The Renal Drug Handbook.
1
The following references were used in compiling these monographs: Fink, Mitchell et al. Textbook of Critical Care. 5th edition 2005 Ashley, Caroline and Currie, Aileen. The Renal Drug Handbook. 2nd ed. United
Kingdom: Radcliffe Medical Press Ltd, 2004 Shann, Frank. Drug Doses. 14th ed. Intensive Care Unit. Royal Children's
Hospital, Parkville, Victoria 3052, Australia, 2008 McClintock, Alan et al. Notes on Injectable Drugs. 5th ed. New Zealand. New
Zealand Healthcare Pharmacists' Association, 2004 Medsafe Drug Data sheets (New Zealand Medicine and Medical Devices Safety
Authority): MIMS Gateway:
An online version of this drug manual, optimised for smartphone & tablet viewing, is available at: An offline version is available for download (as a PDF) from: The most up-to-date version of this drug manual will always be available online. Should any discrepancies exist between the printed & online versions, the latter should always take precedence.
2
Preface
The first edition of the Intensive Care Drug Manual was developed by Dr. Paul Young for use in the Intensive Care Unit in Wellington Regional Hospital in 2011.
This third edition has been updated for 2020 with revisions reflecting changes in our unit's Intensive Care practice and the ever-evolving critical care literature.
On occasion, doses, methods of administration and indications differ from those available given in the product information. In such cases, recommendations reflect common ICU practice both here and elsewhere.
All doses have been checked independently by two Intensive Care Specialists. However if you suspect an error, please check data with alternative sources and notify the editor.
Clinical responsibility for the choice, dose, route & frequency of any medication always remains with the prescribing doctor. This manual is for use in a monitored critical care environment only.
Specific changes for this third edition
include: ? New entries for levetiracetam, mannitol
& tranexamic acid. ? Updated & expanded appendices
providing more information on common drug-related queries. ? New appendices on drug cost by administration route, intravenous to oral antibiotic SWITCH, and local anaesthetic toxicity. ? Vancomycin dosage & monitoring has been changed extensively. ? All drug prices have been updated as of August 2017 and are quoted are in New Zealand dollars.
Prices have been included to inform prescribing choices where intravenous or enteral routes of administration are equivocal. For example, the intravenous preparation of Acetazolamide costs 250 times that of a single tablet (bioavailability >90%).
Alex Psirides Wellington, New Zealand
August 2020
e: alex.psirides@.nz w: t: @psirides
This document (c) 2020 Wellington ICU. It cannot be sold or altered without permission of the author. It is made freely available in keeping with the principles of Free Open Access to Medical Education (FOAMEd)
3
TABLE OF CONTENTS
A
Acetazolamide
7
Acetylcysteine
9
Acyclovir
11
Adenosine
14
Adrenaline
17
Allopurinol
20
Aminophylline
23
Amiodarone
26
Amitriptylline
29
Amlodipine
31
Amoxicillin /Amoxycillin 33
Amoxicillin-Clavulanic
Acid
36
Amophtericin B
(Liposomal)
39
Aspirin
42
Atenolol
44
Atorvastatin
46
Atracurium
48
Atropine
50
Azathioprine
52
B
Bendrofluazide
55
Benzylpenicillin /
Penicillin G
57
C
Caffeine
60
Calcitriol
62
Calcium Carbonate
64
Calcium Chloride
66
Calcium Gluconate
68
Candesartan
70
Captopril
72
Carbamazepine
75
Carvedilol
79
Caspofungin
82
Cefaclor
85
Cefazolin / Cephazolin 88
Cefotaxime
91
Ceftazidime
94
Ceftriaxone
97
Cefuroxime
100
Celiprolol
104
Charcoal (Activated) 106
Chloral Hydrate
108
Chlorpromazine
110
Cilazapril
113
Ciprofloxacin
116
Citalopram
120
Clarithromycin
122
Clindamycin
125
Clonazepam
128
Clonidine
131
Clopidogrel
133
Clozapine
135
Codeine Phosphate
138
Colchicine
140
Coloxyl with Senna
142
Co-trimoxazole
143
Cyclizine
147
Cyclosporin
149
D
Dantrolene
154
Desmopressin / DDAVP 156
Dexamethasone
158
Dexmedetomidine
161
Diazepam
164
Diclofenac Sodium
167
Digoxin
171
Diltiazem
175
Dipyridamole
178
Dobutamine
180
Dopamine
182
Doxazosin
185
E
Enalapril
187
Enoxaparin
190
Ephedrine
194
Erythromycin
196
Esmolol
199
Etomidate
201
4
F
Felodipine
203
Fentanyl
205
Flucloxacillin
207
Fluconazole
210
Flumazenil
213
Fluoxetine
215
Frusemide
217
G
Gabapentin
220
Ganciclovir
222
Gentamicin
224
Glucagon
227
Glyceryl Trinitrate
229
Glycopyrrolate
231
H
Haloperidol
233
Heparin
236
Hydralazine
239
Hydrocortisone
241
Hyoscine Butylbromide 244
Hyoscine Hydrobromide 246
I
Ibuprofen
248
Iloprost
251
Imipenem
254
Ipratropium Bromide 257
Isoprenaline
259
K
Ketamine
261
L
Labetalol
263
Lactulose
266
Levetiracetam
268
Levosimendan
271
Lithium
274
Loperamide
277
Losartan
279
M
Magnesium Sulphate 281
Mannitol
284
Meropenem
287
Metaraminol
290
Metformin
292
Methylene Blue
294
Methylprednisolone 296
Metoclopramide
299
Metoprolol
302
Metronidazole
304
Midazolam
307
Milrinone
310
Morphine Sulphate &
Morphine Tartrate
312
Moxifloxacin
315
N
Naloxone
318
Neostigmine
320
Nicotine
322
Nimodipine
324
Noradrenaline
326
O
Octreotide
328
Olanzapine
330
Omeprazole
332
Ondansetron
334
Oxycodone
336
5
TABLE OF CONTENTS
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