Ars.els-cdn.com



Transcatheter aortic valve replacement in patients with multivalvular heart disease Supplemental MaterialFaisal Khan, MBBS1*; Taishi Okuno, MD1*; Daniel Malebranche, MD1; Jonas Lanz, MD1; Fabien Praz, MD1; Stefan Stortecky, MD1; Stephan Windecker, MD1; Thomas Pilgrim, MD1*the first two authors contributed equally to this articleDepartment of Cardiology, Inselspital, Bern University Hospital, University of Bern, SwitzerlandBrief title: Multivalvular disease Funding: NoneDisclosures: Dr. Windecker reports having received research grants to the institution from Abbott, Biotronik, Boston Scientific, Edwards Lifesciences, Medtronic, Medicines Company. Dr. Pilgrim reports having received research grants to the institution from Edwards Lifesciences, Symetis, and Biotronik. All other authors have no relationships relevant to the contents of this article to disclose.Corresponding Author: Thomas Pilgrim, MDDepartment of CardiologyInselspital, Bern University HospitalUniversity of BernCH-3010 BernSwitzerlandPhone: 0041 31 632 21 11Fax: 0041 31 632 47 70Mail: thomas.pilgrim@insel.chSuppl. Table 1.Mitral valve DevicesTranscatheter Mitral Valve RepairDevice/ManufacturerMechanism of actionAccessStudyApprovalMitraClipAbbott Vascular, Santa Clara, CA, USACoaptation enhancementTrans-septalPrimary MR: EVEREST II PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5GZWxkbWFuPC9BdXRob3I+PFllYXI+MjAxMTwvWWVhcj48

UmVjTnVtPjQxODwvUmVjTnVtPjxEaXNwbGF5VGV4dD4oMSk8L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+

PHJlYy1udW1iZXI+NDE4PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBk

Yi1pZD0iOXdlZXI1eDBxZHN0MDVldGYyMTV0eHI1emFzdnRydHRzMHo1IiB0aW1lc3RhbXA9IjE1

ODA0NjU3MjAiPjQxODwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFs

IEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+RmVs

ZG1hbiwgVC48L2F1dGhvcj48YXV0aG9yPkZvc3RlciwgRS48L2F1dGhvcj48YXV0aG9yPkdsb3dl

ciwgRC4gRC48L2F1dGhvcj48YXV0aG9yPkthciwgUy48L2F1dGhvcj48YXV0aG9yPlJpbmFsZGks

IE0uIEouPC9hdXRob3I+PGF1dGhvcj5GYWlsLCBQLiBTLjwvYXV0aG9yPjxhdXRob3I+U21hbGxp

bmcsIFIuIFcuPC9hdXRob3I+PGF1dGhvcj5TaWVnZWwsIFIuPC9hdXRob3I+PGF1dGhvcj5Sb3Nl

LCBHLiBBLjwvYXV0aG9yPjxhdXRob3I+RW5nZXJvbiwgRS48L2F1dGhvcj48YXV0aG9yPkxvZ2hp

biwgQy48L2F1dGhvcj48YXV0aG9yPlRyZW50bywgQS48L2F1dGhvcj48YXV0aG9yPlNraXBwZXIs

IEUuIFIuPC9hdXRob3I+PGF1dGhvcj5GdWRnZSwgVC48L2F1dGhvcj48YXV0aG9yPkxldHNvdSwg

Ry4gVi48L2F1dGhvcj48YXV0aG9yPk1hc3Nhcm8sIEouIE0uPC9hdXRob3I+PGF1dGhvcj5NYXVy

aSwgTC48L2F1dGhvcj48YXV0aG9yPkV2ZXJlc3QgSWkgSW52ZXN0aWdhdG9yczwvYXV0aG9yPjwv

YXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkV2YW5zdG9uIEhvc3BpdGFsLCBO

b3J0aFNob3JlIFVuaXZlcnNpdHkgSGVhbHRoIFN5c3RlbSwgRXZhbnN0b24sIElMIDYwMjAxLCBV

U0EuIHRmZWxkbWFuQG5vcnRoc2hvcmUub3JnPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+

UGVyY3V0YW5lb3VzIHJlcGFpciBvciBzdXJnZXJ5IGZvciBtaXRyYWwgcmVndXJnaXRhdGlvbjwv

dGl0bGU+PHNlY29uZGFyeS10aXRsZT5OIEVuZ2wgSiBNZWQ8L3NlY29uZGFyeS10aXRsZT48L3Rp

dGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5OIEVuZ2wgSiBNZWQ8L2Z1bGwtdGl0bGU+PC9w

ZXJpb2RpY2FsPjxwYWdlcz4xMzk1LTQwNjwvcGFnZXM+PHZvbHVtZT4zNjQ8L3ZvbHVtZT48bnVt

YmVyPjE1PC9udW1iZXI+PGVkaXRpb24+MjAxMS8wNC8wNjwvZWRpdGlvbj48a2V5d29yZHM+PGtl

eXdvcmQ+QWdlZDwva2V5d29yZD48a2V5d29yZD5GZW1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+SGVh

cnQgRmFpbHVyZS9lcGlkZW1pb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+SGVhcnQgVmFsdmUgUHJv

c3RoZXNpcyBJbXBsYW50YXRpb24vKm1ldGhvZHM8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9r

ZXl3b3JkPjxrZXl3b3JkPkludGVudGlvbiB0byBUcmVhdCBBbmFseXNpczwva2V5d29yZD48a2V5

d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3b3JkPk1pZGRsZSBBZ2VkPC9rZXl3b3JkPjxrZXl3b3Jk

Pk1pbmltYWxseSBJbnZhc2l2ZSBTdXJnaWNhbCBQcm9jZWR1cmVzPC9rZXl3b3JkPjxrZXl3b3Jk

Pk1pdHJhbCBWYWx2ZS8qc3VyZ2VyeTwva2V5d29yZD48a2V5d29yZD5NaXRyYWwgVmFsdmUgSW5z

dWZmaWNpZW5jeS9jbGFzc2lmaWNhdGlvbi9tb3J0YWxpdHkvKnN1cmdlcnkvKnRoZXJhcHk8L2tl

eXdvcmQ+PGtleXdvcmQ+UG9zdG9wZXJhdGl2ZSBDb21wbGljYXRpb25zPC9rZXl3b3JkPjxrZXl3

b3JkPlByb3N0aGVzaXMgRGVzaWduPC9rZXl3b3JkPjxrZXl3b3JkPlF1YWxpdHkgb2YgTGlmZTwv

a2V5d29yZD48a2V5d29yZD5SZXRyZWF0bWVudDwva2V5d29yZD48a2V5d29yZD5UcmVhdG1lbnQg

T3V0Y29tZTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDExPC95ZWFyPjxwdWIt

ZGF0ZXM+PGRhdGU+QXByIDE0PC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTUzMy00

NDA2IChFbGVjdHJvbmljKSYjeEQ7MDAyOC00NzkzIChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9u

LW51bT4yMTQ2MzE1NDwvYWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0

cHM6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMjE0NjMxNTQ8L3VybD48L3JlbGF0ZWQt

dXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEwNTYvTkVKTW9hMTAwOTM1

NTwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT4A

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5GZWxkbWFuPC9BdXRob3I+PFllYXI+MjAxMTwvWWVhcj48

UmVjTnVtPjQxODwvUmVjTnVtPjxEaXNwbGF5VGV4dD4oMSk8L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+

PHJlYy1udW1iZXI+NDE4PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBk

Yi1pZD0iOXdlZXI1eDBxZHN0MDVldGYyMTV0eHI1emFzdnRydHRzMHo1IiB0aW1lc3RhbXA9IjE1

ODA0NjU3MjAiPjQxODwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFs

IEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+RmVs

ZG1hbiwgVC48L2F1dGhvcj48YXV0aG9yPkZvc3RlciwgRS48L2F1dGhvcj48YXV0aG9yPkdsb3dl

ciwgRC4gRC48L2F1dGhvcj48YXV0aG9yPkthciwgUy48L2F1dGhvcj48YXV0aG9yPlJpbmFsZGks

IE0uIEouPC9hdXRob3I+PGF1dGhvcj5GYWlsLCBQLiBTLjwvYXV0aG9yPjxhdXRob3I+U21hbGxp

bmcsIFIuIFcuPC9hdXRob3I+PGF1dGhvcj5TaWVnZWwsIFIuPC9hdXRob3I+PGF1dGhvcj5Sb3Nl

LCBHLiBBLjwvYXV0aG9yPjxhdXRob3I+RW5nZXJvbiwgRS48L2F1dGhvcj48YXV0aG9yPkxvZ2hp

biwgQy48L2F1dGhvcj48YXV0aG9yPlRyZW50bywgQS48L2F1dGhvcj48YXV0aG9yPlNraXBwZXIs

IEUuIFIuPC9hdXRob3I+PGF1dGhvcj5GdWRnZSwgVC48L2F1dGhvcj48YXV0aG9yPkxldHNvdSwg

Ry4gVi48L2F1dGhvcj48YXV0aG9yPk1hc3Nhcm8sIEouIE0uPC9hdXRob3I+PGF1dGhvcj5NYXVy

aSwgTC48L2F1dGhvcj48YXV0aG9yPkV2ZXJlc3QgSWkgSW52ZXN0aWdhdG9yczwvYXV0aG9yPjwv

YXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkV2YW5zdG9uIEhvc3BpdGFsLCBO

b3J0aFNob3JlIFVuaXZlcnNpdHkgSGVhbHRoIFN5c3RlbSwgRXZhbnN0b24sIElMIDYwMjAxLCBV

U0EuIHRmZWxkbWFuQG5vcnRoc2hvcmUub3JnPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+

UGVyY3V0YW5lb3VzIHJlcGFpciBvciBzdXJnZXJ5IGZvciBtaXRyYWwgcmVndXJnaXRhdGlvbjwv

dGl0bGU+PHNlY29uZGFyeS10aXRsZT5OIEVuZ2wgSiBNZWQ8L3NlY29uZGFyeS10aXRsZT48L3Rp

dGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5OIEVuZ2wgSiBNZWQ8L2Z1bGwtdGl0bGU+PC9w

ZXJpb2RpY2FsPjxwYWdlcz4xMzk1LTQwNjwvcGFnZXM+PHZvbHVtZT4zNjQ8L3ZvbHVtZT48bnVt

YmVyPjE1PC9udW1iZXI+PGVkaXRpb24+MjAxMS8wNC8wNjwvZWRpdGlvbj48a2V5d29yZHM+PGtl

eXdvcmQ+QWdlZDwva2V5d29yZD48a2V5d29yZD5GZW1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+SGVh

cnQgRmFpbHVyZS9lcGlkZW1pb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+SGVhcnQgVmFsdmUgUHJv

c3RoZXNpcyBJbXBsYW50YXRpb24vKm1ldGhvZHM8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9r

ZXl3b3JkPjxrZXl3b3JkPkludGVudGlvbiB0byBUcmVhdCBBbmFseXNpczwva2V5d29yZD48a2V5

d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3b3JkPk1pZGRsZSBBZ2VkPC9rZXl3b3JkPjxrZXl3b3Jk

Pk1pbmltYWxseSBJbnZhc2l2ZSBTdXJnaWNhbCBQcm9jZWR1cmVzPC9rZXl3b3JkPjxrZXl3b3Jk

Pk1pdHJhbCBWYWx2ZS8qc3VyZ2VyeTwva2V5d29yZD48a2V5d29yZD5NaXRyYWwgVmFsdmUgSW5z

dWZmaWNpZW5jeS9jbGFzc2lmaWNhdGlvbi9tb3J0YWxpdHkvKnN1cmdlcnkvKnRoZXJhcHk8L2tl

eXdvcmQ+PGtleXdvcmQ+UG9zdG9wZXJhdGl2ZSBDb21wbGljYXRpb25zPC9rZXl3b3JkPjxrZXl3

b3JkPlByb3N0aGVzaXMgRGVzaWduPC9rZXl3b3JkPjxrZXl3b3JkPlF1YWxpdHkgb2YgTGlmZTwv

a2V5d29yZD48a2V5d29yZD5SZXRyZWF0bWVudDwva2V5d29yZD48a2V5d29yZD5UcmVhdG1lbnQg

T3V0Y29tZTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDExPC95ZWFyPjxwdWIt

ZGF0ZXM+PGRhdGU+QXByIDE0PC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTUzMy00

NDA2IChFbGVjdHJvbmljKSYjeEQ7MDAyOC00NzkzIChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9u

LW51bT4yMTQ2MzE1NDwvYWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0

cHM6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMjE0NjMxNTQ8L3VybD48L3JlbGF0ZWQt

dXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEwNTYvTkVKTW9hMTAwOTM1

NTwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT4A

ADDIN EN.CITE.DATA (1), Secondary MR: COAPT, MITRA-FR PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5PYmFkaWE8L0F1dGhvcj48WWVhcj4yMDE4PC9ZZWFyPjxS

ZWNOdW0+NDI0PC9SZWNOdW0+PERpc3BsYXlUZXh0PigyLCAzKTwvRGlzcGxheVRleHQ+PHJlY29y

ZD48cmVjLW51bWJlcj40MjQ8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4i

IGRiLWlkPSI5d2VlcjV4MHFkc3QwNWV0ZjIxNXR4cjV6YXN2dHJ0dHMwejUiIHRpbWVzdGFtcD0i

MTU4MDQ2Nzk3NiI+NDI0PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJu

YWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5P

YmFkaWEsIEouIEYuPC9hdXRob3I+PGF1dGhvcj5NZXNzaWthLVplaXRvdW4sIEQuPC9hdXRob3I+

PGF1dGhvcj5MZXVyZW50LCBHLjwvYXV0aG9yPjxhdXRob3I+SXVuZywgQi48L2F1dGhvcj48YXV0

aG9yPkJvbm5ldCwgRy48L2F1dGhvcj48YXV0aG9yPlBpcmlvdSwgTi48L2F1dGhvcj48YXV0aG9y

PkxlZmV2cmUsIFQuPC9hdXRob3I+PGF1dGhvcj5QaW90LCBDLjwvYXV0aG9yPjxhdXRob3I+Um91

bGVhdSwgRi48L2F1dGhvcj48YXV0aG9yPkNhcnJpZSwgRC48L2F1dGhvcj48YXV0aG9yPk5lamph

cmksIE0uPC9hdXRob3I+PGF1dGhvcj5PaGxtYW5uLCBQLjwvYXV0aG9yPjxhdXRob3I+TGVjbGVy

Y3EsIEYuPC9hdXRob3I+PGF1dGhvcj5TYWludCBFdGllbm5lLCBDLjwvYXV0aG9yPjxhdXRob3I+

VGVpZ2VyLCBFLjwvYXV0aG9yPjxhdXRob3I+TGVyb3V4LCBMLjwvYXV0aG9yPjxhdXRob3I+S2Fy

YW0sIE4uPC9hdXRob3I+PGF1dGhvcj5NaWNoZWwsIE4uPC9hdXRob3I+PGF1dGhvcj5HaWxhcmQs

IE0uPC9hdXRob3I+PGF1dGhvcj5Eb25hbCwgRS48L2F1dGhvcj48YXV0aG9yPlRyb2NodSwgSi4g

Ti48L2F1dGhvcj48YXV0aG9yPkNvcm1pZXIsIEIuPC9hdXRob3I+PGF1dGhvcj5Bcm1vaXJ5LCBY

LjwvYXV0aG9yPjxhdXRob3I+Qm91dGl0aWUsIEYuPC9hdXRob3I+PGF1dGhvcj5NYXVjb3J0LUJv

dWxjaCwgRC48L2F1dGhvcj48YXV0aG9yPkJhcm5lbCwgQy48L2F1dGhvcj48YXV0aG9yPlNhbXNv

biwgRy48L2F1dGhvcj48YXV0aG9yPkd1ZXJpbiwgUC48L2F1dGhvcj48YXV0aG9yPlZhaGFuaWFu

LCBBLjwvYXV0aG9yPjxhdXRob3I+TWV3dG9uLCBOLjwvYXV0aG9yPjxhdXRob3I+TWl0cmEtRnIg

SW52ZXN0aWdhdG9yczwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRy

ZXNzPkZyb20gSG9waXRhbCBDYXJkaW92YXNjdWxhaXJlIExvdWlzIFByYWRlbCwgQ2hpcnVyZ2ll

IENhcmRpby1WYXNjdWxhaXJlIGV0IFRyYW5zcGxhbnRhdGlvbiBDYXJkaWFxdWUgKEouLUYuTy4p

LCBQaGFybWFjeSBEZXBhcnRtZW50IGFuZCBMYWJvcmF0b2lyZSBNYXRlaXMgKFguQS4pLCBhbmQg

SG9waXRhbCBDYXJkaW92YXNjdWxhaXJlIExvdWlzIFByYWRlbCwgQ2xpbmljYWwgSW52ZXN0aWdh

dGlvbiBDZW50ZXIgYW5kIEhlYXJ0IEZhaWx1cmUgRGVwYXJ0bWVudCwgSU5TRVJNIDE0MDcgKEMu

Qi4sIEcuUy4sIE4uIE1ld3RvbiksIEhvc3BpY2VzIENpdmlscyBkZSBMeW9uIGFuZCBDbGF1ZGUg

QmVybmFyZCBVbml2ZXJzaXR5LCBMeW9uLCBBc3Npc3RhbmNlIFB1YmxpcXVlLUhvcGl0YXV4IGRl

IFBhcmlzIChBUEhQKSwgSG9waXRhbCBCaWNoYXQgKEQuTS4tWi4sIEIuSS4sIEEuVi4pLCBhbmQg

QVBIUCwgSG9waXRhbCBFdXJvcGVlbiBHZW9yZ2VzIFBvbXBpZG91IChOLksuKSwgUGFyaXMsIENl

bnRyZSBIb3NwaXRhbGllciBVbml2ZXJzaXRhaXJlIChDSFUpIFJlbm5lcywgSG9waXRhbCBQb250

Y2hhaWxsb3UsIFJlbm5lcyAoRy5MLiwgRS5ELiksIEFzc2lzdGFuY2UgUHVibGlxdWUtSG9waXRh

dXggZGUgTWFyc2VpbGxlIChBUEhNKSwgSG9waXRhbCBkZSBsYSBUaW1vbmUgKEcuQi4pLCBhbmQg

SG9waXRhbCBTYWludCBKb3NlcGggKE4uIE1pY2hlbCksIE1hcnNlaWxsZSwgQ0hVIE5hbnRlcywg

SG9waXRhbCBHdWlsbGF1bWUgZXQgUmVuZSBMYWVubmVjLCBOYW50ZXMgKE4uUC4sIEouLU4uVC4s

IFAuRy4pLCBJbnN0aXR1dCBKYWNxdWVzIENhcnRpZXIsIE1hc3N5IChULkwuLCBCLkMuKSwgQ2xp

bmlxdWUgZHUgTWlsbGVuYWlyZSAoQy5QLikgYW5kIENIVSBNb250cGVsbGllciwgSG9waXRhbCBB

cm5hdWQtZGUtVmlsbGVuZXV2ZSAoRi5MLiksIE1vbnRwZWxsaWVyLCBDSFUgQW5nZXJzLCBBbmdl

cnMgKEYuUi4pLCBDSFUgVG91bG91c2UsIEhvcGl0YWwgUmFuZ3VlaWwsIFRvdWxvdXNlIChELkMu

KSwgQ2VudHJlIENhcmRpb2xvZ2lxdWUgZHUgTm9yZCwgU2FpbnQtRGVuaXMgKE0uTi4pLCBIb3Bp

dGF1eCBVbml2ZXJzaXRhaXJlcyBkZSBTdHJhc2JvdXJnLCBOb3V2ZWwgSG9waXRhbCBDaXZpbCwg

U3RyYXNib3VyZyAoUC5PLiksIENlbnRyZSBIb3NwaXRhbGllciBSZWdpb25hbCBVbml2ZXJzaXRh

aXJlIChDSFJVKSBkZSBUb3VycywgSG9waXRhbCBUcm91c3NlYXUsIFRvdXJzIChDLlMuRS4pLCBB

UEhQLCBIb3BpdGFsIEhlbnJpIE1vbmRvciwgQ3JldGVpbCAoRS5ULiksIENIVSBCb3JkZWF1eCwg

SG9waXRhbCBIYXV0LUxldmVxdWUsIFBlc3NhYyAoTC5MLiksIENIUlUgQnJlc3QsIEhvcGl0YWwg

ZGUgTGEgQ2F2YWxlIEJsYW5jaGUsIEJyZXN0IChNLkcuKSwgYW5kIFNlcnZpY2UgZGUgQmlvc3Rh

dGlzdGlxdWUtQmlvaW5mb3JtYXRpcXVlLCBQb2xlIFNhbnRlIFB1YmxpcXVlLCBIb3NwaWNlcyBD

aXZpbHMgZGUgTHlvbiwgQ2VudHJlIE5hdGlvbmFsIGRlIGxhIFJlY2hlcmNoZSBTY2llbnRpZmlx

dWUgKENOUlMpLCBhbmQgTGFib3JhdG9pcmUgZGUgQmlvbWV0cmllIGV0IEJpb2xvZ2llIEV2b2x1

dGl2ZSwgRXF1aXBlIEJpb3N0YXRpc3RpcXVlLVNhbnRlLCBWaWxsZXVyYmFubmUgKEYuQi4sIEQu

TS4tQi4pIC0gYWxsIGluIEZyYW5jZTsgYW5kIHRoZSBVbml2ZXJzaXR5IG9mIE90dGF3YSBIZWFy

dCBJbnN0aXR1dGUsIERpdmlzaW9uIG9mIENhcmRpb2xvZ3ksIE90dGF3YSwgQ2FuYWRhIChELk0u

LVouKS48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5QZXJjdXRhbmVvdXMgUmVwYWlyIG9y

IE1lZGljYWwgVHJlYXRtZW50IGZvciBTZWNvbmRhcnkgTWl0cmFsIFJlZ3VyZ2l0YXRpb248L3Rp

dGxlPjxzZWNvbmRhcnktdGl0bGU+TiBFbmdsIEogTWVkPC9zZWNvbmRhcnktdGl0bGU+PC90aXRs

ZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+TiBFbmdsIEogTWVkPC9mdWxsLXRpdGxlPjwvcGVy

aW9kaWNhbD48cGFnZXM+MjI5Ny0yMzA2PC9wYWdlcz48dm9sdW1lPjM3OTwvdm9sdW1lPjxudW1i

ZXI+MjQ8L251bWJlcj48ZWRpdGlvbj4yMDE4LzA4LzI4PC9lZGl0aW9uPjxrZXl3b3Jkcz48a2V5

d29yZD5BZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPkFnZWQsIDgwIGFuZCBvdmVyPC9rZXl3b3JkPjxr

ZXl3b3JkPkNvbWJpbmVkIE1vZGFsaXR5IFRoZXJhcHk8L2tleXdvcmQ+PGtleXdvcmQ+RmVtYWxl

PC9rZXl3b3JkPjxrZXl3b3JkPkhlYXJ0IEZhaWx1cmUvZXRpb2xvZ3kvbW9ydGFsaXR5L3RoZXJh

cHk8L2tleXdvcmQ+PGtleXdvcmQ+SGVhcnQgVmFsdmUgUHJvc3RoZXNpcy9hZHZlcnNlIGVmZmVj

dHM8L2tleXdvcmQ+PGtleXdvcmQ+KkhlYXJ0IFZhbHZlIFByb3N0aGVzaXMgSW1wbGFudGF0aW9u

L2FkdmVyc2UgZWZmZWN0czwva2V5d29yZD48a2V5d29yZD5Ib3NwaXRhbGl6YXRpb24vc3RhdGlz

dGljcyAmYW1wOyBudW1lcmljYWwgZGF0YTwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdv

cmQ+PGtleXdvcmQ+SW50ZW50aW9uIHRvIFRyZWF0IEFuYWx5c2lzPC9rZXl3b3JkPjxrZXl3b3Jk

PkthcGxhbi1NZWllciBFc3RpbWF0ZTwva2V5d29yZD48a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxr

ZXl3b3JkPk1pZGRsZSBBZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPk1pdHJhbCBWYWx2ZS9zdXJnZXJ5

PC9rZXl3b3JkPjxrZXl3b3JkPk1pdHJhbCBWYWx2ZSBJbnN1ZmZpY2llbmN5LypkcnVnIHRoZXJh

cHkvbW9ydGFsaXR5LypzdXJnZXJ5PC9rZXl3b3JkPjxrZXl3b3JkPipQZXJjdXRhbmVvdXMgQ29y

b25hcnkgSW50ZXJ2ZW50aW9uPC9rZXl3b3JkPjxrZXl3b3JkPlByb3N0aGVzaXMgRmFpbHVyZTwv

a2V5d29yZD48a2V5d29yZD5TdHJva2UgVm9sdW1lPC9rZXl3b3JkPjxrZXl3b3JkPlRyZWF0bWVu

dCBPdXRjb21lPC9rZXl3b3JkPjxrZXl3b3JkPlZlbnRyaWN1bGFyIER5c2Z1bmN0aW9uLCBMZWZ0

L2V0aW9sb2d5PC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTg8L3llYXI+PHB1

Yi1kYXRlcz48ZGF0ZT5EZWMgMTM8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNTMz

LTQ0MDYgKEVsZWN0cm9uaWMpJiN4RDswMDI4LTQ3OTMgKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Np

b24tbnVtPjMwMTQ1OTI3PC9hY2Nlc3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5o

dHRwczovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8zMDE0NTkyNzwvdXJsPjwvcmVsYXRl

ZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTA1Ni9ORUpNb2ExODA1

Mzc0PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhv

cj5TdG9uZTwvQXV0aG9yPjxZZWFyPjIwMTg8L1llYXI+PFJlY051bT40MjI8L1JlY051bT48cmVj

b3JkPjxyZWMtbnVtYmVyPjQyMjwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJF

TiIgZGItaWQ9Ijl3ZWVyNXgwcWRzdDA1ZXRmMjE1dHhyNXphc3Z0cnR0czB6NSIgdGltZXN0YW1w

PSIxNTgwNDY3ODc1Ij40MjI8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91

cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9y

PlN0b25lLCBHLiBXLjwvYXV0aG9yPjxhdXRob3I+TGluZGVuZmVsZCwgSi48L2F1dGhvcj48YXV0

aG9yPkFicmFoYW0sIFcuIFQuPC9hdXRob3I+PGF1dGhvcj5LYXIsIFMuPC9hdXRob3I+PGF1dGhv

cj5MaW0sIEQuIFMuPC9hdXRob3I+PGF1dGhvcj5NaXNoZWxsLCBKLiBNLjwvYXV0aG9yPjxhdXRo

b3I+V2hpc2VuYW50LCBCLjwvYXV0aG9yPjxhdXRob3I+R3JheWJ1cm4sIFAuIEEuPC9hdXRob3I+

PGF1dGhvcj5SaW5hbGRpLCBNLjwvYXV0aG9yPjxhdXRob3I+S2FwYWRpYSwgUy4gUi48L2F1dGhv

cj48YXV0aG9yPlJhamFnb3BhbCwgVi48L2F1dGhvcj48YXV0aG9yPlNhcmVtYm9jaywgSS4gSi48

L2F1dGhvcj48YXV0aG9yPkJyaWVrZSwgQS48L2F1dGhvcj48YXV0aG9yPk1hcngsIFMuIE8uPC9h

dXRob3I+PGF1dGhvcj5Db2hlbiwgRC4gSi48L2F1dGhvcj48YXV0aG9yPldlaXNzbWFuLCBOLiBK

LjwvYXV0aG9yPjxhdXRob3I+TWFjaywgTS4gSi48L2F1dGhvcj48YXV0aG9yPkNvYXB0IEludmVz

dGlnYXRvcnM8L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5G

cm9tIE5ldyBZb3JrLVByZXNieXRlcmlhbiBIb3NwaXRhbCBhbmQgdGhlIENhcmRpb3Zhc2N1bGFy

IFJlc2VhcmNoIEZvdW5kYXRpb24gKEcuVy5TLikgYW5kIENvbHVtYmlhIFVuaXZlcnNpdHkgTWVk

aWNhbCBDZW50ZXIgKEcuVy5TLiwgUy5PLk0uKSwgTmV3IFlvcms7IEFkdmFuY2VkIEhlYXJ0IEZh

aWx1cmUsIFZhbmRlcmJpbHQgSGVhcnQgYW5kIFZhc2N1bGFyIEluc3RpdHV0ZSwgTmFzaHZpbGxl

IChKLkwuKTsgdGhlIERlcGFydG1lbnRzIG9mIE1lZGljaW5lLCBQaHlzaW9sb2d5LCBhbmQgQ2Vs

bCBCaW9sb2d5LCBEaXZpc2lvbiBvZiBDYXJkaW92YXNjdWxhciBNZWRpY2luZSwgYW5kIHRoZSBE

YXZpcyBIZWFydCBhbmQgTHVuZyBSZXNlYXJjaCBJbnN0aXR1dGUsIE9oaW8gU3RhdGUgVW5pdmVy

c2l0eSwgQ29sdW1idXMgKFcuVC5BLiksIHRoZSBEZXBhcnRtZW50IG9mIENhcmRpb3Zhc2N1bGFy

IE1lZGljaW5lLCBIZWFydCBhbmQgVmFzY3VsYXIgSW5zdGl0dXRlLCBDbGV2ZWxhbmQgQ2xpbmlj

LCBDbGV2ZWxhbmQgKFMuUi5LLiksIGFuZCBDaHJpc3QgSG9zcGl0YWwsIENpbmNpbm5hdGkgKEku

Si5TLikgLSBhbGwgaW4gT2hpbzsgU21pZHQgSGVhcnQgSW5zdGl0dXRlLCBDZWRhcnMtU2luYWkg

TWVkaWNhbCBDZW50ZXIsIExvcyBBbmdlbGVzIChTLksuKSwgYW5kIEthaXNlciBQZXJtYW5lbnRl

LVNhbiBGcmFuY2lzY28gSG9zcGl0YWwsIFNhbiBGcmFuY2lzY28gKEouTS5NLikgLSBib3RoIGlu

IENhbGlmb3JuaWE7IHRoZSBEaXZpc2lvbiBvZiBDYXJkaW9sb2d5LCBVbml2ZXJzaXR5IG9mIFZp

cmdpbmlhLCBDaGFybG90dGVzdmlsbGUgKEQuUy5MLik7IEludGVybW91bnRhaW4gTWVkaWNhbCBD

ZW50ZXIsIE11cnJheSwgVVQgKEIuVy4pOyBCYXlsb3IgVW5pdmVyc2l0eSBNZWRpY2FsIENlbnRl

ciwgQmF5bG9yIEhlYXJ0IGFuZCBWYXNjdWxhciBJbnN0aXR1dGUsIERhbGxhcyAoUC5BLkcuKSwg

YW5kIEJheWxvciBTY290dCBhbmQgV2hpdGUgSGVhcnQgSG9zcGl0YWwgUGxhbm8sIFBsYW5vIChN

LkouTS4pIC0gYm90aCBpbiBUZXhhczsgQ2Fyb2xpbmFzIE1lZGljYWwgQ2VudGVyLCBDaGFybG90

dGUsIE5DIChNLlIuKTsgUGllZG1vbnQgSG9zcGl0YWwsIEF0bGFudGEgKFYuUi4pOyBVbml2ZXJz

aXR5IG9mIENvbG9yYWRvIEhvc3BpdGFsLCBBdXJvcmEgKEEuQi4pOyBTYWludCBMdWtlJmFwb3M7

cyBNaWQgQW1lcmljYSBIZWFydCBJbnN0aXR1dGUsIFVuaXZlcnNpdHkgb2YgTWlzc291cmktS2Fu

c2FzIENpdHkgU2Nob29sIG9mIE1lZGljaW5lLCBLYW5zYXMgQ2l0eSAoRC5KLkMuKTsgYW5kIE1l

ZFN0YXIgSGVhbHRoIFJlc2VhcmNoIEluc3RpdHV0ZSwgSHlhdHRzdmlsbGUsIE1EIChOLkouVy4p

LjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPlRyYW5zY2F0aGV0ZXIgTWl0cmFsLVZhbHZl

IFJlcGFpciBpbiBQYXRpZW50cyB3aXRoIEhlYXJ0IEZhaWx1cmU8L3RpdGxlPjxzZWNvbmRhcnkt

dGl0bGU+TiBFbmdsIEogTWVkPC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+

PGZ1bGwtdGl0bGU+TiBFbmdsIEogTWVkPC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48cGFnZXM+

MjMwNy0yMzE4PC9wYWdlcz48dm9sdW1lPjM3OTwvdm9sdW1lPjxudW1iZXI+MjQ8L251bWJlcj48

ZWRpdGlvbj4yMDE4LzEwLzA0PC9lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5BZ2VkPC9rZXl3

b3JkPjxrZXl3b3JkPkFnZWQsIDgwIGFuZCBvdmVyPC9rZXl3b3JkPjxrZXl3b3JkPkNvbWJpbmVk

IE1vZGFsaXR5IFRoZXJhcHk8L2tleXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3

b3JkPkhlYXJ0IEZhaWx1cmUvZXRpb2xvZ3kvbW9ydGFsaXR5L3N1cmdlcnk8L2tleXdvcmQ+PGtl

eXdvcmQ+SGVhcnQgVmFsdmUgUHJvc3RoZXNpcy9hZHZlcnNlIGVmZmVjdHM8L2tleXdvcmQ+PGtl

eXdvcmQ+KkhlYXJ0IFZhbHZlIFByb3N0aGVzaXMgSW1wbGFudGF0aW9uL2FkdmVyc2UgZWZmZWN0

czwva2V5d29yZD48a2V5d29yZD5Ib3NwaXRhbGl6YXRpb24vc3RhdGlzdGljcyAmYW1wOyBudW1l

cmljYWwgZGF0YTwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+SW50

ZW50aW9uIHRvIFRyZWF0IEFuYWx5c2lzPC9rZXl3b3JkPjxrZXl3b3JkPkthcGxhbi1NZWllciBF

c3RpbWF0ZTwva2V5d29yZD48a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3b3JkPk1pZGRsZSBB

Z2VkPC9rZXl3b3JkPjxrZXl3b3JkPk1pdHJhbCBWYWx2ZS9zdXJnZXJ5PC9rZXl3b3JkPjxrZXl3

b3JkPk1pdHJhbCBWYWx2ZSBJbnN1ZmZpY2llbmN5L2RydWcgdGhlcmFweS9tb3J0YWxpdHkvKnN1

cmdlcnk8L2tleXdvcmQ+PGtleXdvcmQ+UGVyY3V0YW5lb3VzIENvcm9uYXJ5IEludGVydmVudGlv

bjwva2V5d29yZD48a2V5d29yZD5Qcm9zdGhlc2lzIEZhaWx1cmU8L2tleXdvcmQ+PGtleXdvcmQ+

U3Ryb2tlIFZvbHVtZTwva2V5d29yZD48a2V5d29yZD5UcmVhdG1lbnQgT3V0Y29tZTwva2V5d29y

ZD48a2V5d29yZD5WZW50cmljdWxhciBEeXNmdW5jdGlvbiwgTGVmdC9ldGlvbG9neTwva2V5d29y

ZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDE4PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+RGVj

IDEzPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTUzMy00NDA2IChFbGVjdHJvbmlj

KSYjeEQ7MDAyOC00NzkzIChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4zMDI4MDY0MDwv

YWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cHM6Ly93d3cubmNiaS5u

bG0ubmloLmdvdi9wdWJtZWQvMzAyODA2NDA8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGVs

ZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEwNTYvTkVKTW9hMTgwNjY0MDwvZWxlY3Ryb25pYy1y

ZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT4A

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5PYmFkaWE8L0F1dGhvcj48WWVhcj4yMDE4PC9ZZWFyPjxS

