The ‘Dopamine Hypothesis’ suggests that schizophrenia ...



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| |Diagram – Normal Nerve Cells |Diagram - Schizophrenic Nerve Cells |

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|The ‘Dopamine Hypothesis’ suggests that schizophrenia results from | | |

|over-activity in the brain dopamine systems. | | |

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|Owen et al. (1978) found increased levels of dopamine and a | | |

|relative excess of dopamine receptors in the brain tissue of | | |

|schizophrenic patients. | | |

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|How does the action of drugs support or challenge the ‘Dopamine |Do drugs treat everyone suffering from schizophrenia effectively? |Does this affect the conclusions that can be made about the role of dopamine|

|Hypothesis’? | |in schizophrenia? |

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| |Which symptoms of schizophrenia do drugs treat? | |

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|Parkinson's disease is a movement disorder that affects 1-2% of the general population. |How can the action of the drug L-Dopa be used to evaluate the ‘Dopamine Hypothesis’? |

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|How is dopamine linked to Parkinson’s Disease? | |

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| |Why do you think cases of Parkinson’s disease amongst schizophrenics are extremely rare? |

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| |Does the action of these drugs support or challenge the ‘Dopamine Hypothesis’? |

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| |What conclusions can be drawn from PET scans? |

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Dopamine Hypothesis (AO1 & AO2)

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