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Phylogenetic analysis of cell-cycle regulatory proteins within the SymbiodiniaceaeLucy M. Gorman1, Shaun P. Wilkinson1, Sheila A. Kitchen2, Clinton A. Oakley1, Arthur R. Grossman3, Virginia M. Weis4, Simon K. Davy1*1School of Biological Sciences, Victoria University of Wellington, Wellington 6140, New Zealand 2 Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California 91125, United States3Department of Plant Biology, The Carnegie Institution for Science, Stanford, California 94305, United States4Department of Integrative Biology, Oregon State University, Corvallis, Oregon 97331, United States *Corresponding author: Simon.Davy@vuw.ac.nzFigure S1. A. Residues 1-10 of trained cyclin pHMM model for querying Symbiodiniaceae databases. B. Residues 1-10 of trained cyclin-dependent kinase pHMM model for querying Symbiodiniaceae databases. Black horizontal bars represent the likelihood of an amino acid appearing at that residue. Match states are shown as rectangles, insert states as diamonds, and delete states as circles. Numbers in the delete states are simply model module numbers, while those in the insert states are the probabilities of remaining in the current insert state at the next emission cycle. Lines are weighted and directed where necessary to reflect the transition probabilities between states. The large “B” label is the silent begin state of the model.Figure S2. Full phylogenetic tree of CDKs within Symbiodiniaceae. Colour of branches corresponds to aLRT support (SH-value). Purple branches correspond to SH-values below 0.5, brown branches correspond to SH-values near 0.5, and green branches correspond to SH-values close to 1. Symbiodiniaceae species are written in blue. 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Full phylogenetic tree of cyclins within Symbiodiniaceae. Colour of branches corresponds to aLRT support (SH-value). Purple branches correspond to SH-values below 0.5, brown branches correspond to SH-values near 0.5, and green branches correspond to SH-values close to 1. Symbiodiniaceae species are written in blue. 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tolerances","type":"article-journal","volume":"33"},"uris":[""]}],"mendeley":{"formattedCitation":"32","plainTextFormattedCitation":"32","previouslyFormattedCitation":"32"},"properties":{"noteIndex":0},"schema":""}32>C1MI_TR62820_c0_g1_i2_m.149847LAPRPPAARLDNPVSHQELTNNNCCKKRRSSFLLHHTMSRYEKIEKVGEGTFGVVYKAKDRQTGELVALKRMRLEAEEEGIPCTAIREISLLKELRHDNVVRLHDVVHSDRKLTLVFEFLQMDLRDYMDKAGEGGLDPWSVQHFMRQLLLGIEYCHYRMVLHRDLKPQNLLISRDRVLKLADFGLGRAFEIPVHRMTHDVVTLWYRPPDVLLGSTKYSCNIDIWSAGCIFAEMAIGHALFNGRNDSDQLLKIFTFLGTPTQTEWPSMMDCPHSSAMLARDALHESFKTKSVEDLLAMGGGFETLGALGCDLLLKMLQYEPQRRLCASEALAHPYFQQRL*Table S5. Selected unicellular marine organisms databases used for screening through for CDKs and cyclins. TaxaSpeciesSource of DatabaseFree-living/Symbiotic/ParasiticHeterotroph or photosyntheticDinoflagellateAlexandrium fundyenseMMETSPFree-livingPhotosyntheticAlexandrium monilatumFree-livingPhotosyntheticLingulodinium polyedra Free-livingPhotosyntheticKarenia brevis Free-livingPhotosyntheticAmphidinium carteceaFree-livingPhotosyntheticAmphidiniumFree-livingPhotosyntheticPeridinium aciculiferum Free-livingPhotosyntheticPelagodinium beiSymbioticPhotosyntheticKryptoperdinium foliaceumFree-livingPhotosyntheticAmoebophyra sp. ParasiticHeterotrophBrandtodinium nutriculaSymbioticPhotosyntheticPolarella glacialis Free-livingPhotosyntheticCeratium fususFree-livingPhotosyntheticAnsanella graniferaEnsembl SADDIN CSL_CITATION {"citationItems":[{"id":"ITEM-1","itemData":{"ISSN":"1874-7787","author":[{"dropping-particle":"","family":"Jang","given":"Se Hyeon","non-dropping-particle":"","parse-names":false,"suffix":""},{"dropping-particle":"","family":"Jeong","given":"Hae Jin","non-dropping-particle":"","parse-names":false,"suffix":""},{"dropping-particle":"","family":"Chon","given":"Jae Kyung","non-dropping-particle":"","parse-names":false,"suffix":""},{"dropping-particle":"","family":"Lee","given":"Sung Yeon","non-dropping-particle":"","parse-names":false,"suffix":""}],"container-title":"Marine genomics","id":"ITEM-1","issued":{"date-parts":[["2017"]]},"page":"47-55","title":"De