Welcome to the Institute for Translational Medicine and ...



How to Navigate Research Resources at Penn

Symposium for Early Investigators

Friday, December 11, 2009

Shared Resources

Ian A. Blair, Ph.D. (ianblair@mail.med.upenn.edu)

What research cores are available to me and how do I access them?

A. Abramson Cancer Center (ACC)

Center for Cancer Pharmacology (CCP)

Center of Excellence in Environmental Toxicology (CEET)

Institute for Translational Medicine and Therapeutics (ITMAT)

Penn Genome Frontiers Institute (PGFI)

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Abramson Cancer Center Proteomics Core:

Shared Resources/Core Facilities

The Cancer Center supports 12 NCI-approved Shared Resources to provide investigators with easy access to state-of-the-art research technology, equipment, and technical support that would otherwise be too difficult or expensive for individual investigat ors or programs to develop. The availability of these core research facilities significantly increases the ease with which cancer-related research can be conducted on the campus.

1. Biomedical Imaging Core

Biomedical Informatics Core

Biostatistics Unit

Clinical Cell and Vaccine Production Facility

Clinical Research Unit

DNA Sequencing Facility

Flow Cytometry and Cell Sorting Facility

Histology Service Core

Human Immunology Core

Melanoma Core

Microarray Facility

Molecular Diagnosis & Genotyping Facility

Proteomics Core

Recruitment, Outcomes, and Assessment Resource

Small Animal Imaging Core

Stem Cell and Xenograft Core

Transgenic and Chimeric Mouse Facility

Tumor Tissue Bank

Center for Cancer Pharmacology (CCP) Proteomics Core Facility:

Proteomics Core Facility

The mission of the Proteomics Facility is to provide and disseminate state-of-the-art scientific and technical knowledge in proteomics that will contribute to the research programs of investigators at the University of Pennsylvania and the Children's Hospital of Philadelphia.

This will be accomplished by exploiting and evaluating the impacts of discoveries in proteomics, through focused efforts in:

1. instrumentation

2. protein separation and detection

3. bioinformatics

4.

The Facility is an integral component of the Genomics Institute.

The Proteomics Facility Office

853 BRB II/III

The Proteomics Facility

838 BRB II/III

Philadelphia, PA 19104-6160

215.573.9883 Tel 215.573.9889 Fax

Chao-Xing Yuan, Ph.D. 852 BRB II/III

Christine Busch 838 BRB II/III

Data Processing Room Proteomics Facility 851 BRB II/III

Services provided by the Proteomics Core Facility include:

1. 2D gel electrophoresis

2. Ettan DIGE analysis

3. Applied Biosystems Voyager Pro DE MALDI-TOF mass spectrometer for peptide mass measurement

4. LCQ Deca XP Plus mass spectrometer for peptide sequencing

Center of Excellence in Environmental Toxicology (CEET):

Facility Cores

Molecular Profiling Facility Core

The Molecular Profiling Core (MPC) was formed in April 2008 to provide CEET investigators with the resources to conduct integrated “omics” and biomarker research related to toxicant exposure and response. This was accomplished by combining the resources of the existing Toxicogenomics, Toxicoproteomics, and Biomarker Facility Cores into a single Facility Core. Each of these individual areas has a dedicated Technical Director who has considerable expertise in the application of the relevant technology to toxicology research. The MPC provides an integrated systems biology approach to identify molecular fingerprints of exposure and response.

Facility Service

Toxicogenomics

|Technical Director, Toxicogenomics : Don Baldwin |dbaldwin@mail.med.upenn.edu |  |

|Technical Director, Bioinformatics::  John Tobias |jtobias@pcbi.upenn.edu |  |

Request Toxicogenomics Consultation (You must indicate whether you are a CEET member in your request to gain priority access (dbaldwin@mail.med.upenn.edu )

The mission of the Toxicogenomics component of the Molecular Profiling Core is to foster both basic and translational research into environmental health science within the CEET. Existing institutionally supported genomics resources have been expanded to provide coordinated, focused support for environmental toxicology projects in the CEET. This is accomplished by providing scientific consultation, instrumentation, and technical expertise for high throughput RNA transcript profiling, high-throughput genotyping, massively parallel sequencing, and toxicogenomic data analysis.

Services Available

• Target Preparation and Sequencing

• Massively Parallel Sequencing

• Quantitative PCR

• Custom Multiplex Genotyping

• Whole Genome Profiling

• Transcript Profiling

• DNA Profiling

• Molecular Diagnosis and Genotyping

• Bioinformatics and Data Analysis

• Quality Control for User Projects

Institute for Translational Medicine and Therapeutics (ITMAT):

Core Facilities

Cores housed within ITMAT are designed to address infrastructural barriers to clinical and translational research. These cores exist to deliver service and typically have a cost sharing structure that enables their expansion and development.

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• » Automated Claims and Automated Medical Record Databases (ACARD)

• » Bioinformatics Facility

• » Community Based Research Core (CBRC)

• » Community Outreach using Health System Informatics (COHSI)

• » Dissemination of Translation (DOT)

• » Investigational Drug Service (IDS)

• » Kinetics Modeling and Simulation (KMAS)

• » Office of Human Subject Advocacy and Protection (OHSAP)

• » Outcomes Measurement Methods Core (OMMC)

• » Proteomics Core

• » Recruitment and Coordination Core (RCC)

• » Research Nurse Core (RNC)

• » Study Design and Biostatistics (SDAB)

• » Translational and Clinical Trial Organization (TACTO)

• » Translational Core Lab (TCL)

Penn Genome Frontiers Institute (PGFI):



Proteomics

The Proteomics Facility, an integral component of the Penn Genome Frontiers Institute, provides and disseminates state-of-the-art scientific and technical knowledge in proteomics.

Dr. Ian A. Blair, Scientific Director

ianblair@mail.med.upenn.edu

853 BRB II/III/ Office

838 BRB II/III/ Facility

421 Curie Blvd.

Philadelphia, PA 19104-6160

215-573-9880

215-573-9889 (fax)

Dr. Chao-Xing Yuan, Technical Director

yuancx@mail.med.upenn.edu

215-573-9883

215-573-9889



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