University of Edinburgh
Cerebral blood flow in small vessel disease: a systematic review and meta-analysisShort title. Cerebral blood flow in small vessel diseaseYulu Shi, MBBS, MNeurol; Michael J Thrippleton, PhD; Stephen D Makin, MB ChB; Ian Marshall, PhD; Mirjam I Geerlings, PhD; ?Anton J. M. de Craen, PhD; Mark A van Buchem, MD, PhD; Joanna M Wardlaw, MDAffiliations and address:Centre for Clinical Brain Sciences (Y.S., M.J.T., I.M., S.D.M., J.M.W), University of Edinburgh, Edinburgh, United Kingdom; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (S.D.M); University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, Utrecht, The Netherlands (M.I.G); Department of Gerontology and Geriatrics (A.J.M.D.C.), Department of Radiology (M.A.V.B.), Leiden University Medical Centre, Leiden, Netherlands, and Department of Neurology, Zhongnan Hospital, Wuhan University, Wuhan, China (Y.S.). ? Deceased.Dedication: This paper is dedicated to the memory of Dr Anton J M de Craen who is sorely missedCorrespondence to: Prof Joanna M Wardlaw, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, EH16 4SB, United Kingdom. Joanna.Wardlaw@ed.ac.uk. Phone: +44-(0)131-465-9588Word counts: 4094 words Tabs: 3Figs: 4Key words: Cerebral Blood flow; Cerebral Small Vessel Disease; White Matter Hyperintensities; Systematic Review; Meta-analysisAbstractWhite matter hyperintensities (WMHs) are frequent on neuroimaging of older people and are a key feature of cerebral small vessel disease (SVD). They are commonly attributed to chronic hypoperfusion, although whether low cerebral blood flow (CBF) is cause or effect is unclear. We systematically reviewed studies that assessed CBF in SVD patients, performed meta-analysis and sensitivity analysis of potential confounders. 38 studies (n=4006) met the inclusion criteria, including four longitudinal and 34 cross-sectional studies. Most CBF data were from grey matter. 24 cross-sectional studies (n=1161) were meta-analysed, showing that CBF was lower in subjects with more WMH, globally and in most grey and white matter regions (e.g. mean global CBF: standardised mean difference -0.71, 95% CI -1.12, -0.30). These CBF differences were attenuated by excluding studies in dementia or that lacked age-matching. Four longitudinal studies (n=1079) gave differing results, e.g.: more baseline WMH predated falling CBF (3.9y, n=575); CBF was low in regions that developed WMH (1.5y, n=40). CBF is lower in subjects with more WMH cross-sectionally, but evidence for falling CBF predating increasing WMH is conflicting. Future studies should be longitudinal, obtain more white matter data, use better age-correction and stratify by clinical diagnosis.IntroductionWhite matter hyperintensities (WMHs) are commonly seen on brain magnetic resonance imaging (MRI) in older people and are considered as one of the core neuroimaging findings of cerebral small vessel disease (SVD). They are defined as patchy or confluent hyperintensities on T2-weighted or FLAIR images, without cavitation, in subcortical white or deep grey matter regions.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5XYXJkbGF3PC9BdXRob3I+PFllYXI+MjAxMzwvWWVhcj48
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ADDIN EN.CITE.DATA 1 WMHs are associated with increasing age and vascular risk factors such as hypertension and diabetes. ADDIN EN.CITE <EndNote><Cite><Author>Jeerakathil</Author><Year>2004</Year><RecNum>5232</RecNum><DisplayText><style face="superscript">2</style></DisplayText><record><rec-number>5232</rec-number><foreign-keys><key app="EN" db-id="zpdv0e098attenedfv1pfefqpxar9e5a20ez" timestamp="1445994662">5232</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Jeerakathil, T.</author><author>Wolf, P. A.</author><author>Beiser, A.</author><author>Massaro, J.</author><author>Seshadri, S.</author><author>D'Agostino, R. B.</author><author>DeCarli, C.</author></authors></contributors><auth-address>Division of Neurology, Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.</auth-address><titles><title>Stroke risk profile predicts white matter hyperintensity volume: the Framingham Study</title><secondary-title>Stroke</secondary-title></titles><periodical><full-title>Stroke</full-title><abbr-1>Stroke; a journal of cerebral circulation</abbr-1></periodical><pages>1857-61</pages><volume>35</volume><number>8</number><keywords><keyword>Adult</keyword><keyword>Aged</keyword><keyword>Aged, 80 and over</keyword><keyword>Brain/*pathology</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Leukoaraiosis/*pathology</keyword><keyword>*Magnetic Resonance Imaging</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Risk Factors</keyword><keyword>Stroke/*epidemiology</keyword></keywords><dates><year>2004</year><pub-dates><date>Aug</date></pub-dates></dates><isbn>1524-4628 (Electronic)
