CURRICULUM VITAE - Research



CURRICULUM VITAE

Firstname : SHARSHAR Surname: Tarek

22 May 1964

Nationality : French

Married – One child

Personal address : Professional address :

10, Square Port-Royal Intensive care department

75013 Paris France Raymond Poincaré Hospital

(00 33 (0)1 45 87 93 05 104, Boulevard Raymond Poincaré

92380 Garches France

(00 33 (0)1 47 10 77 80

2013 Project of Master 2 in Reserarch “Neurosciences of Acute Brain Injury” Submitted to Ministère de l’Enseignement Supérieur et de la Recherche

2013 Co-Organiser of Versailles International Neurocritical Care Symposium on “Science of Consciousness in Acute Neurological Disorders”. Palais des congrès de Versailles – June 20 et 21st 2013

2012 Co-Organiser of Versailles International Neurocritical Care Symposium on “Brain Injury, Brain repair, From Bench to Bedside”. Palais des congrès de Versailles – June 21et 29Juin

2011 Co-Organiser of Versailles International Neurocritical Care Symposium on Delirium in ICU. Palais des congrès de Versailles – June 28th et 29th 2

2009-2011 Coordinator of university diploma in Neurointensive Care Medicine - University of Versailles Saint-Quentin en Yvelines

2009 Member of the Round Table in ICU-acquired Paresis (ISICEM, Brussels)

2008 Coordinator of the regional training in Neurointensive Care Medicine for diploma in Intensive Care Medicine

2007 Professor in Intensive Care Medicine – University of University of Versailles Saint-Quentin en Yvelines

2006 Qualification to supervise research ( Habilitation à diriger des recherches). University of Versailles Saint-Quentin en Yvelines.

2003 – 2005 Consultant in intensive care unit in the teaching hospital Raymond Poincaré (Professor D Annane) – Garches, France.

2001 – 2003 PhD in Respiratory Muscle Laboratory in Royal Brompton Hospital (Dr M. Polkey, Imperial College).

2000 – 2001: Consultant in Lung Function Laboratory in the teaching hospital Raymond Poincaré (Professor F. Lofaso) - Garches, France.

1996-2000 Medical Registrar  in intensive care unit in the teaching hospital Raymond Poincaré (Professor Ph. Gajdos) - Garches, France.

1998: Diploma in critical care medicine

1996 : Higher Degree in Molecular and cellular Pharmacology

Supervisor : Professor Ph. Ascher and Professor M. Kazatchkine

Selective Impairment of serum antibody repertoires toward muscle and thymus in patients with seropositive and seronegative myasthenia gravis.

1996 : Medical thesis

Supervisor: Professor J.L. Mas

Incidence and causes of stroke during pregnancy and puerperium. A study in public hospitals of Ile de France. Stroke.

1996 : Diploma in Neurology

Supervisor: Professor Y Agid and Professor O Lyon-Caen

1995 : Diploma in Statistics applied to medical research

1990: Concours de l’internat d’Ile de France.

CURRENT RESEARCH ACTIVITY

1 – Neuropathological research on Blood-Brain Barrier dysfunction, microglial activation and microglial-astrocytes interaction in human and experimental sepsis. Collaboration with

Pr Fabrice Chrétien, Institut Pasteur, Paris, France;

Pr Greet van den Berghe, University of Leuven, Belgium

2 – Investigation of septic shock related osmoregulation dysfunction. Collaboration with

Pr Charles Bourques, Mc Gill University

3 – Clinical and Neurophysiological of brainstem dysfunction in critically ill patients. Collaboration with

Pr Jean Mantz University Denis Diderot, Hôpital Beaujon

4 – Pathophysiology and outcomes of critical illness neuromyopathy Collaboration with

Pr Fabrice Chrétien, Institut Pasteur, Paris, France;

5 – Multicentre randomized clinical trials on steroids tapering in patients with myasthenia gravis (current inclusion)

6 – Multicentre randomized trial on impact of long term follow-up of patients discharged from ICU (Grant accepted in 2010)

7 – Multicentre randomized trial on intravenous valproate as adjunctive anti-epileptic drug in status epilepticus (Grant accepted in 2010)

8 – Bicenter study on Impact of exercise on quality of life of patients with Myasthenia Gravis (Grant accepted in 2012)