ZWNOdW0+NDI0PC9SZWNOdW0+PERpc3BsYXlUZXh0PigyLCAzKTwvRGlzcGxheVRleHQ+PHJlY29y

ZD48cmVjLW51bWJlcj40MjQ8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4i

IGRiLWlkPSI5d2VlcjV4MHFkc3QwNWV0ZjIxNXR4cjV6YXN2dHJ0dHMwejUiIHRpbWVzdGFtcD0i

MTU4MDQ2Nzk3NiI+NDI0PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJu

YWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5P

YmFkaWEsIEouIEYuPC9hdXRob3I+PGF1dGhvcj5NZXNzaWthLVplaXRvdW4sIEQuPC9hdXRob3I+

PGF1dGhvcj5MZXVyZW50LCBHLjwvYXV0aG9yPjxhdXRob3I+SXVuZywgQi48L2F1dGhvcj48YXV0

aG9yPkJvbm5ldCwgRy48L2F1dGhvcj48YXV0aG9yPlBpcmlvdSwgTi48L2F1dGhvcj48YXV0aG9y

PkxlZmV2cmUsIFQuPC9hdXRob3I+PGF1dGhvcj5QaW90LCBDLjwvYXV0aG9yPjxhdXRob3I+Um91

bGVhdSwgRi48L2F1dGhvcj48YXV0aG9yPkNhcnJpZSwgRC48L2F1dGhvcj48YXV0aG9yPk5lamph

cmksIE0uPC9hdXRob3I+PGF1dGhvcj5PaGxtYW5uLCBQLjwvYXV0aG9yPjxhdXRob3I+TGVjbGVy

Y3EsIEYuPC9hdXRob3I+PGF1dGhvcj5TYWludCBFdGllbm5lLCBDLjwvYXV0aG9yPjxhdXRob3I+

VGVpZ2VyLCBFLjwvYXV0aG9yPjxhdXRob3I+TGVyb3V4LCBMLjwvYXV0aG9yPjxhdXRob3I+S2Fy

YW0sIE4uPC9hdXRob3I+PGF1dGhvcj5NaWNoZWwsIE4uPC9hdXRob3I+PGF1dGhvcj5HaWxhcmQs

IE0uPC9hdXRob3I+PGF1dGhvcj5Eb25hbCwgRS48L2F1dGhvcj48YXV0aG9yPlRyb2NodSwgSi4g

Ti48L2F1dGhvcj48YXV0aG9yPkNvcm1pZXIsIEIuPC9hdXRob3I+PGF1dGhvcj5Bcm1vaXJ5LCBY

LjwvYXV0aG9yPjxhdXRob3I+Qm91dGl0aWUsIEYuPC9hdXRob3I+PGF1dGhvcj5NYXVjb3J0LUJv

dWxjaCwgRC48L2F1dGhvcj48YXV0aG9yPkJhcm5lbCwgQy48L2F1dGhvcj48YXV0aG9yPlNhbXNv

biwgRy48L2F1dGhvcj48YXV0aG9yPkd1ZXJpbiwgUC48L2F1dGhvcj48YXV0aG9yPlZhaGFuaWFu

LCBBLjwvYXV0aG9yPjxhdXRob3I+TWV3dG9uLCBOLjwvYXV0aG9yPjxhdXRob3I+TWl0cmEtRnIg

SW52ZXN0aWdhdG9yczwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRy

ZXNzPkZyb20gSG9waXRhbCBDYXJkaW92YXNjdWxhaXJlIExvdWlzIFByYWRlbCwgQ2hpcnVyZ2ll

IENhcmRpby1WYXNjdWxhaXJlIGV0IFRyYW5zcGxhbnRhdGlvbiBDYXJkaWFxdWUgKEouLUYuTy4p

LCBQaGFybWFjeSBEZXBhcnRtZW50IGFuZCBMYWJvcmF0b2lyZSBNYXRlaXMgKFguQS4pLCBhbmQg

SG9waXRhbCBDYXJkaW92YXNjdWxhaXJlIExvdWlzIFByYWRlbCwgQ2xpbmljYWwgSW52ZXN0aWdh

dGlvbiBDZW50ZXIgYW5kIEhlYXJ0IEZhaWx1cmUgRGVwYXJ0bWVudCwgSU5TRVJNIDE0MDcgKEMu

Qi4sIEcuUy4sIE4uIE1ld3RvbiksIEhvc3BpY2VzIENpdmlscyBkZSBMeW9uIGFuZCBDbGF1ZGUg

QmVybmFyZCBVbml2ZXJzaXR5LCBMeW9uLCBBc3Npc3RhbmNlIFB1YmxpcXVlLUhvcGl0YXV4IGRl

IFBhcmlzIChBUEhQKSwgSG9waXRhbCBCaWNoYXQgKEQuTS4tWi4sIEIuSS4sIEEuVi4pLCBhbmQg

QVBIUCwgSG9waXRhbCBFdXJvcGVlbiBHZW9yZ2VzIFBvbXBpZG91IChOLksuKSwgUGFyaXMsIENl

bnRyZSBIb3NwaXRhbGllciBVbml2ZXJzaXRhaXJlIChDSFUpIFJlbm5lcywgSG9waXRhbCBQb250

Y2hhaWxsb3UsIFJlbm5lcyAoRy5MLiwgRS5ELiksIEFzc2lzdGFuY2UgUHVibGlxdWUtSG9waXRh

dXggZGUgTWFyc2VpbGxlIChBUEhNKSwgSG9waXRhbCBkZSBsYSBUaW1vbmUgKEcuQi4pLCBhbmQg

SG9waXRhbCBTYWludCBKb3NlcGggKE4uIE1pY2hlbCksIE1hcnNlaWxsZSwgQ0hVIE5hbnRlcywg

SG9waXRhbCBHdWlsbGF1bWUgZXQgUmVuZSBMYWVubmVjLCBOYW50ZXMgKE4uUC4sIEouLU4uVC4s

IFAuRy4pLCBJbnN0aXR1dCBKYWNxdWVzIENhcnRpZXIsIE1hc3N5IChULkwuLCBCLkMuKSwgQ2xp

bmlxdWUgZHUgTWlsbGVuYWlyZSAoQy5QLikgYW5kIENIVSBNb250cGVsbGllciwgSG9waXRhbCBB

cm5hdWQtZGUtVmlsbGVuZXV2ZSAoRi5MLiksIE1vbnRwZWxsaWVyLCBDSFUgQW5nZXJzLCBBbmdl

cnMgKEYuUi4pLCBDSFUgVG91bG91c2UsIEhvcGl0YWwgUmFuZ3VlaWwsIFRvdWxvdXNlIChELkMu

KSwgQ2VudHJlIENhcmRpb2xvZ2lxdWUgZHUgTm9yZCwgU2FpbnQtRGVuaXMgKE0uTi4pLCBIb3Bp

dGF1eCBVbml2ZXJzaXRhaXJlcyBkZSBTdHJhc2JvdXJnLCBOb3V2ZWwgSG9waXRhbCBDaXZpbCwg

U3RyYXNib3VyZyAoUC5PLiksIENlbnRyZSBIb3NwaXRhbGllciBSZWdpb25hbCBVbml2ZXJzaXRh

aXJlIChDSFJVKSBkZSBUb3VycywgSG9waXRhbCBUcm91c3NlYXUsIFRvdXJzIChDLlMuRS4pLCBB

UEhQLCBIb3BpdGFsIEhlbnJpIE1vbmRvciwgQ3JldGVpbCAoRS5ULiksIENIVSBCb3JkZWF1eCwg

SG9waXRhbCBIYXV0LUxldmVxdWUsIFBlc3NhYyAoTC5MLiksIENIUlUgQnJlc3QsIEhvcGl0YWwg

ZGUgTGEgQ2F2YWxlIEJsYW5jaGUsIEJyZXN0IChNLkcuKSwgYW5kIFNlcnZpY2UgZGUgQmlvc3Rh

dGlzdGlxdWUtQmlvaW5mb3JtYXRpcXVlLCBQb2xlIFNhbnRlIFB1YmxpcXVlLCBIb3NwaWNlcyBD

aXZpbHMgZGUgTHlvbiwgQ2VudHJlIE5hdGlvbmFsIGRlIGxhIFJlY2hlcmNoZSBTY2llbnRpZmlx

dWUgKENOUlMpLCBhbmQgTGFib3JhdG9pcmUgZGUgQmlvbWV0cmllIGV0IEJpb2xvZ2llIEV2b2x1

dGl2ZSwgRXF1aXBlIEJpb3N0YXRpc3RpcXVlLVNhbnRlLCBWaWxsZXVyYmFubmUgKEYuQi4sIEQu

TS4tQi4pIC0gYWxsIGluIEZyYW5jZTsgYW5kIHRoZSBVbml2ZXJzaXR5IG9mIE90dGF3YSBIZWFy

dCBJbnN0aXR1dGUsIERpdmlzaW9uIG9mIENhcmRpb2xvZ3ksIE90dGF3YSwgQ2FuYWRhIChELk0u

LVouKS48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5QZXJjdXRhbmVvdXMgUmVwYWlyIG9y

IE1lZGljYWwgVHJlYXRtZW50IGZvciBTZWNvbmRhcnkgTWl0cmFsIFJlZ3VyZ2l0YXRpb248L3Rp

dGxlPjxzZWNvbmRhcnktdGl0bGU+TiBFbmdsIEogTWVkPC9zZWNvbmRhcnktdGl0bGU+PC90aXRs

ZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+TiBFbmdsIEogTWVkPC9mdWxsLXRpdGxlPjwvcGVy

aW9kaWNhbD48cGFnZXM+MjI5Ny0yMzA2PC9wYWdlcz48dm9sdW1lPjM3OTwvdm9sdW1lPjxudW1i

ZXI+MjQ8L251bWJlcj48ZWRpdGlvbj4yMDE4LzA4LzI4PC9lZGl0aW9uPjxrZXl3b3Jkcz48a2V5

d29yZD5BZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPkFnZWQsIDgwIGFuZCBvdmVyPC9rZXl3b3JkPjxr

ZXl3b3JkPkNvbWJpbmVkIE1vZGFsaXR5IFRoZXJhcHk8L2tleXdvcmQ+PGtleXdvcmQ+RmVtYWxl

PC9rZXl3b3JkPjxrZXl3b3JkPkhlYXJ0IEZhaWx1cmUvZXRpb2xvZ3kvbW9ydGFsaXR5L3RoZXJh

cHk8L2tleXdvcmQ+PGtleXdvcmQ+SGVhcnQgVmFsdmUgUHJvc3RoZXNpcy9hZHZlcnNlIGVmZmVj

dHM8L2tleXdvcmQ+PGtleXdvcmQ+KkhlYXJ0IFZhbHZlIFByb3N0aGVzaXMgSW1wbGFudGF0aW9u

L2FkdmVyc2UgZWZmZWN0czwva2V5d29yZD48a2V5d29yZD5Ib3NwaXRhbGl6YXRpb24vc3RhdGlz

dGljcyAmYW1wOyBudW1lcmljYWwgZGF0YTwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdv

cmQ+PGtleXdvcmQ+SW50ZW50aW9uIHRvIFRyZWF0IEFuYWx5c2lzPC9rZXl3b3JkPjxrZXl3b3Jk

PkthcGxhbi1NZWllciBFc3RpbWF0ZTwva2V5d29yZD48a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxr

ZXl3b3JkPk1pZGRsZSBBZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPk1pdHJhbCBWYWx2ZS9zdXJnZXJ5

PC9rZXl3b3JkPjxrZXl3b3JkPk1pdHJhbCBWYWx2ZSBJbnN1ZmZpY2llbmN5LypkcnVnIHRoZXJh

cHkvbW9ydGFsaXR5LypzdXJnZXJ5PC9rZXl3b3JkPjxrZXl3b3JkPipQZXJjdXRhbmVvdXMgQ29y

b25hcnkgSW50ZXJ2ZW50aW9uPC9rZXl3b3JkPjxrZXl3b3JkPlByb3N0aGVzaXMgRmFpbHVyZTwv

a2V5d29yZD48a2V5d29yZD5TdHJva2UgVm9sdW1lPC9rZXl3b3JkPjxrZXl3b3JkPlRyZWF0bWVu

dCBPdXRjb21lPC9rZXl3b3JkPjxrZXl3b3JkPlZlbnRyaWN1bGFyIER5c2Z1bmN0aW9uLCBMZWZ0

L2V0aW9sb2d5PC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTg8L3llYXI+PHB1

Yi1kYXRlcz48ZGF0ZT5EZWMgMTM8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xNTMz

LTQ0MDYgKEVsZWN0cm9uaWMpJiN4RDswMDI4LTQ3OTMgKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Np

b24tbnVtPjMwMTQ1OTI3PC9hY2Nlc3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5o

dHRwczovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8zMDE0NTkyNzwvdXJsPjwvcmVsYXRl

ZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTA1Ni9ORUpNb2ExODA1

Mzc0PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhv

cj5TdG9uZTwvQXV0aG9yPjxZZWFyPjIwMTg8L1llYXI+PFJlY051bT40MjI8L1JlY051bT48cmVj

b3JkPjxyZWMtbnVtYmVyPjQyMjwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJF

TiIgZGItaWQ9Ijl3ZWVyNXgwcWRzdDA1ZXRmMjE1dHhyNXphc3Z0cnR0czB6NSIgdGltZXN0YW1w

PSIxNTgwNDY3ODc1Ij40MjI8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91

cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9y

PlN0b25lLCBHLiBXLjwvYXV0aG9yPjxhdXRob3I+TGluZGVuZmVsZCwgSi48L2F1dGhvcj48YXV0

aG9yPkFicmFoYW0sIFcuIFQuPC9hdXRob3I+PGF1dGhvcj5LYXIsIFMuPC9hdXRob3I+PGF1dGhv

cj5MaW0sIEQuIFMuPC9hdXRob3I+PGF1dGhvcj5NaXNoZWxsLCBKLiBNLjwvYXV0aG9yPjxhdXRo

b3I+V2hpc2VuYW50LCBCLjwvYXV0aG9yPjxhdXRob3I+R3JheWJ1cm4sIFAuIEEuPC9hdXRob3I+

PGF1dGhvcj5SaW5hbGRpLCBNLjwvYXV0aG9yPjxhdXRob3I+S2FwYWRpYSwgUy4gUi48L2F1dGhv

cj48YXV0aG9yPlJhamFnb3BhbCwgVi48L2F1dGhvcj48YXV0aG9yPlNhcmVtYm9jaywgSS4gSi48

L2F1dGhvcj48YXV0aG9yPkJyaWVrZSwgQS48L2F1dGhvcj48YXV0aG9yPk1hcngsIFMuIE8uPC9h

dXRob3I+PGF1dGhvcj5Db2hlbiwgRC4gSi48L2F1dGhvcj48YXV0aG9yPldlaXNzbWFuLCBOLiBK

LjwvYXV0aG9yPjxhdXRob3I+TWFjaywgTS4gSi48L2F1dGhvcj48YXV0aG9yPkNvYXB0IEludmVz

dGlnYXRvcnM8L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5G

cm9tIE5ldyBZb3JrLVByZXNieXRlcmlhbiBIb3NwaXRhbCBhbmQgdGhlIENhcmRpb3Zhc2N1bGFy

IFJlc2VhcmNoIEZvdW5kYXRpb24gKEcuVy5TLikgYW5kIENvbHVtYmlhIFVuaXZlcnNpdHkgTWVk

aWNhbCBDZW50ZXIgKEcuVy5TLiwgUy5PLk0uKSwgTmV3IFlvcms7IEFkdmFuY2VkIEhlYXJ0IEZh

aWx1cmUsIFZhbmRlcmJpbHQgSGVhcnQgYW5kIFZhc2N1bGFyIEluc3RpdHV0ZSwgTmFzaHZpbGxl

IChKLkwuKTsgdGhlIERlcGFydG1lbnRzIG9mIE1lZGljaW5lLCBQaHlzaW9sb2d5LCBhbmQgQ2Vs

bCBCaW9sb2d5LCBEaXZpc2lvbiBvZiBDYXJkaW92YXNjdWxhciBNZWRpY2luZSwgYW5kIHRoZSBE

YXZpcyBIZWFydCBhbmQgTHVuZyBSZXNlYXJjaCBJbnN0aXR1dGUsIE9oaW8gU3RhdGUgVW5pdmVy

c2l0eSwgQ29sdW1idXMgKFcuVC5BLiksIHRoZSBEZXBhcnRtZW50IG9mIENhcmRpb3Zhc2N1bGFy

IE1lZGljaW5lLCBIZWFydCBhbmQgVmFzY3VsYXIgSW5zdGl0dXRlLCBDbGV2ZWxhbmQgQ2xpbmlj

LCBDbGV2ZWxhbmQgKFMuUi5LLiksIGFuZCBDaHJpc3QgSG9zcGl0YWwsIENpbmNpbm5hdGkgKEku

Si5TLikgLSBhbGwgaW4gT2hpbzsgU21pZHQgSGVhcnQgSW5zdGl0dXRlLCBDZWRhcnMtU2luYWkg

TWVkaWNhbCBDZW50ZXIsIExvcyBBbmdlbGVzIChTLksuKSwgYW5kIEthaXNlciBQZXJtYW5lbnRl

LVNhbiBGcmFuY2lzY28gSG9zcGl0YWwsIFNhbiBGcmFuY2lzY28gKEouTS5NLikgLSBib3RoIGlu

IENhbGlmb3JuaWE7IHRoZSBEaXZpc2lvbiBvZiBDYXJkaW9sb2d5LCBVbml2ZXJzaXR5IG9mIFZp

cmdpbmlhLCBDaGFybG90dGVzdmlsbGUgKEQuUy5MLik7IEludGVybW91bnRhaW4gTWVkaWNhbCBD

ZW50ZXIsIE11cnJheSwgVVQgKEIuVy4pOyBCYXlsb3IgVW5pdmVyc2l0eSBNZWRpY2FsIENlbnRl

ciwgQmF5bG9yIEhlYXJ0IGFuZCBWYXNjdWxhciBJbnN0aXR1dGUsIERhbGxhcyAoUC5BLkcuKSwg

YW5kIEJheWxvciBTY290dCBhbmQgV2hpdGUgSGVhcnQgSG9zcGl0YWwgUGxhbm8sIFBsYW5vIChN

LkouTS4pIC0gYm90aCBpbiBUZXhhczsgQ2Fyb2xpbmFzIE1lZGljYWwgQ2VudGVyLCBDaGFybG90

dGUsIE5DIChNLlIuKTsgUGllZG1vbnQgSG9zcGl0YWwsIEF0bGFudGEgKFYuUi4pOyBVbml2ZXJz

aXR5IG9mIENvbG9yYWRvIEhvc3BpdGFsLCBBdXJvcmEgKEEuQi4pOyBTYWludCBMdWtlJmFwb3M7

cyBNaWQgQW1lcmljYSBIZWFydCBJbnN0aXR1dGUsIFVuaXZlcnNpdHkgb2YgTWlzc291cmktS2Fu

c2FzIENpdHkgU2Nob29sIG9mIE1lZGljaW5lLCBLYW5zYXMgQ2l0eSAoRC5KLkMuKTsgYW5kIE1l

ZFN0YXIgSGVhbHRoIFJlc2VhcmNoIEluc3RpdHV0ZSwgSHlhdHRzdmlsbGUsIE1EIChOLkouVy4p

LjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPlRyYW5zY2F0aGV0ZXIgTWl0cmFsLVZhbHZl

IFJlcGFpciBpbiBQYXRpZW50cyB3aXRoIEhlYXJ0IEZhaWx1cmU8L3RpdGxlPjxzZWNvbmRhcnkt

dGl0bGU+TiBFbmdsIEogTWVkPC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+

PGZ1bGwtdGl0bGU+TiBFbmdsIEogTWVkPC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48cGFnZXM+

MjMwNy0yMzE4PC9wYWdlcz48dm9sdW1lPjM3OTwvdm9sdW1lPjxudW1iZXI+MjQ8L251bWJlcj48

ZWRpdGlvbj4yMDE4LzEwLzA0PC9lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5BZ2VkPC9rZXl3

b3JkPjxrZXl3b3JkPkFnZWQsIDgwIGFuZCBvdmVyPC9rZXl3b3JkPjxrZXl3b3JkPkNvbWJpbmVk

IE1vZGFsaXR5IFRoZXJhcHk8L2tleXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3

b3JkPkhlYXJ0IEZhaWx1cmUvZXRpb2xvZ3kvbW9ydGFsaXR5L3N1cmdlcnk8L2tleXdvcmQ+PGtl

eXdvcmQ+SGVhcnQgVmFsdmUgUHJvc3RoZXNpcy9hZHZlcnNlIGVmZmVjdHM8L2tleXdvcmQ+PGtl

eXdvcmQ+KkhlYXJ0IFZhbHZlIFByb3N0aGVzaXMgSW1wbGFudGF0aW9uL2FkdmVyc2UgZWZmZWN0

czwva2V5d29yZD48a2V5d29yZD5Ib3NwaXRhbGl6YXRpb24vc3RhdGlzdGljcyAmYW1wOyBudW1l

cmljYWwgZGF0YTwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+SW50

ZW50aW9uIHRvIFRyZWF0IEFuYWx5c2lzPC9rZXl3b3JkPjxrZXl3b3JkPkthcGxhbi1NZWllciBF

c3RpbWF0ZTwva2V5d29yZD48a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3b3JkPk1pZGRsZSBB

Z2VkPC9rZXl3b3JkPjxrZXl3b3JkPk1pdHJhbCBWYWx2ZS9zdXJnZXJ5PC9rZXl3b3JkPjxrZXl3

b3JkPk1pdHJhbCBWYWx2ZSBJbnN1ZmZpY2llbmN5L2RydWcgdGhlcmFweS9tb3J0YWxpdHkvKnN1

cmdlcnk8L2tleXdvcmQ+PGtleXdvcmQ+UGVyY3V0YW5lb3VzIENvcm9uYXJ5IEludGVydmVudGlv

bjwva2V5d29yZD48a2V5d29yZD5Qcm9zdGhlc2lzIEZhaWx1cmU8L2tleXdvcmQ+PGtleXdvcmQ+

U3Ryb2tlIFZvbHVtZTwva2V5d29yZD48a2V5d29yZD5UcmVhdG1lbnQgT3V0Y29tZTwva2V5d29y

ZD48a2V5d29yZD5WZW50cmljdWxhciBEeXNmdW5jdGlvbiwgTGVmdC9ldGlvbG9neTwva2V5d29y

ZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDE4PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+RGVj

IDEzPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTUzMy00NDA2IChFbGVjdHJvbmlj

KSYjeEQ7MDAyOC00NzkzIChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4zMDI4MDY0MDwv

YWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cHM6Ly93d3cubmNiaS5u

bG0ubmloLmdvdi9wdWJtZWQvMzAyODA2NDA8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGVs

ZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEwNTYvTkVKTW9hMTgwNjY0MDwvZWxlY3Ryb25pYy1y

ZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT4A

ADDIN EN.CITE.DATA (2, 3)Primary MR: FDA (2013)Seconary MR:FDA (2019)PascalEdwards Lifesciences, Irvine, CA, USACoaptation enhancementTrans-septalCLASP PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MaW08L0F1dGhvcj48WWVhcj4yMDE5PC9ZZWFyPjxSZWNO

dW0+NDI4PC9SZWNOdW0+PERpc3BsYXlUZXh0Pig0KTwvRGlzcGxheVRleHQ+PHJlY29yZD48cmVj

LW51bWJlcj40Mjg8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlk

PSI5d2VlcjV4MHFkc3QwNWV0ZjIxNXR4cjV6YXN2dHJ0dHMwejUiIHRpbWVzdGFtcD0iMTU4MDQ2

ODQyOSI+NDI4PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0

aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5MaW0sIEQu

IFMuPC9hdXRob3I+PGF1dGhvcj5LYXIsIFMuPC9hdXRob3I+PGF1dGhvcj5TcGFyZ2lhcywgSy48

L2F1dGhvcj48YXV0aG9yPktpcHBlcm1hbiwgUi4gTS48L2F1dGhvcj48YXV0aG9yPk8mYXBvcztO

ZWlsbCwgVy4gVy48L2F1dGhvcj48YXV0aG9yPk5nLCBNLiBLLiBDLjwvYXV0aG9yPjxhdXRob3I+

RmFtLCBOLiBQLjwvYXV0aG9yPjxhdXRob3I+V2FsdGVycywgRC4gTC48L2F1dGhvcj48YXV0aG9y

PldlYmIsIEouIEcuPC9hdXRob3I+PGF1dGhvcj5TbWl0aCwgUi4gTC48L2F1dGhvcj48YXV0aG9y

PlJpbmFsZGksIE0uIEouPC9hdXRob3I+PGF1dGhvcj5MYXRpYiwgQS48L2F1dGhvcj48YXV0aG9y

PkNvaGVuLCBHLiBOLjwvYXV0aG9yPjxhdXRob3I+U2NoYWZlciwgVS48L2F1dGhvcj48YXV0aG9y

Pk1hcmNvZmYsIEwuPC9hdXRob3I+PGF1dGhvcj5WYW5kcmFuZ2ksIFAuPC9hdXRob3I+PGF1dGhv

cj5WZXJ0YSwgUC48L2F1dGhvcj48YXV0aG9yPkZlbGRtYW4sIFQuIEUuPC9hdXRob3I+PC9hdXRo

b3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+VW5pdmVyc2l0eSBvZiBWaXJnaW5pYSBI

ZWFsdGggU3lzdGVtIEhvc3BpdGFsLCBDaGFybG90dGVzdmlsbGUsIFZpcmdpbmlhLiBFbGVjdHJv

bmljIGFkZHJlc3M6IHNsOXBjQGhzY21haWwubWNjLnZpcmdpbmlhLmVkdS4mI3hEO0NlZGFycy1T

aW5haSBNZWRpY2FsIENlbnRlciwgTG9zIEFuZ2VsZXMsIENhbGlmb3JuaWEuJiN4RDtIeWdlaWEg

SG9zcGl0YWwsIEF0aGVucywgR3JlZWNlLiYjeEQ7QXRsYW50aWMgSGVhbHRoIFN5c3RlbSBNb3Jy

aXN0b3duIE1lZGljYWwgQ2VudGVyLCBNb3JyaXN0b3duLCBOZXcgSmVyc2V5LiYjeEQ7SGVucnkg

Rm9yZCBIb3NwaXRhbCwgRGV0cm9pdCwgTWljaGlnYW4uJiN4RDtSb3lhbCBQcmluY2UgQWxmcmVk

IEhvc3BpdGFsLCBDYW1wZXJkb3duLCBBdXN0cmFsaWEuJiN4RDtTdC4gTWljaGFlbCZhcG9zO3Mg

SG9zcGl0YWwsIFRvcm9udG8sIE9udGFyaW8sIENhbmFkYS4mI3hEO1RoZSBQcmluY2UgQ2hhcmxl

cyBIb3NwaXRhbCwgQ2hlcm1zaWRlLCBBdXN0cmFsaWEuJiN4RDtTdC4gUGF1bCZhcG9zO3MgSG9z

cGl0YWwsIFZhbmNvdXZlciwgQnJpdGlzaCBDb2x1bWJpYSwgQ2FuYWRhLiYjeEQ7VGhlIEhlYXJ0

IEhvc3BpdGFsIEJheWxvciBQbGFubywgUGxhbm8sIFRleGFzLiYjeEQ7U2FuZ2VyIEhlYXJ0ICZh

bXA7IFZhc2N1bGFyIEluc3RpdHV0ZSwgQ2hhcmxvdHRlLCBOb3J0aCBDYXJvbGluYS4mI3hEO1Nh

biBSYWZmYWVsZSBJbnN0aXR1dGUsIE1pbGFuLCBJdGFseS4mI3hEO1N1bm55YnJvb2sgSGVhbHRo

IFNjaWVuY2VzIENlbnRyZSwgVG9yb250bywgT250YXJpbywgQ2FuYWRhLiYjeEQ7TWFyaWVua3Jh

bmtlbmhhdXMsIEhhbWJ1cmcsIEdlcm1hbnkuJiN4RDtFZHdhcmRzIExpZmVzY2llbmNlcywgSXJ2

aW5lLCBDYWxpZm9ybmlhLiYjeEQ7RWR3YXJkcyBMaWZlc2NpZW5jZXMsIElydmluZSwgQ2FsaWZv

cm5pYTsgTm9ydGhTaG9yZSBVbml2ZXJzaXR5IEhlYWx0aCBTeXN0ZW0sIEV2YW5zdG9uIEhvc3Bp

dGFsLCBFdmFuc3RvbiwgSWxsaW5vaXMuPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+VHJh

bnNjYXRoZXRlciBWYWx2ZSBSZXBhaXIgZm9yIFBhdGllbnRzIFdpdGggTWl0cmFsIFJlZ3VyZ2l0

YXRpb246IDMwLURheSBSZXN1bHRzIG9mIHRoZSBDTEFTUCBTdHVkeTwvdGl0bGU+PHNlY29uZGFy

eS10aXRsZT5KQUNDIENhcmRpb3Zhc2MgSW50ZXJ2PC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+

PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+SkFDQyBDYXJkaW92YXNjIEludGVydjwvZnVsbC10aXRs

ZT48L3BlcmlvZGljYWw+PHBhZ2VzPjEzNjktMTM3ODwvcGFnZXM+PHZvbHVtZT4xMjwvdm9sdW1l

PjxudW1iZXI+MTQ8L251bWJlcj48ZWRpdGlvbj4yMDE5LzA3LzAxPC9lZGl0aW9uPjxrZXl3b3Jk

cz48a2V5d29yZD5DbGFzcDwva2V5d29yZD48a2V5d29yZD5QYXNjYWw8L2tleXdvcmQ+PGtleXdv

cmQ+bWl0cmFsIHJlZ3VyZ2l0YXRpb248L2tleXdvcmQ+PGtleXdvcmQ+bWl0cmFsIHJlcGFpcjwv

a2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDE5PC95ZWFyPjxwdWItZGF0ZXM+PGRh

dGU+SnVsIDIyPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTg3Ni03NjA1IChFbGVj

dHJvbmljKSYjeEQ7MTkzNi04Nzk4IChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4zMTI1

NTU2MjwvYWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cHM6Ly93d3cu

bmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMzEyNTU1NjI8L3VybD48L3JlbGF0ZWQtdXJscz48L3Vy

bHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEwMTYvai5qY2luLjIwMTkuMDQuMDM0PC9l

bGVjdHJvbmljLXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MaW08L0F1dGhvcj48WWVhcj4yMDE5PC9ZZWFyPjxSZWNO

dW0+NDI4PC9SZWNOdW0+PERpc3BsYXlUZXh0Pig0KTwvRGlzcGxheVRleHQ+PHJlY29yZD48cmVj

LW51bWJlcj40Mjg8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlk

PSI5d2VlcjV4MHFkc3QwNWV0ZjIxNXR4cjV6YXN2dHJ0dHMwejUiIHRpbWVzdGFtcD0iMTU4MDQ2

ODQyOSI+NDI4PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0

aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5MaW0sIEQu

IFMuPC9hdXRob3I+PGF1dGhvcj5LYXIsIFMuPC9hdXRob3I+PGF1dGhvcj5TcGFyZ2lhcywgSy48

L2F1dGhvcj48YXV0aG9yPktpcHBlcm1hbiwgUi4gTS48L2F1dGhvcj48YXV0aG9yPk8mYXBvcztO

ZWlsbCwgVy4gVy48L2F1dGhvcj48YXV0aG9yPk5nLCBNLiBLLiBDLjwvYXV0aG9yPjxhdXRob3I+

RmFtLCBOLiBQLjwvYXV0aG9yPjxhdXRob3I+V2FsdGVycywgRC4gTC48L2F1dGhvcj48YXV0aG9y

PldlYmIsIEouIEcuPC9hdXRob3I+PGF1dGhvcj5TbWl0aCwgUi4gTC48L2F1dGhvcj48YXV0aG9y

PlJpbmFsZGksIE0uIEouPC9hdXRob3I+PGF1dGhvcj5MYXRpYiwgQS48L2F1dGhvcj48YXV0aG9y

PkNvaGVuLCBHLiBOLjwvYXV0aG9yPjxhdXRob3I+U2NoYWZlciwgVS48L2F1dGhvcj48YXV0aG9y

Pk1hcmNvZmYsIEwuPC9hdXRob3I+PGF1dGhvcj5WYW5kcmFuZ2ksIFAuPC9hdXRob3I+PGF1dGhv

cj5WZXJ0YSwgUC48L2F1dGhvcj48YXV0aG9yPkZlbGRtYW4sIFQuIEUuPC9hdXRob3I+PC9hdXRo

b3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+VW5pdmVyc2l0eSBvZiBWaXJnaW5pYSBI

ZWFsdGggU3lzdGVtIEhvc3BpdGFsLCBDaGFybG90dGVzdmlsbGUsIFZpcmdpbmlhLiBFbGVjdHJv

bmljIGFkZHJlc3M6IHNsOXBjQGhzY21haWwubWNjLnZpcmdpbmlhLmVkdS4mI3hEO0NlZGFycy1T

aW5haSBNZWRpY2FsIENlbnRlciwgTG9zIEFuZ2VsZXMsIENhbGlmb3JuaWEuJiN4RDtIeWdlaWEg

SG9zcGl0YWwsIEF0aGVucywgR3JlZWNlLiYjeEQ7QXRsYW50aWMgSGVhbHRoIFN5c3RlbSBNb3Jy

aXN0b3duIE1lZGljYWwgQ2VudGVyLCBNb3JyaXN0b3duLCBOZXcgSmVyc2V5LiYjeEQ7SGVucnkg

Rm9yZCBIb3NwaXRhbCwgRGV0cm9pdCwgTWljaGlnYW4uJiN4RDtSb3lhbCBQcmluY2UgQWxmcmVk

IEhvc3BpdGFsLCBDYW1wZXJkb3duLCBBdXN0cmFsaWEuJiN4RDtTdC4gTWljaGFlbCZhcG9zO3Mg

SG9zcGl0YWwsIFRvcm9udG8sIE9udGFyaW8sIENhbmFkYS4mI3hEO1RoZSBQcmluY2UgQ2hhcmxl

cyBIb3NwaXRhbCwgQ2hlcm1zaWRlLCBBdXN0cmFsaWEuJiN4RDtTdC4gUGF1bCZhcG9zO3MgSG9z

cGl0YWwsIFZhbmNvdXZlciwgQnJpdGlzaCBDb2x1bWJpYSwgQ2FuYWRhLiYjeEQ7VGhlIEhlYXJ0

IEhvc3BpdGFsIEJheWxvciBQbGFubywgUGxhbm8sIFRleGFzLiYjeEQ7U2FuZ2VyIEhlYXJ0ICZh

bXA7IFZhc2N1bGFyIEluc3RpdHV0ZSwgQ2hhcmxvdHRlLCBOb3J0aCBDYXJvbGluYS4mI3hEO1Nh

biBSYWZmYWVsZSBJbnN0aXR1dGUsIE1pbGFuLCBJdGFseS4mI3hEO1N1bm55YnJvb2sgSGVhbHRo

IFNjaWVuY2VzIENlbnRyZSwgVG9yb250bywgT250YXJpbywgQ2FuYWRhLiYjeEQ7TWFyaWVua3Jh

bmtlbmhhdXMsIEhhbWJ1cmcsIEdlcm1hbnkuJiN4RDtFZHdhcmRzIExpZmVzY2llbmNlcywgSXJ2

aW5lLCBDYWxpZm9ybmlhLiYjeEQ7RWR3YXJkcyBMaWZlc2NpZW5jZXMsIElydmluZSwgQ2FsaWZv

cm5pYTsgTm9ydGhTaG9yZSBVbml2ZXJzaXR5IEhlYWx0aCBTeXN0ZW0sIEV2YW5zdG9uIEhvc3Bp

dGFsLCBFdmFuc3RvbiwgSWxsaW5vaXMuPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+VHJh

bnNjYXRoZXRlciBWYWx2ZSBSZXBhaXIgZm9yIFBhdGllbnRzIFdpdGggTWl0cmFsIFJlZ3VyZ2l0

YXRpb246IDMwLURheSBSZXN1bHRzIG9mIHRoZSBDTEFTUCBTdHVkeTwvdGl0bGU+PHNlY29uZGFy

eS10aXRsZT5KQUNDIENhcmRpb3Zhc2MgSW50ZXJ2PC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+

PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+SkFDQyBDYXJkaW92YXNjIEludGVydjwvZnVsbC10aXRs

ZT48L3BlcmlvZGljYWw+PHBhZ2VzPjEzNjktMTM3ODwvcGFnZXM+PHZvbHVtZT4xMjwvdm9sdW1l

PjxudW1iZXI+MTQ8L251bWJlcj48ZWRpdGlvbj4yMDE5LzA3LzAxPC9lZGl0aW9uPjxrZXl3b3Jk

cz48a2V5d29yZD5DbGFzcDwva2V5d29yZD48a2V5d29yZD5QYXNjYWw8L2tleXdvcmQ+PGtleXdv

cmQ+bWl0cmFsIHJlZ3VyZ2l0YXRpb248L2tleXdvcmQ+PGtleXdvcmQ+bWl0cmFsIHJlcGFpcjwv

a2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDE5PC95ZWFyPjxwdWItZGF0ZXM+PGRh

dGU+SnVsIDIyPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTg3Ni03NjA1IChFbGVj

dHJvbmljKSYjeEQ7MTkzNi04Nzk4IChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4zMTI1

NTU2MjwvYWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cHM6Ly93d3cu

bmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMzEyNTU1NjI8L3VybD48L3JlbGF0ZWQtdXJscz48L3Vy

bHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEwMTYvai5qY2luLjIwMTkuMDQuMDM0PC9l

bGVjdHJvbmljLXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE.DATA (4)CE mark (2019)CardiobandEdwards Lifesciences, Irvine, CA, USARing annuloplastyTrans-septalPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NYWlzYW5vPC9BdXRob3I+PFllYXI+MjAxNjwvWWVhcj48

UmVjTnVtPjQzMDwvUmVjTnVtPjxEaXNwbGF5VGV4dD4oNSk8L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+

PHJlYy1udW1iZXI+NDMwPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBk

Yi1pZD0iOXdlZXI1eDBxZHN0MDVldGYyMTV0eHI1emFzdnRydHRzMHo1IiB0aW1lc3RhbXA9IjE1

ODA0Njg1MjUiPjQzMDwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFs

IEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+TWFp

c2FubywgRi48L2F1dGhvcj48YXV0aG9yPlRhcmFtYXNzbywgTS48L2F1dGhvcj48YXV0aG9yPk5p

Y2tlbmlnLCBHLjwvYXV0aG9yPjxhdXRob3I+SGFtbWVyc3RpbmdsLCBDLjwvYXV0aG9yPjxhdXRo

b3I+VmFoYW5pYW4sIEEuPC9hdXRob3I+PGF1dGhvcj5NZXNzaWthLVplaXRvdW4sIEQuPC9hdXRo

b3I+PGF1dGhvcj5CYWxkdXMsIFMuPC9hdXRob3I+PGF1dGhvcj5IdW50Z2VidXJ0aCwgTS48L2F1

dGhvcj48YXV0aG9yPkFsZmllcmksIE8uPC9hdXRob3I+PGF1dGhvcj5Db2xvbWJvLCBBLjwvYXV0

aG9yPjxhdXRob3I+TGEgQ2FubmEsIEcuPC9hdXRob3I+PGF1dGhvcj5BZ3JpY29sYSwgRS48L2F1

dGhvcj48YXV0aG9yPlp1YmVyLCBNLjwvYXV0aG9yPjxhdXRob3I+VGFubmVyLCBGLiBDLjwvYXV0

aG9yPjxhdXRob3I+VG9waWxza3ksIFkuPC9hdXRob3I+PGF1dGhvcj5LcmVpZGVsLCBGLjwvYXV0

aG9yPjxhdXRob3I+S3VjaywgSy4gSC48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+

