Corresponding author: - University of Manchester



Outcomes Following Percutaneous Coronary Intervention (PCI) in Non-ST-segment Elevation Myocardial Infarction Patients with Coronary Artery Bypass GraftsAhmad Shoaib1 MD, Tim Kinnaird2 MD, Nick Curzen3 PhD, Evangelos Kontopantelis4 PhD, Peter Ludman5 MD, Mark de Belder6 MD, Muhammed Rashid1 MBBS, Chun Shing Kwok1 MBBS, James Nolan1 MD, Azfar Zaman7 MD, Mamas A Mamas1 DPhilOn behalf of the British Cardiovascular Intervention Society (BCIS) and the National Institute for Cardiovascular Outcomes Research (NICOR)1. Keele Cardiovascular Research Group,?Centre for Prognosis Research, Institute for Primary Care and Health Sciences, Keele University2. University Hospital of Wales, Cardiff, United Kingdom 3. University of Southampton, Southampton, United Kingdom 4. Institute for Primary Care Sciences, University of Manchester5. Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom 6. James Cook University Hospital, Middlesbrough, United KingdomNewcastle University, Newcastle Upon Tyne, United KingdomCorresponding author: Mamas A. MamasProfessor of CardiologyKeele Cardiovascular Research Group,?Centre for Prognosis Research, Institute for Primary Care and Health Sciences, Keele University, UKFax: +44 1782 734719, Phone: +44 1782 732958mamasmamas1@yahoo.co.ukSubject terms: Percutaneous coronary intervention, Vein GraftsAbstractBackground: There are limited data on outcomes of patients with previous CABG presenting with NSTEMI undergoing PCI. We compare clinical characteristics and outcomes in NSTEMI patients undergoing PCI with or without prior CABG surgery in a national cohort. Methods & Results: We identified 205,039 patients with NSTEMI who underwent PCI between 2007-2014 in the British Cardiovascular Intervention Society (BCIS) database. Clinical, demographical, procedural and outcome data were analysed by dividing into three groups; Group 1- PCI in native coronary arteries and no prior CABG (n= 186,670), Group 2- PCI in native arteries with prior CABG (n= 8,825), Group 3- PCI in Grafts (n= 9,544). Patients in Group 2 & 3 were older, had more comorbidities and higher mortality at 30 days (group 2 -2.6%, group 3 – 1.9%) and 1 year (group 2 – 8.29%, group 3 – 7.08%) as compared to Group 1 (1.7% & 4.87%). Following multivariable analysis, no significant difference in outcomes were observed in 30 days mortality (OR: group 2 = 0.87 (CI 0.69-1.80, P-0.20), group 3 = 0.91 (CI 0.71-1.17, P-0.46)), in-hospital MACE (OR: group 2 = 1.08 (CI 0.88-1.34, P- 0.45), group 3 0.97 (CI 0.77-1.23, P- 0.82)) and in-hospital stroke (OR: group 2 = 1.37 (CI 0.71-2.69, P - 0.35), group 3 = 1.13 (CI 0.55-2.34, P- 0.73))(group 1= reference).Conclusion: Patients with prior CABG presenting with NSTEMI and treated with PCI had more co-morbid illnesses but once these differences were adjusted for, prior CABG did not independently confer additional risk of mortality and MACE. Keywords: PCI, NSTEMI, Mortality, ComplicationsIntroductionIn the United States, more than 300,000 patients undergo Coronary Artery Bypass Grafts (CABG) surgery each year.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5FcHN0ZWluPC9BdXRob3I+PFllYXI+MjAxMTwvWWVhcj48

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ADDIN EN.CITE.DATA 1 Despite achieving complete revascularization with CABG, only 85% of internal mammary artery (IMA) and 60% of saphenous vein grafts (SVG) remained patent after 10 years.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Hb2xkbWFuPC9BdXRob3I+PFllYXI+MjAwNDwvWWVhcj48

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ADDIN EN.CITE.DATA 2 Occlusion of grafts may result in an acute coronary syndrome (ACS) and current European Society of Cardiology and North American guidelines recommend an invasive approach (Class 1-A) in the management of appropriately selected patients with a previous history of CABG.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IYW1tPC9BdXRob3I+PFllYXI+MjAxMTwvWWVhcj48UmVj

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ADDIN EN.CITE.DATA 5-8, although data are inconsistent ADDIN EN.CITE <EndNote><Cite><Author>Mathew</Author><Year>2002</Year><RecNum>331</RecNum><DisplayText><style face="superscript">9</style></DisplayText><record><rec-number>331</rec-number><foreign-keys><key app="EN" db-id="pe9ts0tvjferaqe5azfvf5s89t925pspr5dx" timestamp="0">331</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Mathew, V.</author><author>Gersh, B.</author><author>Barron, H.</author><author>Every, N.</author><author>Tiefenbrunn, A.</author><author>Frederick, P.</author><author>Malmgren, J.</author></authors></contributors><auth-address>Mayo Clinic, Rochester, Minn 55905, USA. mathew.verghese@mayo.edu</auth-address><titles><title>Inhospital outcome of acute myocardial infarction in patients with prior coronary artery bypass surgery</title><secondary-title>Am Heart J</secondary-title><alt-title>American heart journal</alt-title></titles><pages>463-9</pages><volume>144</volume><number>3</number><edition>2002/09/14</edition><keywords><keyword>Acute Disease</keyword><keyword>Aged</keyword><keyword>Bundle-Branch Block/*diagnosis</keyword><keyword>Comorbidity</keyword><keyword>Coronary Artery Bypass/*statistics &amp; numerical data</keyword><keyword>Electrocardiography/*statistics &amp; numerical data</keyword><keyword>Female</keyword><keyword>*Hospital Mortality</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Myocardial Infarction/*diagnosis/*mortality/surgery</keyword><keyword>Outcome Assessment (Health Care)</keyword><keyword>Registries</keyword><keyword>United States/epidemiology</keyword></keywords><dates><year>2002</year><pub-dates><date>Sep</date></pub-dates></dates><isbn>1097-6744 (Electronic)&#xD;0002-8703 (Linking)</isbn><accession-num>12228783</accession-num><work-type>Comparative Study</work-type><urls><related-urls><url>

