10aXRsZT5CZWhhdiBSZXMgVGhlcjwvZnVsbC10aXRsZT48YWJici0xPkJlaGF2
aW91ciByZXNlYXJjaCBhbmQgdGhlcmFweTwvYWJici0xPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlv
ZGljYWw+PGZ1bGwtdGl0bGU+QmVoYXYgUmVzIFRoZXI8L2Z1bGwtdGl0bGU+PGFiYnItMT5CZWhh
dmlvdXIgcmVzZWFyY2ggYW5kIHRoZXJhcHk8L2FiYnItMT48L2FsdC1wZXJpb2RpY2FsPjxwYWdl
cz40NS01NDwvcGFnZXM+PHZvbHVtZT42Nzwvdm9sdW1lPjxlZGl0aW9uPjIwMTUvMDMvMTA8L2Vk
aXRpb24+PGRhdGVzPjx5ZWFyPjIwMTU8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5BcHI8L2RhdGU+
PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xODczLTYyMlggKEVsZWN0cm9uaWMpJiN4RDswMDA1
LTc5NjcgKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjI1NzQ2Nzc3PC9hY2Nlc3Npb24t
bnVtPjx3b3JrLXR5cGU+UmVzZWFyY2ggU3VwcG9ydCwgTm9uLVUuUy4gR292JmFwb3M7dDwvd29y
ay10eXBlPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5paC5n
b3YvcHVibWVkLzI1NzQ2Nzc3PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmlj
LXJlc291cmNlLW51bT4xMC4xMDE2L2ouYnJhdC4yMDE1LjAyLjAwMzwvZWxlY3Ryb25pYy1yZXNv
dXJjZS1udW0+PGxhbmd1YWdlPmVuZzwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxB
dXRob3I+SmFuc3NvbjwvQXV0aG9yPjxZZWFyPjIwMDU8L1llYXI+PFJlY051bT4yNjM8L1JlY051
bT48cmVjb3JkPjxyZWMtbnVtYmVyPjI2MzwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkg
YXBwPSJFTiIgZGItaWQ9IjVwcndlNXNhMXN6MnNwZWVmd3I1dHgwb3hkdzlzenp4cGFzciI+MjYz
PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8
L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5KYW5zc29uLCBNLjwvYXV0
aG9yPjxhdXRob3I+TGludG9uLCBTLiBKLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9y
cz48YXV0aC1hZGRyZXNzPkRlcGFydG1lbnQgb2YgT2NjdXBhdGlvbmFsIGFuZCBFbnZpcm9ubWVu
dGFsIE1lZGljaW5lLCBPcmVicm8gTWVkaWNhbCBDZW50ZXIsIFMtNzAxIDg1IE9yZWJybywgU3dl
ZGVuLjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkNvZ25pdGl2ZS1iZWhhdmlvcmFsIGdy
b3VwIHRoZXJhcHkgYXMgYW4gZWFybHkgaW50ZXJ2ZW50aW9uIGZvciBpbnNvbW5pYTogYSByYW5k
b21pemVkIGNvbnRyb2xsZWQgdHJpYWw8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+SiBPY2N1cCBS
ZWhhYmlsPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5Kb3VybmFsIG9mIG9jY3VwYXRpb25h
bCByZWhhYmlsaXRhdGlvbjwvYWx0LXRpdGxlPjwvdGl0bGVzPjxhbHQtcGVyaW9kaWNhbD48ZnVs
bC10aXRsZT5Kb3VybmFsIG9mIE9jY3VwYXRpb25hbCBSZWhhYmlsaXRhdGlvbjwvZnVsbC10aXRs
ZT48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz4xNzctOTA8L3BhZ2VzPjx2b2x1bWU+MTU8L3ZvbHVt
ZT48bnVtYmVyPjI8L251bWJlcj48ZWRpdGlvbj4yMDA1LzA0LzIzPC9lZGl0aW9uPjxrZXl3b3Jk
cz48a2V5d29yZD5BZG9sZXNjZW50PC9rZXl3b3JkPjxrZXl3b3JkPkFkdWx0PC9rZXl3b3JkPjxr
ZXl3b3JkPkFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+QW54aWV0eTwva2V5d29yZD48a2V5d29yZD5B
dHRpdHVkZSB0byBIZWFsdGg8L2tleXdvcmQ+PGtleXdvcmQ+KkNvZ25pdGl2ZSBUaGVyYXB5PC9r
ZXl3b3JkPjxrZXl3b3JkPkRlcHJlc3Npb248L2tleXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3
b3JkPjxrZXl3b3JkPkZvbGxvdy1VcCBTdHVkaWVzPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwv
a2V5d29yZD48a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3b3JkPk1pZGRsZSBBZ2VkPC9rZXl3
b3JkPjxrZXl3b3JkPipQYXRpZW50IEVkdWNhdGlvbiBhcyBUb3BpYzwva2V5d29yZD48a2V5d29y
ZD4qUHN5Y2hvdGhlcmFweSwgR3JvdXA8L2tleXdvcmQ+PGtleXdvcmQ+U2xlZXAgSW5pdGlhdGlv
biBhbmQgTWFpbnRlbmFuY2UgRGlzb3JkZXJzL3BoeXNpb3BhdGhvbG9neS8qdGhlcmFweTwva2V5
d29yZD48a2V5d29yZD5TdXJ2ZXlzIGFuZCBRdWVzdGlvbm5haXJlczwva2V5d29yZD48a2V5d29y
ZD5UZWFjaGluZyBNYXRlcmlhbHMvc3VwcGx5ICZhbXA7IGRpc3RyaWJ1dGlvbjwva2V5d29yZD48
a2V5d29yZD5UaW1lIEZhY3RvcnM8L2tleXdvcmQ+PGtleXdvcmQ+VHJlYXRtZW50IE91dGNvbWU8
L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAwNTwveWVhcj48cHViLWRhdGVzPjxk
YXRlPkp1bjwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjEwNTMtMDQ4NyAoUHJpbnQp
JiN4RDsxMDUzLTA0ODcgKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjE1ODQ0Njc1PC9h
Y2Nlc3Npb24tbnVtPjx3b3JrLXR5cGU+Q2xpbmljYWwgVHJpYWwmI3hEO1JhbmRvbWl6ZWQgQ29u
dHJvbGxlZCBUcmlhbCYjeEQ7UmVzZWFyY2ggU3VwcG9ydCwgTm9uLVUuUy4gR292JmFwb3M7dDwv
d29yay10eXBlPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5p
aC5nb3YvcHVibWVkLzE1ODQ0Njc1PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxsYW5ndWFn
ZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPkxhbWk8L0F1dGhv
cj48WWVhcj4yMDE2PC9ZZWFyPjxSZWNOdW0+MjY2PC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJl
cj4yNjY8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSI1cHJ3
ZTVzYTFzejJzcGVlZndyNXR4MG94ZHc5c3p6eHBhc3IiPjI2Njwva2V5PjwvZm9yZWlnbi1rZXlz
PjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0
b3JzPjxhdXRob3JzPjxhdXRob3I+TGFtaSwgTS4gSi48L2F1dGhvcj48YXV0aG9yPk1hcnRpbmV6
LCBNLiBQLjwvYXV0aG9yPjxhdXRob3I+U2FuY2hleiwgQS4gSS48L2F1dGhvcj48YXV0aG9yPk1p
cm8sIEUuPC9hdXRob3I+PGF1dGhvcj5EaWVuZXIsIEYuIE4uPC9hdXRob3I+PGF1dGhvcj5QcmFk
b3MsIEcuPC9hdXRob3I+PGF1dGhvcj5HdXptYW4sIE0uIEEuPC9hdXRob3I+PC9hdXRob3JzPjwv
Y29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+RGVwYXJ0bWVudCBvZiBQZXJzb25hbGl0eSwgQXNz
ZXNzbWVudCwgYW5kIFBzeWNob2xvZ2ljYWwgVHJlYXRtZW50LCBGYWN1bHR5IG9mIFBzeWNob2xv
Z3ksIFVuaXZlcnNpdHkgb2YgR3JhbmFkYSwgR3JhbmFkYSwgU3BhaW4uJiN4RDtNaW5kLCBCcmFp
biBhbmQgQmVoYXZpb3IgUmVzZWFyY2ggQ2VudGVyIChDSU1DWUMpLCBVbml2ZXJzaXR5IG9mIEdy
YW5hZGEsIEdyYW5hZGEsIFNwYWluLiYjeEQ7SW50ZXJuYWwgTWVkaWNpbmUgU2VydmljZSwgVmly
Z2VuIGRlIGxhcyBOaWV2ZXMgVW5pdmVyc2l0eSBIb3NwaXRhbCwgYW5kIFJoZXVtYXRvbG9neSBT
ZXJ2aWNlLCBWaXJnZW4gZGUgbGFzIE5pZXZlcyBVbml2ZXJzaXR5IEhvc3BpdGFsLCBHcmFuYWRh
LCBTcGFpbi48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5HZW5kZXIgRGlmZmVyZW5jZXMg
aW4gUGF0aWVudHMgd2l0aCBGaWJyb215YWxnaWEgVW5kZXJnb2luZyBDb2duaXRpdmUtQmVoYXZp
b3JhbCBUaGVyYXB5IGZvciBJbnNvbW5pYTogUHJlbGltaW5hcnkgRGF0YTwvdGl0bGU+PHNlY29u
ZGFyeS10aXRsZT5QYWluIFByYWN0PC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5QYWluIHBy
YWN0aWNlIDogdGhlIG9mZmljaWFsIGpvdXJuYWwgb2YgV29ybGQgSW5zdGl0dXRlIG9mIFBhaW48
L2FsdC10aXRsZT48L3RpdGxlcz48cGFnZXM+RTIzLTM0PC9wYWdlcz48dm9sdW1lPjE2PC92b2x1
bWU+PG51bWJlcj4yPC9udW1iZXI+PGVkaXRpb24+MjAxNi8wMi8wNDwvZWRpdGlvbj48ZGF0ZXM+
PHllYXI+MjAxNjwveWVhcj48cHViLWRhdGVzPjxkYXRlPkZlYjwvZGF0ZT48L3B1Yi1kYXRlcz48
L2RhdGVzPjxpc2JuPjE1MzMtMjUwMCAoRWxlY3Ryb25pYykmI3hEOzE1MzAtNzA4NSAoTGlua2lu
Zyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MjY4NDExOTg8L2FjY2Vzc2lvbi1udW0+PHdvcmstdHlw
ZT5SZXNlYXJjaCBTdXBwb3J0LCBOb24tVS5TLiBHb3YmYXBvczt0PC93b3JrLXR5cGU+PHVybHM+
PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMjY4
NDExOTg8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVt
PjEwLjExMTEvcGFwci4xMjQxMTwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PGxhbmd1YWdlPmVu
ZzwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+TWlybzwvQXV0aG9yPjxZ
ZWFyPjIwMTE8L1llYXI+PFJlY051bT4yNzE8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjI3
MTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9IjVwcndlNXNh
MXN6MnNwZWVmd3I1dHgwb3hkdzlzenp4cGFzciI+MjcxPC9rZXk+PC9mb3JlaWduLWtleXM+PHJl
Zi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+
PGF1dGhvcnM+PGF1dGhvcj5NaXJvLCBFLjwvYXV0aG9yPjxhdXRob3I+THVwaWFuZXosIEouPC9h
dXRob3I+PGF1dGhvcj5NYXJ0aW5leiwgTS4gUC48L2F1dGhvcj48YXV0aG9yPlNhbmNoZXosIEEu
IEkuPC9hdXRob3I+PGF1dGhvcj5EaWF6LVBpZWRyYSwgQy48L2F1dGhvcj48YXV0aG9yPkd1em1h
biwgTS4gQS48L2F1dGhvcj48YXV0aG9yPkJ1ZWxhLUNhc2FsLCBHLjwvYXV0aG9yPjwvYXV0aG9y
cz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPlVuaXZlcnNpZGFkIGRlIEdyYW5hZGEsIENh
bXB1cyBVbml2ZXJzaXRhcmlvIGRlIGxhIENhcnR1amEsIHMvbiwgQ1AuIDE4MDcxLCBHcmFuYWRh
LCBTcGFpbi4gZW1pcm9AdWdyLmU8L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5Db2duaXRp
dmUtYmVoYXZpb3JhbCB0aGVyYXB5IGZvciBpbnNvbW5pYSBpbXByb3ZlcyBhdHRlbnRpb25hbCBm
dW5jdGlvbiBpbiBmaWJyb215YWxnaWEgc3luZHJvbWU6IGEgcGlsb3QsIHJhbmRvbWl6ZWQgY29u
dHJvbGxlZCB0cmlhbDwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5KIEhlYWx0aCBQc3ljaG9sPC9z
ZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5Kb3VybmFsIG9mIGhlYWx0aCBwc3ljaG9sb2d5PC9h
bHQtdGl0bGU+PC90aXRsZXM+PHBhZ2VzPjc3MC04MjwvcGFnZXM+PHZvbHVtZT4xNjwvdm9sdW1l
PjxudW1iZXI+NTwvbnVtYmVyPjxlZGl0aW9uPjIwMTEvMDIvMjU8L2VkaXRpb24+PGtleXdvcmRz
PjxrZXl3b3JkPkFjdGl2aXRpZXMgb2YgRGFpbHkgTGl2aW5nL3BzeWNob2xvZ3k8L2tleXdvcmQ+
PGtleXdvcmQ+QWR1bHQ8L2tleXdvcmQ+PGtleXdvcmQ+QXR0ZW50aW9uPC9rZXl3b3JkPjxrZXl3
b3JkPipDb2duaXRpdmUgVGhlcmFweS9tZXRob2RzPC9rZXl3b3JkPjxrZXl3b3JkPkV4ZWN1dGl2
ZSBGdW5jdGlvbjwva2V5d29yZD48a2V5d29yZD5GZW1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+Rmli
cm9teWFsZ2lhL2NvbXBsaWNhdGlvbnMvcHN5Y2hvbG9neS8qdGhlcmFweTwva2V5d29yZD48a2V5
d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+TWlkZGxlIEFnZWQ8L2tleXdvcmQ+PGtleXdv
cmQ+TmV1cm9wc3ljaG9sb2dpY2FsIFRlc3RzPC9rZXl3b3JkPjxrZXl3b3JkPlBpbG90IFByb2pl
Y3RzPC9rZXl3b3JkPjxrZXl3b3JkPlNsZWVwPC9rZXl3b3JkPjxrZXl3b3JkPlNsZWVwIEluaXRp
YXRpb24gYW5kIE1haW50ZW5hbmNlIERpc29yZGVycy9jb21wbGljYXRpb25zL3BzeWNob2xvZ3kv
KnRoZXJhcHk8L2tleXdvcmQ+PGtleXdvcmQ+U3VydmV5cyBhbmQgUXVlc3Rpb25uYWlyZXM8L2tl
eXdvcmQ+PGtleXdvcmQ+VHJlYXRtZW50IE91dGNvbWU8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0
ZXM+PHllYXI+MjAxMTwveWVhcj48cHViLWRhdGVzPjxkYXRlPkp1bDwvZGF0ZT48L3B1Yi1kYXRl
cz48L2RhdGVzPjxpc2JuPjE0NjEtNzI3NyAoRWxlY3Ryb25pYykmI3hEOzEzNTktMTA1MyAoTGlu
a2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MjEzNDYwMjA8L2FjY2Vzc2lvbi1udW0+PHdvcmst
dHlwZT5SYW5kb21pemVkIENvbnRyb2xsZWQgVHJpYWwmI3hEO1Jlc2VhcmNoIFN1cHBvcnQsIE5v
bi1VLlMuIEdvdiZhcG9zO3Q8L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0
cDovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8yMTM0NjAyMDwvdXJsPjwvcmVsYXRlZC11
cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTE3Ny8xMzU5MTA1MzEwMzkw
NTQ0PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3Jl
Y29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5RdWVzbmVsPC9BdXRob3I+PFllYXI+MjAwMzwvWWVh
cj48UmVjTnVtPjI3NjwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+Mjc2PC9yZWMtbnVtYmVy
Pjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iNXByd2U1c2Exc3oyc3BlZWZ3cjV0
eDBveGR3OXN6enhwYXNyIj4yNzY8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0i
Sm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0
aG9yPlF1ZXNuZWwsIEMuPC9hdXRob3I+PGF1dGhvcj5TYXZhcmQsIEouPC9hdXRob3I+PGF1dGhv
cj5TaW1hcmQsIFMuPC9hdXRob3I+PGF1dGhvcj5JdmVycywgSC48L2F1dGhvcj48YXV0aG9yPk1v
cmluLCBDLiBNLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNz
PlNjaG9vbCBvZiBQc3ljaG9sb2d5IGFuZCBDYW5jZXIgUmVzZWFyY2ggQ2VudHJlLCBVbml2ZXJz
aXRlIExhdmFsLCBRdWViZWMsIFF1ZWJlYywgQ2FuYWRhLjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+
PHRpdGxlPkVmZmljYWN5IG9mIGNvZ25pdGl2ZS1iZWhhdmlvcmFsIHRoZXJhcHkgZm9yIGluc29t
bmlhIGluIHdvbWVuIHRyZWF0ZWQgZm9yIG5vbm1ldGFzdGF0aWMgYnJlYXN0IGNhbmNlcjwvdGl0
bGU+PHNlY29uZGFyeS10aXRsZT5KIENvbnN1bHQgQ2xpbiBQc3ljaG9sPC9zZWNvbmRhcnktdGl0
bGU+PGFsdC10aXRsZT5Kb3VybmFsIG9mIGNvbnN1bHRpbmcgYW5kIGNsaW5pY2FsIHBzeWNob2xv
Z3k8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5KIENvbnN1bHQg
Q2xpbiBQc3ljaG9sPC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48cGFnZXM+MTg5LTIwMDwvcGFn
ZXM+PHZvbHVtZT43MTwvdm9sdW1lPjxudW1iZXI+MTwvbnVtYmVyPjxlZGl0aW9uPjIwMDMvMDIv
Mjc8L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFkdWx0PC9rZXl3b3JkPjxrZXl3b3JkPkFn
ZWQ8L2tleXdvcmQ+PGtleXdvcmQ+QnJlYXN0IE5lb3BsYXNtcy8qcHN5Y2hvbG9neTwva2V5d29y
ZD48a2V5d29yZD5Db2duaXRpdmUgVGhlcmFweS8qbWV0aG9kczwva2V5d29yZD48a2V5d29yZD5G
ZW1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPk1pZGRsZSBB
Z2VkPC9rZXl3b3JkPjxrZXl3b3JkPlBvbHlzb21ub2dyYXBoeTwva2V5d29yZD48a2V5d29yZD5R
dWFsaXR5IG9mIExpZmU8L2tleXdvcmQ+PGtleXdvcmQ+U2xlZXAgSW5pdGlhdGlvbiBhbmQgTWFp
bnRlbmFuY2UgRGlzb3JkZXJzL2RpYWdub3Npcy8qZXRpb2xvZ3kvKnRoZXJhcHk8L2tleXdvcmQ+
PGtleXdvcmQ+U3VydmV5cyBhbmQgUXVlc3Rpb25uYWlyZXM8L2tleXdvcmQ+PC9rZXl3b3Jkcz48
ZGF0ZXM+PHllYXI+MjAwMzwveWVhcj48cHViLWRhdGVzPjxkYXRlPkZlYjwvZGF0ZT48L3B1Yi1k
YXRlcz48L2RhdGVzPjxpc2JuPjAwMjItMDA2WCAoUHJpbnQpJiN4RDswMDIyLTAwNlggKExpbmtp
bmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjEyNjAyNDM5PC9hY2Nlc3Npb24tbnVtPjx3b3JrLXR5
cGU+Q2xpbmljYWwgVHJpYWwmI3hEO1Jlc2VhcmNoIFN1cHBvcnQsIE5vbi1VLlMuIEdvdiZhcG9z
O3Q8L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5s
bS5uaWguZ292L3B1Ym1lZC8xMjYwMjQzOTwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48bGFu
Z3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5SaXR0ZXJi
YW5kPC9BdXRob3I+PFllYXI+MjAxMjwvWWVhcj48UmVjTnVtPjI3NzwvUmVjTnVtPjxyZWNvcmQ+
PHJlYy1udW1iZXI+Mjc3PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBk
Yi1pZD0iNXByd2U1c2Exc3oyc3BlZWZ3cjV0eDBveGR3OXN6enhwYXNyIj4yNzc8L2tleT48L2Zv
cmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+
PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPlJpdHRlcmJhbmQsIEwuIE0uPC9hdXRob3I+
PGF1dGhvcj5CYWlsZXksIEUuIFQuPC9hdXRob3I+PGF1dGhvcj5UaG9ybmRpa2UsIEYuIFAuPC9h
dXRob3I+PGF1dGhvcj5Mb3JkLCBILiBSLjwvYXV0aG9yPjxhdXRob3I+RmFycmVsbC1DYXJuYWhh
biwgTC48L2F1dGhvcj48YXV0aG9yPkJhdW0sIEwuIEQuPC9hdXRob3I+PC9hdXRob3JzPjwvY29u
dHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+RGVwYXJ0bWVudCBvZiBQc3ljaGlhdHJ5IGFuZCBOZXVy
b2JlaGF2aW9yYWwgU2NpZW5jZXMsIFVuaXZlcnNpdHkgb2YgVmlyZ2luaWEgSGVhbHRoIFN5c3Rl
bSwgQ2hhcmxvdHRlc3ZpbGxlLCBWQSAyMjkwOCwgVVNBLiBsZWVyQHZpcmdpbmlhLmVkdTwvYXV0
aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkluaXRpYWwgZXZhbHVhdGlvbiBvZiBhbiBJbnRlcm5l
dCBpbnRlcnZlbnRpb24gdG8gaW1wcm92ZSB0aGUgc2xlZXAgb2YgY2FuY2VyIHN1cnZpdm9ycyB3
aXRoIGluc29tbmlhPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPlBzeWNob29uY29sb2d5PC9zZWNv
bmRhcnktdGl0bGU+PGFsdC10aXRsZT5Qc3ljaG8tb25jb2xvZ3k8L2FsdC10aXRsZT48L3RpdGxl
cz48cGFnZXM+Njk1LTcwNTwvcGFnZXM+PHZvbHVtZT4yMTwvdm9sdW1lPjxudW1iZXI+NzwvbnVt
YmVyPjxlZGl0aW9uPjIwMTEvMDUvMDQ8L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFkdWx0
PC9rZXl3b3JkPjxrZXl3b3JkPkNvZ25pdGl2ZSBUaGVyYXB5LyptZXRob2RzPC9rZXl3b3JkPjxr
ZXl3b3JkPkZhdGlndWUvcHN5Y2hvbG9neS90aGVyYXB5PC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFs
ZTwva2V5d29yZD48a2V5d29yZD5Gb2xsb3ctVXAgU3R1ZGllczwva2V5d29yZD48a2V5d29yZD5I
dW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+KkludGVybmV0PC9rZXl3b3JkPjxrZXl3b3JkPk1hbGU8
L2tleXdvcmQ+PGtleXdvcmQ+TWlkZGxlIEFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+TmVvcGxhc21z
Lypjb21wbGljYXRpb25zL3BzeWNob2xvZ3kvKnRoZXJhcHk8L2tleXdvcmQ+PGtleXdvcmQ+UGF0
aWVudCBFZHVjYXRpb24gYXMgVG9waWMvbWV0aG9kczwva2V5d29yZD48a2V5d29yZD5RdWFsaXR5
IG9mIExpZmUvcHN5Y2hvbG9neTwva2V5d29yZD48a2V5d29yZD5TZXZlcml0eSBvZiBJbGxuZXNz
IEluZGV4PC9rZXl3b3JkPjxrZXl3b3JkPlNsZWVwIEluaXRpYXRpb24gYW5kIE1haW50ZW5hbmNl
IERpc29yZGVycy8qZXRpb2xvZ3kvcHN5Y2hvbG9neS8qdGhlcmFweTwva2V5d29yZD48a2V5d29y
ZD5TdHJlc3MsIFBzeWNob2xvZ2ljYWw8L2tleXdvcmQ+PGtleXdvcmQ+U3Vydml2b3JzLypwc3lj
aG9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPlRoZXJhcHksIENvbXB1dGVyLUFzc2lzdGVkLyptZXRo
b2RzPC9rZXl3b3JkPjxrZXl3b3JkPlRyZWF0bWVudCBPdXRjb21lPC9rZXl3b3JkPjwva2V5d29y
ZHM+PGRhdGVzPjx5ZWFyPjIwMTI8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5KdWw8L2RhdGU+PC9w
dWItZGF0ZXM+PC9kYXRlcz48aXNibj4xMDk5LTE2MTEgKEVsZWN0cm9uaWMpJiN4RDsxMDU3LTky
NDkgKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjIxNTM4Njc4PC9hY2Nlc3Npb24tbnVt
Pjx3b3JrLXR5cGU+UmFuZG9taXplZCBDb250cm9sbGVkIFRyaWFsJiN4RDtSZXNlYXJjaCBTdXBw
b3J0LCBOLkkuSC4sIEV4dHJhbXVyYWwmI3hEO1Jlc2VhcmNoIFN1cHBvcnQsIE5vbi1VLlMuIEdv
diZhcG9zO3Q8L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5u
Y2JpLm5sbS5uaWguZ292L3B1Ym1lZC8yMTUzODY3ODwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJs
cz48Y3VzdG9tMj4zNDI0MjcwPC9jdXN0b20yPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4x
MDAyL3Bvbi4xOTY5PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48bGFuZ3VhZ2U+ZW5nPC9sYW5n
dWFnZT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5TaW1laXQ8L0F1dGhvcj48WWVhcj4y
MDA0PC9ZZWFyPjxSZWNOdW0+Mjc5PC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj4yNzk8L3Jl
Yy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSI1cHJ3ZTVzYTFzejJz
cGVlZndyNXR4MG94ZHc5c3p6eHBhc3IiPjI3OTwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlw
ZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRo
b3JzPjxhdXRob3I+U2ltZWl0LCBSLjwvYXV0aG9yPjxhdXRob3I+RGVjaywgUi48L2F1dGhvcj48
YXV0aG9yPkNvbnRhLU1hcngsIEIuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxh
dXRoLWFkZHJlc3M+Um9wZXJzYmVyZ2tsaW5payBSYXR6ZWJ1cmcsIFJvcGVyc2JlcmcgNDcsIDIz
OTA5IFJhdHplYnVyZywgR2VybWFueS4gaW5mb0Bya3J6LmRlPC9hdXRoLWFkZHJlc3M+PHRpdGxl
cz48dGl0bGU+U2xlZXAgbWFuYWdlbWVudCB0cmFpbmluZyBmb3IgY2FuY2VyIHBhdGllbnRzIHdp
dGggaW5zb21uaWE8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+U3VwcG9ydCBDYXJlIENhbmNlcjwv
c2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+U3VwcG9ydGl2ZSBjYXJlIGluIGNhbmNlciA6IG9m
ZmljaWFsIGpvdXJuYWwgb2YgdGhlIE11bHRpbmF0aW9uYWwgQXNzb2NpYXRpb24gb2YgU3VwcG9y
dGl2ZSBDYXJlIGluIENhbmNlcjwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwYWdlcz4xNzYtODM8L3Bh
Z2VzPjx2b2x1bWU+MTI8L3ZvbHVtZT48bnVtYmVyPjM8L251bWJlcj48ZWRpdGlvbj4yMDA0LzAy
LzA1PC9lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5BdHRpdHVkZSB0byBIZWFsdGg8L2tleXdv
cmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPkhlYWx0aCBDYXJlIFN1cnZleXM8
L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+
PGtleXdvcmQ+TWlkZGxlIEFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+TmVvcGxhc21zLypjb21wbGlj
YXRpb25zL3BzeWNob2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+UGF0aWVudCBFZHVjYXRpb24gYXMg
VG9waWMvKm1ldGhvZHM8L2tleXdvcmQ+PGtleXdvcmQ+UHJvZ3JhbSBFdmFsdWF0aW9uPC9rZXl3
b3JkPjxrZXl3b3JkPlF1YWxpdHkgb2YgTGlmZTwva2V5d29yZD48a2V5d29yZD5SZWxheGF0aW9u
IFRoZXJhcHkvKmVkdWNhdGlvbjwva2V5d29yZD48a2V5d29yZD5TbGVlcCBJbml0aWF0aW9uIGFu
ZCBNYWludGVuYW5jZSBEaXNvcmRlcnMvcHJldmVudGlvbiAmYW1wOyBjb250cm9sLypyZWhhYmls
aXRhdGlvbjwva2V5d29yZD48a2V5d29yZD5TdXJ2ZXlzIGFuZCBRdWVzdGlvbm5haXJlczwva2V5
d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDA0PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+
TWFyPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MDk0MS00MzU1IChQcmludCkmI3hE
OzA5NDEtNDM1NSAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MTQ3NjA1NDI8L2FjY2Vz
c2lvbi1udW0+PHdvcmstdHlwZT5DbGluaWNhbCBUcmlhbCYjeEQ7Q29udHJvbGxlZCBDbGluaWNh
bCBUcmlhbCYjeEQ7UmVzZWFyY2ggU3VwcG9ydCwgTm9uLVUuUy4gR292JmFwb3M7dDwvd29yay10
eXBlPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5paC5nb3Yv
cHVibWVkLzE0NzYwNTQyPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJl
c291cmNlLW51bT4xMC4xMDA3L3MwMDUyMC0wMDQtMDU5NC01PC9lbGVjdHJvbmljLXJlc291cmNl
LW51bT48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhv
cj5UYXlsb3I8L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxSZWNOdW0+Mjg0PC9SZWNOdW0+PHJl
Y29yZD48cmVjLW51bWJlcj4yODQ8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0i
RU4iIGRiLWlkPSI1cHJ3ZTVzYTFzejJzcGVlZndyNXR4MG94ZHc5c3p6eHBhc3IiPjI4NDwva2V5
PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYt
dHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+VGF5bG9yLCBELiBKLjwvYXV0aG9y
PjxhdXRob3I+WmltbWVybWFuLCBNLiBSLjwvYXV0aG9yPjxhdXRob3I+R2FyZG5lciwgQy4gRS48
L2F1dGhvcj48YXV0aG9yPldpbGxpYW1zLCBKLiBNLjwvYXV0aG9yPjxhdXRob3I+R3JpZXNlciwg
RS4gQS48L2F1dGhvcj48YXV0aG9yPlRhdHVtLCBKLiBJLjwvYXV0aG9yPjxhdXRob3I+QnJhbW93
ZXRoLCBBLiBELjwvYXV0aG9yPjxhdXRob3I+RnJhbmNldGljaCwgSi4gTS48L2F1dGhvcj48YXV0
aG9yPlJ1Z2dlcm8sIEMuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFk
ZHJlc3M+VW5pdmVyc2l0eSBvZiBOb3J0aCBUZXhhcy4gRWxlY3Ryb25pYyBhZGRyZXNzOiBkanRh
eWxvckB1bnQuZWR1LiYjeEQ7VW5pdmVyc2l0eSBvZiBOb3J0aCBUZXhhcy4mI3hEO1RleGFzIFRl
Y2ggVW5pdmVyc2l0eS4mI3hEO1RoZSBVbml2ZXJzaXR5IG9mIFRleGFzIEhlYWx0aCBTY2llbmNl
IENlbnRlciBhdCBTYW4gQW50b25pby4mI3hEO1dpbGZvcmQgSGFsbCBBbWJ1bGF0b3J5IFN1cmdp
Y2FsIENlbnRlci4mI3hEO1dyaWdodC1QYXR0ZXJzb24gTWVkaWNhbCBDZW50ZXIuJiN4RDtWQSBQ
aXR0c2J1cmdoIEhlYWx0aGNhcmUgU3lzdGVtLiYjeEQ7VW5pdmVyc2l0eSBvZiBOb3J0aCBUZXhh
cywgRGVwYXJ0bWVudCBvZiBQc3ljaG9sb2d5LjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxl
PkEgcGlsb3QgcmFuZG9taXplZCBjb250cm9sbGVkIHRyaWFsIG9mIHRoZSBlZmZlY3RzIG9mIGNv
Z25pdGl2ZS1iZWhhdmlvcmFsIHRoZXJhcHkgZm9yIGluc29tbmlhIG9uIHNsZWVwIGFuZCBkYXl0
aW1lIGZ1bmN0aW9uaW5nIGluIGNvbGxlZ2Ugc3R1ZGVudHM8L3RpdGxlPjxzZWNvbmRhcnktdGl0
bGU+QmVoYXYgVGhlcjwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+QmVoYXZpb3IgdGhlcmFw
eTwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwYWdlcz4zNzYtODk8L3BhZ2VzPjx2b2x1bWU+NDU8L3Zv
bHVtZT48bnVtYmVyPjM8L251bWJlcj48ZWRpdGlvbj4yMDE0LzA0LzAxPC9lZGl0aW9uPjxrZXl3
b3Jkcz48a2V5d29yZD5BY3RpZ3JhcGh5L21ldGhvZHM8L2tleXdvcmQ+PGtleXdvcmQ+QWRvbGVz
Y2VudDwva2V5d29yZD48a2V5d29yZD5BZHVsdDwva2V5d29yZD48a2V5d29yZD5Db2duaXRpb24v
KnBoeXNpb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+Q29nbml0aXZlIFRoZXJhcHkvKm1ldGhvZHM8
L2tleXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPkZvbGxvdy1VcCBTdHVk
aWVzPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5NYWxlPC9rZXl3
b3JkPjxrZXl3b3JkPlNsZWVwLypwaHlzaW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPlNsZWVwIElu
aXRpYXRpb24gYW5kIE1haW50ZW5hbmNlIERpc29yZGVycy9kaWFnbm9zaXMvcHN5Y2hvbG9neS8q
dGhlcmFweTwva2V5d29yZD48a2V5d29yZD4qU3R1ZGVudHM8L2tleXdvcmQ+PGtleXdvcmQ+U3Vy
dmV5cyBhbmQgUXVlc3Rpb25uYWlyZXM8L2tleXdvcmQ+PGtleXdvcmQ+VGltZSBGYWN0b3JzPC9r
ZXl3b3JkPjxrZXl3b3JkPlRyZWF0bWVudCBPdXRjb21lPC9rZXl3b3JkPjxrZXl3b3JkPllvdW5n
IEFkdWx0PC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTQ8L3llYXI+PHB1Yi1k
YXRlcz48ZGF0ZT5NYXk8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xODc4LTE4ODgg
KEVsZWN0cm9uaWMpJiN4RDswMDA1LTc4OTQgKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVt
PjI0NjgwMjMyPC9hY2Nlc3Npb24tbnVtPjx3b3JrLXR5cGU+UmFuZG9taXplZCBDb250cm9sbGVk
IFRyaWFsJiN4RDtSZXNlYXJjaCBTdXBwb3J0LCBOb24tVS5TLiBHb3YmYXBvczt0PC93b3JrLXR5
cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9w
dWJtZWQvMjQ2ODAyMzI8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVz
b3VyY2UtbnVtPjEwLjEwMTYvai5iZXRoLjIwMTMuMTIuMDEwPC9lbGVjdHJvbmljLXJlc291cmNl
LW51bT48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhv
cj5Ub21mb2hyLU1hZHNlbjwvQXV0aG9yPjxZZWFyPjIwMTY8L1llYXI+PFJlY051bT4yODc8L1Jl
Y051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjI4NzwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxr
ZXkgYXBwPSJFTiIgZGItaWQ9IjVwcndlNXNhMXN6MnNwZWVmd3I1dHgwb3hkdzlzenp4cGFzciI+
Mjg3PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+
MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5Ub21mb2hyLU1hZHNl
biwgTC4gTS48L2F1dGhvcj48YXV0aG9yPkNsYXlib3JuZSwgWi4gTS48L2F1dGhvcj48YXV0aG9y
PlJvdWxlYXUsIEMuIFIuPC9hdXRob3I+PGF1dGhvcj5DYW1wYmVsbCwgVC4gUy48L2F1dGhvcj48
L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5hIERlcGFydG1lbnQgb2YgUHN5
Y2hvbG9neSAsIFVuaXZlcnNpdHkgb2YgQ2FsZ2FyeSAsIENhbGdhcnkgLCBBbGJlcnRhICwgQ2Fu
YWRhLiYjeEQ7YiBBbGJlcnRhIENoaWxkcmVuJmFwb3M7cyBIb3NwaXRhbCBSZXNlYXJjaCBJbnN0
aXR1dGUgZm9yIENoaWxkIGFuZCBNYXRlcm5hbCBIZWFsdGggLCBDYWxnYXJ5ICwgQWxiZXJ0YSAs
IENhbmFkYS4mI3hEO2MgRGVwYXJ0bWVudCBvZiBQZWRpYXRyaWNzICwgQWxiZXJ0YSBDaGlsZHJl
biZhcG9zO3MgSG9zcGl0YWwgLCBDYWxnYXJ5ICwgQWxiZXJ0YSAsIENhbmFkYS48L2F1dGgtYWRk
cmVzcz48dGl0bGVzPjx0aXRsZT5TbGVlcGluZyBmb3IgVHdvOiBBbiBPcGVuLVBpbG90IFN0dWR5
IG9mIENvZ25pdGl2ZSBCZWhhdmlvcmFsIFRoZXJhcHkgZm9yIEluc29tbmlhIGluIFByZWduYW5j
eTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5CZWhhdiBTbGVlcCBNZWQ8L3NlY29uZGFyeS10aXRs
ZT48YWx0LXRpdGxlPkJlaGF2aW9yYWwgc2xlZXAgbWVkaWNpbmU8L2FsdC10aXRsZT48L3RpdGxl
cz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5CZWhhdiBTbGVlcCBNZWQ8L2Z1bGwtdGl0bGU+PGFi
YnItMT5CZWhhdmlvcmFsIHNsZWVwIG1lZGljaW5lPC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxhbHQt
cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5CZWhhdiBTbGVlcCBNZWQ8L2Z1bGwtdGl0bGU+PGFiYnIt
MT5CZWhhdmlvcmFsIHNsZWVwIG1lZGljaW5lPC9hYmJyLTE+PC9hbHQtcGVyaW9kaWNhbD48cGFn
ZXM+MS0xNzwvcGFnZXM+PGVkaXRpb24+MjAxNi8wNC8yOTwvZWRpdGlvbj48ZGF0ZXM+PHllYXI+
MjAxNjwveWVhcj48cHViLWRhdGVzPjxkYXRlPkFwciAyODwvZGF0ZT48L3B1Yi1kYXRlcz48L2Rh
dGVzPjxpc2JuPjE1NDAtMjAxMCAoRWxlY3Ryb25pYykmI3hEOzE1NDAtMjAwMiAoTGlua2luZyk8
L2lzYm4+PGFjY2Vzc2lvbi1udW0+MjcxMjQ0MDU8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0
ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMjcxMjQ0MDU8
L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEw
ODAvMTU0MDIwMDIuMjAxNi4xMTQxNzY5PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48bGFuZ3Vh
Z2U+RW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPn==
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bcm5lZHQ8L0F1dGhvcj48WWVhcj4yMDExPC9ZZWFyPjxS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ADDIN EN.CITE.DATA (45-48, 50, 52, 54, 58, 60-62). Eight studies described efforts to ensure treatment fidelity (e.g. use of checklists, meetings between researchers, evaluation of recordings of treatment delivery) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bcm5lZHQ8L0F1dGhvcj48WWVhcj4yMDExPC9ZZWFyPjxS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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bcm5lZHQ8L0F1dGhvcj48WWVhcj4yMDExPC9ZZWFyPjxS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ADDIN EN.CITE.DATA (45, 46, 49, 54, 55, 58, 60, 62). It was common for the studies included in this review to adapt the intervention to address the links between comorbid or secondary conditions and sleep. The two studies of adults recovering from alcohol dependence adapted the intervention to include psychoeducation about the effects of alcohol use and withdrawal on sleep PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bcm5lZHQ8L0F1dGhvcj48WWVhcj4yMDA3PC9ZZWFyPjxS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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bcm5lZHQ8L0F1dGhvcj48WWVhcj4yMDA3PC9ZZWFyPjxS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ADDIN EN.CITE.DATA (45, 56). One of these studies also included cognitive restructuring of unhelpful thoughts and beliefs about relapse PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bcm5lZHQ8L0F1dGhvcj48WWVhcj4yMDExPC9ZZWFyPjxS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==
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bcm5lZHQ8L0F1dGhvcj48WWVhcj4yMDExPC9ZZWFyPjxS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==
ADDIN EN.CITE.DATA (45). A study in cancer patients provided psychoeducation about how to cope with fatigue using physical activity ADDIN EN.CITE <EndNote><Cite><Author>Quesnel</Author><Year>2003</Year><RecNum>276</RecNum><DisplayText>(62)</DisplayText><record><rec-number>276</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr">276</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Quesnel, C.</author><author>Savard, J.</author><author>Simard, S.</author><author>Ivers, H.</author><author>Morin, C. M.</author></authors></contributors><auth-address>School of Psychology and Cancer Research Centre, Universite Laval, Quebec, Quebec, Canada.</auth-address><titles><title>Efficacy of cognitive-behavioral therapy for insomnia in women treated for nonmetastatic breast cancer</title><secondary-title>J Consult Clin Psychol</secondary-title><alt-title>Journal of consulting and clinical psychology</alt-title></titles><periodical><full-title>J Consult Clin Psychol</full-title></periodical><pages>189-200</pages><volume>71</volume><number>1</number><edition>2003/02/27</edition><keywords><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Breast Neoplasms/*psychology</keyword><keyword>Cognitive Therapy/*methods</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Middle Aged</keyword><keyword>Polysomnography</keyword><keyword>Quality of Life</keyword><keyword>Sleep Initiation and Maintenance Disorders/diagnosis/*etiology/*therapy</keyword><keyword>Surveys and Questionnaires</keyword></keywords><dates><year>2003</year><pub-dates><date>Feb</date></pub-dates></dates><isbn>0022-006X (Print)
0022-006X (Linking)</isbn><accession-num>12602439</accession-num><work-type>Clinical Trial
Research Support, Non-U.S. Gov't</work-type><urls><related-urls><url>;(62). Both of the studies in fibromyalgia patients provided psychoeducation about the link between fibromyalgia, pain and sleep PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MYW1pPC9BdXRob3I+PFllYXI+MjAxNjwvWWVhcj48UmVj
TnVtPjI2NjwvUmVjTnVtPjxEaXNwbGF5VGV4dD4oNTAsIDU4KTwvRGlzcGxheVRleHQ+PHJlY29y
ZD48cmVjLW51bWJlcj4yNjY8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4i
IGRiLWlkPSI1cHJ3ZTVzYTFzejJzcGVlZndyNXR4MG94ZHc5c3p6eHBhc3IiPjI2Njwva2V5Pjwv
Zm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlw
ZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+TGFtaSwgTS4gSi48L2F1dGhvcj48YXV0
aG9yPk1hcnRpbmV6LCBNLiBQLjwvYXV0aG9yPjxhdXRob3I+U2FuY2hleiwgQS4gSS48L2F1dGhv
cj48YXV0aG9yPk1pcm8sIEUuPC9hdXRob3I+PGF1dGhvcj5EaWVuZXIsIEYuIE4uPC9hdXRob3I+
PGF1dGhvcj5QcmFkb3MsIEcuPC9hdXRob3I+PGF1dGhvcj5HdXptYW4sIE0uIEEuPC9hdXRob3I+
PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+RGVwYXJ0bWVudCBvZiBQZXJz
b25hbGl0eSwgQXNzZXNzbWVudCwgYW5kIFBzeWNob2xvZ2ljYWwgVHJlYXRtZW50LCBGYWN1bHR5
IG9mIFBzeWNob2xvZ3ksIFVuaXZlcnNpdHkgb2YgR3JhbmFkYSwgR3JhbmFkYSwgU3BhaW4uJiN4
RDtNaW5kLCBCcmFpbiBhbmQgQmVoYXZpb3IgUmVzZWFyY2ggQ2VudGVyIChDSU1DWUMpLCBVbml2
ZXJzaXR5IG9mIEdyYW5hZGEsIEdyYW5hZGEsIFNwYWluLiYjeEQ7SW50ZXJuYWwgTWVkaWNpbmUg
U2VydmljZSwgVmlyZ2VuIGRlIGxhcyBOaWV2ZXMgVW5pdmVyc2l0eSBIb3NwaXRhbCwgYW5kIFJo
ZXVtYXRvbG9neSBTZXJ2aWNlLCBWaXJnZW4gZGUgbGFzIE5pZXZlcyBVbml2ZXJzaXR5IEhvc3Bp
dGFsLCBHcmFuYWRhLCBTcGFpbi48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5HZW5kZXIg
RGlmZmVyZW5jZXMgaW4gUGF0aWVudHMgd2l0aCBGaWJyb215YWxnaWEgVW5kZXJnb2luZyBDb2du
aXRpdmUtQmVoYXZpb3JhbCBUaGVyYXB5IGZvciBJbnNvbW5pYTogUHJlbGltaW5hcnkgRGF0YTwv
dGl0bGU+PHNlY29uZGFyeS10aXRsZT5QYWluIFByYWN0PC9zZWNvbmRhcnktdGl0bGU+PGFsdC10
aXRsZT5QYWluIHByYWN0aWNlIDogdGhlIG9mZmljaWFsIGpvdXJuYWwgb2YgV29ybGQgSW5zdGl0
dXRlIG9mIFBhaW48L2FsdC10aXRsZT48L3RpdGxlcz48cGFnZXM+RTIzLTM0PC9wYWdlcz48dm9s
dW1lPjE2PC92b2x1bWU+PG51bWJlcj4yPC9udW1iZXI+PGVkaXRpb24+MjAxNi8wMi8wNDwvZWRp
dGlvbj48ZGF0ZXM+PHllYXI+MjAxNjwveWVhcj48cHViLWRhdGVzPjxkYXRlPkZlYjwvZGF0ZT48
L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE1MzMtMjUwMCAoRWxlY3Ryb25pYykmI3hEOzE1MzAt
NzA4NSAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MjY4NDExOTg8L2FjY2Vzc2lvbi1u
dW0+PHdvcmstdHlwZT5SZXNlYXJjaCBTdXBwb3J0LCBOb24tVS5TLiBHb3YmYXBvczt0PC93b3Jr
LXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdv
di9wdWJtZWQvMjY4NDExOTg8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGVsZWN0cm9uaWMt
cmVzb3VyY2UtbnVtPjEwLjExMTEvcGFwci4xMjQxMTwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+
PGxhbmd1YWdlPmVuZzwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+TWly
bzwvQXV0aG9yPjxZZWFyPjIwMTE8L1llYXI+PFJlY051bT4yNzE8L1JlY051bT48cmVjb3JkPjxy
ZWMtbnVtYmVyPjI3MTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGIt
aWQ9IjVwcndlNXNhMXN6MnNwZWVmd3I1dHgwb3hkdzlzenp4cGFzciI+MjcxPC9rZXk+PC9mb3Jl
aWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxj
b250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5NaXJvLCBFLjwvYXV0aG9yPjxhdXRob3I+THVw
aWFuZXosIEouPC9hdXRob3I+PGF1dGhvcj5NYXJ0aW5leiwgTS4gUC48L2F1dGhvcj48YXV0aG9y
PlNhbmNoZXosIEEuIEkuPC9hdXRob3I+PGF1dGhvcj5EaWF6LVBpZWRyYSwgQy48L2F1dGhvcj48
YXV0aG9yPkd1em1hbiwgTS4gQS48L2F1dGhvcj48YXV0aG9yPkJ1ZWxhLUNhc2FsLCBHLjwvYXV0
aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPlVuaXZlcnNpZGFkIGRl
IEdyYW5hZGEsIENhbXB1cyBVbml2ZXJzaXRhcmlvIGRlIGxhIENhcnR1amEsIHMvbiwgQ1AuIDE4
MDcxLCBHcmFuYWRhLCBTcGFpbi4gZW1pcm9AdWdyLmU8L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0
aXRsZT5Db2duaXRpdmUtYmVoYXZpb3JhbCB0aGVyYXB5IGZvciBpbnNvbW5pYSBpbXByb3ZlcyBh
dHRlbnRpb25hbCBmdW5jdGlvbiBpbiBmaWJyb215YWxnaWEgc3luZHJvbWU6IGEgcGlsb3QsIHJh
bmRvbWl6ZWQgY29udHJvbGxlZCB0cmlhbDwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5KIEhlYWx0
aCBQc3ljaG9sPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5Kb3VybmFsIG9mIGhlYWx0aCBw
c3ljaG9sb2d5PC9hbHQtdGl0bGU+PC90aXRsZXM+PHBhZ2VzPjc3MC04MjwvcGFnZXM+PHZvbHVt
ZT4xNjwvdm9sdW1lPjxudW1iZXI+NTwvbnVtYmVyPjxlZGl0aW9uPjIwMTEvMDIvMjU8L2VkaXRp
b24+PGtleXdvcmRzPjxrZXl3b3JkPkFjdGl2aXRpZXMgb2YgRGFpbHkgTGl2aW5nL3BzeWNob2xv
Z3k8L2tleXdvcmQ+PGtleXdvcmQ+QWR1bHQ8L2tleXdvcmQ+PGtleXdvcmQ+QXR0ZW50aW9uPC9r
ZXl3b3JkPjxrZXl3b3JkPipDb2duaXRpdmUgVGhlcmFweS9tZXRob2RzPC9rZXl3b3JkPjxrZXl3
b3JkPkV4ZWN1dGl2ZSBGdW5jdGlvbjwva2V5d29yZD48a2V5d29yZD5GZW1hbGU8L2tleXdvcmQ+
PGtleXdvcmQ+Rmlicm9teWFsZ2lhL2NvbXBsaWNhdGlvbnMvcHN5Y2hvbG9neS8qdGhlcmFweTwv
a2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+TWlkZGxlIEFnZWQ8L2tl
eXdvcmQ+PGtleXdvcmQ+TmV1cm9wc3ljaG9sb2dpY2FsIFRlc3RzPC9rZXl3b3JkPjxrZXl3b3Jk
PlBpbG90IFByb2plY3RzPC9rZXl3b3JkPjxrZXl3b3JkPlNsZWVwPC9rZXl3b3JkPjxrZXl3b3Jk
PlNsZWVwIEluaXRpYXRpb24gYW5kIE1haW50ZW5hbmNlIERpc29yZGVycy9jb21wbGljYXRpb25z
L3BzeWNob2xvZ3kvKnRoZXJhcHk8L2tleXdvcmQ+PGtleXdvcmQ+U3VydmV5cyBhbmQgUXVlc3Rp
b25uYWlyZXM8L2tleXdvcmQ+PGtleXdvcmQ+VHJlYXRtZW50IE91dGNvbWU8L2tleXdvcmQ+PC9r
ZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxMTwveWVhcj48cHViLWRhdGVzPjxkYXRlPkp1bDwvZGF0
ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE0NjEtNzI3NyAoRWxlY3Ryb25pYykmI3hEOzEz
NTktMTA1MyAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MjEzNDYwMjA8L2FjY2Vzc2lv
bi1udW0+PHdvcmstdHlwZT5SYW5kb21pemVkIENvbnRyb2xsZWQgVHJpYWwmI3hEO1Jlc2VhcmNo
IFN1cHBvcnQsIE5vbi1VLlMuIEdvdiZhcG9zO3Q8L3dvcmstdHlwZT48dXJscz48cmVsYXRlZC11
cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8yMTM0NjAyMDwvdXJs
PjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTE3Ny8x
MzU5MTA1MzEwMzkwNTQ0PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48bGFuZ3VhZ2U+ZW5nPC9s
YW5ndWFnZT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPgB=
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MYW1pPC9BdXRob3I+PFllYXI+MjAxNjwvWWVhcj48UmVj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ADDIN EN.CITE.DATA (50, 58). Description of control and comparative conditionsBoth passive and active control conditions were used. Two RCTs compared CBT-I to behavioural placebo treatment (BPT) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bcm5lZHQ8L0F1dGhvcj48WWVhcj4yMDExPC9ZZWFyPjxS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==
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bcm5lZHQ8L0F1dGhvcj48WWVhcj4yMDExPC9ZZWFyPjxS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==
ADDIN EN.CITE.DATA (45, 49). One RCT compared CBT-I to Zopiclone PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5PbXZpazwvQXV0aG9yPjxZZWFyPjIwMDg8L1llYXI+PFJl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=
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5PbXZpazwvQXV0aG9yPjxZZWFyPjIwMDg8L1llYXI+PFJl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=
ADDIN EN.CITE.DATA (51). Four studies used self-help information as a comparator PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bcm5lZHQ8L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFyPjxS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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bcm5lZHQ8L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFyPjxS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ADDIN EN.CITE.DATA (46, 48, 53, 55). One study compared CBT-I delivered in a group format to sleep hygiene delivered in a group format PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NaXJvPC9BdXRob3I+PFllYXI+MjAxMTwvWWVhcj48UmVj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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NaXJvPC9BdXRob3I+PFllYXI+MjAxMTwvWWVhcj48UmVj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ADDIN EN.CITE.DATA (50). One non-randomised controlled trial compared “sleep management training” delivered within a standard cancer rehabilitation treatment to the rehabilitation treatment alone ADDIN EN.CITE <EndNote><Cite><Author>Simeit</Author><Year>2004</Year><RecNum>279</RecNum><DisplayText>(61)</DisplayText><record><rec-number>279</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr">279</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Simeit, R.</author><author>Deck, R.</author><author>Conta-Marx, B.</author></authors></contributors><auth-address>Ropersbergklinik Ratzeburg, Ropersberg 47, 23909 Ratzeburg, Germany. info@rkrz.de</auth-address><titles><title>Sleep management training for cancer patients with insomnia</title><secondary-title>Support Care Cancer</secondary-title><alt-title>Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer</alt-title></titles><pages>176-83</pages><volume>12</volume><number>3</number><edition>2004/02/05</edition><keywords><keyword>Attitude to Health</keyword><keyword>Female</keyword><keyword>Health Care Surveys</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Neoplasms/*complications/psychology</keyword><keyword>Patient Education as Topic/*methods</keyword><keyword>Program Evaluation</keyword><keyword>Quality of Life</keyword><keyword>Relaxation Therapy/*education</keyword><keyword>Sleep Initiation and Maintenance Disorders/prevention & control/*rehabilitation</keyword><keyword>Surveys and Questionnaires</keyword></keywords><dates><year>2004</year><pub-dates><date>Mar</date></pub-dates></dates><isbn>0941-4355 (Print)
