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Supplement S1. Search Strategy for the overview paper The search strategy followed a two-step process. An initial search was developed in Ovid MedLine with a goal to develop the initial group of subject headings and keywords and sent to all authors for review. Once the initial review was considered by the team, additional keywords and subject headings were added to the search to ensure completeness. Only once a satisfactory search was completed in Ovid MedLine were additional databases added and the search translated to Embase and PsycInfo, both using the Ovid platform and CINAHL (Ebsco). Initial searches were conducted in February 2019 and all searches were completed the week of May 6-10, 2019. For searches in MedLine, Embase and CINAHL, the initial topic keywords and subject headings were combined with the Scottish Intercollegiate Guidance Network (SIGN) search filters for reviews (available at: ). The SIGN search filters for reviews was modified for the PsycInfo database by ARW.Resistance Training Search StrategyOvid MedlineOvid EmbaseEbsco CINAHLOvid PsycInfoSubject HeadingsResistance Training/Resistance training/resistance training/ muscle strength/ AND (exercis* or train*).mp. 11 1 or 4 or 5 or 6 or 7 or 8 or 9 or 10 (49475) (MH "MuscleStrengthening") OR (MH"Resistance Training")Keywords(weight bear* or weight lift* or load bear* or axial bear*) adj3 (exercise* or strengthen*)resistance train*strength train*resistance train*.mp.functional strength*.mp.postural control*.mp.functional train*.mp.strength train*.mp. ((weight bear* or weight lift* or load bear* or axial bear*) adj3 (exercise* or strengthen*)).mp.TX "resistance train*"TX "strength train*"TX ((weight bear* orweight lift* or load bear* or axial bear*) N3 (exercise* or strengthen*))TX "functional strength*"TX "functional train*"TX "postural control*"(weight bear* or weight lift* or load bear* or axial bear*) adj3 (exercise* or strengthen*)resistance train*strength train*SIGN review1. Meta-Analysis as Topic/2. meta analy$.tw.3. metaanaly$.tw.4. Meta-Analysis/5. (systematic adj (review$1 or overview$1)).tw.6. exp Review Literature as Topic/7. or/1-68. cochrane.ab.9. embase.ab.10. (psychlit or psyclit).ab.11. (psychinfo or psycinfo).ab.12. (cinahl or cinhal).ab.13. science citation index.ab.14. bids.ab.15. cancerlit.ab.16. or/8-1517. reference list$.ab.18. bibliograph$.ab.19. hand-search$.ab.20. relevant journals.ab.21. manual search$.ab.22. or/17-2123. selection criteria.ab.24. data extraction.ab.25. 23 or 2426. Review/27. 25 and 2628. Comment/29. Letter/30. Editorial/31. animal/32. human/33. 31 not (31 and 32)34. or/28-30,3335. 7 or 16 or 22 or 2736. 35 not 3412 exp Meta Analysis/ 13 ((meta adj analy$) or metaanalys$).tw. 14 (systematic adj (review$ or overview$)).tw. 15 12 or 13 or 14 16 (cancerlit or cochrane or embase or psychlit or psyclit or psychinfo or psycinfo or cinahl or cinhal or "science citation index" or bids).ab. 17 ("reference lists" or bibliograph$ or hand-search$ or "manual search$" or "relevant journals").ab. 18 ("data extraction" or "selection criteria").ab. 19 review.pt.20 18 and 19 21 letter.pt.22 editorial.pt. 23 animal/ 24 human/ 25 23 not (23 and 24) 26 21 or 22 or 25 27 15 or 16 or 17 or 20 28 27 not 26 29 11 and 28 (MH "Meta Analysis")TX "Meta analys*"TX Metaanaly*(MH "Literature Review")OR (MH "ScopingReview") OR (MH"Systematic Review")TX (systematic N1 (reviewor overview))(meta analy$ OR metaanaly$).tw.(systematic adj (review$1 or overview$1)).tw.