Neuroscience.jhu.edu



Murine Mutagenesis Core PublicationsPublications Supported by the Murine Metagenesis Core2007Luo W, Wickramsinghe SR, Savitt JM, Griffin JW, Dawson TM, Ginty DD. 2007. A hierarchical NGF signaling cascade controls Ret-dependent and Ret-independent events during development of non-peptidergic DRG neurons. Neuron 54:739-754.2008Deppmann CD, Mihalas S, Sharma N, Lonze BE, Neibur E, Ginty DD. 2008. A model for neuronal competition during development. Science 320:369-73.Newbern J, Zhong J, Wickramasinghe RS, Li X, Wu Y, Samuels I, Cherosky N, Karlo JC, O'Loughlin B, Wikenheiser J, Gargesha M, Doughman YQ, Charron J, Ginty DD, Watanabe M, Saitta SC, Snider WD, Landreth GE. 2008. Mouse and human phenotypes indicate a critical conserved role for ERK2 signaling in neural crest development. Proc Natl Acad Sci 105:17115-20. PMCID:PMC2579387.Wickramasinghe SR, Alvania RS, Ramanan N, Wood JN, Mandai K, Ginty DD. 2008. Serum Response Factor mediates NGF dependent target innervation by embryonic DRG sensory neurons. Neuron 58:532-45. PMCID:PMC2689374.2009Cozzoli DK, Goulding SP, Zhang PW, Xiao B, Hu JH, Ary AW, Obara I, Rahn A, Abou-Ziab H, Tyrrel B, Marini C, Yoneyama N, Metten P, Snelling C, Dehoff MH, Crabbe JC, Finn DA, Klugmann M, Worley PF, Szumlinski KK. 2009. Binge drinking upregulates accumbens mGluR5-Homer2-PI3K signaling: functional implications for alcoholism. J Neurosci 29:8655-8668. PMCID:PMC2761716.Delgoffe GM, Kole TP, Zheng Y, Zarek PE, Matthews KL, Xiao B, Worley PF, Kozma SC, Powell JD. 2009. The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment. Immunity 30: 832-844. PMCID:PMC2768135.Luo W, Enomoto H, Rice FL, Milbrandt J, Ginty DD. 2009. Molecular identification of rapidly adapting mechanoreceptors and their developmental dependence on Ret signaling. Neuron 64:841-856. PMCID:PMC2813518.2010Abazyan B, Nomura J, Kannan G, Ishizuka K, Tamashiro KL, Nucifora F, Pogorelov V, Ladenheim B, Yang C, Krasnova IN, Cadet JL, Pardo C, Mori S, Kamiya A, Vogel MW, Sawa A, Ross CA, Pletnikov MV. 2010. Prenatal interaction of mutant DISC1 and immune activation produces adult psychopathology. Biol Psychiatry 68:1172-81. PMCID:PMC3026608.Chiang PM, Ling J, Jeong YH, Price DL, Aja SM, Wong PC. 2010. Deletion of TDP-43 down-regulates Tbc1d1, a gene linked to obesity, and alters body fat metabolism. Proc Nat Acad Sci USA 107:16320-4. PMCID:PMC2941284.Hu JH, Park JM, Park S, Xiao B, Dehoff MH, Kim S, Hayashi T, Schwarz MK, Huganir RL, Seeburg PH, Linden DJ, WORLEY PF. 2010. Homeostatic scaling requires group I mGluR activation mediated by Homer1a. Neuron 68:1128-42. PMCID:PMC3013614.Lee SJ, Lee YS, Zimmers TA, Soleimani A, Matzuk MM, Tsuchida K Cohn RD, Barton ER. 2010. Regulation of muscle mass by follistatin and activins. Mol Endocrinol 24:1998-2008. PMCID:PMC2954636.Sharma N, Deppmann CD, Harrington AW, St Hillaire C, Chen ZY, Lee FS, Ginty DD. 2010. Long-distance control of synapse assembly by target-derived NGF. Neuron 67:422-34. PMCID:PMC2949359.2011Alberi L, Liu S, Wang Y, Badie R, Smith-Hicks C, Wu J, Pierfelice TJ, Abazyan, B, Mattson MP, Kuhl D, Pletnikov M, Worley PF, Gaiano N. 2011. Activity-induced Notch signaling in neurons requires Arc/Arg3.1 and is essential for synaptic plasticity in hippocampal networks. Neuron 69:437-44. PMCID:PMC3056341.Ayhan Y, Abazyan B, Nomura J, Kim R, Ladenheim B, Krasnova IN, Sawa A, Margolis RL, Cadete JL, Mori S, Vogel MW, Ross CA, Pletnikov MV. 2011. Differential effects of prenatal and postnatal expressions of mutant human DISC1 on neurobehavioral phenotypes in transgenic mice: evidence