0941-4355 (Linking)</isbn><accession-num>14760542</accession-num><work-type>Clinical Trial
Controlled Clinical Trial
Research Support, Non-U.S. Gov't</work-type><urls><related-urls><url>;(61). Three RCTs compared CBT-I to no treatment PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DYXNhdWx0PC9BdXRob3I+PFllYXI+MjAxNTwvWWVhcj48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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DYXNhdWx0PC9BdXRob3I+PFllYXI+MjAxNTwvWWVhcj48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ADDIN EN.CITE.DATA (47, 52, 54).Description of subjective cognitive outcome measuresFourteen studies employed a subjective measure of cognitive functioning. Six studies used the mental fatigue subscale from the multidimensional fatigue inventory (MFI-20) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bcm5lZHQ8L0F1dGhvcj48WWVhcj4yMDA3PC9ZZWFyPjxS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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bcm5lZHQ8L0F1dGhvcj48WWVhcj4yMDA3PC9ZZWFyPjxS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ADDIN EN.CITE.DATA (45, 46, 52, 54, 56, 58-60). This subscale contains four items which assess cognitive symptoms of fatigue, such as difficulties concentrating (“When I am doing something, I can keep my thoughts on it”, “I can concentrate well”, “My thoughts easily wander” and “It takes a lot of effort to concentrate on things”) ADDIN EN.CITE <EndNote><Cite><Author>Smets</Author><Year>1995</Year><RecNum>425</RecNum><DisplayText>(65)</DisplayText><record><rec-number>425</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr">425</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Smets, E. M.</author><author>Garssen, B.</author><author>Bonke, B.</author><author>De Haes, J. C.</author></authors></contributors><auth-address>University of Amsterdam, Department of Medical Psychology, The Netherlands.</auth-address><titles><title>The Multidimensional Fatigue Inventory (MFI) psychometric qualities of an instrument to assess fatigue</title><secondary-title>J Psychosom Res</secondary-title><alt-title>Journal of psychosomatic research</alt-title></titles><periodical><full-title>J Psychosom Res</full-title><abbr-1>Journal of psychosomatic research</abbr-1></periodical><alt-periodical><full-title>J Psychosom Res</full-title><abbr-1>Journal of psychosomatic research</abbr-1></alt-periodical><pages>315-25</pages><volume>39</volume><number>3</number><edition>1995/04/01</edition><keywords><keyword>Adult</keyword><keyword>Cognition Disorders/etiology</keyword><keyword>Fatigue/complications/*diagnosis</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Motivation</keyword><keyword>Neoplasms/complications/radiotherapy</keyword><keyword>*Psychometrics</keyword><keyword>Reproducibility of Results</keyword><keyword>Surveys and Questionnaires</keyword></keywords><dates><year>1995</year><pub-dates><date>Apr</date></pub-dates></dates><isbn>0022-3999 (Print)
0022-3999 (Linking)</isbn><accession-num>7636775</accession-num><work-type>Comparative Study
Research Support, Non-U.S. Gov't</work-type><urls><related-urls><url>;(65). Two studies used the mental fatigue subscale of the multidimensional fatigue symptom inventory – short form (MFSI-SF) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5SaXR0ZXJiYW5kPC9BdXRob3I+PFllYXI+MjAxMjwvWWVh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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5SaXR0ZXJiYW5kPC9BdXRob3I+PFllYXI+MjAxMjwvWWVh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ADDIN EN.CITE.DATA (52, 60). This subscale contains six items (“I have trouble remembering things”, “I am confused”, “I have trouble paying attention”, “I am unable to concentrate”, “I make more mistakes than usual” and “I am forgetful”). Four studies used the cognitive subscale from the European organisation for research and treatment of cancer QLQ-C30, which is an instrument that evaluates quality of life in cancer patients PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DYXNhdWx0PC9BdXRob3I+PFllYXI+MjAxNTwvWWVhcj48
UmVjTnVtPjI1NTwvUmVjTnVtPjxEaXNwbGF5VGV4dD4oNDcsIDU3LCA2MSwgNjIpPC9EaXNwbGF5
VGV4dD48cmVjb3JkPjxyZWMtbnVtYmVyPjI1NTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxr
ZXkgYXBwPSJFTiIgZGItaWQ9IjVwcndlNXNhMXN6MnNwZWVmd3I1dHgwb3hkdzlzenp4cGFzciI+
MjU1PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+
MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5DYXNhdWx0LCBMLjwv
YXV0aG9yPjxhdXRob3I+U2F2YXJkLCBKLjwvYXV0aG9yPjxhdXRob3I+SXZlcnMsIEguPC9hdXRo
b3I+PGF1dGhvcj5TYXZhcmQsIE0uIEguPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3Jz
PjxhdXRoLWFkZHJlc3M+U2Nob29sIG9mIFBzeWNob2xvZ3ksIFVuaXZlcnNpdGUgTGF2YWwsIFF1
ZWJlYywgUXVlYmVjLCBHMVYgMEE2LCBDYW5hZGE7IENlbnRyZSBkZSByZWNoZXJjaGUgZHUgQ0hV
IGRlIFF1ZWJlYyBhbmQgQ2VudHJlIGRlIHJlY2hlcmNoZSBzdXIgbGUgY2FuY2VyLCBVbml2ZXJz
aXRlIExhdmFsLCAxMSBDb3RlIGR1IFBhbGFpcywgUXVlYmVjLCBHMVIgMko2LCBDYW5hZGE7IENl
bnRyZSBob3NwaXRhbGllciB1bml2ZXJzaXRhaXJlIChDSFUpIGRlIFF1ZWJlYywgMTEsIENvdGUg
ZHUgUGFsYWlzLCBRdWViZWMsIFF1ZWJlYywgRzFSIDJKNiwgQ2FuYWRhLiYjeEQ7U2Nob29sIG9m
IFBzeWNob2xvZ3ksIFVuaXZlcnNpdGUgTGF2YWwsIFF1ZWJlYywgUXVlYmVjLCBHMVYgMEE2LCBD
YW5hZGE7IENlbnRyZSBkZSByZWNoZXJjaGUgZHUgQ0hVIGRlIFF1ZWJlYyBhbmQgQ2VudHJlIGRl
IHJlY2hlcmNoZSBzdXIgbGUgY2FuY2VyLCBVbml2ZXJzaXRlIExhdmFsLCAxMSBDb3RlIGR1IFBh
bGFpcywgUXVlYmVjLCBHMVIgMko2LCBDYW5hZGEuIEVsZWN0cm9uaWMgYWRkcmVzczogam9zZWUu
c2F2YXJkQHBzeS51bGF2YWwuY2EuJiN4RDtTY2hvb2wgb2YgUHN5Y2hvbG9neSwgVW5pdmVyc2l0
ZSBMYXZhbCwgUXVlYmVjLCBRdWViZWMsIEcxViAwQTYsIENhbmFkYTsgQ2VudHJlIGRlIHJlY2hl
cmNoZSBkdSBDSFUgZGUgUXVlYmVjIGFuZCBDZW50cmUgZGUgcmVjaGVyY2hlIHN1ciBsZSBjYW5j
ZXIsIFVuaXZlcnNpdGUgTGF2YWwsIDExIENvdGUgZHUgUGFsYWlzLCBRdWViZWMsIEcxUiAySjYs
IENhbmFkYS4mI3hEO0NlbnRyZSBkZSByZWNoZXJjaGUgZHUgQ0hVIGRlIFF1ZWJlYyBhbmQgQ2Vu
dHJlIGRlIHJlY2hlcmNoZSBzdXIgbGUgY2FuY2VyLCBVbml2ZXJzaXRlIExhdmFsLCAxMSBDb3Rl
IGR1IFBhbGFpcywgUXVlYmVjLCBHMVIgMko2LCBDYW5hZGEuPC9hdXRoLWFkZHJlc3M+PHRpdGxl
cz48dGl0bGU+QSByYW5kb21pemVkLWNvbnRyb2xsZWQgdHJpYWwgb2YgYW4gZWFybHkgbWluaW1h
bCBjb2duaXRpdmUtYmVoYXZpb3VyYWwgdGhlcmFweSBmb3IgaW5zb21uaWEgY29tb3JiaWQgd2l0
aCBjYW5jZXI8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+QmVoYXYgUmVzIFRoZXI8L3NlY29uZGFy
eS10aXRsZT48YWx0LXRpdGxlPkJlaGF2aW91ciByZXNlYXJjaCBhbmQgdGhlcmFweTwvYWx0LXRp
dGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkJlaGF2IFJlcyBUaGVyPC9mdWxs
LXRpdGxlPjxhYmJyLTE+QmVoYXZpb3VyIHJlc2VhcmNoIGFuZCB0aGVyYXB5PC9hYmJyLTE+PC9w
ZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5CZWhhdiBSZXMgVGhlcjwvZnVs
bC10aXRsZT48YWJici0xPkJlaGF2aW91ciByZXNlYXJjaCBhbmQgdGhlcmFweTwvYWJici0xPjwv
YWx0LXBlcmlvZGljYWw+PHBhZ2VzPjQ1LTU0PC9wYWdlcz48dm9sdW1lPjY3PC92b2x1bWU+PGVk
aXRpb24+MjAxNS8wMy8xMDwvZWRpdGlvbj48ZGF0ZXM+PHllYXI+MjAxNTwveWVhcj48cHViLWRh
dGVzPjxkYXRlPkFwcjwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE4NzMtNjIyWCAo
RWxlY3Ryb25pYykmI3hEOzAwMDUtNzk2NyAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+
MjU3NDY3Nzc8L2FjY2Vzc2lvbi1udW0+PHdvcmstdHlwZT5SZXNlYXJjaCBTdXBwb3J0LCBOb24t
VS5TLiBHb3YmYXBvczt0PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6
Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMjU3NDY3Nzc8L3VybD48L3JlbGF0ZWQtdXJs
cz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEwMTYvai5icmF0LjIwMTUuMDIu
MDAzPC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3Jl
Y29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5EYXZpZHNvbjwvQXV0aG9yPjxZZWFyPjIwMDE8L1ll
YXI+PFJlY051bT4yNTg8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjI1ODwvcmVjLW51bWJl
cj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9IjVwcndlNXNhMXN6MnNwZWVmd3I1
dHgwb3hkdzlzenp4cGFzciI+MjU4PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9
IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1
dGhvcj5EYXZpZHNvbiwgSi4gUi48L2F1dGhvcj48YXV0aG9yPldhaXNiZXJnLCBKLiBMLjwvYXV0
aG9yPjxhdXRob3I+QnJ1bmRhZ2UsIE0uIEQuPC9hdXRob3I+PGF1dGhvcj5NYWNMZWFuLCBBLiBX
LjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkRlcGFydG1l
bnQgb2YgUHN5Y2hvbG9neSwgUXVlZW4mYXBvcztzIFVuaXZlcnNpdHksIEtpbmdzdG9uLCBPbnRh
cmlvLCBDYW5hZGEuIGRhdmlkc25qQHBvc3QucXVlZW5zdS5jYTwvYXV0aC1hZGRyZXNzPjx0aXRs
ZXM+PHRpdGxlPk5vbnBoYXJtYWNvbG9naWMgZ3JvdXAgdHJlYXRtZW50IG9mIGluc29tbmlhOiBh
IHByZWxpbWluYXJ5IHN0dWR5IHdpdGggY2FuY2VyIHN1cnZpdm9yczwvdGl0bGU+PHNlY29uZGFy
eS10aXRsZT5Qc3ljaG9vbmNvbG9neTwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+UHN5Y2hv
LW9uY29sb2d5PC9hbHQtdGl0bGU+PC90aXRsZXM+PHBhZ2VzPjM4OS05NzwvcGFnZXM+PHZvbHVt
ZT4xMDwvdm9sdW1lPjxudW1iZXI+NTwvbnVtYmVyPjxlZGl0aW9uPjIwMDEvMDkvMDY8L2VkaXRp
b24+PGtleXdvcmRzPjxrZXl3b3JkPkF0dGl0dWRlIHRvIEhlYWx0aDwva2V5d29yZD48a2V5d29y
ZD5Db2duaXRpdmUgVGhlcmFweS8qbWV0aG9kczwva2V5d29yZD48a2V5d29yZD5GZW1hbGU8L2tl
eXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPkxvbmdpdHVkaW5hbCBTdHVk
aWVzPC9rZXl3b3JkPjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+TWlkZGxlIEFnZWQ8
L2tleXdvcmQ+PGtleXdvcmQ+TmVvcGxhc21zLypjb21wbGljYXRpb25zL3BzeWNob2xvZ3kvdGhl
cmFweTwva2V5d29yZD48a2V5d29yZD5QYXRpZW50IEVkdWNhdGlvbiBhcyBUb3BpYy8qbWV0aG9k
czwva2V5d29yZD48a2V5d29yZD5Qcm9ncmFtIEV2YWx1YXRpb248L2tleXdvcmQ+PGtleXdvcmQ+
KlJlbGF4YXRpb24gVGhlcmFweTwva2V5d29yZD48a2V5d29yZD5TZXZlcml0eSBvZiBJbGxuZXNz
IEluZGV4PC9rZXl3b3JkPjxrZXl3b3JkPlNsZWVwIEluaXRpYXRpb24gYW5kIE1haW50ZW5hbmNl
IERpc29yZGVycy8qZXRpb2xvZ3kvcHN5Y2hvbG9neS8qdGhlcmFweTwva2V5d29yZD48a2V5d29y
ZD4qU3Vydml2b3JzL3BzeWNob2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+VGltZSBGYWN0b3JzPC9r
ZXl3b3JkPjxrZXl3b3JkPlRyZWF0bWVudCBPdXRjb21lPC9rZXl3b3JkPjwva2V5d29yZHM+PGRh
dGVzPjx5ZWFyPjIwMDE8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5TZXAtT2N0PC9kYXRlPjwvcHVi
LWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTA1Ny05MjQ5IChQcmludCkmI3hEOzEwNTctOTI0OSAoTGlu
a2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MTE1MzY0MTc8L2FjY2Vzc2lvbi1udW0+PHdvcmst
dHlwZT5DbGluaWNhbCBUcmlhbCYjeEQ7Q29udHJvbGxlZCBDbGluaWNhbCBUcmlhbCYjeEQ7UmVz
ZWFyY2ggU3VwcG9ydCwgTm9uLVUuUy4gR292JmFwb3M7dDwvd29yay10eXBlPjx1cmxzPjxyZWxh
dGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzExNTM2NDE3
PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVj
b3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPlF1ZXNuZWw8L0F1dGhvcj48WWVhcj4yMDAzPC9ZZWFy
PjxSZWNOdW0+Mjc2PC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJlcj4yNzY8L3JlYy1udW1iZXI+
PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSI1cHJ3ZTVzYTFzejJzcGVlZndyNXR4
MG94ZHc5c3p6eHBhc3IiPjI3Njwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJK
b3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRo
b3I+UXVlc25lbCwgQy48L2F1dGhvcj48YXV0aG9yPlNhdmFyZCwgSi48L2F1dGhvcj48YXV0aG9y
PlNpbWFyZCwgUy48L2F1dGhvcj48YXV0aG9yPkl2ZXJzLCBILjwvYXV0aG9yPjxhdXRob3I+TW9y
aW4sIEMuIE0uPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+
U2Nob29sIG9mIFBzeWNob2xvZ3kgYW5kIENhbmNlciBSZXNlYXJjaCBDZW50cmUsIFVuaXZlcnNp
dGUgTGF2YWwsIFF1ZWJlYywgUXVlYmVjLCBDYW5hZGEuPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48
dGl0bGU+RWZmaWNhY3kgb2YgY29nbml0aXZlLWJlaGF2aW9yYWwgdGhlcmFweSBmb3IgaW5zb21u
aWEgaW4gd29tZW4gdHJlYXRlZCBmb3Igbm9ubWV0YXN0YXRpYyBicmVhc3QgY2FuY2VyPC90aXRs
ZT48c2Vjb25kYXJ5LXRpdGxlPkogQ29uc3VsdCBDbGluIFBzeWNob2w8L3NlY29uZGFyeS10aXRs
ZT48YWx0LXRpdGxlPkpvdXJuYWwgb2YgY29uc3VsdGluZyBhbmQgY2xpbmljYWwgcHN5Y2hvbG9n
eTwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkogQ29uc3VsdCBD
bGluIFBzeWNob2w8L2Z1bGwtdGl0bGU+PC9wZXJpb2RpY2FsPjxwYWdlcz4xODktMjAwPC9wYWdl
cz48dm9sdW1lPjcxPC92b2x1bWU+PG51bWJlcj4xPC9udW1iZXI+PGVkaXRpb24+MjAwMy8wMi8y
NzwvZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QWR1bHQ8L2tleXdvcmQ+PGtleXdvcmQ+QWdl
ZDwva2V5d29yZD48a2V5d29yZD5CcmVhc3QgTmVvcGxhc21zLypwc3ljaG9sb2d5PC9rZXl3b3Jk
PjxrZXl3b3JkPkNvZ25pdGl2ZSBUaGVyYXB5LyptZXRob2RzPC9rZXl3b3JkPjxrZXl3b3JkPkZl
bWFsZTwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+TWlkZGxlIEFn
ZWQ8L2tleXdvcmQ+PGtleXdvcmQ+UG9seXNvbW5vZ3JhcGh5PC9rZXl3b3JkPjxrZXl3b3JkPlF1
YWxpdHkgb2YgTGlmZTwva2V5d29yZD48a2V5d29yZD5TbGVlcCBJbml0aWF0aW9uIGFuZCBNYWlu
dGVuYW5jZSBEaXNvcmRlcnMvZGlhZ25vc2lzLypldGlvbG9neS8qdGhlcmFweTwva2V5d29yZD48
a2V5d29yZD5TdXJ2ZXlzIGFuZCBRdWVzdGlvbm5haXJlczwva2V5d29yZD48L2tleXdvcmRzPjxk
YXRlcz48eWVhcj4yMDAzPC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+RmViPC9kYXRlPjwvcHViLWRh
dGVzPjwvZGF0ZXM+PGlzYm4+MDAyMi0wMDZYIChQcmludCkmI3hEOzAwMjItMDA2WCAoTGlua2lu
Zyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MTI2MDI0Mzk8L2FjY2Vzc2lvbi1udW0+PHdvcmstdHlw
ZT5DbGluaWNhbCBUcmlhbCYjeEQ7UmVzZWFyY2ggU3VwcG9ydCwgTm9uLVUuUy4gR292JmFwb3M7
dDwvd29yay10eXBlPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxt
Lm5paC5nb3YvcHVibWVkLzEyNjAyNDM5PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxsYW5n
dWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPlNpbWVpdDwv
QXV0aG9yPjxZZWFyPjIwMDQ8L1llYXI+PFJlY051bT4yNzk8L1JlY051bT48cmVjb3JkPjxyZWMt
bnVtYmVyPjI3OTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9
IjVwcndlNXNhMXN6MnNwZWVmd3I1dHgwb3hkdzlzenp4cGFzciI+Mjc5PC9rZXk+PC9mb3JlaWdu
LWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250
cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5TaW1laXQsIFIuPC9hdXRob3I+PGF1dGhvcj5EZWNr
LCBSLjwvYXV0aG9yPjxhdXRob3I+Q29udGEtTWFyeCwgQi48L2F1dGhvcj48L2F1dGhvcnM+PC9j
b250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5Sb3BlcnNiZXJna2xpbmlrIFJhdHplYnVyZywgUm9w
ZXJzYmVyZyA0NywgMjM5MDkgUmF0emVidXJnLCBHZXJtYW55LiBpbmZvQHJrcnouZGU8L2F1dGgt
YWRkcmVzcz48dGl0bGVzPjx0aXRsZT5TbGVlcCBtYW5hZ2VtZW50IHRyYWluaW5nIGZvciBjYW5j
ZXIgcGF0aWVudHMgd2l0aCBpbnNvbW5pYTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5TdXBwb3J0
IENhcmUgQ2FuY2VyPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5TdXBwb3J0aXZlIGNhcmUg
aW4gY2FuY2VyIDogb2ZmaWNpYWwgam91cm5hbCBvZiB0aGUgTXVsdGluYXRpb25hbCBBc3NvY2lh
dGlvbiBvZiBTdXBwb3J0aXZlIENhcmUgaW4gQ2FuY2VyPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBh
Z2VzPjE3Ni04MzwvcGFnZXM+PHZvbHVtZT4xMjwvdm9sdW1lPjxudW1iZXI+MzwvbnVtYmVyPjxl
ZGl0aW9uPjIwMDQvMDIvMDU8L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkF0dGl0dWRlIHRv
IEhlYWx0aDwva2V5d29yZD48a2V5d29yZD5GZW1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+SGVhbHRo
IENhcmUgU3VydmV5czwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+
TWFsZTwva2V5d29yZD48a2V5d29yZD5NaWRkbGUgQWdlZDwva2V5d29yZD48a2V5d29yZD5OZW9w
bGFzbXMvKmNvbXBsaWNhdGlvbnMvcHN5Y2hvbG9neTwva2V5d29yZD48a2V5d29yZD5QYXRpZW50
IEVkdWNhdGlvbiBhcyBUb3BpYy8qbWV0aG9kczwva2V5d29yZD48a2V5d29yZD5Qcm9ncmFtIEV2
YWx1YXRpb248L2tleXdvcmQ+PGtleXdvcmQ+UXVhbGl0eSBvZiBMaWZlPC9rZXl3b3JkPjxrZXl3
b3JkPlJlbGF4YXRpb24gVGhlcmFweS8qZWR1Y2F0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPlNsZWVw
IEluaXRpYXRpb24gYW5kIE1haW50ZW5hbmNlIERpc29yZGVycy9wcmV2ZW50aW9uICZhbXA7IGNv
bnRyb2wvKnJlaGFiaWxpdGF0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPlN1cnZleXMgYW5kIFF1ZXN0
aW9ubmFpcmVzPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMDQ8L3llYXI+PHB1
Yi1kYXRlcz48ZGF0ZT5NYXI8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4wOTQxLTQz
NTUgKFByaW50KSYjeEQ7MDk0MS00MzU1IChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4x
NDc2MDU0MjwvYWNjZXNzaW9uLW51bT48d29yay10eXBlPkNsaW5pY2FsIFRyaWFsJiN4RDtDb250
cm9sbGVkIENsaW5pY2FsIFRyaWFsJiN4RDtSZXNlYXJjaCBTdXBwb3J0LCBOb24tVS5TLiBHb3Ym
YXBvczt0PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cubmNi
aS5ubG0ubmloLmdvdi9wdWJtZWQvMTQ3NjA1NDI8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+
PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEwMDcvczAwNTIwLTAwNC0wNTk0LTU8L2VsZWN0
cm9uaWMtcmVzb3VyY2UtbnVtPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0
ZT48L0VuZE5vdGU+AG==
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DYXNhdWx0PC9BdXRob3I+PFllYXI+MjAxNTwvWWVhcj48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ADDIN EN.CITE.DATA (47, 57, 61, 62). This subscale contains two items probing concentration and memory (“Have you had difficulties concentrating on things, like reading a newspaper or watching television” and “Have you had difficulty remembering things?”) ADDIN EN.CITE <EndNote><Cite><Author>Aaronson</Author><Year>1993</Year><RecNum>426</RecNum><DisplayText>(66)</DisplayText><record><rec-number>426</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr">426</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Aaronson, N. K.</author><author>Ahmedzai, S.</author><author>Bergman, B.</author><author>Bullinger, M.</author><author>Cull, A.</author><author>Duez, N. J.</author><author>Filiberti, A.</author><author>Flechtner, H.</author><author>Fleishman, S. B.</author><author>de Haes, J. C.</author><author>et al.,</author></authors></contributors><titles><title>The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology</title><secondary-title>J Natl Cancer Inst</secondary-title><alt-title>Journal of the National Cancer Institute</alt-title></titles><pages>365-76</pages><volume>85</volume><number>5</number><edition>1993/03/03</edition><keywords><keyword>Activities of Daily Living</keyword><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Aged, 80 and over</keyword><keyword>Clinical Trials as Topic</keyword><keyword>Female</keyword><keyword>Health Status</keyword><keyword>Humans</keyword><keyword>Lung Neoplasms/*therapy</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>*Quality of Life</keyword><keyword>Reproducibility of Results</keyword><keyword>*Surveys and Questionnaires</keyword></keywords><dates><year>1993</year><pub-dates><date>Mar 3</date></pub-dates></dates><isbn>0027-8874 (Print)
0027-8874 (Linking)</isbn><accession-num>8433390</accession-num><work-type>Multicenter Study</work-type><urls><related-urls><url>;(66). One study used the attentional function index (AFI) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NYXR0aGV3czwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NYXR0aGV3czwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+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ADDIN EN.CITE.DATA (49), which is a measure of perceived effectiveness in common activities requiring attention and working memory. The total score on this instrument is thought to provide an overall index of attentional functioning ADDIN EN.CITE <EndNote><Cite><Author>Cimprich</Author><Year>1993</Year><RecNum>427</RecNum><DisplayText>(67)</DisplayText><record><rec-number>427</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr">427</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Cimprich, B.</author></authors></contributors><auth-address>University of Wisconsin, Madison 53792.</auth-address><titles><title>Development of an intervention to restore attention in cancer patients</title><secondary-title>Cancer Nurs</secondary-title><alt-title>Cancer nursing</alt-title></titles><periodical><full-title>Cancer Nurs</full-title><abbr-1>Cancer nursing</abbr-1></periodical><alt-periodical><full-title>Cancer Nurs</full-title><abbr-1>Cancer nursing</abbr-1></alt-periodical><pages>83-92</pages><volume>16</volume><number>2</number><edition>1993/04/01</edition><keywords><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Aged, 80 and over</keyword><keyword>*Attention/physiology</keyword><keyword>Breast Neoplasms/nursing/*psychology/surgery</keyword><keyword>Chemotherapy, Adjuvant</keyword><keyword>Depression/psychology</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Leisure Activities</keyword><keyword>Mastectomy</keyword><keyword>Mastectomy, Segmental</keyword><keyword>Middle Aged</keyword><keyword>Psychological Tests</keyword><keyword>Self-Assessment</keyword><keyword>Tamoxifen/therapeutic use</keyword><keyword>Time Factors</keyword></keywords><dates><year>1993</year><pub-dates><date>Apr</date></pub-dates></dates><isbn>0162-220X (Print)
0162-220X (Linking)</isbn><accession-num>8477404</accession-num><work-type>Clinical Trial
Randomized Controlled Trial
Research Support, U.S. Gov't, P.H.S.</work-type><urls><related-urls><url>;(67). One study used a Likert scale measure of difficulties with concentration PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5KYW5zc29uPC9BdXRob3I+PFllYXI+MjAwNTwvWWVhcj48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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5KYW5zc29uPC9BdXRob3I+PFllYXI+MjAwNTwvWWVhcj48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ADDIN EN.CITE.DATA (48).Description of objective cognitive outcome measuresFour studies employed an objective measure of cognitive functioning. The attentional network test - interactions task (ANT-I) was utilised by Miro et al PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NaXJvPC9BdXRob3I+PFllYXI+MjAxMTwvWWVhcj48UmVj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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NaXJvPC9BdXRob3I+PFllYXI+MjAxMTwvWWVhcj48UmVj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ADDIN EN.CITE.DATA (50). This is a computerised cognitive test which assesses three aspects of attentional functioning (orienting, alerting and executive functioning), as well as the interactions between these three networks ADDIN EN.CITE <EndNote><Cite><Author>Fan</Author><Year>2002</Year><RecNum>429</RecNum><DisplayText>(68)</DisplayText><record><rec-number>429</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr">429</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Fan, J.</author><author>McCandliss, B. D.</author><author>Sommer, T.</author><author>Raz, A.</author><author>Posner, M. I.</author></authors></contributors><auth-address>The Sackler Institute for Developmental Psychobiology, Department of Psychiatry, Weill Medical College of Cornell University, 1300 York Avenue, Box 140, New York, NY 10002, USA. jif2004@med.cornell.edu</auth-address><titles><title>Testing the efficiency and independence of attentional networks</title><secondary-title>J Cogn Neurosci</secondary-title><alt-title>Journal of cognitive neuroscience</alt-title></titles><pages>340-7</pages><volume>14</volume><number>3</number><edition>2002/04/24</edition><keywords><keyword>Adult</keyword><keyword>Analysis of Variance</keyword><keyword>Attention/*physiology</keyword><keyword>Cognition Disorders/*diagnosis/physiopathology</keyword><keyword>*Diagnosis, Computer-Assisted</keyword><keyword>Female</keyword><keyword>Head Injuries, Closed/*diagnosis/physiopathology</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Neuropsychological Tests</keyword><keyword>Orientation/physiology</keyword><keyword>Psychomotor Performance</keyword><keyword>Reproducibility of Results</keyword></keywords><dates><year>2002</year><pub-dates><date>Apr 1</date></pub-dates></dates><isbn>0898-929X (Print)
0898-929X (Linking)</isbn><accession-num>11970796</accession-num><work-type>Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.</work-type><urls><related-urls><url>;(68). One study PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5PbXZpazwvQXV0aG9yPjxZZWFyPjIwMDg8L1llYXI+PFJl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=
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5PbXZpazwvQXV0aG9yPjxZZWFyPjIwMDg8L1llYXI+PFJl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=
ADDIN EN.CITE.DATA (51) used the vigil test which is a computerised test of sustained attention ADDIN EN.CITE <EndNote><Cite><Author>Schuhfried</Author><Year>2004</Year><RecNum>431</RecNum><DisplayText>(69)</DisplayText><record><rec-number>431</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr">431</key></foreign-keys><ref-type name="Computer Program">9</ref-type><contributors><authors><author>Schuhfried, G.</author></authors></contributors><titles><title>Vigilance</title></titles><number>Release 25.0</number><dates><year>2004</year></dates><pub-location>M?dling, Austria</pub-location><urls></urls></record></Cite></EndNote>(69). Two of the included studies used neuropsychological tests to assess cognitive performance PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TdW48L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFyPjxSZWNO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 EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TdW48L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFyPjxSZWNO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 EN.CITE.DATA (53, 55). The study by Wilckens et al. ADDIN EN.CITE <EndNote><Cite><Author>Wilckens</Author><Year>2016</Year><RecNum>288</RecNum><DisplayText>(55)</DisplayText><record><rec-number>288</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr">288</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Wilckens, K. A.</author><author>Hall, M. H.</author><author>Nebes, R. D.</author><author>Monk, T. H.</author><author>Buysse, D. J.</author></authors></contributors><auth-address>a Department of Psychiatry , University of Pittsburgh School of Medicine , USA.</auth-address><titles><title>Changes in Cognitive Performance Are Associated with Changes in Sleep in Older Adults With Insomnia</title><secondary-title>Behav Sleep Med</secondary-title><alt-title>Behavioral sleep medicine</alt-title></titles><periodical><full-title>Behav Sleep Med</full-title><abbr-1>Behavioral sleep medicine</abbr-1></periodical><alt-periodical><full-title>Behav Sleep Med</full-title><abbr-1>Behavioral sleep medicine</abbr-1></alt-periodical><pages>295-310</pages><volume>14</volume><number>3</number><edition>2015/09/01</edition><dates><year>2016</year><pub-dates><date>May-Jun</date></pub-dates></dates><isbn>1540-2010 (Electronic)
1540-2002 (Linking)</isbn><accession-num>26322904</accession-num><urls><related-urls><url>;(55) administered the logical memory test to assess episodic memory ADDIN EN.CITE <EndNote><Cite><Author>Wechsler</Author><Year>1997b</Year><RecNum>433</RecNum><DisplayText>(70)</DisplayText><record><rec-number>433</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr">433</key></foreign-keys><ref-type name="Book">6</ref-type><contributors><authors><author>Wechsler, D.</author></authors></contributors><titles><title>Wechsler Memory Scale (WMS-III)</title></titles><dates><year>1997b</year></dates><pub-location>San Antonio, TX</pub-location><publisher>Psychological Corporation</publisher><urls></urls></record></Cite></EndNote>(70), the test of nonverbal intelligence III (TONI) to assess abstract reasoning and figural problem solving ADDIN EN.CITE <EndNote><Cite><Author>Brown</Author><Year>1997</Year><RecNum>435</RecNum><DisplayText>(71)</DisplayText><record><rec-number>435</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr">435</key></foreign-keys><ref-type name="Book">6</ref-type><contributors><authors><author>Brown, R.</author><author>Sheronbenou, R.J.</author><author>Johnsen, S.K.</author></authors></contributors><titles><title>Test of nonverbal intelligence</title></titles><volume>Third Edition (TONI-3)</volume><dates><year>1997</year></dates><pub-location>San Antonio, TX</pub-location><publisher>Pearson</publisher><urls></urls></record></Cite></EndNote>(71) and the letter-number sequencing test to assess working memory ADDIN EN.CITE <EndNote><Cite><Author>Wechsler</Author><Year>1997a</Year><RecNum>436</RecNum><DisplayText>(72)</DisplayText><record><rec-number>436</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr">436</key></foreign-keys><ref-type name="Book">6</ref-type><contributors><authors><author>Wechsler, D.</author></authors></contributors><titles><title>Wechsler Adult Intelligence Scale (WAIS): Administration and scoring manual</title></titles><volume>3rd edition</volume><dates><year>1997a</year></dates><pub-location>San Antonio, TX</pub-location><publisher>Psychological Corporation</publisher><urls></urls></record></Cite></EndNote>(72). The study by Sun et al. ADDIN EN.CITE <EndNote><Cite><Author>Sun</Author><Year>2013</Year><RecNum>280</RecNum><DisplayText>(53)</DisplayText><record><rec-number>280</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr">280</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Sun, J.</author><author>Kang, J.</author><author>Wang, P.</author><author>Zeng, H.</author></authors></contributors><auth-address>School of Nursing, Central South University, Changsha, Hunan Province, China.</auth-address><titles><title>Self-relaxation training can improve sleep quality and cognitive functions in the older: a one-year randomised controlled trial</title><secondary-title>J Clin Nurs</secondary-title><alt-title>Journal of clinical nursing</alt-title></titles><pages>1270-80</pages><volume>22</volume><number>9-10</number><edition>2013/04/12</edition><keywords><keyword>Adolescent</keyword><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Aged, 80 and over</keyword><keyword>Analysis of Variance</keyword><keyword>Child</keyword><keyword>*Cognition</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Patient Education as Topic/*methods</keyword><keyword>*Relaxation Therapy</keyword><keyword>*Self Care</keyword><keyword>*Sleep</keyword><keyword>Surveys and Questionnaires</keyword><keyword>Young Adult</keyword></keywords><dates><year>2013</year><pub-dates><date>May</date></pub-dates></dates><isbn>1365-2702 (Electronic)
0962-1067 (Linking)</isbn><accession-num>23574290</accession-num><work-type>Randomized Controlled Trial
Research Support, Non-U.S. Gov't</work-type><urls><related-urls><url>;(53) administered the mini mental state examination (MMSE) ADDIN EN.CITE <EndNote><Cite><Author>Folstein</Author><Year>1975</Year><RecNum>448</RecNum><DisplayText>(73)</DisplayText><record><rec-number>448</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr">448</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Folstein, M. F.</author><author>Folstein, S. E.</author><author>McHugh, P. R.</author></authors></contributors><titles><title>"Mini-mental state". A practical method for grading the cognitive state of patients for the clinician</title><secondary-title>J Psychiatr Res</secondary-title><alt-title>Journal of psychiatric research</alt-title></titles><pages>189-98</pages><volume>12</volume><number>3</number><edition>1975/11/01</edition><keywords><keyword>Adult</keyword><keyword>Affective Symptoms/diagnosis</keyword><keyword>Aged</keyword><keyword>Bipolar Disorder/diagnosis</keyword><keyword>*Cognition</keyword><keyword>Cognition Disorders/etiology</keyword><keyword>Craniocerebral Trauma/complications</keyword><keyword>Dementia/diagnosis</keyword><keyword>Depression/diagnosis</keyword><keyword>Diagnosis, Differential</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Mental Disorders/*diagnosis</keyword><keyword>*Mental Status Schedule</keyword><keyword>Metabolic Diseases/complications</keyword><keyword>Middle Aged</keyword><keyword>Neurotic Disorders/diagnosis</keyword><keyword>*Psychiatric Status Rating Scales</keyword><keyword>Schizophrenia/diagnosis</keyword><keyword>Substance-Related Disorders/complications</keyword><keyword>Time Factors</keyword></keywords><dates><year>1975</year><pub-dates><date>Nov</date></pub-dates></dates><isbn>0022-3956 (Print)
0022-3956 (Linking)</isbn><accession-num>1202204</accession-num><urls><related-urls><url>;(73) to assess global cognitive functioning and the Wechsler memory scale (WMS-CR) ADDIN EN.CITE <EndNote><Cite><Author>Gong</Author><Year>1989</Year><RecNum>469</RecNum><DisplayText>(74)</DisplayText><record><rec-number>469</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr">469</key></foreign-keys><ref-type name="Book">6</ref-type><contributors><authors><author>Gong, Y.X.</author></authors></contributors><titles><title>Handbook of Wechsler Memory Scale-Revised</title></titles><dates><year>1989</year></dates><pub-location>Changsha</pub-location><publisher>Hunan Medical College</publisher><urls></urls></record></Cite></EndNote>(74) to examine memory function. Effect sizes for cognitive outcomesThe SMD could not be calculated for five studies due to lack of a control or comparator group PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bcm5lZHQ8L0F1dGhvcj48WWVhcj4yMDA3PC9ZZWFyPjxS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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bcm5lZHQ8L0F1dGhvcj48WWVhcj4yMDA3PC9ZZWFyPjxS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ADDIN EN.CITE.DATA (56-60). For one study, SMD at post-treatment and follow-up was not calculated due to non-random assignment to groups ADDIN EN.CITE <EndNote><Cite><Author>Simeit</Author><Year>2004</Year><RecNum>279</RecNum><DisplayText>(61)</DisplayText><record><rec-number>279</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr">279</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Simeit, R.</author><author>Deck, R.</author><author>Conta-Marx, B.</author></authors></contributors><auth-address>Ropersbergklinik Ratzeburg, Ropersberg 47, 23909 Ratzeburg, Germany. info@rkrz.de</auth-address><titles><title>Sleep management training for cancer patients with insomnia</title><secondary-title>Support Care Cancer</secondary-title><alt-title>Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer</alt-title></titles><pages>176-83</pages><volume>12</volume><number>3</number><edition>2004/02/05</edition><keywords><keyword>Attitude to Health</keyword><keyword>Female</keyword><keyword>Health Care Surveys</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Neoplasms/*complications/psychology</keyword><keyword>Patient Education as Topic/*methods</keyword><keyword>Program Evaluation</keyword><keyword>Quality of Life</keyword><keyword>Relaxation Therapy/*education</keyword><keyword>Sleep Initiation and Maintenance Disorders/prevention & control/*rehabilitation</keyword><keyword>Surveys and Questionnaires</keyword></keywords><dates><year>2004</year><pub-dates><date>Mar</date></pub-dates></dates><isbn>0941-4355 (Print)
0941-4355 (Linking)</isbn><accession-num>14760542</accession-num><work-type>Clinical Trial
Controlled Clinical Trial
Research Support, Non-U.S. Gov't</work-type><urls><related-urls><url>;(61). Two studies reported follow-up data only PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5KYW5zc29uPC9BdXRob3I+PFllYXI+MjAwNTwvWWVhcj48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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5KYW5zc29uPC9BdXRob3I+PFllYXI+MjAwNTwvWWVhcj48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ADDIN EN.CITE.DATA (48, 53). SMD values at post-treatment and follow-up for subjective outcomes are presented in table S2 and for objective outcomes are presented in table S3. [Insert table 1 here]Narrative synthesisCurrent evidence for the effect of CBT-I on subjective measures of cognitive functioningSeven RCTs administered a subjective measure of cognitive functioning. A significant improvement following the intervention compared to control was reported in three RCTs PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DYXNhdWx0PC9BdXRob3I+PFllYXI+MjAxNTwvWWVhcj48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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DYXNhdWx0PC9BdXRob3I+PFllYXI+MjAxNTwvWWVhcj48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ADDIN EN.CITE.DATA (47, 48, 52). The SMD at the post-intervention time-point was calculated for two of these studies PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DYXNhdWx0PC9BdXRob3I+PFllYXI+MjAxNTwvWWVhcj48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 EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DYXNhdWx0PC9BdXRob3I+PFllYXI+MjAxNTwvWWVhcj48
UmVjTnVtPjI1NTwvUmVjTnVtPjxEaXNwbGF5VGV4dD4oNDcsIDUyKTwvRGlzcGxheVRleHQ+PHJl
Y29yZD48cmVjLW51bWJlcj4yNTU8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0i
RU4iIGRiLWlkPSI1cHJ3ZTVzYTFzejJzcGVlZndyNXR4MG94ZHc5c3p6eHBhc3IiPjI1NTwva2V5
PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYt
dHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+Q2FzYXVsdCwgTC48L2F1dGhvcj48
YXV0aG9yPlNhdmFyZCwgSi48L2F1dGhvcj48YXV0aG9yPkl2ZXJzLCBILjwvYXV0aG9yPjxhdXRo
b3I+U2F2YXJkLCBNLiBILjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1h
ZGRyZXNzPlNjaG9vbCBvZiBQc3ljaG9sb2d5LCBVbml2ZXJzaXRlIExhdmFsLCBRdWViZWMsIFF1
ZWJlYywgRzFWIDBBNiwgQ2FuYWRhOyBDZW50cmUgZGUgcmVjaGVyY2hlIGR1IENIVSBkZSBRdWVi
ZWMgYW5kIENlbnRyZSBkZSByZWNoZXJjaGUgc3VyIGxlIGNhbmNlciwgVW5pdmVyc2l0ZSBMYXZh
bCwgMTEgQ290ZSBkdSBQYWxhaXMsIFF1ZWJlYywgRzFSIDJKNiwgQ2FuYWRhOyBDZW50cmUgaG9z
cGl0YWxpZXIgdW5pdmVyc2l0YWlyZSAoQ0hVKSBkZSBRdWViZWMsIDExLCBDb3RlIGR1IFBhbGFp
cywgUXVlYmVjLCBRdWViZWMsIEcxUiAySjYsIENhbmFkYS4mI3hEO1NjaG9vbCBvZiBQc3ljaG9s
b2d5LCBVbml2ZXJzaXRlIExhdmFsLCBRdWViZWMsIFF1ZWJlYywgRzFWIDBBNiwgQ2FuYWRhOyBD
ZW50cmUgZGUgcmVjaGVyY2hlIGR1IENIVSBkZSBRdWViZWMgYW5kIENlbnRyZSBkZSByZWNoZXJj
aGUgc3VyIGxlIGNhbmNlciwgVW5pdmVyc2l0ZSBMYXZhbCwgMTEgQ290ZSBkdSBQYWxhaXMsIFF1
ZWJlYywgRzFSIDJKNiwgQ2FuYWRhLiBFbGVjdHJvbmljIGFkZHJlc3M6IGpvc2VlLnNhdmFyZEBw
c3kudWxhdmFsLmNhLiYjeEQ7U2Nob29sIG9mIFBzeWNob2xvZ3ksIFVuaXZlcnNpdGUgTGF2YWws
IFF1ZWJlYywgUXVlYmVjLCBHMVYgMEE2LCBDYW5hZGE7IENlbnRyZSBkZSByZWNoZXJjaGUgZHUg
Q0hVIGRlIFF1ZWJlYyBhbmQgQ2VudHJlIGRlIHJlY2hlcmNoZSBzdXIgbGUgY2FuY2VyLCBVbml2
ZXJzaXRlIExhdmFsLCAxMSBDb3RlIGR1IFBhbGFpcywgUXVlYmVjLCBHMVIgMko2LCBDYW5hZGEu
JiN4RDtDZW50cmUgZGUgcmVjaGVyY2hlIGR1IENIVSBkZSBRdWViZWMgYW5kIENlbnRyZSBkZSBy
ZWNoZXJjaGUgc3VyIGxlIGNhbmNlciwgVW5pdmVyc2l0ZSBMYXZhbCwgMTEgQ290ZSBkdSBQYWxh
aXMsIFF1ZWJlYywgRzFSIDJKNiwgQ2FuYWRhLjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxl
PkEgcmFuZG9taXplZC1jb250cm9sbGVkIHRyaWFsIG9mIGFuIGVhcmx5IG1pbmltYWwgY29nbml0
aXZlLWJlaGF2aW91cmFsIHRoZXJhcHkgZm9yIGluc29tbmlhIGNvbW9yYmlkIHdpdGggY2FuY2Vy
PC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkJlaGF2IFJlcyBUaGVyPC9zZWNvbmRhcnktdGl0bGU+
PGFsdC10aXRsZT5CZWhhdmlvdXIgcmVzZWFyY2ggYW5kIHRoZXJhcHk8L2FsdC10aXRsZT48L3Rp
dGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5CZWhhdiBSZXMgVGhlcjwvZnVsbC10aXRsZT48
YWJici0xPkJlaGF2aW91ciByZXNlYXJjaCBhbmQgdGhlcmFweTwvYWJici0xPjwvcGVyaW9kaWNh
bD48YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+QmVoYXYgUmVzIFRoZXI8L2Z1bGwtdGl0bGU+
PGFiYnItMT5CZWhhdmlvdXIgcmVzZWFyY2ggYW5kIHRoZXJhcHk8L2FiYnItMT48L2FsdC1wZXJp
b2RpY2FsPjxwYWdlcz40NS01NDwvcGFnZXM+PHZvbHVtZT42Nzwvdm9sdW1lPjxlZGl0aW9uPjIw
MTUvMDMvMTA8L2VkaXRpb24+PGRhdGVzPjx5ZWFyPjIwMTU8L3llYXI+PHB1Yi1kYXRlcz48ZGF0
ZT5BcHI8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xODczLTYyMlggKEVsZWN0cm9u
aWMpJiN4RDswMDA1LTc5NjcgKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjI1NzQ2Nzc3
PC9hY2Nlc3Npb24tbnVtPjx3b3JrLXR5cGU+UmVzZWFyY2ggU3VwcG9ydCwgTm9uLVUuUy4gR292
JmFwb3M7dDwvd29yay10eXBlPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5j
YmkubmxtLm5paC5nb3YvcHVibWVkLzI1NzQ2Nzc3PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxz
PjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMDE2L2ouYnJhdC4yMDE1LjAyLjAwMzwvZWxl
Y3Ryb25pYy1yZXNvdXJjZS1udW0+PGxhbmd1YWdlPmVuZzwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9D
aXRlPjxDaXRlPjxBdXRob3I+Uml0dGVyYmFuZDwvQXV0aG9yPjxZZWFyPjIwMTI8L1llYXI+PFJl
Y051bT4yNzc8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjI3NzwvcmVjLW51bWJlcj48Zm9y
ZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9IjVwcndlNXNhMXN6MnNwZWVmd3I1dHgwb3hk
dzlzenp4cGFzciI+Mjc3PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJu
YWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5S
aXR0ZXJiYW5kLCBMLiBNLjwvYXV0aG9yPjxhdXRob3I+QmFpbGV5LCBFLiBULjwvYXV0aG9yPjxh
dXRob3I+VGhvcm5kaWtlLCBGLiBQLjwvYXV0aG9yPjxhdXRob3I+TG9yZCwgSC4gUi48L2F1dGhv
cj48YXV0aG9yPkZhcnJlbGwtQ2FybmFoYW4sIEwuPC9hdXRob3I+PGF1dGhvcj5CYXVtLCBMLiBE
LjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkRlcGFydG1l
bnQgb2YgUHN5Y2hpYXRyeSBhbmQgTmV1cm9iZWhhdmlvcmFsIFNjaWVuY2VzLCBVbml2ZXJzaXR5
IG9mIFZpcmdpbmlhIEhlYWx0aCBTeXN0ZW0sIENoYXJsb3R0ZXN2aWxsZSwgVkEgMjI5MDgsIFVT
QS4gbGVlckB2aXJnaW5pYS5lZHU8L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5Jbml0aWFs
IGV2YWx1YXRpb24gb2YgYW4gSW50ZXJuZXQgaW50ZXJ2ZW50aW9uIHRvIGltcHJvdmUgdGhlIHNs
ZWVwIG9mIGNhbmNlciBzdXJ2aXZvcnMgd2l0aCBpbnNvbW5pYTwvdGl0bGU+PHNlY29uZGFyeS10
aXRsZT5Qc3ljaG9vbmNvbG9neTwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+UHN5Y2hvLW9u
Y29sb2d5PC9hbHQtdGl0bGU+PC90aXRsZXM+PHBhZ2VzPjY5NS03MDU8L3BhZ2VzPjx2b2x1bWU+
MjE8L3ZvbHVtZT48bnVtYmVyPjc8L251bWJlcj48ZWRpdGlvbj4yMDExLzA1LzA0PC9lZGl0aW9u
PjxrZXl3b3Jkcz48a2V5d29yZD5BZHVsdDwva2V5d29yZD48a2V5d29yZD5Db2duaXRpdmUgVGhl
cmFweS8qbWV0aG9kczwva2V5d29yZD48a2V5d29yZD5GYXRpZ3VlL3BzeWNob2xvZ3kvdGhlcmFw
eTwva2V5d29yZD48a2V5d29yZD5GZW1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+Rm9sbG93LVVwIFN0
dWRpZXM8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPipJbnRlcm5l
dDwva2V5d29yZD48a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3b3JkPk1pZGRsZSBBZ2VkPC9r
ZXl3b3JkPjxrZXl3b3JkPk5lb3BsYXNtcy8qY29tcGxpY2F0aW9ucy9wc3ljaG9sb2d5Lyp0aGVy
YXB5PC9rZXl3b3JkPjxrZXl3b3JkPlBhdGllbnQgRWR1Y2F0aW9uIGFzIFRvcGljL21ldGhvZHM8
L2tleXdvcmQ+PGtleXdvcmQ+UXVhbGl0eSBvZiBMaWZlL3BzeWNob2xvZ3k8L2tleXdvcmQ+PGtl
eXdvcmQ+U2V2ZXJpdHkgb2YgSWxsbmVzcyBJbmRleDwva2V5d29yZD48a2V5d29yZD5TbGVlcCBJ
bml0aWF0aW9uIGFuZCBNYWludGVuYW5jZSBEaXNvcmRlcnMvKmV0aW9sb2d5L3BzeWNob2xvZ3kv
KnRoZXJhcHk8L2tleXdvcmQ+PGtleXdvcmQ+U3RyZXNzLCBQc3ljaG9sb2dpY2FsPC9rZXl3b3Jk
PjxrZXl3b3JkPlN1cnZpdm9ycy8qcHN5Y2hvbG9neTwva2V5d29yZD48a2V5d29yZD5UaGVyYXB5
LCBDb21wdXRlci1Bc3Npc3RlZC8qbWV0aG9kczwva2V5d29yZD48a2V5d29yZD5UcmVhdG1lbnQg
T3V0Y29tZTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDEyPC95ZWFyPjxwdWIt
ZGF0ZXM+PGRhdGU+SnVsPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTA5OS0xNjEx
IChFbGVjdHJvbmljKSYjeEQ7MTA1Ny05MjQ5IChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51
bT4yMTUzODY3ODwvYWNjZXNzaW9uLW51bT48d29yay10eXBlPlJhbmRvbWl6ZWQgQ29udHJvbGxl
ZCBUcmlhbCYjeEQ7UmVzZWFyY2ggU3VwcG9ydCwgTi5JLkguLCBFeHRyYW11cmFsJiN4RDtSZXNl
YXJjaCBTdXBwb3J0LCBOb24tVS5TLiBHb3YmYXBvczt0PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0
ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMjE1Mzg2Nzg8
L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGN1c3RvbTI+MzQyNDI3MDwvY3VzdG9tMj48ZWxl
Y3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTAwMi9wb24uMTk2OTwvZWxlY3Ryb25pYy1yZXNvdXJj
ZS1udW0+PGxhbmd1YWdlPmVuZzwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT4A
ADDIN EN.CITE.DATA (47, 52) (see figure 2). The study by Casault et al. PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DYXNhdWx0PC9BdXRob3I+PFllYXI+MjAxNTwvWWVhcj48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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DYXNhdWx0PC9BdXRob3I+PFllYXI+MjAxNTwvWWVhcj48
UmVjTnVtPjI1NTwvUmVjTnVtPjxEaXNwbGF5VGV4dD4oNDcpPC9EaXNwbGF5VGV4dD48cmVjb3Jk
PjxyZWMtbnVtYmVyPjI1NTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIg
ZGItaWQ9IjVwcndlNXNhMXN6MnNwZWVmd3I1dHgwb3hkdzlzenp4cGFzciI+MjU1PC9rZXk+PC9m
b3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBl
Pjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5DYXNhdWx0LCBMLjwvYXV0aG9yPjxhdXRo
b3I+U2F2YXJkLCBKLjwvYXV0aG9yPjxhdXRob3I+SXZlcnMsIEguPC9hdXRob3I+PGF1dGhvcj5T
YXZhcmQsIE0uIEguPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJl
c3M+U2Nob29sIG9mIFBzeWNob2xvZ3ksIFVuaXZlcnNpdGUgTGF2YWwsIFF1ZWJlYywgUXVlYmVj
LCBHMVYgMEE2LCBDYW5hZGE7IENlbnRyZSBkZSByZWNoZXJjaGUgZHUgQ0hVIGRlIFF1ZWJlYyBh
bmQgQ2VudHJlIGRlIHJlY2hlcmNoZSBzdXIgbGUgY2FuY2VyLCBVbml2ZXJzaXRlIExhdmFsLCAx
MSBDb3RlIGR1IFBhbGFpcywgUXVlYmVjLCBHMVIgMko2LCBDYW5hZGE7IENlbnRyZSBob3NwaXRh
bGllciB1bml2ZXJzaXRhaXJlIChDSFUpIGRlIFF1ZWJlYywgMTEsIENvdGUgZHUgUGFsYWlzLCBR
dWViZWMsIFF1ZWJlYywgRzFSIDJKNiwgQ2FuYWRhLiYjeEQ7U2Nob29sIG9mIFBzeWNob2xvZ3ks
IFVuaXZlcnNpdGUgTGF2YWwsIFF1ZWJlYywgUXVlYmVjLCBHMVYgMEE2LCBDYW5hZGE7IENlbnRy
ZSBkZSByZWNoZXJjaGUgZHUgQ0hVIGRlIFF1ZWJlYyBhbmQgQ2VudHJlIGRlIHJlY2hlcmNoZSBz
dXIgbGUgY2FuY2VyLCBVbml2ZXJzaXRlIExhdmFsLCAxMSBDb3RlIGR1IFBhbGFpcywgUXVlYmVj
LCBHMVIgMko2LCBDYW5hZGEuIEVsZWN0cm9uaWMgYWRkcmVzczogam9zZWUuc2F2YXJkQHBzeS51
bGF2YWwuY2EuJiN4RDtTY2hvb2wgb2YgUHN5Y2hvbG9neSwgVW5pdmVyc2l0ZSBMYXZhbCwgUXVl
YmVjLCBRdWViZWMsIEcxViAwQTYsIENhbmFkYTsgQ2VudHJlIGRlIHJlY2hlcmNoZSBkdSBDSFUg
ZGUgUXVlYmVjIGFuZCBDZW50cmUgZGUgcmVjaGVyY2hlIHN1ciBsZSBjYW5jZXIsIFVuaXZlcnNp
dGUgTGF2YWwsIDExIENvdGUgZHUgUGFsYWlzLCBRdWViZWMsIEcxUiAySjYsIENhbmFkYS4mI3hE
O0NlbnRyZSBkZSByZWNoZXJjaGUgZHUgQ0hVIGRlIFF1ZWJlYyBhbmQgQ2VudHJlIGRlIHJlY2hl
cmNoZSBzdXIgbGUgY2FuY2VyLCBVbml2ZXJzaXRlIExhdmFsLCAxMSBDb3RlIGR1IFBhbGFpcywg
UXVlYmVjLCBHMVIgMko2LCBDYW5hZGEuPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+QSBy
YW5kb21pemVkLWNvbnRyb2xsZWQgdHJpYWwgb2YgYW4gZWFybHkgbWluaW1hbCBjb2duaXRpdmUt
YmVoYXZpb3VyYWwgdGhlcmFweSBmb3IgaW5zb21uaWEgY29tb3JiaWQgd2l0aCBjYW5jZXI8L3Rp
dGxlPjxzZWNvbmRhcnktdGl0bGU+QmVoYXYgUmVzIFRoZXI8L3NlY29uZGFyeS10aXRsZT48YWx0
LXRpdGxlPkJlaGF2aW91ciByZXNlYXJjaCBhbmQgdGhlcmFweTwvYWx0LXRpdGxlPjwvdGl0bGVz
PjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkJlaGF2IFJlcyBUaGVyPC9mdWxsLXRpdGxlPjxhYmJy
LTE+QmVoYXZpb3VyIHJlc2VhcmNoIGFuZCB0aGVyYXB5PC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxh
bHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5CZWhhdiBSZXMgVGhlcjwvZnVsbC10aXRsZT48YWJi
ci0xPkJlaGF2aW91ciByZXNlYXJjaCBhbmQgdGhlcmFweTwvYWJici0xPjwvYWx0LXBlcmlvZGlj
YWw+PHBhZ2VzPjQ1LTU0PC9wYWdlcz48dm9sdW1lPjY3PC92b2x1bWU+PGVkaXRpb24+MjAxNS8w
My8xMDwvZWRpdGlvbj48ZGF0ZXM+PHllYXI+MjAxNTwveWVhcj48cHViLWRhdGVzPjxkYXRlPkFw
cjwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE4NzMtNjIyWCAoRWxlY3Ryb25pYykm
I3hEOzAwMDUtNzk2NyAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MjU3NDY3Nzc8L2Fj
Y2Vzc2lvbi1udW0+PHdvcmstdHlwZT5SZXNlYXJjaCBTdXBwb3J0LCBOb24tVS5TLiBHb3YmYXBv
czt0PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5u
bG0ubmloLmdvdi9wdWJtZWQvMjU3NDY3Nzc8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGVs
ZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEwMTYvai5icmF0LjIwMTUuMDIuMDAzPC9lbGVjdHJv
bmljLXJlc291cmNlLW51bT48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+
PC9FbmROb3RlPn==
ADDIN EN.CITE.DATA (47) in cancer patients, demonstrated an improvement in scores on the cognitive functioning subscale of the QLQ-C30 at post-intervention, in the group that received minimal CBT-I compared to a no treatment control group. This difference was not maintained at the 12 or 24-week follow-up, due to improvement in scores in the control group (see figure 4). The study by Ritterband et al. PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5SaXR0ZXJiYW5kPC9BdXRob3I+PFllYXI+MjAxMjwvWWVh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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5SaXR0ZXJiYW5kPC9BdXRob3I+PFllYXI+MjAxMjwvWWVh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ADDIN EN.CITE.DATA (52) reported a greater improvement in mental fatigue in the group that received internet delivered CBT-I (SHUTi) compared to control. Our calculations of SMD revealed no significant difference between the groups in mental fatigue at the post-intervention time-point. This discrepancy is likely due to the fact that post-intervention SMD does not take baseline scores into account. In this RCT, in spite of random allocation, there were significant differences between the groups at baseline in the variables sex and type of cancer, which were not adjusted for in the analysis. Moreover, participants in the SHUTi group displayed higher levels of mental fatigue than participants in the control group at baseline and therefore the significant improvement in the intervention group could be explained by regression towards the mean. Thus, the results from this study should be interpreted with caution.[Insert figure 2 here]The study by Jansson and Linton PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5KYW5zc29uPC9BdXRob3I+PFllYXI+MjAwNTwvWWVhcj48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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5KYW5zc29uPC9BdXRob3I+PFllYXI+MjAwNTwvWWVhcj48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ADDIN EN.CITE.DATA (48) evaluated the impact of CBT-I on difficulties with concentration, one-year post intervention. They reported significantly greater improvements in concentration between baseline and follow-up in the CBT-I group compared to control, however our calculations of SMD revealed that the groups were not significantly different at follow-up (SMD = 0.19). Similar to the study by Ritterband et al. PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5SaXR0ZXJiYW5kPC9BdXRob3I+PFllYXI+MjAxMjwvWWVh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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5SaXR0ZXJiYW5kPC9BdXRob3I+PFllYXI+MjAxMjwvWWVh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ADDIN EN.CITE.DATA (52), this discrepancy is likely due to the fact that post-intervention SMD does not take baseline scores into account. In this study there was attrition between randomisation and follow-up (17.6%), which may have introduced bias. The researchers reported that individuals who dropped out were not significantly different from those who completed the study in terms of demographic or clinical data (including concentration difficulties) and there was no differential loss of participants across the groups. However, an intention-to-treat analysis of the data was not performed and therefore potential bias from attrition is possible. The lack of statistically significant differences between the groups at follow-up may be explained by low sensitivity of the measure utilised and the long period of time between intervention and follow-up, during which the impact of the intervention may have diminished (see figure 4). Four RCTs reported a non-significant difference between groups in change in subjective cognitive outcomes between baseline and post-intervention PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NYXR0aGV3czwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NYXR0aGV3czwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+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ADDIN EN.CITE.DATA (45, 46, 49, 54). The study by Matthews et al. PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NYXR0aGV3czwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NYXR0aGV3czwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+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ADDIN EN.CITE.DATA (49) demonstrated a trend towards a significant group x time interaction for scores on the AFI. The reported effect size was moderate (Cohens d = 0.56) and therefore the lack of statistical significance is likely due to insufficient power. Our calculations of SMD showed a significant difference between the group that received CBT-I and the group that received BPT in scores on the AFI at the post-intervention time point, which was maintained at the 12 week follow-up but not the 24 week follow-up. Two studies using active controls (BPT and a CBT-I self-help information pamphlet) showed significant improvements in mental fatigue between baseline and post-intervention, for both the intervention groups and the control groups PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bcm5lZHQ8L0F1dGhvcj48WWVhcj4yMDExPC9ZZWFyPjxS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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bcm5lZHQ8L0F1dGhvcj48WWVhcj4yMDExPC9ZZWFyPjxS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ADDIN EN.CITE.DATA (45, 46). For both of these studies, improvements were larger in the intervention groups, however differences were not statistically significant. Finally, the study by Taylor et al PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5UYXlsb3I8L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxS
ZWNOdW0+Mjg0PC9SZWNOdW0+PERpc3BsYXlUZXh0Pig1NCk8L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+
PHJlYy1udW1iZXI+Mjg0PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBk
Yi1pZD0iNXByd2U1c2Exc3oyc3BlZWZ3cjV0eDBveGR3OXN6enhwYXNyIj4yODQ8L2tleT48L2Zv
cmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+
PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPlRheWxvciwgRC4gSi48L2F1dGhvcj48YXV0
aG9yPlppbW1lcm1hbiwgTS4gUi48L2F1dGhvcj48YXV0aG9yPkdhcmRuZXIsIEMuIEUuPC9hdXRo
b3I+PGF1dGhvcj5XaWxsaWFtcywgSi4gTS48L2F1dGhvcj48YXV0aG9yPkdyaWVzZXIsIEUuIEEu
PC9hdXRob3I+PGF1dGhvcj5UYXR1bSwgSi4gSS48L2F1dGhvcj48YXV0aG9yPkJyYW1vd2V0aCwg
QS4gRC48L2F1dGhvcj48YXV0aG9yPkZyYW5jZXRpY2gsIEouIE0uPC9hdXRob3I+PGF1dGhvcj5S
dWdnZXJvLCBDLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNz
PlVuaXZlcnNpdHkgb2YgTm9ydGggVGV4YXMuIEVsZWN0cm9uaWMgYWRkcmVzczogZGp0YXlsb3JA
dW50LmVkdS4mI3hEO1VuaXZlcnNpdHkgb2YgTm9ydGggVGV4YXMuJiN4RDtUZXhhcyBUZWNoIFVu
aXZlcnNpdHkuJiN4RDtUaGUgVW5pdmVyc2l0eSBvZiBUZXhhcyBIZWFsdGggU2NpZW5jZSBDZW50
ZXIgYXQgU2FuIEFudG9uaW8uJiN4RDtXaWxmb3JkIEhhbGwgQW1idWxhdG9yeSBTdXJnaWNhbCBD
ZW50ZXIuJiN4RDtXcmlnaHQtUGF0dGVyc29uIE1lZGljYWwgQ2VudGVyLiYjeEQ7VkEgUGl0dHNi
dXJnaCBIZWFsdGhjYXJlIFN5c3RlbS4mI3hEO1VuaXZlcnNpdHkgb2YgTm9ydGggVGV4YXMsIERl
cGFydG1lbnQgb2YgUHN5Y2hvbG9neS48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5BIHBp
bG90IHJhbmRvbWl6ZWQgY29udHJvbGxlZCB0cmlhbCBvZiB0aGUgZWZmZWN0cyBvZiBjb2duaXRp
dmUtYmVoYXZpb3JhbCB0aGVyYXB5IGZvciBpbnNvbW5pYSBvbiBzbGVlcCBhbmQgZGF5dGltZSBm
dW5jdGlvbmluZyBpbiBjb2xsZWdlIHN0dWRlbnRzPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkJl
aGF2IFRoZXI8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkJlaGF2aW9yIHRoZXJhcHk8L2Fs
dC10aXRsZT48L3RpdGxlcz48cGFnZXM+Mzc2LTg5PC9wYWdlcz48dm9sdW1lPjQ1PC92b2x1bWU+
PG51bWJlcj4zPC9udW1iZXI+PGVkaXRpb24+MjAxNC8wNC8wMTwvZWRpdGlvbj48a2V5d29yZHM+
PGtleXdvcmQ+QWN0aWdyYXBoeS9tZXRob2RzPC9rZXl3b3JkPjxrZXl3b3JkPkFkb2xlc2NlbnQ8
L2tleXdvcmQ+PGtleXdvcmQ+QWR1bHQ8L2tleXdvcmQ+PGtleXdvcmQ+Q29nbml0aW9uLypwaHlz
aW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPkNvZ25pdGl2ZSBUaGVyYXB5LyptZXRob2RzPC9rZXl3
b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29yZD5Gb2xsb3ctVXAgU3R1ZGllczwv
a2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48
a2V5d29yZD5TbGVlcC8qcGh5c2lvbG9neTwva2V5d29yZD48a2V5d29yZD5TbGVlcCBJbml0aWF0
aW9uIGFuZCBNYWludGVuYW5jZSBEaXNvcmRlcnMvZGlhZ25vc2lzL3BzeWNob2xvZ3kvKnRoZXJh
cHk8L2tleXdvcmQ+PGtleXdvcmQ+KlN0dWRlbnRzPC9rZXl3b3JkPjxrZXl3b3JkPlN1cnZleXMg
YW5kIFF1ZXN0aW9ubmFpcmVzPC9rZXl3b3JkPjxrZXl3b3JkPlRpbWUgRmFjdG9yczwva2V5d29y
ZD48a2V5d29yZD5UcmVhdG1lbnQgT3V0Y29tZTwva2V5d29yZD48a2V5d29yZD5Zb3VuZyBBZHVs
dDwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDE0PC95ZWFyPjxwdWItZGF0ZXM+
PGRhdGU+TWF5PC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTg3OC0xODg4IChFbGVj
dHJvbmljKSYjeEQ7MDAwNS03ODk0IChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4yNDY4
MDIzMjwvYWNjZXNzaW9uLW51bT48d29yay10eXBlPlJhbmRvbWl6ZWQgQ29udHJvbGxlZCBUcmlh
bCYjeEQ7UmVzZWFyY2ggU3VwcG9ydCwgTm9uLVUuUy4gR292JmFwb3M7dDwvd29yay10eXBlPjx1
cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVk
LzI0NjgwMjMyPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNl
LW51bT4xMC4xMDE2L2ouYmV0aC4yMDEzLjEyLjAxMDwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+
PGxhbmd1YWdlPmVuZzwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT5=
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5UYXlsb3I8L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxS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=
ADDIN EN.CITE.DATA (54) showed no effect of CBT-I on mental fatigue in college students. The authors suggest that this may be due to possible floor effects. There were five uncontrolled trials that administered a subjective measure of cognitive functioning PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bcm5lZHQ8L0F1dGhvcj48WWVhcj4yMDA3PC9ZZWFyPjxS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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bcm5lZHQ8L0F1dGhvcj48WWVhcj4yMDA3PC9ZZWFyPjxS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ADDIN EN.CITE.DATA (56-60). Three of these studies reported significant improvements between baseline and post-intervention PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MYW1pPC9BdXRob3I+PFllYXI+MjAxNjwvWWVhcj48UmVj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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MYW1pPC9BdXRob3I+PFllYXI+MjAxNjwvWWVhcj48UmVj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ADDIN EN.CITE.DATA (58-60) and one study reported a trend for improved cognitive functioning ADDIN EN.CITE <EndNote><Cite><Author>Davidson</Author><Year>2001</Year><RecNum>258</RecNum><DisplayText>(57)</DisplayText><record><rec-number>258</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr">258</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Davidson, J. R.</author><author>Waisberg, J. L.</author><author>Brundage, M. D.</author><author>MacLean, A. W.</author></authors></contributors><auth-address>Department of Psychology, Queen's University, Kingston, Ontario, Canada. davidsnj@post.queensu.ca</auth-address><titles><title>Nonpharmacologic group treatment of insomnia: a preliminary study with cancer survivors</title><secondary-title>Psychooncology</secondary-title><alt-title>Psycho-oncology</alt-title></titles><pages>389-97</pages><volume>10</volume><number>5</number><edition>2001/09/06</edition><keywords><keyword>Attitude to Health</keyword><keyword>Cognitive Therapy/*methods</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Longitudinal Studies</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Neoplasms/*complications/psychology/therapy</keyword><keyword>Patient Education as Topic/*methods</keyword><keyword>Program Evaluation</keyword><keyword>*Relaxation Therapy</keyword><keyword>Severity of Illness Index</keyword><keyword>Sleep Initiation and Maintenance Disorders/*etiology/psychology/*therapy</keyword><keyword>*Survivors/psychology</keyword><keyword>Time Factors</keyword><keyword>Treatment Outcome</keyword></keywords><dates><year>2001</year><pub-dates><date>Sep-Oct</date></pub-dates></dates><isbn>1057-9249 (Print)
1057-9249 (Linking)</isbn><accession-num>11536417</accession-num><work-type>Clinical Trial
Controlled Clinical Trial
Research Support, Non-U.S. Gov't</work-type><urls><related-urls><url>;(57). The studies that did not find a statistically significant improvement had small samples (N = 14 and N = 7). The case series conducted by Quesnel et al. ADDIN EN.CITE <EndNote><Cite><Author>Quesnel</Author><Year>2003</Year><RecNum>276</RecNum><DisplayText>(62)</DisplayText><record><rec-number>276</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr">276</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Quesnel, C.</author><author>Savard, J.</author><author>Simard, S.</author><author>Ivers, H.</author><author>Morin, C. M.</author></authors></contributors><auth-address>School of Psychology and Cancer Research Centre, Universite Laval, Quebec, Quebec, Canada.</auth-address><titles><title>Efficacy of cognitive-behavioral therapy for insomnia in women treated for nonmetastatic breast cancer</title><secondary-title>J Consult Clin Psychol</secondary-title><alt-title>Journal of consulting and clinical psychology</alt-title></titles><periodical><full-title>J Consult Clin Psychol</full-title></periodical><pages>189-200</pages><volume>71</volume><number>1</number><edition>2003/02/27</edition><keywords><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Breast Neoplasms/*psychology</keyword><keyword>Cognitive Therapy/*methods</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Middle Aged</keyword><keyword>Polysomnography</keyword><keyword>Quality of Life</keyword><keyword>Sleep Initiation and Maintenance Disorders/diagnosis/*etiology/*therapy</keyword><keyword>Surveys and Questionnaires</keyword></keywords><dates><year>2003</year><pub-dates><date>Feb</date></pub-dates></dates><isbn>0022-006X (Print)
0022-006X (Linking)</isbn><accession-num>12602439</accession-num><work-type>Clinical Trial
Research Support, Non-U.S. Gov't</work-type><urls><related-urls><url>;(62) reported a significant improvement in score on the QLQ-C30 between baseline and post-intervention, which was maintained at follow-up. The non-randomised controlled trial reported by Simeit et al. ADDIN EN.CITE <EndNote><Cite><Author>Simeit</Author><Year>2004</Year><RecNum>279</RecNum><DisplayText>(61)</DisplayText><record><rec-number>279</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr">279</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Simeit, R.</author><author>Deck, R.</author><author>Conta-Marx, B.</author></authors></contributors><auth-address>Ropersbergklinik Ratzeburg, Ropersberg 47, 23909 Ratzeburg, Germany. info@rkrz.de</auth-address><titles><title>Sleep management training for cancer patients with insomnia</title><secondary-title>Support Care Cancer</secondary-title><alt-title>Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer</alt-title></titles><pages>176-83</pages><volume>12</volume><number>3</number><edition>2004/02/05</edition><keywords><keyword>Attitude to Health</keyword><keyword>Female</keyword><keyword>Health Care Surveys</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Neoplasms/*complications/psychology</keyword><keyword>Patient Education as Topic/*methods</keyword><keyword>Program Evaluation</keyword><keyword>Quality of Life</keyword><keyword>Relaxation Therapy/*education</keyword><keyword>Sleep Initiation and Maintenance Disorders/prevention & control/*rehabilitation</keyword><keyword>Surveys and Questionnaires</keyword></keywords><dates><year>2004</year><pub-dates><date>Mar</date></pub-dates></dates><isbn>0941-4355 (Print)
0941-4355 (Linking)</isbn><accession-num>14760542</accession-num><work-type>Clinical Trial
Controlled Clinical Trial
Research Support, Non-U.S. Gov't</work-type><urls><related-urls><url>;(61) reported that all groups showed significant improvements in self-report cognitive functioning between baseline and follow-up. There were no significant group x time interactions. The weight of evidence from the non-randomised control trial, case series and uncontrolled trials point to positive effects of CBT-I on subjective measures of cognitive functioning. However the risk of bias in these studies is high. Evidence from the RCTs included in this review is mixed and only two RCTs PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DYXNhdWx0PC9BdXRob3I+PFllYXI+MjAxNTwvWWVhcj48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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DYXNhdWx0PC9BdXRob3I+PFllYXI+MjAxNTwvWWVhcj48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ADDIN EN.CITE.DATA (47) demonstrated a significant difference between groups at the post-intervention time point. There is a great deal of heterogeneity within the included studies and factors which differentiate between those RCTs that report significant improvements in cognitive functioning following the intervention, and those RCTs that report non-significant findings, are not clearly discernible. Our SMD calculations suggest that on the whole, CBT-I is associated with larger improvements in subjective measures of cognitive functioning compared to control, however confidence intervals are large, reflecting the small sample size and low statistical power (eight out of the eleven RCTs had N ≤ 60 which means that studies would only have the ability to detect an effect size f of 0.37), limiting the conclusions that can be drawn. Current evidence for the effect of CBT-I on objective measures of cognitive functioningFour RCTs evaluated the impact of CBT-I on objective measures of cognitive functioning PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NaXJvPC9BdXRob3I+PFllYXI+MjAxMTwvWWVhcj48UmVj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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NaXJvPC9BdXRob3I+PFllYXI+MjAxMTwvWWVhcj48UmVj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ADDIN EN.CITE.DATA (50, 51, 53, 55). Two of these studies reported positive findings PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NaXJvPC9BdXRob3I+PFllYXI+MjAxMTwvWWVhcj48UmVj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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NaXJvPC9BdXRob3I+PFllYXI+MjAxMTwvWWVhcj48UmVj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ADDIN EN.CITE.DATA (50, 53) and two studies reported null findings PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5PbXZpazwvQXV0aG9yPjxZZWFyPjIwMDg8L1llYXI+PFJl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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5PbXZpazwvQXV0aG9yPjxZZWFyPjIwMDg8L1llYXI+PFJl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ADDIN EN.CITE.DATA (51, 55). SMD for objective measures at post-intervention are presented in figure 3. The study by Miro et al. PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NaXJvPC9BdXRob3I+PFllYXI+MjAxMTwvWWVhcj48UmVj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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NaXJvPC9BdXRob3I+PFllYXI+MjAxMTwvWWVhcj48UmVj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ADDIN EN.CITE.DATA (50) in individuals with fibromyalgia found greater improvements in two aspects of attention (alerting and executive control) in the intervention group compared to the control group. Our calculation of SMD revealed no significant difference between the groups on any aspect of performance on the ANT-I task at the post-intervention time-point. This discrepancy may be due to baseline differences between the groups in age, which were adjusted for in the statistical analysis performed by Miro et al. The study by Sun et al. ADDIN EN.CITE <EndNote><Cite><Author>Sun</Author><Year>2013</Year><RecNum>280</RecNum><DisplayText>(53)</DisplayText><record><rec-number>280</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr">280</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Sun, J.</author><author>Kang, J.</author><author>Wang, P.</author><author>Zeng, H.</author></authors></contributors><auth-address>School of Nursing, Central South University, Changsha, Hunan Province, China.</auth-address><titles><title>Self-relaxation training can improve sleep quality and cognitive functions in the older: a one-year randomised controlled trial</title><secondary-title>J Clin Nurs</secondary-title><alt-title>Journal of clinical nursing</alt-title></titles><pages>1270-80</pages><volume>22</volume><number>9-10</number><edition>2013/04/12</edition><keywords><keyword>Adolescent</keyword><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Aged, 80 and over</keyword><keyword>Analysis of Variance</keyword><keyword>Child</keyword><keyword>*Cognition</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Patient Education as Topic/*methods</keyword><keyword>*Relaxation Therapy</keyword><keyword>*Self Care</keyword><keyword>*Sleep</keyword><keyword>Surveys and Questionnaires</keyword><keyword>Young Adult</keyword></keywords><dates><year>2013</year><pub-dates><date>May</date></pub-dates></dates><isbn>1365-2702 (Electronic)
0962-1067 (Linking)</isbn><accession-num>23574290</accession-num><work-type>Randomized Controlled Trial
Research Support, Non-U.S. Gov't</work-type><urls><related-urls><url>;(53) reported improvements in scores on the MMSE and the WMS-CR following the intervention, which became larger at subsequent follow-ups. These findings were corroborated by our calculations of SMD, which showed statistically significant differences between groups on scores on the MMSE and WMS-CR at each of the follow-up time-points (12, 24 and 52 weeks) (see figure 4). In this study, participants were provided with sleep hygiene information and were taught relaxation skills which they were encouraged to practice both individually and within groups, for a period of one year. Performance on cognitive tests was compared to a group that received sleep hygiene information only. The large effects observed in this study may be explained by non-specific effects of the intervention such as participant expectations of improvement and the increased social contact provided by group relaxation practice. In addition, researchers administering the neuropsychological tests were not blind to group assignment, which may have led to an exaggeration of treatment effects through ascertainment bias. [Insert figure 3 here][Insert figure 4 here]The study by Wilckens et al. ADDIN EN.CITE <EndNote><Cite><Author>Wilckens</Author><Year>2016</Year><RecNum>288</RecNum><DisplayText>(55)</DisplayText><record><rec-number>288</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr">288</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Wilckens, K. A.</author><author>Hall, M. H.</author><author>Nebes, R. D.</author><author>Monk, T. H.</author><author>Buysse, D. J.</author></authors></contributors><auth-address>a Department of Psychiatry , University of Pittsburgh School of Medicine , USA.</auth-address><titles><title>Changes in Cognitive Performance Are Associated with Changes in Sleep in Older Adults With Insomnia</title><secondary-title>Behav Sleep Med</secondary-title><alt-title>Behavioral sleep medicine</alt-title></titles><periodical><full-title>Behav Sleep Med</full-title><abbr-1>Behavioral sleep medicine</abbr-1></periodical><alt-periodical><full-title>Behav Sleep Med</full-title><abbr-1>Behavioral sleep medicine</abbr-1></alt-periodical><pages>295-310</pages><volume>14</volume><number>3</number><edition>2015/09/01</edition><dates><year>2016</year><pub-dates><date>May-Jun</date></pub-dates></dates><isbn>1540-2010 (Electronic)
1540-2002 (Linking)</isbn><accession-num>26322904</accession-num><urls><related-urls><url>;(55) examined the impact of brief behavioural treatment for insomnia (BBTI) on cognitive functioning in older adults. BBTI focuses on the behavioural aspects of CBT-I and utilises stimulus control and sleep restriction. In this study they found no significant difference between the groups on change in performance on the cognitive tests. One possible reason for null findings is the short duration between baseline and post-intervention (4 weeks). A greater decrease in TST at the post-intervention time point was reported in the intervention group, which is likely a result of sleep restriction therapy (SRT). SRT has been associated with increases in daytime sleepiness and impairments in vigilance during the acute phase PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LeWxlPC9BdXRob3I+PFllYXI+MjAxNDwvWWVhcj48UmVj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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LeWxlPC9BdXRob3I+PFllYXI+MjAxNDwvWWVhcj48UmVj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ADDIN EN.CITE.DATA (75). Therefore, the side-effects of sleep restriction may have impacted on performance on cognitive tests, contributing to null findings. In addition the time of day at which the cognitive tests were administered was not controlled for, and this may have introduced additional variance, possibly obscuring the effects of the intervention ADDIN EN.CITE <EndNote><Cite><Author>Schmidt</Author><Year>2007</Year><RecNum>489</RecNum><DisplayText>(76)</DisplayText><record><rec-number>489</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr">489</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Schmidt, C.</author><author>Collette, F.</author><author>Cajochen, C.</author><author>Peigneux, P.</author></authors></contributors><auth-address>Cyclotron Research Centre, University of Liege, Liege, Belgium.</auth-address><titles><title>A time to think: circadian rhythms in human cognition</title><secondary-title>Cogn Neuropsychol</secondary-title><alt-title>Cognitive neuropsychology</alt-title></titles><periodical><full-title>Cogn Neuropsychol</full-title><abbr-1>Cognitive neuropsychology</abbr-1></periodical><alt-periodical><full-title>Cogn Neuropsychol</full-title><abbr-1>Cognitive neuropsychology</abbr-1></alt-periodical><pages>755-89</pages><volume>24</volume><number>7</number><keywords><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Aging/*psychology</keyword><keyword>Arousal</keyword><keyword>Attention</keyword><keyword>*Circadian Rhythm</keyword><keyword>*Cognition</keyword><keyword>Humans</keyword><keyword>Individuality</keyword><keyword>Inhibition (Psychology)</keyword><keyword>Memory</keyword><keyword>Middle Aged</keyword><keyword>Neuropsychological Tests</keyword><keyword>Problem Solving</keyword><keyword>Psychomotor Performance</keyword><keyword>Sleep</keyword><keyword>*Thinking</keyword><keyword>Wakefulness</keyword></keywords><dates><year>2007</year><pub-dates><date>Oct</date></pub-dates></dates><isbn>1464-0627 (Electronic)