(cochrane OR embase OR(cinahl or cinhal) ORscience citation index ORbids OR cancerlit ORreference list$ ORbibliograph$ ORhand-search$ OR relevant journals ORmanual search$).abLimitsHumanAdultsEnglish or French2009-presentNOT exp pregnancy/HumanAdultsEnglish or French2009-presentNOT exp pregnancy/ArticleHumanAdultsEnglish or French2009-presentNOT (MH "Pregnancy+")Journal ArticleHumanAdultsEnglish or French2009-presentTOTAL # citations7171735135510Systematic Review Authors Reasons for Exclusion Borde et al. (2015)Casonatto et al. (2016)De Oliveira et al. (2017)Granacher et al. (2013)Grgic et al. (2018)Guizelini et al. (2018)Hortobágyi et al. (2015)Lemes et al. (2016)Liu et al (2017)López-Valenciano et al. (2019)Moran et al. (2018)Raymond et al. (2013)Roig et al. (2009)Schoenfeld et al. (2017)Steib et al. (2010)Missing critical AMSTAR 2 items Carlson et al. (2014)Did not address any of the secondary research questions (e.g., age, exposure dose, or type of RT)Cornelissen et al. (2013)Paterson et al. (2010)Rossi et al. (2013)Not the most recent systematic review available Katsoulis et al. (2019)Missing meta-analysis*Supplement S2. List of excluded systematic reviews and reasons for exclusion when prioritized by outcome. Abbreviations:AMSTAR, A MeaSurement Tool to Assess systematic Reviews; RT, Resistance Training*There were two systematic reviews that examined older adults only and they were both published in the same year and had a “moderate” AMSTAR 2 rating. However, one systematic review performed a meta-analysis and one did not. Therefore, we chose to include the systematic review with the meta-analysis.References: ADDIN Mendeley Bibliography CSL_BIBLIOGRAPHY Borde, R., Hortobágyi, T., & Granacher, U. (2015). Dose–Response Relationships of Resistance Training in Healthy Old Adults: A Systematic Review and Meta-Analysis. Sports Medicine, 1693–1720. , D. J., Dieberg, G., Hess, N. C., Millar, P. J., & Smart, N. A. (2014). Isometric exercise training for blood pressure management: A systematic review and meta-analysis. Mayo Clinic Proceedings, 89(3), 327–334. , J., Goessler, K. F., Cornelissen, V. A., Cardoso, J. R., & Polito, M. D. (2016). The blood pressure-lowering effect of a single bout of resistance exercise: A systematic review and meta-analysis of randomised controlled trials. European Journal of Preventive Cardiology, 23(16), 1700–1714. , V. A., & Smart, N. A. (2013). Exercise training for blood pressure: a systematic review and meta-analysis. Journal of the American Heart Association, 2(1), 1–9. Oliveira, P. A., Blasczyk, J. C., Junior, G. S., Lagoa, K. F., Soares, M., De Oliveira, R. J., … Martins, A. W. R. (2017). Effects of Elastic Resistance Exercise on muscle strength and functional performance in healthy adults: A systematic review and meta-analysis. Journal of Physical Activity and Health, 14(4), 317–327. , U., Gollhofer, A., Hortobágyi, T., Kressig, R. W., & Muehlbauer, T. (2013). The Importance of Trunk Muscle Strength for Balance, Functional Performance, and Fall Prevention in Seniors: A Systematic Review. Sports Medicine, 43(7), 627–641. , J., Schoenfeld, B. J., Davies, T. B., Lazinica, B., Krieger, J. W., & Pedisic, Z. (2018). Effect of Resistance Training Frequency on Gains in Muscular Strength: A Systematic Review and Meta-Analysis. Sports Medicine, 48(5), 1207–1220. , P. C., de Aguiar, R. A., Denadai, B. S., Caputo, F., & Greco, C. C. (2018). Effect of resistance training on muscle strength and rate of force development in healthy older adults: A systematic review and meta-analysis. Experimental Gerontology, 102(June 2017), 51–58. ágyi, T., Lesinski, M., G?bler, M., VanSwearingen, J. M., Malatesta, D., & Granacher, U. (2015). Effects of Three Types of Exercise Interventions on