9 – Clinical and Neurophysiological assessment of Brainstem dysfunction in Critically ill Patients (Grant accepted in 2012)

SUPERVISING OF MASTER 2 AND PHD STUDENTS

From 2007 to 2013: 7 Master 2 students

From 2007 to 2013: 3 PhD students

PUBLICATIONS

Indice H: 36 (google scholar)

Citations: 5683 (google scholar)

ORIGINAL ARTICLES (in peer-reviewed journals ; n=70)

1. Azabou E, Fischer C, Mauguiere F, Vaugier I, Annane D, Sharshar T, Lofaso F. Prospective Cohort Study Evaluating the Prognostic Value of Simple EEG Parameters in Postanoxic Coma. Clin EEG Neurosci. 2015 accepted.

2. Azabou E, Magalhaes E, Braconnier A, Yahiaoui L, Moneger G, Heming N, Annane D, Mantz J, Chrétien F, Durand MC, Lofaso F, Porcher R, Sharshar T; Groupe d’Explorations Neurologiques en Réanimation (GENER). Early Standard Electroencephalogram Abnormalities Predict Mortality in Septic Intensive Care Unit Patients. Plosone 2015; 10(10):e0139969

3. Stare J, Siami S, Trudel E, Prager-Khoutorsky M, Sharshar T, Bourque CW. Effects of Peritoneal Sepsis on Rat Central Osmoregulatory Neurons Mediating Thirst and Vasopressin Release. J Neurosci. 2015 ; 35(35):12188-97. 

4. Tsonis AI, Zisimopoulou P, Lazaridis K, Tzartos J, Matsigkou E, Zouvelou V, Mantegazza R, Antozzi C, Andreetta F, Evoli A, Deymeer F, Saruhan-Direskeneli G, Durmus H, Brenner T, Vaknin A, Berrih-Aknin S, Behin A, Sharshar T, De Baets M, Losen M, Martinez-Martinez P, Kleopa KA, Zamba-Papanicolaou E, Kyriakides T, Kostera-Pruszczyk A, Szczudlik P, Szyluk B, Lavrnic D, Basta I, Peric S, Tallaksen C, Maniaol A, Casasnovas Pons C, Pitha J, Jakubíkova M, Hanisch F, Tzartos SJ. MuSK autoantibodies in myasthenia gravis detected by cell based assay--A multinational study. J Neuroimmunol. 2015 Jul 15;284:10-7.

5. Sonneville R, Derese I, Marques MB, Langouche L, Derde S, Chatre L, Chrétien F, Annane D,Sharshar T, Van den Berghe G, Vanhorebeek I. Neuropathological Correlates of Hyperglycemia During Prolonged Polymicrobial Sepsis in Mice. Shock. 2015 ; 44:245-51.

6. Pène F, Ait-Oufella H, Taccone FS, Monneret G, Sharshar T, Tamion F, Mira JP; Commission de Recherche Translationnelle de la Société de Réanimation de Langue Française (SRLF). Insights and limits of translational research in critical care medicine. Ann Intensive Care. 2015 30;5:8. 

7. Lai A, Outin HD, Jabot J, Mégarbane B, Gaudry S, Coudroy R, Louis G, Schneider F, Barbarot N, Roch A, Lerolle N, Luis D, Fourrier F, Renault A, Argaud L, Sharshar T, Gibot S, Bollaert PE. Functional outcome of prolonged refractory status epilepticus. Crit Care 2015 30; 19:199.

8. SUTTER R, CHALELA JA, LEIGH R, KAPLAN PW, YENOKYAN G, SHARSHAR T, STEVENS RD. Significance of Parenchymal Brain Damage in Patients with Critical Illness. Neurocrit Care 2015

9. SHARSHAR T, CITERIO G, ANDREWS PJ, CHIEREGATO A, LATRONICO N, MENON DK, PUYBASSET L, SANDRONI C, STEVENS RD. Neurological examination of critically ill patients: a pragmatic approach. Report of an ESICM expert panel. Intensive Care Med. 2014Apr;40:484-95

10. SIAMI S, POLITO A, PORCHER R, HISSEM T, BLANCHARD A, BOUCLY C, CARLIER R, ANNANE D, HAYMANN JP, SHARSHAR T. Thirst perception and osmoregulation of vasopressin secretion are altered during recovery from septic shock. PLoS One 2013

11. POLITO A, EISCHWALD F, MAHO AL, POLITO A, AZABOU E, ANNANE D, CHRÉTIEN F, STEVENS RD, CARLIER R, SHARSHAR T. Pattern of Brain Injury in the Acute Setting of Human Septic Shock. Crit Care 2013

12. AZABOU E, ROCHE N, SHARSHAR T, BUSSEL B, LOFASO F, PETITJEAN M.Transcranial direct-current stimulation reduced the excitability of diaphragmatic corticospinal pathways whatever the polarity used. Respir Physiol Neurobiol. 2013 189 : 183-7. 

