Cambridge University Press



Supplementary Table 1: Study characteristics for 179 studies eligible for inclusion in a systematic review evaluating the efficacy of bacterial vaccines to prevent respiratory disease in swine. StudyCountrySettingYear conducted# farmsReason for vaccinatingOutcomesAbs El-Osta and Youil, 2014AustraliaCommercialNR1Endemic diseaseLung lesions ****Arsenakis et al., 2017BelgiumCommercial2013-20142Endemic diseaseCough index, lung lesions §, mortalityBaccaro et al., 2002BrazilCommercial19991Endemic diseaseLung lesions §, mortalityBaccaro et al., 2006BrazilCommercial2001-20021Endemic diseaseLung lesions §, mortalityBak and Norregaard, 2011SwedenCommercialNR2Prevention of clinical diseaseLung lesions ??, mortalityBeffort et al., 2017 GermanyCommercialNR1Endemic diseaseLung lesions §§, mortalityBerrocal et al., 2000SpainCommercial1999-20004Prevention of clinical diseaseLung lesions §Beskow et al., 1989**SwedenCommercialNR1Prevention of clinical diseaseLung lesions §Beskow et al., 1989**SwedenCommercialNR1Prevention of clinical diseaseLung lesions §Beskow et al., 1989**SwedenCommercialNR1Prevention of clinical diseaseLung lesions §Beskow et al., 1989**SwedenCommercialNR1Prevention of clinical diseaseLung lesions §Beskow et al., 1989**SwedenCommercialNR1Prevention of clinical diseaseLung lesions §Beskow et al., 1989**SwedenCommercialNR1Prevention of clinical diseaseLung lesions §Beskow et al., 1989**SwedenCommercialNR1Prevention of clinical diseaseLung lesions §Beskow et al., 1993NRCommercialNR5Endemic diseaseLung lesions §Bilic et al., 1996CroatiaCommercial1993-19941Endemic diseaseClinical illness, lung lesions §Bloxham, 1987**NRCommercialNA1Endemic diseaseMortality ***Bloxham, 1987**NRCommercialNA1Endemic diseaseMortality ***Bordin et al., 2010BrazilCommercialNR1NRLung lesions, mortalityBouwkamp et al., 2000NetherlandsCommercialNR1Endemic diseaseMortalityCastaing et al., 2002FranceUniversity/ResearchNR1Prevention of clinical diseaseLung lesions §§Charlier et al., 1994**FranceCommercialNR1Endemic diseaseLung lesionsCharlier et al., 1994**FranceCommercialNR1Endemic diseaseLung lesionsCharlier et al., 1994**FranceCommercialNR1Endemic diseaseLung lesionsCharlier et al., 1994**FranceCommercialNR1Endemic diseaseLung lesionsChouet et al., 2014FranceCommercialNR4Endemic diseaseLung lesionsClark et al., 1994USACommercialNR1Prevention of clinical diseaseLung lesions*Costa et al., 2015BrazilCommercial20133Endemic diseaseLung lesions §Cvjetkovic et al., 2018AustriaCommercial2016-20171Endemic diseaseClinical illness, cough index, lung lesions, mortalityDawson et al., 2002**Germany, EnglandCommercial1999-200012Endemic diseaseMortalityDawson et al., 2002**EnglandCommercial1999-20001Endemic diseaseLung lesions §§Dawson et al., 2002** EnglandCommercial1999-20001Endemic diseaseLung lesions§§Dawson et al., 2002** EnglandCommercial1999-20001Endemic diseaseLung lesions§§Dawson et al., 2002** EnglandCommercial1999-20001Endemic diseaseLung lesions§§Dawson et al., 2002** EnglandCommercial1999-20001Endemic diseaseLung lesions§§Dawson et al., 2002** EnglandCommercial1999-20001Endemic diseaseLung lesions§§Dawson et al., 2002**Germany Commercial1999-20001Endemic diseaseLung lesions§§Dawson et al., 2002**Germany Commercial1999-20001Endemic diseaseLung lesions§§Dawson et al., 2002**Germany Commercial1999-20001Endemic diseaseLung lesions§§Del Pozo Sacristan et al., 2014aBelgiumCommercial20111Endemic diseaseClinical illness, lung lesions §, §§, mortality, total antibiotic useDel Pozo Sacristan et al., 2014b**BelgiumCommercial20121Endemic diseaseMortality, total antibiotic useDel Pozo Sacristan et al., 2014b**BelgiumCommercial20121Endemic diseaseMortality, total antibiotic useDel Pozo Sacristan et al., 2014b**BelgiumCommercial20122Endemic diseaseLung lesionsDíaz et al., 2004aMexicoCommercial2002-20032NRLung lesions*Díaz et al., 2004bMexicoCommercialNRMultiple sitesNRLung lesionsDíaz et al., 2004cMexicoCommercialNR2NRLung lesions*Dirven et al., 2006NetherlandsCommercialNR2Endemic diseaseMortalityDocic and Bilkei, 2001NRCommercialNR1Endemic diseaseLung lesions§§Dohoo and Montgomery, 1996CanadaCommercialNR1 (sow herd and grower pig barns on different farms) Prevention of clinical diseaseLung lesionsDouglas and Ripley, 1984NRCommercial1982-19831Prevention of clinical diseaseClinical illness****Duff et al., 2011USACommercialNR1Endemic diseaseMortalityDuivon et al., 2018FranceCommercialNR1Endemic diseaseLung lesions****Etoré et al., 2005FranceCommercial20032NRLung lesions*Fenwick et al., 1986NRCommercialNR3Endemic diseaseClinical illness, mortalityF?ldi et al., 2014HungaryCommercialNR1Endemic diseaseClinical illness, lung lesions §§, mortalityGarlaite et al., 2004LithuaniaCommercialNR3Endemic diseaseLung lesions*Genzow et al., 2006AustriaCommercialNR1Endemic diseaseLung lesions*Goman et al., 2014NRCommercial NR1Endemic diseaseLung lesions §, mortality ??Goodnow et al., 1979USACommercialNR2Endemic diseaseClinical illness ****Gunther et al., 2000FranceCommercial NR3Endemic diseaseLung lesions §, mortalityHabrun et al., 2002CroatiaCommercial19991Endemic diseaseLung lesions §, mortalityHaruna et al., 2006CanadaCommercial20021Endemic diseaseMortalityHenninger and Morel-Saives, 2013**FranceCommercial20113NRLung lesions ****Henninger and Morel-Saives, 2013**FranceCommercial20116NRLung lesions ****Henninger and Morel-Saives, 2013**FranceCommercial20111NRLung lesions ****Herczeg et al., 2012aSouth AfricaCommercial20121Prevention of clinical diseaseClinical illness ?, mortality ?Herczeg et al., 2012bMexicoNRNR1Endemic diseaseMortalityHolyoake and Callinan, 2006AustraliaCommercial20021Endemic diseaseMortalityJin et al., 2013KoreaCommericalNR1Endemic diseaseMortality ****Jirawattanapong et al., 2008NetherlandsUniversity/ResearchNR1Endemic diseaseClinical illness, lung lesionsJoisel and Rice, 2000NRCommercialNR1NRLung lesions*Kaalberg et al., 2017NetherlandsCommercial2014-20151Endemic diseaseLung lesions, mortalityKaeoket et al., 2006ThailandCommercialNR1Endemic diseaseCough indexKessler and Lahrmann, 2004NRCommercialNR1Endemic diseaseLung lesions*Kongtes et al., 2013ThailandCommercialNR1Prevention of clinical diseaseMortalityKrejci et al., 2011aBelarusCommercialNR1Endemic diseaseMortality ****Krejci et al., 2011bBelarusCommercialNR1Endemic diseaseMortalityKrejci et al., 2013NRNRNR1Endemic diseaseLung lesions §, mortality ****Krejci and Revesz, 2013NRCommercialNR1Endemic diseaseLung lesions §, mortality ??Kristensen et al., 2014**DenmarkCommercialNR1Endemic diseaseClinical illness, lung lesions §, mortalityKristensen et al., 2014**DenmarkCommercialNR1Endemic diseaseClinical illness, lung lesions §, mortalityKyriakis et al., 2001GreeceCommercialNR1Endemic diseaseLung lesions §§Lara et al., 2014NRCommercialNR1Prevention of clinical diseaseLung lesionsLee et al., 2004NRUniversity/ResearchNR1NRLung lesions*Lillie et al., 2004NRCommercialNR1NRLung lesions*Lium et al., 1994NRCommercialNR4Endemic diseaseLung lesions §Longtao and Hui, 2008ChinaCommercial20061Endemic diseaseClinical illness, mortalityLopez and Jimenez, 2008SpainCommercialNR8NRLung lesions*Maes et al., 1998BelgiumCommercial19965Endemic diseaseLung lesions Maes et al., 1999BelgiumCommercialNR14Prevention of clinical diseaseLung lesions §Marchioro et al., 2013BelgiumUniversity/ResearchNR1Prevention of clinical diseaseLung lesions §Marco et al., 2004**SpainCommercial2001-20021Endemic diseaseLung lesions §, mortality ****Marco et al., 2004**SpainCommercial2001-20021Endemic diseaseLung lesions §, mortality ****Marco et al., 2010NRCommercialNR1Endemic diseaseLung lesions §Mateusen et al., 2001BelgiumNRNR1Endemic diseaseCough index, lung lesions §, mortalityMateusen et al., 2002NRCommercial 19991Prevention of clinical diseaseLung lesions mortality, Matsumoto et al., 2008JapanCommercialNR3Endemic diseaseLung lesions*Mefford et al., 1983USACommercialNR1Endemic diseaseMortality ****Mettler et al., 2008NRCommercialNR1Endemic diseaseLung lesions*Moore and Suprenant, 2014NRCommercialNR1Endemic diseaseLung lesions, mortalityMorales et al., 2012SpainCommercialNR1Prevention of clinical diseaseLung lesions ****, mortality ****Moreau et al., 2000NRCommercial 19991Endemic diseaseLung lesions*, mortality ****Moreau et al., 2004USANRNR1Endemic diseaseLung lesions*, mortality*Morris and Sanford, 2001CanadaCommercialNR4Prevention of clinical diseaseLung lesions, mortalityNaito, 2014JapanCommercialNR1Prevention of clinical diseaseMortality ****Nigrelli et al., 2004ItalyCommercial NA1Prevention of clinical