0264-3294 (Linking)</isbn><accession-num>18066734</accession-num><urls><related-urls><url>;(76). The study by Omvik et al. PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5PbXZpazwvQXV0aG9yPjxZZWFyPjIwMDg8L1llYXI+PFJl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=
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5PbXZpazwvQXV0aG9yPjxZZWFyPjIwMDg8L1llYXI+PFJl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=
ADDIN EN.CITE.DATA (51) compared the effects of CBT-I and Zopiclone on sustained attention. They found the number of correct responses on the vigilance task significantly worsened in the CBT-I group between baseline and post-intervention. Again, this may be related to the short-term effects of SRT PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LeWxlPC9BdXRob3I+PFllYXI+MjAxNDwvWWVhcj48UmVj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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LeWxlPC9BdXRob3I+PFllYXI+MjAxNDwvWWVhcj48UmVj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ADDIN EN.CITE.DATA (75). However, there were no significant group x time interactions for any index of performance on the vigilance task, either at post-intervention or follow-up. This study had a very small sample size (N=45) and an active control. Therefore, the lack of group x time interactions may reflect insufficient statistical power to detect small effects. The authors did not account for participants who dropped out of the study and therefore attrition bias may also be a factor. We identified few studies that evaluated the impact of CBT-I on objective measures of cognitive functioning. The evidence from the studies included in this review is mixed. Heterogeneity in the nature of the tasks used to probe cognitive functioning may contribute to the disparate findings. Confidence intervals for SMD at post-intervention and follow-up tend to be smaller for objective measures of cognitive functioning compared to the subjective measures of cognitive functioning, reflecting more precise measurement of constructs. Relationship between sleep and cognitive functioningThree studies examined the relationship between changes in sleep and changes in cognitive functioning, from pre to post-intervention PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NaXJvPC9BdXRob3I+PFllYXI+MjAxMTwvWWVhcj48UmVj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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NaXJvPC9BdXRob3I+PFllYXI+MjAxMTwvWWVhcj48UmVj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ADDIN EN.CITE.DATA (50, 51, 55). The study by Omvik et al. PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5PbXZpazwvQXV0aG9yPjxZZWFyPjIwMDg8L1llYXI+PFJl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=
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5PbXZpazwvQXV0aG9yPjxZZWFyPjIwMDg8L1llYXI+PFJl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=
ADDIN EN.CITE.DATA (51) reported no significant associations between change in sleep efficiency or slow wave sleep and change in performance on the vigilance task. The study by Wilckens et al. ADDIN EN.CITE <EndNote><Cite><Author>Wilckens</Author><Year>2016</Year><RecNum>288</RecNum><DisplayText>(55)</DisplayText><record><rec-number>288</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr">288</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Wilckens, K. A.</author><author>Hall, M. H.</author><author>Nebes, R. D.</author><author>Monk, T. H.</author><author>Buysse, D. J.</author></authors></contributors><auth-address>a Department of Psychiatry , University of Pittsburgh School of Medicine , USA.</auth-address><titles><title>Changes in Cognitive Performance Are Associated with Changes in Sleep in Older Adults With Insomnia</title><secondary-title>Behav Sleep Med</secondary-title><alt-title>Behavioral sleep medicine</alt-title></titles><periodical><full-title>Behav Sleep Med</full-title><abbr-1>Behavioral sleep medicine</abbr-1></periodical><alt-periodical><full-title>Behav Sleep Med</full-title><abbr-1>Behavioral sleep medicine</abbr-1></alt-periodical><pages>295-310</pages><volume>14</volume><number>3</number><edition>2015/09/01</edition><dates><year>2016</year><pub-dates><date>May-Jun</date></pub-dates></dates><isbn>1540-2010 (Electronic)
1540-2002 (Linking)</isbn><accession-num>26322904</accession-num><urls><related-urls><url>;(55) calculated correlations between change in performance on cognitive tests and change in WASO, delta power (absolute and relative) and sigma power (absolute and relative). They found a significant positive association between increased absolute delta power and improved abstract reasoning. In addition, decreased relative sigma power was significantly associated with improvements in abstract reasoning. Neither of these associations was moderated by treatment group. There were no significant associations between change in sleep and change in performance on delayed recall or working memory tasks. Enhanced delta power, and a corresponding decrease in sigma power, may benefit brain regions that sub-serve executive functions in older adults, however BBTI does not appear to drive these relationships. Miro et al. PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NaXJvPC9BdXRob3I+PFllYXI+MjAxMTwvWWVhcj48UmVj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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NaXJvPC9BdXRob3I+PFllYXI+MjAxMTwvWWVhcj48UmVj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ADDIN EN.CITE.DATA (50) calculated the association between change in sleep quality and change in performance on the ANT-I. They found a significant positive association between sleep quality and performance on the attention control index from the ANT-I, which is proposed to be a measure of executive functioning. There were no significant associations between change in sleep quality and any other index of the ANT-I. On the basis of these results, Miro et al. concluded that improvements in sleep quality are associated with better executive functioning in individuals with fibromyalgia. Associations between changes in sleep and changes in cognitive functioning were exploratory outcomes in these trials and there was, therefore, limited correction for multiple testing, which increases the chances that some of the significant associations uncovered are due to type-one error. There were no studies that conducted mediation analyses to assess whether CBT may influence cognitive outcomes via temporally-separated mediators (e.g., insomnia severity, sleep continuity). The associations reported do not provide evidence with regards to the direction of the effect and experimental manipulations are required in order to determine whether there are specific aspects of sleep architecture that are causally related to cognitive performance. In spite of these limitations, these findings do highlight possible variables to target in future treatments seeking to deliver sleep-related cognitive improvement. DiscussionSummary of evidenceThe aim of this review was to summarise the literature and evaluate evidence for the effects of CBT-I on cognitive functioning. Using broad inclusion criteria, we identified 18 relevant studies. For the majority of these studies, cognition was a secondary outcome and assessed within a general measure of self-reported daytime functioning. Only four of the included studies administered an objective measure of cognitive functioning and across these studies, the range of cognitive domains examined was limited. The lack of research into the impact of CBT-I on cognitive functioning is surprising, given that impairments in concentration and memory are among the most commonly reported and most troubling daytime symptoms of insomnia PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LeWxlPC9BdXRob3I+PFllYXI+MjAxMzwvWWVhcj48UmVj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=
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LeWxlPC9BdXRob3I+PFllYXI+MjAxMzwvWWVhcj48UmVj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=
ADDIN EN.CITE.DATA (35). On the basis of post-intervention and follow-up SMDs, the majority of studies showed small to moderate effects of CBT-I on cognition. Three of the included studies reported statistically significant improvements, which our calculation of SMD at post-intervention/follow-up did not corroborate. Baseline imbalances resulting from small sample sizes or failure in randomisation may have contributed to the reported significant improvements in the intervention group compared to the control group. The included studies generally had small samples with limited statistical power to detect less than large effects. There was one high quality RCT, which incorporated an active control condition, participant blinding and utilised intention-to-treat analysis to minimise bias from attrition PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NYXR0aGV3czwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NYXR0aGV3czwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+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ADDIN EN.CITE.DATA (49). This study found a trend for a significant effect of CBT-I on self-report attentional function, with a moderate effect size. SMD at post-intervention and 12-week follow-up demonstrated a significant difference between the intervention and active control groups. On the basis of this study and other lower quality RCTs and uncontrolled trials PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DYXNhdWx0PC9BdXRob3I+PFllYXI+MjAxNTwvWWVhcj48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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DYXNhdWx0PC9BdXRob3I+PFllYXI+MjAxNTwvWWVhcj48
UmVjTnVtPjI1NTwvUmVjTnVtPjxEaXNwbGF5VGV4dD4oNDcsIDQ4LCA1MiwgNTgtNjApPC9EaXNw
bGF5VGV4dD48cmVjb3JkPjxyZWMtbnVtYmVyPjI1NTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlz
PjxrZXkgYXBwPSJFTiIgZGItaWQ9IjVwcndlNXNhMXN6MnNwZWVmd3I1dHgwb3hkdzlzenp4cGFz
ciI+MjU1PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNs
ZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5DYXNhdWx0LCBM
LjwvYXV0aG9yPjxhdXRob3I+U2F2YXJkLCBKLjwvYXV0aG9yPjxhdXRob3I+SXZlcnMsIEguPC9h
dXRob3I+PGF1dGhvcj5TYXZhcmQsIE0uIEguPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0
b3JzPjxhdXRoLWFkZHJlc3M+U2Nob29sIG9mIFBzeWNob2xvZ3ksIFVuaXZlcnNpdGUgTGF2YWws
IFF1ZWJlYywgUXVlYmVjLCBHMVYgMEE2LCBDYW5hZGE7IENlbnRyZSBkZSByZWNoZXJjaGUgZHUg
Q0hVIGRlIFF1ZWJlYyBhbmQgQ2VudHJlIGRlIHJlY2hlcmNoZSBzdXIgbGUgY2FuY2VyLCBVbml2
ZXJzaXRlIExhdmFsLCAxMSBDb3RlIGR1IFBhbGFpcywgUXVlYmVjLCBHMVIgMko2LCBDYW5hZGE7
IENlbnRyZSBob3NwaXRhbGllciB1bml2ZXJzaXRhaXJlIChDSFUpIGRlIFF1ZWJlYywgMTEsIENv
dGUgZHUgUGFsYWlzLCBRdWViZWMsIFF1ZWJlYywgRzFSIDJKNiwgQ2FuYWRhLiYjeEQ7U2Nob29s
IG9mIFBzeWNob2xvZ3ksIFVuaXZlcnNpdGUgTGF2YWwsIFF1ZWJlYywgUXVlYmVjLCBHMVYgMEE2
LCBDYW5hZGE7IENlbnRyZSBkZSByZWNoZXJjaGUgZHUgQ0hVIGRlIFF1ZWJlYyBhbmQgQ2VudHJl
IGRlIHJlY2hlcmNoZSBzdXIgbGUgY2FuY2VyLCBVbml2ZXJzaXRlIExhdmFsLCAxMSBDb3RlIGR1
IFBhbGFpcywgUXVlYmVjLCBHMVIgMko2LCBDYW5hZGEuIEVsZWN0cm9uaWMgYWRkcmVzczogam9z
ZWUuc2F2YXJkQHBzeS51bGF2YWwuY2EuJiN4RDtTY2hvb2wgb2YgUHN5Y2hvbG9neSwgVW5pdmVy
c2l0ZSBMYXZhbCwgUXVlYmVjLCBRdWViZWMsIEcxViAwQTYsIENhbmFkYTsgQ2VudHJlIGRlIHJl
Y2hlcmNoZSBkdSBDSFUgZGUgUXVlYmVjIGFuZCBDZW50cmUgZGUgcmVjaGVyY2hlIHN1ciBsZSBj
YW5jZXIsIFVuaXZlcnNpdGUgTGF2YWwsIDExIENvdGUgZHUgUGFsYWlzLCBRdWViZWMsIEcxUiAy
SjYsIENhbmFkYS4mI3hEO0NlbnRyZSBkZSByZWNoZXJjaGUgZHUgQ0hVIGRlIFF1ZWJlYyBhbmQg
Q2VudHJlIGRlIHJlY2hlcmNoZSBzdXIgbGUgY2FuY2VyLCBVbml2ZXJzaXRlIExhdmFsLCAxMSBD
b3RlIGR1IFBhbGFpcywgUXVlYmVjLCBHMVIgMko2LCBDYW5hZGEuPC9hdXRoLWFkZHJlc3M+PHRp
dGxlcz48dGl0bGU+QSByYW5kb21pemVkLWNvbnRyb2xsZWQgdHJpYWwgb2YgYW4gZWFybHkgbWlu
aW1hbCBjb2duaXRpdmUtYmVoYXZpb3VyYWwgdGhlcmFweSBmb3IgaW5zb21uaWEgY29tb3JiaWQg
d2l0aCBjYW5jZXI8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+QmVoYXYgUmVzIFRoZXI8L3NlY29u
ZGFyeS10aXRsZT48YWx0LXRpdGxlPkJlaGF2aW91ciByZXNlYXJjaCBhbmQgdGhlcmFweTwvYWx0
LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkJlaGF2IFJlcyBUaGVyPC9m
dWxsLXRpdGxlPjxhYmJyLTE+QmVoYXZpb3VyIHJlc2VhcmNoIGFuZCB0aGVyYXB5PC9hYmJyLTE+
PC9wZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5CZWhhdiBSZXMgVGhlcjwv
ZnVsbC10aXRsZT48YWJici0xPkJlaGF2aW91ciByZXNlYXJjaCBhbmQgdGhlcmFweTwvYWJici0x
PjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjQ1LTU0PC9wYWdlcz48dm9sdW1lPjY3PC92b2x1bWU+
PGVkaXRpb24+MjAxNS8wMy8xMDwvZWRpdGlvbj48ZGF0ZXM+PHllYXI+MjAxNTwveWVhcj48cHVi
LWRhdGVzPjxkYXRlPkFwcjwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE4NzMtNjIy
WCAoRWxlY3Ryb25pYykmI3hEOzAwMDUtNzk2NyAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1u
dW0+MjU3NDY3Nzc8L2FjY2Vzc2lvbi1udW0+PHdvcmstdHlwZT5SZXNlYXJjaCBTdXBwb3J0LCBO
b24tVS5TLiBHb3YmYXBvczt0PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0
dHA6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMjU3NDY3Nzc8L3VybD48L3JlbGF0ZWQt
dXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEwMTYvai5icmF0LjIwMTUu
MDIuMDAzPC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48
L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5KYW5zc29uPC9BdXRob3I+PFllYXI+MjAwNTwv
WWVhcj48UmVjTnVtPjI2MzwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+MjYzPC9yZWMtbnVt
YmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0iNXByd2U1c2Exc3oyc3BlZWZ3
cjV0eDBveGR3OXN6enhwYXNyIj4yNjM8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFt
ZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48
YXV0aG9yPkphbnNzb24sIE0uPC9hdXRob3I+PGF1dGhvcj5MaW50b24sIFMuIEouPC9hdXRob3I+
PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+RGVwYXJ0bWVudCBvZiBPY2N1
cGF0aW9uYWwgYW5kIEVudmlyb25tZW50YWwgTWVkaWNpbmUsIE9yZWJybyBNZWRpY2FsIENlbnRl
ciwgUy03MDEgODUgT3JlYnJvLCBTd2VkZW4uPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+
Q29nbml0aXZlLWJlaGF2aW9yYWwgZ3JvdXAgdGhlcmFweSBhcyBhbiBlYXJseSBpbnRlcnZlbnRp
b24gZm9yIGluc29tbmlhOiBhIHJhbmRvbWl6ZWQgY29udHJvbGxlZCB0cmlhbDwvdGl0bGU+PHNl
Y29uZGFyeS10aXRsZT5KIE9jY3VwIFJlaGFiaWw8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxl
PkpvdXJuYWwgb2Ygb2NjdXBhdGlvbmFsIHJlaGFiaWxpdGF0aW9uPC9hbHQtdGl0bGU+PC90aXRs
ZXM+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkpvdXJuYWwgb2YgT2NjdXBhdGlvbmFsIFJl
aGFiaWxpdGF0aW9uPC9mdWxsLXRpdGxlPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjE3Ny05MDwv
cGFnZXM+PHZvbHVtZT4xNTwvdm9sdW1lPjxudW1iZXI+MjwvbnVtYmVyPjxlZGl0aW9uPjIwMDUv
MDQvMjM8L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFkb2xlc2NlbnQ8L2tleXdvcmQ+PGtl
eXdvcmQ+QWR1bHQ8L2tleXdvcmQ+PGtleXdvcmQ+QWdlZDwva2V5d29yZD48a2V5d29yZD5Bbnhp
ZXR5PC9rZXl3b3JkPjxrZXl3b3JkPkF0dGl0dWRlIHRvIEhlYWx0aDwva2V5d29yZD48a2V5d29y
ZD4qQ29nbml0aXZlIFRoZXJhcHk8L2tleXdvcmQ+PGtleXdvcmQ+RGVwcmVzc2lvbjwva2V5d29y
ZD48a2V5d29yZD5GZW1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+Rm9sbG93LVVwIFN0dWRpZXM8L2tl
eXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+PGtl
eXdvcmQ+TWlkZGxlIEFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+KlBhdGllbnQgRWR1Y2F0aW9uIGFz
IFRvcGljPC9rZXl3b3JkPjxrZXl3b3JkPipQc3ljaG90aGVyYXB5LCBHcm91cDwva2V5d29yZD48
a2V5d29yZD5TbGVlcCBJbml0aWF0aW9uIGFuZCBNYWludGVuYW5jZSBEaXNvcmRlcnMvcGh5c2lv
cGF0aG9sb2d5Lyp0aGVyYXB5PC9rZXl3b3JkPjxrZXl3b3JkPlN1cnZleXMgYW5kIFF1ZXN0aW9u
bmFpcmVzPC9rZXl3b3JkPjxrZXl3b3JkPlRlYWNoaW5nIE1hdGVyaWFscy9zdXBwbHkgJmFtcDsg
ZGlzdHJpYnV0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPlRpbWUgRmFjdG9yczwva2V5d29yZD48a2V5
d29yZD5UcmVhdG1lbnQgT3V0Y29tZTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4y
MDA1PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+SnVuPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+
PGlzYm4+MTA1My0wNDg3IChQcmludCkmI3hEOzEwNTMtMDQ4NyAoTGlua2luZyk8L2lzYm4+PGFj
Y2Vzc2lvbi1udW0+MTU4NDQ2NzU8L2FjY2Vzc2lvbi1udW0+PHdvcmstdHlwZT5DbGluaWNhbCBU
cmlhbCYjeEQ7UmFuZG9taXplZCBDb250cm9sbGVkIFRyaWFsJiN4RDtSZXNlYXJjaCBTdXBwb3J0
LCBOb24tVS5TLiBHb3YmYXBvczt0PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJs
Pmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMTU4NDQ2NzU8L3VybD48L3JlbGF0
ZWQtdXJscz48L3VybHM+PGxhbmd1YWdlPmVuZzwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9DaXRlPjxD
aXRlPjxBdXRob3I+Uml0dGVyYmFuZDwvQXV0aG9yPjxZZWFyPjIwMTI8L1llYXI+PFJlY051bT4y
Nzc8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVyPjI3NzwvcmVjLW51bWJlcj48Zm9yZWlnbi1r
ZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9IjVwcndlNXNhMXN6MnNwZWVmd3I1dHgwb3hkdzlzenp4
cGFzciI+Mjc3PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0
aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5SaXR0ZXJi
YW5kLCBMLiBNLjwvYXV0aG9yPjxhdXRob3I+QmFpbGV5LCBFLiBULjwvYXV0aG9yPjxhdXRob3I+
VGhvcm5kaWtlLCBGLiBQLjwvYXV0aG9yPjxhdXRob3I+TG9yZCwgSC4gUi48L2F1dGhvcj48YXV0
aG9yPkZhcnJlbGwtQ2FybmFoYW4sIEwuPC9hdXRob3I+PGF1dGhvcj5CYXVtLCBMLiBELjwvYXV0
aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkRlcGFydG1lbnQgb2Yg
UHN5Y2hpYXRyeSBhbmQgTmV1cm9iZWhhdmlvcmFsIFNjaWVuY2VzLCBVbml2ZXJzaXR5IG9mIFZp
cmdpbmlhIEhlYWx0aCBTeXN0ZW0sIENoYXJsb3R0ZXN2aWxsZSwgVkEgMjI5MDgsIFVTQS4gbGVl
ckB2aXJnaW5pYS5lZHU8L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5Jbml0aWFsIGV2YWx1
YXRpb24gb2YgYW4gSW50ZXJuZXQgaW50ZXJ2ZW50aW9uIHRvIGltcHJvdmUgdGhlIHNsZWVwIG9m
IGNhbmNlciBzdXJ2aXZvcnMgd2l0aCBpbnNvbW5pYTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5Q
c3ljaG9vbmNvbG9neTwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+UHN5Y2hvLW9uY29sb2d5
PC9hbHQtdGl0bGU+PC90aXRsZXM+PHBhZ2VzPjY5NS03MDU8L3BhZ2VzPjx2b2x1bWU+MjE8L3Zv
bHVtZT48bnVtYmVyPjc8L251bWJlcj48ZWRpdGlvbj4yMDExLzA1LzA0PC9lZGl0aW9uPjxrZXl3
b3Jkcz48a2V5d29yZD5BZHVsdDwva2V5d29yZD48a2V5d29yZD5Db2duaXRpdmUgVGhlcmFweS8q
bWV0aG9kczwva2V5d29yZD48a2V5d29yZD5GYXRpZ3VlL3BzeWNob2xvZ3kvdGhlcmFweTwva2V5
d29yZD48a2V5d29yZD5GZW1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+Rm9sbG93LVVwIFN0dWRpZXM8
L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPipJbnRlcm5ldDwva2V5
d29yZD48a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3b3JkPk1pZGRsZSBBZ2VkPC9rZXl3b3Jk
PjxrZXl3b3JkPk5lb3BsYXNtcy8qY29tcGxpY2F0aW9ucy9wc3ljaG9sb2d5Lyp0aGVyYXB5PC9r
ZXl3b3JkPjxrZXl3b3JkPlBhdGllbnQgRWR1Y2F0aW9uIGFzIFRvcGljL21ldGhvZHM8L2tleXdv
cmQ+PGtleXdvcmQ+UXVhbGl0eSBvZiBMaWZlL3BzeWNob2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+
U2V2ZXJpdHkgb2YgSWxsbmVzcyBJbmRleDwva2V5d29yZD48a2V5d29yZD5TbGVlcCBJbml0aWF0
aW9uIGFuZCBNYWludGVuYW5jZSBEaXNvcmRlcnMvKmV0aW9sb2d5L3BzeWNob2xvZ3kvKnRoZXJh
cHk8L2tleXdvcmQ+PGtleXdvcmQ+U3RyZXNzLCBQc3ljaG9sb2dpY2FsPC9rZXl3b3JkPjxrZXl3
b3JkPlN1cnZpdm9ycy8qcHN5Y2hvbG9neTwva2V5d29yZD48a2V5d29yZD5UaGVyYXB5LCBDb21w
dXRlci1Bc3Npc3RlZC8qbWV0aG9kczwva2V5d29yZD48a2V5d29yZD5UcmVhdG1lbnQgT3V0Y29t
ZTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDEyPC95ZWFyPjxwdWItZGF0ZXM+
PGRhdGU+SnVsPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTA5OS0xNjExIChFbGVj
dHJvbmljKSYjeEQ7MTA1Ny05MjQ5IChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4yMTUz
ODY3ODwvYWNjZXNzaW9uLW51bT48d29yay10eXBlPlJhbmRvbWl6ZWQgQ29udHJvbGxlZCBUcmlh
bCYjeEQ7UmVzZWFyY2ggU3VwcG9ydCwgTi5JLkguLCBFeHRyYW11cmFsJiN4RDtSZXNlYXJjaCBT
dXBwb3J0LCBOb24tVS5TLiBHb3YmYXBvczt0PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJs
cz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMjE1Mzg2Nzg8L3VybD48
L3JlbGF0ZWQtdXJscz48L3VybHM+PGN1c3RvbTI+MzQyNDI3MDwvY3VzdG9tMj48ZWxlY3Ryb25p
Yy1yZXNvdXJjZS1udW0+MTAuMTAwMi9wb24uMTk2OTwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+
PGxhbmd1YWdlPmVuZzwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+TGFt
aTwvQXV0aG9yPjxZZWFyPjIwMTY8L1llYXI+PFJlY051bT4yNjY8L1JlY051bT48cmVjb3JkPjxy
ZWMtbnVtYmVyPjI2NjwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGIt
aWQ9IjVwcndlNXNhMXN6MnNwZWVmd3I1dHgwb3hkdzlzenp4cGFzciI+MjY2PC9rZXk+PC9mb3Jl
aWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxj
b250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5MYW1pLCBNLiBKLjwvYXV0aG9yPjxhdXRob3I+
TWFydGluZXosIE0uIFAuPC9hdXRob3I+PGF1dGhvcj5TYW5jaGV6LCBBLiBJLjwvYXV0aG9yPjxh
dXRob3I+TWlybywgRS48L2F1dGhvcj48YXV0aG9yPkRpZW5lciwgRi4gTi48L2F1dGhvcj48YXV0
aG9yPlByYWRvcywgRy48L2F1dGhvcj48YXV0aG9yPkd1em1hbiwgTS4gQS48L2F1dGhvcj48L2F1
dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5EZXBhcnRtZW50IG9mIFBlcnNvbmFs
aXR5LCBBc3Nlc3NtZW50LCBhbmQgUHN5Y2hvbG9naWNhbCBUcmVhdG1lbnQsIEZhY3VsdHkgb2Yg
UHN5Y2hvbG9neSwgVW5pdmVyc2l0eSBvZiBHcmFuYWRhLCBHcmFuYWRhLCBTcGFpbi4mI3hEO01p
bmQsIEJyYWluIGFuZCBCZWhhdmlvciBSZXNlYXJjaCBDZW50ZXIgKENJTUNZQyksIFVuaXZlcnNp
dHkgb2YgR3JhbmFkYSwgR3JhbmFkYSwgU3BhaW4uJiN4RDtJbnRlcm5hbCBNZWRpY2luZSBTZXJ2
aWNlLCBWaXJnZW4gZGUgbGFzIE5pZXZlcyBVbml2ZXJzaXR5IEhvc3BpdGFsLCBhbmQgUmhldW1h
dG9sb2d5IFNlcnZpY2UsIFZpcmdlbiBkZSBsYXMgTmlldmVzIFVuaXZlcnNpdHkgSG9zcGl0YWws
IEdyYW5hZGEsIFNwYWluLjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkdlbmRlciBEaWZm
ZXJlbmNlcyBpbiBQYXRpZW50cyB3aXRoIEZpYnJvbXlhbGdpYSBVbmRlcmdvaW5nIENvZ25pdGl2
ZS1CZWhhdmlvcmFsIFRoZXJhcHkgZm9yIEluc29tbmlhOiBQcmVsaW1pbmFyeSBEYXRhPC90aXRs
ZT48c2Vjb25kYXJ5LXRpdGxlPlBhaW4gUHJhY3Q8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxl
PlBhaW4gcHJhY3RpY2UgOiB0aGUgb2ZmaWNpYWwgam91cm5hbCBvZiBXb3JsZCBJbnN0aXR1dGUg
b2YgUGFpbjwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwYWdlcz5FMjMtMzQ8L3BhZ2VzPjx2b2x1bWU+
MTY8L3ZvbHVtZT48bnVtYmVyPjI8L251bWJlcj48ZWRpdGlvbj4yMDE2LzAyLzA0PC9lZGl0aW9u
PjxkYXRlcz48eWVhcj4yMDE2PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+RmViPC9kYXRlPjwvcHVi
LWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTUzMy0yNTAwIChFbGVjdHJvbmljKSYjeEQ7MTUzMC03MDg1
IChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4yNjg0MTE5ODwvYWNjZXNzaW9uLW51bT48
d29yay10eXBlPlJlc2VhcmNoIFN1cHBvcnQsIE5vbi1VLlMuIEdvdiZhcG9zO3Q8L3dvcmstdHlw
ZT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cDovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1
Ym1lZC8yNjg0MTE5ODwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNv
dXJjZS1udW0+MTAuMTExMS9wYXByLjEyNDExPC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48bGFu
Z3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5Td2Fuc29u
PC9BdXRob3I+PFllYXI+MjAxMzwvWWVhcj48UmVjTnVtPjI0OTwvUmVjTnVtPjxyZWNvcmQ+PHJl
Yy1udW1iZXI+MjQ5PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1p
ZD0iNXByd2U1c2Exc3oyc3BlZWZ3cjV0eDBveGR3OXN6enhwYXNyIj4yNDk8L2tleT48L2ZvcmVp
Z24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNv
bnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPlN3YW5zb24sIEwuIE0uPC9hdXRob3I+PGF1dGhv
cj5GbHlubiwgSC48L2F1dGhvcj48YXV0aG9yPkFkYW1zLU11bmR5LCBKLiBELjwvYXV0aG9yPjxh
dXRob3I+QXJtaXRhZ2UsIFIuPC9hdXRob3I+PGF1dGhvcj5Bcm5lZHQsIEouIFQuPC9hdXRob3I+
PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+RGVwYXJ0bWVudCBvZiBQc3lj
aGlhdHJ5LCBVbml2ZXJzaXR5IG9mIE1pY2hpZ2FuLCBVU0EuIExNU3dhbkBtZWQudW1pY2guZWR1
PC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+QW4gb3BlbiBwaWxvdCBvZiBjb2duaXRpdmUt
YmVoYXZpb3JhbCB0aGVyYXB5IGZvciBpbnNvbW5pYSBpbiB3b21lbiB3aXRoIHBvc3RwYXJ0dW0g
ZGVwcmVzc2lvbjwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5CZWhhdiBTbGVlcCBNZWQ8L3NlY29u
ZGFyeS10aXRsZT48YWx0LXRpdGxlPkJlaGF2aW9yYWwgc2xlZXAgbWVkaWNpbmU8L2FsdC10aXRs
ZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5CZWhhdiBTbGVlcCBNZWQ8L2Z1bGwt
dGl0bGU+PGFiYnItMT5CZWhhdmlvcmFsIHNsZWVwIG1lZGljaW5lPC9hYmJyLTE+PC9wZXJpb2Rp
Y2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5CZWhhdiBTbGVlcCBNZWQ8L2Z1bGwtdGl0
bGU+PGFiYnItMT5CZWhhdmlvcmFsIHNsZWVwIG1lZGljaW5lPC9hYmJyLTE+PC9hbHQtcGVyaW9k
aWNhbD48cGFnZXM+Mjk3LTMwNzwvcGFnZXM+PHZvbHVtZT4xMTwvdm9sdW1lPjxudW1iZXI+NDwv
bnVtYmVyPjxlZGl0aW9uPjIwMTIvMTIvMTI8L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFk
dWx0PC9rZXl3b3JkPjxrZXl3b3JkPipBZmZlY3Q8L2tleXdvcmQ+PGtleXdvcmQ+KkNvZ25pdGl2
ZSBUaGVyYXB5PC9rZXl3b3JkPjxrZXl3b3JkPkRlcHJlc3Npb24sIFBvc3RwYXJ0dW0vKmNvbXBs
aWNhdGlvbnM8L2tleXdvcmQ+PGtleXdvcmQ+RmF0aWd1ZS9jb21wbGljYXRpb25zL3BzeWNob2xv
Z3k8L2tleXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5
d29yZD48a2V5d29yZD5QaWxvdCBQcm9qZWN0czwva2V5d29yZD48a2V5d29yZD5TZXZlcml0eSBv
ZiBJbGxuZXNzIEluZGV4PC9rZXl3b3JkPjxrZXl3b3JkPipTbGVlcDwva2V5d29yZD48a2V5d29y
ZD5TbGVlcCBJbml0aWF0aW9uIGFuZCBNYWludGVuYW5jZSBEaXNvcmRlcnMvY29tcGxpY2F0aW9u
cy9wc3ljaG9sb2d5Lyp0aGVyYXB5PC9rZXl3b3JkPjxrZXl3b3JkPlRyZWF0bWVudCBPdXRjb21l
PC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTM8L3llYXI+PC9kYXRlcz48aXNi
bj4xNTQwLTIwMTAgKEVsZWN0cm9uaWMpJiN4RDsxNTQwLTIwMDIgKExpbmtpbmcpPC9pc2JuPjxh
Y2Nlc3Npb24tbnVtPjIzMjE2MzczPC9hY2Nlc3Npb24tbnVtPjx3b3JrLXR5cGU+UmVzZWFyY2gg
U3VwcG9ydCwgTm9uLVUuUy4gR292JmFwb3M7dDwvd29yay10eXBlPjx1cmxzPjxyZWxhdGVkLXVy
bHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzIzMjE2MzczPC91cmw+
PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMDgwLzE1
NDAyMDAyLjIwMTIuNjgzOTAyPC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48bGFuZ3VhZ2U+ZW5n
PC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5Ub21mb2hyLU1hZHNlbjwv
QXV0aG9yPjxZZWFyPjIwMTY8L1llYXI+PFJlY051bT4yODc8L1JlY051bT48cmVjb3JkPjxyZWMt
bnVtYmVyPjI4NzwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9
IjVwcndlNXNhMXN6MnNwZWVmd3I1dHgwb3hkdzlzenp4cGFzciI+Mjg3PC9rZXk+PC9mb3JlaWdu
LWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250
cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5Ub21mb2hyLU1hZHNlbiwgTC4gTS48L2F1dGhvcj48
YXV0aG9yPkNsYXlib3JuZSwgWi4gTS48L2F1dGhvcj48YXV0aG9yPlJvdWxlYXUsIEMuIFIuPC9h
dXRob3I+PGF1dGhvcj5DYW1wYmVsbCwgVC4gUy48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmli
dXRvcnM+PGF1dGgtYWRkcmVzcz5hIERlcGFydG1lbnQgb2YgUHN5Y2hvbG9neSAsIFVuaXZlcnNp
dHkgb2YgQ2FsZ2FyeSAsIENhbGdhcnkgLCBBbGJlcnRhICwgQ2FuYWRhLiYjeEQ7YiBBbGJlcnRh
IENoaWxkcmVuJmFwb3M7cyBIb3NwaXRhbCBSZXNlYXJjaCBJbnN0aXR1dGUgZm9yIENoaWxkIGFu
ZCBNYXRlcm5hbCBIZWFsdGggLCBDYWxnYXJ5ICwgQWxiZXJ0YSAsIENhbmFkYS4mI3hEO2MgRGVw
YXJ0bWVudCBvZiBQZWRpYXRyaWNzICwgQWxiZXJ0YSBDaGlsZHJlbiZhcG9zO3MgSG9zcGl0YWwg
LCBDYWxnYXJ5ICwgQWxiZXJ0YSAsIENhbmFkYS48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRs
ZT5TbGVlcGluZyBmb3IgVHdvOiBBbiBPcGVuLVBpbG90IFN0dWR5IG9mIENvZ25pdGl2ZSBCZWhh
dmlvcmFsIFRoZXJhcHkgZm9yIEluc29tbmlhIGluIFByZWduYW5jeTwvdGl0bGU+PHNlY29uZGFy
eS10aXRsZT5CZWhhdiBTbGVlcCBNZWQ8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxlPkJlaGF2
aW9yYWwgc2xlZXAgbWVkaWNpbmU8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVs
bC10aXRsZT5CZWhhdiBTbGVlcCBNZWQ8L2Z1bGwtdGl0bGU+PGFiYnItMT5CZWhhdmlvcmFsIHNs
ZWVwIG1lZGljaW5lPC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10
aXRsZT5CZWhhdiBTbGVlcCBNZWQ8L2Z1bGwtdGl0bGU+PGFiYnItMT5CZWhhdmlvcmFsIHNsZWVw
IG1lZGljaW5lPC9hYmJyLTE+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+MS0xNzwvcGFnZXM+PGVk
aXRpb24+MjAxNi8wNC8yOTwvZWRpdGlvbj48ZGF0ZXM+PHllYXI+MjAxNjwveWVhcj48cHViLWRh
dGVzPjxkYXRlPkFwciAyODwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE1NDAtMjAx
MCAoRWxlY3Ryb25pYykmI3hEOzE1NDAtMjAwMiAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1u
dW0+MjcxMjQ0MDU8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6
Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMjcxMjQ0MDU8L3VybD48L3JlbGF0ZWQtdXJs
cz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEwODAvMTU0MDIwMDIuMjAxNi4x
MTQxNzY5PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48bGFuZ3VhZ2U+RW5nPC9sYW5ndWFnZT48
L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPn==
ADDIN EN.CITE.DATA (47, 48, 52, 58-60), there appears to be preliminary evidence for a small to moderate size effect of CBT-I on subjective measures of cognitive functioning. The impact of CBT-I on objective measures of cognitive functioning is more equivocal, predominantly due to lack of research. It is clear that further adequately powered RCTs, utilising both subjective and objective measures of cognitive performance are required, before firm conclusions can be drawn.In terms of maintenance of the effects, there were nine studies that conducted a follow-up assessment of cognitive functioning, three to six months following the intervention. The majority of these studies found no significant difference between post-intervention and follow-up scores, indicating that where there were initial gains, these tended to be maintained. In one study, performance on the vigilance test worsened between baseline and post-intervention but returned to baseline levels between post-intervention and follow-up PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5PbXZpazwvQXV0aG9yPjxZZWFyPjIwMDg8L1llYXI+PFJl
Y051bT4yNzI8L1JlY051bT48RGlzcGxheVRleHQ+KDUxKTwvRGlzcGxheVRleHQ+PHJlY29yZD48
cmVjLW51bWJlcj4yNzI8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRi
LWlkPSI1cHJ3ZTVzYTFzejJzcGVlZndyNXR4MG94ZHc5c3p6eHBhc3IiPjI3Mjwva2V5PjwvZm9y
ZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48
Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+T212aWssIFMuPC9hdXRob3I+PGF1dGhvcj5T
aXZlcnRzZW4sIEIuPC9hdXRob3I+PGF1dGhvcj5QYWxsZXNlbiwgUy48L2F1dGhvcj48YXV0aG9y
PkJqb3J2YXRuLCBCLjwvYXV0aG9yPjxhdXRob3I+SGF2aWssIE8uIEUuPC9hdXRob3I+PGF1dGhv
cj5Ob3JkaHVzLCBJLiBILjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1h
ZGRyZXNzPkRlcGFydG1lbnQgb2YgQ2xpbmljYWwgUHN5Y2hvbG9neSwgVW5pdmVyc2l0eSBvZiBC
ZXJnZW4sIEJlcmdlbiwgTm9yd2F5LiBzaXJpLm9tdmlrQHBzeWtwLnVpYi5ubzwvYXV0aC1hZGRy
ZXNzPjx0aXRsZXM+PHRpdGxlPkRheXRpbWUgZnVuY3Rpb25pbmcgaW4gb2xkZXIgcGF0aWVudHMg
c3VmZmVyaW5nIGZyb20gY2hyb25pYyBpbnNvbW5pYTogdHJlYXRtZW50IG91dGNvbWUgaW4gYSBy
YW5kb21pemVkIGNvbnRyb2xsZWQgdHJpYWwgY29tcGFyaW5nIENCVCB3aXRoIFpvcGljbG9uZTwv
dGl0bGU+PHNlY29uZGFyeS10aXRsZT5CZWhhdiBSZXMgVGhlcjwvc2Vjb25kYXJ5LXRpdGxlPjxh
bHQtdGl0bGU+QmVoYXZpb3VyIHJlc2VhcmNoIGFuZCB0aGVyYXB5PC9hbHQtdGl0bGU+PC90aXRs
ZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+QmVoYXYgUmVzIFRoZXI8L2Z1bGwtdGl0bGU+PGFi
YnItMT5CZWhhdmlvdXIgcmVzZWFyY2ggYW5kIHRoZXJhcHk8L2FiYnItMT48L3BlcmlvZGljYWw+
PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkJlaGF2IFJlcyBUaGVyPC9mdWxsLXRpdGxlPjxh
YmJyLTE+QmVoYXZpb3VyIHJlc2VhcmNoIGFuZCB0aGVyYXB5PC9hYmJyLTE+PC9hbHQtcGVyaW9k
aWNhbD48cGFnZXM+NjIzLTQxPC9wYWdlcz48dm9sdW1lPjQ2PC92b2x1bWU+PG51bWJlcj41PC9u
dW1iZXI+PGVkaXRpb24+MjAwOC8wNC8xODwvZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QWdl
ZDwva2V5d29yZD48a2V5d29yZD5BemFiaWN5Y2xvIENvbXBvdW5kcy8qdGhlcmFwZXV0aWMgdXNl
PC9rZXl3b3JkPjxrZXl3b3JkPipDb2duaXRpdmUgVGhlcmFweTwva2V5d29yZD48a2V5d29yZD5G
ZW1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPkh5cG5vdGlj
cyBhbmQgU2VkYXRpdmVzLyp0aGVyYXBldXRpYyB1c2U8L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwv
a2V5d29yZD48a2V5d29yZD5NaWRkbGUgQWdlZDwva2V5d29yZD48a2V5d29yZD5QaXBlcmF6aW5l
cy8qdGhlcmFwZXV0aWMgdXNlPC9rZXl3b3JkPjxrZXl3b3JkPlBzeWNoaWF0cmljIFN0YXR1cyBS
YXRpbmcgU2NhbGVzPC9rZXl3b3JkPjxrZXl3b3JkPlF1YWxpdHkgb2YgTGlmZTwva2V5d29yZD48
a2V5d29yZD5TbGVlcCBJbml0aWF0aW9uIGFuZCBNYWludGVuYW5jZSBEaXNvcmRlcnMvKnRoZXJh
cHk8L2tleXdvcmQ+PGtleXdvcmQ+VHJlYXRtZW50IE91dGNvbWU8L2tleXdvcmQ+PC9rZXl3b3Jk
cz48ZGF0ZXM+PHllYXI+MjAwODwveWVhcj48cHViLWRhdGVzPjxkYXRlPk1heTwvZGF0ZT48L3B1
Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjAwMDUtNzk2NyAoUHJpbnQpJiN4RDswMDA1LTc5NjcgKExp
bmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjE4NDE3MDk5PC9hY2Nlc3Npb24tbnVtPjx3b3Jr
LXR5cGU+Q29tcGFyYXRpdmUgU3R1ZHkmI3hEO1JhbmRvbWl6ZWQgQ29udHJvbGxlZCBUcmlhbCYj
eEQ7UmVzZWFyY2ggU3VwcG9ydCwgTm9uLVUuUy4gR292JmFwb3M7dDwvd29yay10eXBlPjx1cmxz
PjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzE4
NDE3MDk5PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51
bT4xMC4xMDE2L2ouYnJhdC4yMDA4LjAyLjAxMzwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PGxh
bmd1YWdlPmVuZzwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT5=
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5PbXZpazwvQXV0aG9yPjxZZWFyPjIwMDg8L1llYXI+PFJl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=
ADDIN EN.CITE.DATA (51). This may be related to the sleep restriction component of the intervention, which has been associated with increased daytime sleepiness and impairments in vigilance during the acute phase of implementation PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LeWxlPC9BdXRob3I+PFllYXI+MjAxNDwvWWVhcj48UmVj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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LeWxlPC9BdXRob3I+PFllYXI+MjAxNDwvWWVhcj48UmVj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ADDIN EN.CITE.DATA (75, 77). There is evidence that improvements in sleep parameters following CBT-I evolve over time PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Pa2FqaW1hPC9BdXRob3I+PFllYXI+MjAxMTwvWWVhcj48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 EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Pa2FqaW1hPC9BdXRob3I+PFllYXI+MjAxMTwvWWVhcj48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 EN.CITE.DATA (78) and therefore it is possible that improvements in cognitive performance also take time to be manifest. Thus the timing of assessments is an important consideration for future studies, especially where sleep restriction is part of the treatment. Study quality and sources of biasThe risk of bias from inadequate control and lack of blinding in the included studies is high. Although double-blinded placebo controlled studies are difficult to implement when evaluating psychological interventions, a sham insomnia treatment (known as BPT) has been developed ADDIN EN.CITE <EndNote><Cite><Author>Edinger</Author><Year>2001</Year><RecNum>491</RecNum><DisplayText>(79)</DisplayText><record><rec-number>491</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr">491</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Edinger, J. D.</author><author>Wohlgemuth, W. K.</author><author>Radtke, R. A.</author><author>Marsh, G. R.</author><author>Quillian, R. E.</author></authors></contributors><auth-address>Psychology Service (116B), VA Medical Center, 508 Fulton St, Durham, NC 27705, USA. jack.edinger@duke.edu</auth-address><titles><title>Cognitive behavioral therapy for treatment of chronic primary insomnia: a randomized controlled trial</title><secondary-title>JAMA</secondary-title><alt-title>Jama</alt-title></titles><periodical><full-title>JAMA</full-title><abbr-1>Jama</abbr-1></periodical><alt-periodical><full-title>JAMA</full-title><abbr-1>Jama</abbr-1></alt-periodical><pages>1856-64</pages><volume>285</volume><number>14</number><keywords><keyword>Adult</keyword><keyword>Aged</keyword><keyword>*Cognitive Therapy</keyword><keyword>Double-Blind Method</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Polysomnography</keyword><keyword>Relaxation Therapy</keyword><keyword>Sleep Initiation and Maintenance Disorders/*therapy</keyword><keyword>Surveys and Questionnaires</keyword></keywords><dates><year>2001</year><pub-dates><date>Apr 11</date></pub-dates></dates><isbn>0098-7484 (Print)
0098-7484 (Linking)</isbn><accession-num>11308399</accession-num><urls><related-urls><url>;(79). Indeed, BPT was utilised as a control in two of the included studies PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NYXR0aGV3czwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+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==
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NYXR0aGV3czwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+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==