13. Nardi O, Polito A, Aboab J, Colin G, Maxime V, Clair B, Friedman D, Orlikowski D,Sharshar T, Annane D. StO₂ guided early resuscitation in subjects with severe sepsis or septic shock: a pilot randomised trial. J Clin Monit Comput. 2013 27:215-21.

14. SHARSHAR T, POLITO A, PORCHER R, MERHBENE T, BLANC M, ANTONA M, DURAND MC, FRIEDMAN D, ORLIKOWSKI D, ANNANE D, MARCADET MH. Relevance of anxiety in clinical practice of Guillain-Barre syndrome: a cohort study. BMJ Open. 2012 pii: e000893. doi: 10.1136/bmjopen-2012-000893.

15. HOPKINSON NS, SHARSHAR T, DAYER MJ, LOFASO F, MOXHAM J, POLKEY MI. The effect of acute non-invasive ventilation on corticospinal pathways to the respiratory muscles in chronic obstructive pulmonary disease. Respir Physiol Neurobiol. 2012 183(1):41-7.

16. SONNEVILLE R, DEN HERTOG HM, GÜIZA F, GUNST J, DERESE I, WOUTERS PJ, BROULAND JP, POLITO A, GRAY F, CHRÉTIEN F, CHARLIER P, ANNANE D, SHARSHAR T, VAN DEN BERGHE G, VANHOREBEEK I. Impact of hyperglycemia on neuropathological alterations during critical illness. J Clin Endocrinol Metab. 2012 97(6):2113-23.

17. POLITO A, SONNEVILLE R, GUIDOUX C, BARRETT L, VILTART O, MATTOT V, SIAMI S, LORIN DE LA GRANDMAISON G, CHRETIEN F, SINGER M, GRAY F, ANNANE D, BROULAND JP, SHARSHAR T.Changes in CRH and ACTH Synthesis during Experimental and Human Septic Shock. PLoS One. 2011;6(11):e25905

18. COLIN G, NARDI O, POLITO A, ABOAB J, MAXIME V, CLAIR B, FRIEDMAN D, ORLIKOWSKI D, SHARSHAR T, ANNANE D. Masseter tissue oxygen saturation predicts normal central venous oxygen saturation during early goal-directed therapy and predicts mortality in patients with severe sepsis. Crit Care Med. 2011

19. A Polito, JP Brouland, R Porcher, R Sonneville, S Siami, RD Stevens, Guidoux C, V Maxime, G Lorin de la Grandmaison, F Chretien, F Gray, D Annane, T Sharshar. Hyperglycaemia and apoptosis of microglial cells in human septic shock. Crit Care. 2011 15(3):R131.

20. M Schmidt, A. Demoule, A. Polito, R. PorcheR, J. Aboab, Siami S, C. Morelot-Panzini, T. Similowski, T. Sharshar. Dyspnea in mechanically ventilated critically ill patients. Crit Care Med. 2011

21. T SHARSHAR, R PORCHER, S SIAMI, B ROHAUT, J BAILLY-SALIN, NS HOPKINSON, B ClAIR, C GUIDOUX; E IACOBONE, R SONNEVILLE, A POLITO, J ABOAB, S GAUDRY, O MORLA, G AMOUYAL, J AZUAR, J ALLARY, A VEILLARD-BARON, M WOLF, A. CARIOU, D ANNANE.  Brainstem responses can predict death and delirium in sedated paztients in intensive care unit. Crit Care Med 2011 39 :1960-7.