diseaseLung lesions*Nilubol and Lengkayan, 2006NRCommercialNR1Endemic diseaseMortality*Nymark and Dahl, 2002DenmarkCommercialNR2Endemic diseaseLung lesions*Oh et al., 2013KoreaCommercial20121Endemic diseaseMortality*Okada et al., 1999**JapanCommercialNR1Endemic diseaseLung lesions ?Okada et al., 1999**JapanCommercialNR1Endemic diseaseLung lesionsOkada et al., 1999**JapanCommercialNR1Endemic diseaseLung lesions ?Pabst and Beilage, 2004GermanyCommercialNR2Endemic diseaseMortalityPagot et al., 2017FranceCommercialNR1Endemic diseaseLung lesions, mortalityPallares et al., 2000SpainCommercialNR8Prevention of clinical diseaseLung lesions §Pallares et al., 2001SpainCommercial NR16Prevention of clinical diseaseMortalityPalomo and Fernandez, 2011SpainCommercialNR1Endemic diseaseMortalityPalzer et al., 2015NRUniversity/ResearchNR1Endemic diseaseMortalityPaterson et al., 2000AustraliaCommercialNR1Endemic diseaseLung lesions*Pepovich et al., 2015BulgariaCommercialNR1Endemic diseaseClinical illness ****, lung lesions ****, mortality ****Pijoan et al., 1986USACommercial NR1Endemic diseaseLung lesions ?, mortality ****Pillet et al., 2010FranceCommercialNR1Prevention of clinical diseaseLung lesions ****, mortality ****Pommier et al., 2000aFranceCommercialNR3Prevention of clinical diseaseLung lesions*, mortality*Pommier et al., 2000bFranceCommercialNR3Endemic diseaseLung lesions, mortalityPrevost et al., 1990 NRCommercialNR3Endemic diseaseLung lesions*Procajlo et al., 2010aPolandCommercialNR1Prevention of clinical diseaseClinical illness, lung lesions ?, mortalityProcaj?o et al., 2010bNRCommercialNR1Prevention of clinical diseaseClinical illness, lung lesions, mortalityRidremont and Volant, 2006FranceCommercialNR4NRLung lesions*Riising, 1980**NRCommercialNR1Endemic diseaseLung lesions§Riising, 1980**NRCommercialNR1Endemic diseaseClinical illness, lung lesions § Riising, 1980**NRCommercialNR1Endemic diseaseClinical illness, lung lesions §Ristow et al., 2002BrazilCommercialNR1Endemic diseaseLung lesions ****Rosales et al., 2008MexicoCommercial2006-20071Endemic diseaseMortalityRosseau et al., 1988CanadaCommercialNR1Prevention of clinical diseaseMortality*Sala et al., 2002ItalyCommercial1999-20001Prevention of clinical diseaseLung lesions*Sanchez et al., 2014SpainCommercial2012-20131Endemic diseaseLung lesions ****Schimmel et al., 1990UKCommercialNR1NRLung lesions*Sibila et al., 2006aNRCommercialNR1Endemic diseaseLung lesions*Sibila et al., 2006bNRCommercialNR1Prevention of clinical diseaseLung lesions*Sibila et al., 2007NRCommercialNR1Endemic diseaseLung lesions §Sibila et al., 2008NRCommercialNR1Endemic diseaseLung lesions*Silva et al., 2002**BrazilCommercialNR1Endemic diseaseLung lesionsSilva et al., 2002**BrazilCommercialNR1Endemic diseaseLung lesions ****Silva et al., 2002**BrazilCommercialNR1Endemic diseaseLung lesions*Sitthicharoenchai et al., 2014NRCommercialNR1Endemic diseaseLung lesions*Siugzdaite and Garlaite, 2002LithuaniaCommercialNR1NRLung lesions §Siugzdaite et al., 2003LithuaniaCommercial NR1Prevention of clinical diseaseLung lesions*Siugzdaite et al., 2005LithuaniaCommercialNR1Endemic diseaseLung lesions*?iug?daite et al., 2006LithuaniaCommercialNR3Prevention of clinical diseaseLung lesions*Smith et al., 2002FranceCommercialNR6Endemic diseaseLung lesions*Stipkovits et al., 2003**NRNRNR1Endemic diseaseLung lesions, mortalityStipkovits et al., 2003**NRNRNR1Endemic diseaseLung lesions, mortalityStraw et al., 1984USANR1981NRPrevention of clinical diseaseLung lesions*Stricker et al., 2011AustriaCommercialNR1Endemic diseaseLung lesions*Stricker et al., 2013AustriaCommercialNR1Prevention of clinical diseaseClinical illness, lung lesions §, mortalitySudeick et al., 2013GermanyCommercial20021NRLung lesions*, mortality*Sun et al., 2014ChinaCommercial20121Endemic diseaseMortalityTassis et al., 2010GreeceCommercialNR1Endemic diseaseClinical illness, lung lesions, mortalityTassis et al., 2012GreeceCommercialNR1Endemic diseaseClinical illness, lung lesions, mortalityTassis et al., 2017GreeceCommercial20101Endemic diseaseClinical illness, lung lesions, mortalityThanawongnuwech et al., 2003ThailandCommercialNR2Endemic diseaseLung lesions*Tremblay and Moore, 2012CanadaCommercialNR1Endemic diseaseLung lesions*, mortalityTzivara et al., 2007**GreeceCommercial2002-20031Endemic diseaseClinical illness, lung lesions §, mortalityTzivara et al., 2007**GreeceCommercial2002-20031Endemic diseaseClinical illness, lung lesions §, mortalityTzivara et al., 2010GreeceCommercialNR2Endemic diseaseLung lesions*Utrera et al., 2000NRCommercialNA1Endemic diseaseLung lesions ****, mortality ****Utrera et al., 2006NRCommercialNRMultiple siteEndemic diseaseMortality ****VanBuren et al., 2001Canada, MexicoNRNRMulti-locationEndemic diseaseMortalityVanNes et al., 2000NetherlandsCommercialNR16Endemic diseaseMortality*Villarreal et al., 2010BelgiumUniversity/ResearchNR1Prevention of clinical diseaseLung lesions*Villarreal et al., 2011BelgiumCommercial20081Endemic diseaseLung lesions §, §§Voisin et al., 2014FranceCommercial 2012-20133Prevention of clinical diseaseClinical illness, mortalityVonderfecht, 1983USACommercialNR2Endemic diseaseMortality*Vraa-Andersen et al., 1994DenmarkCommercialNR5Endemic diseaseLung lesions*Wallgren et al., 2000NRCommercialNR1Endemic diseaseLung lesionsWilson et al., 2012GermanyCommercialNR1Endemic diseaseLung lesions, mortalityWongnarkpet et al., 1999aNew ZealandCommercial1993-19941Endemic diseaseLung lesions §, mortalityWongnarkpet et al., 1999bNew ZealandCommercial1993-19941Endemic diseaseLung lesions §Zankl et al., 2012GermanyCommercialNRMulti-siteEndemic diseaseLung lesions** Reported eligible outcomes, but were not able to extract data for other reason** Multiple trials or farms reported as separate trials within the same publication*** Vaccination of sows**** One or more treatment arms not described in sufficient detail to categorize into intervention group? Zero cells (no events) or all animals experienced the event, precluding calculation of relative risk?? Does not link to network (no intervention arms common with intervention arms in another trial)§ Provided lung lesions specific to a pathogen (NB: non-specific lung lesions used in NMA)§§ Provided non-specific lung lesions as a continuous scaleSupplementary table 2. Risk ratio comparison for morbidity as an outcome for all vaccines assessed in a network meta-analysis of the efficacy of bacterial vaccines for respiratory disease in swine. The upper right hand section of the table represents the risk ratio between the numerator (upper left treatment) and denominator (lower right treatment). The lower left section of the table represents the 95% credibility interval for the comparison, with the rows and columns reversed. Supplementary table 3. Mean ranking of vaccine interventions for morbidity as an outcome from a Bayesian network meta-analysis of the efficacy of bacterial vaccines for respiratory disease in swine. Mean rank, standard deviation and quartile rankings are shown.InterventionMean rankSD2.50%50%97.50%Inglevac HP-11.771.68117RepiSure One2.841.56127Respisure and immune stimulant3.982.691312Pleurinord5.4731513Porcilis M Hyo ID ONCE8.122.484814Stellamune Mono Injection8.834.152817Suvaxyn M Hyo mono11.034.1731118Pneuroguard11.274.5131218Porcilis PCV M Hyo11.654.4231218Porcillis M hyo and PRRS11.84.1241218Hyogen11.854.4331218Non-active control12.481.8891316Porcilis APP13.34.9621518Ingelvac M Hyo13.323.7451418ThoroVAX VET13.473.6751418Supplementary Table 4: Results of the indirect comparisons for the consistency assumption for morbidity. Columns represent posterior means (d) and standard deviations (sd) of the log-odds ratio of vaccine effects calculated using direct evidence (d), all evidence (MTC), and indirect evidence (rest); w and sd_w represent the inconsistency estimate and its standard parisond_dirsd_dird_MTCsd_MTCd_restsd_restWsd_wp_valuePO vs POP-0.192.860.480.580.510.59-0.712.920.81PO vs PP-0.042.860.30.60.310.62-0.352.930.9PO vs SU-0.392.880.370.570.40.58-0.82.940.79POP vs PP0.192.84-0.190.68-0.210.710.42.930.89RE vs REI0.161.920.220.580.230.61-0.072.020.97NAC vs PN-0.092.88-0.10.78-0.10.810.022.991NAC vs PO-0.540.26-0.520.33-0.56NA0.02NANANAC vs POP0.212.88-0.040.67-0.060.690.272.960.93NAC vs PP-0.012.93-0.230.7-0.240.720.233.020.94NAC vs RE-1.560.95-1.620.44-1.640.490.081.070.94NAC vs REI-1.151.7-1.40.66-1.440.720.291.850.88NAC vs ST0.172.9-0.480.69-0.510.710.682.980.82NAC vs SU-0.142.85-0.150.66-0.150.680.012.931NAC vs TH0.281.530.230.620.220.670.061.670.97NAC