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Thank you for contacting Sage Products’ Medical / Clinical Science Liaison Department regarding the 2% Chlorhexidine Gluconate* Cloth (*equivalent to 500mg chlorhexidine gluconate per cloth). Please click on the link(s) below or the attachments in this email to view the document(s) you requested:
Journal Resources:
Batra R, et al. Efficacy and Limitation of a Chlorhexidine-Based Decolonization Strategy in Preventing Transmission of Methicillin-Resistant Staphylococcus aureus in an Intensive Care Unit. Clinical Infectious Diseases. 2010 Jan; 15:50(2):218-20
Dudeck, et al. National Healthcare Safety Network (NHSN) Report, Data Summary for 2009, Device-associated Module. AJIC. 2011 June; 39(5):349-367.
Evans H, et al. Effect of Chlorhexidine Whole-Body Bathing on Hospital-Acquired Infections Among Trauma Patients. Arch Surg. 2010 Mar; 145(3):240-6.
Holder C, Zellinger M. Daily Bathing with Chlorhexidine in the ICU to Prevent Central Line-Associated Bloodstream Infections. Journal of Clinical Outcomes Management. 2009 Nov; 16(11):509-13.
Johnson, et al. Patients' Bath Basins as Potential Sources of Infection: A Multicenter Sampling Study. Am J Crit Care. 2009 Jan; 18(1): 31-40.
Milstone A, et al.Chlorhexidine: Expanding the Armamentarium for Infection Control and Prevention, Clinical Infectious Diseases. 2008 Jan; 46:274-81.
Munoz-Price, et al. Successful Control of an Outbreak of Klebsiella pneumonia Carbapenemase–Producing K. pneumonia at a Long-Term Acute Care Hospital. Infection Control and Hospital Epidemiology. 2010 Apr; 31(4): 341-347.
Munoz-Price, et al. Prevention of Bloodstream Infections by Use of Daily Chlorhexidine Baths for Patients at a Long-Term Acute Care Hospital. Infection Control and Hospital Epidemiology. 2009 Nov; 30(11): 1,031-1,035.
Peterson LR, Singh K. Universal patient disinfection as a tool for infection control: rub-a-dub-dub, no need for a tub. Arch Intern Med. 2006 Feb; 166(3):274-6.
Popovich K, et al. Effectiveness of Routine Patient Cleansing with Chlorhexidine Gluconate for Infection Prevention in the Medical Intensive Care Unit. Infection Control & Hospital Epidemiology. 2009 Oct; 30(10):959-63.
Stone P, et al. Systematic Review of Economic Analyses of Health-care Associated Infection. American Journal of Infection Control. 2005 Nov; Vol. 33 No. 9.
Please note: The following study was supported by grants from Sage Products, Inc., Cary, IL and the Centers for Disease Control and Prevention, Atlanta, GA.
Vernon MO, Hayden MK, Trick WE, Hayes RA, Blom DW, Weinstein RA. Chlorhexidine Gluconate to Cleanse Patients in a Medical Intensive Care Unit - The Effectiveness of Source Control to Reduce the Bioburden of Vancomycin-Resistant Enterococci. Arch Intern Med. 2006 Feb; 166(3):306-12.
Please note: The following study was supported by grants from Sage Products, Inc., Cary, IL and the Centers for Disease Control and Prevention, Atlanta, GA.
Bleasdale SC, et al. Effectiveness of Chlorhexidine Bathing to Reduce Catheter-Associated Bloodstream Infections in Medical Intensive Care Unit Patients. Arch Intern Med. 2007 Oct; 167(19):2073-9.
Other Clinical Resources:
Kleinpell R. Can We Discard the Traditional Soap and Basin Bath? Medscape April 2010
Popovich K, et al. Correlation between Results of a Semi-quantitative Chlorhexidine Gluconate (CHG) Indicator Test and Gram-positive Colony Counts (CFU) on Skin of Medical Intensive Care Unit (MICU) Patients Bathed Daily with CHG. Poster Presentation at ICAAC 2007.