22. D Orlikowski, R Porcher, V Sivadon-Tardy, JC Quincampoix, Raphaël JC, MC Durand, T Sharshar, J Roussi, C Caudie, D Annane, F Rozenberg, M Leruez-Ville, JL Gaillard, E Gault. Guillain-Barré syndrome following primary cytomegalovirus infection: a prospective cohort study. Clin Infect Dis. 2011 52: 837-44

23. Sharshar T, Bastuji-Garin S, Polito A, De Jonghe B, Stevens RD, Maxime V, Rodriguez P, Cerf C, Outin H, Touraine P, Laborde K; the Groupe de Réflexion et d'Etude des Neuromyopathies En Réanimation. Hormonal status in protracted critical illness and in-hospital mortality. Crit Care. 2011 15: R47.

24. V Martinez V, D Fletcher D, F Martin F, D Orlikowski D, T Sharshar, M Chauvin, D Bouhassira, N Attal. Small fibre impairment predicts neuropathic pain in Guillain-Barré syndrome. Pain 2010 151:53-60

25. S Siami, J Bailly-Salin, A Polito, R Porcher, A Blanchard , JP Haymann, K Laborde, V Maxime, C Boucly, R Carlier, D Annane, T Sharshar. Osmoregulation of vasopressin secretion is altered in the postacute phase of septic shock. Crit Care Med. 2010 38: 1962-9

26. Polito A, G Lorin de la Grandmaison, A Mansart , E Louiset, H Lefebvre, T Sharshar , D Annane. Human and experimental septic shock are characterized by depletion of lipid droplets in the adrenals. Intensive Care Med. 2010 36: 1852-8.

27. T. Sharshar, Bastuji-Garin S, De Jonghe B, Stevens RD, Polito A, Maxime V, Rodriguez P, Cerf C, Outin H, Touraine P, Laborde K. Hormonal status and ICU-acquired paresis in critically ill patients. Intensive Care Med. 2010 36: 1318-26

28. V. Sivadon-Tardy, Orlikowski D, Porcher R, Ronco E, Caudie C, Roussi J, Fauchère JL, Mégraud F, Tabor H, T. Sharshar, Annane D, Raphaël JC, Gaillard JL. Detection of Campylobacter jejuni by culture and real-time PCR in a French cohort of patients with Guillain-Barre syndrome. J Clin Microbiol. 2010 48: 2278-81

29. R Sonneville, C Guidoux, L Barrett, O Viltart, V Mattot, A Polito, S Siami, GL de la Grandmaison, A Blanchard, M Singer, D Annane, F Gray, JP BROULAND, T Sharshar. Vasopressin Synthesis by the Magnocellular Neurons is Different in the Supraoptic Nucleus and in the Paraventricular Nucleus in Human and Experimental Septic Shock. Brain Pathology 2010 20: 613-22

30. T. SHARSHAR, S. Bastuji-Garin, RD. Stevens, MC. Durand, I. Malissin, P. Rodriguez, C. Cerf, H. Outin, B. De Jonghe for the Groupe de Réflexion et d’Etude des Neuromyopathies En Réanimation (GRENER). Presence and severity of ICU-Acquired paresis at the time of awakening are associated with increased ICU and hospital mortality. Crit Care Med. 2009; 37: 3047-3053

31. J. STRAUSS, J. ABOAB, M. ROTTMAN, R. PORCHER, L. IKKA, A. POLITO, M-C DURAND, D. ORLIKOWSKI, C. DEVAUX, F. LOFASO, D. ANNANE, J-L. GAILLARD, T. SHARSHAR. Plasma cortisol levels in Guillain-Barré syndrome. Crit Care Med. 2009; 37: 2436-2440

32. V. Sivadon-Tardy, D. Orlikowski, R. Porcher, T. Sharshar, MC Durand, V Enouf, F. Rozenberg, C. Caudie, D Annane, S van der Werf, P Lebon, JC Raphaël, JL Gaillard, E Gault. Guillain-Barré syndrome and influenza virus infection. Clin Infect Dis. 2009 ; 48: 48-56

33. D. OLIKOWSKI, N. TERZI, M. BLUMEN, T. SHARSHAR, J-C. RAPHAEL, D. ANNANE, F. LOFASO. Tongue weakness is associated with respiratory failure in patients with severe Guillain-Barré syndrome. Acta Neurol Scand. 2008; 119: 364-370

34. J. Aboab, A. Polito, D. Orlikowski, T. Sharshar, M. Castel, D. Annane. Hydrocortisone effects on cardiovascular variability in septic shock: a spectral analysis approach. Crit Care Med. 2008; 36: 1481-6.