vs I-0.41.62-0.670.64-0.720.690.321.770.86NAC vs IH-2.262.88-2.250.73-2.250.75-0.012.971NAC vs IM0.21.970.20.620.20.6602.081NAC vs J5-0.052.93-0.040.81-0.040.84-0.013.051NAC vs HY-12.96-0.040.740.030.77-1.033.060.74NAC vs PAP0.3430.351.050.351.12-0.013.21NAC vs PC-0.062.88-0.050.74-0.050.76-0.012.981NAC vs PL-1.031.42-1.030.55-1.030.601.541I vs RE0.591.8-0.950.57-1.120.61.711.90.37I vs REI0.751.79-0.730.65-0.960.71.711.920.37IM vs TH-0.121.90.030.620.040.66-0.162.010.94J5 vs PN0.042.89-0.060.8-0.070.830.113.010.97HY vs ST-1.042.9-0.440.72-0.40.74-0.642.990.83Supplementary table 5. Risk ratio comparison for mortality as an outcome for all vaccines assessed in a network meta-analysis of the efficacy of bacterial vaccines for respiratory disease in swine. The upper right hand section of the table represents the risk ratio between the numerator (upper left treatment) and denominator (lower right treatment). The lower left section of the table represents the 95% credibility interval for the comparison, with the rows and columns reversed. Supplementary table 6. Mean ranking of vaccine interventions for mortality as an outcome from a Bayesian network meta-analysis of the efficacy of bacterial vaccines for respiratory disease in swine. Mean rank, standard deviation and quartile rankings are shown.InterventionMean rankSD2.50%50%97.50%Inglevac HP-12.081.42126Porcilis APP3.981.98149Respisure and immune stimulant5.644.491418Coglapix8.355.062721Porcillis M hyo and PRRS8.439.771434Flexcombo and circovirus8.894.512820Porcillus APP and Tiamulin9.934.383920Porcilis Glasser and PRRS10.136.662928Porcilis Glasser10.154.3531020Pneuroguard13.437.0231231Respisure and Tiamulin14.934.5471425Stellamune and lincomycin16.039.8821434Stellamune Mono Injection17.353.5111725Respisure and lincomycin19.588.6151934MycoFLEX and Circovirus19.85.9919323Flex20.287.4272034SPRINTVAC21.277.7972134Respisure and PCV vaccine (any)21.329.6742135Suvaxyn M hyo and lincomycin22.156.8292234Porcilis PCV M Hyo22.295.68122233RepiSure One22.764.83142332M+PAC25.558.7572835Porcilis M Hyo ID ONCE25.914.02182633Ingelvac M Hyo26.033.93182633Parasail26.185.57142734Hyogen27.265.14162834Non-active control27.372.3422.9752732Suvaxyn M Hyo mono27.584.32182834ThoroVAX VET28.294.92173034Supplementary Table 7: Results of the indirect comparisons for the consistency assumption for mortality. Columns represent posterior means (d) and standard deviations (sd) of the log-odds ratio of vaccine effects calculated using direct evidence (d), all evidence (MTC), and indirect evidence (rest); w and sd_w represent the inconsistency estimate and its standard parisond_dirsd_dird_MTCsd_MTCd_restsd_restwsd_wp_valueL vs RE0.012.880.560.430.570.43-0.562.910.85L vs REL-0.432.940.380.520.40.53-0.832.990.78L vs ST-0.542.980.290.430.310.44-0.853.010.78L vs STL-0.032.970.110.640.120.66-0.143.040.96M vs ST-0.492.91-0.490.54-0.50.550.012.971MP vs PO-0.032.97-0.090.56-0.090.570.063.020.99MYC vs PC-0.241.710.130.310.140.32-0.381.740.82MYC vs REP0.112.880.090.580.090.590.022.940.99NAC vs L-0.61.68-0.750.49-0.770.510.171.760.92NAC vs MP0.22.940.040.620.030.640.183.010.95NAC vs MYC-0.180.83-0.350.34-0.380.370.20.910.82NAC vs PA02.89-0.020.29-0.020.290.032.90.99NAC vs PAP-1.440.93-1.60.27-1.610.280.180.980.86NAC vs PAT-0.962.89-0.970.33-0.970.340.012.911NAC vs PC-0.131.02-0.220.29-0.230.30.11.060.92NAC vs PG-0.942.89-0.950.32-0.950.330.012.911NAC vs CO-1.142.93-1.150.45-1.150.460.012.961NAC vs PGP-1.032.88-1.030.54-1.030.5502.931NAC vs PN-0.732.92-0.770.48-0.770.490.042.970.99NAC vs PO-0.060.31-0.050.16-0.050.19-0.010.360.97NAC vs POP-0.663.23-1.551.19-1.691.281.033.480.77NAC vs RE-0.290.3-0.20.23-0.060.37-0.230.470.63NAC vs REI-1.542.93-1.490.55-1.490.56-0.052.980.99NAC vs REL-0.662.92-0.380.54-0.370.55-0.292.970.92NAC vs RET-0.631.34-0.620.26-0.620.27-0.011.371NAC vs ST-0.380.45-0.460.17-0.470.190.090.490.86NAC vs STL0.022.99-0.640.73-0.680.750.73.080.82NAC vs SU0.030.570.030.20.030.2100.61NAC vs T-0.851.34-0.850.27-0.850.28-0.011.371NAC vs TH00.680.090.270.10.3-0.10.740.89NAC vs FLCI-0.212.95-1.070.38-1.090.390.882.980.77NAC vs HY0.031.390.030.270.030.2701.411NAC vs I-0.10.92-0.090.29-0.080.31-0.020.970.99NAC vs IH-2.062.87-2.050.36-2.050.37-0.012.91NAC vs IM-0.050.15-0.050.16-0.06NA0.01NANANAC vs J5-1.063-1.090.63-1.10.640.033.070.99PO vs POP1.813.19-1.51.12-1.961.193.773.410.27PO vs SU0.172.850.080.180.080.180.092.860.97RE vs REI1.352.87-1.30.48-1.370.482.732.910.35RE vs REL-0.422.96-0.180.47-0.180.47-0.252.990.93RE vs SP-0.092.91-0.080.39-0.080.4-0.012.941RET vs T0.241.37-0.230.27-0.250.270.491.40.72ST vs STL0.532.98-0.180.66-0.220.670.753.060.81FL vs MYC-0.012.87-0.020.4-0.020.402.91FLCI vs MYC0.022.980.720.360.730.36-0.7130.81FLCI vs CF1.982.991.980.781.980.810.013.11FLCI vs IM1.272.871.030.331.020.330.252.890.93HY vs ST-0.522.93-0.490.23-0.490.23-0.032.940.99I vs RE0.120.99-0.110.27-0.130.280.251.020.81I vs REI1.382.93-1.410.47-1.480.482.862.970.34IM vs RE0.161.65-0.150.21-0.150.210.321.670.85IM vs TH-0.081.40.130.240.140.24-0.221.420.88J5 vs PN-0.342.940.330.570.350.58-0.72.990.82Supplementary table 8. Risk ratio comparison for mortality as an outcome for all vaccines assessed in a network meta-analysis of the efficacy of bacterial vaccines for respiratory disease in swine. The upper right hand section of the table represents the risk ratio between the numerator (upper left treatment) and denominator (lower right treatment). The lower left section of the table represents the 95% credibility interval for the comparison, with the rows and columns reversed. Supplementary table 9. Mean ranking of vaccine interventions for non-specific lung lesions as an outcome from a Bayesian network meta-analysis of the efficacy of bacterial vaccines for respiratory disease in swine. Mean rank, standard deviation and quartile rankings are shown.InterventionMeanSD2.50%50%97.50%Respisure and Tiamulin1.881.63117Ingelvac M Hyo3.652.81312Respisure and immune stimulant6.553.831616RepiSure One6.82.953614SPRINTVAC95.521821Mycobuster10.565.3621021Hyoresp10.615.9911022Hyogen10.985.2221021Suvaxyn M Hyo mono11.24.1941120Porcilis PCV M Hyo11.554.1241120Vaxsafe MHP11.575.1431121Porcilis M Hyo ID ONCE11.863.6451219Respisure and PCV vaccine (any)12.626.1821322MycoFLEX and Circovirus12.824.8541321Porcilis APP, MSD12.844.1451320Stellamune Mono Injection13.572.6781418Stellamune and lincomycin17.464.0471922Ingelvac APPX and Circovirus17.874.2271922Non-active control17.941.69141821Supplementary Table 10: Results of the indirect comparisons for the consistency assumption for the presence / absence of non-specific lung lesions. Columns represent posterior means (d) and standard deviations (sd) of the log-odds ratio of vaccine effects calculated using direct evidence (d), all evidence (MTC), and indirect evidence (rest); w and sd_w represent the inconsistency estimate and its standard parisond_dirsd_dird_MTCsd_MTCd_restsd_restwsd_wp_valuePO vs ST-0.022.90.230.440.240.45-0.262.930.93RE vs REI0.031.71-0.090.75-0.120.840.151.910.94RE vs SP0.272.930.280.980.281.04-0.013.111RET vs T-0.791.550.790.821.390.96-2.181.820.23ST vs STL-0.532.940.70.690.770.71-1.33.030.67NAC vs PAP-0.691.51-0.690.6-0.690.65-0.011.641NAC vs PC-0.861.38-0.870.64-0.870.730.011.560.99NAC vs PO-0.941.31-0.820.5-0.80.55-0.141.420.92NAC vs RE-1.671.59-1.690.65-1.70.710.031.750.99NAC vs REI-2.12.96-1.780.83-1.750.86-0.353.080.91NAC vs RET-3.221.67-3.240.81-3.250.930.031.910.99NAC vs ST-0.560.72-0.590.34-0.60.380.040.820.96NAC vs STL0.252.940.110.80.10.830.163.060.96NAC vs SU-0.91.39-0.930.62-0.940.70.041.560.98NAC vs T-2.471.63-2.460.82-2.450.94-0.021.890.99NAC vs VM-0.912.9-0.890.86-0.890.9-0.023.030.99NAC vs I0.152.950.450.930.480.98-0.333.110.92NAC vs IAC0.222.920.220.90.220.95-0.013.071NAC vs L0.552.910.40.790.380.830.163.030.96NAC vs MY-1.082.92-1.060.93-1.060.98-0.023.080.99NAC vs MYC-0.662.91-0.690.85-0.690.890.033.050.99NAC vs HR-1.072.99-1.081.12-1.081.2103.221HY vs ST0.382.90.390.790.390.82-0.013.011I vs RE2.322.92-2.140.83-2.530.864.853.040.11I vs REI2.252.91-2.230.88-2.680.934.943.050.11IAC vs PC1.122.95-1.10.8-1.270.842.393.060.44IM vs RE0.811.750.810.80.810.901.971L vs ST0.862.93-0.990.69-1.10.711.953.020.52L vs STL0.292.91-0.290.8-0.340.830.633.030.84MYC vs PC0.162.89-0.180.77-0.210.80.3730.9MYC vs REP-0.012.91-0.021.09-0.021.170.023.141Supplementary table 11: Grade summary of evidence for morbidity as an outcome in a network meta-analysis of bacterial vaccines to prevent respiratory disease in swine. The comparisons shown represent