Lung Cancer and Paraneoplastic Syndromes
[Pages:62]Lung Cancer and Paraneoplastic Syndromes
Amita Vasoya D.O. FACOI, FCCP, FAASM Christiana Care Pulmonary Associates Clinical Assistant Professor of Medicine Sidney Kimmel Medical College of Thomas Jefferson University Rowan University School of Osteopathic Medicine ACOI Board Review 2019
Disclosures
None
Introduction
Lung cancer is the most common cause of mortality WORLDWIDE
1.3 million deaths per year
In U.S. 2012: 226,000 new cases
American Cancer Society Facts & Figures 2012
5 year Survival Rates
National Cancer Institute 2008
Risk Factors
SMOKING Environmental
Radon Air pollution Metals
Asbestos Genetics HIV Pulmonary Fibrosis Radiation therapy
Benign Lung Neoplasms
Epithelial Derived
Papilloma (smoking, HPV)
Smoking, HPV Squamous cell cancer
Micronodular Pneumocyte Hyperplasia
Tuberous sclerosis and/or LAM
Nonepithelial Derived
Hamartoma
50% of benign lung tumors
Solitary fibrous tumor
Malignant Lung Neoplasms
Non-small cell lung cancer (NSCLC)-most common
Squamous cell Adenocarcinoma-most common
"bronchoalveolar cell"
Atypical adenomatous hyperplasia, adenocarcinoma in-situ, minimally invasic adenocarcinoma
Large cell Carcinoid
Small cell lung cancer (SCLC)
Classic, large cell neuroendocrine, combined Limited or Extensive
Primary pulmonary lymphoma
Mucosa-associated lymphoid tissue type Lymphomatoid granulomatosis
ATS Pulmonary Board Review 2015
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