PGF1dGgtYWRkcmVzcz5LbGluaWsgZnVyIEhlcnotIHVuZCBHZWZhc3NjaGlydXJnaWUsIFVuaXZl

cnNpdHkgSG9zcGl0YWwgb2YgWnVyaWNoLCBVbml2ZXJzaXR5IG9mIFp1cmljaCwgSGVhcnQgQ2Vu

dGVyLCBSYW1pc3RyYXNzZSwgMTAwLCA4MDkxIFp1cmljaCwgU3dpdHplcmxhbmQgZnJhbmNlc2Nv

Lm1haXNhbm9AdXN6LmNoLiYjeEQ7S2xpbmlrIGZ1ciBIZXJ6LSB1bmQgR2VmYXNzY2hpcnVyZ2ll

LCBVbml2ZXJzaXR5IEhvc3BpdGFsIG9mIFp1cmljaCwgVW5pdmVyc2l0eSBvZiBadXJpY2gsIEhl

YXJ0IENlbnRlciwgUmFtaXN0cmFzc2UsIDEwMCwgODA5MSBadXJpY2gsIFN3aXR6ZXJsYW5kLiYj

eEQ7RGVwYXJ0bWVudCBvZiBNZWRpY2luZSBJSSwgSGVhcnQgQ2VudGVyIEJvbm4sIFVuaXZlcnNp

dHkgSG9zcGl0YWwgQm9ubiwgQm9ubiwgR2VybWFueS4mI3hEO0RlcGFydG1lbnQgb2YgQ2FyZGlv

bG9neSwgQXNzaXN0YW5jZSBQdWJsaXF1ZS1Ib3BpdGF1eCBkZSBQYXJpcywgQmljaGF0IEhvc3Bp

dGFsLCBQYXJpcywgRnJhbmNlLiYjeEQ7RGVwYXJ0bWVudCBvZiBDYXJkaW9sb2d5LCBIZWFydCBD

ZW50ZXIsIFVuaXZlcnNpdHkgSG9zcGl0YWwgQ29sb2duZSwgQ29sb2duZSwgR2VybWFueS4mI3hE

O0NhcmRpb3Zhc2N1bGFyIERlcGFydG1lbnQsIFNhbiBSYWZmYWVsZSBVbml2ZXJzaXR5IEhvc3Bp

dGFsLCBNaWxhbiwgSXRhbHkuJiN4RDtUaGUgVGVsIEF2aXYgU291cmFza3kgTWVkaWNhbCBDZW50

ZXIsIFRlbCBBdml2LCBJc3JhZWwuJiN4RDtEaXZpc2lvbiBvZiBDYXJkaW9sb2d5LCBBc2tsZXBp

b3MgS2xpbmlrIFN0LiBHZW9yZyBIb3NwaXRhbCwgSGFtYnVyZywgR2VybWFueS48L2F1dGgtYWRk

cmVzcz48dGl0bGVzPjx0aXRsZT5DYXJkaW9iYW5kLCBhIHRyYW5zY2F0aGV0ZXIgc3VyZ2ljYWwt

bGlrZSBkaXJlY3QgbWl0cmFsIHZhbHZlIGFubnVsb3BsYXN0eSBzeXN0ZW06IGVhcmx5IHJlc3Vs

dHMgb2YgdGhlIGZlYXNpYmlsaXR5IHRyaWFsPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkV1ciBI

ZWFydCBKPC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+

RXVyIEhlYXJ0IEo8L2Z1bGwtdGl0bGU+PC9wZXJpb2RpY2FsPjxwYWdlcz44MTctMjU8L3BhZ2Vz

Pjx2b2x1bWU+Mzc8L3ZvbHVtZT48bnVtYmVyPjEwPC9udW1iZXI+PGVkaXRpb24+MjAxNS8xMS8y

MTwvZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QWdlZDwva2V5d29yZD48a2V5d29yZD5DYXJk

aWFjIENhdGhldGVyaXphdGlvbi8qbWV0aG9kcy9tb3J0YWxpdHk8L2tleXdvcmQ+PGtleXdvcmQ+

RmVhc2liaWxpdHkgU3R1ZGllczwva2V5d29yZD48a2V5d29yZD5GZW1hbGU8L2tleXdvcmQ+PGtl

eXdvcmQ+SGVhcnQgVmFsdmUgUHJvc3RoZXNpczwva2V5d29yZD48a2V5d29yZD5Ib3NwaXRhbCBN

b3J0YWxpdHk8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPkludHJh

b3BlcmF0aXZlIENhcmU8L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48a2V5d29yZD5N

aXRyYWwgVmFsdmUgQW5udWxvcGxhc3R5LyptZXRob2RzL21vcnRhbGl0eTwva2V5d29yZD48a2V5

d29yZD5NaXRyYWwgVmFsdmUgSW5zdWZmaWNpZW5jeS9tb3J0YWxpdHkvKnN1cmdlcnk8L2tleXdv

cmQ+PGtleXdvcmQ+UGF0aWVudCBTYWZldHk8L2tleXdvcmQ+PGtleXdvcmQ+UHJvc3BlY3RpdmUg

U3R1ZGllczwva2V5d29yZD48a2V5d29yZD5Qcm9zdGhlc2lzIERlc2lnbjwva2V5d29yZD48a2V5

d29yZD5UcmVhdG1lbnQgT3V0Y29tZTwva2V5d29yZD48a2V5d29yZD5EaXJlY3QgYW5udWxvcGxh

c3R5PC9rZXl3b3JkPjxrZXl3b3JkPlNlY29uZGFyeSBtaXRyYWwgcmVndXJnaXRhdGlvbjwva2V5

d29yZD48a2V5d29yZD5UcmFuc2NhdGhldGVyIG1pdHJhbCByZXBhaXI8L2tleXdvcmQ+PC9rZXl3

b3Jkcz48ZGF0ZXM+PHllYXI+MjAxNjwveWVhcj48cHViLWRhdGVzPjxkYXRlPk1hciA3PC9kYXRl

PjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTUyMi05NjQ1IChFbGVjdHJvbmljKSYjeEQ7MDE5

NS02NjhYIChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4yNjU4Njc3OTwvYWNjZXNzaW9u

LW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cHM6Ly93d3cubmNiaS5ubG0ubmloLmdv

di9wdWJtZWQvMjY1ODY3Nzk8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGVsZWN0cm9uaWMt

cmVzb3VyY2UtbnVtPjEwLjEwOTMvZXVyaGVhcnRqL2VodjYwMzwvZWxlY3Ryb25pYy1yZXNvdXJj

ZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT4A

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NYWlzYW5vPC9BdXRob3I+PFllYXI+MjAxNjwvWWVhcj48

UmVjTnVtPjQzMDwvUmVjTnVtPjxEaXNwbGF5VGV4dD4oNSk8L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+

PHJlYy1udW1iZXI+NDMwPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBk

Yi1pZD0iOXdlZXI1eDBxZHN0MDVldGYyMTV0eHI1emFzdnRydHRzMHo1IiB0aW1lc3RhbXA9IjE1

ODA0Njg1MjUiPjQzMDwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFs

IEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+TWFp

c2FubywgRi48L2F1dGhvcj48YXV0aG9yPlRhcmFtYXNzbywgTS48L2F1dGhvcj48YXV0aG9yPk5p

Y2tlbmlnLCBHLjwvYXV0aG9yPjxhdXRob3I+SGFtbWVyc3RpbmdsLCBDLjwvYXV0aG9yPjxhdXRo

b3I+VmFoYW5pYW4sIEEuPC9hdXRob3I+PGF1dGhvcj5NZXNzaWthLVplaXRvdW4sIEQuPC9hdXRo

b3I+PGF1dGhvcj5CYWxkdXMsIFMuPC9hdXRob3I+PGF1dGhvcj5IdW50Z2VidXJ0aCwgTS48L2F1

dGhvcj48YXV0aG9yPkFsZmllcmksIE8uPC9hdXRob3I+PGF1dGhvcj5Db2xvbWJvLCBBLjwvYXV0

aG9yPjxhdXRob3I+TGEgQ2FubmEsIEcuPC9hdXRob3I+PGF1dGhvcj5BZ3JpY29sYSwgRS48L2F1

dGhvcj48YXV0aG9yPlp1YmVyLCBNLjwvYXV0aG9yPjxhdXRob3I+VGFubmVyLCBGLiBDLjwvYXV0

aG9yPjxhdXRob3I+VG9waWxza3ksIFkuPC9hdXRob3I+PGF1dGhvcj5LcmVpZGVsLCBGLjwvYXV0

aG9yPjxhdXRob3I+S3VjaywgSy4gSC48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+

PGF1dGgtYWRkcmVzcz5LbGluaWsgZnVyIEhlcnotIHVuZCBHZWZhc3NjaGlydXJnaWUsIFVuaXZl

cnNpdHkgSG9zcGl0YWwgb2YgWnVyaWNoLCBVbml2ZXJzaXR5IG9mIFp1cmljaCwgSGVhcnQgQ2Vu

dGVyLCBSYW1pc3RyYXNzZSwgMTAwLCA4MDkxIFp1cmljaCwgU3dpdHplcmxhbmQgZnJhbmNlc2Nv

Lm1haXNhbm9AdXN6LmNoLiYjeEQ7S2xpbmlrIGZ1ciBIZXJ6LSB1bmQgR2VmYXNzY2hpcnVyZ2ll

LCBVbml2ZXJzaXR5IEhvc3BpdGFsIG9mIFp1cmljaCwgVW5pdmVyc2l0eSBvZiBadXJpY2gsIEhl

YXJ0IENlbnRlciwgUmFtaXN0cmFzc2UsIDEwMCwgODA5MSBadXJpY2gsIFN3aXR6ZXJsYW5kLiYj

eEQ7RGVwYXJ0bWVudCBvZiBNZWRpY2luZSBJSSwgSGVhcnQgQ2VudGVyIEJvbm4sIFVuaXZlcnNp

dHkgSG9zcGl0YWwgQm9ubiwgQm9ubiwgR2VybWFueS4mI3hEO0RlcGFydG1lbnQgb2YgQ2FyZGlv

bG9neSwgQXNzaXN0YW5jZSBQdWJsaXF1ZS1Ib3BpdGF1eCBkZSBQYXJpcywgQmljaGF0IEhvc3Bp

dGFsLCBQYXJpcywgRnJhbmNlLiYjeEQ7RGVwYXJ0bWVudCBvZiBDYXJkaW9sb2d5LCBIZWFydCBD

ZW50ZXIsIFVuaXZlcnNpdHkgSG9zcGl0YWwgQ29sb2duZSwgQ29sb2duZSwgR2VybWFueS4mI3hE

O0NhcmRpb3Zhc2N1bGFyIERlcGFydG1lbnQsIFNhbiBSYWZmYWVsZSBVbml2ZXJzaXR5IEhvc3Bp

dGFsLCBNaWxhbiwgSXRhbHkuJiN4RDtUaGUgVGVsIEF2aXYgU291cmFza3kgTWVkaWNhbCBDZW50

ZXIsIFRlbCBBdml2LCBJc3JhZWwuJiN4RDtEaXZpc2lvbiBvZiBDYXJkaW9sb2d5LCBBc2tsZXBp

b3MgS2xpbmlrIFN0LiBHZW9yZyBIb3NwaXRhbCwgSGFtYnVyZywgR2VybWFueS48L2F1dGgtYWRk

cmVzcz48dGl0bGVzPjx0aXRsZT5DYXJkaW9iYW5kLCBhIHRyYW5zY2F0aGV0ZXIgc3VyZ2ljYWwt

bGlrZSBkaXJlY3QgbWl0cmFsIHZhbHZlIGFubnVsb3BsYXN0eSBzeXN0ZW06IGVhcmx5IHJlc3Vs

dHMgb2YgdGhlIGZlYXNpYmlsaXR5IHRyaWFsPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkV1ciBI

ZWFydCBKPC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+

RXVyIEhlYXJ0IEo8L2Z1bGwtdGl0bGU+PC9wZXJpb2RpY2FsPjxwYWdlcz44MTctMjU8L3BhZ2Vz

Pjx2b2x1bWU+Mzc8L3ZvbHVtZT48bnVtYmVyPjEwPC9udW1iZXI+PGVkaXRpb24+MjAxNS8xMS8y

MTwvZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QWdlZDwva2V5d29yZD48a2V5d29yZD5DYXJk

aWFjIENhdGhldGVyaXphdGlvbi8qbWV0aG9kcy9tb3J0YWxpdHk8L2tleXdvcmQ+PGtleXdvcmQ+

RmVhc2liaWxpdHkgU3R1ZGllczwva2V5d29yZD48a2V5d29yZD5GZW1hbGU8L2tleXdvcmQ+PGtl

eXdvcmQ+SGVhcnQgVmFsdmUgUHJvc3RoZXNpczwva2V5d29yZD48a2V5d29yZD5Ib3NwaXRhbCBN

b3J0YWxpdHk8L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPkludHJh

b3BlcmF0aXZlIENhcmU8L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48a2V5d29yZD5N

aXRyYWwgVmFsdmUgQW5udWxvcGxhc3R5LyptZXRob2RzL21vcnRhbGl0eTwva2V5d29yZD48a2V5

d29yZD5NaXRyYWwgVmFsdmUgSW5zdWZmaWNpZW5jeS9tb3J0YWxpdHkvKnN1cmdlcnk8L2tleXdv

cmQ+PGtleXdvcmQ+UGF0aWVudCBTYWZldHk8L2tleXdvcmQ+PGtleXdvcmQ+UHJvc3BlY3RpdmUg

U3R1ZGllczwva2V5d29yZD48a2V5d29yZD5Qcm9zdGhlc2lzIERlc2lnbjwva2V5d29yZD48a2V5

d29yZD5UcmVhdG1lbnQgT3V0Y29tZTwva2V5d29yZD48a2V5d29yZD5EaXJlY3QgYW5udWxvcGxh

c3R5PC9rZXl3b3JkPjxrZXl3b3JkPlNlY29uZGFyeSBtaXRyYWwgcmVndXJnaXRhdGlvbjwva2V5

d29yZD48a2V5d29yZD5UcmFuc2NhdGhldGVyIG1pdHJhbCByZXBhaXI8L2tleXdvcmQ+PC9rZXl3

b3Jkcz48ZGF0ZXM+PHllYXI+MjAxNjwveWVhcj48cHViLWRhdGVzPjxkYXRlPk1hciA3PC9kYXRl

PjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTUyMi05NjQ1IChFbGVjdHJvbmljKSYjeEQ7MDE5

NS02NjhYIChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT4yNjU4Njc3OTwvYWNjZXNzaW9u

LW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+aHR0cHM6Ly93d3cubmNiaS5ubG0ubmloLmdv

di9wdWJtZWQvMjY1ODY3Nzk8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGVsZWN0cm9uaWMt

cmVzb3VyY2UtbnVtPjEwLjEwOTMvZXVyaGVhcnRqL2VodjYwMzwvZWxlY3Ryb25pYy1yZXNvdXJj

ZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT4A

ADDIN EN.CITE.DATA (5)CE mark (2018)Millipede, Boston Scientific, Marlborough, MA, USARing annuloplastyTrans-septal ADDIN EN.CITE <EndNote><Cite><Author>Rogers</Author><Year>2018</Year><RecNum>508</RecNum><DisplayText>(6)</DisplayText><record><rec-number>508</rec-number><foreign-keys><key app="EN" db-id="9weer5x0qdst05etf215txr5zasvtrtts0z5" timestamp="1580727889">508</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Rogers, J. H.</author><author>Boyd, W. D.</author><author>Smith, T. W.</author><author>Bolling, S. F.</author></authors></contributors><auth-address>Division of Cardiovascular Medicine, University of California, Davis Medical Center, Sacramento, CA, USA.&#xD;Division of Cardiothoracic Surgery, University of California, Davis Medical Center, Sacramento, CA, USA.&#xD;Department of Cardiac Surgery, University of Michigan Health System, Ann Arbor, MI, USA.</auth-address><titles><title>Early experience with Millipede IRIS transcatheter mitral annuloplasty</title><secondary-title>Ann Cardiothorac Surg</secondary-title></titles><periodical><full-title>Ann Cardiothorac Surg</full-title></periodical><pages>780-786</pages><volume>7</volume><number>6</number><edition>2019/01/02</edition><keywords><keyword>Mitral regurgitation</keyword><keyword>mitral annuloplasty</keyword><keyword>transcatheter mitral valve repair</keyword><keyword>Millipede, Inc.</keyword></keywords><dates><year>2018</year><pub-dates><date>Nov</date></pub-dates></dates><isbn>2225-319X (Print)&#xD;2225-319X (Linking)</isbn><accession-num>30598893</accession-num><urls><related-urls><url>;(6)InvestigationalCarillon Mitral Contour System, Cardiac Dimensions, Inc., Kirkland WA, USARing annuloplastyTrans-jugularTITAN PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TaW1pbmlhazwvQXV0aG9yPjxZZWFyPjIwMTI8L1llYXI+

PFJlY051bT41MDk8L1JlY051bT48RGlzcGxheVRleHQ+KDcpPC9EaXNwbGF5VGV4dD48cmVjb3Jk

PjxyZWMtbnVtYmVyPjUwOTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIg

ZGItaWQ9Ijl3ZWVyNXgwcWRzdDA1ZXRmMjE1dHhyNXphc3Z0cnR0czB6NSIgdGltZXN0YW1wPSIx

NTgwNzI4NDcxIj41MDk8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5h

bCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPlNp

bWluaWFrLCBULjwvYXV0aG9yPjxhdXRob3I+V3UsIEouIEMuPC9hdXRob3I+PGF1dGhvcj5IYXVk

ZSwgTS48L2F1dGhvcj48YXV0aG9yPkhvcHBlLCBVLiBDLjwvYXV0aG9yPjxhdXRob3I+U2Fkb3dz

a2ksIEouPC9hdXRob3I+PGF1dGhvcj5MaXBpZWNraSwgSi48L2F1dGhvcj48YXV0aG9yPkZhamFk

ZXQsIEouPC9hdXRob3I+PGF1dGhvcj5TaGFoLCBBLiBNLjwvYXV0aG9yPjxhdXRob3I+RmVsZG1h

biwgVC48L2F1dGhvcj48YXV0aG9yPktheWUsIEQuIE0uPC9hdXRob3I+PGF1dGhvcj5Hb2xkYmVy

ZywgUy4gTC48L2F1dGhvcj48YXV0aG9yPkxldnksIFcuIEMuPC9hdXRob3I+PGF1dGhvcj5Tb2xv

bW9uLCBTLiBELjwvYXV0aG9yPjxhdXRob3I+UmV1dGVyLCBELiBHLjwvYXV0aG9yPjwvYXV0aG9y

cz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkRlcGFydG1lbnQgb2YgQ2FyZGlvbG9neSwg

UG96bmFuIFVuaXZlcnNpdHksIFBvem5hbiwgUG9sYW5kLjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+

PHRpdGxlPlRyZWF0bWVudCBvZiBmdW5jdGlvbmFsIG1pdHJhbCByZWd1cmdpdGF0aW9uIGJ5IHBl

cmN1dGFuZW91cyBhbm51bG9wbGFzdHk6IHJlc3VsdHMgb2YgdGhlIFRJVEFOIFRyaWFsPC90aXRs

ZT48c2Vjb25kYXJ5LXRpdGxlPkV1ciBKIEhlYXJ0IEZhaWw8L3NlY29uZGFyeS10aXRsZT48L3Rp

dGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5FdXIgSiBIZWFydCBGYWlsPC9mdWxsLXRpdGxl

PjwvcGVyaW9kaWNhbD48cGFnZXM+OTMxLTg8L3BhZ2VzPjx2b2x1bWU+MTQ8L3ZvbHVtZT48bnVt

YmVyPjg8L251bWJlcj48ZWRpdGlvbj4yMDEyLzA1LzIzPC9lZGl0aW9uPjxrZXl3b3Jkcz48a2V5

d29yZD5BbmFseXNpcyBvZiBWYXJpYW5jZTwva2V5d29yZD48a2V5d29yZD5FeGVyY2lzZSBUZXN0

PC9rZXl3b3JkPjxrZXl3b3JkPkV4ZXJjaXNlIFRvbGVyYW5jZTwva2V5d29yZD48a2V5d29yZD5G

ZW1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+SGVhbHRoIFN0YXR1cyBJbmRpY2F0b3JzPC9rZXl3b3Jk

PjxrZXl3b3JkPkhlYXJ0IEZhaWx1cmUvZGlhZ25vc3RpYyBpbWFnaW5nL3BhdGhvbG9neS8qc3Vy

Z2VyeTwva2V5d29yZD48a2V5d29yZD5IZWFydCBWYWx2ZSBQcm9zdGhlc2lzIEltcGxhbnRhdGlv

bi8qbWV0aG9kczwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+SW5j

aWRlbmNlPC9rZXl3b3JkPjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+TWlkZGxlIEFn

ZWQ8L2tleXdvcmQ+PGtleXdvcmQ+TWl0cmFsIFZhbHZlIEFubnVsb3BsYXN0eS8qbWV0aG9kczwv

a2V5d29yZD48a2V5d29yZD5NaXRyYWwgVmFsdmUgSW5zdWZmaWNpZW5jeS8qc3VyZ2VyeTwva2V5

d29yZD48a2V5d29yZD5Qcm9zcGVjdGl2ZSBTdHVkaWVzPC9rZXl3b3JkPjxrZXl3b3JkPlF1YWxp

dHkgb2YgTGlmZS9wc3ljaG9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPlJpc2sgRmFjdG9yczwva2V5

d29yZD48a2V5d29yZD5TdHJva2UgVm9sdW1lPC9rZXl3b3JkPjxrZXl3b3JkPlRpbWUgRmFjdG9y

czwva2V5d29yZD48a2V5d29yZD5VbHRyYXNvbm9ncmFwaHk8L2tleXdvcmQ+PGtleXdvcmQ+VmVu

dHJpY3VsYXIgRnVuY3Rpb24sIExlZnQ8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+

MjAxMjwveWVhcj48cHViLWRhdGVzPjxkYXRlPkF1ZzwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVz

Pjxpc2JuPjE4NzktMDg0NCAoRWxlY3Ryb25pYykmI3hEOzEzODgtOTg0MiAoTGlua2luZyk8L2lz

Ym4+PGFjY2Vzc2lvbi1udW0+MjI2MTM1ODQ8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQt

dXJscz48dXJsPmh0dHBzOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzIyNjEzNTg0PC91

cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxjdXN0b20yPlBNQzM0MDM0NzY8L2N1c3RvbTI+PGVs

ZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEwOTMvZXVyamhmL2hmczA3NjwvZWxlY3Ryb25pYy1y

ZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT4A

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TaW1pbmlhazwvQXV0aG9yPjxZZWFyPjIwMTI8L1llYXI+

PFJlY051bT41MDk8L1JlY051bT48RGlzcGxheVRleHQ+KDcpPC9EaXNwbGF5VGV4dD48cmVjb3Jk

PjxyZWMtbnVtYmVyPjUwOTwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIg

ZGItaWQ9Ijl3ZWVyNXgwcWRzdDA1ZXRmMjE1dHhyNXphc3Z0cnR0czB6NSIgdGltZXN0YW1wPSIx

NTgwNzI4NDcxIj41MDk8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5h

bCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPlNp

bWluaWFrLCBULjwvYXV0aG9yPjxhdXRob3I+V3UsIEouIEMuPC9hdXRob3I+PGF1dGhvcj5IYXVk

ZSwgTS48L2F1dGhvcj48YXV0aG9yPkhvcHBlLCBVLiBDLjwvYXV0aG9yPjxhdXRob3I+U2Fkb3dz

a2ksIEouPC9hdXRob3I+PGF1dGhvcj5MaXBpZWNraSwgSi48L2F1dGhvcj48YXV0aG9yPkZhamFk

ZXQsIEouPC9hdXRob3I+PGF1dGhvcj5TaGFoLCBBLiBNLjwvYXV0aG9yPjxhdXRob3I+RmVsZG1h

biwgVC48L2F1dGhvcj48YXV0aG9yPktheWUsIEQuIE0uPC9hdXRob3I+PGF1dGhvcj5Hb2xkYmVy

ZywgUy4gTC48L2F1dGhvcj48YXV0aG9yPkxldnksIFcuIEMuPC9hdXRob3I+PGF1dGhvcj5Tb2xv

bW9uLCBTLiBELjwvYXV0aG9yPjxhdXRob3I+UmV1dGVyLCBELiBHLjwvYXV0aG9yPjwvYXV0aG9y

cz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkRlcGFydG1lbnQgb2YgQ2FyZGlvbG9neSwg

UG96bmFuIFVuaXZlcnNpdHksIFBvem5hbiwgUG9sYW5kLjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+

PHRpdGxlPlRyZWF0bWVudCBvZiBmdW5jdGlvbmFsIG1pdHJhbCByZWd1cmdpdGF0aW9uIGJ5IHBl

cmN1dGFuZW91cyBhbm51bG9wbGFzdHk6IHJlc3VsdHMgb2YgdGhlIFRJVEFOIFRyaWFsPC90aXRs

ZT48c2Vjb25kYXJ5LXRpdGxlPkV1ciBKIEhlYXJ0IEZhaWw8L3NlY29uZGFyeS10aXRsZT48L3Rp

dGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5FdXIgSiBIZWFydCBGYWlsPC9mdWxsLXRpdGxl

PjwvcGVyaW9kaWNhbD48cGFnZXM+OTMxLTg8L3BhZ2VzPjx2b2x1bWU+MTQ8L3ZvbHVtZT48bnVt

YmVyPjg8L251bWJlcj48ZWRpdGlvbj4yMDEyLzA1LzIzPC9lZGl0aW9uPjxrZXl3b3Jkcz48a2V5

d29yZD5BbmFseXNpcyBvZiBWYXJpYW5jZTwva2V5d29yZD48a2V5d29yZD5FeGVyY2lzZSBUZXN0

PC9rZXl3b3JkPjxrZXl3b3JkPkV4ZXJjaXNlIFRvbGVyYW5jZTwva2V5d29yZD48a2V5d29yZD5G

ZW1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+SGVhbHRoIFN0YXR1cyBJbmRpY2F0b3JzPC9rZXl3b3Jk

PjxrZXl3b3JkPkhlYXJ0IEZhaWx1cmUvZGlhZ25vc3RpYyBpbWFnaW5nL3BhdGhvbG9neS8qc3Vy

Z2VyeTwva2V5d29yZD48a2V5d29yZD5IZWFydCBWYWx2ZSBQcm9zdGhlc2lzIEltcGxhbnRhdGlv

bi8qbWV0aG9kczwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+SW5j

aWRlbmNlPC9rZXl3b3JkPjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+TWlkZGxlIEFn

ZWQ8L2tleXdvcmQ+PGtleXdvcmQ+TWl0cmFsIFZhbHZlIEFubnVsb3BsYXN0eS8qbWV0aG9kczwv

a2V5d29yZD48a2V5d29yZD5NaXRyYWwgVmFsdmUgSW5zdWZmaWNpZW5jeS8qc3VyZ2VyeTwva2V5

d29yZD48a2V5d29yZD5Qcm9zcGVjdGl2ZSBTdHVkaWVzPC9rZXl3b3JkPjxrZXl3b3JkPlF1YWxp

dHkgb2YgTGlmZS9wc3ljaG9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPlJpc2sgRmFjdG9yczwva2V5

d29yZD48a2V5d29yZD5TdHJva2UgVm9sdW1lPC9rZXl3b3JkPjxrZXl3b3JkPlRpbWUgRmFjdG9y

czwva2V5d29yZD48a2V5d29yZD5VbHRyYXNvbm9ncmFwaHk8L2tleXdvcmQ+PGtleXdvcmQ+VmVu

dHJpY3VsYXIgRnVuY3Rpb24sIExlZnQ8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+

MjAxMjwveWVhcj48cHViLWRhdGVzPjxkYXRlPkF1ZzwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVz

Pjxpc2JuPjE4NzktMDg0NCAoRWxlY3Ryb25pYykmI3hEOzEzODgtOTg0MiAoTGlua2luZyk8L2lz

Ym4+PGFjY2Vzc2lvbi1udW0+MjI2MTM1ODQ8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQt

dXJscz48dXJsPmh0dHBzOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzIyNjEzNTg0PC91

cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxjdXN0b20yPlBNQzM0MDM0NzY8L2N1c3RvbTI+PGVs

ZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEwOTMvZXVyamhmL2hmczA3NjwvZWxlY3Ryb25pYy1y

ZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT4A

ADDIN EN.CITE.DATA (7)CE markNeoChordNeoChord, St. Louis Park, MN, USAChordal replacementTrans-apicalTACT PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TZWVidXJnZXI8L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFy

PjxSZWNOdW0+NDQyPC9SZWNOdW0+PERpc3BsYXlUZXh0Pig4KTwvRGlzcGxheVRleHQ+PHJlY29y

ZD48cmVjLW51bWJlcj40NDI8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4i

IGRiLWlkPSI5d2VlcjV4MHFkc3QwNWV0ZjIxNXR4cjV6YXN2dHJ0dHMwejUiIHRpbWVzdGFtcD0i

MTU4MDQ2ODY3MCI+NDQyPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJu

YWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5T

ZWVidXJnZXIsIEouPC9hdXRob3I+PGF1dGhvcj5SaW5hbGRpLCBNLjwvYXV0aG9yPjxhdXRob3I+

TmllbHNlbiwgUy4gTC48L2F1dGhvcj48YXV0aG9yPlNhbGl6em9uaSwgUy48L2F1dGhvcj48YXV0

aG9yPkxhbmdlLCBSLjwvYXV0aG9yPjxhdXRob3I+U2Nob2VuYnVyZywgTS48L2F1dGhvcj48YXV0

aG9yPkFsZmllcmksIE8uPC9hdXRob3I+PGF1dGhvcj5Cb3JnZXIsIE0uIEEuPC9hdXRob3I+PGF1

dGhvcj5Nb2hyLCBGLiBXLjwvYXV0aG9yPjxhdXRob3I+QWlkaWV0aXMsIEEuPC9hdXRob3I+PC9h

dXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+RGVwYXJ0bWVudCBvZiBDYXJkaWFj

IFN1cmdlcnksIEhlYXJ0Y2VudHJlIExlaXB6aWcsIExlaXB6aWcsIEdlcm1hbnkuIEVsZWN0cm9u

aWMgYWRkcmVzczogam9lcmcuc2VlYnVyZ2VyQG1lZGl6aW4udW5pLWxlaXB6aWcuZGUuJiN4RDtD

bGluaWMgZm9yIENhcmRpYWMgU3VyZ2VyeSwgVW5pdmVyc2l0eSBvZiBUdXJpbiwgVHVyaW4sIEl0

YWx5LiYjeEQ7RGVwYXJ0bWVudCBvZiBDYXJkaW8tdGhvcmFjaWMgYW5kIFZhc2N1bGFyIFN1cmdl

cnksIEFhcmh1cyBVbml2ZXJzaXR5LCBBYXJodXMsIERlbm1hcmsuJiN4RDtEZXBhcnRtZW50IG9m

IENhcmRpYWMgU3VyZ2VyeSwgR2VybWFuIEhlYXJ0IENlbnRyZSwgTXVuaWNoLCBHZXJtYW55LiYj

eEQ7RGVwYXJ0bWVudCBvZiBDYXJkaWFjIFN1cmdlcnksIEtlcmNraG9mZiBLbGluaWssIEJhZCBO

YXVoZWltLCBHZXJtYW55LiYjeEQ7RGVwYXJ0bWVudCBvZiBDYXJkaWFjIFN1cmdlcnksIFN0LiBS

YWZmYWVsbyBIb3NwaXRhbCwgTWlsYW4sIEl0YWx5LiYjeEQ7RGVwYXJ0bWVudCBvZiBDYXJkaWFj

IFN1cmdlcnksIEhlYXJ0Y2VudHJlIExlaXB6aWcsIExlaXB6aWcsIEdlcm1hbnkuJiN4RDtEZXBh

cnRtZW50IG9mIENhcmRpYWMgU3VyZ2VyeSwgVmlsbml1cyBVbml2ZXJzaXR5LCBWaWxuaXVzLCBM

aXRodWFuaWEuPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+T2ZmLXB1bXAgdHJhbnNhcGlj

YWwgaW1wbGFudGF0aW9uIG9mIGFydGlmaWNpYWwgbmVvLWNob3JkYWUgdG8gY29ycmVjdCBtaXRy

YWwgcmVndXJnaXRhdGlvbjogdGhlIFRBQ1QgVHJpYWwgKFRyYW5zYXBpY2FsIEFydGlmaWNpYWwg

Q2hvcmRhZSBUZW5kaW5hZSkgcHJvb2Ygb2YgY29uY2VwdDwvdGl0bGU+PHNlY29uZGFyeS10aXRs

ZT5KIEFtIENvbGwgQ2FyZGlvbDwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2Fs

PjxmdWxsLXRpdGxlPkogQW0gQ29sbCBDYXJkaW9sPC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48

cGFnZXM+OTE0LTk8L3BhZ2VzPjx2b2x1bWU+NjM8L3ZvbHVtZT48bnVtYmVyPjk8L251bWJlcj48

ZWRpdGlvbj4yMDEzLzEwLzAxPC9lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5BZ2VkPC9rZXl3

b3JkPjxrZXl3b3JkPkNhdGhldGVyaXphdGlvbjwva2V5d29yZD48a2V5d29yZD5DaG9yZGFlIFRl

bmRpbmVhZS9zdXJnZXJ5PC9rZXl3b3JkPjxrZXl3b3JkPkVxdWlwbWVudCBEZXNpZ248L2tleXdv

cmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPkhlYXJ0IFZhbHZlIFByb3N0aGVz

aXMvKmFkdmVyc2UgZWZmZWN0czwva2V5d29yZD48a2V5d29yZD5IZWFydCBWYWx2ZSBQcm9zdGhl

c2lzIEltcGxhbnRhdGlvbi9pbnN0cnVtZW50YXRpb24vKm1ldGhvZHM8L2tleXdvcmQ+PGtleXdv

cmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+TWlkZGxl

IEFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+TWl0cmFsIFZhbHZlL3N1cmdlcnk8L2tleXdvcmQ+PGtl

eXdvcmQ+TWl0cmFsIFZhbHZlIEluc3VmZmljaWVuY3kvKnN1cmdlcnk8L2tleXdvcmQ+PGtleXdv

cmQ+TWl0cmFsIFZhbHZlIFByb2xhcHNlLypzdXJnZXJ5PC9rZXl3b3JkPjxrZXl3b3JkPlBhdGll

bnQgU2FmZXR5PC9rZXl3b3JkPjxrZXl3b3JkPlByb3NwZWN0aXZlIFN0dWRpZXM8L2tleXdvcmQ+

PGtleXdvcmQ+UmVvcGVyYXRpb248L2tleXdvcmQ+PGtleXdvcmQ+U3V0dXJlIFRlY2huaXF1ZXMv

aW5zdHJ1bWVudGF0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPmhlYXJ0IGRpc2Vhc2U8L2tleXdvcmQ+

PGtleXdvcmQ+bWl0cmFsIHZhbHZlPC9rZXl3b3JkPjxrZXl3b3JkPnN1cmdlcnk8L2tleXdvcmQ+

PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxNDwveWVhcj48cHViLWRhdGVzPjxkYXRlPk1hciAx

MTwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE1NTgtMzU5NyAoRWxlY3Ryb25pYykm

I3hEOzA3MzUtMTA5NyAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MjQwNzY1Mjk8L2Fj

Y2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHBzOi8vd3d3Lm5jYmkubmxt

Lm5paC5nb3YvcHVibWVkLzI0MDc2NTI5PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVj

dHJvbmljLXJlc291cmNlLW51bT4xMC4xMDE2L2ouamFjYy4yMDEzLjA3LjA5MDwvZWxlY3Ryb25p

Yy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT4A

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TZWVidXJnZXI8L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFy

PjxSZWNOdW0+NDQyPC9SZWNOdW0+PERpc3BsYXlUZXh0Pig4KTwvRGlzcGxheVRleHQ+PHJlY29y

ZD48cmVjLW51bWJlcj40NDI8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4i

IGRiLWlkPSI5d2VlcjV4MHFkc3QwNWV0ZjIxNXR4cjV6YXN2dHJ0dHMwejUiIHRpbWVzdGFtcD0i

MTU4MDQ2ODY3MCI+NDQyPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJu

YWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5T

ZWVidXJnZXIsIEouPC9hdXRob3I+PGF1dGhvcj5SaW5hbGRpLCBNLjwvYXV0aG9yPjxhdXRob3I+

TmllbHNlbiwgUy4gTC48L2F1dGhvcj48YXV0aG9yPlNhbGl6em9uaSwgUy48L2F1dGhvcj48YXV0

aG9yPkxhbmdlLCBSLjwvYXV0aG9yPjxhdXRob3I+U2Nob2VuYnVyZywgTS48L2F1dGhvcj48YXV0

aG9yPkFsZmllcmksIE8uPC9hdXRob3I+PGF1dGhvcj5Cb3JnZXIsIE0uIEEuPC9hdXRob3I+PGF1

dGhvcj5Nb2hyLCBGLiBXLjwvYXV0aG9yPjxhdXRob3I+QWlkaWV0aXMsIEEuPC9hdXRob3I+PC9h

dXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+RGVwYXJ0bWVudCBvZiBDYXJkaWFj

IFN1cmdlcnksIEhlYXJ0Y2VudHJlIExlaXB6aWcsIExlaXB6aWcsIEdlcm1hbnkuIEVsZWN0cm9u

aWMgYWRkcmVzczogam9lcmcuc2VlYnVyZ2VyQG1lZGl6aW4udW5pLWxlaXB6aWcuZGUuJiN4RDtD

bGluaWMgZm9yIENhcmRpYWMgU3VyZ2VyeSwgVW5pdmVyc2l0eSBvZiBUdXJpbiwgVHVyaW4sIEl0

YWx5LiYjeEQ7RGVwYXJ0bWVudCBvZiBDYXJkaW8tdGhvcmFjaWMgYW5kIFZhc2N1bGFyIFN1cmdl

cnksIEFhcmh1cyBVbml2ZXJzaXR5LCBBYXJodXMsIERlbm1hcmsuJiN4RDtEZXBhcnRtZW50IG9m

IENhcmRpYWMgU3VyZ2VyeSwgR2VybWFuIEhlYXJ0IENlbnRyZSwgTXVuaWNoLCBHZXJtYW55LiYj

eEQ7RGVwYXJ0bWVudCBvZiBDYXJkaWFjIFN1cmdlcnksIEtlcmNraG9mZiBLbGluaWssIEJhZCBO

YXVoZWltLCBHZXJtYW55LiYjeEQ7RGVwYXJ0bWVudCBvZiBDYXJkaWFjIFN1cmdlcnksIFN0LiBS

YWZmYWVsbyBIb3NwaXRhbCwgTWlsYW4sIEl0YWx5LiYjeEQ7RGVwYXJ0bWVudCBvZiBDYXJkaWFj

IFN1cmdlcnksIEhlYXJ0Y2VudHJlIExlaXB6aWcsIExlaXB6aWcsIEdlcm1hbnkuJiN4RDtEZXBh

cnRtZW50IG9mIENhcmRpYWMgU3VyZ2VyeSwgVmlsbml1cyBVbml2ZXJzaXR5LCBWaWxuaXVzLCBM

aXRodWFuaWEuPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+T2ZmLXB1bXAgdHJhbnNhcGlj