comparisons between eligible vaccines; comparisons where the number of contributing studies is equal to zero represent indirect evidence. Comparison# of studiesRandomizationBlindingImprecisionHeterogeneityHY:ST1Major concernsNo concernsMajor concernsNo concernsIM:TH2No concernsSome concernsMajor concernsNo concernsPO:POP1Major concernsSome concernsSome concernsSome concernsPO:SU1Some concernsSome concernsSome concernsSome concernsRE:REI2Major concernsMajor concernsMajor concernsNo concernsHY:IH0Some concernsMajor concernsNo concernsNo concernsHY:IM0No concernsSome concernsMajor concernsNo concernsHY:PAP0Some concernsNo concernsMajor concernsNo concernsHY:PC0No concernsNo concernsMajor concernsNo concernsHY:PL0Major concernsMajor concernsSome concernsNo concernsHY:PN0Some concernsMajor concernsMajor concernsNo concernsHY:PO0Some concernsSome concernsSome concernsSome concernsHY:POP0Major concernsSome concernsMajor concernsNo concernsHY:RE0Major concernsMajor concernsSome concernsNo concernsHY:REI0Major concernsMajor concernsSome concernsSome concernsHY:SU0Some concernsSome concernsMajor concernsNo concernsHY:TH0No concernsSome concernsMajor concernsNo concernsIH:IM0No concernsSome concernsNo concernsNo concernsIH:PAP0Some concernsNo concernsNo concernsNo concernsIH:PC0No concernsNo concernsNo concernsNo concernsIH:PL0Some concernsMajor concernsNo concernsSome concernsIH:PN0Some concernsMajor concernsNo concernsNo concernsIH:PO0Some concernsMajor concernsNo concernsNo concernsIH:POP0Major concernsSome concernsNo concernsNo concernsIH:RE0Major concernsMajor concernsNo concernsSome concernsIH:REI0Major concernsMajor concernsSome concernsNo concernsIH:ST0Some concernsMajor concernsNo concernsNo concernsIH:SU0Some concernsSome concernsNo concernsNo concernsIH:TH0No concernsSome concernsNo concernsNo concernsIM:PAP0No concernsSome concernsMajor concernsNo concernsIM:PC0No concernsSome concernsMajor concernsNo concernsIM:PL0No concernsSome concernsSome concernsSome concernsIM:PN0No concernsSome concernsMajor concernsNo concernsIM:PO0No concernsSome concernsMajor concernsNo concernsIM:POP0No concernsSome concernsMajor concernsNo concernsIM:RE0No concernsSome concernsSome concernsSome concernsIM:REI0Major concernsMajor concernsMajor concernsNo concernsIM:ST0No concernsSome concernsMajor concernsNo concernsIM:SU0No concernsSome concernsMajor concernsNo concernsPAP:PC0No concernsNo concernsMajor concernsNo concernsPAP:PL0Some concernsNo concernsMajor concernsNo concernsPAP:PN0Some concernsMajor concernsMajor concernsNo concernsPAP:PO0Some concernsNo concernsMajor concernsNo concernsPAP:POP0Major concernsSome concernsMajor concernsNo concernsPAP:RE0Major concernsMajor concernsMajor concernsNo concernsPAP:REI0Major concernsMajor concernsMajor concernsNo concernsPAP:ST0Some concernsNo concernsMajor concernsNo concernsPAP:SU0Some concernsSome concernsMajor concernsNo concernsPAP:TH0No concernsSome concernsMajor concernsNo concernsPC:PL0No concernsNo concernsSome concernsNo concernsPC:PN0Some concernsMajor concernsMajor concernsNo concernsPC:PO0No concernsNo concernsSome concernsSome concernsPC:POP0Major concernsSome concernsMajor concernsNo concernsPC:RE0Major concernsMajor concernsSome concernsNo concernsPC:REI0Major concernsMajor concernsSome concernsSome concernsPC:ST0Some concernsNo concernsMajor concernsNo concernsPC:SU0Some concernsSome concernsMajor concernsNo concernsPC:TH0No concernsSome concernsMajor concernsNo concernsPL:PN0Some concernsMajor concernsSome concernsSome concernsPL:PO0Major concernsMajor concernsMajor concernsNo concernsPL:POP0Major concernsSome concernsSome concernsSome concernsPL:RE0Major concernsMajor concernsMajor concernsNo concernsPL:REI0Major concernsMajor concernsMajor concernsNo concernsPL:ST0Major concernsMajor concernsMajor concernsNo concernsPL:SU0Some concernsSome concernsSome concernsSome concernsPL:TH0No concernsSome concernsSome concernsSome concernsPN:PO0Some concernsMajor concernsMajor concernsNo concernsPN:POP0Some concernsSome concernsMajor concernsNo concernsPN:RE0Some concernsMajor concernsSome concernsSome concernsPN:REI0Major concernsMajor concernsSome concernsSome concernsPN:ST0Some concernsMajor concernsMajor concernsNo concernsPN:SU0Some concernsMajor concernsMajor concernsNo concernsPN:TH0No concernsSome concernsMajor concernsNo concernsPO:RE0Major concernsMajor concernsMajor concernsNo concernsPO:REI0Major concernsMajor concernsMajor concernsNo concernsPO:ST0Some concernsMajor concernsMajor concernsNo concernsPO:TH0No concernsSome concernsSome concernsSome concernsPOP:RE0Major concernsSome concernsSome concernsSome concernsPOP:REI0Major concernsMajor concernsSome concernsSome concernsPOP:ST0Major concernsSome concernsMajor concernsNo concernsPOP:SU0Major concernsSome concernsMajor concernsNo concernsPOP:TH0Major concernsSome concernsMajor concernsNo concernsRE:ST0Major concernsMajor concernsMajor concernsNo concernsRE:SU0Major concernsMajor concernsSome concernsSome concernsRE:TH0No concernsSome concernsSome concernsSome concernsREI:ST0Major concernsMajor concernsMajor concernsNo concernsREI:SU0Major concernsMajor concernsSome concernsSome concernsREI:TH0Major concernsMajor concernsSome concernsSome concernsST:SU0Some concernsSome concernsMajor concernsNo concernsST:TH0No concernsSome concernsMajor concernsNo concernsSU:TH0No concernsSome concernsMajor concernsNo concernsSupplementary table 12: Grade summary of evidence for mortality as an outcome in a network meta-analysis of bacterial vaccines to prevent respiratory disease in swine. The comparisons shown represent comparisons between eligible vaccines; comparisons where the number of contributing studies is equal to zero represent indirect evidence. Comparison# of studiesRandomizationBlindingImprecisionHeterogeneityFL:MYC1Major concernsMajor concernsMajor concernsNo concernsFLCI:IM1Some concernsMajor concernsNo concernsSome concernsFLCI:MYC1Some concernsMajor concernsSome concernsSome concernsHY:ST1Major concernsSome concernsSome concernsNo concernsIM:RE2Some concernsMajor concernsMajor concernsNo concernsIM:TH2No concernsSome concernsMajor concernsNo concernsMP:PO1No concernsNo concernsMajor concernsNo concernsMYC:PC2Some concernsMajor concernsMajor concernsNo concernsMYC:REP1Some concernsMajor concernsMajor concernsNo concernsPO:POP1No concernsMajor concernsMajor concernsNo concernsPO:SU1Some concernsSome concernsMajor concernsNo concernsRE:REI1Major concernsMajor concernsNo concernsSome concernsRE:REL1No concernsSome concernsMajor concernsNo concernsRE:SP1Some concernsMajor concernsMajor concernsNo concernsST:STL1Some concernsNo concernsMajor concernsNo concernsCO:FL0Major concernsMajor concernsMajor concernsNo concernsCO:FLCI0Major concernsMajor concernsMajor concernsNo concernsCO:HY0Major concernsMajor concernsSome concernsNo concernsCO:IH0Some concernsMajor concernsSome concernsSome concernsCO:IM0Major concernsMajor concernsNo concernsSome concernsCO:MP0Major concernsNo concernsMajor concernsNo concernsCO:MYC0Major concernsMajor concernsMajor concernsNo concernsCO:PA0Some concernsMajor concernsSome concernsNo concernsCO:PAP0Major concernsMajor concernsMajor concernsNo concernsCO:PAT0Major concernsMajor concernsMajor concernsNo concernsCO:PC0Major concernsMajor concernsSome concernsNo concernsCO:PG0Major concernsMajor concernsMajor concernsNo concernsCO:PGP0No concernsNo concernsMajor concernsNo concernsCO:PN0Some concernsMajor concernsMajor concernsNo concernsCO:PO0Major concernsMajor concernsSome concernsNo concernsCO:POP0Major concernsMajor concernsMajor concernsNo concernsCO:RE0Major concernsMajor concernsSome concernsNo concernsCO:REI0Major concernsMajor concernsMajor concernsNo concernsCO:REL0No concernsMajor concernsMajor concernsNo concernsCO:REP0Some concernsMajor concernsMajor concernsNo concernsCO:RET0Major concernsMajor concernsMajor concernsNo concernsCO:SP0Some concernsMajor concernsMajor concernsNo concernsCO:ST0Major concernsMajor concernsSome concernsSome concernsCO:STL0Some concernsMajor concernsMajor concernsNo concernsCO:SU0Major concernsMajor concernsNo concernsSome concernsCO:SUL0Some concernsMajor concernsSome concernsSome concernsCO:TH0No concernsMajor concernsNo concernsSome concernsFL:FLCI0Major concernsMajor concernsMajor concernsNo concernsFL:HY0Major concernsMajor concernsMajor concernsNo concernsFL:IH0Some concernsMajor concernsNo concernsNo concernsFL:IM0Some concernsMajor concernsMajor concernsNo concernsFL:MP0Some concernsMajor concernsMajor concernsNo concernsFL:PA0Some concernsMajor