ADDIN EN.CITE.DATA (45, 49). However, the majority of studies in this review used inactive control conditions and participants were not blind to group assignment. Therefore, the specific effects of CBT-I cannot be separated from non-specific effects, such as therapist attention and participant expectation of benefit. The issue of expectancy may be particularly relevant when assessing cognitive functioning, since expectancy effects have been shown to exert a strong influence on objective measures PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Pa2VuPC9BdXRob3I+PFllYXI+MjAwODwvWWVhcj48UmVj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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Pa2VuPC9BdXRob3I+PFllYXI+MjAwODwvWWVhcj48UmVj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ADDIN EN.CITE.DATA (80) and subjective perceptions of cognitive performance ADDIN EN.CITE <EndNote><Cite><Author>Schwarz</Author><Year>2015</Year><RecNum>497</RecNum><DisplayText>(81)</DisplayText><record><rec-number>497</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr">497</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Schwarz, K. A.</author><author>Buchel, C.</author></authors></contributors><auth-address>Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.</auth-address><titles><title>Cognition and the Placebo Effect--Dissociating Subjective Perception and Actual Performance</title><secondary-title>PLoS One</secondary-title><alt-title>PloS one</alt-title></titles><periodical><full-title>PLoS One</full-title><abbr-1>PloS one</abbr-1></periodical><alt-periodical><full-title>PLoS One</full-title><abbr-1>PloS one</abbr-1></alt-periodical><pages>e0130492</pages><volume>10</volume><number>7</number><keywords><keyword>Adult</keyword><keyword>Brain/drug effects/physiology</keyword><keyword>Central Nervous System Stimulants/pharmacology</keyword><keyword>Cognition/drug effects/*physiology</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Nocebo Effect</keyword><keyword>Nootropic Agents/pharmacology</keyword><keyword>Perception/drug effects/*physiology</keyword><keyword>Placebo Effect</keyword><keyword>Psychomotor Performance/drug effects/*physiology</keyword><keyword>Young Adult</keyword></keywords><dates><year>2015</year></dates><isbn>1932-6203 (Electronic)
1932-6203 (Linking)</isbn><accession-num>26148009</accession-num><urls><related-urls><url>;(81). There were five uncontrolled trials and one case-series included within this review. Three of these studies reported effect sizes, all of which were large effects. Meta-analyses of outcomes following psychological interventions commonly observe that uncontrolled studies report larger effects than RCTs PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CdXRsZXI8L0F1dGhvcj48WWVhcj4yMDA2PC9ZZWFyPjxS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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CdXRsZXI8L0F1dGhvcj48WWVhcj4yMDA2PC9ZZWFyPjxS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ADDIN EN.CITE.DATA (82, 83). This is likely due to biases that result from issues such as regression to the mean. Due to the high risk of bias, we gave less weight to results from the uncontrolled trials and case-series, when considering the evidence in this review. Nevertheless, the evidence from uncontrolled trials largely supports data from the RCTs, indicating positive effects of CBT-I on self-report measures of cognitive functioning. Putative MechanismsIf CBT-I does lead to improvements in cognition, it will be important to discover the mechanism through which this occurs. There is some evidence that individuals with insomnia show impairments on complex rather than simple tasks and this is thought to result from greater dependence of complex tasks on functioning of the prefrontal cortex ADDIN EN.CITE <EndNote><Cite><Author>Fortier-Brochu</Author><Year>2012</Year><RecNum>172</RecNum><DisplayText>(13)</DisplayText><record><rec-number>172</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr">172</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Fortier-Brochu, E.</author><author>Beaulieu-Bonneau, S.</author><author>Ivers, H.</author><author>Morin, C. M.</author></authors></contributors><auth-address>Ecole de Psychologie, Universite Laval, Quebec, Canada. emilie.fortier-brochu.1@ulaval.ca</auth-address><titles><title>Insomnia and daytime cognitive performance: a meta-analysis</title><secondary-title>Sleep Med Rev</secondary-title><alt-title>Sleep medicine reviews</alt-title></titles><periodical><full-title>Sleep Med Rev</full-title><abbr-1>Sleep medicine reviews</abbr-1></periodical><alt-periodical><full-title>Sleep Med Rev</full-title><abbr-1>Sleep medicine reviews</abbr-1></alt-periodical><pages>83-94</pages><volume>16</volume><number>1</number><edition>2011/06/04</edition><keywords><keyword>Adult</keyword><keyword>*Cognition</keyword><keyword>Cognition Disorders/etiology</keyword><keyword>Humans</keyword><keyword>Neuropsychological Tests</keyword><keyword>Psychomotor Performance</keyword><keyword>Sleep Initiation and Maintenance Disorders/complications/*psychology</keyword></keywords><dates><year>2012</year><pub-dates><date>Feb</date></pub-dates></dates><isbn>1532-2955 (Electronic)
1087-0792 (Linking)</isbn><accession-num>21636297</accession-num><label>*</label><work-type>Meta-Analysis
Research Support, Non-U.S. Gov't</work-type><urls><related-urls><url>;(13), which may be compromised in insomnia ADDIN EN.CITE <EndNote><Cite><Author>Kay</Author><Year>2017</Year><RecNum>689</RecNum><DisplayText>(84)</DisplayText><record><rec-number>689</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr">689</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Kay, D. B.</author><author>Buysse, D. J.</author></authors></contributors><auth-address>Department of Psychology, Brigham Young University, Provo, UT 84604, USA. daniel_kay@byu.edu.
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA. buyssedj@upmc.edu.</auth-address><titles><title>Hyperarousal and Beyond: New Insights to the Pathophysiology of Insomnia Disorder through Functional Neuroimaging Studies</title><secondary-title>Brain Sci</secondary-title><alt-title>Brain sciences</alt-title></titles><volume>7</volume><number>3</number><edition>2017/03/01</edition><dates><year>2017</year><pub-dates><date>Feb 23</date></pub-dates></dates><isbn>2076-3425 (Linking)</isbn><accession-num>28241468</accession-num><work-type>Review</work-type><urls><related-urls><url>;(84). Hypo-activation of the prefrontal cortex during performance of a category fluency task in individuals with primary insomnia compared to controls has been reported and this hypo-activation was attenuated following sleep therapy (which comprised CBT-I, bright light therapy and body temperature manipulations), with concomitant improvements in phonemic fluency PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BbHRlbmE8L0F1dGhvcj48WWVhcj4yMDA4PC9ZZWFyPjxS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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5BbHRlbmE8L0F1dGhvcj48WWVhcj4yMDA4PC9ZZWFyPjxS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ADDIN EN.CITE.DATA (85). The study by Wilckens et al. ADDIN EN.CITE <EndNote><Cite><Author>Wilckens</Author><Year>2016</Year><RecNum>288</RecNum><DisplayText>(55)</DisplayText><record><rec-number>288</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr">288</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Wilckens, K. A.</author><author>Hall, M. H.</author><author>Nebes, R. D.</author><author>Monk, T. H.</author><author>Buysse, D. J.</author></authors></contributors><auth-address>a Department of Psychiatry , University of Pittsburgh School of Medicine , USA.</auth-address><titles><title>Changes in Cognitive Performance Are Associated with Changes in Sleep in Older Adults With Insomnia</title><secondary-title>Behav Sleep Med</secondary-title><alt-title>Behavioral sleep medicine</alt-title></titles><periodical><full-title>Behav Sleep Med</full-title><abbr-1>Behavioral sleep medicine</abbr-1></periodical><alt-periodical><full-title>Behav Sleep Med</full-title><abbr-1>Behavioral sleep medicine</abbr-1></alt-periodical><pages>295-310</pages><volume>14</volume><number>3</number><edition>2015/09/01</edition><dates><year>2016</year><pub-dates><date>May-Jun</date></pub-dates></dates><isbn>1540-2010 (Electronic)
1540-2002 (Linking)</isbn><accession-num>26322904</accession-num><urls><related-urls><url>;(55) found that changes in electroencephalogram (EEG) spectral power (increased delta and reduce sigma activity) were associated with better executive functioning in older adults, although this was not moderated by the BBTI intervention. One proposal is that delta power during non-rapid eye movement sleep reflects enhanced connectivity within cortical networks and preferentially benefits brain regions such as the prefrontal cortex. On the basis of these findings, one hypothesis which deserves further investigation is that improvements in sleep continuity and normalisation of sleep architecture, leads to enhanced functioning of the prefrontal cortex and, by extension, performance on tasks that recruit this brain region PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5XaWxja2VuczwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5XaWxja2VuczwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+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ADDIN EN.CITE.DATA (86). Of note, a more recent, uncontrolled study by Wilckens and colleagues ADDIN EN.CITE <EndNote><Cite><Author>Wilckens</Author><Year>2017</Year><RecNum>691</RecNum><DisplayText>(87)</DisplayText><record><rec-number>691</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr">691</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Wilckens, K. A.</author><author>Hall, M. H.</author><author>Erickson, K. I.</author><author>Germain, A.</author><author>Nimgaonkar, V. L.</author><author>Monk, T. H.</author><author>Buysse, D. J.</author></authors></contributors><auth-address>Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O'Hara Street, Pittsburgh, PA 15213, USA. Electronic address: wilckenska@upmc.edu.
Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O'Hara Street, Pittsburgh, PA 15213, USA.
Department of Psychology, University of Pittsburgh, 210 South Bouquet Street, Pittsburgh, PA 15260, USA.</auth-address><titles><title>Task switching in older adults with and without insomnia</title><secondary-title>Sleep Med</secondary-title><alt-title>Sleep medicine</alt-title></titles><periodical><full-title>Sleep Med</full-title><abbr-1>Sleep medicine</abbr-1></periodical><alt-periodical><full-title>Sleep Med</full-title><abbr-1>Sleep medicine</abbr-1></alt-periodical><pages>113-120</pages><volume>30</volume><edition>2017/02/22</edition><dates><year>2017</year><pub-dates><date>Feb</date></pub-dates></dates><isbn>1878-5506 (Electronic)
1389-9457 (Linking)</isbn><accession-num>28215233</accession-num><urls><related-urls><url>;(87) observed improvements in task-switching performance, pre-to-post CBT-I, in older adults with insomnia. These improvements were associated with reductions in WASO, however there was no association with whole night delta power. Controlled studies, employing both standard polysomnography and high-density EEG protocols PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5SaWVkbmVyPC9BdXRob3I+PFllYXI+MjAxNjwvWWVhcj48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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5SaWVkbmVyPC9BdXRob3I+PFllYXI+MjAxNjwvWWVhcj48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ADDIN EN.CITE.DATA (88) will help to define a) how CBT-I modifies sleep macro and micro-structure (including the temporospatial dynamics of delta power); and b) whether such changes mediate improvement in cognitive performance.Anxiety and low mood, which are often present in insomnia (particularly comorbid insomnia), have also been associated with cognitive impairment ADDIN EN.CITE <EndNote><Cite><Author>Lezak</Author><Year>2004</Year><RecNum>225</RecNum><DisplayText>(42)</DisplayText><record><rec-number>225</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr">225</key></foreign-keys><ref-type name="Book">6</ref-type><contributors><authors><author>Lezak, Muriel Deutsch</author><author>Howieson, Diane B.</author><author>Loring, David W.</author></authors></contributors><titles><title>Neuropsychological assessment</title></titles><edition>4th ed. / Muriel D. Lezak, Diane B. Howieson, David W. Loring with H. Julia Hannay and Jill S. Fischer.</edition><keywords><keyword>Neuropsychological tests.</keyword></keywords><dates><year>2004</year></dates><pub-location>Oxford</pub-location><publisher>Oxford University Press</publisher><isbn>0195111214 : ?59.50</isbn><call-num>616.80475 22
British Library HMNTS YC.2016.b.866
British Library DSC m04/29607</call-num><urls></urls></record></Cite></EndNote>(42). There is evidence that CBT-I leads to improvements in these variables PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TYXZhcmQ8L0F1dGhvcj48WWVhcj4yMDA1PC9ZZWFyPjxS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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TYXZhcmQ8L0F1dGhvcj48WWVhcj4yMDA1PC9ZZWFyPjxS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ADDIN EN.CITE.DATA (89-92) and therefore, in addition to investigating the potential mediating role of various sleep parameters, future studies should also examine the contribution of changes in secondary psychological variables. Measures of cognitive functioningDiscordance between self-report measures of cognitive functioning and performance on neuropsychological and cognitive tests has been demonstrated in individuals with primary insomnia ADDIN EN.CITE <EndNote><Cite><Author>Orff</Author><Year>2007</Year><RecNum>562</RecNum><DisplayText>(93)</DisplayText><record><rec-number>562</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr">562</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Orff, H. J.</author><author>Drummond, S. P.</author><author>Nowakowski, S.</author><author>Perils, M. L.</author></authors></contributors><auth-address>Joint Doctoral Program in Clinical Psychology, San Diego State University and University of California, San Diego, CA, USA.</auth-address><titles><title>Discrepancy between subjective symptomatology and objective neuropsychological performance in insomnia</title><secondary-title>Sleep</secondary-title><alt-title>Sleep</alt-title></titles><periodical><full-title>Sleep</full-title><abbr-1>Sleep</abbr-1></periodical><alt-periodical><full-title>Sleep</full-title><abbr-1>Sleep</abbr-1></alt-periodical><pages>1205-11</pages><volume>30</volume><number>9</number><keywords><keyword>Adult</keyword><keyword>Cognition</keyword><keyword>Cognition Disorders/diagnosis/*etiology</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Memory</keyword><keyword>Middle Aged</keyword><keyword>*Neuropsychological Tests</keyword><keyword>Perception</keyword><keyword>Polysomnography</keyword><keyword>Psychomotor Performance</keyword><keyword>Reaction Time</keyword><keyword>Sleep Initiation and Maintenance Disorders/*complications</keyword><keyword>Task Performance and Analysis</keyword></keywords><dates><year>2007</year><pub-dates><date>Sep</date></pub-dates></dates><isbn>0161-8105 (Print)
0161-8105 (Linking)</isbn><accession-num>17910392</accession-num><urls><related-urls><url>;(93). Specifically, self-report measures tend to show higher levels of impairment than is found using objective assessment. This discordance is thought to be driven by selective attention to the daytime consequences of insomnia, a phenomenon which is proposed to contribute to the maintenance of the disorder ADDIN EN.CITE <EndNote><Cite><Author>Harvey</Author><Year>2002</Year><RecNum>570</RecNum><DisplayText>(94)</DisplayText><record><rec-number>570</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr">570</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Harvey, A. G.</author></authors></contributors><auth-address>Department of Experimental Psychology, University of Oxford, UK. allison.harvey@psy.ox.ac.uk</auth-address><titles><title>A cognitive model of insomnia</title><secondary-title>Behav Res Ther</secondary-title><alt-title>Behaviour research and therapy</alt-title></titles><periodical><full-title>Behav Res Ther</full-title><abbr-1>Behaviour research and therapy</abbr-1></periodical><alt-periodical><full-title>Behav Res Ther</full-title><abbr-1>Behaviour research and therapy</abbr-1></alt-periodical><pages>869-93</pages><volume>40</volume><number>8</number><keywords><keyword>Circadian Rhythm/physiology</keyword><keyword>Cognition Disorders/*etiology</keyword><keyword>Humans</keyword><keyword>Neuropsychological Tests</keyword><keyword>*Psychological Theory</keyword><keyword>Sleep Initiation and Maintenance Disorders/*complications</keyword></keywords><dates><year>2002</year><pub-dates><date>Aug</date></pub-dates></dates><isbn>0005-7967 (Print)
0005-7967 (Linking)</isbn><accession-num>12186352</accession-num><urls><related-urls><url>;(94). It is possible that CBT-I impacts on subjective and objective measures differentially, for example it may alter perceptions of impairment without impacting on objective performance. In addition, it is possible that there are different mechanisms through which CBT-I impacts on subjective and objective cognition. We were not able to examine this in the current review because there were no studies that investigated cognitive functioning using both subjective and objective measures. Moreover, it was not possible to compare the effects of CBT-I on subjective and objective measures across studies, due to heterogeneity. Future studies should consider the inclusion of both subjective and objective assessments of cognitive function to enable such a comparison.In spite of guidelines espousing the importance of investigating the daytime correlates of insomnia, there are no specific cognitive performance measures or self-report questionnaires that are recommended for routine use in insomnia samples ADDIN EN.CITE <EndNote><Cite><Author>Buysse</Author><Year>2006</Year><RecNum>480</RecNum><DisplayText>(95)</DisplayText><record><rec-number>480</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr">480</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Buysse, D. J.</author><author>Ancoli-Israel, S.</author><author>Edinger, J. D.</author><author>Lichstein, K. L.</author><author>Morin, C. M.</author></authors></contributors><auth-address>Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA. buyssedj@upmc.edu</auth-address><titles><title>Recommendations for a standard research assessment of insomnia</title><secondary-title>Sleep</secondary-title><alt-title>Sleep</alt-title></titles><periodical><full-title>Sleep</full-title><abbr-1>Sleep</abbr-1></periodical><alt-periodical><full-title>Sleep</full-title><abbr-1>Sleep</abbr-1></alt-periodical><pages>1155-73</pages><volume>29</volume><number>9</number><keywords><keyword>Anxiety/diagnosis/epidemiology</keyword><keyword>Depression/diagnosis/epidemiology</keyword><keyword>Disorders of Excessive Somnolence/epidemiology</keyword><keyword>Fatigue/epidemiology</keyword><keyword>*Guidelines as Topic</keyword><keyword>Health Status</keyword><keyword>Humans</keyword><keyword>Polysomnography</keyword><keyword>Psychomotor Disorders/diagnosis/epidemiology</keyword><keyword>Quality of Life/psychology</keyword><keyword>Sleep Initiation and Maintenance</keyword><keyword>Disorders/*diagnosis/epidemiology/physiopathology</keyword><keyword>Surveys and Questionnaires</keyword></keywords><dates><year>2006</year><pub-dates><date>Sep</date></pub-dates></dates><isbn>0161-8105 (Print)
0161-8105 (Linking)</isbn><accession-num>17040003</accession-num><urls><related-urls><url>;(95). A meta-analysis ADDIN EN.CITE <EndNote><Cite><Author>Fortier-Brochu</Author><Year>2012</Year><RecNum>172</RecNum><DisplayText>(13)</DisplayText><record><rec-number>172</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr">172</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Fortier-Brochu, E.</author><author>Beaulieu-Bonneau, S.</author><author>Ivers, H.</author><author>Morin, C. M.</author></authors></contributors><auth-address>Ecole de Psychologie, Universite Laval, Quebec, Canada. emilie.fortier-brochu.1@ulaval.ca</auth-address><titles><title>Insomnia and daytime cognitive performance: a meta-analysis</title><secondary-title>Sleep Med Rev</secondary-title><alt-title>Sleep medicine reviews</alt-title></titles><periodical><full-title>Sleep Med Rev</full-title><abbr-1>Sleep medicine reviews</abbr-1></periodical><alt-periodical><full-title>Sleep Med Rev</full-title><abbr-1>Sleep medicine reviews</abbr-1></alt-periodical><pages>83-94</pages><volume>16</volume><number>1</number><edition>2011/06/04</edition><keywords><keyword>Adult</keyword><keyword>*Cognition</keyword><keyword>Cognition Disorders/etiology</keyword><keyword>Humans</keyword><keyword>Neuropsychological Tests</keyword><keyword>Psychomotor Performance</keyword><keyword>Sleep Initiation and Maintenance Disorders/complications/*psychology</keyword></keywords><dates><year>2012</year><pub-dates><date>Feb</date></pub-dates></dates><isbn>1532-2955 (Electronic)
1087-0792 (Linking)</isbn><accession-num>21636297</accession-num><label>*</label><work-type>Meta-Analysis
Research Support, Non-U.S. Gov't</work-type><urls><related-urls><url>;(13) concluded that insomnia is associated with impairments on tasks assessing episodic memory, problem-solving and working memory. A caveat to these findings is that for some of the cognitive domains examined, there were few studies available and therefore low statistical power may explain lack of group differences. Accordingly, assessment of a broad range of cognitive domains is encouraged. In this review, we did not uncover any patterns across studies in terms of cognitive domains that appear to be more sensitive to the effects of CBT-I (see table S4). We recommend that where it is not feasible to assess a broad range of cognitive domains, researchers should focus on the assessment of those cognitive domains where impairments in insomnia samples has been demonstrated most robustly in cross-sectional studies (episodic memory, problem solving and working memory). On the basis of the findings from the highest methodological quality studies included in this review, future studies should also consider including the AFI (a self-report measure probing perceived effectiveness in activities requiring attention and working memory) and ANT-I (a computerised cognitive task probing attentional functioning). In addition, future studies should consider the impact of time of day on cognitive performance and seek to standardise this variable across participants and test sessions ADDIN EN.CITE <EndNote><Cite><Author>Schmidt</Author><Year>2007</Year><RecNum>489</RecNum><DisplayText>(76)</DisplayText><record><rec-number>489</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr">489</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Schmidt, C.</author><author>Collette, F.</author><author>Cajochen, C.</author><author>Peigneux, P.</author></authors></contributors><auth-address>Cyclotron Research Centre, University of Liege, Liege, Belgium.</auth-address><titles><title>A time to think: circadian rhythms in human cognition</title><secondary-title>Cogn Neuropsychol</secondary-title><alt-title>Cognitive neuropsychology</alt-title></titles><periodical><full-title>Cogn Neuropsychol</full-title><abbr-1>Cognitive neuropsychology</abbr-1></periodical><alt-periodical><full-title>Cogn Neuropsychol</full-title><abbr-1>Cognitive neuropsychology</abbr-1></alt-periodical><pages>755-89</pages><volume>24</volume><number>7</number><keywords><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Aging/*psychology</keyword><keyword>Arousal</keyword><keyword>Attention</keyword><keyword>*Circadian Rhythm</keyword><keyword>*Cognition</keyword><keyword>Humans</keyword><keyword>Individuality</keyword><keyword>Inhibition (Psychology)</keyword><keyword>Memory</keyword><keyword>Middle Aged</keyword><keyword>Neuropsychological Tests</keyword><keyword>Problem Solving</keyword><keyword>Psychomotor Performance</keyword><keyword>Sleep</keyword><keyword>*Thinking</keyword><keyword>Wakefulness</keyword></keywords><dates><year>2007</year><pub-dates><date>Oct</date></pub-dates></dates><isbn>1464-0627 (Electronic)
0264-3294 (Linking)</isbn><accession-num>18066734</accession-num><urls><related-urls><url>;(76). There are a number of factors which require consideration with regards to the selection of tools for assessing change in cognitive performance, in individuals with insomnia. Possible explanations for null findings in the studies in this review which utilised objective assessment of cognitive performance, include that the cognitive tasks were not sensitive to sleep or were confounded by ceiling effects. Clearly the test needs to demonstrate sufficient sensitivity to enable the detection of potentially subtle changes over time. There appears to have been little consideration of this issue by the studies included within this review. Individuals with insomnia may compensate for deficits through increased cognitive effort and the recruitment of additional cerebral resources ADDIN EN.CITE <EndNote><Cite><Author>Orff</Author><Year>2007</Year><RecNum>562</RecNum><DisplayText>(93)</DisplayText><record><rec-number>562</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr">562</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Orff, H. J.</author><author>Drummond, S. P.</author><author>Nowakowski, S.</author><author>Perils, M. L.</author></authors></contributors><auth-address>Joint Doctoral Program in Clinical Psychology, San Diego State University and University of California, San Diego, CA, USA.</auth-address><titles><title>Discrepancy between subjective symptomatology and objective neuropsychological performance in insomnia</title><secondary-title>Sleep</secondary-title><alt-title>Sleep</alt-title></titles><periodical><full-title>Sleep</full-title><abbr-1>Sleep</abbr-1></periodical><alt-periodical><full-title>Sleep</full-title><abbr-1>Sleep</abbr-1></alt-periodical><pages>1205-11</pages><volume>30</volume><number>9</number><keywords><keyword>Adult</keyword><keyword>Cognition</keyword><keyword>Cognition Disorders/diagnosis/*etiology</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Memory</keyword><keyword>Middle Aged</keyword><keyword>*Neuropsychological Tests</keyword><keyword>Perception</keyword><keyword>Polysomnography</keyword><keyword>Psychomotor Performance</keyword><keyword>Reaction Time</keyword><keyword>Sleep Initiation and Maintenance Disorders/*complications</keyword><keyword>Task Performance and Analysis</keyword></keywords><dates><year>2007</year><pub-dates><date>Sep</date></pub-dates></dates><isbn>0161-8105 (Print)
0161-8105 (Linking)</isbn><accession-num>17910392</accession-num><urls><related-urls><url>;(93). Such compensation may obscure both objective deficits and improvements over time. Accordingly, it seems important to include cognitive tests which are sufficiently difficult to overwhelm compensatory processes ADDIN EN.CITE <EndNote><Cite><Author>Espie</Author><Year>2008</Year><RecNum>662</RecNum><DisplayText>(96)</DisplayText><record><rec-number>662</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr">662</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Espie, C. A.</author><author>Kyle, S. D.</author></authors></contributors><auth-address>University of Glasgow Sleep Centre, Sackler Institute of Psychobiological Research, Faculty of Medicine, University of Glasgow, Scotland, UK. c.espie@clinmed.gla.ac.uk</auth-address><titles><title>Towards an improved neuropsychology of poor sleep?</title><secondary-title>Sleep</secondary-title></titles><periodical><full-title>Sleep</full-title><abbr-1>Sleep</abbr-1></periodical><pages>591-2</pages><volume>31</volume><number>5</number><keywords><keyword>*Attention</keyword><keyword>Cognition Disorders/*psychology</keyword><keyword>Humans</keyword><keyword>*Neuropsychological Tests</keyword><keyword>*Psychomotor Performance</keyword><keyword>Reaction Time</keyword><keyword>Reference Values</keyword><keyword>Sleep Initiation and Maintenance Disorders/*psychology</keyword></keywords><dates><year>2008</year><pub-dates><date>May</date></pub-dates></dates><isbn>0161-8105 (Print)
0161-8105 (Linking)</isbn><accession-num>18517027</accession-num><urls><related-urls><url>;(96). Edinger and colleagues PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5FZGluZ2VyPC9BdXRob3I+PFllYXI+MjAwODwvWWVhcj48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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5FZGluZ2VyPC9BdXRob3I+PFllYXI+MjAwODwvWWVhcj48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ADDIN EN.CITE.DATA (97) recommend the use of the Switching Attention Test (SAT). The SAT is a computerised cognitive test that presents a series of increasingly challenging psychomotor tasks that assess the participants ability to maintain concentration, switch attention, inhibit responses and make decisions rapidly. Alternatively, future studies could combine manipulations of task difficulty with neuroimaging, so that the role of compensatory mechanisms can be elucidated ADDIN EN.CITE <EndNote><Cite><Author>Drummond</Author><Year>2004</Year><RecNum>572</RecNum><DisplayText>(98)</DisplayText><record><rec-number>572</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr">572</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Drummond, S. P.</author><author>Brown, G. G.</author><author>Salamat, J. S.</author><author>Gillin, J. C.</author></authors></contributors><auth-address>Department of Psychiatry, University of California San Diego, 92161, USA. drummond@ucsd.edu</auth-address><titles><title>Increasing task difficulty facilitates the cerebral compensatory response to total sleep deprivation</title><secondary-title>Sleep</secondary-title><alt-title>Sleep</alt-title></titles><periodical><full-title>Sleep</full-title><abbr-1>Sleep</abbr-1></periodical><alt-periodical><full-title>Sleep</full-title><abbr-1>Sleep</abbr-1></alt-periodical><pages>445-51</pages><volume>27</volume><number>3</number><keywords><keyword>Adult</keyword><keyword>Brain/anatomy & histology/blood supply/*physiopathology</keyword><keyword>Cognition/*physiology</keyword><keyword>Female</keyword><keyword>Hemodynamics/physiology</keyword><keyword>Humans</keyword><keyword>*Magnetic Resonance Imaging</keyword><keyword>Male</keyword><keyword>Sleep Deprivation/*physiopathology</keyword></keywords><dates><year>2004</year><pub-dates><date>May 1</date></pub-dates></dates><isbn>0161-8105 (Print)
0161-8105 (Linking)</isbn><accession-num>15164897</accession-num><urls><related-urls><url>;(98). The subjective outcome measures utilised in the included studies were developed for use in clinical samples, predominantly cancer patients. The validity of using these measures to assess cognitive functioning following an insomnia intervention is questionable. The experience of cognitive impairment related to insomnia may be qualitatively different to that associated with a physical health problem such as cancer. To the best of our knowledge, there are no subjective measures of cognitive functioning that have been specifically-developed for individuals with insomnia. This should be addressed in future research.HeterogeneityMeta-analyses have highlighted various factors which moderate sleep outcomes following CBT-I. These include rate of attrition, length of treatment, level of personal support, method of treatment delivery and duration of insomnia symptoms PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5aYWNoYXJpYWU8L0F1dGhvcj48WWVhcj4yMDE1PC9ZZWFy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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5aYWNoYXJpYWU8L0F1dGhvcj48WWVhcj4yMDE1PC9ZZWFy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ADDIN EN.CITE.DATA (99, 100). Due to the preliminary nature of the literature and the large number of ways in which the included studies varied, it was not possible to identify specific moderators of improvements in cognitive performance. However, future reviews should consider whether there are any variables which enhance the impact of CBT-I on cognitive functioning. It is possible that particular characteristics of an individual with insomnia promote greater improvements in cognitive functioning following treatment. One characteristic that should be examined is cognitive reserve. There is evidence that older adults with less cognitive reserve (as indicated by lower levels of education) are more vulnerable to the negative effects of poor sleep on some aspects of cognitive functioning PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5aaW1tZXJtYW48L0F1dGhvcj48WWVhcj4yMDEyPC9ZZWFy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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5aaW1tZXJtYW48L0F1dGhvcj48WWVhcj4yMDEyPC9ZZWFy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ADDIN EN.CITE.DATA (101). This is thought to result from less capacity for compensation. Improvements in cognitive functioning may therefore be more easily identified in this group. The nature of the insomnia complaint may also moderate outcomes. Specifically, there is evidence that those with objective short sleep duration show greater deficits in cognitive performance PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MbzwvQXV0aG9yPjxZZWFyPjIwMTY8L1llYXI+PFJlY051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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MbzwvQXV0aG9yPjxZZWFyPjIwMTY8L1llYXI+PFJlY051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ADDIN EN.CITE.DATA (102, 103) and therefore we might expect to see greater improvements in cognitive functioning in this group, following an intervention. The majority of studies investigated the impact of CBT-I on cognitive functioning in comorbid samples. This contrasts with the literature on sleep outcomes following CBT-I, which has tended to focus on primary insomnia. It is possible that improvements in cognitive performance following CBT-I, are more likely to be observed in comorbid populations, particularly where cognitive dysfunction is a symptom of the comorbid condition. Limitations of the current reviewThis review has a number of limitations. First, a high proportion of the included studies were from cancer patients, which limits the generalisability of our synthesis. Second, the inclusion criteria used were broad, which resulted in studies that differed on a range of factors, including methodology, population studied, aspects of the intervention and outcomes measures. Such high levels of clinical and methodological diversity precluded the use of meta-analysis and also meant that we were not able to clearly identify factors that contributed to the heterogeneity in outcomes. Third, we included uncontrolled trials and studies with low methodological quality, but resisted drawing conclusions on the basis of their findings, due to high risk of bias. It could be argued that there was little benefit to including these studies however we reasoned that it was necessary to summarise all of the available evidence, given that this is an area of very limited research. Fourth, we combined studies that were very different in terms of content of intervention and method of delivery. For example, we included studies where the intervention combined just two components of CBT-I (relaxation and sleep hygiene), with studies that delivered all of the components. The validity of this is questionable. We did not conduct a meta-analysis and therefore the results from heterogeneous studies were not statistically combined. We suggest that high levels of variability in terms of the interventions delivered is reflective of the current state of the field, whereby there is a lack of clarity concerning the necessary and sufficient components of a CBT-I intervention.ConclusionsThere is preliminary evidence for small-to-moderate effects of CBT-I on self-report cognitive functioning. Included studies tended to have small sample sizes and many failed to find statistically significant results, therefore adequately powered RCTs are required before firm conclusions can be drawn. There is a distinct lack of research with regards to the effects of CBT-I on objective cognitive performance, which is surprising given the importance of cognition for everyday functioning. A consensus with regards to specific cognitive domains that should be assessed in insomnia samples should be a priority for researchers. There was substantial heterogeneity in the included studies, reflecting the broad inclusion criteria used and the preliminary nature of this research area. -476250-393382500Practice PointsImpairments in cognitive functioning are among the most commonly reported and troubling daytime symptoms of insomnia, however little is known about whether insomnia treatments lead to improvements in cognitive performance.There is preliminary evidence for small to moderate positive effects of CBT-I on self-report cognitive functioning however adequately powered RCTs are required before firm conclusions can be drawn.There is a lack of evidence with regards to the impact of CBT-I on objective cognitive performance.Research AgendaFurther research should aim to:Establish a battery of cognitive tests to be used in insomnia samples.Evaluate the effects of CBT-I on cognitive functioning, using a well powered and high quality study design which incorporates an active control condition, so that the specificity of the effects of CBT-I on cognitive performance can be established.Include both subjective and objective measures of cognitive performance and seek to compare the effects of CBT-I on subjective and objective measures. Investigate the mechanisms through which CBT-I leads to improvements in cognitive functioning and establish whether this is different for subjective and objective outcomes.Identify the critical ingredients of CBT-I that enhance improvements in cognitive functioning. References ADDIN EN.REFLIST 1.The international classification of sleep disorders : diagnostic & coding manual. 