Course Information - Centre for Brain Health



Course InformationCourse TitleCourse Code NumberCredit ValueNeuroscience INRSC 5006.0PrerequisitesRegistration in the Neuroscience graduate program or by permission from the course coordinator.Contacts If required, please contact via email to arrange a time to meet and discuss any issues or questions pertaining to course content. All other instructional staffs’ contact information will be made available during their respective lecture(s). Course Instructor(s) & Instructional StaffContact DetailsDr. Tim Murphy (Course Coordinator; Module 2 Leader)timothy.murphy@ubc.caDr. Lynn Raymond (Module 1 Leader)lynn.raymond@ubc.caDr. Brian MacVicar (Module 1 Leader)brian.macvicar@ubc.ca Dr. Ann Marie Craig (Module 2 Leader)annmarie.craig@ubc.caDr. Steven Vincent (Module 3 Leader)steven.vincent@ubc.caDr. Timothy O’Connor (Module 4 Leader)timothy.oconnor@ubc.caYundi Wang (TA)yundi.wang@alumni.ubc.ca Allen Yang (Neuroscience Program Coordinator)ubc.neuroscience@ubc.ca If you do not have access to Canvas, please email the Neuroscience Program Coordinator.Course StructureThis course focuses on the study of Neuroscience at the molecular and cellular level, including systemic and behavioral approaches to studying the nervous system. This course is divided into four modules: (1) The Biophysics of Ion Channels, (2) Synaptic Transmission and Ligand-Gated Ion Channels, (3) Second Messengers and Gene Expression, and (4) Development.Unless otherwise noted, all classes will be held in Conference Room 3402A/B in the Djavad Mowafaghian Centre for Brain Health on Mondays, Wednesdays and Fridays 8:30-10:30am Major Dates 2019:Class starts Sept. 4th 2019 Module #1 Problem SetSept. 25th 2019Module #2 Presentations Oct. 16, 2019SFN Oct. 19th-23rd 2019Midterm ExamOct. 25th 2019Module #3 Presentations Oct. 28th 2019CIHR ApprovalOct. 28th 2019CIHR Summary/PresentationNov. 8th 2019Module #4 Presentations Dec. 4th 2019Final Exam Dec 11th 2019Final CIHR Proposal Dec 18th 2019Schedule of TopicsThe following is a provisional schedule. Please keep in mind that some minor changes may occur: DateLecture Topic & Exam/Assignment Due DatesWed Sep 4, 2019 Program Introduction & Meet and GreetDr. Liisa Galea & Allen YangCell Biology of the Neuron & Course BackgroundDr. Tim Murphy Fri Sep 6, 2019 Neuroscience Software Resources Jeff LeDue, Glaynel Alejo & Dr. Tim MurphyMon Sep 9 , 2019 Start of Module 1 Ion channels and excitable membranes (7 lectures)Resting Membrane Potential Dr. Lynn RaymondWed Sep 11, 2019 Molecular Biology of Voltage- & Ligand-Gated Ion ChannelsDr. Nick WeilingerFri Sep 13, 2019 Calcium ChannelsDr. Terry SnutchMon Sep 16, 2019 Action Potential I: Conduction and Cable PropertiesDr. Jeremy Seamans Wed Sep 18, 2019 Action Potential II: Sodium and Potassium Conductances Dr. Jeremy Seamans Fri Sep 20, 2019 Potassium channels Dr. Brian MacVicar Mon Sep 23, 2019 Molecular Approaches in NeurobiologyDr. Ann Marie CraigWed Sep 25, 2019 Module 1 Review Session Dr. Lynn Raymond & Dr. Brian MacVicar***MODULE 1 PROBLEM SET DUE***Fri Sep 27, 2019 Start of Module 2 Synaptic transmission (7 lectures)Neurochemistry I: Amino Acid and peptide synthesis and degradationDr. Tim MurphyMon Sep 30, 2019 Intro to MicroscopyDr. Kurt HaasWed Oct 2, 2019 Ligand-Gated Ion Channels IDr. Ann-Marie CraigFri Oct 4, 2019 Ligand-Gated Ion Channels IIDr. Ann-Marie CraigMon Oct 7, 2019Neurochemistry II: Amine synthesis and degradationDr. Steven VincentWed Oct 9, 2019 Synaptic Transmission I: Ionic properties of neurotransmitter releaseDr. Tim MurphyFri Oct 11, 2019 Synaptic Transmission II: Molecular properties of transmitter releaseDr. Tim MurphyMon Oct 14, 2019 Thanksgiving; NO CLASSES Wed Oct 16, 2019 Student Presentations Dr. Anne Marie Craig & Dr. Tim Murphy***MODULE 2 CRITIQUE DUE & MODULE 2 PRESENTATION DATE***Fri Oct 18, 2019Module 2 Review SessionDr. Anne Marie Craig & Dr. Tim MurphyMon-Wed Oct 21-23, 2019 Society for Neuroscience Annual Meeting; NO CLASSESFri Oct 25, 2019 ***Midterm Exam – Modules 1 and 2 (8:30am-12:30pm)*** Mon Oct 28, 2019 Start of Module 3 Signal