Black Box Warnings A to Z

Black Box Warnings

A to Z

Emory S. Martin III, PharmD BCPS

Vice President, Pharmacy Services

Scott & White Healthcare

1

Objectives

Following the presentation, the participant will: ? Be able to quantify the typical frequency of

prescribing drugs that have a black box warning (BBW) ? Be able to list the common categories of prescribing practices in violation of BBWs ? Be able to navigate and use the FDA's on-line tool for communicating new drug safety information ? Be able to identify 10 significant BBW drugs and how to avoid the BBWs

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INTRODUCTION

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What is a BBW?

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BBW ? More than a Precaution; Less than a Contraindication

US FDA Labeling Cautions ? Precaution: Consideration must be taken in special

situations/patient groups ? Warning: Serious adverse events that have been

observed and potential safety hazards ? A "Black Box Warning" or "Boxed Warning" is the

strongest warning the FDA issues ? Contraindication: Drug should not be used in a

specific situation because risk much greater than possible benefit

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