novo assembly and characterization of the transcriptome of the newly described dinoflagellate Ansanella granifera: Spotlight on 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RNA-seq data taken from Maor‐Landaw et al.SADDIN CSL_CITATION {"citationItems":[{"id":"ITEM-1","itemData":{"ISSN":"2045-7758","author":[{"dropping-particle":"","family":"Maor‐Landaw","given":"Keren","non-dropping-particle":"","parse-names":false,"suffix":""},{"dropping-particle":"","family":"Oppen","given":"Madeleine J H","non-dropping-particle":"van","parse-names":false,"suffix":""},{"dropping-particle":"","family":"McFadden","given":"Geoffrey I","non-dropping-particle":"","parse-names":false,"suffix":""}],"container-title":"Ecology and Evolution","id":"ITEM-1","issue":"1","issued":{"date-parts":[["2020"]]},"page":"451-466","publisher":"Wiley Online Library","title":"Symbiotic lifestyle triggers drastic changes in the gene expression of the algal endosymbiont Breviolum minutum (Symbiodiniaceae)","type":"article-journal","volume":"10"},"uris":[""]}],"mendeley":{"formattedCitation":"40","plainTextFormattedCitation":"40","previouslyFormattedCitation":"40"},"properties":{"noteIndex":0},"schema":""}40 of Breviolum minutum CDKs and cyclins that are differentially expressed (log2 fold-change) in free-living versus symbiotic states that correspond to CDK and cyclin proteins found in our study. Values < 0 indicate a down-regulation in expression, whereas values > 0 indicate an up-regulation in expression. Symbiodiniaceae genelog2 fold-changeAdjusted p-valueP/U-type Cyclin 10.34<0.001P/U-type Cyclin 2-0.54<0.001CDKB10.3670.0019CDKB20.355< 0.0001CDKC-0.6457< 0.0001CDKF0.9921< 0.0001CDKG0.3980.01289CDKH0.697< 0.0001CDKI-0.23090.0026CDK7-related protein0.3630.0135CDK90.18170.03014ReferencesSADDIN Mendeley Bibliography CSL_BIBLIOGRAPHY 1.Guindon, S. & Gascuel, O. A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood. Syst. Biol. 52, 696–704 (2003).S2.Letunic, I. & Bork, P. Interactive Tree Of Life (iTOL) v4: recent updates and new developments. Nucleic Acids Res. 47, 256–259 (2019).S3.Gavet, O. & Pines, J. Activation of cyclin B1-CDK1 synchronizes events in the nucleus and the cytoplasm at mitosis. J. Cell Biol. 189, 247–259 (2010).S4.Atikukke, G., Albosta, P., Zhang, H. & Finley Jr, R. L. A role for Drosophila Cyclin J in oogenesis revealed by genetic interactions with the piRNA pathway. Mech. Dev. 133, 64–76 (2014).S5.Yam, C. H., Fung, T. K. & Poon, R. Y. C. Cyclin A in cell-cycle control and cancer. Cell. Mol. Life Sci. C. 59, 1317–1326 (2002).S6.Malumbres, M. & Barbacid, M. Cell cycle, CDKs and cancer: a changing paradigm. Nat. Rev. Cancer 9, 153–166 (2009).S7.Maciejowski, J. et al. Mps1 directs the assembly of Cdc20 inhibitory complexes during interphase and mitosis to control M phase timing and spindle checkpoint signaling. J. Cell Biol. 190, 89–100 (2010).S8.Siu, K. T., Rosner, M. R. & Minella, A. C. An integrated view of cyclin E function and regulation. Cell cycle 11, 57–64 (2012).S9.Hinds, P. W. et al. Regulation of retinoblastoma protein functions by ectopic expression of human cyclins. Cell 70, 993–1006 (1992).S10.Wood, D. J. & Endicott, J. A. Structural insights into the functional diversity of the CDK-cyclin family. Open Biol. 8, 180112 (2018).S11.Sherr, C. J. & Roberts, J. M. CDK inhibitors: positive and negative regulators of G1 phase progression. Genes Dev. 13, 1501–1512 (1999).S12.Kim, J. K. & Diehl, J. A. Nuclear cyclin D1: an oncogenic driver in human cancer. J. Cell. Physiol. 220, 292–296 (2009).S13.Quelle, D. E. et al. Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts. Genes Dev. 7, 1559–1571 (1993).S14.Oakenfull, E. A., Riou-Khamlichi, C. & Murray, A. H. Plant D-type cyclins and the control of G1 progression. Philos. Trans. R. Soc. London B Biol. Sci. 357, 749–760 (2002).S15.Shupp, A., Casimiro, M. C. & Pestell, R. G. Biological functions of CDK5 and potential CDK5 targeted clinical treatments. Oncotarget 8, 17373 (2017).S16.Griffin, S. V, Olivier, J. P., Pippin, J. W., Roberts, J. M. & Shankland, S. J. Cyclin I protects podocytes from apoptosis. J. Biol. Chem. 281, 28048–28057 (2006).S17.Brinkkoetter, P. T. et al. Cyclin I activates CDK5 and regulates expression of Bcl-2 and Bcl-XL in postmitotic mouse cells. J. Clin. Invest. 