Healthy Old Adults’ Gait Speed: A Systematic Review and Meta-Analysis. Sports Medicine, 45(12), 1627–1643. , K., Stathokostas, L., & Amara, C. E. (2019). The effects of high- versus low-intensity power training on muscle power outcomes in healthy, older adults: A systematic review. Journal of Aging and Physical Activity, 27(3), 422–439. , ?. R., Ferreira, P. H., Linares, S. N., MacHado, A. F., Pastre, C. M., & Netto, J. (2016). Resistance training reduces systolic blood pressure in metabolic syndrome: A systematic review and meta-analysis of randomised controlled trials. British Journal of Sports Medicine, 50(23), 1438–1442. , C. J., Changa, W. P., De Carvalho, I. A., Savagea, K. E. L., Radforda, L. W., & Thiyagarajan, J. A. (2017). Effects of physical exercise in older adults with reduced physical capacity: Meta-analysis of resistance exercise and multimodal exercise. International Journal of Rehabilitation Research, 40(4), 303–314. ópez-Valenciano, A., Ruiz-Pérez, I., Ayala, F., Sánchez-Meca, J., & Vera-Garcia, F. J. (2019). Updated systematic review and meta-analysis on the role of isometric resistance training for resting blood pressure management in adults. Journal of Hypertension, 37(7), 1320–1333. , J., Ramirez-Campillo, R., & Granacher, U. (2018). Effects of Jumping Exercise on Muscular Power in Older Adults: A Meta-Analysis. Sports Medicine, 48(12), 2843–2857. , D. H., & Warburton, D. E. R. (2010). Physical activity and functional limitations in older adults: A systematic review related to Canada’s Physical Activity Guidelines. International Journal of Behavioral Nutrition and Physical Activity, 7. , M. J., Bramley-Tzerefos, R. E., Jeffs, K. J., Winter, A., & Holland, A. E. (2013). Systematic Review of High-Intensity Progressive Resistance Strength Training of the Lower Limb Compared With Other Intensities of Strength Training in Older Adults. Archives of Physical Medicine and Rehabilitation, 94(8), 1458–1472. , M., O’Brien, K., Kirk, G., Murray, R., McKinnon, P., Shadgan, B., & Reid, W. D. (2009). The effects of eccentric versus concentric resistance training on muscle strength and mass in healthy adults: A systematic review with meta-analysis. British Journal of Sports Medicine, 43(8), 556–568. , A. M., Moullec, G., Lavoie, K. L., Gour-Proven?al, G., & Bacon, S. L. (2013). The evolution of a Canadian hypertension education program recommendation: The impact of resistance training on resting blood pressure in adults as an example. Canadian Journal of Cardiology, 29(5), 622–627. , B. J., Grgic, J., Gborn, D., & Krieger, J. W. (2017). Strength and hypertrophy adaptations between low- vs.high-load resistance training: A systematic review and meta-analysis. Journal of Strength and Conditioning Research, 31(12), 3508–3523.Steib, S., Schoene, D., & Pfeifer, K. (2010). Dose-response relationship of resistance training in older adults: A meta-analysis. Medicine and Science in Sports and Exercise, 42(5), 902–914. )00a)-157661852449b)00b)472971570574c)00c)Supplement S3. Meta-analysis of primary studies that met the inclusion criteria for the outcome health related-quality of life. a) No difference in the physical function domains between resistance training and control. b) No difference in vitality between resistance training and control. c) No difference in pain between resistance training and control. Squares represent the weight given to each study in the analysis; larger squares represent bigger weights. Vertical lines represent no effect. Supplement S4. Reference list for the 31 primary studies that met the inclusion criteria for the adverse events outcome. Bean JF, Herman S, Kiely DK, Frey IC, Leveille SG, Fielding RA, et al. Increased Velocity Exercise Specific to Task (InVEST) training: a pilot study exploring effects on leg power, balance, and mobility in community-dwelling older women. Journal of the American Geriatrics Society. 