35. B. De Jonghe, S. Bastuji-Garin, M.C. Durand, I. Malissin, P. Rodrigues, C. Cerf, H. Outin, T. Sharshar. Respiratory weakness is associated with limb weakness and delayed weaning in critical illness. Crit Care Med 2007; 35: 2007-2005

36. T. Sharshar, R. Carlier, F. Bernard, C. Guidoux, J-P. Brouland, O. Nardi, G. L. de la Grandmaison, J. Aboab, F. Gray, D. Menon, D. Annane. Brain lesions in septic shock: a magnetic resonance imaging study. Intensive Care Med. 2007; 33: 798-806.

37. M.C. Durand, R. Porcher, D. Orlikowski, J. Aboab, C. Devaux, B. Clair, D. Annane, J-L. Gaillard, F. Lofaso, J-C. Raphael, T. Sharshar. Clinical and electrophysiological predictors of respiratory failure in Guillain-Barré syndrome: a prospective study. Lancet Neurol. 2006; 5:1021-1028.

38. D Orlikowski, T Sharshar, R Porcher, D Annane, JC Raphael, B Clair. Prognosis and risk factors of early onset pneumonia in ventilated patients with Guillain-Barre syndrome. Intensive Care Med. 2006; 32: 1962-1969

39. MJ Dayer, S Jonville, M Chatwin, EB Swallow, R Porcher, T Sharshar, ET Ross, NS Hopkinson, J Moxham, MI Polkey. Exercise-induced depression of the diaphragm motor evoked potential is not affected by non-invasive ventilation. Respir Physiol Neurobiol. 2006 (sous presse)

40. V Sivadon-Tardy, D Orlikowski, F Rozenberg, C Caudie, T Sharshar, P Lebon, D Annane, JC Raphael, R Porcher, JL Gaillard. Guillain-Barre syndrome, greater Paris area. Emerg Infect Dis. 2006;12: 990-993.

41. MC DURAND, H. PRIGENT, V. SIVADON-TARDY, D. ORLIKOWSKI, C. CAUDIE, C. DEVAUX, B. CLAIR, J.L. GAILLARD, F. LOFASO, J.C. RAPHAEL, T. SHARSHAR. Significance of phrenic nerve electrophysiological abnormalities in Guillain-Barre syndrome. Neurology. 2005; 65: 1646-1649.

42. M.J. DAYER, N.S. HOPKINSON, E.T. ROSS, S. JONVILLE, T. SHARSHAR, M. KEARNEY, J. MOXHAM, M.I. POLKEY. Does symptom-limited cycle exercise cause low frequency diaphragm fatigue in patients with heart failure? Eur J Heart Fail. 2005

43. T. SHARSHAR, N. HOPKINSON, E. ROSS, S. JONVILLE, M. DAYER, A. NICKOL, F. LOFASO, J. MOXHAM, M. POLKEY. Motor control of the costal and crural diaphragm--insights from transcranial magnetic stimulation in man. Resp Physiol and Neurobiol. 2005; 146: 5-19.

44. T. SHARSHAR, N. HOPKINSON, S. JONVILLE, M. DAYER, E. SWALLOW, J. MOXHAM, F. LOFASO, M. POLKEY. Demonstration of a second rapidly cortico-diaphragmatic pathway in humans. J Physiol (Lond). 2004, 560: 897-908.

45. N. HOPKINSON, T. SHARSHAR, E. ROSS, A. Nickol, M. DAYER, F. LOFASO, J. MOXHAM, M. POLKEY. Impaired effect of voluntary facilitation on the diaphragmatic response to transcranial magnetic stimulation in patients with COPD. Resp Physiol and Neurobiol. 2004; 141: 1-12.

46. T. SHARSHAR, N.S. HOPKINSON, E.T. ROSS, A.H. Nickol, Y. LUO, M. DAYER, N. HART, J. MOXHAM, F. LOFASO, M. POLKEY. Effect of isocapnic mechanical ventilation on costal and crural diaphragmatic response to transcranial magnetic stimulation. J Applied Physiol. 2004; 97: 3-12.

47. B. De Jonghe, S. Bastuji-Garin, T. Sharshar, H.D. Outin, L. Brochard for the GRENER (Groupe de Reflexion et d’Etude des Neuromyopathies En Reanimation). Relationship between ICU Acquired Paralysis and duration of mechanical ventilation in awakening ICU patients. Int Care Med. 30: 1117-1121.