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ADDIN EN.CITE.DATA 10 It is consistently reported in many clinical studies that patients with prior CABG are generally older, with worse demographic profiles and more complex and extensive coronary artery disease which may contribute to the higher mortality observed.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CcmlsYWtpczwvQXV0aG9yPjxZZWFyPjIwMTE8L1llYXI+

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ADDIN EN.CITE.DATA 10-12 Data that examines the outcomes of PCI separately in grafts and in native vessels in patients with prior CABG presenting with NSTEMI are limited. In an unselected cohort of 11,118 patients (including STEMI, NSTEMI, and stable angina patients) with prior CABG, PCI to grafts was associated with significantly higher mortality and MACE (MI, repeat revascularization) as compared to those who underwent PCI in native vessels at median 3 years follow up.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CcmlsYWtpczwvQXV0aG9yPjxZZWFyPjIwMTY8L1llYXI+

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ADDIN EN.CITE.DATA 13 By contrast, in another study of 47,557 patients with NSTEMI (8,790 had prior CABG), the adjusted risk of bleeding and in-hospital mortality did not differ significantly between the 2 groups (with and without prior CABG).PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LaW08L0F1dGhvcj48WWVhcj4yMDEwPC9ZZWFyPjxSZWNO

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ADDIN EN.CITE.DATA 14 However, no large contemporary study has compared outcomes after PCI in NSTEMI patients with and without previous CABG and in the latter, outcomes after PCI in native arteries against PCI to grafts. We therefore sought to describe the early (in-patient and 30 days) and late (1-year) outcomes of PCI in patients with and without a history of prior CABG presenting with NSTEMI in a large contemporary unselected national cohort from the database of the British Cardiovascular Intervention Society (BCIS). Outcomes were compared to the population with no history of prior CABG undergoing PCI for NSTEMI during the same study period. MethodsThis study was a retrospective analysis of prospectively recorded national data for all patients that underwent PCI for NSTEMI in England & Wales from January 2007 to December 2014 and the data that support the findings of this study are available from the corresponding author upon reasonable request. The British Cardiovascular Intervention Society (BCIS) collects data on all PCI procedures undertaken in the United Kingdom (UK) with data collection managed by the National Institute of Cardiovascular Outcomes Research (NICOR). Data input is mandatory, as part of the formal revalidation process, for all independent operators in the UK. The BCIS database consists of 113 clinical, procedural and outcome variables with approximately 80,000 new reports added each year.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Ld29rPC9BdXRob3I+PFllYXI+MjAxODwvWWVhcj48UmVj