YWwgaW1wbGFudGF0aW9uIG9mIGFydGlmaWNpYWwgbmVvLWNob3JkYWUgdG8gY29ycmVjdCBtaXRy

YWwgcmVndXJnaXRhdGlvbjogdGhlIFRBQ1QgVHJpYWwgKFRyYW5zYXBpY2FsIEFydGlmaWNpYWwg

Q2hvcmRhZSBUZW5kaW5hZSkgcHJvb2Ygb2YgY29uY2VwdDwvdGl0bGU+PHNlY29uZGFyeS10aXRs

ZT5KIEFtIENvbGwgQ2FyZGlvbDwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2Fs

PjxmdWxsLXRpdGxlPkogQW0gQ29sbCBDYXJkaW9sPC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48

cGFnZXM+OTE0LTk8L3BhZ2VzPjx2b2x1bWU+NjM8L3ZvbHVtZT48bnVtYmVyPjk8L251bWJlcj48

ZWRpdGlvbj4yMDEzLzEwLzAxPC9lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5BZ2VkPC9rZXl3

b3JkPjxrZXl3b3JkPkNhdGhldGVyaXphdGlvbjwva2V5d29yZD48a2V5d29yZD5DaG9yZGFlIFRl

bmRpbmVhZS9zdXJnZXJ5PC9rZXl3b3JkPjxrZXl3b3JkPkVxdWlwbWVudCBEZXNpZ248L2tleXdv

cmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPkhlYXJ0IFZhbHZlIFByb3N0aGVz

aXMvKmFkdmVyc2UgZWZmZWN0czwva2V5d29yZD48a2V5d29yZD5IZWFydCBWYWx2ZSBQcm9zdGhl

c2lzIEltcGxhbnRhdGlvbi9pbnN0cnVtZW50YXRpb24vKm1ldGhvZHM8L2tleXdvcmQ+PGtleXdv

cmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+TWlkZGxl

IEFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+TWl0cmFsIFZhbHZlL3N1cmdlcnk8L2tleXdvcmQ+PGtl

eXdvcmQ+TWl0cmFsIFZhbHZlIEluc3VmZmljaWVuY3kvKnN1cmdlcnk8L2tleXdvcmQ+PGtleXdv

cmQ+TWl0cmFsIFZhbHZlIFByb2xhcHNlLypzdXJnZXJ5PC9rZXl3b3JkPjxrZXl3b3JkPlBhdGll

bnQgU2FmZXR5PC9rZXl3b3JkPjxrZXl3b3JkPlByb3NwZWN0aXZlIFN0dWRpZXM8L2tleXdvcmQ+

PGtleXdvcmQ+UmVvcGVyYXRpb248L2tleXdvcmQ+PGtleXdvcmQ+U3V0dXJlIFRlY2huaXF1ZXMv

aW5zdHJ1bWVudGF0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPmhlYXJ0IGRpc2Vhc2U8L2tleXdvcmQ+

PGtleXdvcmQ+bWl0cmFsIHZhbHZlPC9rZXl3b3JkPjxrZXl3b3JkPnN1cmdlcnk8L2tleXdvcmQ+

PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxNDwveWVhcj48cHViLWRhdGVzPjxkYXRlPk1hciAx

MTwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE1NTgtMzU5NyAoRWxlY3Ryb25pYykm

I3hEOzA3MzUtMTA5NyAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MjQwNzY1Mjk8L2Fj

Y2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHBzOi8vd3d3Lm5jYmkubmxt

Lm5paC5nb3YvcHVibWVkLzI0MDc2NTI5PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVj

dHJvbmljLXJlc291cmNlLW51bT4xMC4xMDE2L2ouamFjYy4yMDEzLjA3LjA5MDwvZWxlY3Ryb25p

Yy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT4A

ADDIN EN.CITE.DATA (8)Investigational HarpoonEdwards Lifesciences, Irvine, CA, USAChordal replacementTrans-apicalPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5HYW1taWU8L0F1dGhvcj48WWVhcj4yMDE4PC9ZZWFyPjxS

ZWNOdW0+NDUwPC9SZWNOdW0+PERpc3BsYXlUZXh0Pig5KTwvRGlzcGxheVRleHQ+PHJlY29yZD48

cmVjLW51bWJlcj40NTA8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRi

LWlkPSI5d2VlcjV4MHFkc3QwNWV0ZjIxNXR4cjV6YXN2dHJ0dHMwejUiIHRpbWVzdGFtcD0iMTU4

MDQ2ODg5NiI+NDUwPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwg

QXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5HYW1t

aWUsIEouIFMuPC9hdXRob3I+PGF1dGhvcj5CYXJ0dXMsIEsuPC9hdXRob3I+PGF1dGhvcj5HYWNr

b3dza2ksIEEuPC9hdXRob3I+PGF1dGhvcj5EJmFwb3M7QW1icmEsIE0uIE4uPC9hdXRob3I+PGF1

dGhvcj5TenltYW5za2ksIFAuPC9hdXRob3I+PGF1dGhvcj5CaWxld3NrYSwgQS48L2F1dGhvcj48

YXV0aG9yPkt1c21pZXJjenlrLCBNLjwvYXV0aG9yPjxhdXRob3I+S2FwZWxhaywgQi48L2F1dGhv

cj48YXV0aG9yPlJ6dWNpZGxvLVJlc2lsLCBKLjwvYXV0aG9yPjxhdXRob3I+TW9hdCwgTi48L2F1

dGhvcj48YXV0aG9yPkR1bmNhbiwgQS48L2F1dGhvcj48YXV0aG9yPllhZGV2LCBSLjwvYXV0aG9y

PjxhdXRob3I+TGl2ZXNleSwgUy48L2F1dGhvcj48YXV0aG9yPkRpcHJvc2UsIFAuPC9hdXRob3I+

PGF1dGhvcj5HZXJvc2EsIEcuPC9hdXRob3I+PGF1dGhvcj5EJmFwb3M7T25vZnJpbywgQS48L2F1

dGhvcj48YXV0aG9yPlBpdHRlcmVsbG8sIEQuPC9hdXRob3I+PGF1dGhvcj5EZW50aSwgUC48L2F1

dGhvcj48YXV0aG9yPkxhIENhbm5hLCBHLjwvYXV0aG9yPjxhdXRob3I+RGUgQm9uaXMsIE0uPC9h

dXRob3I+PGF1dGhvcj5BbGZpZXJpLCBPLjwvYXV0aG9yPjxhdXRob3I+SHVuZywgSi48L2F1dGhv

cj48YXV0aG9yPktvbHN1dCwgUC48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1

dGgtYWRkcmVzcz5EaXZpc2lvbiBvZiBDYXJkaWFjIFN1cmdlcnksIFVuaXZlcnNpdHkgb2YgTWFy

eWxhbmQgU2Nob29sIG9mIE1lZGljaW5lLCBCYWx0aW1vcmUsIE1hcnlsYW5kLiBFbGVjdHJvbmlj

IGFkZHJlc3M6IEpzZ2FtbWllbWRAZ21haWwuY29tLiYjeEQ7SmFnaWVsbG9uaWFuIFVuaXZlcnNp

dHkgSm9obiBQYXVsIElJIEhvc3BpdGFsLCBLcmFrb3cgUG9sYW5kLiYjeEQ7QnJpZ2hhbSBhbmQg

V29tZW4mYXBvcztzIEhvc3BpdGFsLCBCb3N0b24sIE1hc3NhY2h1c2V0dHMuJiN4RDtJbnN0aXR1

dGUgb2YgQ2FyZGlvbG9neSwgV2Fyc2F3LCBQb2xhbmQuJiN4RDtSb3lhbCBCcm9tcHRvbiBhbmQg

SGFyZWZpZWxkIE5hdGlvbmFsIEhlYWx0aCBTZXJ2aWNlIEZvdW5kYXRpb24gVHJ1c3QsIExvbmRv

biwgVW5pdGVkIEtpbmdkb20uJiN4RDtVbml2ZXJzaXR5IEhvc3BpdGFsIFNvdXRoYW1wdG9uIE5h

dGlvbmFsIEhlYWx0aCBTZXJ2aWNlIEZvdW5kYXRpb24gVHJ1c3QsIFVuaXRlZCBLaW5nZG9tLiYj

eEQ7UGFkb3ZhIFVuaXZlcnNpdHkgSG9zcGl0YWwsIFBhZG92YSwgSXRhbHkuJiN4RDtPc3BlZGFs

ZSBTYW4gUmFmZmFlbGUsIE1pbGFuLCBJdGFseS4mI3hEO01hc3NhY2h1c2V0dHMgR2VuZXJhbCBI

b3NwaXRhbCwgQm9zdG9uLCBNYXNzYWNodXNldHRzLjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRp

dGxlPkJlYXRpbmctSGVhcnQgTWl0cmFsIFZhbHZlIFJlcGFpciBVc2luZyBhIE5vdmVsIGVQVEZF

IENvcmRhbCBJbXBsYW50YXRpb24gRGV2aWNlOiBBIFByb3NwZWN0aXZlIFRyaWFsPC90aXRsZT48

c2Vjb25kYXJ5LXRpdGxlPkogQW0gQ29sbCBDYXJkaW9sPC9zZWNvbmRhcnktdGl0bGU+PC90aXRs

ZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+SiBBbSBDb2xsIENhcmRpb2w8L2Z1bGwtdGl0bGU+

PC9wZXJpb2RpY2FsPjxwYWdlcz4yNS0zNjwvcGFnZXM+PHZvbHVtZT43MTwvdm9sdW1lPjxudW1i

ZXI+MTwvbnVtYmVyPjxlZGl0aW9uPjIwMTcvMTEvMDY8L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3

b3JkPkFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+RWNob2NhcmRpb2dyYXBoeSwgVHJhbnNlc29waGFn

ZWFsLyptZXRob2RzPC9rZXl3b3JkPjxrZXl3b3JkPkVxdWlwbWVudCBEZXNpZ248L2tleXdvcmQ+

PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPipIZWFydCBWYWx2ZSBQcm9zdGhlc2lz

IEltcGxhbnRhdGlvbi9hZHZlcnNlIGVmZmVjdHMvaW5zdHJ1bWVudGF0aW9uL21ldGhvZHM8L2tl

eXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+PGtl

eXdvcmQ+TWlkZGxlIEFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+TWl0cmFsIFZhbHZlL2RpYWdub3N0

aWMgaW1hZ2luZy9zdXJnZXJ5PC9rZXl3b3JkPjxrZXl3b3JkPk1pdHJhbCBWYWx2ZSBJbnN1ZmZp

Y2llbmN5L2RpYWdub3Npcy8qc3VyZ2VyeTwva2V5d29yZD48a2V5d29yZD5PdXRjb21lIGFuZCBQ

cm9jZXNzIEFzc2Vzc21lbnQsIEhlYWx0aCBDYXJlPC9rZXl3b3JkPjxrZXl3b3JkPlBvbHl0ZXRy

YWZsdW9yb2V0aHlsZW5lL3RoZXJhcGV1dGljIHVzZTwva2V5d29yZD48a2V5d29yZD5Qcm9zcGVj

dGl2ZSBTdHVkaWVzPC9rZXl3b3JkPjxrZXl3b3JkPlByb3N0aGVzZXMgYW5kIEltcGxhbnRzPC9r

ZXl3b3JkPjxrZXl3b3JkPipSZW9wZXJhdGlvbi9tZXRob2RzL3N0YXRpc3RpY3MgJmFtcDsgbnVt

ZXJpY2FsIGRhdGE8L2tleXdvcmQ+PGtleXdvcmQ+KlN1cmdlcnksIENvbXB1dGVyLUFzc2lzdGVk

L2FkdmVyc2UgZWZmZWN0cy9pbnN0cnVtZW50YXRpb24vbWV0aG9kczwva2V5d29yZD48a2V5d29y

ZD5UaG9yYWNvdG9teS9tZXRob2RzPC9rZXl3b3JkPjxrZXl3b3JkPiplY2hvY2FyZGlvZ3JhcGh5

PC9rZXl3b3JkPjxrZXl3b3JkPiptaXRyYWwgdmFsdmU8L2tleXdvcmQ+PGtleXdvcmQ+KnJlZ3Vy

Z2l0YXRpb248L2tleXdvcmQ+PGtleXdvcmQ+KnN1cmdlcnk8L2tleXdvcmQ+PGtleXdvcmQ+KnZh

bHZ1bG9wbGFzdHk8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxODwveWVhcj48

cHViLWRhdGVzPjxkYXRlPkphbiAyPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTU1

OC0zNTk3IChFbGVjdHJvbmljKSYjeEQ7MDczNS0xMDk3IChMaW5raW5nKTwvaXNibj48YWNjZXNz

aW9uLW51bT4yOTEwMjY4ODwvYWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+

aHR0cHM6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMjkxMDI2ODg8L3VybD48L3JlbGF0

ZWQtdXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEwMTYvai5qYWNjLjIw

MTcuMTAuMDYyPC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PC9FbmRO

b3RlPn==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5HYW1taWU8L0F1dGhvcj48WWVhcj4yMDE4PC9ZZWFyPjxS

ZWNOdW0+NDUwPC9SZWNOdW0+PERpc3BsYXlUZXh0Pig5KTwvRGlzcGxheVRleHQ+PHJlY29yZD48

cmVjLW51bWJlcj40NTA8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRi

LWlkPSI5d2VlcjV4MHFkc3QwNWV0ZjIxNXR4cjV6YXN2dHJ0dHMwejUiIHRpbWVzdGFtcD0iMTU4

MDQ2ODg5NiI+NDUwPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwg

QXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5HYW1t

aWUsIEouIFMuPC9hdXRob3I+PGF1dGhvcj5CYXJ0dXMsIEsuPC9hdXRob3I+PGF1dGhvcj5HYWNr

b3dza2ksIEEuPC9hdXRob3I+PGF1dGhvcj5EJmFwb3M7QW1icmEsIE0uIE4uPC9hdXRob3I+PGF1

dGhvcj5TenltYW5za2ksIFAuPC9hdXRob3I+PGF1dGhvcj5CaWxld3NrYSwgQS48L2F1dGhvcj48

YXV0aG9yPkt1c21pZXJjenlrLCBNLjwvYXV0aG9yPjxhdXRob3I+S2FwZWxhaywgQi48L2F1dGhv

cj48YXV0aG9yPlJ6dWNpZGxvLVJlc2lsLCBKLjwvYXV0aG9yPjxhdXRob3I+TW9hdCwgTi48L2F1

dGhvcj48YXV0aG9yPkR1bmNhbiwgQS48L2F1dGhvcj48YXV0aG9yPllhZGV2LCBSLjwvYXV0aG9y

PjxhdXRob3I+TGl2ZXNleSwgUy48L2F1dGhvcj48YXV0aG9yPkRpcHJvc2UsIFAuPC9hdXRob3I+

PGF1dGhvcj5HZXJvc2EsIEcuPC9hdXRob3I+PGF1dGhvcj5EJmFwb3M7T25vZnJpbywgQS48L2F1

dGhvcj48YXV0aG9yPlBpdHRlcmVsbG8sIEQuPC9hdXRob3I+PGF1dGhvcj5EZW50aSwgUC48L2F1

dGhvcj48YXV0aG9yPkxhIENhbm5hLCBHLjwvYXV0aG9yPjxhdXRob3I+RGUgQm9uaXMsIE0uPC9h

dXRob3I+PGF1dGhvcj5BbGZpZXJpLCBPLjwvYXV0aG9yPjxhdXRob3I+SHVuZywgSi48L2F1dGhv

cj48YXV0aG9yPktvbHN1dCwgUC48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1

dGgtYWRkcmVzcz5EaXZpc2lvbiBvZiBDYXJkaWFjIFN1cmdlcnksIFVuaXZlcnNpdHkgb2YgTWFy

eWxhbmQgU2Nob29sIG9mIE1lZGljaW5lLCBCYWx0aW1vcmUsIE1hcnlsYW5kLiBFbGVjdHJvbmlj

IGFkZHJlc3M6IEpzZ2FtbWllbWRAZ21haWwuY29tLiYjeEQ7SmFnaWVsbG9uaWFuIFVuaXZlcnNp

dHkgSm9obiBQYXVsIElJIEhvc3BpdGFsLCBLcmFrb3cgUG9sYW5kLiYjeEQ7QnJpZ2hhbSBhbmQg

V29tZW4mYXBvcztzIEhvc3BpdGFsLCBCb3N0b24sIE1hc3NhY2h1c2V0dHMuJiN4RDtJbnN0aXR1

dGUgb2YgQ2FyZGlvbG9neSwgV2Fyc2F3LCBQb2xhbmQuJiN4RDtSb3lhbCBCcm9tcHRvbiBhbmQg

SGFyZWZpZWxkIE5hdGlvbmFsIEhlYWx0aCBTZXJ2aWNlIEZvdW5kYXRpb24gVHJ1c3QsIExvbmRv

biwgVW5pdGVkIEtpbmdkb20uJiN4RDtVbml2ZXJzaXR5IEhvc3BpdGFsIFNvdXRoYW1wdG9uIE5h

dGlvbmFsIEhlYWx0aCBTZXJ2aWNlIEZvdW5kYXRpb24gVHJ1c3QsIFVuaXRlZCBLaW5nZG9tLiYj

eEQ7UGFkb3ZhIFVuaXZlcnNpdHkgSG9zcGl0YWwsIFBhZG92YSwgSXRhbHkuJiN4RDtPc3BlZGFs

ZSBTYW4gUmFmZmFlbGUsIE1pbGFuLCBJdGFseS4mI3hEO01hc3NhY2h1c2V0dHMgR2VuZXJhbCBI

b3NwaXRhbCwgQm9zdG9uLCBNYXNzYWNodXNldHRzLjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRp

dGxlPkJlYXRpbmctSGVhcnQgTWl0cmFsIFZhbHZlIFJlcGFpciBVc2luZyBhIE5vdmVsIGVQVEZF

IENvcmRhbCBJbXBsYW50YXRpb24gRGV2aWNlOiBBIFByb3NwZWN0aXZlIFRyaWFsPC90aXRsZT48

c2Vjb25kYXJ5LXRpdGxlPkogQW0gQ29sbCBDYXJkaW9sPC9zZWNvbmRhcnktdGl0bGU+PC90aXRs

ZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+SiBBbSBDb2xsIENhcmRpb2w8L2Z1bGwtdGl0bGU+

PC9wZXJpb2RpY2FsPjxwYWdlcz4yNS0zNjwvcGFnZXM+PHZvbHVtZT43MTwvdm9sdW1lPjxudW1i

ZXI+MTwvbnVtYmVyPjxlZGl0aW9uPjIwMTcvMTEvMDY8L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3

b3JkPkFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+RWNob2NhcmRpb2dyYXBoeSwgVHJhbnNlc29waGFn

ZWFsLyptZXRob2RzPC9rZXl3b3JkPjxrZXl3b3JkPkVxdWlwbWVudCBEZXNpZ248L2tleXdvcmQ+

PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPipIZWFydCBWYWx2ZSBQcm9zdGhlc2lz

IEltcGxhbnRhdGlvbi9hZHZlcnNlIGVmZmVjdHMvaW5zdHJ1bWVudGF0aW9uL21ldGhvZHM8L2tl

eXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+PGtl

eXdvcmQ+TWlkZGxlIEFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+TWl0cmFsIFZhbHZlL2RpYWdub3N0

aWMgaW1hZ2luZy9zdXJnZXJ5PC9rZXl3b3JkPjxrZXl3b3JkPk1pdHJhbCBWYWx2ZSBJbnN1ZmZp

Y2llbmN5L2RpYWdub3Npcy8qc3VyZ2VyeTwva2V5d29yZD48a2V5d29yZD5PdXRjb21lIGFuZCBQ

cm9jZXNzIEFzc2Vzc21lbnQsIEhlYWx0aCBDYXJlPC9rZXl3b3JkPjxrZXl3b3JkPlBvbHl0ZXRy

YWZsdW9yb2V0aHlsZW5lL3RoZXJhcGV1dGljIHVzZTwva2V5d29yZD48a2V5d29yZD5Qcm9zcGVj

dGl2ZSBTdHVkaWVzPC9rZXl3b3JkPjxrZXl3b3JkPlByb3N0aGVzZXMgYW5kIEltcGxhbnRzPC9r

ZXl3b3JkPjxrZXl3b3JkPipSZW9wZXJhdGlvbi9tZXRob2RzL3N0YXRpc3RpY3MgJmFtcDsgbnVt

ZXJpY2FsIGRhdGE8L2tleXdvcmQ+PGtleXdvcmQ+KlN1cmdlcnksIENvbXB1dGVyLUFzc2lzdGVk

L2FkdmVyc2UgZWZmZWN0cy9pbnN0cnVtZW50YXRpb24vbWV0aG9kczwva2V5d29yZD48a2V5d29y

ZD5UaG9yYWNvdG9teS9tZXRob2RzPC9rZXl3b3JkPjxrZXl3b3JkPiplY2hvY2FyZGlvZ3JhcGh5

PC9rZXl3b3JkPjxrZXl3b3JkPiptaXRyYWwgdmFsdmU8L2tleXdvcmQ+PGtleXdvcmQ+KnJlZ3Vy

Z2l0YXRpb248L2tleXdvcmQ+PGtleXdvcmQ+KnN1cmdlcnk8L2tleXdvcmQ+PGtleXdvcmQ+KnZh

bHZ1bG9wbGFzdHk8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxODwveWVhcj48

cHViLWRhdGVzPjxkYXRlPkphbiAyPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MTU1

OC0zNTk3IChFbGVjdHJvbmljKSYjeEQ7MDczNS0xMDk3IChMaW5raW5nKTwvaXNibj48YWNjZXNz

aW9uLW51bT4yOTEwMjY4ODwvYWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11cmxzPjx1cmw+

aHR0cHM6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMjkxMDI2ODg8L3VybD48L3JlbGF0

ZWQtdXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEwMTYvai5qYWNjLjIw

MTcuMTAuMDYyPC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PC9FbmRO

b3RlPn==

ADDIN EN.CITE.DATA (9)InvestigationalTranscatheter Mitral Valve Replacement (TMVR)Device/ManufacturerDevice characteristicsAccessStudyApprovalTendyneAbbott Strucural Heart, Santa Clara, CA, USABioprosthesis featuring tether-pad stablizationTrans-apicalPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Tb3JhamphPC9BdXRob3I+PFllYXI+MjAxOTwvWWVhcj48

UmVjTnVtPjQ2ODwvUmVjTnVtPjxEaXNwbGF5VGV4dD4oMTApPC9EaXNwbGF5VGV4dD48cmVjb3Jk

PjxyZWMtbnVtYmVyPjQ2ODwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIg

ZGItaWQ9Ijl3ZWVyNXgwcWRzdDA1ZXRmMjE1dHhyNXphc3Z0cnR0czB6NSIgdGltZXN0YW1wPSIx

NTgwNDY5MDc1Ij40Njg8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5h

bCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPlNv

cmFqamEsIFAuPC9hdXRob3I+PGF1dGhvcj5Nb2F0LCBOLjwvYXV0aG9yPjxhdXRob3I+QmFkaHdh

ciwgVi48L2F1dGhvcj48YXV0aG9yPldhbHRlcnMsIEQuPC9hdXRob3I+PGF1dGhvcj5QYW9uZSwg

Ry48L2F1dGhvcj48YXV0aG9yPkJldGhlYSwgQi48L2F1dGhvcj48YXV0aG9yPkJhZSwgUi48L2F1

dGhvcj48YXV0aG9yPkRhaGxlLCBHLjwvYXV0aG9yPjxhdXRob3I+TXVtdGF6LCBNLjwvYXV0aG9y

PjxhdXRob3I+R3JheWJ1cm4sIFAuPC9hdXRob3I+PGF1dGhvcj5LYXBhZGlhLCBTLjwvYXV0aG9y

PjxhdXRob3I+QmFiYWxpYXJvcywgVi48L2F1dGhvcj48YXV0aG9yPkd1ZXJyZXJvLCBNLjwvYXV0

aG9yPjxhdXRob3I+U2F0bGVyLCBMLjwvYXV0aG9yPjxhdXRob3I+VGhvdXJhbmksIFYuPC9hdXRo

b3I+PGF1dGhvcj5CZWRvZ25pLCBGLjwvYXV0aG9yPjxhdXRob3I+Uml6aWssIEQuPC9hdXRob3I+

PGF1dGhvcj5EZW50aSwgUC48L2F1dGhvcj48YXV0aG9yPkR1bW9udGVpbCwgTi48L2F1dGhvcj48

YXV0aG9yPk1vZGluZSwgVC48L2F1dGhvcj48YXV0aG9yPlNpbmhhbCwgQS48L2F1dGhvcj48YXV0

aG9yPkNodWFuZywgTS4gTC48L2F1dGhvcj48YXV0aG9yPlBvcG1hLCBKLiBKLjwvYXV0aG9yPjxh

dXRob3I+QmxhbmtlLCBQLjwvYXV0aG9yPjxhdXRob3I+TGVpcHNpYywgSi48L2F1dGhvcj48YXV0

aG9yPk11bGxlciwgRC48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRk

cmVzcz5WYWx2ZSBTY2llbmNlIENlbnRlciwgTWlubmVhcG9saXMgSGVhcnQgSW5zdGl0dXRlIEZv

dW5kYXRpb24gYXQgQWJib3R0IE5vcnRod2VzdGVybiBIb3NwaXRhbCwgTWlubmVhcG9saXMsIE1p

bm5lc290YS4gRWxlY3Ryb25pYyBhZGRyZXNzOiBwYXVsLnNvcmFqamFAYWxsaW5hLmNvbS4mI3hE

O1JveWFsIEJyb21wdG9uIEhvc3BpdGFsLCBMb25kb24sIFVuaXRlZCBLaW5nZG9tLiYjeEQ7V2Vz

dCBWaXJnaW5pYSBVbml2ZXJzaXR5IEhlYXJ0IGFuZCBWYXNjdWxhciBJbnN0aXR1dGUsIE1vcmdh

bnRvd24sIFdlc3QgVmlyZ2luaWEuJiN4RDtQcmluY2UgQ2hhcmxlcyBIb3NwaXRhbCwgQnJpc2Jh

bmUsIEF1c3RyYWxpYS4mI3hEO0hlbnJ5IEZvcmQgSG9zcGl0YWwsIERldHJvaXQsIE1pY2hpZ2Fu

LiYjeEQ7RGVscmF5IE1lZGljYWwgQ2VudGVyLCBEZWxyYXkgQmVhY2gsIEZsb3JpZGEuJiN4RDtW

YWx2ZSBTY2llbmNlIENlbnRlciwgTWlubmVhcG9saXMgSGVhcnQgSW5zdGl0dXRlIEZvdW5kYXRp

b24gYXQgQWJib3R0IE5vcnRod2VzdGVybiBIb3NwaXRhbCwgTWlubmVhcG9saXMsIE1pbm5lc290

YS4mI3hEO09zbG8gVW5pdmVyc2l0eSBIb3NwaXRhbCwgT3NsbywgTm9yd2F5LiYjeEQ7VW5pdmVy

c2l0eSBvZiBQaXR0c2J1cmcgTWVkaWNhbCBDZW50ZXIgUGlubmFjbGUsIEhhcnJpc2J1cmcsIFBl

bm5zeWx2YW5pYS4mI3hEO0JheWxvciBVbml2ZXJzaXR5IE1lZGljYWwgQ2VudGVyLCBEYWxsYXMs

IFRleGFzLiYjeEQ7Q2xldmVsYW5kIENsaW5pYyBGb3VuZGF0aW9uLCBDbGV2ZWxhbmQsIE9oaW8u

JiN4RDtFbW9yeSBVbml2ZXJzaXR5IEhvc3BpdGFsLCBBdGxhbnRhLCBHZW9yZ2lhLiYjeEQ7TWF5

byBDbGluaWMsIFJvY2hlc3RlciwgTWlubmVzb3RhLiYjeEQ7TWVkc3RhciBXYXNoaW5ndG9uIEhv

c3BpdGFsIENlbnRlciwgV2FzaGluZ3RvbiwgREMuJiN4RDtQb2xpY2xpbmljbyBTYW4gRG9uYXRv

LCBNaWxhbiwgSXRhbHkuJiN4RDtIb25vciBIZWFsdGgsIFNjb3R0c2RhbGUsIEFyaXpvbmEuJiN4

RDtPc3BlZGFsZSBTYW4gUmFmZmFlbGUsIE1pbGFuLCBJdGFseS4mI3hEO0NsaW5pcXVlIFBhc3Rl

dXIsIFRvdWxvdXNlLCBGcmFuY2UuJiN4RDtDSFJVIExpbGxlLCBMaWxsZSwgRnJhbmNlLiYjeEQ7

RmxpbmRlcnMgVW5pdmVyc2l0eSBIb3NwaXRhbCwgQWRlbGFpZGUsIEF1c3RyYWxpYS4mI3hEO0Jl

dGggSXNyYWVsIERlYWNvbmVzcyBNZWRpY2FsIENlbnRlciwgQm9zdG9uLCBNYXNzYWNodXNldHRz

LiYjeEQ7U3QgUGF1bCZhcG9zO3MgSG9zcGl0YWwsIFZhbmNvdXZlciwgQnJpdGlzaCBDb2x1bWJp

YSwgQ2FuYWRhLiYjeEQ7U3QuIFZpbmNlbnQmYXBvcztzIEhvc3BpdGFsLCBTeWRuZXksIEF1c3Ry

YWxpYS48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5Jbml0aWFsIEZlYXNpYmlsaXR5IFN0

dWR5IG9mIGEgTmV3IFRyYW5zY2F0aGV0ZXIgTWl0cmFsIFByb3N0aGVzaXM6IFRoZSBGaXJzdCAx

MDAgUGF0aWVudHM8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+SiBBbSBDb2xsIENhcmRpb2w8L3Nl

Y29uZGFyeS10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5KIEFtIENvbGwg

Q2FyZGlvbDwvZnVsbC10aXRsZT48L3BlcmlvZGljYWw+PHBhZ2VzPjEyNTAtMTI2MDwvcGFnZXM+

PHZvbHVtZT43Mzwvdm9sdW1lPjxudW1iZXI+MTE8L251bWJlcj48ZWRpdGlvbj4yMDE5LzAzLzIz

PC9lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5taXRyYWw8L2tleXdvcmQ+PGtleXdvcmQ+cmVn

dXJnaXRhdGlvbjwva2V5d29yZD48a2V5d29yZD5zdXJnZXJ5PC9rZXl3b3JkPjxrZXl3b3JkPnRy

YW5zY2F0aGV0ZXI8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxOTwveWVhcj48

cHViLWRhdGVzPjxkYXRlPk1hciAyNjwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE1

NTgtMzU5NyAoRWxlY3Ryb25pYykmI3hEOzA3MzUtMTA5NyAoTGlua2luZyk8L2lzYm4+PGFjY2Vz

c2lvbi1udW0+MzA4OTgyMDA8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJs

Pmh0dHBzOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzMwODk4MjAwPC91cmw+PC9yZWxh

dGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMDE2L2ouamFjYy4y

MDE4LjEyLjA2NjwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjwvRW5k

Tm90ZT4A

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Tb3JhamphPC9BdXRob3I+PFllYXI+MjAxOTwvWWVhcj48

UmVjTnVtPjQ2ODwvUmVjTnVtPjxEaXNwbGF5VGV4dD4oMTApPC9EaXNwbGF5VGV4dD48cmVjb3Jk

PjxyZWMtbnVtYmVyPjQ2ODwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIg

ZGItaWQ9Ijl3ZWVyNXgwcWRzdDA1ZXRmMjE1dHhyNXphc3Z0cnR0czB6NSIgdGltZXN0YW1wPSIx

NTgwNDY5MDc1Ij40Njg8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5h

bCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPlNv

cmFqamEsIFAuPC9hdXRob3I+PGF1dGhvcj5Nb2F0LCBOLjwvYXV0aG9yPjxhdXRob3I+QmFkaHdh

ciwgVi48L2F1dGhvcj48YXV0aG9yPldhbHRlcnMsIEQuPC9hdXRob3I+PGF1dGhvcj5QYW9uZSwg

Ry48L2F1dGhvcj48YXV0aG9yPkJldGhlYSwgQi48L2F1dGhvcj48YXV0aG9yPkJhZSwgUi48L2F1

dGhvcj48YXV0aG9yPkRhaGxlLCBHLjwvYXV0aG9yPjxhdXRob3I+TXVtdGF6LCBNLjwvYXV0aG9y

PjxhdXRob3I+R3JheWJ1cm4sIFAuPC9hdXRob3I+PGF1dGhvcj5LYXBhZGlhLCBTLjwvYXV0aG9y

PjxhdXRob3I+QmFiYWxpYXJvcywgVi48L2F1dGhvcj48YXV0aG9yPkd1ZXJyZXJvLCBNLjwvYXV0

aG9yPjxhdXRob3I+U2F0bGVyLCBMLjwvYXV0aG9yPjxhdXRob3I+VGhvdXJhbmksIFYuPC9hdXRo

b3I+PGF1dGhvcj5CZWRvZ25pLCBGLjwvYXV0aG9yPjxhdXRob3I+Uml6aWssIEQuPC9hdXRob3I+

PGF1dGhvcj5EZW50aSwgUC48L2F1dGhvcj48YXV0aG9yPkR1bW9udGVpbCwgTi48L2F1dGhvcj48

YXV0aG9yPk1vZGluZSwgVC48L2F1dGhvcj48YXV0aG9yPlNpbmhhbCwgQS48L2F1dGhvcj48YXV0

aG9yPkNodWFuZywgTS4gTC48L2F1dGhvcj48YXV0aG9yPlBvcG1hLCBKLiBKLjwvYXV0aG9yPjxh

dXRob3I+QmxhbmtlLCBQLjwvYXV0aG9yPjxhdXRob3I+TGVpcHNpYywgSi48L2F1dGhvcj48YXV0

aG9yPk11bGxlciwgRC48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRk

cmVzcz5WYWx2ZSBTY2llbmNlIENlbnRlciwgTWlubmVhcG9saXMgSGVhcnQgSW5zdGl0dXRlIEZv

dW5kYXRpb24gYXQgQWJib3R0IE5vcnRod2VzdGVybiBIb3NwaXRhbCwgTWlubmVhcG9saXMsIE1p

bm5lc290YS4gRWxlY3Ryb25pYyBhZGRyZXNzOiBwYXVsLnNvcmFqamFAYWxsaW5hLmNvbS4mI3hE

O1JveWFsIEJyb21wdG9uIEhvc3BpdGFsLCBMb25kb24sIFVuaXRlZCBLaW5nZG9tLiYjeEQ7V2Vz

dCBWaXJnaW5pYSBVbml2ZXJzaXR5IEhlYXJ0IGFuZCBWYXNjdWxhciBJbnN0aXR1dGUsIE1vcmdh

bnRvd24sIFdlc3QgVmlyZ2luaWEuJiN4RDtQcmluY2UgQ2hhcmxlcyBIb3NwaXRhbCwgQnJpc2Jh

bmUsIEF1c3RyYWxpYS4mI3hEO0hlbnJ5IEZvcmQgSG9zcGl0YWwsIERldHJvaXQsIE1pY2hpZ2Fu

LiYjeEQ7RGVscmF5IE1lZGljYWwgQ2VudGVyLCBEZWxyYXkgQmVhY2gsIEZsb3JpZGEuJiN4RDtW

YWx2ZSBTY2llbmNlIENlbnRlciwgTWlubmVhcG9saXMgSGVhcnQgSW5zdGl0dXRlIEZvdW5kYXRp

b24gYXQgQWJib3R0IE5vcnRod2VzdGVybiBIb3NwaXRhbCwgTWlubmVhcG9saXMsIE1pbm5lc290

YS4mI3hEO09zbG8gVW5pdmVyc2l0eSBIb3NwaXRhbCwgT3NsbywgTm9yd2F5LiYjeEQ7VW5pdmVy

c2l0eSBvZiBQaXR0c2J1cmcgTWVkaWNhbCBDZW50ZXIgUGlubmFjbGUsIEhhcnJpc2J1cmcsIFBl

bm5zeWx2YW5pYS4mI3hEO0JheWxvciBVbml2ZXJzaXR5IE1lZGljYWwgQ2VudGVyLCBEYWxsYXMs

IFRleGFzLiYjeEQ7Q2xldmVsYW5kIENsaW5pYyBGb3VuZGF0aW9uLCBDbGV2ZWxhbmQsIE9oaW8u

JiN4RDtFbW9yeSBVbml2ZXJzaXR5IEhvc3BpdGFsLCBBdGxhbnRhLCBHZW9yZ2lhLiYjeEQ7TWF5

byBDbGluaWMsIFJvY2hlc3RlciwgTWlubmVzb3RhLiYjeEQ7TWVkc3RhciBXYXNoaW5ndG9uIEhv

c3BpdGFsIENlbnRlciwgV2FzaGluZ3RvbiwgREMuJiN4RDtQb2xpY2xpbmljbyBTYW4gRG9uYXRv

LCBNaWxhbiwgSXRhbHkuJiN4RDtIb25vciBIZWFsdGgsIFNjb3R0c2RhbGUsIEFyaXpvbmEuJiN4

RDtPc3BlZGFsZSBTYW4gUmFmZmFlbGUsIE1pbGFuLCBJdGFseS4mI3hEO0NsaW5pcXVlIFBhc3Rl

dXIsIFRvdWxvdXNlLCBGcmFuY2UuJiN4RDtDSFJVIExpbGxlLCBMaWxsZSwgRnJhbmNlLiYjeEQ7

RmxpbmRlcnMgVW5pdmVyc2l0eSBIb3NwaXRhbCwgQWRlbGFpZGUsIEF1c3RyYWxpYS4mI3hEO0Jl

dGggSXNyYWVsIERlYWNvbmVzcyBNZWRpY2FsIENlbnRlciwgQm9zdG9uLCBNYXNzYWNodXNldHRz

LiYjeEQ7U3QgUGF1bCZhcG9zO3MgSG9zcGl0YWwsIFZhbmNvdXZlciwgQnJpdGlzaCBDb2x1bWJp

YSwgQ2FuYWRhLiYjeEQ7U3QuIFZpbmNlbnQmYXBvcztzIEhvc3BpdGFsLCBTeWRuZXksIEF1c3Ry

YWxpYS48L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5Jbml0aWFsIEZlYXNpYmlsaXR5IFN0

dWR5IG9mIGEgTmV3IFRyYW5zY2F0aGV0ZXIgTWl0cmFsIFByb3N0aGVzaXM6IFRoZSBGaXJzdCAx

MDAgUGF0aWVudHM8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+SiBBbSBDb2xsIENhcmRpb2w8L3Nl