119, 3089–3101 (2009).S18.Guevara, T., Sancho, M., Pérez-Payá, E. & Orzáez, M. Role of CDK5/cyclin complexes in ischemia-induced death and survival of renal tubular cells. Cell cycle 13, 1617–1626 (2014).S19.Morales, F. & Giordano, A. Overview of CDK9 as a target in cancer research. Cell Cycle 15, 519–527 (2016).S20.Guen, V. J. et al. CDK10/cyclin M is a protein kinase that controls ETS2 degradation and is deficient in STAR syndrome. Proc. Natl. Acad. Sci. 110, 19525–19530 (2013).S21.Malumbres, M. Cyclin-dependent kinases. Genome Biol. 15, 122 (2014).S22.Clijsters, L. et al. Cyclin F controls cell-cycle transcriptional outputs by directing the degradation of the three activator E2Fs. Mol. Cell 74, 1264–1277 (2019).S23.Malumbres, M. & Barbacid, M. Mammalian cyclin-dependent kinases. Trends Biochem. Sci. 30, 630–641 (2005).S24.Keeling, P. J. et al. The Marine Microbial Eukaryote Transcriptome Sequencing Project (MMETSP): illuminating the functional diversity of eukaryotic life in the oceans through transcriptome sequencing. PLoS Biol. 12, e1001889 (2014).S25.Liu, H. et al. Symbiodinium genomes reveal adaptive evolution of functions related to coral–dinoflagellate symbiosis. Commun. Biol. 1, 1–11 (2018).S26.Parkinson, J. E. et al. Gene expression variation resolves species and individual strains among coral-associated dinoflagellates within the genus Symbiodinium. Genome Biol. Evol. 8, 665–680 (2016).S27.Shoguchi, E. et al. Draft assembly of the Symbiodinium minutum nuclear genome reveals dinoflagellate gene structure. Curr. Biol. 23, 1399–1408 (2013).S28.Aranda, M. et al. Genomes of coral dinoflagellate symbionts highlight evolutionary adaptations conducive to a symbiotic lifestyle. Sci. Rep. 6, 39734 (2016).S29.Bayer, T. et al. Symbiodinium transcriptomes: genome insights into the dinoflagellate symbionts of reef-building corals. PLoS One 7, e35269 (2012).S30.Ladner, J. T., Barshis, D. J. & Palumbi, S. R. Protein evolution in two co-occurring types of Symbiodinium: an exploration into the genetic basis of thermal tolerance in Symbiodinium clade D. BMC Evol. Biol. 12, 217 (2012).S31.González-Pech, R. A., Vargas, S., Francis, W. & W?rheide, G. Transcriptomic Resilience of a Coral Holobiont to Low pH. Front. Mar. Sci. 12, 403 (2017).S32.Levin, R. A. et al. Sex, scavengers, and chaperones: transcriptome secrets of divergent Symbiodinium thermal tolerances. Mol. Biol. Evol. 33, 2201–2215 (2016).S33.Xiang, T., Nelson, W., Rodriguez, J., Tolleter, D. & Grossman, A. R. Symbiodinium transcriptome and global responses of cells to immediate changes in light intensity when grown under autotrophic or mixotrophic conditions. Plant J. 82, 67–80 (2015).S34.Lin, S. et al. The Symbiodinium kawagutii genome illuminates dinoflagellate gene expression and coral symbiosis. Science (80-. ). 350, 691–694 (2015).S35.Shoguchi, E. et al. Two divergent Symbiodinium genomes reveal conservation of a gene cluster for sunscreen biosynthesis and recently lost genes. BMC Genomics 19, 458 (2018).S36.Jang, S. H., Jeong, H. J., Chon, J. K. & Lee, S. Y. De novo assembly and characterization of the transcriptome of the newly described dinoflagellate Ansanella granifera: Spotlight on flagellum-associated genes. Mar. Genomics 33, 47–55 (2017).S37.Blanc, G. et al. The Chlorella variabilis NC64A genome reveals adaptation to photosymbiosis, coevolution with viruses, and cryptic sex. Plant Cell 22, 2943–2955 (2010).S38.Arriola, M. B. et al. Genome sequences of Chlorella sorokiniana UTEX 1602 and Micractinium conductrix SAG 241.80: implications to maltose excretion by a green alga. Plant J. 93, 566–586 (2018).S39.Wakasugi, T. et al. Complete nucleotide sequence of the chloroplast genome from the green alga Chlorella vulgaris: the existence of genes possibly involved in chloroplast division. Proc. Natl. Acad. Sci. 94, 5967–5972 (1997).S40.Maor‐Landaw, K., van Oppen, M. J. H. & McFadden, G. I. Symbiotic lifestyle triggers drastic changes in the gene expression of the algal endosymbiont Breviolum minutum (Symbiodiniaceae). Ecol. Evol. 10, 451–466 (2020). ................
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