Possible Side Effects of Cyclophosphamide, Cytarabine IV ...



Possible Side Effects of Cyclophosphamide, Cytarabine IV or SQ; IT Methotrexate, Mercaptopurine (MP), Vincristine, and PEG L-asparaginase (Table Version Date: August 28, 2014)

|COMMON, SOME MAY BE SERIOUS |

|In 100 people receiving Cyclophosphamide, Cytarabine IV or SQ; IT Methotrexate, Mercaptopurine (MP), Vincristine, and PEG L-asparaginase, more than 20 and up |

|to 100 may have: |

|Hair loss |

|Diarrhea, constipation, nausea, vomiting, loss of appetite |

|Infection, especially when white blood cell count is low |

|Absence of menstrual period which may decrease the ability to have children |

|Blood in urine |

|Blood clot |

|Swelling and sores in the rectum which may cause rectal pain |

|Sores in mouth which may cause difficulty swallowing |

|Anemia which may cause tiredness, or may require blood transfusions |

|Fever |

|Damage to the liver which may cause belly pain, bleeding, yellowing of skin or eyes |

|Fatigue |

|Pain or redness at the site of injection |

|Numbness and tingling of fingers or toes |

|Headache, jaw pain and/or muscle pain |

|Weakness and difficulty walking |

|Chills |

|Pain |

|Swelling of the body |

|Blockage of the airway which may cause cough, wheezing |

|Hives, rash |

|OCCASIONAL, SOME MAY BE SERIOUS |

|In 100 people receiving Cyclophosphamide, Cytarabine IV or SQ; IT Methotrexate, Mercaptopurine (MP), Vincristine, and PEG L-asparaginase, from 4 to 20 may |

|have: |

|Damage to the bone marrow (irreversible) which may cause infection, bleeding, may require transfusions |

|Loss or absence of sperm which may lead to an inability to father children |

|Stuffy nose |

|Fluid around the heart |

|Bruising, bleeding |

|Allergic reaction which may cause rash, low blood pressure, wheezing, shortness of breath, swelling of the face or throat |

|Numbness and tingling of the arms and legs |

|Severe blood infection |

|Kidney damage which may cause swelling, may require dialysis |

|Chest pain |

|Swelling and redness of the eye |

|Drooping eyelids |

|Sores in stomach |

|Hoarseness |

|Abnormal heart beat |

|Night sweats |

|RARE, AND SERIOUS |

|In 100 people receiving Cyclophosphamide, Cytarabine IV or SQ; IT Methotrexate, Mercaptopurine (MP), Vincristine, and PEG L-asparaginase, 3 or fewer may have: |

|Severe skin rash with blisters and peeling which can involve mouth and other parts of the body |

|Damage to the heart or heart failure which may cause shortness of breath, swelling of ankles, cough or tiredness |

|A new cancer including cancer of bone marrow (leukemia) caused by chemotherapy |

|Swelling of the body including the brain which may cause dizziness, confusion |

|of the lungs |

|Damage to the pancreas causing abdominal pain |

|Damage or scarring of the lungs which may result in shortness of breath |

|Seizure |

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