Y29uZGFyeS10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5KIEFtIENvbGwg

Q2FyZGlvbDwvZnVsbC10aXRsZT48L3BlcmlvZGljYWw+PHBhZ2VzPjEyNTAtMTI2MDwvcGFnZXM+

PHZvbHVtZT43Mzwvdm9sdW1lPjxudW1iZXI+MTE8L251bWJlcj48ZWRpdGlvbj4yMDE5LzAzLzIz

PC9lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5taXRyYWw8L2tleXdvcmQ+PGtleXdvcmQ+cmVn

dXJnaXRhdGlvbjwva2V5d29yZD48a2V5d29yZD5zdXJnZXJ5PC9rZXl3b3JkPjxrZXl3b3JkPnRy

YW5zY2F0aGV0ZXI8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MjAxOTwveWVhcj48

cHViLWRhdGVzPjxkYXRlPk1hciAyNjwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE1

NTgtMzU5NyAoRWxlY3Ryb25pYykmI3hEOzA3MzUtMTA5NyAoTGlua2luZyk8L2lzYm4+PGFjY2Vz

c2lvbi1udW0+MzA4OTgyMDA8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJs

Pmh0dHBzOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzMwODk4MjAwPC91cmw+PC9yZWxh

dGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMDE2L2ouamFjYy4y

MDE4LjEyLjA2NjwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjwvRW5k

Tm90ZT4A

ADDIN EN.CITE.DATA (10)CE mark (2020)IntrepidMedtronic, Dublin, IrelandDual structure design: circular inner stent to and outer fixation ring.Trans-apicalPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CYXBhdDwvQXV0aG9yPjxZZWFyPjIwMTg8L1llYXI+PFJl

Y051bT40NzE8L1JlY051bT48RGlzcGxheVRleHQ+KDExKTwvRGlzcGxheVRleHQ+PHJlY29yZD48

cmVjLW51bWJlcj40NzE8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRi

LWlkPSI5d2VlcjV4MHFkc3QwNWV0ZjIxNXR4cjV6YXN2dHJ0dHMwejUiIHRpbWVzdGFtcD0iMTU4

MDQ2OTEzMyI+NDcxPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwg

QXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5CYXBh

dCwgVi48L2F1dGhvcj48YXV0aG9yPlJhamFnb3BhbCwgVi48L2F1dGhvcj48YXV0aG9yPk1lZHVy

aSwgQy48L2F1dGhvcj48YXV0aG9yPkZhcml2YXIsIFIuIFMuPC9hdXRob3I+PGF1dGhvcj5XYWx0

b24sIEEuPC9hdXRob3I+PGF1dGhvcj5EdWZmeSwgUy4gSi48L2F1dGhvcj48YXV0aG9yPkdvb2xl

eSwgUi48L2F1dGhvcj48YXV0aG9yPkFsbWVpZGEsIEEuPC9hdXRob3I+PGF1dGhvcj5SZWFyZG9u

LCBNLiBKLjwvYXV0aG9yPjxhdXRob3I+S2xlaW1hbiwgTi4gUy48L2F1dGhvcj48YXV0aG9yPlNw

YXJnaWFzLCBLLjwvYXV0aG9yPjxhdXRob3I+UGF0dGFrb3MsIFMuPC9hdXRob3I+PGF1dGhvcj5O

ZywgTS4gSy48L2F1dGhvcj48YXV0aG9yPldpbHNvbiwgTS48L2F1dGhvcj48YXV0aG9yPkFkYW1z

LCBELiBILjwvYXV0aG9yPjxhdXRob3I+TGVvbiwgTS48L2F1dGhvcj48YXV0aG9yPk1hY2ssIE0u

IEouPC9hdXRob3I+PGF1dGhvcj5DaGVub3dldGgsIFMuPC9hdXRob3I+PGF1dGhvcj5Tb3Jhamph

LCBQLjwvYXV0aG9yPjxhdXRob3I+SW50cmVwaWQgR2xvYmFsIFBpbG90IFN0dWR5LCBJbnZlc3Rp

Z2F0b3JzPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+U3Qu

IFRob21hcyZhcG9zOyBIb3NwaXRhbCwgTG9uZG9uLCBVbml0ZWQgS2luZ2RvbTsgTmV3IFlvcmsg

UHJlc2J5dGVyaWFuL0NvbHVtYmlhIFVuaXZlcnNpdHkgTWVkaWNhbCBDZW50ZXIsIE5ldyBZb3Jr

LCBOZXcgWW9yay4mI3hEO1BpZWRtb250IEhlYXJ0IEluc3RpdHV0ZSwgQXRsYW50YSwgR2Vvcmdp

YS4mI3hEO0FiYm90dCBOb3J0aHdlc3Rlcm4gSG9zcGl0YWwsIE1pbm5lYXBvbGlzLCBNaW5uZXNv

dGEuJiN4RDtDYXJkaW9sb2d5IERlcGFydG1lbnQsIFRoZSBBbGZyZWQsIE1lbGJvdXJuZSwgQXVz

dHJhbGlhLiYjeEQ7TW9uYXNoIEhlYXJ0LCBNZWxib3VybmUsIEF1c3RyYWxpYS4mI3hEO0hvdXN0

b24gTWV0aG9kaXN0IERlQmFrZXkgSGVhcnQgYW5kIFZhc2N1bGFyIENlbnRlciwgVGhlIE1ldGhv

ZGlzdCBIb3NwaXRhbCwgSG91c3RvbiwgVGV4YXMuJiN4RDtIeWdlaWEgSG9zcGl0YWwsIEF0aGVu

cywgR3JlZWNlLiYjeEQ7Um95YWwgUHJpbmNlIEFsZnJlZCBIb3NwaXRhbCwgU3lkbmV5LCBBdXN0

cmFsaWEuJiN4RDtNb3VudCBTaW5haSBNZWRpY2FsIENlbnRlciwgTmV3IFlvcmssIE5ldyBZb3Jr

LiYjeEQ7TmV3IFlvcmsgUHJlc2J5dGVyaWFuL0NvbHVtYmlhIFVuaXZlcnNpdHkgTWVkaWNhbCBD

ZW50ZXIsIE5ldyBZb3JrLCBOZXcgWW9yay4mI3hEO0JheWxvciBTY290dCAmYW1wOyBXaGl0ZSBI

ZWFsdGgsIFBsYW5vLCBUZXhhcy4mI3hEO01lZHRyb25pYywgTWlubmVhcG9saXMsIE1pbm5lc290

YS4mI3hEO0FiYm90dCBOb3J0aHdlc3Rlcm4gSG9zcGl0YWwsIE1pbm5lYXBvbGlzLCBNaW5uZXNv

dGEuIEVsZWN0cm9uaWMgYWRkcmVzczogcGF1bC5zb3JhamphQGFsbGluYS5jb20uPC9hdXRoLWFk

ZHJlc3M+PHRpdGxlcz48dGl0bGU+RWFybHkgRXhwZXJpZW5jZSBXaXRoIE5ldyBUcmFuc2NhdGhl

dGVyIE1pdHJhbCBWYWx2ZSBSZXBsYWNlbWVudDwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5KIEFt

IENvbGwgQ2FyZGlvbDwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxs

LXRpdGxlPkogQW0gQ29sbCBDYXJkaW9sPC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48cGFnZXM+

MTItMjE8L3BhZ2VzPjx2b2x1bWU+NzE8L3ZvbHVtZT48bnVtYmVyPjE8L251bWJlcj48ZWRpdGlv

bj4yMDE3LzExLzA2PC9lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5BZ2VkPC9rZXl3b3JkPjxr

ZXl3b3JkPkFnZWQsIDgwIGFuZCBvdmVyPC9rZXl3b3JkPjxrZXl3b3JkPkNhcmRpYWMgQ2F0aGV0

ZXJpemF0aW9uL21ldGhvZHM8L2tleXdvcmQ+PGtleXdvcmQ+RWNob2NhcmRpb2dyYXBoeS9tZXRo

b2RzPC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29yZD5IZWFydCBWYWx2

ZSBQcm9zdGhlc2lzLyphZHZlcnNlIGVmZmVjdHM8L2tleXdvcmQ+PGtleXdvcmQ+KkhlYXJ0IFZh

bHZlIFByb3N0aGVzaXMgSW1wbGFudGF0aW9uL2FkdmVyc2UgZWZmZWN0cy9pbnN0cnVtZW50YXRp

b24vbWV0aG9kczwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+TWFs

ZTwva2V5d29yZD48a2V5d29yZD4qTWl0cmFsIFZhbHZlL2RpYWdub3N0aWMgaW1hZ2luZy9zdXJn

ZXJ5PC9rZXl3b3JkPjxrZXl3b3JkPk1pdHJhbCBWYWx2ZSBJbnN1ZmZpY2llbmN5L2RpYWdub3Np

cy9waHlzaW9wYXRob2xvZ3kvKnN1cmdlcnk8L2tleXdvcmQ+PGtleXdvcmQ+T3V0Y29tZSBhbmQg

UHJvY2VzcyBBc3Nlc3NtZW50LCBIZWFsdGggQ2FyZTwva2V5d29yZD48a2V5d29yZD4qUG9zdG9w

ZXJhdGl2ZSBDb21wbGljYXRpb25zL2RpYWdub3Npcy9tb3J0YWxpdHkvcGh5c2lvcGF0aG9sb2d5

PC9rZXl3b3JkPjxrZXl3b3JkPlJpc2sgRmFjdG9yczwva2V5d29yZD48a2V5d29yZD5TZXZlcml0

eSBvZiBJbGxuZXNzIEluZGV4PC9rZXl3b3JkPjxrZXl3b3JkPlRpbWUgRmFjdG9yczwva2V5d29y

ZD48a2V5d29yZD5UcmVhdG1lbnQgT3V0Y29tZTwva2V5d29yZD48a2V5d29yZD5WZW50cmljdWxh

ciBGdW5jdGlvbiwgTGVmdDwva2V5d29yZD48a2V5d29yZD4qbWl0cmFsIHZhbHZlIHJlZ3VyZ2l0

YXRpb248L2tleXdvcmQ+PGtleXdvcmQ+KnByb3N0aGVzaXM8L2tleXdvcmQ+PGtleXdvcmQ+KnRy

YW5zY2F0aGV0ZXIgbWl0cmFsIHZhbHZlIHJlcGxhY2VtZW50PC9rZXl3b3JkPjwva2V5d29yZHM+

PGRhdGVzPjx5ZWFyPjIwMTg8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5KYW4gMjwvZGF0ZT48L3B1

Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE1NTgtMzU5NyAoRWxlY3Ryb25pYykmI3hEOzA3MzUtMTA5

NyAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MjkxMDI2ODk8L2FjY2Vzc2lvbi1udW0+

PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHBzOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVi

bWVkLzI5MTAyNjg5PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291

cmNlLW51bT4xMC4xMDE2L2ouamFjYy4yMDE3LjEwLjA2MTwvZWxlY3Ryb25pYy1yZXNvdXJjZS1u

dW0+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT5=

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CYXBhdDwvQXV0aG9yPjxZZWFyPjIwMTg8L1llYXI+PFJl

Y051bT40NzE8L1JlY051bT48RGlzcGxheVRleHQ+KDExKTwvRGlzcGxheVRleHQ+PHJlY29yZD48

cmVjLW51bWJlcj40NzE8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRi

LWlkPSI5d2VlcjV4MHFkc3QwNWV0ZjIxNXR4cjV6YXN2dHJ0dHMwejUiIHRpbWVzdGFtcD0iMTU4

MDQ2OTEzMyI+NDcxPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwg

QXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5CYXBh

dCwgVi48L2F1dGhvcj48YXV0aG9yPlJhamFnb3BhbCwgVi48L2F1dGhvcj48YXV0aG9yPk1lZHVy

aSwgQy48L2F1dGhvcj48YXV0aG9yPkZhcml2YXIsIFIuIFMuPC9hdXRob3I+PGF1dGhvcj5XYWx0

b24sIEEuPC9hdXRob3I+PGF1dGhvcj5EdWZmeSwgUy4gSi48L2F1dGhvcj48YXV0aG9yPkdvb2xl

eSwgUi48L2F1dGhvcj48YXV0aG9yPkFsbWVpZGEsIEEuPC9hdXRob3I+PGF1dGhvcj5SZWFyZG9u

LCBNLiBKLjwvYXV0aG9yPjxhdXRob3I+S2xlaW1hbiwgTi4gUy48L2F1dGhvcj48YXV0aG9yPlNw

YXJnaWFzLCBLLjwvYXV0aG9yPjxhdXRob3I+UGF0dGFrb3MsIFMuPC9hdXRob3I+PGF1dGhvcj5O

ZywgTS4gSy48L2F1dGhvcj48YXV0aG9yPldpbHNvbiwgTS48L2F1dGhvcj48YXV0aG9yPkFkYW1z

LCBELiBILjwvYXV0aG9yPjxhdXRob3I+TGVvbiwgTS48L2F1dGhvcj48YXV0aG9yPk1hY2ssIE0u

IEouPC9hdXRob3I+PGF1dGhvcj5DaGVub3dldGgsIFMuPC9hdXRob3I+PGF1dGhvcj5Tb3Jhamph

LCBQLjwvYXV0aG9yPjxhdXRob3I+SW50cmVwaWQgR2xvYmFsIFBpbG90IFN0dWR5LCBJbnZlc3Rp

Z2F0b3JzPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+U3Qu

IFRob21hcyZhcG9zOyBIb3NwaXRhbCwgTG9uZG9uLCBVbml0ZWQgS2luZ2RvbTsgTmV3IFlvcmsg

UHJlc2J5dGVyaWFuL0NvbHVtYmlhIFVuaXZlcnNpdHkgTWVkaWNhbCBDZW50ZXIsIE5ldyBZb3Jr

LCBOZXcgWW9yay4mI3hEO1BpZWRtb250IEhlYXJ0IEluc3RpdHV0ZSwgQXRsYW50YSwgR2Vvcmdp

YS4mI3hEO0FiYm90dCBOb3J0aHdlc3Rlcm4gSG9zcGl0YWwsIE1pbm5lYXBvbGlzLCBNaW5uZXNv

dGEuJiN4RDtDYXJkaW9sb2d5IERlcGFydG1lbnQsIFRoZSBBbGZyZWQsIE1lbGJvdXJuZSwgQXVz

dHJhbGlhLiYjeEQ7TW9uYXNoIEhlYXJ0LCBNZWxib3VybmUsIEF1c3RyYWxpYS4mI3hEO0hvdXN0

b24gTWV0aG9kaXN0IERlQmFrZXkgSGVhcnQgYW5kIFZhc2N1bGFyIENlbnRlciwgVGhlIE1ldGhv

ZGlzdCBIb3NwaXRhbCwgSG91c3RvbiwgVGV4YXMuJiN4RDtIeWdlaWEgSG9zcGl0YWwsIEF0aGVu

cywgR3JlZWNlLiYjeEQ7Um95YWwgUHJpbmNlIEFsZnJlZCBIb3NwaXRhbCwgU3lkbmV5LCBBdXN0

cmFsaWEuJiN4RDtNb3VudCBTaW5haSBNZWRpY2FsIENlbnRlciwgTmV3IFlvcmssIE5ldyBZb3Jr

LiYjeEQ7TmV3IFlvcmsgUHJlc2J5dGVyaWFuL0NvbHVtYmlhIFVuaXZlcnNpdHkgTWVkaWNhbCBD

ZW50ZXIsIE5ldyBZb3JrLCBOZXcgWW9yay4mI3hEO0JheWxvciBTY290dCAmYW1wOyBXaGl0ZSBI

ZWFsdGgsIFBsYW5vLCBUZXhhcy4mI3hEO01lZHRyb25pYywgTWlubmVhcG9saXMsIE1pbm5lc290

YS4mI3hEO0FiYm90dCBOb3J0aHdlc3Rlcm4gSG9zcGl0YWwsIE1pbm5lYXBvbGlzLCBNaW5uZXNv

dGEuIEVsZWN0cm9uaWMgYWRkcmVzczogcGF1bC5zb3JhamphQGFsbGluYS5jb20uPC9hdXRoLWFk

ZHJlc3M+PHRpdGxlcz48dGl0bGU+RWFybHkgRXhwZXJpZW5jZSBXaXRoIE5ldyBUcmFuc2NhdGhl

dGVyIE1pdHJhbCBWYWx2ZSBSZXBsYWNlbWVudDwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5KIEFt

IENvbGwgQ2FyZGlvbDwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxs

LXRpdGxlPkogQW0gQ29sbCBDYXJkaW9sPC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48cGFnZXM+

MTItMjE8L3BhZ2VzPjx2b2x1bWU+NzE8L3ZvbHVtZT48bnVtYmVyPjE8L251bWJlcj48ZWRpdGlv

bj4yMDE3LzExLzA2PC9lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5BZ2VkPC9rZXl3b3JkPjxr

ZXl3b3JkPkFnZWQsIDgwIGFuZCBvdmVyPC9rZXl3b3JkPjxrZXl3b3JkPkNhcmRpYWMgQ2F0aGV0

ZXJpemF0aW9uL21ldGhvZHM8L2tleXdvcmQ+PGtleXdvcmQ+RWNob2NhcmRpb2dyYXBoeS9tZXRo

b2RzPC9rZXl3b3JkPjxrZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29yZD5IZWFydCBWYWx2

ZSBQcm9zdGhlc2lzLyphZHZlcnNlIGVmZmVjdHM8L2tleXdvcmQ+PGtleXdvcmQ+KkhlYXJ0IFZh

bHZlIFByb3N0aGVzaXMgSW1wbGFudGF0aW9uL2FkdmVyc2UgZWZmZWN0cy9pbnN0cnVtZW50YXRp

b24vbWV0aG9kczwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+TWFs

ZTwva2V5d29yZD48a2V5d29yZD4qTWl0cmFsIFZhbHZlL2RpYWdub3N0aWMgaW1hZ2luZy9zdXJn

ZXJ5PC9rZXl3b3JkPjxrZXl3b3JkPk1pdHJhbCBWYWx2ZSBJbnN1ZmZpY2llbmN5L2RpYWdub3Np

cy9waHlzaW9wYXRob2xvZ3kvKnN1cmdlcnk8L2tleXdvcmQ+PGtleXdvcmQ+T3V0Y29tZSBhbmQg

UHJvY2VzcyBBc3Nlc3NtZW50LCBIZWFsdGggQ2FyZTwva2V5d29yZD48a2V5d29yZD4qUG9zdG9w

ZXJhdGl2ZSBDb21wbGljYXRpb25zL2RpYWdub3Npcy9tb3J0YWxpdHkvcGh5c2lvcGF0aG9sb2d5

PC9rZXl3b3JkPjxrZXl3b3JkPlJpc2sgRmFjdG9yczwva2V5d29yZD48a2V5d29yZD5TZXZlcml0

eSBvZiBJbGxuZXNzIEluZGV4PC9rZXl3b3JkPjxrZXl3b3JkPlRpbWUgRmFjdG9yczwva2V5d29y

ZD48a2V5d29yZD5UcmVhdG1lbnQgT3V0Y29tZTwva2V5d29yZD48a2V5d29yZD5WZW50cmljdWxh

ciBGdW5jdGlvbiwgTGVmdDwva2V5d29yZD48a2V5d29yZD4qbWl0cmFsIHZhbHZlIHJlZ3VyZ2l0

YXRpb248L2tleXdvcmQ+PGtleXdvcmQ+KnByb3N0aGVzaXM8L2tleXdvcmQ+PGtleXdvcmQ+KnRy

YW5zY2F0aGV0ZXIgbWl0cmFsIHZhbHZlIHJlcGxhY2VtZW50PC9rZXl3b3JkPjwva2V5d29yZHM+

PGRhdGVzPjx5ZWFyPjIwMTg8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5KYW4gMjwvZGF0ZT48L3B1

Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE1NTgtMzU5NyAoRWxlY3Ryb25pYykmI3hEOzA3MzUtMTA5

NyAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MjkxMDI2ODk8L2FjY2Vzc2lvbi1udW0+

PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHBzOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVi

bWVkLzI5MTAyNjg5PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291

cmNlLW51bT4xMC4xMDE2L2ouamFjYy4yMDE3LjEwLjA2MTwvZWxlY3Ryb25pYy1yZXNvdXJjZS1u

dW0+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT5=

ADDIN EN.CITE.DATA (11)InvestigationalSapien M3Edwards Lifescienes, Irvince, CA, USANitinol docking system, size 29 valve with knitted PET skirtTrans-septal, transapical ADDIN EN.CITE <EndNote><Cite><Author>Webb</Author><Year>2019</Year><RecNum>472</RecNum><DisplayText>(12)</DisplayText><record><rec-number>472</rec-number><foreign-keys><key app="EN" db-id="9weer5x0qdst05etf215txr5zasvtrtts0z5" timestamp="1580469180">472</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Webb, J. G.</author><author>Murdoch, D. J.</author><author>Boone, R. H.</author><author>Moss, R.</author><author>Attinger-Toller, A.</author><author>Blanke, P.</author><author>Cheung, A.</author><author>Hensey, M.</author><author>Leipsic, J.</author><author>Ong, K.</author><author>Sathananthan, J.</author><author>Wood, D. A.</author><author>Ye, J.</author><author>Tartara, P.</author></authors></contributors><auth-address>Centre for Heart Valve Innovation, St Paul&apos;s Hospital, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address: johngraydonwebb@.&#xD;Centre for Heart Valve Innovation, St Paul&apos;s Hospital, University of British Columbia, Vancouver, British Columbia, Canada.</auth-address><titles><title>Percutaneous Transcatheter Mitral Valve Replacement: First-in-Human Experience With a New Transseptal System</title><secondary-title>J Am Coll Cardiol</secondary-title></titles><periodical><full-title>J Am Coll Cardiol</full-title></periodical><pages>1239-1246</pages><volume>73</volume><number>11</number><edition>2019/03/23</edition><keywords><keyword>mitral valve</keyword><keyword>transcatheter</keyword></keywords><dates><year>2019</year><pub-dates><date>Mar 26</date></pub-dates></dates><isbn>1558-3597 (Electronic)&#xD;0735-1097 (Linking)</isbn><accession-num>30898198</accession-num><urls><related-urls><url>;(12)InvestigationalTiaraNeovasc Inc., Richmond, BC, CanadaStented bioprosthesis with 3-point anchoring systemTrans-apical ADDIN EN.CITE <EndNote><Cite><Author>Verheye</Author><Year>2015</Year><RecNum>474</RecNum><DisplayText>(13)</DisplayText><record><rec-number>474</rec-number><foreign-keys><key app="EN" db-id="9weer5x0qdst05etf215txr5zasvtrtts0z5" timestamp="1580469210">474</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Verheye, S.</author><author>Cheung, A.</author><author>Leon, M.</author><author>Banai, S.</author></authors></contributors><auth-address>Antwerp Cardiovascular Center, ZNA Middelheim, Antwerp, Belgium.</auth-address><titles><title>The Tiara transcatheter mitral valve implantation system</title><secondary-title>EuroIntervention</secondary-title></titles><periodical><full-title>EuroIntervention</full-title></periodical><pages>W71-2</pages><volume>11 Suppl W</volume><edition>2015/09/19</edition><keywords><keyword>*Bioprosthesis</keyword><keyword>Cardiac Catheterization/adverse effects/*instrumentation/methods</keyword><keyword>*Cardiac Catheters</keyword><keyword>*Heart Valve Prosthesis</keyword><keyword>Heart Valve Prosthesis Implantation/adverse effects/*instrumentation/methods</keyword><keyword>Hemodynamics</keyword><keyword>Humans</keyword><keyword>*Mitral Valve/physiopathology</keyword><keyword>Mitral Valve Insufficiency/diagnosis/physiopathology/*therapy</keyword><keyword>Patient Selection</keyword><keyword>Prosthesis Design</keyword><keyword>Risk Factors</keyword><keyword>Treatment Outcome</keyword></keywords><dates><year>2015</year><pub-dates><date>Sep</date></pub-dates></dates><isbn>1969-6213 (Electronic)&#xD;1774-024X (Linking)</isbn><accession-num>26384197</accession-num><urls><related-urls><url>;(13)InvestigationalHigh LifeHighLife SAS, Paris, FranceDual structure design: Stented bioprosthesis and stabilizing sub annular implant (SAI)Trans-atrial and trans-apicalPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CYXJiYW50aTwvQXV0aG9yPjxZZWFyPjIwMTc8L1llYXI+

PFJlY051bT40NzY8L1JlY051bT48RGlzcGxheVRleHQ+KDE0KTwvRGlzcGxheVRleHQ+PHJlY29y

ZD48cmVjLW51bWJlcj40NzY8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4i

IGRiLWlkPSI5d2VlcjV4MHFkc3QwNWV0ZjIxNXR4cjV6YXN2dHJ0dHMwejUiIHRpbWVzdGFtcD0i

MTU4MDQ2OTQ1OCI+NDc2PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJu

YWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5C

YXJiYW50aSwgTS48L2F1dGhvcj48YXV0aG9yPlBpYXp6YSwgTi48L2F1dGhvcj48YXV0aG9yPk1h

bmdpYWZpY28sIFMuPC9hdXRob3I+PGF1dGhvcj5CdWl0aGlldSwgSi48L2F1dGhvcj48YXV0aG9y

PkJsZWl6aWZmZXIsIFMuPC9hdXRob3I+PGF1dGhvcj5Sb25zaXZhbGxlLCBHLjwvYXV0aG9yPjxh

dXRob3I+U2NhbmR1cmEsIFMuPC9hdXRob3I+PGF1dGhvcj5HaXVmZnJpZGEsIEEuPC9hdXRob3I+

PGF1dGhvcj5Qb3BvbG8gUnViYmlvLCBBLjwvYXV0aG9yPjxhdXRob3I+TWF6emFtdXRvLCBNLjwv

YXV0aG9yPjxhdXRob3I+U2dyb2ksIEMuPC9hdXRob3I+PGF1dGhvcj5MYW5nZSwgUi48L2F1dGhv

cj48YXV0aG9yPlRhbWJ1cmlubywgQy48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+

PGF1dGgtYWRkcmVzcz5GZXJyYXJvdHRvIEhvc3BpdGFsLCBVbml2ZXJzaXR5IG9mIENhdGFuaWEs

IENhdGFuaWEsIEl0YWx5LiBFbGVjdHJvbmljIGFkZHJlc3M6IG1iYXJiYW50aTgzQGdtYWlsLmNv

bS4mI3hEO01jR2lsbCBVbml2ZXJzaXR5IEhlYWx0aCBDZW50ZXIsIE1vbnRyZWFsLCBRdWViZWMs

IENhbmFkYS4mI3hEO0ZlcnJhcm90dG8gSG9zcGl0YWwsIFVuaXZlcnNpdHkgb2YgQ2F0YW5pYSwg

Q2F0YW5pYSwgSXRhbHkuJiN4RDtHZXJtYW4gSGVhcnQgQ2VudGVyIE11bmljaCwgVGVjaG5pY2Fs

IFVuaXZlcnNpdHkgTXVuaWNoLCBNdW5pY2gsIEdlcm1hbnkuPC9hdXRoLWFkZHJlc3M+PHRpdGxl

cz48dGl0bGU+VHJhbnNjYXRoZXRlciBNaXRyYWwgVmFsdmUgSW1wbGFudGF0aW9uIFVzaW5nIHRo

ZSBIaWdoTGlmZSBTeXN0ZW08L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+SkFDQyBDYXJkaW92YXNj

IEludGVydjwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxl

PkpBQ0MgQ2FyZGlvdmFzYyBJbnRlcnY8L2Z1bGwtdGl0bGU+PC9wZXJpb2RpY2FsPjxwYWdlcz4x

NjYyLTE2NzA8L3BhZ2VzPjx2b2x1bWU+MTA8L3ZvbHVtZT48bnVtYmVyPjE2PC9udW1iZXI+PGVk

aXRpb24+MjAxNy8wOC8yNjwvZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QWdlZDwva2V5d29y

ZD48a2V5d29yZD5DYXJkaWFjIENhdGhldGVyaXphdGlvbi9hZHZlcnNlIGVmZmVjdHMvKmluc3Ry

dW1lbnRhdGlvbi9tZXRob2RzPC9rZXl3b3JkPjxrZXl3b3JkPkVjaG9jYXJkaW9ncmFwaHksIFRo

cmVlLURpbWVuc2lvbmFsPC9rZXl3b3JkPjxrZXl3b3JkPkVjaG9jYXJkaW9ncmFwaHksIFRyYW5z

ZXNvcGhhZ2VhbDwva2V5d29yZD48a2V5d29yZD5GYXRhbCBPdXRjb21lPC9rZXl3b3JkPjxrZXl3

b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29yZD4qSGVhcnQgVmFsdmUgUHJvc3RoZXNpczwva2V5

d29yZD48a2V5d29yZD5IZWFydCBWYWx2ZSBQcm9zdGhlc2lzIEltcGxhbnRhdGlvbi9hZHZlcnNl

IGVmZmVjdHMvKmluc3RydW1lbnRhdGlvbi9tZXRob2RzPC9rZXl3b3JkPjxrZXl3b3JkPkhlbW9k

eW5hbWljczwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwv

a2V5d29yZD48a2V5d29yZD5NaXRyYWwgVmFsdmUvZGlhZ25vc3RpYyBpbWFnaW5nL3BoeXNpb3Bh

dGhvbG9neS8qc3VyZ2VyeTwva2V5d29yZD48a2V5d29yZD5NaXRyYWwgVmFsdmUgSW5zdWZmaWNp

ZW5jeS9kaWFnbm9zdGljIGltYWdpbmcvcGh5c2lvcGF0aG9sb2d5LypzdXJnZXJ5PC9rZXl3b3Jk

PjxrZXl3b3JkPk11bHRpZGV0ZWN0b3IgQ29tcHV0ZWQgVG9tb2dyYXBoeTwva2V5d29yZD48a2V5

d29yZD5Qcm9zdGhlc2lzIERlc2lnbjwva2V5d29yZD48a2V5d29yZD5SZWNvdmVyeSBvZiBGdW5j

dGlvbjwva2V5d29yZD48a2V5d29yZD5TdHJva2UgVm9sdW1lPC9rZXl3b3JkPjxrZXl3b3JkPlRp

bWUgRmFjdG9yczwva2V5d29yZD48a2V5d29yZD5UcmVhdG1lbnQgT3V0Y29tZTwva2V5d29yZD48

a2V5d29yZD5WZW50cmljdWxhciBGdW5jdGlvbiwgTGVmdDwva2V5d29yZD48a2V5d29yZD4qbWl0

cmFsIHJlZ3VyZ2l0YXRpb248L2tleXdvcmQ+PGtleXdvcmQ+KnByb3N0aGVzaXM8L2tleXdvcmQ+

PGtleXdvcmQ+KnRyYW5zY2F0aGV0ZXIgbWl0cmFsIHZhbHZlIHJlcGxhY2VtZW50PC9rZXl3b3Jk

Pjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTc8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5BdWcg

Mjg8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xODc2LTc2MDUgKEVsZWN0cm9uaWMp

JiN4RDsxOTM2LTg3OTggKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjI4ODM4NDc3PC9h

Y2Nlc3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwczovL3d3dy5uY2JpLm5s

bS5uaWguZ292L3B1Ym1lZC8yODgzODQ3NzwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxl

Y3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTAxNi9qLmpjaW4uMjAxNy4wNi4wNDY8L2VsZWN0cm9u

aWMtcmVzb3VyY2UtbnVtPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+AG==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CYXJiYW50aTwvQXV0aG9yPjxZZWFyPjIwMTc8L1llYXI+

PFJlY051bT40NzY8L1JlY051bT48RGlzcGxheVRleHQ+KDE0KTwvRGlzcGxheVRleHQ+PHJlY29y

ZD48cmVjLW51bWJlcj40NzY8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4i

IGRiLWlkPSI5d2VlcjV4MHFkc3QwNWV0ZjIxNXR4cjV6YXN2dHJ0dHMwejUiIHRpbWVzdGFtcD0i

MTU4MDQ2OTQ1OCI+NDc2PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJu

YWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5C

YXJiYW50aSwgTS48L2F1dGhvcj48YXV0aG9yPlBpYXp6YSwgTi48L2F1dGhvcj48YXV0aG9yPk1h

bmdpYWZpY28sIFMuPC9hdXRob3I+PGF1dGhvcj5CdWl0aGlldSwgSi48L2F1dGhvcj48YXV0aG9y

PkJsZWl6aWZmZXIsIFMuPC9hdXRob3I+PGF1dGhvcj5Sb25zaXZhbGxlLCBHLjwvYXV0aG9yPjxh

dXRob3I+U2NhbmR1cmEsIFMuPC9hdXRob3I+PGF1dGhvcj5HaXVmZnJpZGEsIEEuPC9hdXRob3I+

PGF1dGhvcj5Qb3BvbG8gUnViYmlvLCBBLjwvYXV0aG9yPjxhdXRob3I+TWF6emFtdXRvLCBNLjwv

YXV0aG9yPjxhdXRob3I+U2dyb2ksIEMuPC9hdXRob3I+PGF1dGhvcj5MYW5nZSwgUi48L2F1dGhv

cj48YXV0aG9yPlRhbWJ1cmlubywgQy48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+

PGF1dGgtYWRkcmVzcz5GZXJyYXJvdHRvIEhvc3BpdGFsLCBVbml2ZXJzaXR5IG9mIENhdGFuaWEs

IENhdGFuaWEsIEl0YWx5LiBFbGVjdHJvbmljIGFkZHJlc3M6IG1iYXJiYW50aTgzQGdtYWlsLmNv

bS4mI3hEO01jR2lsbCBVbml2ZXJzaXR5IEhlYWx0aCBDZW50ZXIsIE1vbnRyZWFsLCBRdWViZWMs

IENhbmFkYS4mI3hEO0ZlcnJhcm90dG8gSG9zcGl0YWwsIFVuaXZlcnNpdHkgb2YgQ2F0YW5pYSwg

Q2F0YW5pYSwgSXRhbHkuJiN4RDtHZXJtYW4gSGVhcnQgQ2VudGVyIE11bmljaCwgVGVjaG5pY2Fs

IFVuaXZlcnNpdHkgTXVuaWNoLCBNdW5pY2gsIEdlcm1hbnkuPC9hdXRoLWFkZHJlc3M+PHRpdGxl

cz48dGl0bGU+VHJhbnNjYXRoZXRlciBNaXRyYWwgVmFsdmUgSW1wbGFudGF0aW9uIFVzaW5nIHRo

ZSBIaWdoTGlmZSBTeXN0ZW08L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+SkFDQyBDYXJkaW92YXNj

IEludGVydjwvc2Vjb25kYXJ5LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxl

PkpBQ0MgQ2FyZGlvdmFzYyBJbnRlcnY8L2Z1bGwtdGl0bGU+PC9wZXJpb2RpY2FsPjxwYWdlcz4x

NjYyLTE2NzA8L3BhZ2VzPjx2b2x1bWU+MTA8L3ZvbHVtZT48bnVtYmVyPjE2PC9udW1iZXI+PGVk

aXRpb24+MjAxNy8wOC8yNjwvZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QWdlZDwva2V5d29y

ZD48a2V5d29yZD5DYXJkaWFjIENhdGhldGVyaXphdGlvbi9hZHZlcnNlIGVmZmVjdHMvKmluc3Ry

dW1lbnRhdGlvbi9tZXRob2RzPC9rZXl3b3JkPjxrZXl3b3JkPkVjaG9jYXJkaW9ncmFwaHksIFRo

cmVlLURpbWVuc2lvbmFsPC9rZXl3b3JkPjxrZXl3b3JkPkVjaG9jYXJkaW9ncmFwaHksIFRyYW5z

ZXNvcGhhZ2VhbDwva2V5d29yZD48a2V5d29yZD5GYXRhbCBPdXRjb21lPC9rZXl3b3JkPjxrZXl3

b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29yZD4qSGVhcnQgVmFsdmUgUHJvc3RoZXNpczwva2V5

d29yZD48a2V5d29yZD5IZWFydCBWYWx2ZSBQcm9zdGhlc2lzIEltcGxhbnRhdGlvbi9hZHZlcnNl

IGVmZmVjdHMvKmluc3RydW1lbnRhdGlvbi9tZXRob2RzPC9rZXl3b3JkPjxrZXl3b3JkPkhlbW9k

eW5hbWljczwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwv

a2V5d29yZD48a2V5d29yZD5NaXRyYWwgVmFsdmUvZGlhZ25vc3RpYyBpbWFnaW5nL3BoeXNpb3Bh

dGhvbG9neS8qc3VyZ2VyeTwva2V5d29yZD48a2V5d29yZD5NaXRyYWwgVmFsdmUgSW5zdWZmaWNp

ZW5jeS9kaWFnbm9zdGljIGltYWdpbmcvcGh5c2lvcGF0aG9sb2d5LypzdXJnZXJ5PC9rZXl3b3Jk

PjxrZXl3b3JkPk11bHRpZGV0ZWN0b3IgQ29tcHV0ZWQgVG9tb2dyYXBoeTwva2V5d29yZD48a2V5

d29yZD5Qcm9zdGhlc2lzIERlc2lnbjwva2V5d29yZD48a2V5d29yZD5SZWNvdmVyeSBvZiBGdW5j

dGlvbjwva2V5d29yZD48a2V5d29yZD5TdHJva2UgVm9sdW1lPC9rZXl3b3JkPjxrZXl3b3JkPlRp

bWUgRmFjdG9yczwva2V5d29yZD48a2V5d29yZD5UcmVhdG1lbnQgT3V0Y29tZTwva2V5d29yZD48

a2V5d29yZD5WZW50cmljdWxhciBGdW5jdGlvbiwgTGVmdDwva2V5d29yZD48a2V5d29yZD4qbWl0

cmFsIHJlZ3VyZ2l0YXRpb248L2tleXdvcmQ+PGtleXdvcmQ+KnByb3N0aGVzaXM8L2tleXdvcmQ+

PGtleXdvcmQ+KnRyYW5zY2F0aGV0ZXIgbWl0cmFsIHZhbHZlIHJlcGxhY2VtZW50PC9rZXl3b3Jk

Pjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTc8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5BdWcg

