Single Patient IND



Ifosfamide

FDA Approved

Risks Associated with Ifosfamide

Frequent (Between a 10-50% chance that this will happen)

• A low number of white blood cells may increase the risk of infection. It may become life-threatening. Symptoms of infection may include fever, pain, redness, and/or difficulty breathing.

• Blood in the urine

• Low number of red blood cells that can causes tiredness and shortness of breath. May require a blood transfusion.

• Hairloss

• Feeling sick to the stomach

• Vomiting

Occasional (Between a 1-10% chance that this will happen)

• Kidney failure, which is when both of your kidneys fail and your body holds fluid which can be serious or life threatening. Your blood pressure rises and harmful wastes build up in your body. You may experience fatigue, nausea, and loss of appetite. When this happens, you need treatment to replace the work of your failed kidneys such as dialysis.

• Any change from the normal heartbeat (abnormal heartbeat)

• Confusion

• Feeling tired, tiredness, weakness.

• Fluid in the lungs which can cause shortness of breath. If severe, it may require hospitalization and treatment. It can be serious or life threatening.

• Low number of platelets, which may cause bleeding and bruising. Bleeding may be serious or life threatening and may required a blood transfusion.

• Inability to have children

Rare (Less than a 1% chance that this will happen)

• The heart is not able to pump blood properly, which can cause weakness and tiredness, fluid retention, and fluid build-up in the lungs, which can cause shortness of breath.

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DANA-FARBER / HARVARD CANCER CENTER

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