transduction, gene expression, and genomics (8 lectures)Second Messengers: cyclic nucleotides (cAMP, cGMP, nitric oxide)Dr. Steven Vincent***CIHR PROPOSAL APPROVAL DUE at 9am (Supervisor + Title)***Wed Oct 30, 2019 Second Messengers: Calcium and IP3; Non-selective Cation ChannelsDr. Brian MacVicarMon Nov 1, 2019 Receptor RegulationDr. Lynn Raymond & Dr. Steven VincentFri Nov 4, 2019 Optogenetics and ChemogeneticsDr. Tim MurphyWed Nov 6, 2019Lipid and Lipoproteins in the CNSDr. Cheryl WellingtonFri Nov 8, 2019 ***CIHR SUMMARY DUE & CIHR PRESENTATION DATE***All Module Leaders will be presentMon Nov 11, 2019Remembrance Day; NO CLASSES Wed Nov 13, 2019 Regulation of Neuronal Gene ExpressionDr. Weihong SongFri Nov 15, 2019 Epigenetic Variation in Human Health and DiseaseDr. Cierna Vogel Mon Nov 18, 2019 Genetic Resources and ApproachesDr. Paul PavlidisWed Nov 20, 2019 Student Presentations Dr. Steven Vincent ***MODULE 3 CRITIQUE DUE & MODULE 3 PRESENTATION DATE***Fri Nov 22, 2019 Start of module 4 Development (5 lectures)Nervous System Induction and Regional DifferentiationDr. Tim O’ConnorMon Nov 25, 2019 Proces Outgrowth and Neural PathfindingDr. Tim O’ConnorWed Nov 27, 2019 SynaptogenesisDr. Kurt HaasFri Nov 29, 2019 Activitiy and Circuit FormationDr. Kurt HaasMon Dec 2, 2019 Neurite Elimination and Cell Death Dr. Shernaz BamjiWed Dec 4, 2019 Student Presentations Dr. Tim O’Connor ***MODULE 4 CRITIQUE DUE & MODULE 4 PRESENTATION DATE***Wed Dec 11, 2019 ***Final Exam – Modules 3 and 4 (8:30am-12:30pm)***Wed Dec 18, 2019***FINAL CIHR PROPOSAL DUE at 4pm***Learning OutcomesModule 1 Specific Topics:Module 2 Specific Topics:Matlab/PythonMolecular biology of voltage and ligand-gated ion channelsResting Membrane PotentialVoltage and current clamp techniques, pitfalls and neuronal modelling Action potential (conduction & cable properties, sodium and potassium conductances)Voltage-gated ion channelsMolecular methodsNeurochemistry (amino acid/peptide/amine synthesis and degradation)Synaptic transmission, molecular properties of transmitter releaseLigand-gated ion channelsModule 3 Specific Topics:Module 4 Specific Topics:Cyclic nucleotidesLipids and lipid proteins in the CNSOpto and chemogeneticsReceptor regulationGenetic resources and approachesPrions and protein folding & misfoldingCalcium and IP3Non-selective cation channelsEpigenetic variation in human health and diseaseControl of neural gene expressionNervous system inductionProliferation and differentiationProcess outgrowth and neural pathfindingSynaptogenesisActivity and circuit formationCell death in the nervous systemBeyond gaining an understanding of the specific topics listed above for each module, by the end of this course, students will also be able to:Write and present a CIHR grant proposal:Search current literature, evaluate the existing evidence, propose an overarching problem to be investigated and provide rationale for the proposed researchFormulate strong, focused, well-supported and testable research questions/hypotheses and propose methods to test the hypotheses in a framework of several specific aimsClearly define expected results and potential pitfalls of proposed methods/research designDeliver a critique presentation and write written critiques on an assigned paper:Concisely describe the overarching experimental problems, hypotheses, methods and results of the assigned paperCritically evaluate the appropriateness, strengths/limitations of various methods, results and research designs Based on other existing evidence propose potential future directions Learning ActivitiesStudents will be expected to:Complete a problem set assignment individually in Module 1Present and write a written critique for either Module 2, 3 or 4. Paper critique assignments will be assigned at the start of each respective moduleChose a module and write a CIHR proposal, summary and present their CIHR proposal on a topic selected by the student. Topics must fall under one of the modules and be approved by the appropriate Module LeaderWrite both a closed book midterm and final exam which cover Modules 1 & 2 and Modules 3 & 4, respectively. The final exam is NOT cumulative. Exams consist of a series of short answer questions. All critique assignments, lecture handouts and other documents will be uploaded on Canvas when they become available. For details pertaining to each lecture (i.e. aims, topics, etc.) please check the calender on Canvas. Unless otherwise noted, all assignments are to be handed in on Canvas. If you do not have access to Canvas, please email the Neuroscience Program Coordinator: Allen Yang (ubc.neuroscience@ubc.ca ).Recommended Textbooks/Readings:Other recommended papers and readings will be made available on Canvas. The following are recommended textbooks which can be purchased through the UBC Bookstore: Principles of Neural Science – Eric R. Kandel Ionic Channels of Excitable Membranes - Bertil Hille Molecular Biology of the Cell – Bruce Alberts Assessments of LearningA student’s final grade for the course is the sum of the separate assignments and exams. It is not necessary to pass each assignment and exam separately in order to pass the course. In determining the overall grade in the course the following weights will be used:Module 1 Problem Set6%Written Critique6%Oral Critique Presentation6%CIHR Proposal Approval1%CIHR Summary6%CIHR Presentation6%Final CIHR Proposal29%Midterm20%Final Exam20%***Re-grading of marked work will be at the discression of the appropriate course instructor(s). The Course Coodrinator may be contacted if any issues arise***Missed Components of Term Work:Late assignments will lose 5% per day late past the deadline for all assignments or as specified in Canvas. Assignments will NOT be accepted more than 3 days after the posted deadline and students failing to submit any assignment within this time frame will receive a mark of zero. With the exception of emergencies or other extenuating circumstances (as deemed appropriate by the Course Coordinator and Module Leaders), students who miss a presentation or exam will receive a mark of zero unless the instructors have been previously notified. There will be NO exceptions to this policy. Again, with the exception of emergencies or other extenuating circumstances (as deemed appropriate by the Course Coordinator and Module Leaders) extensions on any assignments or exams will NOT be granted. Please be advised that students should notify the appropriate instructors before the assignment and/or exam deadline to discuss this. Where applicable, appropriate new assessment and assignment deadlines and make-up exams will be arranged accordingly. Grading Scheme:A+ 90-100%B+ 76-79%C+ 64-67%D+ 50-54%A 85-89%B 72-75%C 60-63%F 0-49% (FAIL)A- 80-84%B- 68-71%C- 55-59%*** Students who fail to achieve a mark of 80% or higher in NRSC 500 will be required to answer questions regarding NRSC 500 at their comprehensive examinations. ***University PoliciesUBC provides resources to support student learning and to maintain healthy lifestyles but recognizes that sometimes crises arise and so there are additional resources to access including those for survivors of sexual violence. UBC values respect for the person and ideas of all members of the academic community. Harassment and discrimination are not tolerated nor is suppression of academic freedom. UBC provides appropriate accommodation for students with disabilities and for religious observances. UBC values academic honesty and students are expected to acknowledge the ideas generated by others and to uphold the highest academic standards in all of their actions. Details of the policies and how to access support are available here ().CopyrightAll materials of this course (course handouts, lecture slides, assessments, course readings, etc.) are the intellectual property of the Course Instructor or licensed to be used in this course by the copyright owner. Redistribution of these materials by any means without permission of the copyright holder(s) constitutes a breach of copyright and may lead to academic discipline. ................
................

In order to avoid copyright disputes, this page is only a partial summary.

Google Online Preview   Download