Mjg8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xODc2LTc2MDUgKEVsZWN0cm9uaWMp

JiN4RDsxOTM2LTg3OTggKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjI4ODM4NDc3PC9h

Y2Nlc3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwczovL3d3dy5uY2JpLm5s

bS5uaWguZ292L3B1Ym1lZC8yODgzODQ3NzwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48ZWxl

Y3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTAxNi9qLmpjaW4uMjAxNy4wNi4wNDY8L2VsZWN0cm9u

aWMtcmVzb3VyY2UtbnVtPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+AG==

ADDIN EN.CITE.DATA (14)InvestigationalFDA Food and Drug Administration; CE Conformité EuropéenneSuppl. Table 2.Tricuspid Valve DevicesTranscatheter Mitral Valve RepairDevice/ManufacturerMechanism of actionAccessStudyApprovalTriCinch, 4TECH Cardio Ireland Ltd., Galway, IrelandAnnuloplasty via epicardial coil anchored to IVC stent Trans-femoral veinPREVENTNCT02098200InvestigationalMIA, MicroInterventonal Devices, Inc., Newton, PA, USAPlication mediated annuloplasty using proprietary anchoring systemTrans-femoral, surgicalSTTAR InvestigationalPASTA, LSI Solutions, New York, New York, USAPledgeted sutures to reduce tricuspid orificeTrans-jugular, transapicalPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LaGFuPC9BdXRob3I+PFllYXI+MjAxODwvWWVhcj48UmVj

TnVtPjQ4ODwvUmVjTnVtPjxEaXNwbGF5VGV4dD4oMTUpPC9EaXNwbGF5VGV4dD48cmVjb3JkPjxy

ZWMtbnVtYmVyPjQ4ODwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGIt

aWQ9Ijl3ZWVyNXgwcWRzdDA1ZXRmMjE1dHhyNXphc3Z0cnR0czB6NSIgdGltZXN0YW1wPSIxNTgw

NDcwMDU3Ij40ODg8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBB

cnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPktoYW4s

IEouIE0uPC9hdXRob3I+PGF1dGhvcj5Sb2dlcnMsIFQuPC9hdXRob3I+PGF1dGhvcj5TY2hlbmtl

LCBXLiBILjwvYXV0aG9yPjxhdXRob3I+R3JlZW5iYXVtLCBBLiBCLjwvYXV0aG9yPjxhdXRob3I+

QmFiYWxpYXJvcywgVi4gQy48L2F1dGhvcj48YXV0aG9yPlBhb25lLCBHLjwvYXV0aG9yPjxhdXRo

b3I+UmFtYXNhd215LCBSLjwvYXV0aG9yPjxhdXRob3I+Q2hlbiwgTS4gWS48L2F1dGhvcj48YXV0

aG9yPkhlcnprYSwgRC4gQS48L2F1dGhvcj48YXV0aG9yPkxlZGVybWFuLCBSLiBKLjwvYXV0aG9y

PjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkNhcmRpb3Zhc2N1bGFyIEJy

YW5jaCwgRGl2aXNpb24gb2YgSW50cmFtdXJhbCBSZXNlYXJjaCwgTmF0aW9uYWwgSGVhcnQgTHVu

ZyBhbmQgQmxvb2QgSW5zdGl0dXRlLCBOYXRpb25hbCBJbnN0aXR1dGVzIG9mIEhlYWx0aCwgQmV0

aGVzZGEsIE1hcnlsYW5kLiYjeEQ7Q2VudGVyIGZvciBTdHJ1Y3R1cmFsIEhlYXJ0IERpc2Vhc2Us

IERpdmlzaW9uIG9mIENhcmRpb2xvZ3ksIEhlbnJ5IEZvcmQgSGVhbHRoIFN5c3RlbSwgRGV0cm9p

dCwgTWljaGlnYW4uJiN4RDtTdHJ1Y3R1cmFsIEhlYXJ0IGFuZCBWYWx2ZSBDZW50ZXIsIEVtb3J5

IFVuaXZlcnNpdHkgSG9zcGl0YWwsIEF0bGFudGEsIEdlb3JnaWEuJiN4RDtEaXZpc2lvbiBvZiBD

YXJkaWFjIFN1cmdlcnksIEhlbnJ5IEZvcmQgSGVhbHRoIFN5c3RlbSwgRGV0cm9pdCwgTWljaGln

YW4uPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+VHJhbnNjYXRoZXRlciBwbGVkZ2V0LWFz

c2lzdGVkIHN1dHVyZSB0cmljdXNwaWQgYW5udWxvcGxhc3R5IChQQVNUQSkgdG8gY3JlYXRlIGEg

ZG91YmxlLW9yaWZpY2UgdmFsdmU8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+Q2F0aGV0ZXIgQ2Fy

ZGlvdmFzYyBJbnRlcnY8L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVs

bC10aXRsZT5DYXRoZXRlciBDYXJkaW92YXNjIEludGVydjwvZnVsbC10aXRsZT48L3BlcmlvZGlj

YWw+PHBhZ2VzPkUxNzUtRTE4NDwvcGFnZXM+PHZvbHVtZT45Mjwvdm9sdW1lPjxudW1iZXI+Mzwv

bnVtYmVyPjxlZGl0aW9uPjIwMTgvMDIvMDc8L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFu

aW1hbHM8L2tleXdvcmQ+PGtleXdvcmQ+KkNhcmRpYWMgQ2F0aGV0ZXJpemF0aW9uL2FkdmVyc2Ug

ZWZmZWN0czwva2V5d29yZD48a2V5d29yZD5DYXJkaWFjIFZhbHZlIEFubnVsb3BsYXN0eS9hZHZl

cnNlIGVmZmVjdHMvKm1ldGhvZHM8L2tleXdvcmQ+PGtleXdvcmQ+RGlzZWFzZSBNb2RlbHMsIEFu

aW1hbDwva2V5d29yZD48a2V5d29yZD5FY2hvY2FyZGlvZ3JhcGh5LCBEb3BwbGVyLCBDb2xvcjwv

a2V5d29yZD48a2V5d29yZD4qSGVtb2R5bmFtaWNzPC9rZXl3b3JkPjxrZXl3b3JkPk1hZ25ldGlj

IFJlc29uYW5jZSBJbWFnaW5nPC9rZXl3b3JkPjxrZXl3b3JkPlJlY292ZXJ5IG9mIEZ1bmN0aW9u

PC9rZXl3b3JkPjxrZXl3b3JkPlN1cyBzY3JvZmE8L2tleXdvcmQ+PGtleXdvcmQ+KlN1dHVyZSBU

ZWNobmlxdWVzL2FkdmVyc2UgZWZmZWN0czwva2V5d29yZD48a2V5d29yZD5UaW1lIEZhY3RvcnM8

L2tleXdvcmQ+PGtleXdvcmQ+VHJpY3VzcGlkIFZhbHZlL2RpYWdub3N0aWMgaW1hZ2luZy9wYXRo

b2xvZ3kvcGh5c2lvcGF0aG9sb2d5LypzdXJnZXJ5PC9rZXl3b3JkPjxrZXl3b3JkPlRyaWN1c3Bp

ZCBWYWx2ZSBJbnN1ZmZpY2llbmN5L2RpYWdub3N0aWM8L2tleXdvcmQ+PGtleXdvcmQ+aW1hZ2lu

Zy9wYXRob2xvZ3kvcGh5c2lvcGF0aG9sb2d5LypzdXJnZXJ5PC9rZXl3b3JkPjxrZXl3b3JkPipz

dHJ1Y3R1cmFsIGhlYXJ0IGRpc2Vhc2U8L2tleXdvcmQ+PGtleXdvcmQ+KnRyYW5zY2F0aGV0ZXIg

ZWxlY3Ryb3N1cmdlcnk8L2tleXdvcmQ+PGtleXdvcmQ+KnRyaWN1c3BpZCBhbm51bG9wbGFzdHk8

L2tleXdvcmQ+PGtleXdvcmQ+KnRyaWN1c3BpZCB2YWx2ZSByZWd1cmdpdGF0aW9uPC9rZXl3b3Jk

Pjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTg8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5TZXAg

MTwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE1MjItNzI2WCAoRWxlY3Ryb25pYykm

I3hEOzE1MjItMTk0NiAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+Mjk0MDU1NjQ8L2Fj

Y2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHBzOi8vd3d3Lm5jYmkubmxt

Lm5paC5nb3YvcHVibWVkLzI5NDA1NTY0PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxjdXN0

b20yPlBNQzYwNzg4MzU8L2N1c3RvbTI+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEwMDIv

Y2NkLjI3NTMxPC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PC9FbmRO

b3RlPn==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LaGFuPC9BdXRob3I+PFllYXI+MjAxODwvWWVhcj48UmVj

TnVtPjQ4ODwvUmVjTnVtPjxEaXNwbGF5VGV4dD4oMTUpPC9EaXNwbGF5VGV4dD48cmVjb3JkPjxy

ZWMtbnVtYmVyPjQ4ODwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGIt

aWQ9Ijl3ZWVyNXgwcWRzdDA1ZXRmMjE1dHhyNXphc3Z0cnR0czB6NSIgdGltZXN0YW1wPSIxNTgw

NDcwMDU3Ij40ODg8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBB

cnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPktoYW4s

IEouIE0uPC9hdXRob3I+PGF1dGhvcj5Sb2dlcnMsIFQuPC9hdXRob3I+PGF1dGhvcj5TY2hlbmtl

LCBXLiBILjwvYXV0aG9yPjxhdXRob3I+R3JlZW5iYXVtLCBBLiBCLjwvYXV0aG9yPjxhdXRob3I+

QmFiYWxpYXJvcywgVi4gQy48L2F1dGhvcj48YXV0aG9yPlBhb25lLCBHLjwvYXV0aG9yPjxhdXRo

b3I+UmFtYXNhd215LCBSLjwvYXV0aG9yPjxhdXRob3I+Q2hlbiwgTS4gWS48L2F1dGhvcj48YXV0

aG9yPkhlcnprYSwgRC4gQS48L2F1dGhvcj48YXV0aG9yPkxlZGVybWFuLCBSLiBKLjwvYXV0aG9y

PjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9ycz48YXV0aC1hZGRyZXNzPkNhcmRpb3Zhc2N1bGFyIEJy

YW5jaCwgRGl2aXNpb24gb2YgSW50cmFtdXJhbCBSZXNlYXJjaCwgTmF0aW9uYWwgSGVhcnQgTHVu

ZyBhbmQgQmxvb2QgSW5zdGl0dXRlLCBOYXRpb25hbCBJbnN0aXR1dGVzIG9mIEhlYWx0aCwgQmV0

aGVzZGEsIE1hcnlsYW5kLiYjeEQ7Q2VudGVyIGZvciBTdHJ1Y3R1cmFsIEhlYXJ0IERpc2Vhc2Us

IERpdmlzaW9uIG9mIENhcmRpb2xvZ3ksIEhlbnJ5IEZvcmQgSGVhbHRoIFN5c3RlbSwgRGV0cm9p

dCwgTWljaGlnYW4uJiN4RDtTdHJ1Y3R1cmFsIEhlYXJ0IGFuZCBWYWx2ZSBDZW50ZXIsIEVtb3J5

IFVuaXZlcnNpdHkgSG9zcGl0YWwsIEF0bGFudGEsIEdlb3JnaWEuJiN4RDtEaXZpc2lvbiBvZiBD

YXJkaWFjIFN1cmdlcnksIEhlbnJ5IEZvcmQgSGVhbHRoIFN5c3RlbSwgRGV0cm9pdCwgTWljaGln

YW4uPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+VHJhbnNjYXRoZXRlciBwbGVkZ2V0LWFz

c2lzdGVkIHN1dHVyZSB0cmljdXNwaWQgYW5udWxvcGxhc3R5IChQQVNUQSkgdG8gY3JlYXRlIGEg

ZG91YmxlLW9yaWZpY2UgdmFsdmU8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+Q2F0aGV0ZXIgQ2Fy

ZGlvdmFzYyBJbnRlcnY8L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVs

bC10aXRsZT5DYXRoZXRlciBDYXJkaW92YXNjIEludGVydjwvZnVsbC10aXRsZT48L3BlcmlvZGlj

YWw+PHBhZ2VzPkUxNzUtRTE4NDwvcGFnZXM+PHZvbHVtZT45Mjwvdm9sdW1lPjxudW1iZXI+Mzwv

bnVtYmVyPjxlZGl0aW9uPjIwMTgvMDIvMDc8L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkFu

aW1hbHM8L2tleXdvcmQ+PGtleXdvcmQ+KkNhcmRpYWMgQ2F0aGV0ZXJpemF0aW9uL2FkdmVyc2Ug

ZWZmZWN0czwva2V5d29yZD48a2V5d29yZD5DYXJkaWFjIFZhbHZlIEFubnVsb3BsYXN0eS9hZHZl

cnNlIGVmZmVjdHMvKm1ldGhvZHM8L2tleXdvcmQ+PGtleXdvcmQ+RGlzZWFzZSBNb2RlbHMsIEFu

aW1hbDwva2V5d29yZD48a2V5d29yZD5FY2hvY2FyZGlvZ3JhcGh5LCBEb3BwbGVyLCBDb2xvcjwv

a2V5d29yZD48a2V5d29yZD4qSGVtb2R5bmFtaWNzPC9rZXl3b3JkPjxrZXl3b3JkPk1hZ25ldGlj

IFJlc29uYW5jZSBJbWFnaW5nPC9rZXl3b3JkPjxrZXl3b3JkPlJlY292ZXJ5IG9mIEZ1bmN0aW9u

PC9rZXl3b3JkPjxrZXl3b3JkPlN1cyBzY3JvZmE8L2tleXdvcmQ+PGtleXdvcmQ+KlN1dHVyZSBU

ZWNobmlxdWVzL2FkdmVyc2UgZWZmZWN0czwva2V5d29yZD48a2V5d29yZD5UaW1lIEZhY3RvcnM8

L2tleXdvcmQ+PGtleXdvcmQ+VHJpY3VzcGlkIFZhbHZlL2RpYWdub3N0aWMgaW1hZ2luZy9wYXRo

b2xvZ3kvcGh5c2lvcGF0aG9sb2d5LypzdXJnZXJ5PC9rZXl3b3JkPjxrZXl3b3JkPlRyaWN1c3Bp

ZCBWYWx2ZSBJbnN1ZmZpY2llbmN5L2RpYWdub3N0aWM8L2tleXdvcmQ+PGtleXdvcmQ+aW1hZ2lu

Zy9wYXRob2xvZ3kvcGh5c2lvcGF0aG9sb2d5LypzdXJnZXJ5PC9rZXl3b3JkPjxrZXl3b3JkPipz

dHJ1Y3R1cmFsIGhlYXJ0IGRpc2Vhc2U8L2tleXdvcmQ+PGtleXdvcmQ+KnRyYW5zY2F0aGV0ZXIg

ZWxlY3Ryb3N1cmdlcnk8L2tleXdvcmQ+PGtleXdvcmQ+KnRyaWN1c3BpZCBhbm51bG9wbGFzdHk8

L2tleXdvcmQ+PGtleXdvcmQ+KnRyaWN1c3BpZCB2YWx2ZSByZWd1cmdpdGF0aW9uPC9rZXl3b3Jk

Pjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTg8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5TZXAg

MTwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjE1MjItNzI2WCAoRWxlY3Ryb25pYykm

I3hEOzE1MjItMTk0NiAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+Mjk0MDU1NjQ8L2Fj

Y2Vzc2lvbi1udW0+PHVybHM+PHJlbGF0ZWQtdXJscz48dXJsPmh0dHBzOi8vd3d3Lm5jYmkubmxt

Lm5paC5nb3YvcHVibWVkLzI5NDA1NTY0PC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxjdXN0

b20yPlBNQzYwNzg4MzU8L2N1c3RvbTI+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEwMDIv

Y2NkLjI3NTMxPC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48L3JlY29yZD48L0NpdGU+PC9FbmRO

b3RlPn==

ADDIN EN.CITE.DATA (15)InvestigationalCardioband, Edwards Lifescienes, Irvince, CA, USACircumferential annular reduction using multiple anchors Trans-femoralTRI-REPAIR PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5OaWNrZW5pZzwvQXV0aG9yPjxZZWFyPjIwMTk8L1llYXI+

PFJlY051bT40ODQ8L1JlY051bT48RGlzcGxheVRleHQ+KDE2KTwvRGlzcGxheVRleHQ+PHJlY29y

ZD48cmVjLW51bWJlcj40ODQ8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4i

IGRiLWlkPSI5d2VlcjV4MHFkc3QwNWV0ZjIxNXR4cjV6YXN2dHJ0dHMwejUiIHRpbWVzdGFtcD0i

MTU4MDQ2OTc1NyI+NDg0PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJu

YWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5O

aWNrZW5pZywgRy48L2F1dGhvcj48YXV0aG9yPldlYmVyLCBNLjwvYXV0aG9yPjxhdXRob3I+U2No

dWVsZXIsIFIuPC9hdXRob3I+PGF1dGhvcj5IYXVzbGVpdGVyLCBKLjwvYXV0aG9yPjxhdXRob3I+

TmFiYXVlciwgTS48L2F1dGhvcj48YXV0aG9yPnZvbiBCYXJkZWxlYmVuLCBSLiBTLjwvYXV0aG9y

PjxhdXRob3I+U290aXJpb3UsIEUuPC9hdXRob3I+PGF1dGhvcj5TY2hhZmVyLCBVLjwvYXV0aG9y

PjxhdXRob3I+RGV1c2NobCwgRi48L2F1dGhvcj48YXV0aG9yPkt1Y2ssIEsuIEguPC9hdXRob3I+

PGF1dGhvcj5LcmVpZGVsLCBGLjwvYXV0aG9yPjxhdXRob3I+SnVsaWFyZCwgSi4gTS48L2F1dGhv

cj48YXV0aG9yPkJyb2NoZXQsIEUuPC9hdXRob3I+PGF1dGhvcj5MYXRpYiwgQS48L2F1dGhvcj48

YXV0aG9yPkFncmljb2xhLCBFLjwvYXV0aG9yPjxhdXRob3I+QmFsZHVzLCBTLjwvYXV0aG9yPjxh

dXRob3I+RnJpZWRyaWNocywgSy48L2F1dGhvcj48YXV0aG9yPlZhbmRyYW5naSwgUC48L2F1dGhv

cj48YXV0aG9yPlZlcnRhLCBQLjwvYXV0aG9yPjxhdXRob3I+SGFobiwgUi4gVC48L2F1dGhvcj48

YXV0aG9yPk1haXNhbm8sIEYuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRo

LWFkZHJlc3M+RGVwYXJ0bWVudCBvZiBDYXJkaW9sb2d5LCBVbml2ZXJzaXR5IEhvc3BpdGFsIEJv

bm4sIEJvbm4sIEdlcm1hbnkuIEVsZWN0cm9uaWMgYWRkcmVzczogZ2Vvcmcubmlja2VuaWdAdWti

b25uLmRlLiYjeEQ7RGVwYXJ0bWVudCBvZiBDYXJkaW9sb2d5LCBVbml2ZXJzaXR5IEhvc3BpdGFs

IEJvbm4sIEJvbm4sIEdlcm1hbnkuJiN4RDtMdWR3aWctTWF4aW1pbGlhbnMgVW5pdmVyc2l0eSBI

b3NwaXRhbCBNdW5pY2gsIE11bmljaCwgR2VybWFueS4mI3hEO0RlcGFydG1lbnQgb2YgQ2FyZGlv

bG9neSwgVW5pdmVyc2l0eSBNZWRpY2FsIENlbnRlciBNYWlueiwgTWFpbnosIEdlcm1hbnkuJiN4

RDtTdHJ1Y3R1cmFsIEhlYXJ0IERpdmlzaW9uLCBVbml2ZXJzaXR5IEhlYXJ0IENlbnRlciBIYW1i

dXJnLCBIYW1idXJnLCBHZXJtYW55LiYjeEQ7RGVwYXJ0bWVudCBvZiBDYXJkaW9sb2d5LCBTdC4g

R2VvcmdlIEhvc3BpdGFsLCBIYW1idXJnLCBHZXJtYW55LiYjeEQ7RGVwYXJ0bWVudCBvZiBDYXJk

aW9sb2d5LCBIb3BpdGFsIEJpY2hhdCwgQVAtSFAsIFBhcmlzLCBGcmFuY2U7IERlcGFydGVtZW50

IGRlIENhcmRpb2xvZ2llLCBVbml2ZXJzaXRlIFBhcmlzLURpZGVyb3QsIFBhcmlzLCBGcmFuY2U7

IElOU0VSTSBVLTExNDgsIFBhcmlzLCBGcmFuY2UuJiN4RDtEaXBhcnRpbWVudG8gQ2FyZGlvLVRv

cmFjby1WYXNjb2xhcmUsIFNhbiBSYWZmYWVsZSBJbnN0aXR1dGUsIE1pbGFuLCBJdGFseS4mI3hE

O0hlYXJ0IENlbnRlciwgVW5pdmVyc2l0eSBIb3NwaXRhbCBDb2xvZ25lLCBDb2xvZ25lLCBHZXJt

YW55LiYjeEQ7RWR3YXJkcyBMaWZlc2NpZW5jZXMsIElydmluZSwgQ2FsaWZvcm5pYS4mI3hEO0Nh

cmRpb3Zhc2N1bGFyIFJlc2VhcmNoIEZvdW5kYXRpb24sIE5ldyBZb3JrLCBOZXcgWW9yay4mI3hE

O0RlcGFydG1lbnQgb2YgQ2FyZGlvdmFzY3VsYXIgU3VyZ2VyeSwgVW5pdmVyc2l0eSBIb3NwaXRh

bCBadXJpY2gsIFp1cmljaCwgU3dpdHplcmxhbmQuPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0

bGU+Ni1Nb250aCBPdXRjb21lcyBvZiBUcmljdXNwaWQgVmFsdmUgUmVjb25zdHJ1Y3Rpb24gZm9y

IFBhdGllbnRzIFdpdGggU2V2ZXJlIFRyaWN1c3BpZCBSZWd1cmdpdGF0aW9uPC90aXRsZT48c2Vj

b25kYXJ5LXRpdGxlPkogQW0gQ29sbCBDYXJkaW9sPC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+

PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+SiBBbSBDb2xsIENhcmRpb2w8L2Z1bGwtdGl0bGU+PC9w

ZXJpb2RpY2FsPjxwYWdlcz4xOTA1LTE5MTU8L3BhZ2VzPjx2b2x1bWU+NzM8L3ZvbHVtZT48bnVt

YmVyPjE1PC9udW1iZXI+PGVkaXRpb24+MjAxOS8wNC8yMDwvZWRpdGlvbj48a2V5d29yZHM+PGtl

eXdvcmQ+VHJpLXJlcGFpcjwva2V5d29yZD48a2V5d29yZD5hbm51bGFyIHJlZHVjdGlvbjwva2V5

d29yZD48a2V5d29yZD50cmljdXNwaWQgcmVndXJnaXRhdGlvbjwva2V5d29yZD48a2V5d29yZD50

cmljdXNwaWQgcmVwYWlyPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTk8L3ll

YXI+PHB1Yi1kYXRlcz48ZGF0ZT5BcHIgMjM8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNi

bj4xNTU4LTM1OTcgKEVsZWN0cm9uaWMpJiN4RDswNzM1LTEwOTcgKExpbmtpbmcpPC9pc2JuPjxh

Y2Nlc3Npb24tbnVtPjMwOTk5OTkzPC9hY2Nlc3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+

PHVybD5odHRwczovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8zMDk5OTk5MzwvdXJsPjwv

cmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTAxNi9qLmph

Y2MuMjAxOS4wMS4wNjI8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjwvcmVjb3JkPjwvQ2l0ZT48

L0VuZE5vdGU+AG==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5OaWNrZW5pZzwvQXV0aG9yPjxZZWFyPjIwMTk8L1llYXI+

PFJlY051bT40ODQ8L1JlY051bT48RGlzcGxheVRleHQ+KDE2KTwvRGlzcGxheVRleHQ+PHJlY29y

ZD48cmVjLW51bWJlcj40ODQ8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4i

IGRiLWlkPSI5d2VlcjV4MHFkc3QwNWV0ZjIxNXR4cjV6YXN2dHJ0dHMwejUiIHRpbWVzdGFtcD0i

MTU4MDQ2OTc1NyI+NDg0PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJu

YWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5O

aWNrZW5pZywgRy48L2F1dGhvcj48YXV0aG9yPldlYmVyLCBNLjwvYXV0aG9yPjxhdXRob3I+U2No

dWVsZXIsIFIuPC9hdXRob3I+PGF1dGhvcj5IYXVzbGVpdGVyLCBKLjwvYXV0aG9yPjxhdXRob3I+

TmFiYXVlciwgTS48L2F1dGhvcj48YXV0aG9yPnZvbiBCYXJkZWxlYmVuLCBSLiBTLjwvYXV0aG9y

PjxhdXRob3I+U290aXJpb3UsIEUuPC9hdXRob3I+PGF1dGhvcj5TY2hhZmVyLCBVLjwvYXV0aG9y

PjxhdXRob3I+RGV1c2NobCwgRi48L2F1dGhvcj48YXV0aG9yPkt1Y2ssIEsuIEguPC9hdXRob3I+

PGF1dGhvcj5LcmVpZGVsLCBGLjwvYXV0aG9yPjxhdXRob3I+SnVsaWFyZCwgSi4gTS48L2F1dGhv

cj48YXV0aG9yPkJyb2NoZXQsIEUuPC9hdXRob3I+PGF1dGhvcj5MYXRpYiwgQS48L2F1dGhvcj48

YXV0aG9yPkFncmljb2xhLCBFLjwvYXV0aG9yPjxhdXRob3I+QmFsZHVzLCBTLjwvYXV0aG9yPjxh

dXRob3I+RnJpZWRyaWNocywgSy48L2F1dGhvcj48YXV0aG9yPlZhbmRyYW5naSwgUC48L2F1dGhv

cj48YXV0aG9yPlZlcnRhLCBQLjwvYXV0aG9yPjxhdXRob3I+SGFobiwgUi4gVC48L2F1dGhvcj48

YXV0aG9yPk1haXNhbm8sIEYuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRo

LWFkZHJlc3M+RGVwYXJ0bWVudCBvZiBDYXJkaW9sb2d5LCBVbml2ZXJzaXR5IEhvc3BpdGFsIEJv

bm4sIEJvbm4sIEdlcm1hbnkuIEVsZWN0cm9uaWMgYWRkcmVzczogZ2Vvcmcubmlja2VuaWdAdWti

b25uLmRlLiYjeEQ7RGVwYXJ0bWVudCBvZiBDYXJkaW9sb2d5LCBVbml2ZXJzaXR5IEhvc3BpdGFs

IEJvbm4sIEJvbm4sIEdlcm1hbnkuJiN4RDtMdWR3aWctTWF4aW1pbGlhbnMgVW5pdmVyc2l0eSBI

b3NwaXRhbCBNdW5pY2gsIE11bmljaCwgR2VybWFueS4mI3hEO0RlcGFydG1lbnQgb2YgQ2FyZGlv

bG9neSwgVW5pdmVyc2l0eSBNZWRpY2FsIENlbnRlciBNYWlueiwgTWFpbnosIEdlcm1hbnkuJiN4

RDtTdHJ1Y3R1cmFsIEhlYXJ0IERpdmlzaW9uLCBVbml2ZXJzaXR5IEhlYXJ0IENlbnRlciBIYW1i

dXJnLCBIYW1idXJnLCBHZXJtYW55LiYjeEQ7RGVwYXJ0bWVudCBvZiBDYXJkaW9sb2d5LCBTdC4g

R2VvcmdlIEhvc3BpdGFsLCBIYW1idXJnLCBHZXJtYW55LiYjeEQ7RGVwYXJ0bWVudCBvZiBDYXJk

aW9sb2d5LCBIb3BpdGFsIEJpY2hhdCwgQVAtSFAsIFBhcmlzLCBGcmFuY2U7IERlcGFydGVtZW50

IGRlIENhcmRpb2xvZ2llLCBVbml2ZXJzaXRlIFBhcmlzLURpZGVyb3QsIFBhcmlzLCBGcmFuY2U7

IElOU0VSTSBVLTExNDgsIFBhcmlzLCBGcmFuY2UuJiN4RDtEaXBhcnRpbWVudG8gQ2FyZGlvLVRv

cmFjby1WYXNjb2xhcmUsIFNhbiBSYWZmYWVsZSBJbnN0aXR1dGUsIE1pbGFuLCBJdGFseS4mI3hE

O0hlYXJ0IENlbnRlciwgVW5pdmVyc2l0eSBIb3NwaXRhbCBDb2xvZ25lLCBDb2xvZ25lLCBHZXJt

YW55LiYjeEQ7RWR3YXJkcyBMaWZlc2NpZW5jZXMsIElydmluZSwgQ2FsaWZvcm5pYS4mI3hEO0Nh

cmRpb3Zhc2N1bGFyIFJlc2VhcmNoIEZvdW5kYXRpb24sIE5ldyBZb3JrLCBOZXcgWW9yay4mI3hE

O0RlcGFydG1lbnQgb2YgQ2FyZGlvdmFzY3VsYXIgU3VyZ2VyeSwgVW5pdmVyc2l0eSBIb3NwaXRh

bCBadXJpY2gsIFp1cmljaCwgU3dpdHplcmxhbmQuPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0

bGU+Ni1Nb250aCBPdXRjb21lcyBvZiBUcmljdXNwaWQgVmFsdmUgUmVjb25zdHJ1Y3Rpb24gZm9y

IFBhdGllbnRzIFdpdGggU2V2ZXJlIFRyaWN1c3BpZCBSZWd1cmdpdGF0aW9uPC90aXRsZT48c2Vj

b25kYXJ5LXRpdGxlPkogQW0gQ29sbCBDYXJkaW9sPC9zZWNvbmRhcnktdGl0bGU+PC90aXRsZXM+

PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+SiBBbSBDb2xsIENhcmRpb2w8L2Z1bGwtdGl0bGU+PC9w

ZXJpb2RpY2FsPjxwYWdlcz4xOTA1LTE5MTU8L3BhZ2VzPjx2b2x1bWU+NzM8L3ZvbHVtZT48bnVt

YmVyPjE1PC9udW1iZXI+PGVkaXRpb24+MjAxOS8wNC8yMDwvZWRpdGlvbj48a2V5d29yZHM+PGtl

eXdvcmQ+VHJpLXJlcGFpcjwva2V5d29yZD48a2V5d29yZD5hbm51bGFyIHJlZHVjdGlvbjwva2V5

d29yZD48a2V5d29yZD50cmljdXNwaWQgcmVndXJnaXRhdGlvbjwva2V5d29yZD48a2V5d29yZD50

cmljdXNwaWQgcmVwYWlyPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTk8L3ll

YXI+PHB1Yi1kYXRlcz48ZGF0ZT5BcHIgMjM8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNi

bj4xNTU4LTM1OTcgKEVsZWN0cm9uaWMpJiN4RDswNzM1LTEwOTcgKExpbmtpbmcpPC9pc2JuPjxh

Y2Nlc3Npb24tbnVtPjMwOTk5OTkzPC9hY2Nlc3Npb24tbnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+

PHVybD5odHRwczovL3d3dy5uY2JpLm5sbS5uaWguZ292L3B1Ym1lZC8zMDk5OTk5MzwvdXJsPjwv

cmVsYXRlZC11cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTAxNi9qLmph

Y2MuMjAxOS4wMS4wNjI8L2VsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjwvcmVjb3JkPjwvQ2l0ZT48

L0VuZE5vdGU+AG==

ADDIN EN.CITE.DATA (16) TriBAND NCT03779490CE Mark (2018)Millipede, Boston Scientific, Marlborough, MA, USADirect ring annuloplastySurgical ADDIN EN.CITE <EndNote><Cite><Author>Rogers</Author><Year>2018</Year><RecNum>505</RecNum><DisplayText>(6)</DisplayText><record><rec-number>505</rec-number><foreign-keys><key app="EN" db-id="9weer5x0qdst05etf215txr5zasvtrtts0z5" timestamp="1580473397">505</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Rogers, J. H.</author><author>Boyd, W. D.</author><author>Smith, T. W.</author><author>Bolling, S. F.</author></authors></contributors><auth-address>Division of Cardiovascular Medicine, University of California, Davis Medical Center, Sacramento, CA, USA.&#xD;Division of Cardiothoracic Surgery, University of California, Davis Medical Center, Sacramento, CA, USA.&#xD;Department of Cardiac Surgery, University of Michigan Health System, Ann Arbor, MI, USA.</auth-address><titles><title>Early experience with Millipede IRIS transcatheter mitral annuloplasty</title><secondary-title>Ann Cardiothorac Surg</secondary-title></titles><periodical><full-title>Ann Cardiothorac Surg</full-title></periodical><pages>780-786</pages><volume>7</volume><number>6</number><edition>2019/01/02</edition><keywords><keyword>Mitral regurgitation</keyword><keyword>mitral annuloplasty</keyword><keyword>transcatheter mitral valve repair</keyword><keyword>Millipede, Inc.</keyword></keywords><dates><year>2018</year><pub-dates><date>Nov</date></pub-dates></dates><isbn>2225-319X (Print)&#xD;2225-319X (Linking)</isbn><accession-num>30598893</accession-num><urls><related-urls><url>;(6)InvestigationalDaVingi, Cardiac Implants LLC, Wilmington, DE, USARing annuloplastyRight internal jugular veinNCT03700918InvestigationalTRAIPTA, Transatrial intrapericardial tricuspid annuloplastyIndirect ring annuloplastyFemoral veinPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Sb2dlcnM8L0F1dGhvcj48WWVhcj4yMDE1PC9ZZWFyPjxS

ZWNOdW0+NDg5PC9SZWNOdW0+PERpc3BsYXlUZXh0PigxNyk8L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+

PHJlYy1udW1iZXI+NDg5PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBk

Yi1pZD0iOXdlZXI1eDBxZHN0MDVldGYyMTV0eHI1emFzdnRydHRzMHo1IiB0aW1lc3RhbXA9IjE1

ODA0NzE0NTQiPjQ4OTwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFs

IEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+Um9n

ZXJzLCBULjwvYXV0aG9yPjxhdXRob3I+UmF0bmF5YWthLCBLLjwvYXV0aG9yPjxhdXRob3I+U29u

bWV6LCBNLjwvYXV0aG9yPjxhdXRob3I+RnJhbnNvbiwgRC4gTi48L2F1dGhvcj48YXV0aG9yPlNj

aGVua2UsIFcuIEguPC9hdXRob3I+PGF1dGhvcj5NYXphbCwgSi4gUi48L2F1dGhvcj48YXV0aG9y

PktvY2F0dXJrLCBPLjwvYXV0aG9yPjxhdXRob3I+Q2hlbiwgTS4gWS48L2F1dGhvcj48YXV0aG9y

PkZhcmFuZXNoLCBBLiBaLjwvYXV0aG9yPjxhdXRob3I+TGVkZXJtYW4sIFIuIEouPC9hdXRob3I+

PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+Q2FyZGlvdmFzY3VsYXIgYW5k

IFB1bG1vbmFyeSBCcmFuY2gsIERpdmlzaW9uIG9mIEludHJhbXVyYWwgUmVzZWFyY2gsIE5hdGlv

bmFsIEhlYXJ0LCBMdW5nLCBhbmQgQmxvb2QgSW5zdGl0dXRlLCBOYXRpb25hbCBJbnN0aXR1dGVz

IG9mIEhlYWx0aCwgQmV0aGVzZGEsIE1hcnlsYW5kLiYjeEQ7Q2FyZGlvdmFzY3VsYXIgYW5kIFB1

bG1vbmFyeSBCcmFuY2gsIERpdmlzaW9uIG9mIEludHJhbXVyYWwgUmVzZWFyY2gsIE5hdGlvbmFs

IEhlYXJ0LCBMdW5nLCBhbmQgQmxvb2QgSW5zdGl0dXRlLCBOYXRpb25hbCBJbnN0aXR1dGVzIG9m

IEhlYWx0aCwgQmV0aGVzZGEsIE1hcnlsYW5kOyBEZXBhcnRtZW50IG9mIENhcmRpb2xvZ3ksIENo

aWxkcmVuJmFwb3M7cyBOYXRpb25hbCBNZWRpY2FsIENlbnRlciwgV2FzaGluZ3RvbiwgREMuJiN4

RDtDYXJkaW92YXNjdWxhciBhbmQgUHVsbW9uYXJ5IEJyYW5jaCwgRGl2aXNpb24gb2YgSW50cmFt

dXJhbCBSZXNlYXJjaCwgTmF0aW9uYWwgSGVhcnQsIEx1bmcsIGFuZCBCbG9vZCBJbnN0aXR1dGUs

IE5hdGlvbmFsIEluc3RpdHV0ZXMgb2YgSGVhbHRoLCBCZXRoZXNkYSwgTWFyeWxhbmQ7IEluc3Rp

dHV0ZSBvZiBCaW9tZWRpY2FsIEVuZ2luZWVyaW5nLCBCb2dhemljaSBVbml2ZXJzaXR5LCBJc3Rh

bmJ1bCwgVHVya2V5LiYjeEQ7Q2FyZGlvdmFzY3VsYXIgYW5kIFB1bG1vbmFyeSBCcmFuY2gsIERp

dmlzaW9uIG9mIEludHJhbXVyYWwgUmVzZWFyY2gsIE5hdGlvbmFsIEhlYXJ0LCBMdW5nLCBhbmQg

Qmxvb2QgSW5zdGl0dXRlLCBOYXRpb25hbCBJbnN0aXR1dGVzIG9mIEhlYWx0aCwgQmV0aGVzZGEs

IE1hcnlsYW5kLiBFbGVjdHJvbmljIGFkZHJlc3M6IGxlZGVybWFuQG5paC5nb3YuPC9hdXRoLWFk

ZHJlc3M+PHRpdGxlcz48dGl0bGU+VHJhbnNhdHJpYWwgaW50cmFwZXJpY2FyZGlhbCB0cmljdXNw

aWQgYW5udWxvcGxhc3R5PC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkpBQ0MgQ2FyZGlvdmFzYyBJ

bnRlcnY8L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5K

QUNDIENhcmRpb3Zhc2MgSW50ZXJ2PC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48cGFnZXM+NDgz