concernsMajor concernsNo concernsFL:PAP0Major concernsMajor concernsNo concernsNo concernsFL:PAT0Major concernsMajor concernsMajor concernsNo concernsFL:PC0Some concernsMajor concernsMajor concernsNo concernsFL:PG0Major concernsMajor concernsMajor concernsNo concernsFL:PGP0Major concernsMajor concernsMajor concernsNo concernsFL:PN0Some concernsMajor concernsMajor concernsNo concernsFL:PO0Some concernsMajor concernsMajor concernsNo concernsFL:POP0Some concernsMajor concernsMajor concernsNo concernsFL:RE0Some concernsMajor concernsMajor concernsNo concernsFL:REI0Major concernsMajor concernsSome concernsSome concernsFL:REL0Major concernsMajor concernsMajor concernsNo concernsFL:REP0Some concernsMajor concernsMajor concernsNo concernsFL:RET0Major concernsMajor concernsMajor concernsNo concernsFL:SP0Some concernsMajor concernsMajor concernsNo concernsFL:ST0Major concernsMajor concernsMajor concernsNo concernsFL:STL0Some concernsMajor concernsMajor concernsNo concernsFL:SU0Some concernsMajor concernsMajor concernsNo concernsFL:SUL0Some concernsMajor concernsMajor concernsNo concernsFL:TH0No concernsMajor concernsMajor concernsNo concernsFLCI:HY0Some concernsMajor concernsNo concernsSome concernsFLCI:IH0Some concernsMajor concernsSome concernsNo concernsFLCI:MP0No concernsMajor concernsMajor concernsNo concernsFLCI:PA0Some concernsMajor concernsSome concernsNo concernsFLCI:PAP0Some concernsMajor concernsMajor concernsNo concernsFLCI:PAT0Major concernsMajor concernsMajor concernsNo concernsFLCI:PC0Some concernsMajor concernsSome concernsNo concernsFLCI:PG0Major concernsMajor concernsMajor concernsNo concernsFLCI:PGP0No concernsMajor concernsMajor concernsNo concernsFLCI:PN0Some concernsMajor concernsMajor concernsNo concernsFLCI:PO0Some concernsMajor concernsNo concernsSome concernsFLCI:POP0No concernsMajor concernsMajor concernsNo concernsFLCI:RE0Some concernsMajor concernsSome concernsNo concernsFLCI:REI0Major concernsMajor concernsMajor concernsNo concernsFLCI:REL0No concernsMajor concernsMajor concernsNo concernsFLCI:REP0Some concernsMajor concernsMajor concernsNo concernsFLCI:RET0Major concernsMajor concernsMajor concernsNo concernsFLCI:SP0Some concernsMajor concernsMajor concernsNo concernsFLCI:ST0Some concernsMajor concernsSome concernsSome concernsFLCI:STL0Some concernsMajor concernsMajor concernsNo concernsFLCI:SU0Some concernsMajor concernsNo concernsSome concernsFLCI:SUL0Some concernsMajor concernsSome concernsNo concernsFLCI:TH0No concernsMajor concernsNo concernsNo concernsHY:IH0Some concernsMajor concernsNo concernsNo concernsHY:IM0Some concernsSome concernsMajor concernsNo concernsHY:MP0No concernsNo concernsMajor concernsNo concernsHY:MYC0Some concernsMajor concernsMajor concernsNo concernsHY:PA0Some concernsMajor concernsMajor concernsNo concernsHY:PAP0Major concernsMajor concernsNo concernsNo concernsHY:PAT0Major concernsMajor concernsNo concernsSome concernsHY:PC0Some concernsMajor concernsMajor concernsNo concernsHY:PG0Major concernsMajor concernsNo concernsSome concernsHY:PGP0No concernsNo concernsSome concernsNo concernsHY:PN0Some concernsMajor concernsMajor concernsNo concernsHY:PO0Some concernsSome concernsMajor concernsNo concernsHY:POP0No concernsMajor concernsMajor concernsNo concernsHY:RE0Some concernsMajor concernsMajor concernsNo concernsHY:REI0Major concernsMajor concernsNo concernsNo concernsHY:REL0No concernsSome concernsMajor concernsNo concernsHY:REP0Some concernsMajor concernsMajor concernsNo concernsHY:RET0Major concernsMajor concernsSome concernsNo concernsHY:SP0Some concernsMajor concernsMajor concernsNo concernsHY:STL0Some concernsNo concernsMajor concernsNo concernsHY:SU0Some concernsSome concernsMajor concernsNo concernsHY:SUL0Some concernsMajor concernsMajor concernsNo concernsHY:TH0No concernsSome concernsMajor concernsNo concernsIH:IM0Some concernsMajor concernsNo concernsNo concernsIH:MP0Some concernsNo concernsNo concernsNo concernsIH:MYC0Some concernsMajor concernsNo concernsNo concernsIH:PA0Some concernsMajor concernsNo concernsNo concernsIH:PAP0Some concernsMajor concernsMajor concernsNo concernsIH:PAT0Some concernsMajor concernsSome concernsNo concernsIH:PC0Some concernsMajor concernsNo concernsNo concernsIH:PG0Some concernsMajor concernsNo concernsSome concernsIH:PGP0No concernsNo concernsSome concernsSome concernsIH:PN0Some concernsMajor concernsSome concernsNo concernsIH:PO0Some concernsMajor concernsNo concernsNo concernsIH:POP0Some concernsMajor concernsMajor concernsNo concernsIH:RE0Some concernsMajor concernsNo concernsNo concernsIH:REI0Some concernsMajor concernsMajor concernsNo concernsIH:REL0Some concernsMajor concernsNo concernsNo concernsIH:REP0Some concernsMajor concernsNo concernsNo concernsIH:RET0Major concernsMajor concernsNo concernsNo concernsIH:SP0Some concernsMajor concernsNo concernsNo concernsIH:ST0Some concernsMajor concernsNo concernsNo concernsIH:STL0Some concernsMajor concernsSome concernsSome concernsIH:SU0Some concernsMajor concernsNo concernsNo concernsIH:SUL0Some concernsMajor concernsNo concernsNo concernsIH:TH0Some concernsMajor concernsNo concernsNo concernsIM:MP0No concernsNo concernsMajor concernsNo concernsIM:MYC0Some concernsMajor concernsMajor concernsNo concernsIM:PA0Some concernsMajor concernsMajor concernsNo concernsIM:PAP0Some concernsMajor concernsNo concernsNo concernsIM:PAT0Major concernsMajor concernsNo concernsSome concernsIM:PC0Some concernsMajor concernsMajor concernsNo concernsIM:PG0Major concernsMajor concernsNo concernsSome concernsIM:PGP0No concernsNo concernsSome concernsNo concernsIM:PN0Some concernsMajor concernsMajor concernsNo concernsIM:PO0Some concernsSome concernsMajor concernsNo concernsIM:POP0No concernsMajor concernsMajor concernsNo concernsIM:REI0Major concernsMajor concernsNo concernsNo concernsIM:REL0No concernsSome concernsMajor concernsNo concernsIM:REP0Some concernsMajor concernsMajor concernsNo concernsIM:RET0Major concernsMajor concernsSome concernsNo concernsIM:SP0Some concernsMajor concernsMajor concernsNo concernsIM:ST0No concernsMajor concernsSome concernsNo concernsIM:STL0Some concernsNo concernsMajor concernsNo concernsIM:SU0Some concernsSome concernsMajor concernsNo concernsIM:SUL0Some concernsMajor concernsMajor concernsNo concernsMP:MYC0Some concernsNo concernsMajor concernsNo concernsMP:PA0Some concernsNo concernsMajor concernsNo concernsMP:PAP0No concernsNo concernsNo concernsNo concernsMP:PAT0Major concernsNo concernsMajor concernsNo concernsMP:PC0No concernsNo concernsMajor concernsNo concernsMP:PG0Major concernsNo concernsMajor concernsNo concernsMP:PGP0No concernsNo concernsMajor concernsNo concernsMP:PN0Some concernsMajor concernsMajor concernsNo concernsMP:POP0No concernsNo concernsMajor concernsNo concernsMP:RE0No concernsNo concernsMajor concernsNo concernsMP:REI0Major concernsMajor concernsSome concernsNo concernsMP:REL0No concernsNo concernsMajor concernsNo concernsMP:REP0Some concernsMajor concernsMajor concernsNo concernsMP:RET0Major concernsMajor concernsMajor concernsNo concernsMP:SP0Some concernsMajor concernsMajor concernsNo concernsMP:ST0No concernsNo concernsMajor concernsNo concernsMP:STL0Some concernsNo concernsMajor concernsNo concernsMP:SU0No concernsNo concernsMajor concernsNo concernsMP:SUL0Some concernsNo concernsMajor concernsNo concernsMP:TH0No concernsSome concernsMajor concernsNo concernsMYC:PA0Some concernsMajor concernsMajor concernsNo concernsMYC:PAP0Some concernsMajor concernsNo concernsNo concernsMYC:PAT0Major concernsMajor concernsMajor concernsNo concernsMYC:PG0Major concernsMajor concernsMajor concernsNo concernsMYC:PGP0No concernsNo concernsMajor concernsNo concernsMYC:PN0Some concernsMajor concernsMajor concernsNo concernsMYC:PO0Some concernsMajor concernsMajor concernsNo concernsMYC:POP0Some concernsMajor concernsMajor concernsNo concernsMYC:RE0Some concernsMajor concernsMajor concernsNo concernsMYC:REI0Some concernsMajor concernsSome concernsNo concernsMYC:REL0Some concernsSome concernsMajor concernsNo concernsMYC:RET0Major concernsMajor concernsMajor concernsNo concernsMYC:SP0Some concernsMajor concernsMajor concernsNo concernsMYC:ST0Some concernsMajor concernsMajor concernsNo concernsMYC:STL0Some concernsMajor concernsMajor concernsNo concernsMYC:SU0Some concernsMajor concernsMajor concernsNo concernsMYC:SUL0Some concernsMajor concernsMajor concernsNo concernsMYC:TH0No concernsSome concernsMajor concernsNo concernsPA:PAP0Some concernsMajor concernsNo concernsNo concernsPA:PAT0Some concernsMajor concernsSome concernsNo concernsPA:PC0Some