Sample Size Calculation in Clinical Research
[Pages:10]Lecture 4
Sample Size Calculation in Clinical Research
Overview
Basic Considerations Comparing Means Comparing Proportions Comparing Time-to-event Data Genomics Summary
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Basic Considerations
Type of Sample Size Calculation Type I error and Power Hypotheses Study Designs Information required Practical Issues
Type of Sample Size Calculation
Sample Size Calculation/Estimation or Determination
Sample Size Justification Sample Size Re-estimation Sample Size Adjustment
Type I Error and Power
Sample size is usually selected for achieving a desired power (say 80% chance of correctly detecting a clinically meaningful difference) at a pre-specified significance level (say 5%)
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