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ADDIN EN.CITE.DATA 15-18 We used data from the Office of National Statistics (ONS) for mortality tracking in all patients of England & Wales by using their unique National Health Service number. We excluded patients from Scotland and Northern Ireland because of the absence of the ONS-linked mortality data. Institutional research and ethical board approval were not required for this study as all data were anonymized and routinely collected as part of the national audit, but the project was approved by a national Data and Monitoring Advisory Group on behalf of NICOR & BCIS. Data were collected on patients’ clinical characteristics, risk factors and comorbid conditions as well as aspects of interventional treatment and adjunctive drug therapy. We collected all-cause mortality during index admission and at 30 days and 1-year follow up. In addition, we assessed temporal changes in interventional practice for these patients from 2007-2014. We also analysed in-hospital major adverse cardiovascular events (MACE; defined as a composite of in-hospital mortality, in-hospital myocardial reinfarction, and target vessel revascularization), in-hospital major bleeding (described as arterial access site complication requiring surgery, gastrointestinal bleed, intracerebral bleed, retroperitoneal haematoma and blood or platelets transfusion), and in-hospital stroke which included ischaemic or haemorrhagic stroke or transient ischaemic attack (TIA). The study participants were divided into 3 groups: (Group 1) no prior CABG, (Group 2) previous CABG with PCI to native coronary arteries, and (Group 3) previous CABG with PCI to bypass grafts. Patients with missing data for mortality, sex, and age were excluded. We compared clinical characteristics across the three groups of interest and these comparisons were undertaken using Fisher’s exact tests for categorical and analysis of variance for continuous variables. We used multiple imputations with chained equations to impute data for all variables with missing information. We registered age, sex, group of participants, and study outcomes as complete variables in imputation models and these were used to produce 10 datasets on which we ran the analysis. Incomplete and imputed variables were smoking status, diabetes mellitus (DM), hypertension, hyperlipidaemia, previous MI, previous stroke, peripheral vascular disease, renal disease, family history of CAD, radial access site, glycoprotein IIb/IIIa inhibitors use, shock, circulatory support, number of stents, thrombus aspiration, mechanical ventilation and left ventricular systolic dysfunction. We applied multivariable logistic regression analysis to estimate the risk of adverse outcomes among groups. In multivariable analysis, we adjusted different covariates in the models included age, sex, smoking history, DM, hypertension, hypercholesterolemia, previous MI, peripheral vascular disease, renal insufficiency, family history of premature coronary disease, radial access site, glycoprotein IIb/IIIa inhibitor use, multivessel PCI, shock, circulatory support, number of stents, thrombus aspiration, mechanical ventilation, left ventricular systolic dysfunction, PCI to left main stem (LMS), PCI to left anterior descending artery (LAD) and use of distal protection devices. Almost 48% of data were missed in variable of Left Ventricular ejection fraction, 14% in family history of coronary artery disease, 10% in prior history of smoking and Myocardial infarction and less than 10% in all remaining variables (Table 1). Missing data can impair the ability to make correct inferences from observational studies. Complete case analysis is commonly applied but it reduces sample size and may lead to reduced statistical power. However, by using multiple imputation methods, sample size is preserved and they are generally regarded as preferred analysis technique. We used Multiple imputations with chained equations to impute missing data. It is already well reported in literature that Multiple imputation is the best technique among all missing-ness mechanisms and works well even very high level of data is missing. ADDIN EN.CITE <EndNote><Cite><Author>Kontopantelis</Author><Year>2017</Year><RecNum>789</RecNum><DisplayText><style face="superscript">19</style></DisplayText><record><rec-number>789</rec-number><foreign-keys><key app="EN" db-id="evxwdep2b92a5yedvt0ptsrr2swzw2drxpda" timestamp="1536929397">789</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Kontopantelis, Evangelos</author><author>Parisi, Rosa</author><author>Springate, David A.</author><author>Reeves, David</author></authors></contributors><titles><title>Longitudinal multiple imputation approaches for body mass index or other variables with very low individual-level variability: the mibmi command in Stata</title><secondary-title>BMC Research Notes</secondary-title></titles><periodical><full-title>BMC Research Notes</full-title></periodical><pages>41</pages><volume>10</volume><dates><year>2017</year><pub-dates><date>01/13&#xD;05/03/received&#xD;12/28/accepted</date></pub-dates></dates><pub-location>London</pub-location><publisher>BioMed Central</publisher><isbn>1756-0500</isbn><accession-num>PMC5234260</accession-num><urls><related-urls><url> For more clarity, we reported statistical models with complete case analysis as well as with multiple imputations. We also applied Multiple imputations with propensity score matching statistical techniques (miestimate: teffects psmatch) to estimate the average treatment effects for adjustment of baseline differences across the groups of patients. We applied two different multiple imputation logistic regressions models to calculate propensity score for each group member: (1) PCI to native coronary arteries without prior CABG (group 0) versus PCI to native arteries in patient with prior CABG (group 1); and PCI to native arteries without prior CABG (group 0) versus PCI to grafts (group 2). These scores were then applied to perform the matching, and simple logistic regression analysis was run (the sole predictor being group membership) to gain the average treatment effect. We also performed Kaplan-Meier survival analysis and Cox proportional hazards regression analysis for 30-days and 1-year mortality by patients group. Stata 13.1 statistical package was used for statistical analysis. ResultsStudy CohortOur study cohort comprised of 205,039 patients who had PCI during admission for NSTEMI in England and Wales from January 2007 to December 2014 and did not have missing data for mortality, follow up, gender and age. The process of patients’ inclusion and exclusion is presented in Figure 1. A total 186,670 (91%) patients had no history of prior CABG, whereas 18,369 (9%) had a history of previous CABG. In those patients with a history of prior CABG, 48% (n=8,825) underwent PCI to native coronary arteries, and 52% (n=9,544) had PCI to bypass grafts. The mean follow-up of these patients was 3.84 years (Standard deviation 2.3), and 94% were followed up for a minimum of 1 year (or until death, if occurring within this period). Clinical characteristics Significant differences in demographic, clinical and procedural characteristics of the 3 groups (Table 1) were observed. Specifically, patients with prior CABG were significantly older, less likely to be female, had a higher prevalence of DM, hypertension, hyperlipidaemia, PVD and previous MI or stroke (Table 1). Patients with prior CABG were also more likely to have moderate-severe left ventricle systolic dysfunction as compared to those without previous CABG. A steady increase in use of Drug eluting stents (DES) was observed among all three groups from 2007 – 2014 (Supplement figure 1). In 2007, 54%, 60% & 57% DES were used in Group 1, 2 & 3 which increased to 88%, 84% and 83% respectively in 2014. More patients in Group 3 (25%) received Glycoprotein IIb IIIa inhibitor as compare to others (Group 2: 16%, Group 1: 21%), which may indicate higher adverse clinical profile of this cohort, and the greater thrombotic environment encountered in SVGs. In group 2, a higher proportion of patients received LMS and multivessel PCI (group 2 = 26% & 19%, group 1 = 3 & 16 %, group 3 = 1.55% & 17%), presented with cardiogenic shock (group 2 = 1.5%, group 1= 1.2%, group 3 = 1%) and received circulatory support (group 2 = 2.7%, group 1 = 1.6%, group 3= 1.8%). In group 3, more patients were treated with thrombus aspiration (group 3 = 7.4%, group 1 = 4.6%, group 2 = 2.4%) and distal protection devices (group 3 = 18%, group 1= 0.4, group 2 = 1.3%). Overall, patients in group 2 & 3 had higher risk clinical and procedural profile as compared to those patients in group 1. Figure 2 demonstrates temporal patterns of interventional practice from 2007-14. Unadjusted outcomesThere were significant differences in unadjusted clinical outcomes (mortality and in-hospital MACE) among the three groups (Table 2). Unadjusted Kaplan-Meier survival estimates for all three groups at 30 days and one year are shown in figures 3-A and 3-B. Group 2 patients (Patients with previous CABG and PCI to native coronary arteries) had the highest mortality at 30 days (2.6%) and at 365 days (8.29%) as compared to those who had Group 3 (PCI to grafts) (1.9% & 7.08%) (P- 0.001 & 0.002) and Group 1 (PCI to native coronary arteries without prior CABG) (1.7% and 4.8%) (P-<0.0001) respectively (Table 2). In-hospital MACE rates showed similar patterns. Outcomes After Risk AdjustmentThe adjusted risk of mortality, MACE, major bleeding, and stroke outcomes are presented in Table 3. As big age difference was observed among three groups and we also undertook statistical analysis just controlling for age to compare the impact of the other risk factors (Supplement table 2). This analysis showed higher mortality during index admission (OR 1.28, CI 1.07-1.53, P=0.007), 30 days (OR 1.23, CI 1.07-1.42, P=0.003) in Group 2 and 1 year both in Group 2 (OR 1.41, CI 1.30-1.53, P=<0.0001) and Group 3 (OR 1.19, CI 1.10-1.30, P = <0.0001) as compare to Group 1. However, this difference in mortality lost its significance when we control other risk factors in statistical model (Table 3 & 4). In multivariate analysis, after adjustment of baseline dissimilarities, no significant differences were observed for in-patient mortality between Group 2 (for those who received PCI in native coronary arteries with prior CABG) (OR: 0.90, CI 0.73-1.11, P- 0.32) or Group 3 (PCI in Grafts) (OR: 0.90, CI 0.71-1.15, P-0.42) as compared to Group 1 (PCI in native vessels without previous CABG). Interestingly, PCI in Group 3 & 2 were associated with slightly better survival in Multivariable analysis on imputed data at 30 days as compare to Group 1. However, no significant difference in mortality was observed at follow up of one year for group 2 (OR: 0.92, CI 0.84-1.01, P – 0.09) and group 3 (OR: 0.99, CI 0.89-1.09, P-0.78) as compared to group 1 (Table 3). Likewise, for MACE during index admission, there were no significant differences in outcomes between group 2 versus group 1 (OR 1.08 (CI 0.88-1.34) and group 3 versus group 1 (OR 0.97 (CI 0.77-1.23) P= 0.82) after adjustment of baseline covariates. Similar findings were recorded for other in-hospital endpoints, with similar results observed irrespective of whether a complete case analysis was undertaken or multiple imputation for missing data was used. Analysis with Propensity Score-Matching Finally, we undertook a propensity score matching analysis. We did not observe any difference in outcomes among patients with or without prior CABG where PCI was performed in either the native coronary arteries or in the grafts (Table 4). Propensity score matching diagnostics success is presented in Supplement table 1, supplement Figures 2 A & B and it show that groups are balanced across all covariates after matching. DiscussionTo the best of our knowledge, this is the largest study to examine temporal trends, baseline clinical and procedural characteristics and outcomes in patients with a history of prior CABG presenting with NSTEMI and undergoing PCI. Our study demonstrates that patients with prior CABG are older with a greater comorbid burden and more complex procedural characteristics, but after adjustment of these differences, clinical outcomes were similar to patients undergoing PCI for NSTEMI without prior CABG.In our unadjusted analysis, patients with a history of CABG who underwent PCI to native coronary arteries (Group 2) had the highest in-patient, 30 days and 1-year mortality and in-patient MACE as compared to those patients who had PCI in grafts (Group 3), or in native arteries without the prior history of CABG (Group 1). We observe that patients with prior CABG are a higher-risk cohort, with a greater burden of comorbidities and adverse clinical profile, which might contribute to the unfavourable outcomes observed in unadjusted analyses. For example, patients with prior CABG were more likely to present with cardiogenic shock, undergo PCI to the left main stem (LMS), or multivessel PCI and were more often in receipt of circulatory support. After adjustment of such confounding factors, no statistically significant differences in clinical outcomes were observed in patients with or without previous CABG, regardless whether the PCI was performed in a native vessel or a graft, in the majority of the analyses although we did observe a reduced risk of 30-day mortality in some of the analyses that we undertook in the cohort of patients that had PCI in grafts (Group 3). Whilst this is statistically significant, whether this observation is clinically significant is unclear, and may relate to selection bias in that PCI is undertaken with a much higher threshold in patients with lesions in the SVG (undertaken in relatively “healthier” patients) compared to those with lesions in coronary native vessels.Indeed, previous studies have suggested that patients with prior CABG presenting with NSTEMI are less likely to receive early invasive treatment.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Lb2x0ZTwvQXV0aG9yPjxZZWFyPjIwMTY8L1llYXI+PFJl