2nd ed. ed. Westchester, Ill.: American Academy of Sleep Medicine; 2005.2.Edinger JD, Bonnet MH, Bootzin RR, Doghramji K, Dorsey CM, Espie CA, et al. Derivation of research diagnostic criteria for insomnia: report of an American Academy of Sleep Medicine Work Group. Sleep. 2004;27(8):1567-96. Epub 2005/02/03.3.Baglioni C, Battagliese G, Feige B, Spiegelhalder K, Nissen C, Voderholzer U, et al. Insomnia as a predictor of depression: a meta-analytic evaluation of longitudinal epidemiological studies. J Affect Disord. 2011;135(1-3):10-9. Epub 2011/02/09.4.Javaheri S, Redline S. Insomnia and risk of cardiovascular disease. Chest. 2017. Epub 2017/02/06.5.Anothaisintawee T, Reutrakul S, Van Cauter E, Thakkinstian A. Sleep disturbances compared to traditional risk factors for diabetes development: Systematic review and meta-analysis. Sleep medicine reviews. 2016;30:11-24. Epub 2015/12/22.6.Tang NK, Harvey AG. Altering misperception of sleep in insomnia: behavioral experiment versus verbal feedback. Journal of consulting and clinical psychology. 2006;74(4):767-76.7.American Psychiatric Association. Diagnostic and statistical manual of mental disorders : DSM-5. Fifth edition. ed. Arlington, VA: American Psychiatric Publishing; 2013.8.Roth T, Ancoli-Israel S. Daytime consequences and correlates of insomnia in the United States: results of the 1991 National Sleep Foundation Survey. II. Sleep. 1999;22 Suppl 2:S354-8. Epub 1999/07/08.9.Linton SJ, Bryngelsson I. Insomnia and its relationship to work and health in a working-age population. Journal of Occupational Rehabilitation. 2000;10(2):169-83.10.Carey TJ, Moul DE, Pilkonis P, Germain A, Buysse DJ. Focusing on the experience of insomnia. Behavioral sleep medicine. 2005;3(2):73-86. Epub 2005/04/02.11.Kyle SD, Espie CA, Morgan K. "...Not just a minor thing, it is something major, which stops you from functioning daily": quality of life and daytime functioning in insomnia. Behavioral sleep medicine. 2010;8(3):123-40. Epub 2010/06/29.12.Shekleton JA, Rogers NL, Rajaratnam SM. Searching for the daytime impairments of primary insomnia. Sleep medicine reviews. 2010;14(1):47-60. Epub 2009/12/08.*13.Fortier-Brochu E, Beaulieu-Bonneau S, Ivers H, Morin CM. Insomnia and daytime cognitive performance: a meta-analysis. Sleep medicine reviews. 2012;16(1):83-94. Epub 2011/06/04.*14.Lim J, Dinges DF. A meta-analysis of the impact of short-term sleep deprivation on cognitive variables. Psychological bulletin. 2010;136(3):375-89.15.Cricco M, Simonsick EM, Foley DJ. The impact of insomnia on cognitive functioning in older adults. Journal of the American Geriatrics Society. 2001;49(9):1185-9.16.Jelicic M, Bosma H, Ponds RW, Van Boxtel MP, Houx PJ, Jolles J. Subjective sleep problems in later life as predictors of cognitive decline. Report from the Maastricht Ageing Study (MAAS). International journal of geriatric psychiatry. 2002;17(1):73-7.*17.Altena E, Ramautar JR, Van Der Werf YD, Van Someren EJ. Do sleep complaints contribute to age-related cognitive decline? Progress in brain research. 2010;185:181-205.*18.Wilckens KA, Erickson KI, Wheeler ME. Age-related decline in controlled retrieval: the role of the PFC and sleep. Neural plasticity. 2012;2012:624795.19.Kreutzmann JC, Havekes R, Abel T, Meerlo P. Sleep deprivation and hippocampal vulnerability: changes in neuronal plasticity, neurogenesis and cognitive function. Neuroscience. 2015;309:173-90.20.Alhola P, Polo-Kantola P. Sleep deprivation: Impact on cognitive performance. Neuropsychiatric disease and treatment. 2007;3(5):553-67.21.Joo EY, Kim H, Suh S, Hong SB. Hippocampal substructural vulnerability to sleep disturbance and cognitive impairment in patients with chronic primary insomnia: magnetic resonance imaging morphometry. Sleep. 2014;37(7):1189-98.22.Riemann D, Voderholzer U, Spiegelhalder K, Hornyak M, Buysse DJ, Nissen C, et al. Chronic insomnia and MRI-measured hippocampal volumes: a pilot study. Sleep. 2007;30(8):955-8.23.Noh HJ, Joo EY, Kim ST, Yoon SM, Koo DL, Kim D, et al. The relationship between hippocampal volume and cognition in patients with chronic primary insomnia. Journal of clinical neurology. 2012;8(2):130-8.24.Spiegelhalder K, Regen W, Baglioni C, Nissen C, Riemann D, Kyle SD. Neuroimaging insights into insomnia. Current neurology and neuroscience reports. 2015;15(3):9.25.Morin CM, Espie CA. Insomnia : a clinical guide to assessment and treatment. New York ; London: Kluwer Academic/Plenum; 2003.26.Edinger JD, Carney C. Overcoming insomnia : a cognitive-behavioral therapy approach : therapist guide. Oxford ; New York: Oxford University Press; 2008.27.Trauer JM, Qian MY, Doyle JS, Rajaratnam SM, Cunnington D. Cognitive Behavioral Therapy for Chronic Insomnia: A Systematic Review and Meta-analysis. Ann Intern Med. 2015;163(3):191-204. Epub 2015/06/09.28.Wu JQ, Appleman ER, Salazar RD, Ong JC. Cognitive Behavioral Therapy for Insomnia Comorbid With Psychiatric and Medical Conditions: A Meta-analysis. JAMA internal medicine. 2015;175(9):1461-72. Epub 2015/07/07.29.Morin CM, LeBlanc M, Daley M, Gregoire JP, Merette C. Epidemiology of insomnia: prevalence, self-help treatments, consultations, and determinants of help-seeking behaviors. Sleep medicine. 2006;7(2):123-30. Epub 2006/02/07.30.Stepanski E, Koshorek G, Zorick F, Glinn M, Roehrs T, Roth T. Characteristics of individuals who do or do not seek treatment for chronic insomnia. Psychosomatics. 1989;30(4):421-7. Epub 1989/01/01.31.Henry D, McClellen D, Rosenthal L, Dedrick D, Gosdin M. Is sleep really for sissies? Understanding the role of work in insomnia in the US. Soc Sci Med. 2008;66(3):715-26. Epub 2007/11/17.32.Wade AG. The societal costs of insomnia. Neuropsychiatric disease and treatment. 2010;7:1-18. Epub 2011/02/18.33.Kyle SD, Morgan K, Espie CA. Insomnia and health-related quality of life. Sleep medicine reviews. 2010;14(1):69-82. Epub 2009/12/08.34.Espie CA, Kyle SD, Hames P, Cyhlarova E, Benzeval M. The daytime impact of DSM-5 insomnia disorder: comparative analysis of insomnia subtypes from the Great British Sleep Survey. The Journal of clinical psychiatry. 2012;73(12):e1478-84.35.Kyle SD, Crawford MR, Morgan K, Spiegelhalder K, Clark AA, Espie CA. The Glasgow Sleep Impact Index (GSII): a novel patient-centred measure for assessing sleep-related quality of life impairment in Insomnia Disorder. Sleep medicine. 2013;14(6):493-501.36.Leger D, Bayon V, Ohayon MM, Philip P, Ement P, Metlaine A, et al. Insomnia and accidents: cross-sectional study (EQUINOX) on sleep-related home, work and car accidents in 5293 subjects with insomnia from 10 countries. Journal of sleep research. 2014;23(2):143-52.37.Smits CH, Deeg DJ, Kriegsman DM, Schmand B. Cognitive functioning and health as determinants of mortality in an older population. American journal of epidemiology. 1999;150(9):978-86.38.Kyle SD, Aquino MR, Miller CB, Henry AL, Crawford MR, Espie CA, et al. Towards standardisation and improved understanding of sleep restriction therapy for insomnia disorder: A systematic examination of CBT-I trial content. Sleep medicine reviews. 2015;23:83-8. Epub 2015/03/17.39.Bastien CH, Vallieres A, Morin CM. Validation of the Insomnia Severity Index as an outcome measure for insomnia research. Sleep medicine. 2001;2(4):297-307. Epub 2001/07/05.40.Buysse DJ, Reynolds CF, 3rd, Monk TH, Berman SR, Kupfer DJ. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry research. 1989;28(2):193-213. Epub 1989/05/01.41.Morin CM, Benca R. Chronic insomnia. Lancet. 2012;379(9821):1129-41. Epub 2012/01/24.42.Lezak MD, Howieson DB, Loring DW. Neuropsychological assessment. 4th ed. / Muriel D. Lezak, Diane B. Howieson, David W. Loring with H. Julia Hannay and Jill S. Fischer. ed. Oxford: Oxford University Press; 2004.43.Downs SH, Black N. The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions. J Epidemiol Community Health. 1998;52(6):377-84. Epub 1998/10/09.44.Popay J, Roberts H, Sowden A, Petticrew M, Arai L, Rodgers M, et al. Guidance on the conduct of narrative synthesis in systematic reviews: a product from the ESRC methods programme. 2006. University of Lancaster.45.Arnedt JT, Conroy DA, Armitage R, Brower KJ. Cognitive-behavioral therapy for insomnia in alcohol dependent patients: a randomized controlled pilot trial. Behaviour research and therapy. 2011;49(4):227-33. Epub 2011/03/08.46.Arnedt JT, Cuddihy L, Swanson LM, Pickett S, Aikens J, Chervin RD. Randomized controlled trial of telephone-delivered cognitive behavioral therapy for chronic insomnia. Sleep. 2013;36(3):353-62. Epub 2013/03/02.47.Casault L, Savard J, Ivers H, Savard MH. A randomized-controlled trial of an early minimal cognitive-behavioural therapy for insomnia comorbid with cancer. Behaviour research and therapy. 2015;67:45-54. Epub 2015/03/10.48.Jansson M, Linton SJ. Cognitive-behavioral group therapy as an early intervention for insomnia: a randomized controlled trial. J Occup Rehabil. 2005;15(2):177-90. Epub 2005/04/23.49.Matthews EE, Berger AM, Schmiege SJ, Cook PF, McCarthy MS, Moore CM, et al. Cognitive behavioral therapy for insomnia outcomes in women after primary breast cancer treatment: a randomized, controlled trial. Oncol Nurs Forum. 2014;41(3):241-53. Epub 2014/03/22.50.Miro E, Lupianez J, Martinez MP, Sanchez AI, Diaz-Piedra C, Guzman MA, et al. Cognitive-behavioral therapy for insomnia improves attentional function in fibromyalgia syndrome: a pilot, randomized controlled trial. J Health Psychol. 2011;16(5):770-82. Epub 2011/02/25.51.Omvik S, Sivertsen B, Pallesen S, Bjorvatn B, Havik OE, Nordhus IH. Daytime functioning in older patients suffering from chronic insomnia: treatment outcome in a randomized controlled trial comparing CBT with Zopiclone. Behaviour research and therapy. 2008;46(5):623-41. Epub 2008/04/18.52.Ritterband LM, Bailey ET, Thorndike FP, Lord HR, Farrell-Carnahan L, Baum LD. Initial evaluation of an Internet intervention to improve the sleep of cancer survivors with insomnia. Psychooncology. 2012;21(7):695-705. Epub 2011/05/04.53.Sun J, Kang J, Wang P, Zeng H. Self-relaxation training can improve sleep quality and cognitive functions in the older: a one-year randomised controlled trial. J Clin Nurs. 2013;22(9-10):1270-80. Epub 2013/04/12.54.Taylor DJ, Zimmerman MR, Gardner CE, Williams JM, Grieser EA, Tatum JI, et al. A pilot randomized controlled trial of the effects of cognitive-behavioral therapy for insomnia on sleep and daytime functioning in college students. Behav Ther. 2014;45(3):376-89. Epub 2014/04/01.55.Wilckens KA, Hall MH, Nebes RD, Monk TH, Buysse DJ. Changes in Cognitive Performance Are Associated with Changes in Sleep in Older Adults With Insomnia. Behavioral sleep medicine. 2016;14(3):295-310. Epub 2015/09/01.56.Arnedt JT, Conroy D, Rutt J, Aloia MS, Brower KJ, Armitage R. An open trial of cognitive-behavioral treatment for insomnia comorbid with alcohol dependence. Sleep medicine. 2007;8(2):176-80. Epub 2007/01/24.57.Davidson JR, Waisberg JL, Brundage MD, MacLean AW. Nonpharmacologic group treatment of insomnia: a preliminary study with cancer survivors. Psychooncology. 2001;10(5):389-97. Epub 2001/09/06.58.Lami MJ, Martinez MP, Sanchez AI, Miro E, Diener FN, Prados G, et al. Gender Differences in Patients with Fibromyalgia Undergoing Cognitive-Behavioral Therapy for Insomnia: Preliminary Data. Pain Pract. 2016;16(2):E23-34. Epub 2016/02/04.59.Swanson LM, Flynn H, Adams-Mundy JD, Armitage R, Arnedt JT. An open pilot of cognitive-behavioral therapy for insomnia in women with postpartum depression. Behavioral sleep medicine. 2013;11(4):297-307. Epub 2012/12/12.60.Tomfohr-Madsen LM, Clayborne ZM, Rouleau CR, Campbell TS. Sleeping for Two: An Open-Pilot Study of Cognitive Behavioral Therapy for Insomnia in Pregnancy. Behavioral sleep medicine. 2016:1-17. Epub 2016/04/29.61.Simeit R, Deck R, Conta-Marx B. Sleep management training for cancer patients with insomnia. Support Care Cancer. 2004;12(3):176-83. Epub 2004/02/05.62.Quesnel C, Savard J, Simard S, Ivers H, Morin CM. Efficacy of cognitive-behavioral therapy for insomnia in women treated for nonmetastatic breast cancer. J Consult Clin Psychol. 2003;71(1):189-200. Epub 2003/02/27.63.Sivertsen B, Krokstad S, Overland S, Mykletun A. The epidemiology of insomnia: associations with physical and mental health. The HUNT-2 study. Journal of psychosomatic research. 2009;67(2):109-16.64.Diagnostic and statistical manual of mental disorders : DSM-IV. 4th ed. ed. Washington, D.C.: American Psychiatric Association; 1994.65.Smets EM, Garssen B, Bonke B, De Haes JC. The Multidimensional Fatigue Inventory (MFI) psychometric qualities of an instrument to assess fatigue. Journal of psychosomatic research. 1995;39(3):315-25. Epub 1995/04/01.66.Aaronson NK, Ahmedzai S, Bergman B, Bullinger M, Cull A, Duez NJ, et al. The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst. 1993;85(5):365-76. Epub 1993/03/03.67.Cimprich B. Development of an intervention to restore attention in cancer patients. Cancer nursing. 1993;16(2):83-92. Epub 1993/04/01.68.Fan J, McCandliss BD, Sommer T, Raz A, Posner MI. Testing the efficiency and independence of attentional networks. J Cogn Neurosci. 2002;14(3):340-7. Epub 2002/04/24.69.Schuhfried G. Vigilance. M?dling, Austria2004.70.Wechsler D. Wechsler Memory Scale (WMS-III). San Antonio, TX: Psychological Corporation; 1997b.71.Brown R, Sheronbenou RJ, Johnsen SK. Test of nonverbal intelligence. San Antonio, TX: Pearson; 1997.72.Wechsler D. Wechsler Adult Intelligence Scale (WAIS): Administration and scoring manual. San Antonio, TX: Psychological Corporation; 1997a.73.Folstein MF, Folstein SE, McHugh PR. "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12(3):189-98. Epub 1975/11/01.74.Gong YX. Handbook of Wechsler Memory Scale-Revised. Changsha: Hunan Medical College; 1989.75.Kyle SD, Miller CB, Rogers Z, Siriwardena AN, Macmahon KM, Espie CA. Sleep restriction therapy for insomnia is associated with reduced objective total sleep time, increased daytime somnolence, and objectively impaired vigilance: implications for the clinical management of insomnia disorder. Sleep. 2014;37(2):229-37.76.Schmidt C, Collette F, Cajochen C, Peigneux P. A time to think: circadian rhythms in human cognition. Cognitive neuropsychology. 2007;24(7):755-89.77.Kyle SD, Morgan K, Spiegelhalder K, Espie CA. No pain, no gain: an exploratory within-subjects mixed-methods evaluation of the patient experience of sleep restriction therapy (SRT) for insomnia. Sleep medicine. 2011;12(8):735-47.78.Okajima I, Komada Y, Inoue Y. A meta-analysis on the treatment effectiveness of cognitive behavioral therapy for primary insomnia. Sleep Biol Rhythms. 2011;9(1):24-34.79.Edinger JD, Wohlgemuth WK, Radtke RA, Marsh GR, Quillian RE. Cognitive behavioral therapy for treatment of chronic primary insomnia: a randomized controlled trial. Jama. 2001;285(14):1856-64.*80.Oken BS, Flegal K, Zajdel D, Kishiyama S, Haas M, Peters D. Expectancy effect: impact of pill administration on cognitive performance in healthy seniors. Journal of clinical and experimental neuropsychology. 2008;30(1):7-17.81.Schwarz KA, Buchel C. Cognition and the Placebo Effect--Dissociating Subjective Perception and Actual Performance. PloS one. 2015;10(7):e0130492.82.Butler AC, Chapman JE, Forman EM, Beck AT. The empirical status of cognitive-behavioral therapy: a review of meta-analyses. Clinical psychology review. 2006;26(1):17-31.83.Otte C. Cognitive behavioral therapy in anxiety disorders: current state of the evidence. Dialogues in clinical neuroscience. 2011;13(4):413-21.84.Kay DB, Buysse DJ. Hyperarousal and Beyond: New Insights to the Pathophysiology of Insomnia Disorder through Functional Neuroimaging Studies. Brain Sci. 2017;7(3). Epub 2017/03/01.*85.Altena E, Van Der Werf YD, Sanz-Arigita EJ, Voorn TA, Rombouts SA, Kuijer JP, et al. Prefrontal hypoactivation and recovery in insomnia. Sleep. 2008;31(9):1271-6.*86.Wilckens KA, Woo SG, Kirk AR, Erickson KI, Wheeler ME. Role of sleep continuity and total sleep time in executive function across the adult lifespan. Psychology and aging. 2014;29(3):658-65.*87.Wilckens KA, Hall MH, Erickson KI, Germain A, Nimgaonkar VL, Monk TH, et al. Task switching in older adults with and without insomnia. Sleep medicine. 2017;30:113-20. Epub 2017/02/22.88.Riedner BA, Goldstein MR, Plante DT, Rumble ME, Ferrarelli F, Tononi G, et al. Regional Patterns of Elevated Alpha and High-Frequency Electroencephalographic Activity during Nonrapid Eye Movement Sleep in Chronic Insomnia: A Pilot Study. Sleep. 2016;39(4):801-12. Epub 2016/03/05.89.Savard J, Simard S, Ivers H, Morin CM. Randomized study on the efficacy of cognitive-behavioral therapy for insomnia secondary to breast cancer, part I: Sleep and psychological effects. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2005;23(25):6083-96.90.Dirksen SR, Epstein DR. Efficacy of an insomnia intervention on fatigue, mood and quality of life in breast cancer survivors. Journal of advanced nursing. 2008;61(6):664-75.91.Lu W, Krellman JW, Dijkers MP. Can Cognitive Behavioral Therapy for Insomnia also treat fatigue, pain, and mood symptoms in individuals with traumatic brain injury? - A multiple case report. NeuroRehabilitation. 2016;38(1):59-69.92.Smith MT, Huang MI, Manber R. Cognitive behavior therapy for chronic insomnia occurring within the context of medical and psychiatric disorders. Clinical psychology review. 2005;25(5):559-92.*93.Orff HJ, Drummond SP, Nowakowski S, Perils ML. Discrepancy between subjective symptomatology and objective neuropsychological performance in insomnia. Sleep. 2007;30(9):1205-11.94.Harvey AG. A cognitive model of insomnia. Behaviour research and therapy. 2002;40(8):869-93.95.Buysse DJ, Ancoli-Israel S, Edinger JD, Lichstein KL, Morin CM. Recommendations for a standard research assessment of insomnia. Sleep. 2006;29(9):1155-73.96.Espie CA, Kyle SD. Towards an improved neuropsychology of poor sleep? Sleep. 2008;31(5):591-2.97.Edinger JD, Means MK, Carney CE, Krystal AD. Psychomotor performance deficits and their relation to prior nights' sleep among individuals with primary insomnia. Sleep. 2008;31(5):599-607. Epub 2008/06/04.98.Drummond SP, Brown GG, Salamat JS, Gillin JC. Increasing task difficulty facilitates the cerebral compensatory response to total sleep deprivation. Sleep. 2004;27(3):445-51.99.Zachariae R, Lyby MS, Ritterband LM, O'Toole MS. Efficacy of internet-delivered cognitive-behavioral therapy for insomnia - A systematic review and meta-analysis of randomized controlled trials. Sleep medicine reviews. 2015;30:1-10.100.Geiger-Brown JM, Rogers VE, Liu W, Ludeman EM, Downton KD, Diaz-Abad M. Cognitive behavioral therapy in persons with comorbid insomnia: A meta-analysis. Sleep medicine reviews. 2015;23:54-67.101.Zimmerman ME, Bigal ME, Katz MJ, Brickman AM, Lipton RB. Sleep onset/maintenance difficulties and cognitive function in nondemented older adults: the role of cognitive reserve. Journal of the International Neuropsychological Society : JINS. 2012;18(3):461-70.102.Lo JC, Groeger JA, Cheng GH, Dijk DJ, Chee MW. Self-reported sleep duration and cognitive performance in older adults: a systematic review and meta-analysis. Sleep medicine. 2016;17:87-98.103.Fernandez-Mendoza J, Calhoun S, Bixler EO, Pejovic S, Karataraki M, Liao D, et al. Insomnia with objective short sleep duration is associated with deficits in neuropsychological performance: a general population study. Sleep. 2010;33(4):459-65.067310Records identified through database searching (n = 2327)Additional records identified through other sources (n = 9)Total records screened (n = 2336)Duplicates excluded (n = 436)Records screened by title and abstract (n = 1900)Irrelevant papers (n = 1377)Full text articles assessed for eligibility (n = 523)Full text articles excluded (n = 505)No measure of cognition = 245Less than 2 components of CBT-I = 27Intervention included other treatment modality = 9Other = 224Studies included in the review (n = 18)IdentificationScreeningEligibilityIncluded00Records identified through database searching (n = 2327)Additional records identified through other sources (n = 9)Total records screened (n = 2336)Duplicates excluded (n = 436)Records screened by title and abstract (n = 1900)Irrelevant papers (n = 1377)Full text articles assessed for eligibility (n = 523)Full text articles excluded (n = 505)No measure of cognition = 245Less than 2 components of CBT-I = 27Intervention included other treatment modality = 9Other = 224Studies included in the review (n = 18)IdentificationScreeningEligibilityIncludedFigure 1: Search results00Arnedt et al. (2011)Arnedt et al. (2013)Casault et al. (2015)Matthews et al. (2014)Ritterband et al. (2012)Taylor et al. (2014)Favours controlFavours intervention00Arnedt et al. (2011)Arnedt et al. (2013)Casault et al. (2015)Matthews et al. (2014)Ritterband et al. (2012)Taylor et al. (2014)Favours controlFavours interventionFigure 2: Post-intervention standardised mean differences and 95% confidence intervals for subjective measures of cognitive functioning 00Miro et al. 2011: ANT-I ControlMiro et al. 2011: ANT-I OrientingMiro et al. 2011: ANT-I AlertingMiro et al. 2011: ANT-I mean RTOmvik et al. 2008: Vigil RTOmvik et al. 2008: Vigil No. correctWilckens et al. 2008: delayed recallWilckens et al. 2008: abstract reasoningWilckens et al. 2008: working memoryFavours controlFavours intervention00Miro et al. 2011: ANT-I ControlMiro et al. 2011: ANT-I OrientingMiro et al. 2011: ANT-I AlertingMiro et al. 2011: ANT-I mean RTOmvik et al. 2008: Vigil RTOmvik et al. 2008: Vigil No. correctWilckens et al. 2008: delayed recallWilckens et al. 2008: abstract reasoningWilckens et al. 2008: working memoryFavours controlFavours interventionFigure 3: Post-intervention standardised mean differences and 95% confidence intervals for objective measures of cognitive functioning 0-635Arnedt et al. (2013): MFI-20Casault et al. (2015): QLQ-C30Casault et al. (2015): QLQ-C30Matthews et al. (2014): AFIMatthews et al. (2014): AFISun et al. (2013): MMSESun et al. (2013): MMSESun et al. (2013): MMSESun et al. (2013): WMS number memorySun et al. (2013): WMS number memorySun et al. (2013): WMS number memorySun et al. (2013): WMS picture memorySun et al. (2013): WMS picture memorySun et al. (2013): WMS picture memorySun et al. (2013): WMS associative memorySun et al. (2013): WMS associative memorySun et al. (2013): WMS associative memorySun et al. (2013): WMS understanding memorySun et al. (2013): WMS understanding memoryOmvik et al. (2008): Vigil RTOmvik et al. (2008): No. correctJansson & Linton (2005): Concentration difficultiesSun et al.(2013): WMS understanding memory00Arnedt et al. (2013): MFI-20Casault et al. (2015): QLQ-C30Casault et al. (2015): QLQ-C30Matthews et al. (2014): AFIMatthews et al. (2014): AFISun et al. (2013): MMSESun et al. (2013): MMSESun et al. (2013): MMSESun et al. (2013): WMS number memorySun et al. (2013): WMS number memorySun et al. (2013): WMS number memorySun et al. (2013): WMS picture memorySun et al. (2013): WMS picture memorySun et al. (2013): WMS picture memorySun et al. (2013): WMS associative memorySun et al. (2013): WMS associative memorySun et al. (2013): WMS associative memorySun et al. (2013): WMS understanding memorySun et al. (2013): WMS understanding memoryOmvik et al. (2008): Vigil RTOmvik et al. (2008): No. correctJansson & Linton (2005): Concentration difficultiesSun et al.(2013): WMS understanding memory\sFigure 4: Follow-up SMD and 95% confidence intervals for cognitive outcomes. Diamonds represent 12 week follow-up, circles represent 24-32 week follow-up and squares represent 52-58 week follow-up. Subjective cognitive outcomes are displayed above the horizontal line and objective cognitive outcomes are displayed below the horizontal line.Table 1: Characteristics of studiesAuthor(year)DesignPopulationIntervention: components of CBT-I (No. of participants)Mode of deliveryNo of sessionsDurationComparator (No. of participants)Mode of deliveryNo of sessionsDurationMean age % femaleLength of follow upCognitive outcomeSummary of cognitive outcomes at follow upQR score out of 26Arnedt et al. (2007) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bcm5lZHQ8L0F1dGhvcj48WWVhcj4yMDA3PC9ZZWFyPjxS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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bcm5lZHQ8L0F1dGhvcj48WWVhcj4yMDA3PC9ZZWFyPjxS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ADDIN EN.CITE.DATA (56)UTInsomnia comorbid with alcohol dependenceCBTI-A: SR, SC, SH, CT, RP (6)aIndividual4 face-to-face and 4 telephone 8 weeksNone38.6c42.9%c8 weeks after baselineMFI-20 Mental FatigueNo significant improvement between baseline and mid-intervention or post intervention12Arnedt et al. (2011) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bcm5lZHQ8L0F1dGhvcj48WWVhcj4yMDExPC9ZZWFyPjxS
ZWNOdW0+MjQyPC9SZWNOdW0+PERpc3BsYXlUZXh0Pig0NCk8L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+
PHJlYy1udW1iZXI+MjQyPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBk
Yi1pZD0iNXByd2U1c2Exc3oyc3BlZWZ3cjV0eDBveGR3OXN6enhwYXNyIiB0aW1lc3RhbXA9IjE0
NjQ5MDM4MjgiPjI0Mjwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFs
IEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+QXJu
ZWR0LCBKLiBULjwvYXV0aG9yPjxhdXRob3I+Q29ucm95LCBELiBBLjwvYXV0aG9yPjxhdXRob3I+
QXJtaXRhZ2UsIFIuPC9hdXRob3I+PGF1dGhvcj5Ccm93ZXIsIEsuIEouPC9hdXRob3I+PC9hdXRo
b3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+U2xlZXAgYW5kIENocm9ub3BoeXNpb2xv
Z3kgTGFib3JhdG9yeSwgRGVwYXJ0bWVudCBvZiBQc3ljaGlhdHJ5LCBVbml2ZXJzaXR5IG9mIE1p
Y2hpZ2FuLCA0MjUwIFBseW1vdXRoIFJvYWQsIEFubiBBcmJvciwgTUkgNDgxMDktMjcwMCwgVVNB
LiB0YXJuZWR0QG1lZC51bWljaC5lZHU8L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5Db2du
aXRpdmUtYmVoYXZpb3JhbCB0aGVyYXB5IGZvciBpbnNvbW5pYSBpbiBhbGNvaG9sIGRlcGVuZGVu
dCBwYXRpZW50czogYSByYW5kb21pemVkIGNvbnRyb2xsZWQgcGlsb3QgdHJpYWw8L3RpdGxlPjxz
ZWNvbmRhcnktdGl0bGU+QmVoYXYgUmVzIFRoZXI8L3NlY29uZGFyeS10aXRsZT48YWx0LXRpdGxl
PkJlaGF2aW91ciByZXNlYXJjaCBhbmQgdGhlcmFweTwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJp
b2RpY2FsPjxmdWxsLXRpdGxlPkJlaGF2IFJlcyBUaGVyPC9mdWxsLXRpdGxlPjxhYmJyLTE+QmVo
YXZpb3VyIHJlc2VhcmNoIGFuZCB0aGVyYXB5PC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxhbHQtcGVy
aW9kaWNhbD48ZnVsbC10aXRsZT5CZWhhdiBSZXMgVGhlcjwvZnVsbC10aXRsZT48YWJici0xPkJl
aGF2aW91ciByZXNlYXJjaCBhbmQgdGhlcmFweTwvYWJici0xPjwvYWx0LXBlcmlvZGljYWw+PHBh
Z2VzPjIyNy0zMzwvcGFnZXM+PHZvbHVtZT40OTwvdm9sdW1lPjxudW1iZXI+NDwvbnVtYmVyPjxl
ZGl0aW9uPjIwMTEvMDMvMDg8L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFkdWx0PC9rZXl3
b3JkPjxrZXl3b3JkPkFsY29ob2xpc20vKmNvbXBsaWNhdGlvbnM8L2tleXdvcmQ+PGtleXdvcmQ+
KkNvZ25pdGl2ZSBUaGVyYXB5PC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5
d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48a2V5d29yZD5NaWRk
bGUgQWdlZDwva2V5d29yZD48a2V5d29yZD5QaWxvdCBQcm9qZWN0czwva2V5d29yZD48a2V5d29y
ZD5Qb2x5c29tbm9ncmFwaHk8L2tleXdvcmQ+PGtleXdvcmQ+U2luZ2xlLUJsaW5kIE1ldGhvZDwv
a2V5d29yZD48a2V5d29yZD5TbGVlcCBJbml0aWF0aW9uIGFuZCBNYWludGVuYW5jZSBEaXNvcmRl
cnMvY29tcGxpY2F0aW9ucy8qdGhlcmFweTwva2V5d29yZD48a2V5d29yZD5UcmVhdG1lbnQgT3V0
Y29tZTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDExPC95ZWFyPjxwdWItZGF0
ZXM+PGRhdGU+QXByPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTg3My02MjJYIChF
bGVjdHJvbmljKSYjeEQ7MDAwNS03OTY3IChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4y
MTM3NzE0NDwvYWNjZXNzaW9uLW51bT48d29yay10eXBlPlJhbmRvbWl6ZWQgQ29udHJvbGxlZCBU
cmlhbCYjeEQ7UmVzZWFyY2ggU3VwcG9ydCwgTi5JLkguLCBFeHRyYW11cmFsPC93b3JrLXR5cGU+
PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJt
ZWQvMjEzNzcxNDQ8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGN1c3RvbTI+MzA3MzgxMTwv
Y3VzdG9tMj48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTAxNi9qLmJyYXQuMjAxMS4wMi4w
MDM8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVj
b3JkPjwvQ2l0ZT48L0VuZE5vdGU+AG==
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bcm5lZHQ8L0F1dGhvcj48WWVhcj4yMDExPC9ZZWFyPjxS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ADDIN EN.CITE.DATA (45)RCTInsomnia comorbid with alcohol dependenceCBTI-AD: SR, SC, SH, CT (9)aIndividual4 face-to-face and 4 telephone8 weeksBPT (8)aIndividualised4 face-to-face 4 telephone8 weeksCBTI-AD: 46.2a33.3%aBPT:46.1a37.5%a8 weeks after baselineMFI-20 Mental FatigueScores were reduced at post-intervention for both groups. At post-intervention the BPT group reported greater levels of mental fatigue than the CBTI-AD group, however differences were non-significant. 19Arnedt et al. (2013) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bcm5lZHQ8L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFyPjxS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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bcm5lZHQ8L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFyPjxS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ADDIN EN.CITE.DATA (46)RCTChronic insomniaCBTI-Phone: SR, SC, SH, CT, RP (18)aIndividual4-8 telephone4- 8 weeksIPC (15)aParticipants instructed to read and follow recommendations in a CBT-I pamphlet1 telephone session with a study therapist to ensure material was reviewed.CBTI-Phone: 38.1b100%bIPC:40.0b80%b4-8 and 12 weeks after baselineMFI-20 Mental FatigueScores were reduced at post-intervention for both groups and this remained at the 12-week follow-up. No significant difference between the groups at post-intervention or follow-up.17Casault et al. (2015) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DYXNhdWx0PC9BdXRob3I+PFllYXI+MjAxNTwvWWVhcj48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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DYXNhdWx0PC9BdXRob3I+PFllYXI+MjAxNTwvWWVhcj48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ADDIN EN.CITE.DATA (47)RCTInsomnia comorbid with cancermCBT-I: SC, SR, SH, CT, RP (17)aIndividualSelf-help + 3 telephone consultations6 weeksNo treatment control (18)amCBT-I: 56.9c95%cControl: 57.0c88.9%c6, 12 and 24 weeks after baselineQLQ-C30Cognitive FunctioningSignificantly greater improvement in the mCBT-I group from pre-to post-intervention compared to the control group. 20Davidson et al. (2001) ADDIN EN.CITE <EndNote><Cite><Author>Davidson</Author><Year>2001</Year><RecNum>258</RecNum><DisplayText>(56)</DisplayText><record><rec-number>258</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr" timestamp="1464904018">258</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Davidson, J. R.</author><author>Waisberg, J. L.</author><author>Brundage, M. D.</author><author>MacLean, A. W.</author></authors></contributors><auth-address>Department of Psychology, Queen's University, Kingston, Ontario, Canada. davidsnj@post.queensu.ca</auth-address><titles><title>Nonpharmacologic group treatment of insomnia: a preliminary study with cancer survivors</title><secondary-title>Psychooncology</secondary-title><alt-title>Psycho-oncology</alt-title></titles><pages>389-97</pages><volume>10</volume><number>5</number><edition>2001/09/06</edition><keywords><keyword>Attitude to Health</keyword><keyword>Cognitive Therapy/*methods</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Longitudinal Studies</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Neoplasms/*complications/psychology/therapy</keyword><keyword>Patient Education as Topic/*methods</keyword><keyword>Program Evaluation</keyword><keyword>*Relaxation Therapy</keyword><keyword>Severity of Illness Index</keyword><keyword>Sleep Initiation and Maintenance Disorders/*etiology/psychology/*therapy</keyword><keyword>*Survivors/psychology</keyword><keyword>Time Factors</keyword><keyword>Treatment Outcome</keyword></keywords><dates><year>2001</year><pub-dates><date>Sep-Oct</date></pub-dates></dates><isbn>1057-9249 (Print)
1057-9249 (Linking)</isbn><accession-num>11536417</accession-num><work-type>Clinical Trial
Controlled Clinical Trial
Research Support, Non-U.S. Gov't</work-type><urls><related-urls><url>;(57)UTInsomnia comorbid with cancerSleep therapy: SC, SH, CT, RL, RP (12)aGroup6 sessions9 weeksNone54.7a91.7%a4 and 8 weeks after baselineQLQ-C30 Cognitive FunctioningTrend for an improvement in cognitive functioning.11Jansson & Linton(2005) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5KYW5zc29uPC9BdXRob3I+PFllYXI+MjAwNTwvWWVhcj48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=
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5KYW5zc29uPC9BdXRob3I+PFllYXI+MjAwNTwvWWVhcj48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=
ADDIN EN.CITE.DATA (48)RCTChronic insomniaCBT: SC, SR, SH, CT, RP (64)aGroup6 sessions + 1 booster session6 weeks + booster session 2 months after the 6th sessionSelf-help information containing modules on SC, SR and RL (72)a. Participants instructed to read and apply the materialCBT:50.0a,d84%a,dControl: 49.0a,d71%a,d158 weeks after baselineConcentration Difficulties (0-5)Significantly greater reduction in concentration difficulties in the CBT group compared to the control group.17Lami et al.(2016) ADDIN EN.CITE <EndNote><Cite><Author>Lami</Author><Year>2016</Year><RecNum>266</RecNum><DisplayText>(57)</DisplayText><record><rec-number>266</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr" timestamp="1464904102">266</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Lami, M. J.</author><author>Martinez, M. P.</author><author>Sanchez, A. I.</author><author>Miro, E.</author><author>Diener, F. N.</author><author>Prados, G.</author><author>Guzman, M. A.</author></authors></contributors><auth-address>Department of Personality, Assessment, and Psychological Treatment, Faculty of Psychology, University of Granada, Granada, Spain.