concernsMajor concernsMajor concernsNo concernsPA:PG0Some concernsMajor concernsSome concernsNo concernsPA:PGP0No concernsNo concernsSome concernsNo concernsPA:PN0Some concernsMajor concernsMajor concernsNo concernsPA:PO0Some concernsMajor concernsMajor concernsNo concernsPA:POP0Some concernsMajor concernsMajor concernsNo concernsPA:RE0Some concernsMajor concernsMajor concernsNo concernsPA:REI0Some concernsMajor concernsNo concernsNo concernsPA:REL0Some concernsMajor concernsMajor concernsNo concernsPA:REP0Some concernsMajor concernsMajor concernsNo concernsPA:RET0Major concernsMajor concernsSome concernsSome concernsPA:SP0Some concernsMajor concernsMajor concernsNo concernsPA:ST0Some concernsMajor concernsSome concernsSome concernsPA:STL0Some concernsMajor concernsMajor concernsNo concernsPA:SU0Some concernsMajor concernsMajor concernsNo concernsPA:SUL0Some concernsMajor concernsMajor concernsNo concernsPA:TH0Some concernsMajor concernsMajor concernsNo concernsPAP:PAT0Major concernsMajor concernsSome concernsSome concernsPAP:PC0Some concernsMajor concernsNo concernsNo concernsPAP:PG0Major concernsMajor concernsSome concernsNo concernsPAP:PGP0No concernsNo concernsMajor concernsNo concernsPAP:PN0Some concernsMajor concernsSome concernsSome concernsPAP:PO0Some concernsMajor concernsNo concernsNo concernsPAP:POP0No concernsMajor concernsMajor concernsNo concernsPAP:RE0Some concernsMajor concernsNo concernsNo concernsPAP:REI0Major concernsMajor concernsMajor concernsNo concernsPAP:REL0No concernsMajor concernsSome concernsNo concernsPAP:REP0Some concernsMajor concernsSome concernsNo concernsPAP:RET0Major concernsMajor concernsNo concernsSome concernsPAP:SP0Some concernsMajor concernsNo concernsNo concernsPAP:ST0Major concernsMajor concernsNo concernsNo concernsPAP:STL0Some concernsMajor concernsMajor concernsNo concernsPAP:SU0Some concernsMajor concernsNo concernsNo concernsPAP:SUL0Some concernsMajor concernsNo concernsNo concernsPAP:TH0No concernsMajor concernsNo concernsNo concernsPAT:PC0Major concernsMajor concernsSome concernsNo concernsPAT:PG0Major concernsMajor concernsMajor concernsNo concernsPAT:PGP0No concernsNo concernsMajor concernsNo concernsPAT:PN0Some concernsMajor concernsMajor concernsNo concernsPAT:PO0Major concernsMajor concernsNo concernsSome concernsPAT:POP0Major concernsMajor concernsMajor concernsNo concernsPAT:RE0Major concernsMajor concernsSome concernsNo concernsPAT:REI0Major concernsMajor concernsMajor concernsNo concernsPAT:REL0No concernsMajor concernsMajor concernsNo concernsPAT:REP0Some concernsMajor concernsMajor concernsNo concernsPAT:RET0Major concernsMajor concernsMajor concernsNo concernsPAT:SP0Some concernsMajor concernsMajor concernsNo concernsPAT:ST0Major concernsMajor concernsSome concernsSome concernsPAT:STL0Some concernsMajor concernsMajor concernsNo concernsPAT:SU0Major concernsMajor concernsNo concernsSome concernsPAT:SUL0Some concernsMajor concernsSome concernsSome concernsPAT:TH0No concernsMajor concernsNo concernsSome concernsPC:PG0Major concernsMajor concernsSome concernsNo concernsPC:PGP0No concernsNo concernsMajor concernsNo concernsPC:PN0Some concernsMajor concernsMajor concernsNo concernsPC:PO0Some concernsNo concernsMajor concernsNo concernsPC:POP0No concernsMajor concernsMajor concernsNo concernsPC:RE0Some concernsMajor concernsMajor concernsNo concernsPC:REI0Major concernsMajor concernsSome concernsNo concernsPC:REL0No concernsSome concernsMajor concernsNo concernsPC:REP0Some concernsMajor concernsMajor concernsNo concernsPC:RET0Major concernsMajor concernsMajor concernsNo concernsPC:SP0Some concernsMajor concernsMajor concernsNo concernsPC:ST0Some concernsMajor concernsMajor concernsNo concernsPC:STL0Some concernsNo concernsMajor concernsNo concernsPC:SU0Some concernsNo concernsMajor concernsNo concernsPC:SUL0Some concernsMajor concernsMajor concernsNo concernsPC:TH0No concernsSome concernsMajor concernsNo concernsPG:PGP0No concernsNo concernsMajor concernsNo concernsPG:PN0Some concernsMajor concernsMajor concernsNo concernsPG:PO0Major concernsMajor concernsNo concernsSome concernsPG:POP0Major concernsMajor concernsMajor concernsNo concernsPG:RE0Major concernsMajor concernsSome concernsNo concernsPG:REI0Major concernsMajor concernsMajor concernsNo concernsPG:REL0No concernsMajor concernsMajor concernsNo concernsPG:REP0Some concernsMajor concernsMajor concernsNo concernsPG:RET0Major concernsMajor concernsMajor concernsNo concernsPG:SP0Some concernsMajor concernsMajor concernsNo concernsPG:ST0Major concernsMajor concernsSome concernsSome concernsPG:STL0Some concernsMajor concernsMajor concernsNo concernsPG:SU0Major concernsMajor concernsNo concernsSome concernsPG:SUL0Some concernsMajor concernsSome concernsSome concernsPG:TH0No concernsMajor concernsNo concernsSome concernsPGP:PN0Some concernsMajor concernsMajor concernsNo concernsPGP:PO0No concernsNo concernsSome concernsNo concernsPGP:POP0No concernsNo concernsMajor concernsNo concernsPGP:RE0No concernsMajor concernsMajor concernsNo concernsPGP:REI0Major concernsMajor concernsMajor concernsNo concernsPGP:REL0No concernsSome concernsMajor concernsNo concernsPGP:REP0Some concernsMajor concernsMajor concernsNo concernsPGP:RET0Major concernsMajor concernsMajor concernsNo concernsPGP:SP0Some concernsMajor concernsMajor concernsNo concernsPGP:ST0No concernsNo concernsMajor concernsNo concernsPGP:STL0No concernsNo concernsMajor concernsNo concernsPGP:SU0No concernsNo concernsSome concernsNo concernsPGP:SUL0No concernsNo concernsMajor concernsNo concernsPGP:TH0No concernsSome concernsSome concernsNo concernsPN:PO0Some concernsMajor concernsMajor concernsNo concernsPN:POP0Some concernsMajor concernsMajor concernsNo concernsPN:RE0Some concernsMajor concernsMajor concernsNo concernsPN:REI0Some concernsMajor concernsMajor concernsNo concernsPN:REL0Some concernsMajor concernsMajor concernsNo concernsPN:REP0Some concernsMajor concernsMajor concernsNo concernsPN:RET0Major concernsMajor concernsMajor concernsNo concernsPN:SP0Some concernsMajor concernsMajor concernsNo concernsPN:ST0Some concernsMajor concernsMajor concernsNo concernsPN:STL0Some concernsMajor concernsMajor concernsNo concernsPN:SU0Some concernsMajor concernsSome concernsSome concernsPN:SUL0Some concernsMajor concernsMajor concernsNo concernsPN:TH0Some concernsMajor concernsSome concernsSome concernsPO:RE0Some concernsMajor concernsMajor concernsNo concernsPO:REI0Major concernsMajor concernsNo concernsNo concernsPO:REL0No concernsSome concernsMajor concernsNo concernsPO:REP0Some concernsMajor concernsMajor concernsNo concernsPO:RET0Major concernsMajor concernsSome concernsNo concernsPO:SP0Some concernsMajor concernsMajor concernsNo concernsPO:ST0Some concernsMajor concernsSome concernsNo concernsPO:STL0Some concernsNo concernsMajor concernsNo concernsPO:SUL0Some concernsMajor concernsMajor concernsNo concernsPO:TH0No concernsSome concernsMajor concernsNo concernsPOP:RE0No concernsMajor concernsMajor concernsNo concernsPOP:REI0Major concernsMajor concernsMajor concernsNo concernsPOP:REL0No concernsMajor concernsMajor concernsNo concernsPOP:REP0Some concernsMajor concernsMajor concernsNo concernsPOP:RET0Major concernsMajor concernsMajor concernsNo concernsPOP:SP0Some concernsMajor concernsMajor concernsNo concernsPOP:ST0No concernsMajor concernsMajor concernsNo concernsPOP:STL0Some concernsMajor concernsMajor concernsNo concernsPOP:SU0No concernsMajor concernsMajor concernsNo concernsPOP:SUL0Some concernsMajor concernsMajor concernsNo concernsPOP:TH0No concernsSome concernsMajor concernsNo concernsRE:REP0Some concernsMajor concernsMajor concernsNo concernsRE:RET0Major concernsMajor concernsSome concernsSome concernsRE:ST0Some concernsMajor concernsMajor concernsNo concernsRE:STL0Some concernsMajor concernsMajor concernsNo concernsRE:SU0Some concernsMajor concernsMajor concernsNo concernsRE:SUL0Some concernsMajor concernsMajor concernsNo concernsRE:TH0No concernsSome concernsMajor concernsNo concernsREI:REL0No concernsMajor concernsMajor concernsNo concernsREI:REP0Some concernsMajor concernsMajor concernsNo concernsREI:RET0Major concernsMajor concernsMajor concernsNo concernsREI:SP0Some concernsMajor concernsSome concernsNo concernsREI:ST0Major concernsMajor concernsSome concernsNo concernsREI:STL0Some concernsMajor concernsMajor concernsNo concernsREI:SU0Some concernsMajor concernsNo concernsNo concernsREI:SUL0Some concernsMajor concernsSome concernsNo concernsREI:TH0No concernsMajor concernsNo concernsNo concernsREL:REP0Some concernsMajor concernsMajor