University of Notre Dame



Protein SynthesisTeacher Notes: The intent of this activity is that the student will go through a process simulating proteins synthesis. (Transcription and translation) The end result is a key chain which represents a protein.1. Print 2 DNA template pages. Use one to make the key - color each amino acid with the correct bead color. This will give the teacher a quick reference to see if translation is correct when the student brings the teacher the worksheet and key chain. 2.. Cut out each individual strand of DNA.3. Designate an area of the teacherr room to represent the nucleus (where the DNA templates can be found). I use the front of my room and tape the DNA templates on the board.4. Handout Protein Synthesis lab worksheet to students.5. Assign students a number (1-24). This will be the DNA template for them to use to build the key chain.6. Students bring worksheet to DNA located in the nucleus. Students may not leave the nucleus as they transcribe the DNA template to mRNA.7. The mRNA (written on the worksheet) may leave the nucleus and head to the ribosomes (desk) and then translation may begin. (students will need a codon table or circle)8. Once translation is complete - students can start building the protein.9. As students begin to build - have a colored pencil matching the color of the bead and have students color that block of the mRNA.10. Before the teacher ties off the end of the protein - make sure the beads are correct (compare to the teacher key made in #1) - if not correct - send student back to correct the sequence of amino acids.Materials: I use pony beads from any craft store or Wal-Mart - just make sure the teacher have 20 different colors. Key chain holders can also be purchased at the craft stores. Floral wire may be used to build the key chain - I use stretchy plastic line and cut it long enough for students to add beads. (I think all the templates code for about 11 amino acids) In order to finish, students bring the completed key chain to the teacher. The teacher then is responsible for finishing the key chain. ................
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