for neurodevelopmental origin of major psychiatric disorders. Mol Psychiatry 16:293-306. PMCID:PMC2914807.Chang MC, Park JM, Pelkey KA, Grabenstatter HL, Xu D, Linden DJ, Sutula TP, McBain CJ, Worley PF. 2011. Narp regulates homeostatic scaling of excitatory synapses on parvalbumin-expressing interneurons. Nat Neurosci 13:1090-7. PMCID:PMC2949072.Chiang PM, Wong PC. 2011. Differentiation of an embryonic stem cell to hemogenic endothelium by defined factors: essential role of bone morphogenetic protein 4. Development 138:2833-43. PMCID:PMC3109605.Guo T, Mandai K, Condie BG, Wickramasinghe SR, Capecchi MR, Ginty DD. 2011. ?An evolving NGF-Hoxd1 signaling pathway mediates development of divergent neural circuits in vertebrates. Nat Neurosci 14:31-6. PMCID:PMC3180918.Harrington AW, St Hillaire C, Zweifel LS, Glebova NO, Philippidou P, Halegoua S, Ginty DD. 2011. Recruitment of actin modifiers to TrkA endosomes governs retrograde NGF signaling and survival. ?Cell 146:421-34. PMCID:PMC3262169.Katsel P, Tan W, Abazyan B, Davis KL, Ross C, Pletnikov MV, Haroutunian V. 2011. Expression of mutant human DISC1 in mice supports abnormalities in differentiation of oligodendrocytes. Schizophr Res 130:238-49. PMCID:PMC3139741.Kristensen AS, Jenkins MA, Banke TG, Schousboe A, Makino Y, Johnson RC, Huganir RL, Traynelis SF. 2011. Mechanism of Ca2+/calmodulin-dependent kinase II regulation of AMPA receptor gating. Nat Neurosci 14:727-35. PMCID:PMC3102786.Makuch L, Volk L, Anggono V, Johnson RC, Yu Y, Duning K, Kremerskothen J, Xia J, Takamiya K, Huganir RL. 2011. Regulation of AMPA receptor function by the human memory-associated gene KIBRA. Neuron 71:1022-9. PMCID:PMC3200575.Matsuoka RL, Chivatakarn O, Badea TC, Samuels IS, Cahill H, Katayama K, Kumar SR, Suto F, Chedotal A, Peachey NS, Nathans J, Yoshida Y, Giger RJ, Kolodkin AL. 2011. Class 5 transmembrane semaphorins control selective mammalian retinal lamination and function. Neuron 71:460-73. PMCID:PMC3164552.Pogorelov VM, Nomura J, Kim J, Kannan G, Ayhan Y, Yang C, Taniguchi Y, Abazyan B, Valentine H, Krasnova IN, Kamiya A, Cadet JL, Wong DF, Pletnikov MV. 2011. Mutant DISC1 affects methamphetamine-induced sensitization and conditioned place preference: a comorbidity model. Neuropharmacol 62:1242-51. PMCID:PMC3115479.Zou J, Zhou L, Du XX, Ji Y, Xu J, Tian J, Jiang W, Zou Y, Yu S, Gan L, Luo M, Yang Q, Cui Y, Yang W, Xia X, Chen M, Zhao X, Shen Y, Chen PY, Worley PF, Xiao B. 2011. Rheb1 is required for mTORC1 and myelination in postnatal brain development. Dev Cell 20:97-108. PMCID:PMC3056331.2012Hu JH, Yang L, Kammermeier PJ, Moore CG, Brakeman PR, Tu J, Yu S, Petralia RS, Li Z, Zhang PW, Park JM, Dong X, Xiao B, Worley PF. 2012. Preso1 dynamically regulates group I metabotropic glutamate receptors. Nat Neurosci 15:836-44. PMCID:PMC3434267.Jun AS, Meng H, Ramanan N, Matthaei M, Chakravarti S, Bonshek R, Black GC, Grebe R, Kimos M. 2012. An alpha 2 collagen VIII transgenic knock-in mouse model of Fuchs endothelial corneal dystrophy shows early endothelial cell unfolded protein response and apoptosis. Hum Mol Genet 21:384-93. PMCID:PMC3276279.?Matthaei M, Meng H, Meeker AK, Eberhart CG, Jun AS. 2012. Endothelial Cdkn1a (p21) overexpression and accelerated senescence in a mouse model of Fuchs endothelial corneal dystrophy. Invest Ophthalmol Vis Sci 53: 6718-27. PMCID:PMC3462481.2013Copley CO, Duncan JS, Liu C, Cheng H, Deans MR. 2013. Postnatal refinement of auditory hair cell planar polarity deficits occurs in the absence of vangl2. J Neurosci 33:14001-16. PMCID:PMC3756750.Engelhard C, Sarsfield S, Merte J, Wang