LTQ5MTwvcGFnZXM+PHZvbHVtZT44PC92b2x1bWU+PG51bWJlcj4zPC9udW1iZXI+PGVkaXRpb24+

MjAxNS8wMi8yNDwvZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QW5pbWFsczwva2V5d29yZD48

a2V5d29yZD5BdHJpYWwgQXBwZW5kYWdlPC9rZXl3b3JkPjxrZXl3b3JkPkNhcmRpYWMgQ2F0aGV0

ZXJpemF0aW9uL2FkdmVyc2UgZWZmZWN0cy9pbnN0cnVtZW50YXRpb24vKm1ldGhvZHM8L2tleXdv

cmQ+PGtleXdvcmQ+Q2FyZGlhYyBWYWx2ZSBBbm51bG9wbGFzdHkvYWR2ZXJzZSBlZmZlY3RzL2lu

c3RydW1lbnRhdGlvbi8qbWV0aG9kczwva2V5d29yZD48a2V5d29yZD5EaXNlYXNlIE1vZGVscywg

QW5pbWFsPC9rZXl3b3JkPjxrZXl3b3JkPkZlYXNpYmlsaXR5IFN0dWRpZXM8L2tleXdvcmQ+PGtl

eXdvcmQ+SGVhcnQgVmFsdmUgUHJvc3RoZXNpczwva2V5d29yZD48a2V5d29yZD5IZWFydCBWYWx2

ZSBQcm9zdGhlc2lzIEltcGxhbnRhdGlvbi9hZHZlcnNlIGVmZmVjdHMvaW5zdHJ1bWVudGF0aW9u

LyptZXRob2RzPC9rZXl3b3JkPjxrZXl3b3JkPkhlbW9keW5hbWljczwva2V5d29yZD48a2V5d29y

ZD5NYWduZXRpYyBSZXNvbmFuY2UgSW1hZ2luZzwva2V5d29yZD48a2V5d29yZD5Qcm9zdGhlc2lz

IERlc2lnbjwva2V5d29yZD48a2V5d29yZD5QdW5jdHVyZXM8L2tleXdvcmQ+PGtleXdvcmQ+U3dp

bmU8L2tleXdvcmQ+PGtleXdvcmQ+VGltZSBGYWN0b3JzPC9rZXl3b3JkPjxrZXl3b3JkPlRyaWN1

c3BpZCBWYWx2ZS8qcGh5c2lvcGF0aG9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPlRyaWN1c3BpZCBW

YWx2ZSBJbnN1ZmZpY2llbmN5L2V0aW9sb2d5L3BoeXNpb3BhdGhvbG9neS8qdGhlcmFweTwva2V5

d29yZD48a2V5d29yZD5hbm51bG9wbGFzdHk8L2tleXdvcmQ+PGtleXdvcmQ+c3RydWN0dXJhbCBo

ZWFydCBpbnRlcnZlbnRpb25zPC9rZXl3b3JkPjxrZXl3b3JkPnRyYW5zY2F0aGV0ZXIgcmVwYWly

PC9rZXl3b3JkPjxrZXl3b3JkPnRyaWN1c3BpZCByZWd1cmdpdGF0aW9uPC9rZXl3b3JkPjwva2V5

d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTU8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5NYXI8L2RhdGU+

PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xODc2LTc2MDUgKEVsZWN0cm9uaWMpJiN4RDsxOTM2

LTg3OTggKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjI1NzAzODcyPC9hY2Nlc3Npb24t

bnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwczovL3d3dy5uY2JpLm5sbS5uaWguZ292

L3B1Ym1lZC8yNTcwMzg3MjwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48Y3VzdG9tMj5QTUM0

NTI0NzM5PC9jdXN0b20yPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMDE2L2ouamNpbi4y

MDE0LjEwLjAxMzwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjwvRW5k

Tm90ZT4A

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Sb2dlcnM8L0F1dGhvcj48WWVhcj4yMDE1PC9ZZWFyPjxS

ZWNOdW0+NDg5PC9SZWNOdW0+PERpc3BsYXlUZXh0PigxNyk8L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+

PHJlYy1udW1iZXI+NDg5PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBk

Yi1pZD0iOXdlZXI1eDBxZHN0MDVldGYyMTV0eHI1emFzdnRydHRzMHo1IiB0aW1lc3RhbXA9IjE1

ODA0NzE0NTQiPjQ4OTwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFs

IEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+Um9n

ZXJzLCBULjwvYXV0aG9yPjxhdXRob3I+UmF0bmF5YWthLCBLLjwvYXV0aG9yPjxhdXRob3I+U29u

bWV6LCBNLjwvYXV0aG9yPjxhdXRob3I+RnJhbnNvbiwgRC4gTi48L2F1dGhvcj48YXV0aG9yPlNj

aGVua2UsIFcuIEguPC9hdXRob3I+PGF1dGhvcj5NYXphbCwgSi4gUi48L2F1dGhvcj48YXV0aG9y

PktvY2F0dXJrLCBPLjwvYXV0aG9yPjxhdXRob3I+Q2hlbiwgTS4gWS48L2F1dGhvcj48YXV0aG9y

PkZhcmFuZXNoLCBBLiBaLjwvYXV0aG9yPjxhdXRob3I+TGVkZXJtYW4sIFIuIEouPC9hdXRob3I+

PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+Q2FyZGlvdmFzY3VsYXIgYW5k

IFB1bG1vbmFyeSBCcmFuY2gsIERpdmlzaW9uIG9mIEludHJhbXVyYWwgUmVzZWFyY2gsIE5hdGlv

bmFsIEhlYXJ0LCBMdW5nLCBhbmQgQmxvb2QgSW5zdGl0dXRlLCBOYXRpb25hbCBJbnN0aXR1dGVz

IG9mIEhlYWx0aCwgQmV0aGVzZGEsIE1hcnlsYW5kLiYjeEQ7Q2FyZGlvdmFzY3VsYXIgYW5kIFB1

bG1vbmFyeSBCcmFuY2gsIERpdmlzaW9uIG9mIEludHJhbXVyYWwgUmVzZWFyY2gsIE5hdGlvbmFs

IEhlYXJ0LCBMdW5nLCBhbmQgQmxvb2QgSW5zdGl0dXRlLCBOYXRpb25hbCBJbnN0aXR1dGVzIG9m

IEhlYWx0aCwgQmV0aGVzZGEsIE1hcnlsYW5kOyBEZXBhcnRtZW50IG9mIENhcmRpb2xvZ3ksIENo

aWxkcmVuJmFwb3M7cyBOYXRpb25hbCBNZWRpY2FsIENlbnRlciwgV2FzaGluZ3RvbiwgREMuJiN4

RDtDYXJkaW92YXNjdWxhciBhbmQgUHVsbW9uYXJ5IEJyYW5jaCwgRGl2aXNpb24gb2YgSW50cmFt

dXJhbCBSZXNlYXJjaCwgTmF0aW9uYWwgSGVhcnQsIEx1bmcsIGFuZCBCbG9vZCBJbnN0aXR1dGUs

IE5hdGlvbmFsIEluc3RpdHV0ZXMgb2YgSGVhbHRoLCBCZXRoZXNkYSwgTWFyeWxhbmQ7IEluc3Rp

dHV0ZSBvZiBCaW9tZWRpY2FsIEVuZ2luZWVyaW5nLCBCb2dhemljaSBVbml2ZXJzaXR5LCBJc3Rh

bmJ1bCwgVHVya2V5LiYjeEQ7Q2FyZGlvdmFzY3VsYXIgYW5kIFB1bG1vbmFyeSBCcmFuY2gsIERp

dmlzaW9uIG9mIEludHJhbXVyYWwgUmVzZWFyY2gsIE5hdGlvbmFsIEhlYXJ0LCBMdW5nLCBhbmQg

Qmxvb2QgSW5zdGl0dXRlLCBOYXRpb25hbCBJbnN0aXR1dGVzIG9mIEhlYWx0aCwgQmV0aGVzZGEs

IE1hcnlsYW5kLiBFbGVjdHJvbmljIGFkZHJlc3M6IGxlZGVybWFuQG5paC5nb3YuPC9hdXRoLWFk

ZHJlc3M+PHRpdGxlcz48dGl0bGU+VHJhbnNhdHJpYWwgaW50cmFwZXJpY2FyZGlhbCB0cmljdXNw

aWQgYW5udWxvcGxhc3R5PC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkpBQ0MgQ2FyZGlvdmFzYyBJ

bnRlcnY8L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5K

QUNDIENhcmRpb3Zhc2MgSW50ZXJ2PC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48cGFnZXM+NDgz

LTQ5MTwvcGFnZXM+PHZvbHVtZT44PC92b2x1bWU+PG51bWJlcj4zPC9udW1iZXI+PGVkaXRpb24+

MjAxNS8wMi8yNDwvZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QW5pbWFsczwva2V5d29yZD48

a2V5d29yZD5BdHJpYWwgQXBwZW5kYWdlPC9rZXl3b3JkPjxrZXl3b3JkPkNhcmRpYWMgQ2F0aGV0

ZXJpemF0aW9uL2FkdmVyc2UgZWZmZWN0cy9pbnN0cnVtZW50YXRpb24vKm1ldGhvZHM8L2tleXdv

cmQ+PGtleXdvcmQ+Q2FyZGlhYyBWYWx2ZSBBbm51bG9wbGFzdHkvYWR2ZXJzZSBlZmZlY3RzL2lu

c3RydW1lbnRhdGlvbi8qbWV0aG9kczwva2V5d29yZD48a2V5d29yZD5EaXNlYXNlIE1vZGVscywg

QW5pbWFsPC9rZXl3b3JkPjxrZXl3b3JkPkZlYXNpYmlsaXR5IFN0dWRpZXM8L2tleXdvcmQ+PGtl

eXdvcmQ+SGVhcnQgVmFsdmUgUHJvc3RoZXNpczwva2V5d29yZD48a2V5d29yZD5IZWFydCBWYWx2

ZSBQcm9zdGhlc2lzIEltcGxhbnRhdGlvbi9hZHZlcnNlIGVmZmVjdHMvaW5zdHJ1bWVudGF0aW9u

LyptZXRob2RzPC9rZXl3b3JkPjxrZXl3b3JkPkhlbW9keW5hbWljczwva2V5d29yZD48a2V5d29y

ZD5NYWduZXRpYyBSZXNvbmFuY2UgSW1hZ2luZzwva2V5d29yZD48a2V5d29yZD5Qcm9zdGhlc2lz

IERlc2lnbjwva2V5d29yZD48a2V5d29yZD5QdW5jdHVyZXM8L2tleXdvcmQ+PGtleXdvcmQ+U3dp

bmU8L2tleXdvcmQ+PGtleXdvcmQ+VGltZSBGYWN0b3JzPC9rZXl3b3JkPjxrZXl3b3JkPlRyaWN1

c3BpZCBWYWx2ZS8qcGh5c2lvcGF0aG9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPlRyaWN1c3BpZCBW

YWx2ZSBJbnN1ZmZpY2llbmN5L2V0aW9sb2d5L3BoeXNpb3BhdGhvbG9neS8qdGhlcmFweTwva2V5

d29yZD48a2V5d29yZD5hbm51bG9wbGFzdHk8L2tleXdvcmQ+PGtleXdvcmQ+c3RydWN0dXJhbCBo

ZWFydCBpbnRlcnZlbnRpb25zPC9rZXl3b3JkPjxrZXl3b3JkPnRyYW5zY2F0aGV0ZXIgcmVwYWly

PC9rZXl3b3JkPjxrZXl3b3JkPnRyaWN1c3BpZCByZWd1cmdpdGF0aW9uPC9rZXl3b3JkPjwva2V5

d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTU8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5NYXI8L2RhdGU+

PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xODc2LTc2MDUgKEVsZWN0cm9uaWMpJiN4RDsxOTM2

LTg3OTggKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjI1NzAzODcyPC9hY2Nlc3Npb24t

bnVtPjx1cmxzPjxyZWxhdGVkLXVybHM+PHVybD5odHRwczovL3d3dy5uY2JpLm5sbS5uaWguZ292

L3B1Ym1lZC8yNTcwMzg3MjwvdXJsPjwvcmVsYXRlZC11cmxzPjwvdXJscz48Y3VzdG9tMj5QTUM0

NTI0NzM5PC9jdXN0b20yPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMDE2L2ouamNpbi4y

MDE0LjEwLjAxMzwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PC9yZWNvcmQ+PC9DaXRlPjwvRW5k

Tm90ZT4A

ADDIN EN.CITE.DATA (17)InvestigationalTriClip, Abbott Vascular, Santa Clara, CA, USACoaptation enhancementFemoral veinTRILUMINATENCT03227757InvestigationalPASCAL, Edwards Lifesciences, Irvine, CA, USACoaptation enhancementFemoral vein PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QcmF6PC9BdXRob3I+PFllYXI+MjAxNzwvWWVhcj48UmVj

TnVtPjQyNjwvUmVjTnVtPjxEaXNwbGF5VGV4dD4oMTgpPC9EaXNwbGF5VGV4dD48cmVjb3JkPjxy

ZWMtbnVtYmVyPjQyNjwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGIt

aWQ9Ijl3ZWVyNXgwcWRzdDA1ZXRmMjE1dHhyNXphc3Z0cnR0czB6NSIgdGltZXN0YW1wPSIxNTgw

NDY4MzU2Ij40MjY8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBB

cnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPlByYXos

IEYuPC9hdXRob3I+PGF1dGhvcj5TcGFyZ2lhcywgSy48L2F1dGhvcj48YXV0aG9yPkNocmlzc29o

ZXJpcywgTS48L2F1dGhvcj48YXV0aG9yPkJ1bGxlc2ZlbGQsIEwuPC9hdXRob3I+PGF1dGhvcj5O

aWNrZW5pZywgRy48L2F1dGhvcj48YXV0aG9yPkRldXNjaGwsIEYuPC9hdXRob3I+PGF1dGhvcj5T

Y2h1ZWxlciwgUi48L2F1dGhvcj48YXV0aG9yPkZhbSwgTi4gUC48L2F1dGhvcj48YXV0aG9yPk1v

c3MsIFIuPC9hdXRob3I+PGF1dGhvcj5NYWthciwgTS48L2F1dGhvcj48YXV0aG9yPkJvb25lLCBS

LjwvYXV0aG9yPjxhdXRob3I+RWR3YXJkcywgSi48L2F1dGhvcj48YXV0aG9yPk1vc2Nob3ZpdGlz

LCBBLjwvYXV0aG9yPjxhdXRob3I+S2FyLCBTLjwvYXV0aG9yPjxhdXRob3I+V2ViYiwgSi48L2F1

dGhvcj48YXV0aG9yPlNjaGFmZXIsIFUuPC9hdXRob3I+PGF1dGhvcj5GZWxkbWFuLCBULjwvYXV0

aG9yPjxhdXRob3I+V2luZGVja2VyLCBTLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9y

cz48YXV0aC1hZGRyZXNzPkRlcGFydG1lbnQgb2YgQ2FyZGlvbG9neSwgVW5pdmVyc2l0eSBIb3Nw

aXRhbCBCZXJuLCBCZXJuLCBTd2l0emVybGFuZC4mI3hEO0RlcGFydG1lbnQgb2YgVHJhbnNjYXRo

ZXRlciBIZWFydCBWYWx2ZXMsIEh5Z2VpYSBIb3NwaXRhbCwgQXRoZW5zLCBHcmVlY2UuJiN4RDtE

ZXBhcnRtZW50IG9mIEludGVybmFsIE1lZGljaW5lIGFuZCBDYXJkaW9sb2d5LCBHRk8gSG9zcGl0

YWxzIEJvbm4sIEJvbm4sIEdlcm1hbnkuJiN4RDtEZXBhcnRtZW50IG9mIE1lZGljaW5lIElJLCBI

ZWFydCBDZW50ZXIgQm9ubiwgVW5pdmVyc2l0eSBIb3NwaXRhbCBCb25uLCBCb25uLCBHZXJtYW55

LiYjeEQ7RGVwYXJ0bWVudCBvZiBHZW5lcmFsIGFuZCBJbnRlcnZlbnRpb25hbCBDYXJkaW9sb2d5

LCBVbml2ZXJzaXR5IEhlYXJ0IENlbnRlciBIYW1idXJnLCBIYW1idXJnLCBHZXJtYW55LiYjeEQ7

U3QgTWljaGFlbCZhcG9zO3MgSG9zcGl0YWwsIERpdmlzaW9uIG9mIENhcmRpb2xvZ3ksIFVuaXZl

cnNpdHkgb2YgVG9yb250bywgVG9yb250bywgT04sIENhbmFkYS4mI3hEO1N0IFBhdWwmYXBvcztz

IEhvc3BpdGFsLCBVbml2ZXJzaXR5IG9mIEJyaXRpc2ggQ29sdW1iaWEsIFZhbmNvdXZlciwgQkMs

IENhbmFkYS4mI3hEO0NlZGFycy1TaW5haSBNZWRpY2FsIENlbnRlciwgTG9zIEFuZ2VsZXMsIENB

LCBVU0EuJiN4RDtEZXBhcnRtZW50IG9mIENhcmRpb2xvZ3ksIEV2YW5zdG9uIEhvc3BpdGFsLCBO

b3J0aFNob3JlIFVuaXZlcnNpdHkgSGVhbHRoIFN5c3RlbSwgRXZhbnN0b24sIElMLCBVU0EuJiN4

RDtEZXBhcnRtZW50IG9mIENhcmRpb2xvZ3ksIFVuaXZlcnNpdHkgSG9zcGl0YWwgQmVybiwgQmVy

biwgU3dpdHplcmxhbmQuIEVsZWN0cm9uaWMgYWRkcmVzczogc3RlcGhhbi53aW5kZWNrZXJAaW5z

ZWwuY2guPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+Q29tcGFzc2lvbmF0ZSB1c2Ugb2Yg

dGhlIFBBU0NBTCB0cmFuc2NhdGhldGVyIG1pdHJhbCB2YWx2ZSByZXBhaXIgc3lzdGVtIGZvciBw

YXRpZW50cyB3aXRoIHNldmVyZSBtaXRyYWwgcmVndXJnaXRhdGlvbjogYSBtdWx0aWNlbnRyZSwg

cHJvc3BlY3RpdmUsIG9ic2VydmF0aW9uYWwsIGZpcnN0LWluLW1hbiBzdHVkeTwvdGl0bGU+PHNl

Y29uZGFyeS10aXRsZT5MYW5jZXQ8L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNh

bD48ZnVsbC10aXRsZT5MYW5jZXQ8L2Z1bGwtdGl0bGU+PC9wZXJpb2RpY2FsPjxwYWdlcz43NzMt

NzgwPC9wYWdlcz48dm9sdW1lPjM5MDwvdm9sdW1lPjxudW1iZXI+MTAwOTY8L251bWJlcj48ZWRp

dGlvbj4yMDE3LzA4LzI0PC9lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5BZ2VkPC9rZXl3b3Jk

PjxrZXl3b3JkPkFnZWQsIDgwIGFuZCBvdmVyPC9rZXl3b3JkPjxrZXl3b3JkPkNvbXBhc3Npb25h

dGUgVXNlIFRyaWFsczwva2V5d29yZD48a2V5d29yZD5FY2hvY2FyZGlvZ3JhcGh5LCBEb3BwbGVy

LCBDb2xvcjwva2V5d29yZD48a2V5d29yZD5FcXVpcG1lbnQgRGVzaWduPC9rZXl3b3JkPjxrZXl3

b3JkPkZlYXNpYmlsaXR5IFN0dWRpZXM8L2tleXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3Jk

PjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3b3Jk

Pk1pZGRsZSBBZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPk1pdHJhbCBWYWx2ZSBBbm51bG9wbGFzdHkv

aW5zdHJ1bWVudGF0aW9uLyptZXRob2RzPC9rZXl3b3JkPjxrZXl3b3JkPk1pdHJhbCBWYWx2ZSBJ

bnN1ZmZpY2llbmN5L2RpYWdub3N0aWMgaW1hZ2luZy9waHlzaW9wYXRob2xvZ3kvKnN1cmdlcnk8

L2tleXdvcmQ+PGtleXdvcmQ+UHJvc3BlY3RpdmUgU3R1ZGllczwva2V5d29yZD48a2V5d29yZD5U

cmVhdG1lbnQgT3V0Y29tZTwva2V5d29yZD48a2V5d29yZD5WZW50cmljdWxhciBEeXNmdW5jdGlv

biwgTGVmdC9ldGlvbG9neTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDE3PC95

ZWFyPjxwdWItZGF0ZXM+PGRhdGU+QXVnIDE5PC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlz

Ym4+MTQ3NC01NDdYIChFbGVjdHJvbmljKSYjeEQ7MDE0MC02NzM2IChMaW5raW5nKTwvaXNibj48

YWNjZXNzaW9uLW51bT4yODgzMTk5MzwvYWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11cmxz

Pjx1cmw+aHR0cHM6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMjg4MzE5OTM8L3VybD48

L3JlbGF0ZWQtdXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEwMTYvUzAx

NDAtNjczNigxNykzMTYwMC04PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48L3JlY29yZD48L0Np

dGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5QcmF6PC9BdXRob3I+PFllYXI+MjAxNzwvWWVhcj48UmVj

TnVtPjQyNjwvUmVjTnVtPjxEaXNwbGF5VGV4dD4oMTgpPC9EaXNwbGF5VGV4dD48cmVjb3JkPjxy

ZWMtbnVtYmVyPjQyNjwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGIt

aWQ9Ijl3ZWVyNXgwcWRzdDA1ZXRmMjE1dHhyNXphc3Z0cnR0czB6NSIgdGltZXN0YW1wPSIxNTgw

NDY4MzU2Ij40MjY8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBB

cnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPlByYXos

IEYuPC9hdXRob3I+PGF1dGhvcj5TcGFyZ2lhcywgSy48L2F1dGhvcj48YXV0aG9yPkNocmlzc29o

ZXJpcywgTS48L2F1dGhvcj48YXV0aG9yPkJ1bGxlc2ZlbGQsIEwuPC9hdXRob3I+PGF1dGhvcj5O

aWNrZW5pZywgRy48L2F1dGhvcj48YXV0aG9yPkRldXNjaGwsIEYuPC9hdXRob3I+PGF1dGhvcj5T

Y2h1ZWxlciwgUi48L2F1dGhvcj48YXV0aG9yPkZhbSwgTi4gUC48L2F1dGhvcj48YXV0aG9yPk1v

c3MsIFIuPC9hdXRob3I+PGF1dGhvcj5NYWthciwgTS48L2F1dGhvcj48YXV0aG9yPkJvb25lLCBS

LjwvYXV0aG9yPjxhdXRob3I+RWR3YXJkcywgSi48L2F1dGhvcj48YXV0aG9yPk1vc2Nob3ZpdGlz

LCBBLjwvYXV0aG9yPjxhdXRob3I+S2FyLCBTLjwvYXV0aG9yPjxhdXRob3I+V2ViYiwgSi48L2F1

dGhvcj48YXV0aG9yPlNjaGFmZXIsIFUuPC9hdXRob3I+PGF1dGhvcj5GZWxkbWFuLCBULjwvYXV0

aG9yPjxhdXRob3I+V2luZGVja2VyLCBTLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1dG9y

cz48YXV0aC1hZGRyZXNzPkRlcGFydG1lbnQgb2YgQ2FyZGlvbG9neSwgVW5pdmVyc2l0eSBIb3Nw

aXRhbCBCZXJuLCBCZXJuLCBTd2l0emVybGFuZC4mI3hEO0RlcGFydG1lbnQgb2YgVHJhbnNjYXRo

ZXRlciBIZWFydCBWYWx2ZXMsIEh5Z2VpYSBIb3NwaXRhbCwgQXRoZW5zLCBHcmVlY2UuJiN4RDtE

ZXBhcnRtZW50IG9mIEludGVybmFsIE1lZGljaW5lIGFuZCBDYXJkaW9sb2d5LCBHRk8gSG9zcGl0

YWxzIEJvbm4sIEJvbm4sIEdlcm1hbnkuJiN4RDtEZXBhcnRtZW50IG9mIE1lZGljaW5lIElJLCBI

ZWFydCBDZW50ZXIgQm9ubiwgVW5pdmVyc2l0eSBIb3NwaXRhbCBCb25uLCBCb25uLCBHZXJtYW55

LiYjeEQ7RGVwYXJ0bWVudCBvZiBHZW5lcmFsIGFuZCBJbnRlcnZlbnRpb25hbCBDYXJkaW9sb2d5

LCBVbml2ZXJzaXR5IEhlYXJ0IENlbnRlciBIYW1idXJnLCBIYW1idXJnLCBHZXJtYW55LiYjeEQ7

U3QgTWljaGFlbCZhcG9zO3MgSG9zcGl0YWwsIERpdmlzaW9uIG9mIENhcmRpb2xvZ3ksIFVuaXZl

cnNpdHkgb2YgVG9yb250bywgVG9yb250bywgT04sIENhbmFkYS4mI3hEO1N0IFBhdWwmYXBvcztz

IEhvc3BpdGFsLCBVbml2ZXJzaXR5IG9mIEJyaXRpc2ggQ29sdW1iaWEsIFZhbmNvdXZlciwgQkMs

IENhbmFkYS4mI3hEO0NlZGFycy1TaW5haSBNZWRpY2FsIENlbnRlciwgTG9zIEFuZ2VsZXMsIENB

LCBVU0EuJiN4RDtEZXBhcnRtZW50IG9mIENhcmRpb2xvZ3ksIEV2YW5zdG9uIEhvc3BpdGFsLCBO

b3J0aFNob3JlIFVuaXZlcnNpdHkgSGVhbHRoIFN5c3RlbSwgRXZhbnN0b24sIElMLCBVU0EuJiN4

RDtEZXBhcnRtZW50IG9mIENhcmRpb2xvZ3ksIFVuaXZlcnNpdHkgSG9zcGl0YWwgQmVybiwgQmVy

biwgU3dpdHplcmxhbmQuIEVsZWN0cm9uaWMgYWRkcmVzczogc3RlcGhhbi53aW5kZWNrZXJAaW5z

ZWwuY2guPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+Q29tcGFzc2lvbmF0ZSB1c2Ugb2Yg

dGhlIFBBU0NBTCB0cmFuc2NhdGhldGVyIG1pdHJhbCB2YWx2ZSByZXBhaXIgc3lzdGVtIGZvciBw

YXRpZW50cyB3aXRoIHNldmVyZSBtaXRyYWwgcmVndXJnaXRhdGlvbjogYSBtdWx0aWNlbnRyZSwg

cHJvc3BlY3RpdmUsIG9ic2VydmF0aW9uYWwsIGZpcnN0LWluLW1hbiBzdHVkeTwvdGl0bGU+PHNl

Y29uZGFyeS10aXRsZT5MYW5jZXQ8L3NlY29uZGFyeS10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNh

bD48ZnVsbC10aXRsZT5MYW5jZXQ8L2Z1bGwtdGl0bGU+PC9wZXJpb2RpY2FsPjxwYWdlcz43NzMt

NzgwPC9wYWdlcz48dm9sdW1lPjM5MDwvdm9sdW1lPjxudW1iZXI+MTAwOTY8L251bWJlcj48ZWRp

dGlvbj4yMDE3LzA4LzI0PC9lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5BZ2VkPC9rZXl3b3Jk

PjxrZXl3b3JkPkFnZWQsIDgwIGFuZCBvdmVyPC9rZXl3b3JkPjxrZXl3b3JkPkNvbXBhc3Npb25h

dGUgVXNlIFRyaWFsczwva2V5d29yZD48a2V5d29yZD5FY2hvY2FyZGlvZ3JhcGh5LCBEb3BwbGVy

LCBDb2xvcjwva2V5d29yZD48a2V5d29yZD5FcXVpcG1lbnQgRGVzaWduPC9rZXl3b3JkPjxrZXl3

b3JkPkZlYXNpYmlsaXR5IFN0dWRpZXM8L2tleXdvcmQ+PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3Jk

PjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5NYWxlPC9rZXl3b3JkPjxrZXl3b3Jk

Pk1pZGRsZSBBZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPk1pdHJhbCBWYWx2ZSBBbm51bG9wbGFzdHkv

aW5zdHJ1bWVudGF0aW9uLyptZXRob2RzPC9rZXl3b3JkPjxrZXl3b3JkPk1pdHJhbCBWYWx2ZSBJ

bnN1ZmZpY2llbmN5L2RpYWdub3N0aWMgaW1hZ2luZy9waHlzaW9wYXRob2xvZ3kvKnN1cmdlcnk8

L2tleXdvcmQ+PGtleXdvcmQ+UHJvc3BlY3RpdmUgU3R1ZGllczwva2V5d29yZD48a2V5d29yZD5U

cmVhdG1lbnQgT3V0Y29tZTwva2V5d29yZD48a2V5d29yZD5WZW50cmljdWxhciBEeXNmdW5jdGlv

biwgTGVmdC9ldGlvbG9neTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4yMDE3PC95

ZWFyPjxwdWItZGF0ZXM+PGRhdGU+QXVnIDE5PC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlz

Ym4+MTQ3NC01NDdYIChFbGVjdHJvbmljKSYjeEQ7MDE0MC02NzM2IChMaW5raW5nKTwvaXNibj48

YWNjZXNzaW9uLW51bT4yODgzMTk5MzwvYWNjZXNzaW9uLW51bT48dXJscz48cmVsYXRlZC11cmxz

Pjx1cmw+aHR0cHM6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMjg4MzE5OTM8L3VybD48

L3JlbGF0ZWQtdXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEwLjEwMTYvUzAx

NDAtNjczNigxNykzMTYwMC04PC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48L3JlY29yZD48L0Np

dGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE.DATA (18)InvestigationalTranscatheter Tricuspid Valve ReplacementDevice/ManufacturerDevice characteristicsAccessStudyApprovalNaviGate, NaviGate Cardiac Structures, Lake Forest, CA, USASelf-expanding bioprosthesis with annular wingletsRight jugular, trans-atrialPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5OYXZpYTwvQXV0aG9yPjxZZWFyPjIwMTc8L1llYXI+PFJl

Y051bT40OTA8L1JlY051bT48RGlzcGxheVRleHQ+KDE5KTwvRGlzcGxheVRleHQ+PHJlY29yZD48

cmVjLW51bWJlcj40OTA8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRi

LWlkPSI5d2VlcjV4MHFkc3QwNWV0ZjIxNXR4cjV6YXN2dHJ0dHMwejUiIHRpbWVzdGFtcD0iMTU4

MDQ3MTUxNSI+NDkwPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwg

QXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5OYXZp

YSwgSi4gTC48L2F1dGhvcj48YXV0aG9yPkthcGFkaWEsIFMuPC9hdXRob3I+PGF1dGhvcj5FbGdo

YXJhYmx5LCBILjwvYXV0aG9yPjxhdXRob3I+SGFyYiwgUy4gQy48L2F1dGhvcj48YXV0aG9yPkty

aXNobmFzd2FteSwgQS48L2F1dGhvcj48YXV0aG9yPlVuYWksIFMuPC9hdXRob3I+PGF1dGhvcj5N

aWNrLCBTLjwvYXV0aG9yPjxhdXRob3I+Um9kcmlndWV6LCBMLjwvYXV0aG9yPjxhdXRob3I+SGFt

bWVyLCBELjwvYXV0aG9yPjxhdXRob3I+R2lsbGlub3YsIEEuIE0uPC9hdXRob3I+PGF1dGhvcj5T

dmVuc3NvbiwgTC4gRy48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRk

cmVzcz5Gcm9tIHRoZSBEZXBhcnRtZW50cyBvZiBUaG9yYWNpYyBhbmQgQ2FyZGlvdmFzY3VsYXIg

U3VyZ2VyeSAoSi5MLk4uLCBILkUuLCBTLlUuLCBTLk0uLCBBLk0uRy4sIEwuRy5TLikgYW5kIENh

cmRpb3Zhc2N1bGFyIE1lZGljaW5lIChTLksuLCBTLkMuSC4sIEEuSy4sIEwuUi4sIEQuSC4pLCBD

bGV2ZWxhbmQgQ2xpbmljLCBPSC4gbmF2aWFqQGNjZi5vcmcuJiN4RDtGcm9tIHRoZSBEZXBhcnRt

ZW50cyBvZiBUaG9yYWNpYyBhbmQgQ2FyZGlvdmFzY3VsYXIgU3VyZ2VyeSAoSi5MLk4uLCBILkUu

LCBTLlUuLCBTLk0uLCBBLk0uRy4sIEwuRy5TLikgYW5kIENhcmRpb3Zhc2N1bGFyIE1lZGljaW5l

IChTLksuLCBTLkMuSC4sIEEuSy4sIEwuUi4sIEQuSC4pLCBDbGV2ZWxhbmQgQ2xpbmljLCBPSC48

L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5GaXJzdC1pbi1IdW1hbiBJbXBsYW50YXRpb25z

IG9mIHRoZSBOYXZpR2F0ZSBCaW9wcm9zdGhlc2lzIGluIGEgU2V2ZXJlbHkgRGlsYXRlZCBUcmlj

dXNwaWQgQW5udWx1cyBhbmQgaW4gYSBGYWlsZWQgVHJpY3VzcGlkIEFubnVsb3BsYXN0eSBSaW5n

PC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkNpcmMgQ2FyZGlvdmFzYyBJbnRlcnY8L3NlY29uZGFy

eS10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5DaXJjIENhcmRpb3Zhc2Mg

SW50ZXJ2PC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48dm9sdW1lPjEwPC92b2x1bWU+PG51bWJl

cj4xMjwvbnVtYmVyPjxlZGl0aW9uPjIwMTcvMTIvMTc8L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3

b3JkPkFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+KkJpb3Byb3N0aGVzaXM8L2tleXdvcmQ+PGtleXdv

cmQ+Q2FyZGlhYyBDYXRoZXRlcml6YXRpb24vKmluc3RydW1lbnRhdGlvbi9tZXRob2RzPC9rZXl3

b3JkPjxrZXl3b3JkPkNhcmRpYWMgVmFsdmUgQW5udWxvcGxhc3R5L2FkdmVyc2UgZWZmZWN0cy8q

aW5zdHJ1bWVudGF0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPkNvbXBhc3Npb25hdGUgVXNlIFRyaWFs

czwva2V5d29yZD48a2V5d29yZD5FY2hvY2FyZGlvZ3JhcGh5LCBEb3BwbGVyLCBDb2xvcjwva2V5

d29yZD48a2V5d29yZD5FY2hvY2FyZGlvZ3JhcGh5LCBUcmFuc2Vzb3BoYWdlYWw8L2tleXdvcmQ+

PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPipIZWFydCBWYWx2ZSBQcm9zdGhlc2lz

PC9rZXl3b3JkPjxrZXl3b3JkPkhlYXJ0IFZhbHZlIFByb3N0aGVzaXMgSW1wbGFudGF0aW9uL2Fk

dmVyc2UgZWZmZWN0cy8qaW5zdHJ1bWVudGF0aW9uL21ldGhvZHM8L2tleXdvcmQ+PGtleXdvcmQ+

SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPk1pZGRsZSBBZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPk1v

ZGVscywgQW5hdG9taWM8L2tleXdvcmQ+PGtleXdvcmQ+TW9kZWxzLCBDYXJkaW92YXNjdWxhcjwv

a2V5d29yZD48a2V5d29yZD5QcmludGluZywgVGhyZWUtRGltZW5zaW9uYWw8L2tleXdvcmQ+PGtl

eXdvcmQ+UHJvc3RoZXNpcyBEZXNpZ248L2tleXdvcmQ+PGtleXdvcmQ+KlByb3N0aGVzaXMgRmFp

bHVyZTwva2V5d29yZD48a2V5d29yZD5SZWNvdmVyeSBvZiBGdW5jdGlvbjwva2V5d29yZD48a2V5

d29yZD5Ub21vZ3JhcGh5LCBYLVJheSBDb21wdXRlZDwva2V5d29yZD48a2V5d29yZD5UcmVhdG1l

bnQgT3V0Y29tZTwva2V5d29yZD48a2V5d29yZD5UcmljdXNwaWQgVmFsdmUvZGlhZ25vc3RpYyBp

bWFnaW5nL3BoeXNpb3BhdGhvbG9neS8qc3VyZ2VyeTwva2V5d29yZD48a2V5d29yZD5UcmljdXNw

aWQgVmFsdmUgSW5zdWZmaWNpZW5jeS9kaWFnbm9zdGljIGltYWdpbmcvcGh5c2lvcGF0aG9sb2d5

LypzdXJnZXJ5PC9rZXl3b3JkPjxrZXl3b3JkPipibG9vZCBwcmVzc3VyZTwva2V5d29yZD48a2V5

d29yZD4qaGVhcnQgZmFpbHVyZTwva2V5d29yZD48a2V5d29yZD4qdGhvcmFjb3RvbXk8L2tleXdv

cmQ+PGtleXdvcmQ+KnRyaWN1c3BpZCB2YWx2ZTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48

eWVhcj4yMDE3PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+RGVjPC9kYXRlPjwvcHViLWRhdGVzPjwv