concernsNo concernsREL:RET0Major concernsMajor concernsMajor concernsNo concernsREL:SP0Some concernsMajor concernsMajor concernsNo concernsREL:ST0No concernsSome concernsMajor concernsNo concernsREL:STL0Some concernsSome concernsMajor concernsNo concernsREL:SU0No concernsSome concernsMajor concernsNo concernsREL:SUL0Some concernsMajor concernsMajor concernsNo concernsREL:TH0No concernsSome concernsMajor concernsNo concernsREP:RET0Some concernsMajor concernsMajor concernsNo concernsREP:SP0Some concernsMajor concernsMajor concernsNo concernsREP:ST0Some concernsMajor concernsMajor concernsNo concernsREP:STL0Some concernsMajor concernsMajor concernsNo concernsREP:SU0Some concernsMajor concernsMajor concernsNo concernsREP:SUL0Some concernsMajor concernsMajor concernsNo concernsREP:TH0Some concernsMajor concernsMajor concernsNo concernsRET:SP0Some concernsMajor concernsMajor concernsNo concernsRET:ST0Major concernsMajor concernsMajor concernsNo concernsRET:STL0Major concernsMajor concernsMajor concernsNo concernsRET:SU0Major concernsMajor concernsSome concernsNo concernsRET:SUL0Major concernsMajor concernsMajor concernsNo concernsRET:TH0Major concernsMajor concernsSome concernsNo concernsSP:ST0Some concernsMajor concernsMajor concernsNo concernsSP:STL0Some concernsMajor concernsMajor concernsNo concernsSP:SU0Some concernsMajor concernsMajor concernsNo concernsSP:SUL0Some concernsMajor concernsMajor concernsNo concernsSP:TH0Some concernsMajor concernsMajor concernsNo concernsST:SU0Some concernsMajor concernsSome concernsNo concernsST:SUL0Some concernsMajor concernsMajor concernsNo concernsST:TH0No concernsSome concernsSome concernsNo concernsSTL:SU0Some concernsNo concernsMajor concernsNo concernsSTL:SUL0Some concernsMajor concernsMajor concernsNo concernsSTL:TH0No concernsSome concernsMajor concernsNo concernsSU:SUL0Some concernsMajor concernsMajor concernsNo concernsSU:TH0No concernsSome concernsMajor concernsNo concernsSUL:TH0Some concernsMajor concernsMajor concernsNo concernsSupplementary table 13: Grade summary of evidence for non-specific lung lesions as an outcome in a network meta-analysis of bacterial vaccines to prevent respiratory disease in swine. The comparisons shown represent comparisons between eligible vaccines; comparisons where the number of contributing studies is equal to zero represent indirect evidence. Comparison# of studiesRandomizationBlindingImprecisionHeterogeneityHR:NAC1Some concernsMajor concernsMajor concernsNo concernsHY:ST1Major concernsNo concernsMajor concernsNo concernsIAC:NAC1Some concernsMajor concernsMajor concernsNo concernsIAC:PC1Some concernsMajor concernsNo concernsSome concernsIM:RE2Major concernsMajor concernsNo concernsSome concernsMY:NAC1Some concernsMajor concernsNo concernsSome concernsMYC:NAC1Some concernsMajor concernsSome concernsSome concernsMYC:PC1Some concernsMajor concernsMajor concernsNo concernsMYC:REP1Some concernsMajor concernsMajor concernsNo concernsNAC:PAP2Some concernsMajor concernsNo concernsSome concernsNAC:PC2Some concernsMajor concernsNo concernsSome concernsNAC:PO2Some concernsSome concernsNo concernsNo concernsNAC:RE2Major concernsMajor concernsNo concernsNo concernsNAC:REI1Major concernsMajor concernsNo concernsNo concernsNAC:RET2Major concernsMajor concernsNo concernsNo concernsNAC:ST6Major concernsSome concernsNo concernsNo concernsNAC:STL1Some concernsNo concernsMajor concernsNo concernsNAC:SU2Some concernsNo concernsNo concernsNo concernsNAC:VM1Major concernsMajor concernsNo concernsSome concernsPO:ST1Some concernsMajor concernsMajor concernsNo concernsRE:REI1Major concernsMajor concernsMajor concernsNo concernsRE:SP1Some concernsMajor concernsMajor concernsNo concernsST:STL1Some concernsNo concernsNo concernsSome concernsHR:HY0Major concernsSome concernsMajor concernsNo concernsHR:IAC0Some concernsMajor concernsMajor concernsNo concernsHR:IM0Major concernsMajor concernsMajor concernsNo concernsHR:MY0Some concernsMajor concernsMajor concernsNo concernsHR:MYC0Some concernsMajor concernsMajor concernsNo concernsHR:PAP0Some concernsMajor concernsMajor concernsNo concernsHR:PC0Some concernsMajor concernsMajor concernsNo concernsHR:PO0Some concernsMajor concernsMajor concernsNo concernsHR:RE0Major concernsMajor concernsMajor concernsNo concernsHR:REI0Major concernsMajor concernsMajor concernsNo concernsHR:REP0Some concernsMajor concernsMajor concernsNo concernsHR:RET0Major concernsMajor concernsNo concernsSome concernsHR:SP0Some concernsMajor concernsMajor concernsNo concernsHR:ST0Some concernsMajor concernsMajor concernsNo concernsHR:STL0Some concernsSome concernsMajor concernsNo concernsHR:SU0Some concernsSome concernsMajor concernsNo concernsHR:VM0Major concernsMajor concernsMajor concernsNo concernsHY:IAC0Some concernsSome concernsNo concernsNo concernsHY:IM0Major concernsSome concernsMajor concernsNo concernsHY:MY0Major concernsSome concernsMajor concernsNo concernsHY:MYC0Some concernsSome concernsMajor concernsNo concernsHY:NAC0Major concernsSome concernsNo concernsNo concernsHY:PAP0Major concernsSome concernsSome concernsSome concernsHY:PC0Some concernsSome concernsMajor concernsNo concernsHY:PO0Major concernsSome concernsMajor concernsNo concernsHY:RE0Major concernsSome concernsMajor concernsNo concernsHY:REI0Major concernsSome concernsMajor concernsNo concernsHY:REP0Some concernsSome concernsMajor concernsNo concernsHY:RET0Major concernsSome concernsNo concernsNo concernsHY:SP0Major concernsSome concernsMajor concernsNo concernsHY:STL0Some concernsNo concernsNo concernsNo concernsHY:SU0Major concernsSome concernsMajor concernsNo concernsHY:VM0Major concernsSome concernsMajor concernsNo concernsIAC:IM0Major concernsMajor concernsNo concernsNo concernsIAC:MY0Some concernsMajor concernsSome concernsSome concernsIAC:MYC0Some concernsMajor concernsMajor concernsNo concernsIAC:PAP0Some concernsMajor concernsMajor concernsNo concernsIAC:PO0Some concernsMajor concernsNo concernsSome concernsIAC:RE0Some concernsMajor concernsNo concernsNo concernsIAC:REI0Major concernsMajor concernsNo concernsNo concernsIAC:REP0Some concernsMajor concernsMajor concernsNo concernsIAC:RET0Some concernsMajor concernsNo concernsNo concernsIAC:SP0Some concernsMajor concernsSome concernsSome concernsIAC:ST0Some concernsMajor concernsNo concernsSome concernsIAC:STL0Some concernsSome concernsMajor concernsNo concernsIAC:SU0Some concernsSome concernsSome concernsSome concernsIAC:VM0Some concernsMajor concernsSome concernsSome concernsIM:MY0Major concernsMajor concernsSome concernsSome concernsIM:MYC0Major concernsMajor concernsNo concernsNo concernsIM:NAC0Major concernsMajor concernsNo concernsNo concernsIM:PAP0Major concernsMajor concernsNo concernsNo concernsIM:PC0Major concernsMajor concernsNo concernsNo concernsIM:PO0Major concernsMajor concernsNo concernsNo concernsIM:REI0Major concernsMajor concernsMajor concernsNo concernsIM:REP0Some concernsMajor concernsNo concernsSome concernsIM:RET0Major concernsMajor concernsMajor concernsNo concernsIM:SP0Major concernsMajor concernsSome concernsSome concernsIM:ST0Major concernsMajor concernsNo concernsNo concernsIM:STL0Major concernsSome concernsNo concernsNo concernsIM:SU0Major concernsMajor concernsNo concernsNo concernsIM:VM0Major concernsMajor concernsNo concernsNo concernsMY:MYC0Some concernsMajor concernsMajor concernsNo concernsMY:PAP0Some concernsMajor concernsMajor concernsNo concernsMY:PC0Some concernsMajor concernsMajor concernsNo concernsMY:PO0Some concernsMajor concernsMajor concernsNo concernsMY:RE0Major concernsMajor concernsMajor concernsNo concernsMY:REI0Major concernsMajor concernsMajor concernsNo concernsMY:REP0Some concernsMajor concernsMajor concernsNo concernsMY:RET0Major concernsMajor concernsNo concernsNo concernsMY:SP0Some concernsMajor concernsMajor concernsNo concernsMY:ST0Some concernsMajor concernsMajor concernsNo concernsMY:STL0Some concernsSome concernsMajor concernsNo concernsMY:SU0Some concernsSome concernsMajor concernsNo concernsMY:VM0Major concernsMajor concernsMajor concernsNo concernsMYC:PAP0Some concernsMajor concernsMajor concernsNo concernsMYC:PO0Some concernsMajor concernsMajor concernsNo concernsMYC:RE0Some concernsMajor concernsMajor concernsNo concernsMYC:REI0Major concernsMajor concernsMajor concernsNo concernsMYC:RET0Major concernsMajor concernsNo concernsNo concernsMYC:SP0Some concernsMajor concernsMajor concernsNo concernsMYC:ST0Some concernsMajor concernsMajor concernsNo concernsMYC:STL0Some concernsSome concernsMajor concernsNo concernsMYC:SU0Some concernsSome concernsMajor