Rosselet R, et al. CHG Waterless Bath System Significantly Reduced BSI in Pediatric BMT Patients. Poster Presentation at ASBMT 2009.
Stokowski L. CHG in Healthcare: Your Questions Answered. Medscape Aug 2010
|Please note, the Food and Drug Administration has approved a New Drug Application submitted by Sage Products, Inc. for use of the 2% |
|Chlorhexidine Gluconate (CHG) Cloth (*equivalent to 500mg chlorhexidine per cloth) for the indication, "Patient Preoperative Skin |
|Preparation." |
| |
|The information contained in the documents listed above concerns a use of the 2% CHG Cloth that has not been approved by the FDA. An |
|unapproved (off-label) use of the 2% CHG Cloth is investigational and therefore may not be eligible for reimbursement. |
| |
|This information is being disseminated at the expense of Sage Products, Inc. Questions regarding use of the 2% CHG Cloth as described in the|
|documents listed above must be addressed only by Sage Products' Medical Science Liaison Department, at 800 323 2220. |
The following are available in abstract view only:
Climo, et al. The Effect of Daily Bathing with Chlorhexidine on the Acquisition of Methicillin-resistant Staphylococcus aureus, Vancomycin-resistant Enterococcus, and Healthcare-associated Bloodstream Infections: Results of a Quasi-experimental Multicenter Trial. Crit Care Med. 2009 Jun; 37(6):1,858-65.
Dixon, et al. Daily Chlorohexidine Gluconate Bathing with Impregnated Cloths Results in Statistically Significant Reduction in Central Line-associated Bloodstream Infections. Am J Infect Control. 2010 Dec; 38(10):817-21.
Eigsti et al. Innovative Solutions: Beds, Baths, and Bottoms: A Quality Improvement Initiative to Standardize Use of Beds, Bathing Techniques, and Skin Care in a General Critical-Care Unit. Dimens Crit Care Nurs. 2011 May; 30(3):169-176.
Kassakian. Impact of Chlorhexidine Bathing on Hospital-acquired Infections Among General Medical Patients. Infect Control Hosp Epidemiol. 2011 Mar;32(3):238-43.
Lee, et al. Blood Concentrations of Chlorhexidine in Hospitalized Children Undergoing Daily Chlorhexidine Bathing. Infect Control Hosp Epidemiol. 2011 Apr; 32(4):395-7.
Lopez, et al. A Quality Improvement Program Combining Maximal Barrier Precaution Compliance Monitoring and Daily Chlorhexidine Gluconate Baths Resulting in Decreased Central Line Bloodstream Infections. Dimens Crit Care Nurs. 2011 Sep; 30(5):293-298.
Ober, et al. Interventions to Reduce UTIs in the Critical Care Setting. SHEA, International Conference on Healthcare Associated Infections. 2010 Mar.
Popovich, et al. Daily Skin Cleansing with Chlorhexidine did not Reduce the Rate of Central-line Associated Bloodstream Infection in a Surgical Intensive Care Unit. Intensive Care Med. 2010 May; 36(5):854-8.
Shannon, et al. Economics of Central Line-Associated Bloodstream Infections. Am J Med Qual. 2006 Nov/Dec; 21(6 Suppl): 7S-16S.
Umscheid, et al. Estimating the Proportion of Healthcare-Associated Infections That are Reasonably Preventable and the Related Mortality and Costs. Infect Control Hosp Epidemiol. 2011 Feb; 32(2):101-14.
Additional documents:
Sage 2% Chlorhexidine Gluconate* (CHG) Cloth: Summary of Time Kill and MIC Testing for 2% Chlorhexidine Gluconate Solution
Chlorhexidine Gluconate (CHG) Compatibility
Expert Opinion: Irritancy Testing 2% Chlorhexidine Gluconate (CHG) Cloth
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