Mind, Brain and Behavior Research Center (CIMCYC), University of Granada, Granada, Spain.
Internal Medicine Service, Virgen de las Nieves University Hospital, and Rheumatology Service, Virgen de las Nieves University Hospital, Granada, Spain.</auth-address><titles><title>Gender Differences in Patients with Fibromyalgia Undergoing Cognitive-Behavioral Therapy for Insomnia: Preliminary Data</title><secondary-title>Pain Pract</secondary-title><alt-title>Pain practice : the official journal of World Institute of Pain</alt-title></titles><pages>E23-34</pages><volume>16</volume><number>2</number><edition>2016/02/04</edition><dates><year>2016</year><pub-dates><date>Feb</date></pub-dates></dates><isbn>1533-2500 (Electronic)
1530-7085 (Linking)</isbn><accession-num>26841198</accession-num><work-type>Research Support, Non-U.S. Gov't</work-type><urls><related-urls><url>;(58)UTInsomnia comorbid with fibromyalgiaCBT-I: SC, SR, SH, CT, RL, RP (27 at posttreatment and 24 at follow-up)aGroup9 sessions9 weeksNone46.29b53.6%b9 and 21 weeks after baselineMFI-20 Mental FatigueSignificant improvement in mental fatigue across the three time points. 11Matthews et al. (2014) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NYXR0aGV3czwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NYXR0aGV3czwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+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ADDIN EN.CITE.DATA (49) RCTInsomnia in women following treatment for breast cancerCBTI: SR, SC, SH, CT, RP (32)Individual4 face-to-face and 2 telephone6 weeksBPT (28)Individual4 face-to-face and 2 telephone6 weeksCBTI: 52.1b100%bBPT:52.9b100%b6, 12 and 24 weeks after baselineAttentional Function IndexTrend for a significantly greater improvement from baseline to post-intervention and follow-up in the CBTI group relative to the BPT group.18Miró et al.(2011) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NaXJvPC9BdXRob3I+PFllYXI+MjAxMTwvWWVhcj48UmVj
TnVtPjI3MTwvUmVjTnVtPjxEaXNwbGF5VGV4dD4oNDkpPC9EaXNwbGF5VGV4dD48cmVjb3JkPjxy
ZWMtbnVtYmVyPjI3MTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGIt
aWQ9IjVwcndlNXNhMXN6MnNwZWVmd3I1dHgwb3hkdzlzenp4cGFzciIgdGltZXN0YW1wPSIxNDY0
OTA0MTY4Ij4yNzE8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBB
cnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPk1pcm8s
IEUuPC9hdXRob3I+PGF1dGhvcj5MdXBpYW5leiwgSi48L2F1dGhvcj48YXV0aG9yPk1hcnRpbmV6
LCBNLiBQLjwvYXV0aG9yPjxhdXRob3I+U2FuY2hleiwgQS4gSS48L2F1dGhvcj48YXV0aG9yPkRp
YXotUGllZHJhLCBDLjwvYXV0aG9yPjxhdXRob3I+R3V6bWFuLCBNLiBBLjwvYXV0aG9yPjxhdXRo
b3I+QnVlbGEtQ2FzYWwsIEcuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRo
LWFkZHJlc3M+VW5pdmVyc2lkYWQgZGUgR3JhbmFkYSwgQ2FtcHVzIFVuaXZlcnNpdGFyaW8gZGUg
bGEgQ2FydHVqYSwgcy9uLCBDUC4gMTgwNzEsIEdyYW5hZGEsIFNwYWluLiBlbWlyb0B1Z3IuZTwv
YXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkNvZ25pdGl2ZS1iZWhhdmlvcmFsIHRoZXJhcHkg
Zm9yIGluc29tbmlhIGltcHJvdmVzIGF0dGVudGlvbmFsIGZ1bmN0aW9uIGluIGZpYnJvbXlhbGdp
YSBzeW5kcm9tZTogYSBwaWxvdCwgcmFuZG9taXplZCBjb250cm9sbGVkIHRyaWFsPC90aXRsZT48
c2Vjb25kYXJ5LXRpdGxlPkogSGVhbHRoIFBzeWNob2w8L3NlY29uZGFyeS10aXRsZT48YWx0LXRp
dGxlPkpvdXJuYWwgb2YgaGVhbHRoIHBzeWNob2xvZ3k8L2FsdC10aXRsZT48L3RpdGxlcz48cGFn
ZXM+NzcwLTgyPC9wYWdlcz48dm9sdW1lPjE2PC92b2x1bWU+PG51bWJlcj41PC9udW1iZXI+PGVk
aXRpb24+MjAxMS8wMi8yNTwvZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QWN0aXZpdGllcyBv
ZiBEYWlseSBMaXZpbmcvcHN5Y2hvbG9neTwva2V5d29yZD48a2V5d29yZD5BZHVsdDwva2V5d29y
ZD48a2V5d29yZD5BdHRlbnRpb248L2tleXdvcmQ+PGtleXdvcmQ+KkNvZ25pdGl2ZSBUaGVyYXB5
L21ldGhvZHM8L2tleXdvcmQ+PGtleXdvcmQ+RXhlY3V0aXZlIEZ1bmN0aW9uPC9rZXl3b3JkPjxr
ZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29yZD5GaWJyb215YWxnaWEvY29tcGxpY2F0aW9u
cy9wc3ljaG9sb2d5Lyp0aGVyYXB5PC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48
a2V5d29yZD5NaWRkbGUgQWdlZDwva2V5d29yZD48a2V5d29yZD5OZXVyb3BzeWNob2xvZ2ljYWwg
VGVzdHM8L2tleXdvcmQ+PGtleXdvcmQ+UGlsb3QgUHJvamVjdHM8L2tleXdvcmQ+PGtleXdvcmQ+
U2xlZXA8L2tleXdvcmQ+PGtleXdvcmQ+U2xlZXAgSW5pdGlhdGlvbiBhbmQgTWFpbnRlbmFuY2Ug
RGlzb3JkZXJzL2NvbXBsaWNhdGlvbnMvcHN5Y2hvbG9neS8qdGhlcmFweTwva2V5d29yZD48a2V5
d29yZD5TdXJ2ZXlzIGFuZCBRdWVzdGlvbm5haXJlczwva2V5d29yZD48a2V5d29yZD5UcmVhdG1l
bnQgT3V0Y29tZTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDExPC95ZWFyPjxw
dWItZGF0ZXM+PGRhdGU+SnVsPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTQ2MS03
Mjc3IChFbGVjdHJvbmljKSYjeEQ7MTM1OS0xMDUzIChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9u
LW51bT4yMTM0NjAyMDwvYWNjZXNzaW9uLW51bT48d29yay10eXBlPlJhbmRvbWl6ZWQgQ29udHJv
bGxlZCBUcmlhbCYjeEQ7UmVzZWFyY2ggU3VwcG9ydCwgTm9uLVUuUy4gR292JmFwb3M7dDwvd29y
ay10eXBlPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwOi8vd3d3Lm5jYmkubmxtLm5paC5n
b3YvcHVibWVkLzIxMzQ2MDIwPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmlj
LXJlc291cmNlLW51bT4xMC4xMTc3LzEzNTkxMDUzMTAzOTA1NDQ8L2VsZWN0cm9uaWMtcmVzb3Vy
Y2UtbnVtPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NaXJvPC9BdXRob3I+PFllYXI+MjAxMTwvWWVhcj48UmVj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 EN.CITE.DATA (50)RCTInsomnia comorbid with fibromyalgiaCBT: SC, SR, SH, CT, RL, RP (16)aGroup6 sessions6 weeksSH (15)aGroup6 sessions6 weeksCBT:43.9a,d100%a,dSH:50.2a,d100%a,d7-8 weeks after baselineANT-I taskSignificantly greater improvement in attention-alerting and attention-control in the CBT group compared to the SH group. No significant difference between the groups in change in overall RT or attention-orienting. 17Omvik et al.(2008) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5PbXZpazwvQXV0aG9yPjxZZWFyPjIwMDg8L1llYXI+PFJl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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5PbXZpazwvQXV0aG9yPjxZZWFyPjIwMDg8L1llYXI+PFJl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ADDIN EN.CITE.DATA (51)RCTOlder adults with chronic insomniaCBT: SC, SR, SH, CT, RL (17 post-treatment; 7 follow-up)Individual6-8 sessions6-8 weeksZopliclone 7.5 mg (14 post-treatment; 10 follow-up)6 weeks1 meeting with a psychologist to check adherence to the treatmentCBT:59.7cNRZopiclone:62.0cNR8-10 and 32-34 weeks after baselineVigilance TestChange in performance on this test was not significantly different between the groups.15Quesnel et al. (2003) ADDIN EN.CITE <EndNote><Cite><Author>Quesnel</Author><Year>2003</Year><RecNum>276</RecNum><DisplayText>(61)</DisplayText><record><rec-number>276</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr" timestamp="1464904236">276</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Quesnel, C.</author><author>Savard, J.</author><author>Simard, S.</author><author>Ivers, H.</author><author>Morin, C. M.</author></authors></contributors><auth-address>School of Psychology and Cancer Research Centre, Universite Laval, Quebec, Quebec, Canada.</auth-address><titles><title>Efficacy of cognitive-behavioral therapy for insomnia in women treated for nonmetastatic breast cancer</title><secondary-title>J Consult Clin Psychol</secondary-title><alt-title>Journal of consulting and clinical psychology</alt-title></titles><pages>189-200</pages><volume>71</volume><number>1</number><edition>2003/02/27</edition><keywords><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Breast Neoplasms/*psychology</keyword><keyword>Cognitive Therapy/*methods</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Middle Aged</keyword><keyword>Polysomnography</keyword><keyword>Quality of Life</keyword><keyword>Sleep Initiation and Maintenance Disorders/diagnosis/*etiology/*therapy</keyword><keyword>Surveys and Questionnaires</keyword></keywords><dates><year>2003</year><pub-dates><date>Feb</date></pub-dates></dates><isbn>0022-006X (Print)
0022-006X (Linking)</isbn><accession-num>12602439</accession-num><work-type>Clinical Trial
Research Support, Non-U.S. Gov't</work-type><urls><related-urls><url>;(62)Case seriesInsomnia secondary to metastatic breast cancerCBT: SC, SR, SH, CT, RP (8 at post-treatment; 7 at follow-up)aGroup8 sessions8 weeksNone54.3c100% c8-10, 20-22, and 32-34 weeks after baselineQLQ-C30Cognitive FunctioningSignificant improvement from pre to post intervention and no significant change from post-treatment to follow-up. 10Ritterband et al. (2012) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5SaXR0ZXJiYW5kPC9BdXRob3I+PFllYXI+MjAxMjwvWWVh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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5SaXR0ZXJiYW5kPC9BdXRob3I+PFllYXI+MjAxMjwvWWVh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ADDIN EN.CITE.DATA (52)RCTInsomnia secondary to cancerCBT-I: SC, SR, SH, CT, RP (14)aInternet6 modules6-9 weeksWait list control (14)aCBT-I:53.7a,c100%a,cWLC:59.6a,c71.4%a,c9-11 weeks after baselineMFSI-SFMental FatigueGreater reduction in mental fatigue in the SHUTi group compared to WLC.17Simeit et al.(2004) ADDIN EN.CITE <EndNote><Cite><Author>Simeit</Author><Year>2004</Year><RecNum>279</RecNum><DisplayText>(60)</DisplayText><record><rec-number>279</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr" timestamp="1464904303">279</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Simeit, R.</author><author>Deck, R.</author><author>Conta-Marx, B.</author></authors></contributors><auth-address>Ropersbergklinik Ratzeburg, Ropersberg 47, 23909 Ratzeburg, Germany. info@rkrz.de</auth-address><titles><title>Sleep management training for cancer patients with insomnia</title><secondary-title>Support Care Cancer</secondary-title><alt-title>Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer</alt-title></titles><pages>176-83</pages><volume>12</volume><number>3</number><edition>2004/02/05</edition><keywords><keyword>Attitude to Health</keyword><keyword>Female</keyword><keyword>Health Care Surveys</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Neoplasms/*complications/psychology</keyword><keyword>Patient Education as Topic/*methods</keyword><keyword>Program Evaluation</keyword><keyword>Quality of Life</keyword><keyword>Relaxation Therapy/*education</keyword><keyword>Sleep Initiation and Maintenance Disorders/prevention & control/*rehabilitation</keyword><keyword>Surveys and Questionnaires</keyword></keywords><dates><year>2004</year><pub-dates><date>Mar</date></pub-dates></dates><isbn>0941-4355 (Print)
0941-4355 (Linking)</isbn><accession-num>14760542</accession-num><work-type>Clinical Trial
Controlled Clinical Trial
Research Support, Non-U.S. Gov't</work-type><urls><related-urls><url>;(61)NRTCancer patients with insomnia undergoing rehabilitationSleep management programme: SH, SC, CT, RL, RP.RL: PMR (80)a or AT (71)aGroup3 sessions 3-4 weeksStandard rehabilitation (78)aGroup3-4 weeks PMR:60.2a70%aAT:57.6a80.3aControl: 57.6a75.6%a3/4, 9/10 and 27/28 weeks after baselineQLQ-C30Cognitive FunctioningSignificant improvement between baseline and follow-up for all the groups. Change in scores was not significantly different between the groups. 12Sun et al.(2013) ADDIN EN.CITE <EndNote><Cite><Author>Sun</Author><Year>2013</Year><RecNum>280</RecNum><DisplayText>(52)</DisplayText><record><rec-number>280</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr" timestamp="1464904343">280</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Sun, J.</author><author>Kang, J.</author><author>Wang, P.</author><author>Zeng, H.</author></authors></contributors><auth-address>School of Nursing, Central South University, Changsha, Hunan Province, China.</auth-address><titles><title>Self-relaxation training can improve sleep quality and cognitive functions in the older: a one-year randomised controlled trial</title><secondary-title>J Clin Nurs</secondary-title><alt-title>Journal of clinical nursing</alt-title></titles><pages>1270-80</pages><volume>22</volume><number>9-10</number><edition>2013/04/12</edition><keywords><keyword>Adolescent</keyword><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Aged, 80 and over</keyword><keyword>Analysis of Variance</keyword><keyword>Child</keyword><keyword>*Cognition</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Patient Education as Topic/*methods</keyword><keyword>*Relaxation Therapy</keyword><keyword>*Self Care</keyword><keyword>*Sleep</keyword><keyword>Surveys and Questionnaires</keyword><keyword>Young Adult</keyword></keywords><dates><year>2013</year><pub-dates><date>May</date></pub-dates></dates><isbn>1365-2702 (Electronic)
0962-1067 (Linking)</isbn><accession-num>23574290</accession-num><work-type>Randomized Controlled Trial
Research Support, Non-U.S. Gov't</work-type><urls><related-urls><url>;(53)RCTOlder adult poor sleepersSH, RL (37)aGroup4 sessions4 week intervention with assisted follow up for 1 yearSH (38)aBrochureExperimental: 68.6a,b70.3%a,bControl: 70.8a,b73.3%a,b12, 24 and 52 weeks after baselineMMSE,WMS-CRScores on the MMSE and four subtests from the WMS-CR significantly increased in the experimental group whereas they decreased in the control group.14Swanson et al. (2013) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Td2Fuc29uPC9BdXRob3I+PFllYXI+MjAxMzwvWWVhcj48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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Td2Fuc29uPC9BdXRob3I+PFllYXI+MjAxMzwvWWVhcj48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ADDIN EN.CITE.DATA (59)UTInsomnia comorbid with post-partum depression.CBTI: SC, SR, SH, RL, CT, RP (12)aIndividual5 sessions5 weeksNone30.0a100%a5 weeks after baselineMFI-20Mental FatigueSignificant improvement 10Taylor et al.(2014) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5UYXlsb3I8L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxS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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5UYXlsb3I8L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxS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ADDIN EN.CITE.DATA (54)RCTChronic insomnia in college studentsCBT-I: SC, SR, SH, RL, CT (16)aIndividual6 sessions6 weeksWait list control (13)aCBT-I:19.5c23.5%cWLC:19.9c58.8%c6 and 18 weeks after baselineMFI-20Mental FatigueNo significant difference between the groups in change in mental fatigue.19Tomfohr-Madsen et al. (2016) ADDIN EN.CITE <EndNote><Cite><Author>Tomfohr-Madsen</Author><Year>2016</Year><RecNum>287</RecNum><DisplayText>(59)</DisplayText><record><rec-number>287</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr" timestamp="1464904461">287</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Tomfohr-Madsen, L. M.</author><author>Clayborne, Z. M.</author><author>Rouleau, C. R.</author><author>Campbell, T. S.</author></authors></contributors><auth-address>a Department of Psychology , University of Calgary , Calgary , Alberta , Canada.
b Alberta Children's Hospital Research Institute for Child and Maternal Health , Calgary , Alberta , Canada.
c Department of Pediatrics , Alberta Children's Hospital , Calgary , Alberta , Canada.</auth-address><titles><title>Sleeping for Two: An Open-Pilot Study of Cognitive Behavioral Therapy for Insomnia in Pregnancy</title><secondary-title>Behav Sleep Med</secondary-title><alt-title>Behavioral sleep medicine</alt-title></titles><periodical><full-title>Behav Sleep Med</full-title><abbr-1>Behavioral sleep medicine</abbr-1></periodical><alt-periodical><full-title>Behav Sleep Med</full-title><abbr-1>Behavioral sleep medicine</abbr-1></alt-periodical><pages>1-17</pages><edition>2016/04/29</edition><dates><year>2016</year><pub-dates><date>Apr 28</date></pub-dates></dates><isbn>1540-2010 (Electronic)
1540-2002 (Linking)</isbn><accession-num>27124405</accession-num><urls><related-urls><url>;(60)UTInsomnia in pregnancyCBT-I: SC, SR, CT, RP (13)aGroup5 sessions5 weeksNone31.0a,b100%a,b7 weeks after baselineMFSI-SFMental FatigueSignificant improvement12Wilckens et al.(2016) ADDIN EN.CITE <EndNote><Cite><Author>Wilckens</Author><Year>2016</Year><RecNum>288</RecNum><DisplayText>(54)</DisplayText><record><rec-number>288</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr" timestamp="1464904500">288</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Wilckens, K. A.</author><author>Hall, M. H.</author><author>Nebes, R. D.</author><author>Monk, T. H.</author><author>Buysse, D. J.</author></authors></contributors><auth-address>a Department of Psychiatry , University of Pittsburgh School of Medicine , USA.</auth-address><titles><title>Changes in Cognitive Performance Are Associated with Changes in Sleep in Older Adults With Insomnia</title><secondary-title>Behav Sleep Med</secondary-title><alt-title>Behavioral sleep medicine</alt-title></titles><periodical><full-title>Behav Sleep Med</full-title><abbr-1>Behavioral sleep medicine</abbr-1></periodical><alt-periodical><full-title>Behav Sleep Med</full-title><abbr-1>Behavioral sleep medicine</abbr-1></alt-periodical><pages>295-310</pages><volume>14</volume><number>3</number><edition>2015/09/01</edition><dates><year>2016</year><pub-dates><date>May-Jun</date></pub-dates></dates><isbn>1540-2010 (Electronic)
1540-2002 (Linking)</isbn><accession-num>26322904</accession-num><urls><related-urls><url>;(55)RCTChronic comorbid insomnia in older adultsBBTI: SR, SC (NR)aIndividual2 face-to face sessions and 2 telephone3 weeksInformation-only Control (NR)aParticipants were instructed to read 3 publications containing information about behavioural treatment for insomnia and received a telephone call after two weeks.BBTI:72.665.8%IC:70.571.8%4 weeks after baselineLogical Memory Test, TONI,Letter-number sequencingNo significant difference between treatment groups in change in cognitive performance between baseline and follow-up.12Note. ANT-I task = attentional networks test – interactions task, AT = autogenic training, BBTI = brief behavioural treatment of insomnia, BPT = behavioural placebo treatment, CBT-I = cognitive behavioural therapy for insomnia, CBT-I AD = cognitive behavioural therapy for insomnia in recovering alcohol dependent patients, CBTI-Phone = telephone delivered cognitive behavioural therapy for insomnia, CT = cognitive therapy , IC = information control, IPC = information pamphlet control, mCBT-I = minimal CBT-I, MFI-20 = multidimensional fatigue inventory, MFSI-SF = multidimensional fatigue symptom inventory short form, MMSE = mini mental state exam, NR = not reported, NRT = non-randomised trial, PMR = progressive muscle relaxation, QR = quality rating, RCT = randomised controlled trial, RL = relaxation, RP = relapse prevention, RT = reaction time, SC = stimulus control, SH = sleep hygiene, SR = sleep restriction, TONI = test of nonverbal intelligence, UT = uncontrolled trial, WLC = wait list control, WMS-CR = Wechsler memory scale -Chinese revisiona = data are for participants included in the analysis.b = data are for participants who completed the intervention.c = data are for participants who were recruited/ randomised.d = data are for participants who completed the follow-up.Table S2: Post-intervention and follow-up data used to calculate standardised mean difference (SMD) for subjective measures of cognitive functioningAuthor InterventionCognitive outcomeAssessment point Intervention GroupControl GroupSMD(95% CI)NMeanSDNMeanSDArnedt et al. (2011) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bcm5lZHQ8L0F1dGhvcj48WWVhcj4yMDExPC9ZZWFyPjxS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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bcm5lZHQ8L0F1dGhvcj48WWVhcj4yMDExPC9ZZWFyPjxS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ADDIN EN.CITE.DATA (45)CBTI-ADMFI-20 Mental Fatiguea7 weeks6-7.302.804-9.503.100.75(-0.55, 2.06)Arnedt et al. (2013) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bcm5lZHQ8L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFyPjxS
ZWNOdW0+MjkzPC9SZWNOdW0+PERpc3BsYXlUZXh0Pig0NSk8L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+
PHJlYy1udW1iZXI+MjkzPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBk
Yi1pZD0iNXByd2U1c2Exc3oyc3BlZWZ3cjV0eDBveGR3OXN6enhwYXNyIiB0aW1lc3RhbXA9IjE0
NjQ5MDQ1OTQiPjI5Mzwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFs
IEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+QXJu
ZWR0LCBKLiBULjwvYXV0aG9yPjxhdXRob3I+Q3VkZGloeSwgTC48L2F1dGhvcj48YXV0aG9yPlN3
YW5zb24sIEwuIE0uPC9hdXRob3I+PGF1dGhvcj5QaWNrZXR0LCBTLjwvYXV0aG9yPjxhdXRob3I+
QWlrZW5zLCBKLjwvYXV0aG9yPjxhdXRob3I+Q2hlcnZpbiwgUi4gRC48L2F1dGhvcj48L2F1dGhv
cnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5TbGVlcCBhbmQgQ2hyb25vcGh5c2lvbG9n
eSBMYWJvcmF0b3J5LCBEZXBhcnRtZW50IG9mIFBzeWNoaWF0cnksIFVuaXZlcnNpdHkgb2YgTWlj
aGlnYW4sIEFubiBBcmJvciwgTUkgNDgxMDktMjcwMCwgVVNBLiB0YXJuZWR0QHVtaWNoLmVkdTwv
YXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPlJhbmRvbWl6ZWQgY29udHJvbGxlZCB0cmlhbCBv
ZiB0ZWxlcGhvbmUtZGVsaXZlcmVkIGNvZ25pdGl2ZSBiZWhhdmlvcmFsIHRoZXJhcHkgZm9yIGNo
cm9uaWMgaW5zb21uaWE8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+U2xlZXA8L3NlY29uZGFyeS10
aXRsZT48YWx0LXRpdGxlPlNsZWVwPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1
bGwtdGl0bGU+U2xlZXA8L2Z1bGwtdGl0bGU+PGFiYnItMT5TbGVlcDwvYWJici0xPjwvcGVyaW9k
aWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+U2xlZXA8L2Z1bGwtdGl0bGU+PGFiYnIt
MT5TbGVlcDwvYWJici0xPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjM1My02MjwvcGFnZXM+PHZv
bHVtZT4zNjwvdm9sdW1lPjxudW1iZXI+MzwvbnVtYmVyPjxlZGl0aW9uPjIwMTMvMDMvMDI8L2Vk
aXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFjdGl2aXRpZXMgb2YgRGFpbHkgTGl2aW5nPC9rZXl3
b3JkPjxrZXl3b3JkPkFkdWx0PC9rZXl3b3JkPjxrZXl3b3JkPkNvZ25pdGl2ZSBUaGVyYXB5Lypt
ZXRob2RzPC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29yZD5Gb2xsb3ct
VXAgU3R1ZGllczwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+TWFs
ZTwva2V5d29yZD48a2V5d29yZD5QYXRpZW50IENvbXBsaWFuY2U8L2tleXdvcmQ+PGtleXdvcmQ+
U2xlZXA8L2tleXdvcmQ+PGtleXdvcmQ+U2xlZXAgSW5pdGlhdGlvbiBhbmQgTWFpbnRlbmFuY2Ug
RGlzb3JkZXJzL3BzeWNob2xvZ3kvKnRoZXJhcHk8L2tleXdvcmQ+PGtleXdvcmQ+U3VydmV5cyBh
bmQgUXVlc3Rpb25uYWlyZXM8L2tleXdvcmQ+PGtleXdvcmQ+KlRlbGVwaG9uZTwva2V5d29yZD48
a2V5d29yZD5UcmVhdG1lbnQgT3V0Y29tZTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVh
cj4yMDEzPC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+TWFyPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0
ZXM+PGlzYm4+MTU1MC05MTA5IChFbGVjdHJvbmljKSYjeEQ7MDE2MS04MTA1IChMaW5raW5nKTwv
aXNibj48YWNjZXNzaW9uLW51bT4yMzQ1MDcxMjwvYWNjZXNzaW9uLW51bT48d29yay10eXBlPlJh
bmRvbWl6ZWQgQ29udHJvbGxlZCBUcmlhbCYjeEQ7UmVzZWFyY2ggU3VwcG9ydCwgTi5JLkguLCBF
eHRyYW11cmFsPC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cu
bmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMjM0NTA3MTI8L3VybD48L3JlbGF0ZWQtdXJscz48L3Vy
bHM+PGN1c3RvbTI+MzU3MTc0NjwvY3VzdG9tMj48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAu
NTY2NS9zbGVlcC4yNDQ4PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48bGFuZ3VhZ2U+ZW5nPC9s
YW5ndWFnZT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPgB=
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bcm5lZHQ8L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFyPjxS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ADDIN EN.CITE.DATA (46)CBTI-PhoneMFI-20Mental Fatiguea8 weeks18-8.902.4015-10.62.80.66(-0.05, 1.36)Arnedt et al. (2013) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bcm5lZHQ8L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFyPjxS
ZWNOdW0+MjkzPC9SZWNOdW0+PERpc3BsYXlUZXh0Pig0NSk8L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+
PHJlYy1udW1iZXI+MjkzPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBk
Yi1pZD0iNXByd2U1c2Exc3oyc3BlZWZ3cjV0eDBveGR3OXN6enhwYXNyIiB0aW1lc3RhbXA9IjE0
NjQ5MDQ1OTQiPjI5Mzwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFs
IEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+QXJu
ZWR0LCBKLiBULjwvYXV0aG9yPjxhdXRob3I+Q3VkZGloeSwgTC48L2F1dGhvcj48YXV0aG9yPlN3
YW5zb24sIEwuIE0uPC9hdXRob3I+PGF1dGhvcj5QaWNrZXR0LCBTLjwvYXV0aG9yPjxhdXRob3I+
QWlrZW5zLCBKLjwvYXV0aG9yPjxhdXRob3I+Q2hlcnZpbiwgUi4gRC48L2F1dGhvcj48L2F1dGhv
cnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5TbGVlcCBhbmQgQ2hyb25vcGh5c2lvbG9n
eSBMYWJvcmF0b3J5LCBEZXBhcnRtZW50IG9mIFBzeWNoaWF0cnksIFVuaXZlcnNpdHkgb2YgTWlj
aGlnYW4sIEFubiBBcmJvciwgTUkgNDgxMDktMjcwMCwgVVNBLiB0YXJuZWR0QHVtaWNoLmVkdTwv
YXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPlJhbmRvbWl6ZWQgY29udHJvbGxlZCB0cmlhbCBv
ZiB0ZWxlcGhvbmUtZGVsaXZlcmVkIGNvZ25pdGl2ZSBiZWhhdmlvcmFsIHRoZXJhcHkgZm9yIGNo
cm9uaWMgaW5zb21uaWE8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+U2xlZXA8L3NlY29uZGFyeS10
aXRsZT48YWx0LXRpdGxlPlNsZWVwPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1
bGwtdGl0bGU+U2xlZXA8L2Z1bGwtdGl0bGU+PGFiYnItMT5TbGVlcDwvYWJici0xPjwvcGVyaW9k
aWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+U2xlZXA8L2Z1bGwtdGl0bGU+PGFiYnIt
MT5TbGVlcDwvYWJici0xPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjM1My02MjwvcGFnZXM+PHZv
bHVtZT4zNjwvdm9sdW1lPjxudW1iZXI+MzwvbnVtYmVyPjxlZGl0aW9uPjIwMTMvMDMvMDI8L2Vk
aXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFjdGl2aXRpZXMgb2YgRGFpbHkgTGl2aW5nPC9rZXl3
b3JkPjxrZXl3b3JkPkFkdWx0PC9rZXl3b3JkPjxrZXl3b3JkPkNvZ25pdGl2ZSBUaGVyYXB5Lypt
ZXRob2RzPC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29yZD5Gb2xsb3ct
VXAgU3R1ZGllczwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+TWFs
ZTwva2V5d29yZD48a2V5d29yZD5QYXRpZW50IENvbXBsaWFuY2U8L2tleXdvcmQ+PGtleXdvcmQ+
U2xlZXA8L2tleXdvcmQ+PGtleXdvcmQ+U2xlZXAgSW5pdGlhdGlvbiBhbmQgTWFpbnRlbmFuY2Ug
RGlzb3JkZXJzL3BzeWNob2xvZ3kvKnRoZXJhcHk8L2tleXdvcmQ+PGtleXdvcmQ+U3VydmV5cyBh
bmQgUXVlc3Rpb25uYWlyZXM8L2tleXdvcmQ+PGtleXdvcmQ+KlRlbGVwaG9uZTwva2V5d29yZD48
a2V5d29yZD5UcmVhdG1lbnQgT3V0Y29tZTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVh
cj4yMDEzPC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+TWFyPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0
ZXM+PGlzYm4+MTU1MC05MTA5IChFbGVjdHJvbmljKSYjeEQ7MDE2MS04MTA1IChMaW5raW5nKTwv
aXNibj48YWNjZXNzaW9uLW51bT4yMzQ1MDcxMjwvYWNjZXNzaW9uLW51bT48d29yay10eXBlPlJh
bmRvbWl6ZWQgQ29udHJvbGxlZCBUcmlhbCYjeEQ7UmVzZWFyY2ggU3VwcG9ydCwgTi5JLkguLCBF
eHRyYW11cmFsPC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cu
bmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMjM0NTA3MTI8L3VybD48L3JlbGF0ZWQtdXJscz48L3Vy
bHM+PGN1c3RvbTI+MzU3MTc0NjwvY3VzdG9tMj48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAu
NTY2NS9zbGVlcC4yNDQ4PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48bGFuZ3VhZ2U+ZW5nPC9s
YW5ndWFnZT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPgB=
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Bcm5lZHQ8L0F1dGhvcj48WWVhcj4yMDEzPC9ZZWFyPjxS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ADDIN EN.CITE.DATA (46)CBTI-PhoneMFI-20Mental Fatiguea12 weeks18-8.62.415-10.53.60.63(-0.07, 1.34)Casault et al. (2015) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DYXNhdWx0PC9BdXRob3I+PFllYXI+MjAxNTwvWWVhcj48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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DYXNhdWx0PC9BdXRob3I+PFllYXI+MjAxNTwvWWVhcj48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ADDIN EN.CITE.DATA (47)Minimal CBT-IQLQ-C30Cognitive Functioning6 weeks1786.5713.321872.1823.670.74(0.06, 1.43)Casault et al. (2015) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DYXNhdWx0PC9BdXRob3I+PFllYXI+MjAxNTwvWWVhcj48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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DYXNhdWx0PC9BdXRob3I+PFllYXI+MjAxNTwvWWVhcj48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ADDIN EN.CITE.DATA (47)Minimal CBT-IQLQ-C30Cognitive Functioning12 weeks1782.3515.631883.3320.79-0.05(-0.72, 0.61)Casault et al. (2015) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DYXNhdWx0PC9BdXRob3I+PFllYXI+MjAxNTwvWWVhcj48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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DYXNhdWx0PC9BdXRob3I+PFllYXI+MjAxNTwvWWVhcj48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ADDIN EN.CITE.DATA (47)Minimal CBT-IQLQ-C30Cognitive Functioning24 weeks1783.8215.261882.4116.160.09(-0.57, 0.75)Jansson & Linton(2005) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5KYW5zc29uPC9BdXRob3I+PFllYXI+MjAwNTwvWWVhcj48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=
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5KYW5zc29uPC9BdXRob3I+PFllYXI+MjAwNTwvWWVhcj48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=
ADDIN EN.CITE.DATA (48)CBT-IConcentration Difficulties (0-5)a58 weeks64-2.51.172-2.71.00.19(-0.15, 0.53)Matthews et al. (2014) (49)CBT-IAttentional Function Index6 weeks326.871.76285.782.000.58(0.06, 1.10)Matthews et al. (2014) (49)CBT-IAttentional Function Index12 weeks326.911.98285.851.860.55(0.03, 1.07)Matthews et al. (2014) (49)CBT-IAttentional Function Index24 weeks326.931.84286.291.820.35(-0.16, 0.86)Ritterband et al. (2012) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5SaXR0ZXJiYW5kPC9BdXRob3I+PFllYXI+MjAxMjwvWWVh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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5SaXR0ZXJiYW5kPC9BdXRob3I+PFllYXI+MjAxMjwvWWVh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ADDIN EN.CITE.DATA (52)SHUTiMFSI-SFMental Fatiguea9 weeks14-5.294.2014-5.643.930.09(-0.66, 0.83)Taylor et al.(2014) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5UYXlsb3I8L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxS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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5UYXlsb3I8L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxS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ADDIN EN.CITE.DATA (54)CBT-IMFI-20Mental Fatiguea6 weeks17-9.884.1014-11.383.110.41(-0.31, 1.12)Note. CBT-I = cognitive behavioural therapy for insomnia, CBT-I AD = cognitive behavioural therapy for insomnia in recovering alcohol dependent patients, CBTI-Phone = Telephone delivered cognitive behavioural therapy for insomnia, MFI-20 = multidimensional fatigue inventory, MFSI-SF = multidimensional fatigue symptom inventory short form, SHUTi = sleep healthy using the internet a = mean values were multiplied by -1 to adjust for differences in the direction of measurement.Table S3: Post-intervention and follow-up data used to calculate standardised mean difference (SMD) for objective measures of cognitive functioningAuthor InterventionCognitive outcomeAssessment point Intervention GroupControl GroupSMD(95% CI)NMeanSDNMeanSDMiro et al.(2011) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NaXJvPC9BdXRob3I+PFllYXI+MjAxMTwvWWVhcj48UmVj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 EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NaXJvPC9BdXRob3I+PFllYXI+MjAxMTwvWWVhcj48UmVj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 EN.CITE.DATA (50)CBT-IANT-I Controla7 weeks20-87.9229.1320-104.7033.840.53(-0.12, 1.16)Miro et al.(2011) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NaXJvPC9BdXRob3I+PFllYXI+MjAxMTwvWWVhcj48UmVj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 EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NaXJvPC9BdXRob3I+PFllYXI+MjAxMTwvWWVhcj48UmVj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 EN.CITE.DATA (50)CBT-IANT-IOrienting7 weeks2066.1724.262058.1538.160.25(-0.37, 0.87)Miro et al.(2011) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NaXJvPC9BdXRob3I+PFllYXI+MjAxMTwvWWVhcj48UmVj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 EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NaXJvPC9BdXRob3I+PFllYXI+MjAxMTwvWWVhcj48UmVj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 EN.CITE.DATA (50)CBT-IANT-IAlertinga7 weeks20-51.8531.3320-68.9844.810.44(-0.18, 1.07)Miro et al.(2011) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NaXJvPC9BdXRob3I+PFllYXI+MjAxMTwvWWVhcj48UmVj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 EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NaXJvPC9BdXRob3I+PFllYXI+MjAxMTwvWWVhcj48UmVj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 EN.CITE.DATA (50)CBT-IANT-IMean RTa7 weeks20-617.0078.3920-653.6088.570.44(-0.19, 1.06)Omvik et al.(2008) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5PbXZpazwvQXV0aG9yPjxZZWFyPjIwMDg8L1llYXI+PFJl
Y051bT4yNzI8L1JlY051bT48RGlzcGxheVRleHQ+KDUwKTwvRGlzcGxheVRleHQ+PHJlY29yZD48
cmVjLW51bWJlcj4yNzI8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRi
LWlkPSI1cHJ3ZTVzYTFzejJzcGVlZndyNXR4MG94ZHc5c3p6eHBhc3IiIHRpbWVzdGFtcD0iMTQ2
NDkwNDIwMiI+MjcyPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwg
QXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5PbXZp
aywgUy48L2F1dGhvcj48YXV0aG9yPlNpdmVydHNlbiwgQi48L2F1dGhvcj48YXV0aG9yPlBhbGxl
c2VuLCBTLjwvYXV0aG9yPjxhdXRob3I+QmpvcnZhdG4sIEIuPC9hdXRob3I+PGF1dGhvcj5IYXZp
aywgTy4gRS48L2F1dGhvcj48YXV0aG9yPk5vcmRodXMsIEkuIEguPC9hdXRob3I+PC9hdXRob3Jz
PjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+RGVwYXJ0bWVudCBvZiBDbGluaWNhbCBQc3lj
aG9sb2d5LCBVbml2ZXJzaXR5IG9mIEJlcmdlbiwgQmVyZ2VuLCBOb3J3YXkuIHNpcmkub212aWtA
cHN5a3AudWliLm5vPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+RGF5dGltZSBmdW5jdGlv
bmluZyBpbiBvbGRlciBwYXRpZW50cyBzdWZmZXJpbmcgZnJvbSBjaHJvbmljIGluc29tbmlhOiB0
cmVhdG1lbnQgb3V0Y29tZSBpbiBhIHJhbmRvbWl6ZWQgY29udHJvbGxlZCB0cmlhbCBjb21wYXJp
bmcgQ0JUIHdpdGggWm9waWNsb25lPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkJlaGF2IFJlcyBU
aGVyPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5CZWhhdmlvdXIgcmVzZWFyY2ggYW5kIHRo
ZXJhcHk8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5CZWhhdiBS
ZXMgVGhlcjwvZnVsbC10aXRsZT48YWJici0xPkJlaGF2aW91ciByZXNlYXJjaCBhbmQgdGhlcmFw
eTwvYWJici0xPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+QmVoYXYg
UmVzIFRoZXI8L2Z1bGwtdGl0bGU+PGFiYnItMT5CZWhhdmlvdXIgcmVzZWFyY2ggYW5kIHRoZXJh
cHk8L2FiYnItMT48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz42MjMtNDE8L3BhZ2VzPjx2b2x1bWU+
NDY8L3ZvbHVtZT48bnVtYmVyPjU8L251bWJlcj48ZWRpdGlvbj4yMDA4LzA0LzE4PC9lZGl0aW9u
PjxrZXl3b3Jkcz48a2V5d29yZD5BZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPkF6YWJpY3ljbG8gQ29t
cG91bmRzLyp0aGVyYXBldXRpYyB1c2U8L2tleXdvcmQ+PGtleXdvcmQ+KkNvZ25pdGl2ZSBUaGVy
YXB5PC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tl
eXdvcmQ+PGtleXdvcmQ+SHlwbm90aWNzIGFuZCBTZWRhdGl2ZXMvKnRoZXJhcGV1dGljIHVzZTwv
a2V5d29yZD48a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3b3JkPk1pZGRsZSBBZ2VkPC9rZXl3
b3JkPjxrZXl3b3JkPlBpcGVyYXppbmVzLyp0aGVyYXBldXRpYyB1c2U8L2tleXdvcmQ+PGtleXdv