concernsNo concernsMYC:VM0Some concernsMajor concernsMajor concernsNo concernsNAC:REP0Some concernsMajor concernsMajor concernsNo concernsNAC:SP0Major concernsMajor concernsNo concernsSome concernsPAP:PC0Some concernsMajor concernsMajor concernsNo concernsPAP:PO0Some concernsSome concernsMajor concernsNo concernsPAP:RE0Major concernsMajor concernsNo concernsMajor concernsPAP:REI0Major concernsMajor concernsSome concernsSome concernsPAP:REP0Some concernsMajor concernsMajor concernsNo concernsPAP:RET0Major concernsMajor concernsNo concernsNo concernsPAP:SP0Some concernsMajor concernsMajor concernsNo concernsPAP:ST0Some concernsSome concernsSome concernsSome concernsPAP:STL0Some concernsSome concernsMajor concernsNo concernsPAP:SU0Some concernsSome concernsMajor concernsNo concernsPAP:VM0Major concernsMajor concernsMajor concernsNo concernsPC:PO0Some concernsMajor concernsMajor concernsNo concernsPC:RE0Some concernsMajor concernsMajor concernsNo concernsPC:REI0Major concernsMajor concernsMajor concernsNo concernsPC:REP0Some concernsMajor concernsMajor concernsNo concernsPC:RET0Major concernsMajor concernsNo concernsNo concernsPC:SP0Some concernsMajor concernsMajor concernsNo concernsPC:ST0Some concernsMajor concernsMajor concernsNo concernsPC:STL0Some concernsSome concernsMajor concernsNo concernsPC:SU0Some concernsSome concernsMajor concernsNo concernsPC:VM0Some concernsMajor concernsMajor concernsNo concernsPO:RE0Major concernsMajor concernsMajor concernsNo concernsPO:REI0Major concernsMajor concernsMajor concernsNo concernsPO:REP0Some concernsMajor concernsMajor concernsNo concernsPO:RET0Major concernsMajor concernsNo concernsNo concernsPO:SP0Some concernsMajor concernsMajor concernsNo concernsPO:STL0Some concernsSome concernsSome concernsSome concernsPO:SU0Some concernsSome concernsMajor concernsNo concernsPO:VM0Major concernsMajor concernsMajor concernsNo concernsRE:REP0Some concernsMajor concernsMajor concernsNo concernsRE:RET0Major concernsMajor concernsNo concernsNo concernsRE:ST0Major concernsMajor concernsMajor concernsNo concernsRE:STL0Major concernsSome concernsNo concernsNo concernsRE:SU0Major concernsSome concernsSome concernsSome concernsRE:VM0Major concernsMajor concernsMajor concernsNo concernsREI:REP0Some concernsMajor concernsMajor concernsNo concernsREI:RET0Major concernsMajor concernsNo concernsSome concernsREI:SP0Major concernsMajor concernsMajor concernsNo concernsREI:ST0Major concernsMajor concernsMajor concernsNo concernsREI:STL0Major concernsSome concernsNo concernsNo concernsREI:SU0Major concernsSome concernsMajor concernsNo concernsREI:VM0Major concernsMajor concernsMajor concernsNo concernsREP:RET0Some concernsMajor concernsNo concernsNo concernsREP:SP0Some concernsMajor concernsMajor concernsNo concernsREP:ST0Some concernsMajor concernsMajor concernsNo concernsREP:STL0Some concernsSome concernsMajor concernsNo concernsREP:SU0Some concernsMajor concernsMajor concernsNo concernsREP:VM0Some concernsMajor concernsMajor concernsNo concernsRET:SP0Major concernsMajor concernsNo concernsNo concernsRET:ST0Major concernsMajor concernsNo concernsNo concernsRET:STL0Major concernsSome concernsNo concernsNo concernsRET:SU0Major concernsSome concernsNo concernsNo concernsRET:VM0Major concernsMajor concernsNo concernsNo concernsSP:ST0Major concernsMajor concernsMajor concernsNo concernsSP:STL0Some concernsSome concernsMajor concernsNo concernsSP:SU0Some concernsMajor concernsMajor concernsNo concernsSP:VM0Major concernsMajor concernsMajor concernsNo concernsST:SU0Some concernsSome concernsMajor concernsNo concernsST:VM0Major concernsMajor concernsMajor concernsNo concernsSTL:SU0Some concernsNo concernsMajor concernsNo concernsSTL:VM0Some concernsSome concernsMajor concernsNo concernsSU:VM0Major concernsSome concernsMajor concernsNo concernsFiguresSupplementary Figure 1. Summary of individual trial risk of bias assessment for trials measuring morbidity as an outcome, and included in a network meta-analysis on the efficacy of bacterial vaccines for respiratory disease in swine.Supplementary Figure 2. Summary of individual trial risk of bias assessment for trials measuring mortality as an outcome, and included in a network meta-analysis on the efficacy of bacterial vaccines for respiratory disease in swine.Supplementary Figure 3. Summary of individual trial risk of bias assessment for trials measuring the presence / absence of non-specific lung lesions at slaughter as an outcome, and included in a network meta-analysis on the efficacy of bacterial vaccines for respiratory disease in swine.Supplementary Figure 4: The distribution of the probability of failure (morbidity) for each eligible vaccine from a network meta-analysis of bacterial vaccines to prevent respiratory disease in swine.Supplementary Figure 5: The distribution of the probability of failure (mortality) for each eligible vaccine from a network meta-analysis of bacterial vaccines to prevent respiratory disease in swine.Supplementary Figure 6: The distribution of the probability of failure (presence of non-specific lung lesions) for each eligible vaccine from a network meta-analysis of bacterial vaccines to prevent respiratory disease in swine.Supplementary Figure 7: The contribution of trials to the risk ratio estimates for morbidity as an outcome based on the approach to randomization; green indicates that allocation to intervention group was random and that the method of generating the random sequence was provided, yellow indicates that the authors stated that allocation was random but did not describe the method of generating the random allocation sequence, and red indicates that allocation to intervention group was not random or was not reported. White vertical lines indicate the percentage contribution of separate studies.Supplementary Figure 8: The contribution of trials to the risk ratio estimates for mortality as an outcome based on the approach to randomization; green indicates that allocation to intervention group was random and that the method of generating the random sequence was provided, yellow indicates that the authors stated that allocation was random but did not describe the method of generating the random allocation sequence, and red indicates that allocation to intervention group was not random or was not reported. White vertical lines indicate the percentage contribution of separate studies.Supplementary Figure 9: The contribution of trials to the risk ratio estimates for non-specific lung lesions as an outcome based on the approach to randomization; green indicates that allocation to intervention group was random and that the method of generating the random sequence was provided, yellow indicates that the authors stated that allocation was random but did not describe the method of generating the random allocation sequence, and red indicates that allocation to intervention group was not random or was not reported. White vertical lines indicate the percentage contribution of separate studies.Supplementary Figure 10: The contribution of trials to the risk ratio estimates for morbidity as an outcome based on the approach to blinding: green indicates that both outcome assessors and care-givers were blinded to intervention status, yellow indicates that one, but not both, of outcome assessors and care-givers was blinded, and red indicates that neither was blinded or that blinding was not reported. White vertical lines indicate the percentage contribution of separate studies.Supplementary Figure 11: The contribution of trials to the risk ratio estimates for mortality as an outcome based on the approach to blinding: green indicates that both outcome assessors and care-givers were blinded to intervention status, yellow indicates that one, but not both, of outcome assessors and care-givers was blinded, and red indicates that neither was blinded or that blinding was not reported. White vertical lines indicate the percentage contribution of separate studies. Supplementary Figure 12: The contribution of trials to the risk ratio estimates for non-specific lung lesions as an outcome based on the approach to blinding: green indicates that both outcome assessors and care-givers were blinded to intervention status, yellow indicates that one, but not both, of outcome assessors and care-givers was blinded, and red indicates that neither was blinded or that blinding was not reported. White vertical lines indicate the percentage contribution of separate studies. ................
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