2004; 52(5):799–804. [PubMed: 15086665]Boshuizen HC, Stemmerik L, Westhoff MH, Hopman-Rock M. The effects of physical therapists' guidance on improvement in a strength-training program for the frail elderly. Journal of Aging & Physical Activity. 2005; 13(1):5–22. [PubMed: 15677832]Buchner DM, Cress ME, de Lateur BJ. The effect of strength and endurance training on gait, balance, fall risk and health services use in community-living older adults. Journals of Gerontology Series A-Biological Sciences & Medical Sciences. 1997; 52(4):M218–24.de Vos NJ, Singh NA, Ross DA, Stavrinos TM, Orr R, Fiatarone-Singh MA. Optimal load for increasing muscle power during explosive resistance training in older adults. Journals of Gerontology Series A-Biological Sciences & Medical Sciences. 2005; 60(5):638–47.de Vreede PL, Van Meeteren NL, Samson MM, Wittink HM, Duursma SA, Verhaar HJ. The effect of functional tasks exercise and resistance exercise on health-related quality of life and physical activity: A randomized controlled trial. Gerontology. 2007; 53(1):12–20. [PubMed: 16940735]DeBeliso M, Harris C, Spitzer-Gibson T, Adams KJ. A comparison of periodised and fixed repetition training protocol on strength in older adults. Journal of Science & Medicine in Sport. 2005; 8(2):190–9. [PubMed: 16075779]DiFrancisco-Donoghue J, Werner W, Douris P. Comparison of once-weekly and twice-weekly strength training in older adults. British Journal of Sports Medicine. 2007; 41(1):19–22. [PubMed: 17062657]Fatouros IG, Kambas A, Katrabasas I, Nikolaidis K, Chatzinikolaou A, Leontsini D, et al. Strength training and detraining effects on muscular strength, anaerobic power, and mobility of inactive older men are intensity dependent. British Journal of Sports Medicine. 2005; 39(10):776–80. [PubMed: 16183776]Fielding RA, LeBrasseur NK, Cuoco A, Bean J, Mizer K, Fiatarone Singh MA. High-velocity resistance training increases skeletal muscle peak power in older women. Journal of the American Geriatrics Society. 2002; 50(4):655–62. see comment. [PubMed: 11982665]Galvao DA, Taaffe DR. Resistance exercise dosage in older adults: Single- versus multiset effects on physical performance and body composition. Journal of the American Geriatrics Society. 2005; 53(12):2090–7. [PubMed: 16398892]Harris C, DeBeliso MA, Spitzer-Gibson TA, Adams KJ. The effect of resistance-training intensity on strength-gain response in the older adult. Journal of Strength & Conditioning Research. 2004; 18(4):833–8. [PubMed: 15574091]Haykowsky M, Humen D, Teo K, Quinney A, Souster M, Bell G, et al. Effects of 16 weeks of resistance training on left ventricular morphology and systolic function in healthy men >60 years of age. American Journal of Cardiology. 2000; 85(8):1002–6. [PubMed: 10760343]Haykowsky M, McGavock J, Vonder Muhll I, Koller M, Mandic S, Welsh R, et al. Effect of exercise training on peak aerobic power, left ventricular morphology, and muscle strength in healthy older women. Journals of Gerontology Series A-Biological Sciences & Medical Sciences. 2005; 60(3):307–11.Jones CJ, Rikli RE, Benedict J, Williamson P. Effects of a resistance training program on leg strength and muscular endurance in older women. Scandinavian Journal of Medicine and Science in Sports. 1995; 5(6):329–41. [PubMed: 8775717]Jubrias SA, Esselman PC, Price LB, Cress ME, Conley KE. Large energetic adaptations of elderly muscle to resistance and endurance training. Journal of Applied Physiology. 