The Central Alabama Veteran Health Care System …
– Fungistatic. Inhibit ergosterol/steroid synthesis (blocks cytochrome p450), ↑ cell membrane permeability, ↓ cell membrane fluidity. Use for dermatophytes, yeast, dimorphic fungi. Impairs steroid sythesis, so sometimes used in hyperadrenocorticism and prostate diz. Ketaconazole – Fairly safe (hepatotoxicity), give w/ food. Short t½. ................
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