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ADDIN EN.CITE.DATA 14 Similar findings were reported in the CRUSADE Quality Improvement Initiative, where high-risk patients were paradoxically less likely to receive invasive therapies despite having greater potential to get more benefit from a more aggressive approach.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CaGF0dDwvQXV0aG9yPjxZZWFyPjIwMDQ8L1llYXI+PFJl

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ADDIN EN.CITE.DATA 21 Such clinical practices might be driven by the paucity of data in NSTEMI patients with previous CABG undergoing PCI, or the perceived greater risk of adverse outcomes in such patients due to their higher risk clinical profile. Despite current guidelines recommending the use of distal protection devices (DPD) in PCI to Vein Grafts, we observed a relatively small proportion of patients (18%) receiving this adjunctive intervention. However, this finding is consistent with other observational studies. For instance, in US, use of DPD was limited to 21% of patients in National Cardiovascular Data registry. PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5NZWh0YTwvQXV0aG9yPjxZZWFyPjIwMDc8L1llYXI+PFJl

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ADDIN EN.CITE.DATA 23 There are several possible explanations for less use of these adjunctive devices in Vein Grafts PCI. For example, current devices are still bulky and add complexity to procedure. Secondly, they are not feasible for every case because of diverse anatomic profile and they are also not complication free. Furthermore, a recent meta-analysis of 52, 893 patients suggests no significant benefit in the routine use of DPD in contemporary real world practice (all-cause mortality (OR, 0.79; 95% CI 0.55-1.12; P=0.19), major adverse cardiovascular events (OR, 0.73; 95% CI 0.51-1.05; P=0.09), periprocedural MI (OR, 1.12; 95% CI, 0.65-1.90, P=0.69)). Most importantly, over time, relatively simpler techniques have been adopted to prevent distal embolization, including use of direct stenting and use of stents with nitinol mesh to reduce embolization and laser atherectomy.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Pa2FiZTwvQXV0aG9yPjxZZWFyPjIwMDg8L1llYXI+PFJl

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ADDIN EN.CITE.DATA 24-26 However these techniques have not been studied in well designed randomised controlled clinical trials. ADDIN EN.CITE <EndNote><Cite><Author>Waksman</Author><Year>2015</Year><RecNum>776</RecNum><DisplayText><style face="superscript">27</style></DisplayText><record><rec-number>776</rec-number><foreign-keys><key app="EN" db-id="evxwdep2b92a5yedvt0ptsrr2swzw2drxpda" timestamp="1532294495">776</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Waksman, R.</author><author>Koifman, E.</author></authors></contributors><auth-address>From the Section of Interventional Cardiology, MedStar Washington Hospital Center, Washington, DC. ron.waksman@.&#xD;From the Section of Interventional Cardiology, MedStar Washington Hospital Center, Washington, DC.</auth-address><titles><title>Embolic protection device for saphenous vein graft intervention: too early to take off the seat belt</title><secondary-title>Circ Cardiovasc Interv</secondary-title><alt-title>Circulation. Cardiovascular interventions</alt-title></titles><periodical><full-title>Circ Cardiovasc Interv</full-title><abbr-1>Circulation. Cardiovascular interventions</abbr-1></periodical><alt-periodical><full-title>Circ Cardiovasc Interv</full-title><abbr-1>Circulation. Cardiovascular interventions</abbr-1></alt-periodical><pages>e002371</pages><volume>8</volume><number>3</number><edition>2015/02/26</edition><keywords><keyword>*Embolic Protection Devices</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Saphenous Vein/*surgery</keyword><keyword>Vascular Grafting/*methods</keyword><keyword>Editorials</keyword><keyword>percutaneous coronary intervention</keyword></keywords><dates><year>2015</year><pub-dates><date>Mar</date></pub-dates></dates><isbn>1941-7640</isbn><accession-num>25714392</accession-num><urls></urls><electronic-resource-num>10.1161/circinterventions.115.002371</electronic-resource-num><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>27 Nevertheless, more compelling data is needed which can evaluate the performance of DPD and other modern Interventional techniques in randomised clinical trials to prevent distal embolization in Vein Grafts PCI. Studies describing outcomes in patients presenting with NSTEMI and a prior history of CABG have reported variable findings, although such prior studies have not focussed specifically according to whether the PCI was undertaken in a native vessel or graft vessel in this cohort of patients with prior CABG. In a study of 47,557 patients presenting with NSTEMI, in which 8,790 patients had prior CABG, the adjusted risk of bleeding and in-hospital mortality did not differ significantly between the prior CABG and no CABG group, although this study included patients managed both medically and invasively with PCI PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LaW08L0F1dGhvcj48WWVhcj4yMDEwPC9ZZWFyPjxSZWNO