48. T. Sharshar, D. Annane, G. Lorin de la Grandmaison, A. Dorandeu, N. HOPKINSON, F. GRAY. The neuropathology of septic shock: a prospective case-control study. Brain Pathology, 2004, 14 : 21-33.

49. T. Sharshar, F. Gray, G. Lorin de la Grandmaison, A. Dorandeu, D. OrLIKOWSKI, J.C. RAPHAEL, P. Gajdos, N. HOPKINSON, D. Annane. Apoptosis and inducible nitric oxide expression in autonomic centres controlling the cardiovascular system in human septic shock. Lancet 2003; 362: 1799-1805.

50. N. Hart, M. Polkey, T. Sharshar, L. Falaize, B. Fauroux, J.C. Raphaël, F. Lofaso. Limitations of sniff nasal pressure in patients with severe respiratory muscle weakness. J Neurol Neurosurg Psychiatry 2003; 74: 1685-1687.

51. T. Sharshar, E. Ross, N. Hopkinson, M. Dayer, A. Nickol, T. Similowski, F. Lofaso, J. Moxham, M. Polkey. Effect of voluntary facilitation on the diaphragmatic response to transcranial magnetic stimulation. Journal Applied Physiology 2003; 95: 26-34.

52. T Sharshar, G Desmarais, M Polkey, B Louis, G Macadou, JC Raphaël, D Isabey, F Lofaso. Transdiaphragmatic pressure control of airway pressure support in healthy subjects. Am J Resp Crit Care Med 2003; 168: 760-769.

53. T Sharshar, A Blanchard, M Paillard, JC Raphaël, P Gajdos et D Annane. Circulating vasopressin levels in septic shock. Crit Care Med 2003; 31: 1752-1758.

54. J. Gonzalez, T. Sharshar, K. Chadda, N. Hart, F. Lofaso, J.C. Raphaël. Air Leaks during Mechanical Ventilation as a Cause of Hypercapnia in Neuromuscular Disorders. Intensive Care Med 2003; 29: 596-602.

55. T Sharshar, S Chevret, F Bourdain, JC Raphaël for the French Cooperative Group on Plasma Exchange in Guillain-Barré Syndrome. Early Predictors of Mechanical Ventilation in Guillain-Barré Syndrome. Crit Care Med 2002; 31: 278-283.

56. M.C. Durand, F. Lofaso, J.P Lefaucheur, S. Chevret, J.C. Raphaël, T. Sharshar. Electrophysiology to Predict Mechanical Ventilation in Guillain-Barré Syndrome. Eur J Neurol. 2003; 10 : 39-44.

57. D. Orlikowski, B. Chazaud, A. PLONQUET, F. Poron, T. Sharshar, J.C. Raphaël, R.K. Gheradi, A. Créange. Monocytes chemoattractant protein1 and chemokine receptor CCR2 production in Guillain-Barré (GBS) and experimental autoimmune neuritis. J Neuroimmunol 2003; 134: 118-127.

58. B. De Jonghe, T. Sharshar, J.P. Lefaucheur, J. Auhtier, I. Durand-Zaleski, M. Boussarsar, C. Cerf, E. Renaud, S. Bastuji-Garin for the GRENER (Groupe de Reflexion et d’Etude des Neuromyopathies En Reanimation). ICU Acquired Paralysis: A prospective multicentric study. JAMA 2002; 288: 2858-2867.

59. T Sharshar, J-P Lefaucheur, M-C Durand, F Lofaso, J-C Raphaël, R.K. Gherardi, A. Créange. Circulating Matrix Metalloproteinase MMP-9 Correlates with Electrophysiological Abnormalities in Guillain-Barré Syndrome. Neurology 2002; 59: 1649-1651.

60. T Sharshar, F Gray, A Dorandeu, F Bourdain, F Brion, T Ereau, JC Raphaël, P Gajdos, D Annane. Multifocal necrotizing leukoencephalopathy: a new mechanism of brain damages in septic shock involving pro-inflammatory cytokines. Crit Care Med 2002; 30: 2371-2375.