cmQ+UHN5Y2hpYXRyaWMgU3RhdHVzIFJhdGluZyBTY2FsZXM8L2tleXdvcmQ+PGtleXdvcmQ+UXVh
bGl0eSBvZiBMaWZlPC9rZXl3b3JkPjxrZXl3b3JkPlNsZWVwIEluaXRpYXRpb24gYW5kIE1haW50
ZW5hbmNlIERpc29yZGVycy8qdGhlcmFweTwva2V5d29yZD48a2V5d29yZD5UcmVhdG1lbnQgT3V0
Y29tZTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDA4PC95ZWFyPjxwdWItZGF0
ZXM+PGRhdGU+TWF5PC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MDAwNS03OTY3IChQ
cmludCkmI3hEOzAwMDUtNzk2NyAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MTg0MTcw
OTk8L2FjY2Vzc2lvbi1udW0+PHdvcmstdHlwZT5Db21wYXJhdGl2ZSBTdHVkeSYjeEQ7UmFuZG9t
aXplZCBDb250cm9sbGVkIFRyaWFsJiN4RDtSZXNlYXJjaCBTdXBwb3J0LCBOb24tVS5TLiBHb3Ym
YXBvczt0PC93b3JrLXR5cGU+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHA6Ly93d3cubmNi
aS5ubG0ubmloLmdvdi9wdWJtZWQvMTg0MTcwOTk8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+
PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEwMTYvai5icmF0LjIwMDguMDIuMDEzPC9lbGVj
dHJvbmljLXJlc291cmNlLW51bT48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0Np
dGU+PC9FbmROb3RlPgB=
ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5PbXZpazwvQXV0aG9yPjxZZWFyPjIwMDg8L1llYXI+PFJl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ADDIN EN.CITE.DATA (51)CBT-IVigilRT6-8 weeks17-0.540.0714-0.540.090.00(-0.71, 0.71)Omvik et al.(2008) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5PbXZpazwvQXV0aG9yPjxZZWFyPjIwMDg8L1llYXI+PFJl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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5PbXZpazwvQXV0aG9yPjxZZWFyPjIwMDg8L1llYXI+PFJl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ADDIN EN.CITE.DATA (51)CBT-IVigilNo. correct6-8 weeks1798.591.541498.502.210.05(-0.66, 0.76)Omvik et al.(2008) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5PbXZpazwvQXV0aG9yPjxZZWFyPjIwMDg8L1llYXI+PFJl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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5PbXZpazwvQXV0aG9yPjxZZWFyPjIwMDg8L1llYXI+PFJl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ADDIN EN.CITE.DATA (51)CBT-IVigilRTa30-32 weeks7-0.550.0710-0.570.080.26(-0.71, 1.23)Omvik et al.(2008) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5PbXZpazwvQXV0aG9yPjxZZWFyPjIwMDg8L1llYXI+PFJl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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5PbXZpazwvQXV0aG9yPjxZZWFyPjIwMDg8L1llYXI+PFJl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ADDIN EN.CITE.DATA (51)CBT-IVigilNo. correct30-32 weeks798.861.351099.401.78-0.33(-1.31, 0.64)Sun et al.(2013) ADDIN EN.CITE <EndNote><Cite><Author>Sun</Author><Year>2013</Year><RecNum>280</RecNum><DisplayText>(52)</DisplayText><record><rec-number>280</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr" timestamp="1464904343">280</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Sun, J.</author><author>Kang, J.</author><author>Wang, P.</author><author>Zeng, H.</author></authors></contributors><auth-address>School of Nursing, Central South University, Changsha, Hunan Province, China.</auth-address><titles><title>Self-relaxation training can improve sleep quality and cognitive functions in the older: a one-year randomised controlled trial</title><secondary-title>J Clin Nurs</secondary-title><alt-title>Journal of clinical nursing</alt-title></titles><pages>1270-80</pages><volume>22</volume><number>9-10</number><edition>2013/04/12</edition><keywords><keyword>Adolescent</keyword><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Aged, 80 and over</keyword><keyword>Analysis of Variance</keyword><keyword>Child</keyword><keyword>*Cognition</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Patient Education as Topic/*methods</keyword><keyword>*Relaxation Therapy</keyword><keyword>*Self Care</keyword><keyword>*Sleep</keyword><keyword>Surveys and Questionnaires</keyword><keyword>Young Adult</keyword></keywords><dates><year>2013</year><pub-dates><date>May</date></pub-dates></dates><isbn>1365-2702 (Electronic)
0962-1067 (Linking)</isbn><accession-num>23574290</accession-num><work-type>Randomized Controlled Trial
Research Support, Non-U.S. Gov't</work-type><urls><related-urls><url>;(53)SH + RLMMSE12 weeks3826.302.713723.393.780.89(0.41, 1.36)Sun et al.(2013) ADDIN EN.CITE <EndNote><Cite><Author>Sun</Author><Year>2013</Year><RecNum>280</RecNum><DisplayText>(52)</DisplayText><record><rec-number>280</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr" timestamp="1464904343">280</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Sun, J.</author><author>Kang, J.</author><author>Wang, P.</author><author>Zeng, H.</author></authors></contributors><auth-address>School of Nursing, Central South University, Changsha, Hunan Province, China.</auth-address><titles><title>Self-relaxation training can improve sleep quality and cognitive functions in the older: a one-year randomised controlled trial</title><secondary-title>J Clin Nurs</secondary-title><alt-title>Journal of clinical nursing</alt-title></titles><pages>1270-80</pages><volume>22</volume><number>9-10</number><edition>2013/04/12</edition><keywords><keyword>Adolescent</keyword><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Aged, 80 and over</keyword><keyword>Analysis of Variance</keyword><keyword>Child</keyword><keyword>*Cognition</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Patient Education as Topic/*methods</keyword><keyword>*Relaxation Therapy</keyword><keyword>*Self Care</keyword><keyword>*Sleep</keyword><keyword>Surveys and Questionnaires</keyword><keyword>Young Adult</keyword></keywords><dates><year>2013</year><pub-dates><date>May</date></pub-dates></dates><isbn>1365-2702 (Electronic)
0962-1067 (Linking)</isbn><accession-num>23574290</accession-num><work-type>Randomized Controlled Trial
Research Support, Non-U.S. Gov't</work-type><urls><related-urls><url>;(53)SH + RLNumber memory12 weeks3810.591.77378.971.620.95(0.48, 1.43)Sun et al.(2013) ADDIN EN.CITE <EndNote><Cite><Author>Sun</Author><Year>2013</Year><RecNum>280</RecNum><DisplayText>(52)</DisplayText><record><rec-number>280</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr" timestamp="1464904343">280</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Sun, J.</author><author>Kang, J.</author><author>Wang, P.</author><author>Zeng, H.</author></authors></contributors><auth-address>School of Nursing, Central South University, Changsha, Hunan Province, China.</auth-address><titles><title>Self-relaxation training can improve sleep quality and cognitive functions in the older: a one-year randomised controlled trial</title><secondary-title>J Clin Nurs</secondary-title><alt-title>Journal of clinical nursing</alt-title></titles><pages>1270-80</pages><volume>22</volume><number>9-10</number><edition>2013/04/12</edition><keywords><keyword>Adolescent</keyword><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Aged, 80 and over</keyword><keyword>Analysis of Variance</keyword><keyword>Child</keyword><keyword>*Cognition</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Patient Education as Topic/*methods</keyword><keyword>*Relaxation Therapy</keyword><keyword>*Self Care</keyword><keyword>*Sleep</keyword><keyword>Surveys and Questionnaires</keyword><keyword>Young Adult</keyword></keywords><dates><year>2013</year><pub-dates><date>May</date></pub-dates></dates><isbn>1365-2702 (Electronic)
0962-1067 (Linking)</isbn><accession-num>23574290</accession-num><work-type>Randomized Controlled Trial
Research Support, Non-U.S. Gov't</work-type><urls><related-urls><url>;(53)SH + RLPicture memory12 weeks3810.952.3377.083.331.36(0.86, 1.87)Sun et al.(2013) ADDIN EN.CITE <EndNote><Cite><Author>Sun</Author><Year>2013</Year><RecNum>280</RecNum><DisplayText>(52)</DisplayText><record><rec-number>280</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr" timestamp="1464904343">280</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Sun, J.</author><author>Kang, J.</author><author>Wang, P.</author><author>Zeng, H.</author></authors></contributors><auth-address>School of Nursing, Central South University, Changsha, Hunan Province, China.</auth-address><titles><title>Self-relaxation training can improve sleep quality and cognitive functions in the older: a one-year randomised controlled trial</title><secondary-title>J Clin Nurs</secondary-title><alt-title>Journal of clinical nursing</alt-title></titles><pages>1270-80</pages><volume>22</volume><number>9-10</number><edition>2013/04/12</edition><keywords><keyword>Adolescent</keyword><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Aged, 80 and over</keyword><keyword>Analysis of Variance</keyword><keyword>Child</keyword><keyword>*Cognition</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Patient Education as Topic/*methods</keyword><keyword>*Relaxation Therapy</keyword><keyword>*Self Care</keyword><keyword>*Sleep</keyword><keyword>Surveys and Questionnaires</keyword><keyword>Young Adult</keyword></keywords><dates><year>2013</year><pub-dates><date>May</date></pub-dates></dates><isbn>1365-2702 (Electronic)
0962-1067 (Linking)</isbn><accession-num>23574290</accession-num><work-type>Randomized Controlled Trial
Research Support, Non-U.S. Gov't</work-type><urls><related-urls><url>;(53)SH + RLAssociative memory12 weeks383.651.15371.991.401.30(0.80, 1.80)Sun et al.(2013) ADDIN EN.CITE <EndNote><Cite><Author>Sun</Author><Year>2013</Year><RecNum>280</RecNum><DisplayText>(52)</DisplayText><record><rec-number>280</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr" timestamp="1464904343">280</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Sun, J.</author><author>Kang, J.</author><author>Wang, P.</author><author>Zeng, H.</author></authors></contributors><auth-address>School of Nursing, Central South University, Changsha, Hunan Province, China.</auth-address><titles><title>Self-relaxation training can improve sleep quality and cognitive functions in the older: a one-year randomised controlled trial</title><secondary-title>J Clin Nurs</secondary-title><alt-title>Journal of clinical nursing</alt-title></titles><pages>1270-80</pages><volume>22</volume><number>9-10</number><edition>2013/04/12</edition><keywords><keyword>Adolescent</keyword><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Aged, 80 and over</keyword><keyword>Analysis of Variance</keyword><keyword>Child</keyword><keyword>*Cognition</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Patient Education as Topic/*methods</keyword><keyword>*Relaxation Therapy</keyword><keyword>*Self Care</keyword><keyword>*Sleep</keyword><keyword>Surveys and Questionnaires</keyword><keyword>Young Adult</keyword></keywords><dates><year>2013</year><pub-dates><date>May</date></pub-dates></dates><isbn>1365-2702 (Electronic)
0962-1067 (Linking)</isbn><accession-num>23574290</accession-num><work-type>Randomized Controlled Trial
Research Support, Non-U.S. Gov't</work-type><urls><related-urls><url>;(53)SH + RLUnderstanding memory12 weeks389.863.43375.162.931.47(0.96, 1.98)Sun et al.(2013) ADDIN EN.CITE <EndNote><Cite><Author>Sun</Author><Year>2013</Year><RecNum>280</RecNum><DisplayText>(52)</DisplayText><record><rec-number>280</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr" timestamp="1464904343">280</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Sun, J.</author><author>Kang, J.</author><author>Wang, P.</author><author>Zeng, H.</author></authors></contributors><auth-address>School of Nursing, Central South University, Changsha, Hunan Province, China.</auth-address><titles><title>Self-relaxation training can improve sleep quality and cognitive functions in the older: a one-year randomised controlled trial</title><secondary-title>J Clin Nurs</secondary-title><alt-title>Journal of clinical nursing</alt-title></titles><pages>1270-80</pages><volume>22</volume><number>9-10</number><edition>2013/04/12</edition><keywords><keyword>Adolescent</keyword><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Aged, 80 and over</keyword><keyword>Analysis of Variance</keyword><keyword>Child</keyword><keyword>*Cognition</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Patient Education as Topic/*methods</keyword><keyword>*Relaxation Therapy</keyword><keyword>*Self Care</keyword><keyword>*Sleep</keyword><keyword>Surveys and Questionnaires</keyword><keyword>Young Adult</keyword></keywords><dates><year>2013</year><pub-dates><date>May</date></pub-dates></dates><isbn>1365-2702 (Electronic)
0962-1067 (Linking)</isbn><accession-num>23574290</accession-num><work-type>Randomized Controlled Trial
Research Support, Non-U.S. Gov't</work-type><urls><related-urls><url>;(53)SH + RLMMSE24 weeks3826.465.073722.893.930.79(0.32, 1.26)Sun et al.(2013) ADDIN EN.CITE <EndNote><Cite><Author>Sun</Author><Year>2013</Year><RecNum>280</RecNum><DisplayText>(52)</DisplayText><record><rec-number>280</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr" timestamp="1464904343">280</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Sun, J.</author><author>Kang, J.</author><author>Wang, P.</author><author>Zeng, H.</author></authors></contributors><auth-address>School of Nursing, Central South University, Changsha, Hunan Province, China.</auth-address><titles><title>Self-relaxation training can improve sleep quality and cognitive functions in the older: a one-year randomised controlled trial</title><secondary-title>J Clin Nurs</secondary-title><alt-title>Journal of clinical nursing</alt-title></titles><pages>1270-80</pages><volume>22</volume><number>9-10</number><edition>2013/04/12</edition><keywords><keyword>Adolescent</keyword><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Aged, 80 and over</keyword><keyword>Analysis of Variance</keyword><keyword>Child</keyword><keyword>*Cognition</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Patient Education as Topic/*methods</keyword><keyword>*Relaxation Therapy</keyword><keyword>*Self Care</keyword><keyword>*Sleep</keyword><keyword>Surveys and Questionnaires</keyword><keyword>Young Adult</keyword></keywords><dates><year>2013</year><pub-dates><date>May</date></pub-dates></dates><isbn>1365-2702 (Electronic)
0962-1067 (Linking)</isbn><accession-num>23574290</accession-num><work-type>Randomized Controlled Trial
Research Support, Non-U.S. Gov't</work-type><urls><related-urls><url>;(53)SH + RLNumber memory24 weeks3811.412.65377.841.651.61(1.09, 2.13)Sun et al.(2013) ADDIN EN.CITE <EndNote><Cite><Author>Sun</Author><Year>2013</Year><RecNum>280</RecNum><DisplayText>(52)</DisplayText><record><rec-number>280</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr" timestamp="1464904343">280</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Sun, J.</author><author>Kang, J.</author><author>Wang, P.</author><author>Zeng, H.</author></authors></contributors><auth-address>School of Nursing, Central South University, Changsha, Hunan Province, China.</auth-address><titles><title>Self-relaxation training can improve sleep quality and cognitive functions in the older: a one-year randomised controlled trial</title><secondary-title>J Clin Nurs</secondary-title><alt-title>Journal of clinical nursing</alt-title></titles><pages>1270-80</pages><volume>22</volume><number>9-10</number><edition>2013/04/12</edition><keywords><keyword>Adolescent</keyword><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Aged, 80 and over</keyword><keyword>Analysis of Variance</keyword><keyword>Child</keyword><keyword>*Cognition</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Patient Education as Topic/*methods</keyword><keyword>*Relaxation Therapy</keyword><keyword>*Self Care</keyword><keyword>*Sleep</keyword><keyword>Surveys and Questionnaires</keyword><keyword>Young Adult</keyword></keywords><dates><year>2013</year><pub-dates><date>May</date></pub-dates></dates><isbn>1365-2702 (Electronic)
0962-1067 (Linking)</isbn><accession-num>23574290</accession-num><work-type>Randomized Controlled Trial
Research Support, Non-U.S. Gov't</work-type><urls><related-urls><url>;(53)SH + RLPicture memory24 weeks3812.323.42376.743.091.71(1.18, 2.24)Sun et al.(2013) ADDIN EN.CITE <EndNote><Cite><Author>Sun</Author><Year>2013</Year><RecNum>280</RecNum><DisplayText>(52)</DisplayText><record><rec-number>280</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr" timestamp="1464904343">280</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Sun, J.</author><author>Kang, J.</author><author>Wang, P.</author><author>Zeng, H.</author></authors></contributors><auth-address>School of Nursing, Central South University, Changsha, Hunan Province, China.</auth-address><titles><title>Self-relaxation training can improve sleep quality and cognitive functions in the older: a one-year randomised controlled trial</title><secondary-title>J Clin Nurs</secondary-title><alt-title>Journal of clinical nursing</alt-title></titles><pages>1270-80</pages><volume>22</volume><number>9-10</number><edition>2013/04/12</edition><keywords><keyword>Adolescent</keyword><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Aged, 80 and over</keyword><keyword>Analysis of Variance</keyword><keyword>Child</keyword><keyword>*Cognition</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Patient Education as Topic/*methods</keyword><keyword>*Relaxation Therapy</keyword><keyword>*Self Care</keyword><keyword>*Sleep</keyword><keyword>Surveys and Questionnaires</keyword><keyword>Young Adult</keyword></keywords><dates><year>2013</year><pub-dates><date>May</date></pub-dates></dates><isbn>1365-2702 (Electronic)
0962-1067 (Linking)</isbn><accession-num>23574290</accession-num><work-type>Randomized Controlled Trial
Research Support, Non-U.S. Gov't</work-type><urls><related-urls><url>;(53)SH + RLAssociative memory24 weeks384.381.45371.831.151.95(1.40, 2.50)Sun et al.(2013) ADDIN EN.CITE <EndNote><Cite><Author>Sun</Author><Year>2013</Year><RecNum>280</RecNum><DisplayText>(52)</DisplayText><record><rec-number>280</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr" timestamp="1464904343">280</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Sun, J.</author><author>Kang, J.</author><author>Wang, P.</author><author>Zeng, H.</author></authors></contributors><auth-address>School of Nursing, Central South University, Changsha, Hunan Province, China.</auth-address><titles><title>Self-relaxation training can improve sleep quality and cognitive functions in the older: a one-year randomised controlled trial</title><secondary-title>J Clin Nurs</secondary-title><alt-title>Journal of clinical nursing</alt-title></titles><pages>1270-80</pages><volume>22</volume><number>9-10</number><edition>2013/04/12</edition><keywords><keyword>Adolescent</keyword><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Aged, 80 and over</keyword><keyword>Analysis of Variance</keyword><keyword>Child</keyword><keyword>*Cognition</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Patient Education as Topic/*methods</keyword><keyword>*Relaxation Therapy</keyword><keyword>*Self Care</keyword><keyword>*Sleep</keyword><keyword>Surveys and Questionnaires</keyword><keyword>Young Adult</keyword></keywords><dates><year>2013</year><pub-dates><date>May</date></pub-dates></dates><isbn>1365-2702 (Electronic)
0962-1067 (Linking)</isbn><accession-num>23574290</accession-num><work-type>Randomized Controlled Trial
Research Support, Non-U.S. Gov't</work-type><urls><related-urls><url>;(53)SH + RLUnderstanding memory24 weeks3811.033.51376.052.791.57(1.05, 2.09)Sun et al.(2013) ADDIN EN.CITE <EndNote><Cite><Author>Sun</Author><Year>2013</Year><RecNum>280</RecNum><DisplayText>(52)</DisplayText><record><rec-number>280</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr" timestamp="1464904343">280</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Sun, J.</author><author>Kang, J.</author><author>Wang, P.</author><author>Zeng, H.</author></authors></contributors><auth-address>School of Nursing, Central South University, Changsha, Hunan Province, China.</auth-address><titles><title>Self-relaxation training can improve sleep quality and cognitive functions in the older: a one-year randomised controlled trial</title><secondary-title>J Clin Nurs</secondary-title><alt-title>Journal of clinical nursing</alt-title></titles><pages>1270-80</pages><volume>22</volume><number>9-10</number><edition>2013/04/12</edition><keywords><keyword>Adolescent</keyword><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Aged, 80 and over</keyword><keyword>Analysis of Variance</keyword><keyword>Child</keyword><keyword>*Cognition</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Patient Education as Topic/*methods</keyword><keyword>*Relaxation Therapy</keyword><keyword>*Self Care</keyword><keyword>*Sleep</keyword><keyword>Surveys and Questionnaires</keyword><keyword>Young Adult</keyword></keywords><dates><year>2013</year><pub-dates><date>May</date></pub-dates></dates><isbn>1365-2702 (Electronic)
0962-1067 (Linking)</isbn><accession-num>23574290</accession-num><work-type>Randomized Controlled Trial
Research Support, Non-U.S. Gov't</work-type><urls><related-urls><url>;(53)SH + RLMMSE52 weeks3827.572.263722.713.671.60(1.08, 2.12)Sun et al.(2013) ADDIN EN.CITE <EndNote><Cite><Author>Sun</Author><Year>2013</Year><RecNum>280</RecNum><DisplayText>(52)</DisplayText><record><rec-number>280</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr" timestamp="1464904343">280</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Sun, J.</author><author>Kang, J.</author><author>Wang, P.</author><author>Zeng, H.</author></authors></contributors><auth-address>School of Nursing, Central South University, Changsha, Hunan Province, China.</auth-address><titles><title>Self-relaxation training can improve sleep quality and cognitive functions in the older: a one-year randomised controlled trial</title><secondary-title>J Clin Nurs</secondary-title><alt-title>Journal of clinical nursing</alt-title></titles><pages>1270-80</pages><volume>22</volume><number>9-10</number><edition>2013/04/12</edition><keywords><keyword>Adolescent</keyword><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Aged, 80 and over</keyword><keyword>Analysis of Variance</keyword><keyword>Child</keyword><keyword>*Cognition</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Patient Education as Topic/*methods</keyword><keyword>*Relaxation Therapy</keyword><keyword>*Self Care</keyword><keyword>*Sleep</keyword><keyword>Surveys and Questionnaires</keyword><keyword>Young Adult</keyword></keywords><dates><year>2013</year><pub-dates><date>May</date></pub-dates></dates><isbn>1365-2702 (Electronic)
0962-1067 (Linking)</isbn><accession-num>23574290</accession-num><work-type>Randomized Controlled Trial
Research Support, Non-U.S. Gov't</work-type><urls><related-urls><url>;(53)SH + RLNumber memory52 weeks3811.621.80377.531.333.38(2.68, 4.09)Sun et al.(2013) ADDIN EN.CITE <EndNote><Cite><Author>Sun</Author><Year>2013</Year><RecNum>280</RecNum><DisplayText>(52)</DisplayText><record><rec-number>280</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr" timestamp="1464904343">280</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Sun, J.</author><author>Kang, J.</author><author>Wang, P.</author><author>Zeng, H.</author></authors></contributors><auth-address>School of Nursing, Central South University, Changsha, Hunan Province, China.</auth-address><titles><title>Self-relaxation training can improve sleep quality and cognitive functions in the older: a one-year randomised controlled trial</title><secondary-title>J Clin Nurs</secondary-title><alt-title>Journal of clinical nursing</alt-title></titles><pages>1270-80</pages><volume>22</volume><number>9-10</number><edition>2013/04/12</edition><keywords><keyword>Adolescent</keyword><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Aged, 80 and over</keyword><keyword>Analysis of Variance</keyword><keyword>Child</keyword><keyword>*Cognition</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Patient Education as Topic/*methods</keyword><keyword>*Relaxation Therapy</keyword><keyword>*Self Care</keyword><keyword>*Sleep</keyword><keyword>Surveys and Questionnaires</keyword><keyword>Young Adult</keyword></keywords><dates><year>2013</year><pub-dates><date>May</date></pub-dates></dates><isbn>1365-2702 (Electronic)
0962-1067 (Linking)</isbn><accession-num>23574290</accession-num><work-type>Randomized Controlled Trial
Research Support, Non-U.S. Gov't</work-type><urls><related-urls><url>;(53)SH + RLPicture memory52 weeks3812.682.38376.392.442.61(1.99, 3.23)Sun et al.(2013) ADDIN EN.CITE <EndNote><Cite><Author>Sun</Author><Year>2013</Year><RecNum>280</RecNum><DisplayText>(52)</DisplayText><record><rec-number>280</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr" timestamp="1464904343">280</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Sun, J.</author><author>Kang, J.</author><author>Wang, P.</author><author>Zeng, H.</author></authors></contributors><auth-address>School of Nursing, Central South University, Changsha, Hunan Province, China.</auth-address><titles><title>Self-relaxation training can improve sleep quality and cognitive functions in the older: a one-year randomised controlled trial</title><secondary-title>J Clin Nurs</secondary-title><alt-title>Journal of clinical nursing</alt-title></titles><pages>1270-80</pages><volume>22</volume><number>9-10</number><edition>2013/04/12</edition><keywords><keyword>Adolescent</keyword><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Aged, 80 and over</keyword><keyword>Analysis of Variance</keyword><keyword>Child</keyword><keyword>*Cognition</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Patient Education as Topic/*methods</keyword><keyword>*Relaxation Therapy</keyword><keyword>*Self Care</keyword><keyword>*Sleep</keyword><keyword>Surveys and Questionnaires</keyword><keyword>Young Adult</keyword></keywords><dates><year>2013</year><pub-dates><date>May</date></pub-dates></dates><isbn>1365-2702 (Electronic)
0962-1067 (Linking)</isbn><accession-num>23574290</accession-num><work-type>Randomized Controlled Trial
Research Support, Non-U.S. Gov't</work-type><urls><related-urls><url>;(53)SH + RLAssociative memory52 weeks384.781.56371.741.012.31(1.72, 2.89)Sun et al.(2013) ADDIN EN.CITE <EndNote><Cite><Author>Sun</Author><Year>2013</Year><RecNum>280</RecNum><DisplayText>(52)</DisplayText><record><rec-number>280</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr" timestamp="1464904343">280</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Sun, J.</author><author>Kang, J.</author><author>Wang, P.</author><author>Zeng, H.</author></authors></contributors><auth-address>School of Nursing, Central South University, Changsha, Hunan Province, China.</auth-address><titles><title>Self-relaxation training can improve sleep quality and cognitive functions in the older: a one-year randomised controlled trial</title><secondary-title>J Clin Nurs</secondary-title><alt-title>Journal of clinical nursing</alt-title></titles><pages>1270-80</pages><volume>22</volume><number>9-10</number><edition>2013/04/12</edition><keywords><keyword>Adolescent</keyword><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Aged, 80 and over</keyword><keyword>Analysis of Variance</keyword><keyword>Child</keyword><keyword>*Cognition</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Patient Education as Topic/*methods</keyword><keyword>*Relaxation Therapy</keyword><keyword>*Self Care</keyword><keyword>*Sleep</keyword><keyword>Surveys and Questionnaires</keyword><keyword>Young Adult</keyword></keywords><dates><year>2013</year><pub-dates><date>May</date></pub-dates></dates><isbn>1365-2702 (Electronic)
0962-1067 (Linking)</isbn><accession-num>23574290</accession-num><work-type>Randomized Controlled Trial
Research Support, Non-U.S. Gov't</work-type><urls><related-urls><url>;(53)SH + RLUnderstanding memory52 weeks3811.413.26376.502.651.65(1.12, 2.18)Wilckens et al.(2016) ADDIN EN.CITE <EndNote><Cite><Author>Wilckens</Author><Year>2016</Year><RecNum>288</RecNum><DisplayText>(54)</DisplayText><record><rec-number>288</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr" timestamp="1464904500">288</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Wilckens, K. A.</author><author>Hall, M. H.</author><author>Nebes, R. D.</author><author>Monk, T. H.</author><author>Buysse, D. J.</author></authors></contributors><auth-address>a Department of Psychiatry , University of Pittsburgh School of Medicine , USA.</auth-address><titles><title>Changes in Cognitive Performance Are Associated with Changes in Sleep in Older Adults With Insomnia</title><secondary-title>Behav Sleep Med</secondary-title><alt-title>Behavioral sleep medicine</alt-title></titles><periodical><full-title>Behav Sleep Med</full-title><abbr-1>Behavioral sleep medicine</abbr-1></periodical><alt-periodical><full-title>Behav Sleep Med</full-title><abbr-1>Behavioral sleep medicine</abbr-1></alt-periodical><pages>295-310</pages><volume>14</volume><number>3</number><edition>2015/09/01</edition><dates><year>2016</year><pub-dates><date>May-Jun</date></pub-dates></dates><isbn>1540-2010 (Electronic)
1540-2002 (Linking)</isbn><accession-num>26322904</accession-num><urls><related-urls><url>;(55)BBTIDelayed recall4 weeks3820.46.83919.07.70.19(-0.26, 0.64)Wilckens et al.(2016) ADDIN EN.CITE <EndNote><Cite><Author>Wilckens</Author><Year>2016</Year><RecNum>288</RecNum><DisplayText>(54)</DisplayText><record><rec-number>288</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr" timestamp="1464904500">288</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Wilckens, K. A.</author><author>Hall, M. H.</author><author>Nebes, R. D.</author><author>Monk, T. H.</author><author>Buysse, D. J.</author></authors></contributors><auth-address>a Department of Psychiatry , University of Pittsburgh School of Medicine , USA.</auth-address><titles><title>Changes in Cognitive Performance Are Associated with Changes in Sleep in Older Adults With Insomnia</title><secondary-title>Behav Sleep Med</secondary-title><alt-title>Behavioral sleep medicine</alt-title></titles><periodical><full-title>Behav Sleep Med</full-title><abbr-1>Behavioral sleep medicine</abbr-1></periodical><alt-periodical><full-title>Behav Sleep Med</full-title><abbr-1>Behavioral sleep medicine</abbr-1></alt-periodical><pages>295-310</pages><volume>14</volume><number>3</number><edition>2015/09/01</edition><dates><year>2016</year><pub-dates><date>May-Jun</date></pub-dates></dates><isbn>1540-2010 (Electronic)
1540-2002 (Linking)</isbn><accession-num>26322904</accession-num><urls><related-urls><url>;(55)BBTIAbstract reasoning4 weeks3825.86.33927.46.0-0.26(-0.72, 0.19)Wilckens et al.(2016) ADDIN EN.CITE <EndNote><Cite><Author>Wilckens</Author><Year>2016</Year><RecNum>288</RecNum><DisplayText>(54)</DisplayText><record><rec-number>288</rec-number><foreign-keys><key app="EN" db-id="5prwe5sa1sz2speefwr5tx0oxdw9szzxpasr" timestamp="1464904500">288</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Wilckens, K. A.</author><author>Hall, M. H.</author><author>Nebes, R. D.</author><author>Monk, T. H.</author><author>Buysse, D. J.</author></authors></contributors><auth-address>a Department of Psychiatry , University of Pittsburgh School of Medicine , USA.</auth-address><titles><title>Changes in Cognitive Performance Are Associated with Changes in Sleep in Older Adults With Insomnia</title><secondary-title>Behav Sleep Med</secondary-title><alt-title>Behavioral sleep medicine</alt-title></titles><periodical><full-title>Behav Sleep Med</full-title><abbr-1>Behavioral sleep medicine</abbr-1></periodical><alt-periodical><full-title>Behav Sleep Med</full-title><abbr-1>Behavioral sleep medicine</abbr-1></alt-periodical><pages>295-310</pages><volume>14</volume><number>3</number><edition>2015/09/01</edition><dates><year>2016</year><pub-dates><date>May-Jun</date></pub-dates></dates><isbn>1540-2010 (Electronic)
1540-2002 (Linking)</isbn><accession-num>26322904</accession-num><urls><related-urls><url>;(55)BBTIWorking memory4 weeks3811.12.63910.42.50.27(-0.17, 0.72)Note. ANT-I = attentional networks test – interactions task, BBTI = brief behavioural treatment of insomnia, CBT-I = cognitive behavioural therapy for insomnia, MMSE = mini mental state exam, RL = relaxation, RT = reaction time, SH = sleep hygiene, TONI = test of nonverbal intelligence, UT = uncontrolled trial, WLC = wait list control, WMS-CR = Wechsler memory scale -Chinese revision a = mean values were multiplied by -1 to adjust for differences in the direction of measurement.Table S4: Treatment effect across cognitive domainsArnedt et al., 2007Arnedt et al., 2011Arnedt et al., 2013Casault et al., 2015Davidson et al., 2001Jansson & Linton, 2005Lami et al., 2016Matthews et al., 2014Miro et al., 2011Omvik et al., 2008Quesnel et al., 2003Ritterband et al., 2002Simeit et al., 2004Sun et al., 2013Swanson et al., 2013Taylor et al., 2014Tomfohr-Madsen et al., 2016Wilckens et al., 2016Self-Report cognitive performanceConcentrationxxxxConcentration and memory Trend xAttention, concentration and memory Attention, memory and executive functioningTrend Objectively assessed cognitive performanceSustained attentionxExecutive functioningxMemoryxGeneral cognitive performanceNote. = significant effect of treatment, x = no effect of treatment, Trend = trend for an effect of the treatment ................
................
In order to avoid copyright disputes, this page is only a partial summary.
To fulfill the demand for quickly locating and searching documents.
It is intelligent file search solution for home and business.
Related searches
- university of minnesota college of education
- university of minnesota school of social work
- wharton school of the university of pennsylvania
- cost of university of scranton
- university of minnesota school of education
- university of scranton cost of attendance
- university of south florida college of medicine
- university of minnesota masters of social work
- ecampus of university of phoenix
- university of minnesota college of continuing education
- university of illinois college of nursing
- university of north texas college of nursing