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161SxDxSpecific?Morning stiffness, better w exercise, ulnar deviationRheumatoid arthritisAnti-RF (sensitive), Anti-CCP (specific)?Malar rashLupusANA (sensitive), Anti-smith, anti-dsDNA (specific)Ab can cause 3rd degree heart block by crossing placentaAutoimmune hemolytic anemia Lupus ??Pregnant woman w size less than dates, recurrent pregnancy lossesAnti-phospholipid antibody syndromeAnti-phospholipid, anti-cardiolipin, lupus anticoag, anti-beta2-glycoprotein?Marital problems d/t pain w sexual intercourse, dry mouthSjogren's Anti-ro (SSA), anti-la (SSB)Ab can cause 3rd degree heart block by crossing placenta!?Wegner'sc-ANCA??Ulcerative colitis, PSC, polyarteritis nodosa, Churg-Strauss/EGPA, microscopic polyangiitisp-ANCA?Prox muscle, shoulder weakness; elevated CKPolymyositis, dermatomyositisAnti-Jo1 (--| tRNA synthetase), anti-mi2, anti-SRP?Bleeding gums, plt >20,000ITPAnti-Gp2b3a Vs. Glanzmann (complete deficiency of Gp2b3a)45F, jaundice, pruritus, conjugated hyperbili Primary biliary cholangitisAnti-mitochondrial ??Systemic sclerodermaAnti-Scl70/topoisomerase ??CREST Anti-centromerecalcinosis + Raynaud + esophageal + sclerodactyly + telangiectasiaTB tx with new malar rashDrug-induced lupus ?Anti-histone Sulfonamides, etanercept, procainamide, hydralazine, isoniazid ?Mixed-connective tissue diseaseAnti-U1RNP??Post-infectious glomerulonephritisAnti-streptolysin O, anti-DNAse B?17Y w/ diabetesT1DMAnti-islet cell antibodies = GAD, IA2?Hypothyroidism Hashimoto's Anti-thyroglobulin, anti-TPO*MCC of hypothyroidism in USHyperthyroidGravesThyroid-stimulating immunoglobulin?40F, Droopy eyesMyasthenia gravisAnti-nicotinic ach receptor??Hemolytic disease of newbornAnti-Rh, anti-Kell?Encephalitis, post URI/vaccine/VZVAutoimmune encephalitisAnti-NMDA?H/o breast cancer, ataxiaLimbic encephalitisAnti-Hu, anti-Yo??Autoimmune hepatitisType 1: anti-smooth muscle; Type 2: anti-liver/kidney/microsomal "lupoid-hepatitis"Painful vision loss that resolves after few weeks, lose all sensation below T4/T10Neuromyelitis optica/Devic's diseaseAnti-NMOMS-variantHematuria, hemoptysisGoodpasture syndromeAnti-GBM??Pemphigus vulgarisAnti-desmoglein (desmosomes)??Bullous pemphigoidAnti-hemi-desmosomesLess dangerous than pemphigus, nikolsky-negative Fat malabsorption, low weight, rash on extensor surfaces of upper/lower extremities w/o silver scaleCeliac diseaseAnti-gliadin, anti-TTG, anti-endomysial ?Smoked for long time, trouble rising from a charLambert-Eaton syndromeAnti-presynaptic voltage gated Ca channel?Loss of LE vibratory sensation, Babinski+, (UMN + LMN sx)B12 deficiency 2/2 pernicious anemiaAnti-IF (parietal cells)??SxDxHLA??Seronegative spondyloarthropathyHLA-B27?Recent HIV tx, profound anaphylaxis + death!Abacavir-anaphylaxisHLA-B57?Iran, painful sores on buccal mucosaBehcet's disease HLA-B51Dx: pathergy test ................
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