61. T Sharshar, R Carlier, A Blanchard, A Feydy, F Gray, M Paillard, JC Raphaël, P Gajdos, D Annane. Depletion of neurohypophyseal content of vasopressin in septic shock. Crit Care Med. 2002; 30: 497-500.

62. A Créange, B Chazaud, A Plonquet, T Sharshar, F Poron, C Sonnet, JC Raphaël, RK Gherardi. IFN-beta decreases adhesion and transmigration capacities of lymphocytes in Guillain-Barré Syndrome. Neurology. 2001; 57: 1704-1706.

63. D Annane, T Sharshar, M Korach, I Jarrin, J-P Fouillot, J-C Raphaël, P Gajdos. Assessment of sympathovagal balance in critically ill adults: an early diagnostic test for sepsis. Crit Care Med. 2001; 29: 1380-1385.

64. A Créange, B Chazaud, T Sharshar, Planchenault, JC Raphaël, R Gherardi. Inhibition of the adhesion step of the leukodiapedesis: a critical event in the recovery of Guillain-Barré syndrome associated with accumulation of proteotically active lymphocytes in blood. J Neuroimmunol. 2001, 114: 188-196.

65. T Sharshar, S Chevret, M Mazighi, P Chillet, Cl Bereotta, M Houfani, G Huberfeld, P Gajdos. Validity and reliability of two muscular scores, commonly used as endpoints in treatment of myasthenia gravis. Journal of Neurology. 2000; 247: 286-290.

66. A Créange, T Sharshar, Planchenault, JC Raphaël, R Gherardi. Matrix metalloproteinase-9 is increased and correlates with severity in GBS. Neurology. 1999; 53: 1683-1691.

67. D. Annane, F. Trabold, T. Sharshar, I. Jarrin, A.S. Blanc, J.C. Raphaël, P. Gajdos. Inappropriate sympathetic activation at onset of septic shock. A spectral analysis approach. Am J Respir Crit Care Med. 1999; 160: 458-465.

68. B. de Jonghe, D. Cook, T. Sharshar, J.P. Lefaucheur, J. Carlet, H. Outin. Acquired neuromuscular disorders in critically ill patients. A systematic review. Intensive Car Med. 1998; 24: 1242-1250.

69. T. Sharshar, S. Lacroix-Desmaze, L. Mouthon, S. Kaveri, P. Gajdos, M.D. kazatchkine. Selective Impairment of serum antibody repertoires toward muscle and thymus in patients with seropositive and seronegative myasthenia gravis. Eur J Immunol. 1998; 28: 2344-2354.

70. T. Sharshar, C. Lamy, J.L. Mas. Incidence and causes of stroke during pregnancy and puerperium. A study in public hospitals of Ile de France. Stroke. 1995; 26: 930-936.

Case Report

1. S Deniz, C Oppenheim, S Lehéricy, T Sharshar, T Laham, B Marro, M Sahel, Y Samson, D Dormont, C Marsault. Diffusion-weighted magnetic resonance imaging in a case of methanol intoxication. Neurotoxicity. 2000; 21:405-408.

2. T Sharshar, I Auriant, A Dorandeu, M Saghatchian, L Bélec, B Benyahia, JC Raphaël, P Gajdos, J-Y Delattre, F Gray. Association of herpes simplex virus encephalitis and paraneoplastic encephalitis - A clinico-pathological study. Ann Pathol. 2000; 20: 249-252.

REVIEWS (in peer-reviewed journals; n=25)

SONNEVILLE R, VANHOREBEEK I, DEN HERTOG HM, CHRÉTIEN F, ANNANE D,SHARSHAR T, VAN DEN BERGHE G. Critical illness-induced dysglycemia and the brain. Intensive Care Med. 2015; 41192-202

ANNANE D, SHARSHAR T. Cognitive decline after sepsis. Lancet Respir Med. 2015 3:61-69

ADAM N, KANDELMAN S, MANTZ J, CHRÉTIEN F, SHARSHAR T.Sepsis-induced brain dysfunction. Expert Rev Anti Infect Ther. 2013 11(2):211-21.

BOZZA FA, D'AVILA JC, RITTER C, SONNEVILLE R, SHARSHAR T, DAL-PIZZOL F. Bioenergetics, mitochondrial dysfunction, and oxidative stress in the pathophysiology of septic encephalopathy. Shock. 2013 May;39 Suppl 1:10-6. 