2001; 90(5):1663–70. [PubMed: 11299253]Judge JO, Whipple RH, Wolfson LI. Effects of resistance and balance exercises on isokinetic strength in older persons. Journal of the American Geriatrics Society. 1994; 42(9):937–46. [PubMed: 8064101]Kallinen M, Sipila S, Alen M, Suominen H. Improving cardiovascular fitness by strength or endurance training in women aged 76-78 years. A population-based, randomized controlled trial. Age and Ageing. 2002; 31(4):247–54. [PubMed: 12147561]Macaluso A, Young A, Gibb KS, Rowe DA, De Vito G. Cycling as a novel approach to resistance training increases muscle strength, power, and selected functional abilities in healthy older women. Journal of Applied Physiology. 2003; 95(6):2544–53. [PubMed: 12937026]McCartney N, Hicks AL, Martin J, Webber CE. Long-term resistance training in elderly: Effects on dynamic strength, exercise capacity, muscle and bone. Journals of Gerontology Series A-Biological Sciences & Medical Sciences. 1995; 50(2):B97–104.Miszko TA, Cress ME, Slade JM, Covey CJ, Agrawal SK, Doerr CE. Effect of strength and power training on physical function in community-dwelling older adults. Journals of Gerontology Series A-Biological Sciences & Medical Sciences. 2003; 58(2):171–5.Nelson ME, Fiatarone MA, Morganti CM, Trice I, Greenberg RA, Evans WJ. Effects of high-intensity strength training on multiple risk factors for osteoporotic fractures. JAMA. 1994; 272(24):1909–14. [PubMed: 7990242]Nichols JF, Omizo DK, Peterson KK, Nelson KP. Efficacy of heavy-resistance training for active women over sixty: Muscular strength, body composition and program adherence. Journal of the American Geriatrics Society. 1993; 41(3):205–10. [PubMed: 8440838]Pollock ML, Carroll JF, Graves JE, Leggett SH, Braith RW, Limacher M, et al. Injuries and adherence to walk/jog and resistance training programs in the elderly. Medicine & Science in Sports & Exercise. 1991; 23(10):1194–200. [PubMed: 1758297]Schlicht, J. Effect of intense strength training on walking speed, standing balance and sit-to-stand performance in older adults [thesis]. Storrs (CT): Univ. of Connecticut; 1999.Simons R, Andel R. The effects of resistance training and walking on functional fitness in advanced old age. Journal of Aging & Health. 2006; 18(1):91–105. [PubMed: 16470977]Skelton DA, Young A, Greig CA, Malbut KE. Effects of resistance training on strength, power, and functional abilities of women aged 75 and older. Journal of the American Geriatrics Society. 1995; 43(10):1081–7. [PubMed: 7560695]Skelton DA, McLaughlin AW. Training functional ability in old age. Physiotherapy. 1996; 82(3):159–67.Symons TB, Vandervoort AA, Rice CL, Overend TJ, Marsh GD. Effects of maximal isometric and isokinetic resistance training on strength and functional mobility in older adults. Journals of Gerontology Series A-Biological Sciences & Medical Sciences. 2005; 60(6):777–81.Vincent KR, Braith RW, Feldman RA, Magyari PM, Cutler RB, Persin SA, et al. Resistance exercise and physical performance in adults aged 60 to 83. Journal of the American Geriatrics Society. 2002; 50(6):1100–7. [PubMed: 12110072]Jette AM, Lachman M, Giorgetti MM, Assman SF, Harris BA, Levenson C, et al. Exercise - it's never too late: The strong-for-life program. American Journal of Public Health. 1999; 89(1):66–72. [PubMed: 9987467]Krebs DE, Scarborough DM, McGibbon CA. Functional vs. strength training in disabled elderly outpatients. American Journal of Physical Medicine & Rehabilitation. 2007; 86(2):93–103. [PubMed: 17251692] ................
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