ZGF0ZXM+PGlzYm4+MTk0MS03NjMyIChFbGVjdHJvbmljKSYjeEQ7MTk0MS03NjQwIChMaW5raW5n

KTwvaXNibj48YWNjZXNzaW9uLW51bT4yOTI0NjkxNTwvYWNjZXNzaW9uLW51bT48dXJscz48cmVs

YXRlZC11cmxzPjx1cmw+aHR0cHM6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMjkyNDY5

MTU8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEw

LjExNjEvQ0lSQ0lOVEVSVkVOVElPTlMuMTE3LjAwNTg0MDwvZWxlY3Ryb25pYy1yZXNvdXJjZS1u

dW0+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT5=

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5OYXZpYTwvQXV0aG9yPjxZZWFyPjIwMTc8L1llYXI+PFJl

Y051bT40OTA8L1JlY051bT48RGlzcGxheVRleHQ+KDE5KTwvRGlzcGxheVRleHQ+PHJlY29yZD48

cmVjLW51bWJlcj40OTA8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRi

LWlkPSI5d2VlcjV4MHFkc3QwNWV0ZjIxNXR4cjV6YXN2dHJ0dHMwejUiIHRpbWVzdGFtcD0iMTU4

MDQ3MTUxNSI+NDkwPC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwg

QXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5OYXZp

YSwgSi4gTC48L2F1dGhvcj48YXV0aG9yPkthcGFkaWEsIFMuPC9hdXRob3I+PGF1dGhvcj5FbGdo

YXJhYmx5LCBILjwvYXV0aG9yPjxhdXRob3I+SGFyYiwgUy4gQy48L2F1dGhvcj48YXV0aG9yPkty

aXNobmFzd2FteSwgQS48L2F1dGhvcj48YXV0aG9yPlVuYWksIFMuPC9hdXRob3I+PGF1dGhvcj5N

aWNrLCBTLjwvYXV0aG9yPjxhdXRob3I+Um9kcmlndWV6LCBMLjwvYXV0aG9yPjxhdXRob3I+SGFt

bWVyLCBELjwvYXV0aG9yPjxhdXRob3I+R2lsbGlub3YsIEEuIE0uPC9hdXRob3I+PGF1dGhvcj5T

dmVuc3NvbiwgTC4gRy48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRk

cmVzcz5Gcm9tIHRoZSBEZXBhcnRtZW50cyBvZiBUaG9yYWNpYyBhbmQgQ2FyZGlvdmFzY3VsYXIg

U3VyZ2VyeSAoSi5MLk4uLCBILkUuLCBTLlUuLCBTLk0uLCBBLk0uRy4sIEwuRy5TLikgYW5kIENh

cmRpb3Zhc2N1bGFyIE1lZGljaW5lIChTLksuLCBTLkMuSC4sIEEuSy4sIEwuUi4sIEQuSC4pLCBD

bGV2ZWxhbmQgQ2xpbmljLCBPSC4gbmF2aWFqQGNjZi5vcmcuJiN4RDtGcm9tIHRoZSBEZXBhcnRt

ZW50cyBvZiBUaG9yYWNpYyBhbmQgQ2FyZGlvdmFzY3VsYXIgU3VyZ2VyeSAoSi5MLk4uLCBILkUu

LCBTLlUuLCBTLk0uLCBBLk0uRy4sIEwuRy5TLikgYW5kIENhcmRpb3Zhc2N1bGFyIE1lZGljaW5l

IChTLksuLCBTLkMuSC4sIEEuSy4sIEwuUi4sIEQuSC4pLCBDbGV2ZWxhbmQgQ2xpbmljLCBPSC48

L2F1dGgtYWRkcmVzcz48dGl0bGVzPjx0aXRsZT5GaXJzdC1pbi1IdW1hbiBJbXBsYW50YXRpb25z

IG9mIHRoZSBOYXZpR2F0ZSBCaW9wcm9zdGhlc2lzIGluIGEgU2V2ZXJlbHkgRGlsYXRlZCBUcmlj

dXNwaWQgQW5udWx1cyBhbmQgaW4gYSBGYWlsZWQgVHJpY3VzcGlkIEFubnVsb3BsYXN0eSBSaW5n

PC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkNpcmMgQ2FyZGlvdmFzYyBJbnRlcnY8L3NlY29uZGFy

eS10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5DaXJjIENhcmRpb3Zhc2Mg

SW50ZXJ2PC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48dm9sdW1lPjEwPC92b2x1bWU+PG51bWJl

cj4xMjwvbnVtYmVyPjxlZGl0aW9uPjIwMTcvMTIvMTc8L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3

b3JkPkFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+KkJpb3Byb3N0aGVzaXM8L2tleXdvcmQ+PGtleXdv

cmQ+Q2FyZGlhYyBDYXRoZXRlcml6YXRpb24vKmluc3RydW1lbnRhdGlvbi9tZXRob2RzPC9rZXl3

b3JkPjxrZXl3b3JkPkNhcmRpYWMgVmFsdmUgQW5udWxvcGxhc3R5L2FkdmVyc2UgZWZmZWN0cy8q

aW5zdHJ1bWVudGF0aW9uPC9rZXl3b3JkPjxrZXl3b3JkPkNvbXBhc3Npb25hdGUgVXNlIFRyaWFs

czwva2V5d29yZD48a2V5d29yZD5FY2hvY2FyZGlvZ3JhcGh5LCBEb3BwbGVyLCBDb2xvcjwva2V5

d29yZD48a2V5d29yZD5FY2hvY2FyZGlvZ3JhcGh5LCBUcmFuc2Vzb3BoYWdlYWw8L2tleXdvcmQ+

PGtleXdvcmQ+RmVtYWxlPC9rZXl3b3JkPjxrZXl3b3JkPipIZWFydCBWYWx2ZSBQcm9zdGhlc2lz

PC9rZXl3b3JkPjxrZXl3b3JkPkhlYXJ0IFZhbHZlIFByb3N0aGVzaXMgSW1wbGFudGF0aW9uL2Fk

dmVyc2UgZWZmZWN0cy8qaW5zdHJ1bWVudGF0aW9uL21ldGhvZHM8L2tleXdvcmQ+PGtleXdvcmQ+

SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPk1pZGRsZSBBZ2VkPC9rZXl3b3JkPjxrZXl3b3JkPk1v

ZGVscywgQW5hdG9taWM8L2tleXdvcmQ+PGtleXdvcmQ+TW9kZWxzLCBDYXJkaW92YXNjdWxhcjwv

a2V5d29yZD48a2V5d29yZD5QcmludGluZywgVGhyZWUtRGltZW5zaW9uYWw8L2tleXdvcmQ+PGtl

eXdvcmQ+UHJvc3RoZXNpcyBEZXNpZ248L2tleXdvcmQ+PGtleXdvcmQ+KlByb3N0aGVzaXMgRmFp

bHVyZTwva2V5d29yZD48a2V5d29yZD5SZWNvdmVyeSBvZiBGdW5jdGlvbjwva2V5d29yZD48a2V5

d29yZD5Ub21vZ3JhcGh5LCBYLVJheSBDb21wdXRlZDwva2V5d29yZD48a2V5d29yZD5UcmVhdG1l

bnQgT3V0Y29tZTwva2V5d29yZD48a2V5d29yZD5UcmljdXNwaWQgVmFsdmUvZGlhZ25vc3RpYyBp

bWFnaW5nL3BoeXNpb3BhdGhvbG9neS8qc3VyZ2VyeTwva2V5d29yZD48a2V5d29yZD5UcmljdXNw

aWQgVmFsdmUgSW5zdWZmaWNpZW5jeS9kaWFnbm9zdGljIGltYWdpbmcvcGh5c2lvcGF0aG9sb2d5

LypzdXJnZXJ5PC9rZXl3b3JkPjxrZXl3b3JkPipibG9vZCBwcmVzc3VyZTwva2V5d29yZD48a2V5

d29yZD4qaGVhcnQgZmFpbHVyZTwva2V5d29yZD48a2V5d29yZD4qdGhvcmFjb3RvbXk8L2tleXdv

cmQ+PGtleXdvcmQ+KnRyaWN1c3BpZCB2YWx2ZTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48

eWVhcj4yMDE3PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+RGVjPC9kYXRlPjwvcHViLWRhdGVzPjwv

ZGF0ZXM+PGlzYm4+MTk0MS03NjMyIChFbGVjdHJvbmljKSYjeEQ7MTk0MS03NjQwIChMaW5raW5n

KTwvaXNibj48YWNjZXNzaW9uLW51bT4yOTI0NjkxNTwvYWNjZXNzaW9uLW51bT48dXJscz48cmVs

YXRlZC11cmxzPjx1cmw+aHR0cHM6Ly93d3cubmNiaS5ubG0ubmloLmdvdi9wdWJtZWQvMjkyNDY5

MTU8L3VybD48L3JlbGF0ZWQtdXJscz48L3VybHM+PGVsZWN0cm9uaWMtcmVzb3VyY2UtbnVtPjEw

LjExNjEvQ0lSQ0lOVEVSVkVOVElPTlMuMTE3LjAwNTg0MDwvZWxlY3Ryb25pYy1yZXNvdXJjZS1u

dW0+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT5=

ADDIN EN.CITE.DATA (19)InvestigationalLux, Jenscare Biotechnology, Ningbo, ChinaSelf-expanding bioprosthesis with self adaptive skirt and anchoring mechanismTrans-atrialPreclinical evaluationInvestigationalTrisol, Trisol Medical, Yokneam, IsrealSelf-expanding bioprosthesis with outer skirt and multiple anchorsJugular veinPreclinical evaluationInvestigationalTRiCares, Tricares, SAS, Paris, FranceSelf-expanding bioprosthesisJugular veinPreclinical evaluationInvestigationalTricValve, P&F Products & Features, Vienna, AustriaTwo self-expanding bioprostheses: one for IVC and one for SVCRight femoral veinPEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MYXV0ZW48L0F1dGhvcj48WWVhcj4yMDE4PC9ZZWFyPjxS

ZWNOdW0+NDkxPC9SZWNOdW0+PERpc3BsYXlUZXh0PigyMCk8L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+

PHJlYy1udW1iZXI+NDkxPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBk

Yi1pZD0iOXdlZXI1eDBxZHN0MDVldGYyMTV0eHI1emFzdnRydHRzMHo1IiB0aW1lc3RhbXA9IjE1

ODA0NzE2MjUiPjQ5MTwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFs

IEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+TGF1

dGVuLCBBLjwvYXV0aG9yPjxhdXRob3I+RmlndWxsYSwgSC4gUi48L2F1dGhvcj48YXV0aG9yPlVu

YmVoYXVuLCBBLjwvYXV0aG9yPjxhdXRob3I+RmFtLCBOLjwvYXV0aG9yPjxhdXRob3I+U2Nob2Zl

ciwgSi48L2F1dGhvcj48YXV0aG9yPkRvZW5zdCwgVC48L2F1dGhvcj48YXV0aG9yPkhhdXNsZWl0

ZXIsIEouPC9hdXRob3I+PGF1dGhvcj5GcmFueiwgTS48L2F1dGhvcj48YXV0aG9yPkp1bmcsIEMu

PC9hdXRob3I+PGF1dGhvcj5EcmVnZXIsIEguPC9hdXRob3I+PGF1dGhvcj5MZWlzdG5lciwgRC48

L2F1dGhvcj48YXV0aG9yPkFsdXNoaSwgQi48L2F1dGhvcj48YXV0aG9yPlN0dW5kbCwgQS48L2F1

dGhvcj48YXV0aG9yPkxhbmRtZXNzZXIsIFUuPC9hdXRob3I+PGF1dGhvcj5GYWxrLCBWLjwvYXV0

aG9yPjxhdXRob3I+U3RhbmdsLCBLLjwvYXV0aG9yPjxhdXRob3I+TGF1bGUsIE0uPC9hdXRob3I+

PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+RnJvbSB0aGUgQ2hhcml0ZSAt

IFVuaXZlcnNpdGF0c21lZGl6aW4gQmVybGluLCBHZXJtYW55IChBLkwuLCBILkQuLCBELkwuLCBC

LkEuLCBVLkwuLCBLLlMuLCBNLkwuLCBWLkYuKTsgRGV1dHNjaGVzIFplbnRydW0gZnVyIEhlcnot

S3JlaXNsYXVmLUZvcnNjaHVuZyAoRFpISyksIEJlcmxpbiwgR2VybWFueSAoQS5MLiwgSC5ELiwg

RC5MLiwgQi5BLiwgVS5MLiwgSy5TLiwgTS5MLiwgQS5VLiwgVi5GLik7IEZyaWVkcmljaC1TY2hp

bGxlci1Vbml2ZXJzaXRhZXQgSmVuYSwgR2VybWFueSAoSC5SLkYuLCBULkQuLCBNLkYuKTsgRGVw

YXJ0bWVudCBvZiBNZWRpY2luZSBJSSwgSGVhcnQgQ2VudGVyIEJvbm4sIFVuaXZlcnNpdHkgSG9z

cGl0YWwgQm9ubiwgR2VybWFueSAoQS5TLik7IEdlcm1hbiBIZWFydCBDZW50ZXIgQmVybGluIChB

LlUuLCBWLkYuKTsgRGl2aXNpb24gb2YgQ2FyZGlvbG9neSwgU3QuIE1pY2hhZWxzIEhvc3BpdGFs

LCBUb3JvbnRvLCBDYW5hZGEgKE4uRi4pOyBBbGJlcnRpbmVuIEhlYXJ0IENlbnRlciwgSGFtYnVy

ZywgR2VybWFueSAoSi5TLik7IE1lZGl6aW5pc2NoZSBLbGluaWsgdW5kIFBvbGlrbGluaWsgSSwg

THVkd2lnLU1heGltaWxpYW5zLVVuaXZlcnNpdGF0IE11bmNoZW4sIE11bmljaCwgR2VybWFueSAo

Si5ILik7IE1lZGljYWwgRmFjdWx0eSwgRGl2aXNpb24gb2YgQ2FyZGlvbG9neSwgUHVsbW9ub2xv

Z3kgYW5kIFZhc2N1bGFyIE1lZGljaW5lLCBVbml2ZXJzaXR5IER1c3NlbGRvcmYsIEdlcm1hbnkg

KEMuSi4pOyBhbmQgQmVybGluIEluc3RpdHV0ZSBvZiBIZWFsdGgsIEdlcm1hbnkgKFUuTC4pLjwv

YXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkludGVydmVudGlvbmFsIFRyZWF0bWVudCBvZiBT

ZXZlcmUgVHJpY3VzcGlkIFJlZ3VyZ2l0YXRpb246IEVhcmx5IENsaW5pY2FsIEV4cGVyaWVuY2Ug

aW4gYSBNdWx0aWNlbnRlciwgT2JzZXJ2YXRpb25hbCwgRmlyc3QtaW4tTWFuIFN0dWR5PC90aXRs

ZT48c2Vjb25kYXJ5LXRpdGxlPkNpcmMgQ2FyZGlvdmFzYyBJbnRlcnY8L3NlY29uZGFyeS10aXRs

ZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5DaXJjIENhcmRpb3Zhc2MgSW50ZXJ2

PC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48cGFnZXM+ZTAwNjA2MTwvcGFnZXM+PHZvbHVtZT4x

MTwvdm9sdW1lPjxudW1iZXI+MjwvbnVtYmVyPjxlZGl0aW9uPjIwMTgvMDIvMTY8L2VkaXRpb24+

PGtleXdvcmRzPjxrZXl3b3JkPkFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+QWdlZCwgODAgYW5kIG92

ZXI8L2tleXdvcmQ+PGtleXdvcmQ+QmFsbG9vbiBWYWx2dWxvcGxhc3R5PC9rZXl3b3JkPjxrZXl3

b3JkPkJpb3Byb3N0aGVzaXM8L2tleXdvcmQ+PGtleXdvcmQ+Q2FuYWRhPC9rZXl3b3JkPjxrZXl3

b3JkPkNhcmRpYWMgQ2F0aGV0ZXJpemF0aW9uL2FkdmVyc2UgZWZmZWN0cy9pbnN0cnVtZW50YXRp

b24vKm1ldGhvZHMvbW9ydGFsaXR5PC9rZXl3b3JkPjxrZXl3b3JkPkNvbXBhc3Npb25hdGUgVXNl

IFRyaWFsczwva2V5d29yZD48a2V5d29yZD5GZWFzaWJpbGl0eSBTdHVkaWVzPC9rZXl3b3JkPjxr

ZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29yZD5HZXJtYW55PC9rZXl3b3JkPjxrZXl3b3Jk

PkhlYXJ0IFZhbHZlIFByb3N0aGVzaXM8L2tleXdvcmQ+PGtleXdvcmQ+SGVhcnQgVmFsdmUgUHJv

c3RoZXNpcyBJbXBsYW50YXRpb24vYWR2ZXJzZTwva2V5d29yZD48a2V5d29yZD5lZmZlY3RzL2lu

c3RydW1lbnRhdGlvbi8qbWV0aG9kcy9tb3J0YWxpdHk8L2tleXdvcmQ+PGtleXdvcmQ+SGVtb2R5

bmFtaWNzPC9rZXl3b3JkPjxrZXl3b3JkPkhvc3BpdGFsIE1vcnRhbGl0eTwva2V5d29yZD48a2V5

d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48a2V5d29yZD5Qcm9z

dGhlc2lzIERlc2lnbjwva2V5d29yZD48a2V5d29yZD5SZWNvdmVyeSBvZiBGdW5jdGlvbjwva2V5

d29yZD48a2V5d29yZD5SaXNrIEZhY3RvcnM8L2tleXdvcmQ+PGtleXdvcmQ+U2V2ZXJpdHkgb2Yg

SWxsbmVzcyBJbmRleDwva2V5d29yZD48a2V5d29yZD5UaW1lIEZhY3RvcnM8L2tleXdvcmQ+PGtl

eXdvcmQ+VHJlYXRtZW50IE91dGNvbWU8L2tleXdvcmQ+PGtleXdvcmQ+VHJpY3VzcGlkIFZhbHZl

L2RpYWdub3N0aWMgaW1hZ2luZy9waHlzaW9wYXRob2xvZ3kvKnN1cmdlcnk8L2tleXdvcmQ+PGtl

eXdvcmQ+VHJpY3VzcGlkIFZhbHZlIEluc3VmZmljaWVuY3kvZGlhZ25vc3RpYzwva2V5d29yZD48

a2V5d29yZD5pbWFnaW5nL21vcnRhbGl0eS9waHlzaW9wYXRob2xvZ3kvKnN1cmdlcnk8L2tleXdv

cmQ+PGtleXdvcmQ+VmVudHJpY3VsYXIgRnVuY3Rpb24sIFJpZ2h0PC9rZXl3b3JkPjxrZXl3b3Jk

PipoZWFydCB2YWx2ZSBwcm9zdGhlc2lzIGltcGxhbnRhdGlvbjwva2V5d29yZD48a2V5d29yZD4q

aGVtb2R5bmFtaWNzPC9rZXl3b3JkPjxrZXl3b3JkPip0cmljdXNwaWQgcmVndXJnaXRhdGlvbjwv

a2V5d29yZD48a2V5d29yZD4qdHJpY3VzcGlkIHZhbHZlIGluc3VmZmljaWVuY3k8L2tleXdvcmQ+

PGtleXdvcmQ+KnZlbmEgY2F2YSwgc3VwZXJpb3I8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+

PHllYXI+MjAxODwveWVhcj48cHViLWRhdGVzPjxkYXRlPkZlYjwvZGF0ZT48L3B1Yi1kYXRlcz48

L2RhdGVzPjxpc2JuPjE5NDEtNzYzMiAoRWxlY3Ryb25pYykmI3hEOzE5NDEtNzY0MCAoTGlua2lu

Zyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+Mjk0NDUwMDE8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJl

bGF0ZWQtdXJscz48dXJsPmh0dHBzOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzI5NDQ1

MDAxPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4x

MC4xMTYxL0NJUkNJTlRFUlZFTlRJT05TLjExNy4wMDYwNjE8L2VsZWN0cm9uaWMtcmVzb3VyY2Ut

bnVtPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MYXV0ZW48L0F1dGhvcj48WWVhcj4yMDE4PC9ZZWFyPjxS

ZWNOdW0+NDkxPC9SZWNOdW0+PERpc3BsYXlUZXh0PigyMCk8L0Rpc3BsYXlUZXh0PjxyZWNvcmQ+

PHJlYy1udW1iZXI+NDkxPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBk

Yi1pZD0iOXdlZXI1eDBxZHN0MDVldGYyMTV0eHI1emFzdnRydHRzMHo1IiB0aW1lc3RhbXA9IjE1

ODA0NzE2MjUiPjQ5MTwva2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFs

IEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+TGF1

dGVuLCBBLjwvYXV0aG9yPjxhdXRob3I+RmlndWxsYSwgSC4gUi48L2F1dGhvcj48YXV0aG9yPlVu

YmVoYXVuLCBBLjwvYXV0aG9yPjxhdXRob3I+RmFtLCBOLjwvYXV0aG9yPjxhdXRob3I+U2Nob2Zl

ciwgSi48L2F1dGhvcj48YXV0aG9yPkRvZW5zdCwgVC48L2F1dGhvcj48YXV0aG9yPkhhdXNsZWl0

ZXIsIEouPC9hdXRob3I+PGF1dGhvcj5GcmFueiwgTS48L2F1dGhvcj48YXV0aG9yPkp1bmcsIEMu

PC9hdXRob3I+PGF1dGhvcj5EcmVnZXIsIEguPC9hdXRob3I+PGF1dGhvcj5MZWlzdG5lciwgRC48

L2F1dGhvcj48YXV0aG9yPkFsdXNoaSwgQi48L2F1dGhvcj48YXV0aG9yPlN0dW5kbCwgQS48L2F1

dGhvcj48YXV0aG9yPkxhbmRtZXNzZXIsIFUuPC9hdXRob3I+PGF1dGhvcj5GYWxrLCBWLjwvYXV0

aG9yPjxhdXRob3I+U3RhbmdsLCBLLjwvYXV0aG9yPjxhdXRob3I+TGF1bGUsIE0uPC9hdXRob3I+

PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+RnJvbSB0aGUgQ2hhcml0ZSAt

IFVuaXZlcnNpdGF0c21lZGl6aW4gQmVybGluLCBHZXJtYW55IChBLkwuLCBILkQuLCBELkwuLCBC

LkEuLCBVLkwuLCBLLlMuLCBNLkwuLCBWLkYuKTsgRGV1dHNjaGVzIFplbnRydW0gZnVyIEhlcnot

S3JlaXNsYXVmLUZvcnNjaHVuZyAoRFpISyksIEJlcmxpbiwgR2VybWFueSAoQS5MLiwgSC5ELiwg

RC5MLiwgQi5BLiwgVS5MLiwgSy5TLiwgTS5MLiwgQS5VLiwgVi5GLik7IEZyaWVkcmljaC1TY2hp

bGxlci1Vbml2ZXJzaXRhZXQgSmVuYSwgR2VybWFueSAoSC5SLkYuLCBULkQuLCBNLkYuKTsgRGVw

YXJ0bWVudCBvZiBNZWRpY2luZSBJSSwgSGVhcnQgQ2VudGVyIEJvbm4sIFVuaXZlcnNpdHkgSG9z

cGl0YWwgQm9ubiwgR2VybWFueSAoQS5TLik7IEdlcm1hbiBIZWFydCBDZW50ZXIgQmVybGluIChB

LlUuLCBWLkYuKTsgRGl2aXNpb24gb2YgQ2FyZGlvbG9neSwgU3QuIE1pY2hhZWxzIEhvc3BpdGFs

LCBUb3JvbnRvLCBDYW5hZGEgKE4uRi4pOyBBbGJlcnRpbmVuIEhlYXJ0IENlbnRlciwgSGFtYnVy

ZywgR2VybWFueSAoSi5TLik7IE1lZGl6aW5pc2NoZSBLbGluaWsgdW5kIFBvbGlrbGluaWsgSSwg

THVkd2lnLU1heGltaWxpYW5zLVVuaXZlcnNpdGF0IE11bmNoZW4sIE11bmljaCwgR2VybWFueSAo

Si5ILik7IE1lZGljYWwgRmFjdWx0eSwgRGl2aXNpb24gb2YgQ2FyZGlvbG9neSwgUHVsbW9ub2xv

Z3kgYW5kIFZhc2N1bGFyIE1lZGljaW5lLCBVbml2ZXJzaXR5IER1c3NlbGRvcmYsIEdlcm1hbnkg

KEMuSi4pOyBhbmQgQmVybGluIEluc3RpdHV0ZSBvZiBIZWFsdGgsIEdlcm1hbnkgKFUuTC4pLjwv

YXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxlPkludGVydmVudGlvbmFsIFRyZWF0bWVudCBvZiBT

ZXZlcmUgVHJpY3VzcGlkIFJlZ3VyZ2l0YXRpb246IEVhcmx5IENsaW5pY2FsIEV4cGVyaWVuY2Ug

aW4gYSBNdWx0aWNlbnRlciwgT2JzZXJ2YXRpb25hbCwgRmlyc3QtaW4tTWFuIFN0dWR5PC90aXRs

ZT48c2Vjb25kYXJ5LXRpdGxlPkNpcmMgQ2FyZGlvdmFzYyBJbnRlcnY8L3NlY29uZGFyeS10aXRs

ZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5DaXJjIENhcmRpb3Zhc2MgSW50ZXJ2

PC9mdWxsLXRpdGxlPjwvcGVyaW9kaWNhbD48cGFnZXM+ZTAwNjA2MTwvcGFnZXM+PHZvbHVtZT4x

MTwvdm9sdW1lPjxudW1iZXI+MjwvbnVtYmVyPjxlZGl0aW9uPjIwMTgvMDIvMTY8L2VkaXRpb24+

PGtleXdvcmRzPjxrZXl3b3JkPkFnZWQ8L2tleXdvcmQ+PGtleXdvcmQ+QWdlZCwgODAgYW5kIG92

ZXI8L2tleXdvcmQ+PGtleXdvcmQ+QmFsbG9vbiBWYWx2dWxvcGxhc3R5PC9rZXl3b3JkPjxrZXl3

b3JkPkJpb3Byb3N0aGVzaXM8L2tleXdvcmQ+PGtleXdvcmQ+Q2FuYWRhPC9rZXl3b3JkPjxrZXl3

b3JkPkNhcmRpYWMgQ2F0aGV0ZXJpemF0aW9uL2FkdmVyc2UgZWZmZWN0cy9pbnN0cnVtZW50YXRp

b24vKm1ldGhvZHMvbW9ydGFsaXR5PC9rZXl3b3JkPjxrZXl3b3JkPkNvbXBhc3Npb25hdGUgVXNl

IFRyaWFsczwva2V5d29yZD48a2V5d29yZD5GZWFzaWJpbGl0eSBTdHVkaWVzPC9rZXl3b3JkPjxr

ZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29yZD5HZXJtYW55PC9rZXl3b3JkPjxrZXl3b3Jk

PkhlYXJ0IFZhbHZlIFByb3N0aGVzaXM8L2tleXdvcmQ+PGtleXdvcmQ+SGVhcnQgVmFsdmUgUHJv

c3RoZXNpcyBJbXBsYW50YXRpb24vYWR2ZXJzZTwva2V5d29yZD48a2V5d29yZD5lZmZlY3RzL2lu

c3RydW1lbnRhdGlvbi8qbWV0aG9kcy9tb3J0YWxpdHk8L2tleXdvcmQ+PGtleXdvcmQ+SGVtb2R5

bmFtaWNzPC9rZXl3b3JkPjxrZXl3b3JkPkhvc3BpdGFsIE1vcnRhbGl0eTwva2V5d29yZD48a2V5

d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+TWFsZTwva2V5d29yZD48a2V5d29yZD5Qcm9z

dGhlc2lzIERlc2lnbjwva2V5d29yZD48a2V5d29yZD5SZWNvdmVyeSBvZiBGdW5jdGlvbjwva2V5

d29yZD48a2V5d29yZD5SaXNrIEZhY3RvcnM8L2tleXdvcmQ+PGtleXdvcmQ+U2V2ZXJpdHkgb2Yg

SWxsbmVzcyBJbmRleDwva2V5d29yZD48a2V5d29yZD5UaW1lIEZhY3RvcnM8L2tleXdvcmQ+PGtl

eXdvcmQ+VHJlYXRtZW50IE91dGNvbWU8L2tleXdvcmQ+PGtleXdvcmQ+VHJpY3VzcGlkIFZhbHZl

L2RpYWdub3N0aWMgaW1hZ2luZy9waHlzaW9wYXRob2xvZ3kvKnN1cmdlcnk8L2tleXdvcmQ+PGtl

eXdvcmQ+VHJpY3VzcGlkIFZhbHZlIEluc3VmZmljaWVuY3kvZGlhZ25vc3RpYzwva2V5d29yZD48

a2V5d29yZD5pbWFnaW5nL21vcnRhbGl0eS9waHlzaW9wYXRob2xvZ3kvKnN1cmdlcnk8L2tleXdv

cmQ+PGtleXdvcmQ+VmVudHJpY3VsYXIgRnVuY3Rpb24sIFJpZ2h0PC9rZXl3b3JkPjxrZXl3b3Jk

PipoZWFydCB2YWx2ZSBwcm9zdGhlc2lzIGltcGxhbnRhdGlvbjwva2V5d29yZD48a2V5d29yZD4q

aGVtb2R5bmFtaWNzPC9rZXl3b3JkPjxrZXl3b3JkPip0cmljdXNwaWQgcmVndXJnaXRhdGlvbjwv

a2V5d29yZD48a2V5d29yZD4qdHJpY3VzcGlkIHZhbHZlIGluc3VmZmljaWVuY3k8L2tleXdvcmQ+

PGtleXdvcmQ+KnZlbmEgY2F2YSwgc3VwZXJpb3I8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+

PHllYXI+MjAxODwveWVhcj48cHViLWRhdGVzPjxkYXRlPkZlYjwvZGF0ZT48L3B1Yi1kYXRlcz48

L2RhdGVzPjxpc2JuPjE5NDEtNzYzMiAoRWxlY3Ryb25pYykmI3hEOzE5NDEtNzY0MCAoTGlua2lu

Zyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+Mjk0NDUwMDE8L2FjY2Vzc2lvbi1udW0+PHVybHM+PHJl

bGF0ZWQtdXJscz48dXJsPmh0dHBzOi8vd3d3Lm5jYmkubmxtLm5paC5nb3YvcHVibWVkLzI5NDQ1

MDAxPC91cmw+PC9yZWxhdGVkLXVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4x

MC4xMTYxL0NJUkNJTlRFUlZFTlRJT05TLjExNy4wMDYwNjE8L2VsZWN0cm9uaWMtcmVzb3VyY2Ut

bnVtPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+

ADDIN EN.CITE.DATA (20)InvestigationalTricento, New Valve Technology, Muri, SwitzerlandBi-caval stented bioprosthesisTransfemoral ADDIN EN.CITE <EndNote><Cite><Author>Toggweiler</Author><Year>2018</Year><RecNum>492</RecNum><DisplayText>(21)</DisplayText><record><rec-number>492</rec-number><foreign-keys><key app="EN" db-id="9weer5x0qdst05etf215txr5zasvtrtts0z5" timestamp="1580471711">492</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Toggweiler, S.</author><author>De Boeck, B.</author><author>Brinkert, M.</author><author>Buhmann, R.</author><author>Bossard, M.</author><author>Kobza, R.</author><author>Cuculi, F.</author></authors></contributors><auth-address>Heart Center Lucerne, Luzerner Kantonsspital, Lucerne, Switzerland.</auth-address><titles><title>First-in-man implantation of the Tricento transcatheter heart valve for the treatment of severe tricuspid regurgitation</title><secondary-title>EuroIntervention</secondary-title></titles><periodical><full-title>EuroIntervention</full-title></periodical><pages>758-761</pages><volume>14</volume><number>7</number><edition>2018/07/04</edition><keywords><keyword>Aged</keyword><keyword>Cardiac Catheterization</keyword><keyword>Female</keyword><keyword>*Heart Valve Prosthesis</keyword><keyword>*Heart Valve Prosthesis Implantation</keyword><keyword>Humans</keyword><keyword>Prosthesis Design</keyword><keyword>Treatment Outcome</keyword><keyword>*Tricuspid Valve Insufficiency/surgery</keyword></keywords><dates><year>2018</year><pub-dates><date>Sep 20</date></pub-dates></dates><isbn>1969-6213 (Electronic)&#xD;1774-024X (Linking)</isbn><accession-num>29969434</accession-num><urls><related-urls><url>;(21)InvestigationalReferences ADDIN EN.REFLIST 1.Feldman T, Foster E, Glower DD, Kar S, Rinaldi MJ, Fail PS, et al. Percutaneous repair or surgery for mitral regurgitation. N Engl J Med. 2011;364(15):1395-406.2.Obadia JF, Messika-Zeitoun D, Leurent G, Iung B, Bonnet G, Piriou N, et al. Percutaneous Repair or Medical Treatment for Secondary Mitral Regurgitation. N Engl J Med. 2018;379(24):2297-306.3.Stone GW, Lindenfeld J, Abraham WT, Kar S, Lim DS, Mishell JM, et al. Transcatheter Mitral-Valve Repair in Patients with Heart Failure. N Engl J Med. 2018;379(24):2307-18.4.Lim DS, Kar S, Spargias K, Kipperman RM, O'Neill WW, Ng MKC, et al. Transcatheter Valve Repair for Patients With Mitral Regurgitation: 30-Day Results of the CLASP Study. J Am Coll Cardiol Intv 2019;12(14):1369-78.5.Maisano F, Taramasso M, Nickenig G, Hammerstingl C, Vahanian A, Messika-Zeitoun D, et al. Cardioband, a transcatheter surgical-like direct mitral valve annuloplasty system: early results of the feasibility trial. Eur Heart J. 2016;37(10):817-25.6.Rogers JH, Boyd WD, Smith TW, Bolling SF. Early experience with Millipede IRIS transcatheter mitral annuloplasty. Ann Cardiothorac Surg. 2018;7(6):780-6.7.Siminiak T, Wu JC, Haude M, Hoppe UC, Sadowski J, Lipiecki J, et al. Treatment of functional mitral regurgitation by percutaneous annuloplasty: results of the TITAN Trial. Eur J Heart Fail. 2012;14(8):931-8.8.Seeburger J, Rinaldi M, Nielsen SL, Salizzoni S, Lange R, Schoenburg M, et al. Off-pump transapical implantation of artificial neo-chordae to correct mitral regurgitation: the TACT Trial (Transapical Artificial Chordae Tendinae) proof of concept. J Am Coll Cardiol. 2014;63(9):914-9.9.Gammie JS, Bartus K, Gackowski A, D'Ambra MN, Szymanski P, Bilewska A, et al. Beating-Heart Mitral Valve Repair Using a Novel ePTFE Cordal Implantation Device: A Prospective Trial. J Am Coll Cardiol. 2018;71(1):25-36.10.Sorajja P, Moat N, Badhwar V, Walters D, Paone G, Bethea B, et al. Initial Feasibility Study of a New Transcatheter Mitral Prosthesis: The First 100 Patients. J Am Coll Cardiol. 2019;73(11):1250-60.11.Bapat V, Rajagopal V, Meduri C, Farivar RS, Walton A, Duffy SJ, et al. Early Experience With New Transcatheter Mitral Valve Replacement. J Am Coll Cardiol. 2018;71(1):12-21.12.Webb JG, Murdoch DJ, Boone RH, Moss R, Attinger-Toller A, Blanke P, et al. Percutaneous Transcatheter Mitral Valve Replacement: First-in-Human Experience With a New Transseptal System. J Am Coll Cardiol. 2019;73(11):1239-46.13.Verheye S, Cheung A, Leon M, Banai S. The Tiara transcatheter mitral valve implantation system. EuroIntervention. 2015;11 Suppl W:W71-2.14.Barbanti M, Piazza N, Mangiafico S, Buithieu J, Bleiziffer S, Ronsivalle G, et al. Transcatheter Mitral Valve Implantation Using the HighLife System. J Am Coll Cardiol Intv 2017;10(16):1662-70.15.Khan JM, Rogers T, Schenke WH, Greenbaum AB, Babaliaros VC, Paone G, et al. Transcatheter pledget-assisted suture tricuspid annuloplasty (PASTA) to create a double-orifice valve. Catheter Cardiovasc Interv. 2018;92(3):E175-E84.16.Nickenig G, Weber M, Schueler R, Hausleiter J, Nabauer M, von Bardeleben RS, et al. 6-Month Outcomes of Tricuspid Valve Reconstruction for Patients With Severe Tricuspid Regurgitation. J Am Coll Cardiol. 2019;73(15):1905-15.17.Rogers T, Ratnayaka K, Sonmez M, Franson DN, Schenke WH, Mazal JR, et al. Transatrial intrapericardial tricuspid annuloplasty. J Am Coll Cardiol Intv 2015;8(3):483-91.18.Praz F, Spargias K, Chrissoheris M, Bullesfeld L, Nickenig G, Deuschl F, et al. Compassionate use of the PASCAL transcatheter mitral valve repair system for patients with severe mitral regurgitation: a multicentre, prospective, observational, first-in-man study. Lancet. 2017;390(10096):773-80.19.Navia JL, Kapadia S, Elgharably H, Harb SC, Krishnaswamy A, Unai S, et al. First-in-Human Implantations of the NaviGate Bioprosthesis in a Severely Dilated Tricuspid Annulus and in a Failed Tricuspid Annuloplasty Ring. Circ Cardiovasc Interv. 2017;10(12).20.Lauten A, Figulla HR, Unbehaun A, Fam N, Schofer J, Doenst T, et al. Interventional Treatment of Severe Tricuspid Regurgitation: Early Clinical Experience in a Multicenter, Observational, First-in-Man Study. Circ Cardiovasc Interv. 2018;11(2):e006061.21.Toggweiler S, De Boeck B, Brinkert M, Buhmann R, Bossard M, Kobza R, et al. First-in-man implantation of the Tricento transcatheter heart valve for the treatment of severe tricuspid regurgitation. EuroIntervention. 2018;14(7):758-61. ................
................

In order to avoid copyright disputes, this page is only a partial summary.

Google Online Preview   Download