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ADDIN EN.CITE.DATA 28 Data derived from the National Cardiovascular Data Registry of 11,118 patients with prior CABG showed that the majority of PCI procedures in this cohort of patients were performed in native coronary arteries (73%) and rest in bypass grafts. In the Multivariable analysis, significantly higher mortality (HR 1.3, CI 1.18-1.42), MI (HR 1.61, CI 1.43-1.82) and repeat revascularization (HR 1.60, CI 1.5-1.7) were observed in patients who received PCI in grafts at a median follow up of 3.1 years. However, this study didn’t report outcomes specifically for NSTEMI.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CcmlsYWtpczwvQXV0aG9yPjxZZWFyPjIwMTE8L1llYXI+

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ADDIN EN.CITE.DATA 11 Strengths & LimitationsThis study has several strengths. The BCIS dataset comprises of almost complete record of all PCI procedures undertaken in the UK which represent unselected real-world experience, containing high-risk patients with multiple comorbidities often not included in clinical trials, and represents the largest analysis of PCI for NSTEMI patients with prior CABG to be published. PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5JcWJhbDwvQXV0aG9yPjxZZWFyPjIwMTY8L1llYXI+PFJl

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ADDIN EN.CITE.DATA 29 To the best of our knowledge, no national cohort study has examined clinical outcomes in NSTEMI patients with the previous history of CABG who undergo PCI to grafts or native arteries and compared with those who did not have CABG. Our large sample size gives us sufficient statistical power to capture differences in clinical outcomes between the patient grouped studied. Furthermore, given patients with prior CABG are often excluded or under-represented in landmark PCI trials, and so our data represents best available current evidence in this cohort.A major inherent limitation of our study was that it was based on retrospective analysis of national registry data and hence was subject to all the limitations of observational studies. Secondly, whilst mortality tracking within England & Wales is well structured, all other clinical outcomes and post procedural complication are self-reported without official adjudication. Therefore, such outcomes are vulnerable to reporting biases, and complications may be under-reported, although it is unlikely that there will be differences in such reporting biases in the three groups studied. Thirdly, this data set does not contain information about patients who were admitted with NSTEMI but who were managed medically or underwent cardiac catheterisation and no PCI was performed. Therefore, our findings are only applicable to patients who undergo PCI and cannot be used to inform around outcomes in the wider cohort of NSTEMI patients. Finally, BCIS dataset does not record information about the nature of Grafts (Arterial or Venous), although it is likely that the majority of PCI were performed in saphenous vein grafts, as previous data derived from the National Cardiovascular Data Registry (NCDR) reported that arterial grafts represented only 2.5% of all PCI procedures undertaken in bypass grafts in the US.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CcmlsYWtpczwvQXV0aG9yPjxZZWFyPjIwMTE8L1llYXI+

