The Renal Drug Handbook.

1

The following references were used in compiling these monographs: Fink, Mitchell et al. Textbook of Critical Care. 5th edition 2005 Ashley, Caroline and Currie, Aileen. The Renal Drug Handbook. 2nd ed. United

Kingdom: Radcliffe Medical Press Ltd, 2004 Shann, Frank. Drug Doses. 14th ed. Intensive Care Unit. Royal Children's

Hospital, Parkville, Victoria 3052, Australia, 2008 McClintock, Alan et al. Notes on Injectable Drugs. 5th ed. New Zealand. New

Zealand Healthcare Pharmacists' Association, 2004 Medsafe Drug Data sheets (New Zealand Medicine and Medical Devices Safety

Authority): MIMS Gateway:

An online version of this drug manual, optimised for smartphone & tablet viewing, is available at: An offline version is available for download (as a PDF) from: The most up-to-date version of this drug manual will always be available online. Should any discrepancies exist between the printed & online versions, the latter should always take precedence.

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Preface

The first edition of the Intensive Care Drug Manual was developed by Dr. Paul Young for use in the Intensive Care Unit in Wellington Regional Hospital in 2011.

This third edition has been updated for 2020 with revisions reflecting changes in our unit's Intensive Care practice and the ever-evolving critical care literature.

On occasion, doses, methods of administration and indications differ from those available given in the product information. In such cases, recommendations reflect common ICU practice both here and elsewhere.

All doses have been checked independently by two Intensive Care Specialists. However if you suspect an error, please check data with alternative sources and notify the editor.

Clinical responsibility for the choice, dose, route & frequency of any medication always remains with the prescribing doctor. This manual is for use in a monitored critical care environment only.

Specific changes for this third edition

include: ? New entries for levetiracetam, mannitol

& tranexamic acid. ? Updated & expanded appendices

providing more information on common drug-related queries. ? New appendices on drug cost by administration route, intravenous to oral antibiotic SWITCH, and local anaesthetic toxicity. ? Vancomycin dosage & monitoring has been changed extensively. ? All drug prices have been updated as of August 2017 and are quoted are in New Zealand dollars.

Prices have been included to inform prescribing choices where intravenous or enteral routes of administration are equivocal. For example, the intravenous preparation of Acetazolamide costs 250 times that of a single tablet (bioavailability >90%).

Alex Psirides Wellington, New Zealand

August 2020

e: alex.psirides@.nz w: t: @psirides

This document (c) 2020 Wellington ICU. It cannot be sold or altered without permission of the author. It is made freely available in keeping with the principles of Free Open Access to Medical Education (FOAMEd)

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TABLE OF CONTENTS

A

Acetazolamide

7

Acetylcysteine

9

Acyclovir

11

Adenosine

14

Adrenaline

17

Allopurinol

20

Aminophylline

23

Amiodarone

26

Amitriptylline

29

Amlodipine

31

Amoxicillin /Amoxycillin 33

Amoxicillin-Clavulanic

Acid

36

Amophtericin B

(Liposomal)

39

Aspirin

42

Atenolol

44

Atorvastatin

46

Atracurium

48

Atropine

50

Azathioprine

52

B

Bendrofluazide

55

Benzylpenicillin /

Penicillin G

57

C

Caffeine

60

Calcitriol

62

Calcium Carbonate

64

Calcium Chloride

66

Calcium Gluconate

68

Candesartan

70

Captopril

72

Carbamazepine

75

Carvedilol

79

Caspofungin

82

Cefaclor

85

Cefazolin / Cephazolin 88

Cefotaxime

91

Ceftazidime

94

Ceftriaxone

97

Cefuroxime

100

Celiprolol

104

Charcoal (Activated) 106

Chloral Hydrate

108

Chlorpromazine

110

Cilazapril

113

Ciprofloxacin

116

Citalopram

120

Clarithromycin

122

Clindamycin

125

Clonazepam

128

Clonidine

131

Clopidogrel

133

Clozapine

135

Codeine Phosphate

138

Colchicine

140

Coloxyl with Senna

142

Co-trimoxazole

143

Cyclizine

147

Cyclosporin

149

D

Dantrolene

154

Desmopressin / DDAVP 156

Dexamethasone

158

Dexmedetomidine

161

Diazepam

164

Diclofenac Sodium

167

Digoxin

171

Diltiazem

175

Dipyridamole

178

Dobutamine

180

Dopamine

182

Doxazosin

185

E

Enalapril

187

Enoxaparin

190

Ephedrine

194

Erythromycin

196

Esmolol

199

Etomidate

201

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F

Felodipine

203

Fentanyl

205

Flucloxacillin

207

Fluconazole

210

Flumazenil

213

Fluoxetine

215

Frusemide

217

G

Gabapentin

220

Ganciclovir

222

Gentamicin

224

Glucagon

227

Glyceryl Trinitrate

229

Glycopyrrolate

231

H

Haloperidol

233

Heparin

236

Hydralazine

239

Hydrocortisone

241

Hyoscine Butylbromide 244

Hyoscine Hydrobromide 246

I

Ibuprofen

248

Iloprost

251

Imipenem

254

Ipratropium Bromide 257

Isoprenaline

259

K

Ketamine

261

L

Labetalol

263

Lactulose

266

Levetiracetam

268

Levosimendan

271

Lithium

274

Loperamide

277

Losartan

279

M

Magnesium Sulphate 281

Mannitol

284

Meropenem

287

Metaraminol

290

Metformin

292

Methylene Blue

294

Methylprednisolone 296

Metoclopramide

299

Metoprolol

302

Metronidazole

304

Midazolam

307

Milrinone

310

Morphine Sulphate &

Morphine Tartrate

312

Moxifloxacin

315

N

Naloxone

318

Neostigmine

320

Nicotine

322

Nimodipine

324

Noradrenaline

326

O

Octreotide

328

Olanzapine

330

Omeprazole

332

Ondansetron

334

Oxycodone

336

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TABLE OF CONTENTS

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