Q, Li P, Beppu H, Kolodkin AK, Sucov HM, Ginty DD. 2013. MEGF8 is a modifier of BMP signaling in trigeminal sensory neurons. eLife 2e01160. ?PMCID:PMC3776557.Hughes EG, Kang SH, Fukaya M, Bergles DE. 2013. Oligodendrocyte progenitors balance growth with self-repulsion to achieve homeostasis in the adult brain. Nat Neurosci 16:668-76. PMCID:PMC3807738.Kim EC, Meng H, Jun AS. 2013. Lithium treatment increases endothelial cell survival and autophagy in a mouse model of Fuchs endothelial corneal dystrophy. Br J Ophthalmol 97:1068-73. PMCID:PMC3793892.Matthaei M, Hu J, Meng H, Lackner EM, Eberhart CG, Qian J, Hao H, Jun AS. ?2013. Endothelial cell whole genome expression analysis in a mouse model of early-onset Fuchs' endothelial corneal dystrophy. Invest Ophthalmol Vis Sci 54:1931-40. PMCID:PMC3604908.Meng H, Matthaei M, Ramanan N, Grebe R, Chakravarti S, Speck CL, Kimos M, Vij N, Eberhart CG, Jun AS. 2013. L450W and Q455K Col8a2 knock-in mouse models of Fuchs endothelial corneal dystrophy show distinct phenotypes and evidence for altered autophagy. Invest Ophthalmol Vis Sci 54:1887-97. PMCID:PMC3626522.Volk LJ, Bachman JL, Johnson R, Yu Y, Huganir RL. 2013. PKM-ζ is not required for hippocampal synaptic plasticity, learning and memory. Nature 493:420-3.PMCID:PMC3830948.?2014Avtanski D, Novaira HJ, Wu S, Romero CJ, Kineman R, Luque RM, Wondisford F, Radovick S. 2014. Both estrogen receptor α and β stimulate pituitary GH gene expression. Mol Endocrinol 28:40-52. PMCID:PMC3874459.Kim EC, Meng H, Jun AS. 2014. N-acetylcysteine increases corneal endothelial cell survival in a mouse model of Fuchs endothelial corneal dystrophy. Exp Eye Res 127:20-5. PMCID:PMC4174697.Kim Y, Chu Y, Han L, Li M, Li Z, Sun S, LaVinka PC, Tang, Z, Park K, Caterina M, Dobner R, Wei F, Dong X. 2014 Central terminal sensitization of TRPV1 by descending serotonergic facilitation modulates chronic pain. Neuron 81:873-887. PMCID:PMC3943838.Li L, Ginty DD. 2014. The structure and organization of lanceolate mechanosensory complexes at mouse hair follicles. Elife:3:e01901. PMCID:PMC3930909.Mandai K, Reimert DV, Ginty DD.2014 Linx mediates interaxonal interactions and formation of the internal capsule. Neuron 83:930103. PMCID:PMC24930700.McNeil B, Pundir P, Meeker S, Han L, Undem B, Kulka M, Dong X. In press. ?Identification of a mast cell specific receptor crucial for pseuro-allergic drug reactions. Nature. PMC Journal – in process.Novaira HJ, Sonko ML, Hoffman G, Koo Y, Ko C, Wolfe A, Radovick S. 2014. Disrupted kisspeptin signaling in GnRH neurons leads to hypogonadotrophic hypogonadism. Mol Endocrinol 28:225-38. PMCID:PMC3896637.Pak T, Yoo S, Miranda-Angulo AM, Wang H, Blackshaw S. 2014. Rax-CreERT2 knock-in mice: a tool for selective and conditional gene deletion in progenitor cells and radial glia of the retina and hypothalamus. PLos One 9:e90381. PMCID:PMC3974648Salvatierra J, Lee D, Zibetti C, Duran-Moreno M, Yoo S, Newman E, Wang H, Bedont J, de Melo J, Miranda-Angulo A, Gil-Perotin S, Garcia-Verdugo JM, and Blackshaw S. In press. The LIM homeodomain factor Lhx2 is required for hypothalamic tanycyte specification and differentiation. 2014. J Neurosci 10:16809-20. PMCID:PMC24261103.Song WJ, Mondal P, Wolfe A, Alonso LC, Stamateris R, Ong BW, Lim OC, Yang KS, Radovick S, Novaira HJ, Farber EA, Farber CR, Turner SD, Hussain MA. 2014. Glucagon regulates hepatic kisspeptin to impair insulin secretion. Cell Metab 19:667-81. PMCID:PMC4058888. ................
................

In order to avoid copyright disputes, this page is only a partial summary.

Google Online Preview   Download