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ADDIN EN.CITE.DATA 11 Conclusion Our study demonstrates that close to one in eleven patients who present with NSTEMI and undergo PCI are patients with prior CABG. These patients are a higher risk group that are older, have more comorbid conditions and present with more haemodynamic compromise. However, after adjustment of differences in baseline clinical and procedural characteristics, we report that clinical outcomes are not significantly different in patients who undergo PCI to the grafts or native vessels, when compared with those patients that have not had prior CABG. Whilst PCI to bypass grafts is technically more demanding and complex, our study demonstrates reassuring data for short and medium term clinical outcomes- the presence of prior CABG should not be a factor in deciding on invasive management after presentation with NSTEMI. Our study suggests that the excess of cardiac events and death seen in patients with prior CABG relates more to the comorbid burden of the patients than to the fact that coronary intervention itself increases risk of these events.External funding: NoneConflict of interest: NoneFigures & Tables Figure 1: Flow chart of participant inclusion. PCI indicates percutaneous coronary intervention251460054102000800100883920Patients with missing data for age n = 151, sex n = 391, Mortality follow up n = 12,745 and for PCI records n = 2,26600Patients with missing data for age n = 151, sex n = 391, Mortality follow up n = 12,745 and for PCI records n = 2,2668001001798320Total cohort: 205,039Group 1: PCI to Native coronary arteries: 186,670 (91.04 %)Group 2: PCI to Native coronary arteries in previous CABG patients: 8,825 (4.30%)Group 3: PCI to Grafts: 9,544 (4.65%)00Total cohort: 205,039Group 1: PCI to Native coronary arteries: 186,670 (91.04 %)Group 2: PCI to Native coronary arteries in previous CABG patients: 8,825 (4.30%)Group 3: PCI to Grafts: 9,544 (4.65%)2514600145542000114300083820Total NSTEMI patients received PCI in England and Wales from 2007-2014 = 220,59200Total NSTEMI patients received PCI in England and Wales from 2007-2014 = 220,592 Figure 2 A & B: Temporal Pattern of PCI practice from 2007-2014PCI: Percutaneous Coronary InterventionFigure 3-A & B: Kaplan-Meier Survival estimates at 30 and 365 days13970001000760Log rank P <0.00100Log rank P <0.00110287001181100Log rank P <0.00100Log rank P <0.001PCI: Percutaneous Coronary InterventionGroup 1: PCI to Native ArteriesGroup 2: PCI to Native Arteries in Prior Coronary Artery Bypass Grafts Group 3: PCI to GRAFTSTable SEQ Table \* ARABIC 1: Baseline Clinical CharacteristicsVariable Missing dataGroup 1 (n=186,670) PCI to Native arteriesGroup 2 (n=8,825) PCI to Natives with prior CASBGGroup 3 (n=9,544) PCI to GraftsP- ValueAge (IQR)065 (55-74)70 (63-77)71 (63-77)<0.0001Female sex 052,758/186,670(28%)1,932/8,825 (22%)1,755/9,544 (18%)<0.0001Smoking 20,828 (10%)112,222/167,988 (67%)5,108/7,846 (65%)5,470/8,377 (65%)<0.0001Diabetes mellitus 7,110 (3%)34,794/180,252 (19%)2,939/8,489 (35%)2,967/9,188 (32%)<0.0001Hypertension 7,320 (4%)98,239/179,992 (55%)6,005/8,556 (70%)5,989/9,171 (65%)<0.0001Hyperlipidaemia 7,320 (4%)102,611/179,992 (57%)5,851/8,556 (68%)5,998/9,171 (65%)<0.0001Previous MI19,876 (10%)43,596/168,578 (26%)5,003/7,968 (63%)5,425/8,617 (63%)<0.0001Previous CVA 7,320 (4%)7,873/179,992 (4%)657/8,556 (8%)665/9,171 (7%)<0.0001Peripheral vascular disease 7,320 (4%)9,263/179,992 (5%)941/8,556 (11%)1,004/9,171 (11%)<0.0001Previous renal disease 11,448 (6%)2,613/176,673 (1.48%)248/8,071 (3.07%)199/8,847 (2.25%)<0.0001Family history of heart disease27,931(14%)72,721/161,514 (45%)3,582/7,485 (48%)3,693/8,109 (46%)<0.0001Glycoprotein IIb/IIIa inhibitor 13,574 (7%)37,338/174,244 (21%)1,294/8,310 (16%)2,213/8,911 (25%)<0.0001LVEF98,598 (48%) Good (EF >50%) 66,422/97,022 (69%)2,442/4,855 (50%)2,274/4,564 (50%)<0.0001 Moderate (EF 30-50%) 24,392/97,022 (25%)1,819/4,855 (38%)1,741/4,564 (38%)<0.0001 Poor (EF <30%)6,208/97,022 (6%)594/4,855 (12%)549/4,564 (12%)<0.0001Access site4,583 (2%) Femoral 77,540/182,551 (43%)6,032/8,684 (70%)6,304/9,221 (68%)<0.0001 Radial 100,938/182,551 (55%)2,452/8,684 (28%)2,707/9,221 (29%)<0.0001 Multiple3,675/182,551 (2%)164/8,684 (2%)183/9,221 (2%)<0.0001Target vessel0LAD 093,949/186,670 (50%)2,539/8,825 (29%)593/9,544 (6%)<0.0001Left main stem05,938/186,670 (3%)2,301/8,825 (26%)148/9,544 (1.55%)<0.0001Left Circumflex 053,250/186,670 (29%)3,412/8,825 (39%)609/9,544 (6%)<0.0001Right coronary artery 067,037/186,670 (36%)2,542/8,825 (29%)551/9,544 (6%)<0.0001Graft 0009,544 (100%)<0.0001Multivessel PCI 029,871/186,670 (16%)1,693/8,825 (19%)1,646/9,544 (17%)<0.0001Cardiogenic shock 4,004 (2%)2,247/182,969 (1.2%)134/8,721 (1.5%)93/9,345 (1%)0.004Circulatory support 11,723 (6%)2,716/175,671 (1.6%)226/8,516 (2.7%)164/9,129 (1.8%)<0.0001DES use 8,742 (4%)129,878/178,601 (73%)6,269/8,574 (73%)6,195/9,122 (68%)<0.0001Number of stents2,680 (1%)0 11,218/184,156 (6%)914/8,774 (10.4%)758/9,429 (8%)<0.00011 101,047/184,156 (55%)4,313/8,774 (49%)5,096/9,429 (54%)<0.00012 46,415/184,156 (25%)2,165/8,774 (25%)2,230/9,429 (24%)<0.0001≥3 25,476/184,156 (14%)1,382/8,774 (16%)1,345/9,429 (14%)<0.0001Thrombus aspiration 11,303 (6%)8,134/176,172 (4.6%)203/8,449 (2.4%)678/9,115 (7.4%)<0.0001Mechanical ventilator support 24,013 (12%)1,741/164,823 (1.1%)119/7,991 (1.5%)128/8,212 (1.6%)<0.0001Use of distal protection device 11,464 (6%)660/175,980 (0.4%)113/8,448 (1.3%)1,676/9,147 (18%)<0.0001Median follow up time (IQR)01,333 (665-2,104)1,141 (551-1,929)1,332 (667-2,191)0.0001Mean follow up time (SD)01,406 (850)1,275 (845)1,422 (876)0.0001PCI: Percutaneous Coronary InterventionGroup 1: PCI in native coronary arteries; Group 2: PCI in native coronary arteries in patient with CABG; Group 3: PCI in bypass grafts. CVA indicates cerebrovascular accident; DES, drug-eluting stent; LAD, left anterior descending; LVEF, left ventricular ejection fraction;, EF; Ejection Fraction, MI, myocardial infarction; and PCI, percutaneous coronary intervention, IQR; Interquartile range, SD: Standard deviation, CABG; Coronary Artery Bypass Grafts Table 2: Unadjusted Clinical OutcomesOutcome Group 1 (n=186,670) PCI to NativeGroup 2 (n=8,825) PCI to Native in CABGGroup 3 (n=9,544)PCI to GRAFTS P-value comparing in all groupsIn-hospital mortality 1,812/186,670 (0.97%)136/8,825 (1.54%)105/9,544 (1.1%)<0.000130-day mortality 3,182/186,670 (1.7%)230/8,825 (2.6%)181/9,544 (1.9%)<0.00011-year mortality 9,090/186,670 (4.87%)732/8,825 (8.29%)676/9,544 (7.08%)<0.0001In-hospital MACE 2,542/183,311 (1.39%)184/8,645 (2.13%)143/9,386 (1.52%)<0.0001In-hospital reinfarction 664/183,311 (0.36%)47/8,645 (0.54%)39/9,386 (0.42%)0.02In-hospital reintervention 644/183,311 (0.35%)49/8,645 (0.57%)30/9,386 (0.32%)<0.0001In-hospital emergency cardiac surgery 447/183,311 (0.24%)12/8,645 (0.14%)4/9,386 (0.04%)<0.0001In-hospital Stroke 205/183,311 (0.11%)12/8,645 (0.14%)16/9,386 (0.17%)0.22In-hospital bleeding 1,575/183,323 (0.86%)83/8,646 (0.96)85/9,388 (0.91%)0.56Group 1: Primary PCI in native coronary arteries; Group 2: Primary PCI in native coronary arteries in patient with CABG; Group 3: Primary PCI in bypass grafts. CABG indicates coronary artery bypass graft; MACE, major adverse cardiovascular events; PCI, percutaneous coronary intervention; and TIA, transient ischemic attack. *P value determined by Chi Square test with two degree of freedom Table SEQ Table \* ARABIC 3: Risk of Adverse Outcomes following multivariate adjustmentVariable Group 1: PCI in Native Coronary Arteries Group 2: PCI in Native Coronary Arteries in Patient with prior CABG Group 3: PCI in Bypass Grafts In-hospital mortality Adjusted OR(N for analysis= 129,103)ReferenceOR 0.94 (CI 0.70-1.26) P = 0.670.88 (CI 0.62- 1.23) P = 0.49Adjusted OR?(N for analysis= 201,329)Reference OR 0.90 (CI 0.73-1.11) P = 0.32OR 0.90 (CI 0.71-1.15) P = 0.4230-day mortality Adjusted OR(N for analysis= 129,103) ReferenceOR 0.87 (CI 0.69-1.80) P = 0.20OR 0.91 (CI 0.71-1.17) P = 0.46Adjusted HR(N for analysis= 128,855)ReferenceHR 0.96 (CI 0.74-1.25), P = 0.77HR 0.73 (CI 0.51-1.06) P = 0.09Adjusted OR?(N for analysis= 201,329) Reference OR 0.85 (CI 0.72-0.99) P = 0.04OR 0.84 (CI 0.70-1.007) P = 0.06Adjusted HR?(N for analysis= 201,329)ReferenceHR 0.94 (CI 0.88-0.99) P = 0.04HR 0.78 (CI 0.72-0.84) P = <0.00011-y mortality Adjusted OR (N for analysis= 129,103)ReferenceOR 0.95 (CI 0.84-1.07) P = 0.37OR 1.02 (CI 0.90 – 1.17) P = 0.72Adjusted HR(N for analysis= 128,855)ReferenceHR 0.98 (CI 0.85-1.13) P = 0.80HR 0.90 (CI 0.76-1.06) P = 0.21Adjusted OR?(N for analysis= 201,329)Reference OR 0.92 (CI 0.84-1.01) P = 0.09OR 0.99 (CI 0.89-1.09) P = 0.78Adjusted HR?(N for analysis= 201,329)ReferenceHR 0.96 (CI 0.92-0.99) P = 0.02HR 0.96 (CI 0.92-0.99) P = 0.03In-hospital MACE Adjusted OR(N for analysis= 125,889)ReferenceOR 1.08 (CI 0.88-1.34) P = 0.45OR 0.97 (CI 0.77-1.23) P = 0.82Adjusted OR?(N for analysis= 201,329)Reference OR 1.01 (CI 0.84-1.19) P = 0.99OR 0.86 (CI 0.71-1.05) P = 0.13In-hospital stroke Adjusted OR(N for analysis= 125,889)ReferenceOR 1.37 (CI 0.71-2.69) P = 0.35OR 1.13 (CI 0.55-2.34) P = 0.73Adjusted OR?(N for analysis= 201,329)Reference OR 1.01 (CI 0.54-1.84) P = 0.99OR 1.21 (0.68 – 2.13) P = 0.52In-hospital bleeding Adjusted OR(N for analysis= 127,690)ReferenceOR 0.68 (CI 0.51-0.92) P = 0.01OR 0.99 (CI 0.75-1.33) P = 0.98Adjusted OR?(N for analysis= 201,329)Reference OR 0.78 (CI 0.62-0.98) P = 0.04OR 0.91 (CI 0.71-1.16) P = 0.46OR; Odds Ratio, HR; Hazard Ratio, CABG indicates coronary artery bypass graft; MACE, major adverse cardiovascular events; and PCI, percutaneous coronary intervention, N; Number Adjusted on Non-Imputed data (Complete case analysis)? Adjusted on Imputed dataVariables for Statistical models: age, sex, smoking status, diabetes mellitus, hypertension, hyperlipidemia, previous myocardial infarction, previous stroke, peripheral vascular disease, renal disease, family history, radial access site, glycoprotein IIb/IIIa inhibitor, multivessel, PCI to left anterior descending artery, PCI to left main artery, shock, circulatory support, number of stents, thrombus aspiration, ventilation and distal protection device Table 4: Propensity Score-Matched Analysis with Average Treatment Effects & Odds Ratio on imputed dataAnalysis Group Coefficient (95% CI) OR (95% CI)P Value In-hospital mortality Group 1: PCI in native coronary arteries Reference Group 2: PCI in native coronary arteries in patient with CABG (N=122,265)0.0048 (-0.002 to0.012)1.50(0.79-2.26)0.17Group 3: PCI in bypass grafts (N= 122,434)-0.0032 (-0.0068 to 0.0003)0.67(0.30-1.03)0.0830-day mortality Group 1: PCI in native coronary arteriesReference Group 2: PCI in native coronary arteries in patient with CABG (N=122,265)0.0041(-0.0044 to 0.0125)1.25(0.74-1.76)0.34Group 3: PCI in bypass grafts (N=122,434)- 0.0064 (-0.0106 to -0.0021)0.62(0.37-0.88)0.0031-y mortality Group 1: PCI in native coronary arteries Reference Group 2: PCI in native coronary arteries in patient with CABG (N=122,265)0.0109 (-0.0016 to 0.0234)1.24(0.97-1.52)0.09Group 3: PCI in bypass grafts (N=122,434)-0.0032(-0.0315 to 0.025)0.93(0.34-1.55)0.81In-hospital MACE Group 1: PCI in native coronary arteries Reference Group 2: PCI in native coronary arteries in patient with CABG (N=122,265) 0.0091(-0.0002 to 0.0185)1.67(0.98-2.38)0.055Group 3: PCI in bypass grafts (N=122,434) -0.0038(-0.0094 to 0.0017)0.72(0.32-1.12)0.18PCI; percutaneous coronary intervention, CABG; indicates coronary artery bypass graft, MACE; major adverse cardiovascular events, CI; confidence interval, OR: Odds ratioN: Number of observationsSupplement Patients selectionTotal Number of Records: 669,279Data available from England & Wales: 593,058NSTEMI: 220,592Age DataMissing: 151 (Dropped)available data after excluding missing data: 220,441 Gender dataNot specified: 29 (Dropped)Missing data: 362 (Dropped)Available data after excluding missing data: 220,050In Patient Mortality Follow upMissing data for inpatient Mortality: 4,049Remaining data after excluding missing data for in-patient Mortality: 216,00130 Days Mortality DataMissing data for 30 days Mortality: 8,622Remaining data after excluding missing data for 30 days Mortality: 207,37990 Days Mortality DataMissing data for 90 days Mortality: 0Remaining data after excluding missing data for 90 days Mortality: 207,379365 Days Mortality DataMissing data for 365 days Mortality: 27Remaining data after excluding missing data for 365 days Mortality: 207,352Final Censorship Days Mortality DataMissing data for Mortality at final censorship date: 47Remaining data after excluding missing data for final censorship Mortality: 207,305PCI DataMissing data for PCI Records: 2,266Remaining data after excluding missing data for PCI records: 205,039Total cohort available for final analysis: 205,039PCI to Native coronary arteries: 186,670 (91.04 %)PCI to Native coronary arteries in previous CABG patients: 8,825 (4.30%)PCI to Grafts: 9,544 (4.65%)lefttopSupplement Figure 1: Temporal Pattern of use of Drug eluting stent from 2007-2014Supplement Figure 2-A: Propensity score before and after Matching in Group 1 vs Group 2Supplement Figure 2-B: Propensity score before and after Matching in Group 1 versus Group 3Group 1; PCI to Native coronary arteriesGroup 2: PCI to Native coronary arteries in previous Coronary Artery Bypass Grafts (CABG) patientsGroup 3: PCI to Grafts Supplement table 1: Matching success diagnostics for propensity modelAnalysis Group GroupMean (SD)Median (IQR)In Patient MortalityPCI in native coronary arteries in patients with CABG versus PCI in nativeCase 1(PCI in native with CABG)0.9549 (0.0769)0.9797 (0.9538-0.9898)Control (PCI in Native)0.9549 (0.0768)0.9797 (0.9538-0.9898)Abs (Case-Control)0.0000208(0.000597)0.0000066 (0.0000019-0.0000151)PCI in GRAFTS versus PCI in nativeCase 1(PCI in GRAFTS)0.9512 (0.1049)0.9856 (0.9527-0.9971)Control (PCI in Native)0.9512 (0.1048)0.9856 (0.9526-0.9971)Abs (Case-Control)0.0000423 (0.00019)0.0000114 (0.0000029-0.000029830-day mortality PCI in native coronary arteries in patients with CABG versus PCI in nativeCase 1(PCI in native with CABG)0.9549 (0.7696)0.9797 (0.9538-0.9898)Control (PCI in Native)0.9549 (0.7689)0.9797 (0.9538-0.9898)Abs (Case-Control)0.0000208 (0.000597)0.00000668 (0.00000191-0.0000151)PCI in GRAFTS versus PCI in nativeCase 1(PCI in GRAFTS)0.9512 (0.1049)0.9856 (0.9527-0.9971)Control (PCI in Native)0.9512 (0.1048)0.9856 (0.9526-0.9971)Abs (Case-Control)0.0000423(0.0001904)0.0000114 (0.00000298-0.0000298)1-y mortality PCI in native coronary arteries in patients with CABG versus PCI in nativeCase 1(PCI in native with CABG)0.9549 (0.7696)0.9797 (0.9538-0.9898)Control (PCI in Native)0.9549 (0.7689)0.9797 (0.9538-0.9898)Abs (Case-Control)0.0000208 (0.000597)0.00000668 (0.00000191-0.0000151)PCI in GRAFTS versus PCI in nativeCase 1(PCI in GRAFTS)0.9512 (0.1049)0.9856 (0.9527-0.9971)Control (PCI in Native)0.9512 (0.1048)0.9856 (0.9526-0.9971)Abs (Case-Control)0.0000423 (0.0001904)0.0000114 (0.00000298-0.0000298) MACEPCI in native coronary arteries in patients with CABG versus PCI in nativeCase 1(PCI in native with CABG)0.9549 (0.7696)0.9797 (0.9538-0.9898)Control (PCI in Native)0.9549 (0.7689)0.9797 (0.9538-0.9898)Abs (Case-Control)0.0000208 (0.000597)0.00000668 (0.00000191-0.0000151)PCI in GRAFTS versus PCI in nativeCase 1(PCI in native with CABG)0.9512 (0.1049)0.9856 (0.9527-0.9971)Control (PCI in Native)0.9512 (0.1048)0.9856 (0.9526-0.9971)Abs (Case-Control)0.0000423 (0.0001904)0.0000114 (0.00000298-0.0000298)PCI; percutaneous coronary intervention, CABG; indicates coronary artery bypass graft, MACE; major adverse cardiovascular eventsSupplement Table 2: Analysis controlling for age onlyAnalysis Group OR95% Confidence IntervalP Value In-hospital mortality Group 1: PCI in native coronary arteries Reference Group 2: PCI in native coronary arteries in patient with CABG1.281.07-1.530.007Group 3: PCI in bypass grafts(0.920.75-1.120.3930-day mortality Group 1: PCI in native coronary arteriesReference Group 2: PCI in native coronary arteries in patient with CABG (n=191,943)1.231.07-1.420.003Group 3: PCI in bypass grafts(n=192,689)0.920.79-1.070.291-y mortality Group 1: PCI in native coronary arteries Reference Group 2: PCI in native coronary arteries in patient with CABG (n=191,943)1.411.30-1.53<0.0001Group 3: PCI in bypass grafts (192,689)1.191.10-1.30<0.0001In-hospital MACE Group 1: PCI in native coronary arteries Reference Group 2: PCI in native coronary arteries in patient with CABG (n=191,943) 1.321.14-1.54<0.0001Group 3: PCI in bypass grafts (n= 192,689) 0.950.80-1.130.56PCI; 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