SONNEVILLE R, VERDONK F, RAUTURIER C, KLEIN IF, WOLFF M, ANNANE D, CHRETIEN F,SHARSHAR T. Understanding brain dysfunction in sepsis. Ann Intensive Care. 2013 May 29;3(1):15. doi: 10.1186/2110-5820-3-15.

N STOCCHETTI, PL ROUX, P VESPA, M ODDO, G CITERIO G, PJ ANDREWS,

RD STEVENS, T SHARSHAR, FS TACCONE, JL VINCENT. Clinical review: Neuromonitoring - an update. Crit Care. 201317:201.

1. E Iacobone, J Bailly-Salin, A Polito, D Friedman, RD Stevens, T Sharshar Sepsis-associated encephalopathy and its differential diagnosis. Crit Care Med. 2009

2. B de Jonghe, JC Lacherade, T Sharshar, H Outin. Intensive care unit-acquired weakness: risk factors and prevention. Crit Care Med. 2009

3. RD Stevens, SA Marshall, DR Cornblath, A Hoke, DM Needham,B de Jonghe, NA Ali, T Sharshar. A framework for diagnosing and classifying intensive care unit-acquired weakness. Crit Care Med. 2009

4. N Akrout, T Sharshar, D Annane Mechanisms of brain signaling during sepsis. Curr Neuropharmacol. 2009

5. T. SHARSHAR, D. ANNANE. Endocrine effects of vasopressin in critically ill patients. Best Pract Res Clin Anaesthesiol 2008; 22: 265-73.

6. IK. HART, T. SHARSHAR, S. SATHASIVAM. Immunosuppressant drugs for myasthenia gravis. J Neurol Neurosurg Psychiatry. 2009; 80:5-6

7. B. De Jonghe, JC. Lacherade, MC. Durand, T. Sharshar. Critical illness neuromuscular syndromes. Neurol Clin. 2008 26: 507-20

8. S. SiaMI, D. ANNANE, T. SHARSHAR. The encephalopathy in sepsis. Crit Care Clin 2008; 24: 55-69

9. B. De Jonghe, J.C. Lacherade, M.C. Durand, T. Sharshar. Critical illness neuromuscular syndromes. Crit Care Clin 2007; 23: 55-69.

10. I.K. Hart, S. Sathasivam, T. Sharshar. Immunosuppressive agents for myasthenia gravis. Cochrane Database Syst Rev. 2007; 4:CD005224.

11. M. Ebersoldt, T. Sharshar, D. Annane. Sepsis-associated delirium. Intensive Care Med. 200733: 941-50.

12. J. Aboab, O. Nardi, D. Lipiner, T. Sharshar, D. Annane. Emerging drugs for the treatment of sepsis. Expert Opin Emerg Drugs. 2006; 11: 7-22.

13. T. Sharshar, N. Hopkinson, D. Orlikowski, D. Annane. Science review: The brain in sepsis--culprit and victim. Crit Care 2005; 9: 37-44.

D. ORLIKOWSKI, H. PRIGENT, T. SHARSHAR, J.C. RAPHAEL. Respiratory dysfunction in Guillain-Barre Syndrome. Neurocrit Care. 2004;1(4):415-22.

14. T. SHARSHAR, N. HOPKINSON, D. ORLIKOWSKI, D. ANNANE. Science review: The brain in sepsis--culprit and victim. Crit Care. 2005 Feb;9(1):37-44.

15. D. ORLIKOWSKI, T. SHARSHAR, D. ANNANE. Brain in sepsis. Advance in sepsis. (in Press).

16. JC Raphaël, S Chevret, I Auriant, T Sharshar, J Bouget, F Bolgert. Treatment of the adult Guillain-Barre syndrome: indications for plasma exchange. Transfu Sci. 1999, 20: 53-6

17. T Sharshar, S Kaveri, M Kazatchkine. Mechanisms of action of intravenous immunoglobulin (IVIg) in autoimmune and neuromuscular diseases. Electroencephalogr Clin Neurophysiol Suppl. 19

CONGRES

Nationaux: SRLF (2003_2015)

Internationaux: ESICM (2008-2015) et ISICEM (2007-2013, 2015)

Congrès de la société scandinave de réanimation (2014), de la British Thoracic Society (2013, 2014), de la société allemande de Neuroréanimation (2014 et 2015).

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