0039-2499 (Linking)</isbn><accession-num>15218158</accession-num><urls><related-urls><url> Although the aetiology is not completely understood, chronic hypoperfusion is thought to be a key mechanism, ADDIN EN.CITE <EndNote><Cite><Author>Yata</Author><Year>2014</Year><RecNum>2694</RecNum><DisplayText><style face="superscript">3</style></DisplayText><record><rec-number>2694</rec-number><foreign-keys><key app="EN" db-id="zpdv0e098attenedfv1pfefqpxar9e5a20ez" timestamp="1422376169">2694</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Yata, K.</author><author>Tomimoto, H.</author></authors></contributors><auth-address>(Yata, Tomimoto) Department of Neurology, Mie University Graduate School of Medicine, Tsu, Japan</auth-address><titles><title>Chronic cerebral hypoperfusion and dementia</title><secondary-title>Neurol Clin Neurosci</secondary-title></titles><periodical><full-title>Neurol Clin Neurosci</full-title></periodical><pages>129-134</pages><volume>2</volume><number>5</number><dates><year>2014</year><pub-dates><date>01 Sep</date></pub-dates></dates><accession-num>2014830962</accession-num><work-type>Review</work-type><urls><related-urls><url> Technologies</remote-database-provider></record></Cite></EndNote>3 perhaps resulting from narrowing of the arteriolar lumena secondary to lipohyalinosis and arteriolosclerosis. Based on this theory, mechanically-induced hypoperfusion models, for example partial or complete carotid artery occlusion, are used to create pathology that appears to mimic human SVD. However, no direct association between carotid artery stenosis and lacunar stroke or WMH has been found in human studies.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Qb3R0ZXI8L0F1dGhvcj48WWVhcj4yMDEyPC9ZZWFyPjxS
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ADDIN EN.CITE.DATA 4Additionally, the relationship between CBF and WMH is not consistent across human studies. In some cross-sectional studies, low CBF was significantly related to more WMHs, whereas in other studies, no such relationship was found.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5JYmF5YXNoaTwvQXV0aG9yPjxZZWFyPjIwMDA8L1llYXI+
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ADDIN EN.CITE.DATA 5,6 These studies had different study designs, sample sizes and locations where low CBF was detected and most were cross-sectional. There are few longitudinal studies. Thus it is unclear whether there is causal relationship between low CBF and WMHs in humans, or whether there is region specificity. We sought to establish if WMH were related to changes in CBF levels, or whether differences in CBF might be related to potential confounders such as age and tissue loss. We systematically reviewed the available longitudinal and cross-sectional studies in humans, performed a meta-analysis of cross-sectional studies to assess the overall effect size of CBF differences by WMH burden in different brain regions, assessed study quality and performed sensitivity analyses on important confounders. MethodsWe performed this review according to guidelines ADDIN EN.CITE <EndNote><Cite><Author>Stroup</Author><Year>2000</Year><RecNum>5326</RecNum><DisplayText><style face="superscript">7</style></DisplayText><record><rec-number>5326</rec-number><foreign-keys><key app="EN" db-id="zpdv0e098attenedfv1pfefqpxar9e5a20ez" timestamp="1457991009">5326</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Stroup, D. F.</author><author>Berlin, J. A.</author><author>Morton, S. C.</author><author>Olkin, I.</author><author>Williamson, G. D.</author><author>Rennie, D.</author><author>Moher, D.</author><author>Becker, B. J.</author><author>Sipe, T. A.</author><author>Thacker, S. B.</author></authors></contributors><auth-address>Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. dfs2@</auth-address><titles><title>Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group</title><secondary-title>JAMA</secondary-title></titles><periodical><full-title>JAMA</full-title></periodical><pages>2008-12</pages><volume>283</volume><number>15</number><keywords><keyword>Epidemiology</keyword><keyword>*Meta-Analysis as Topic</keyword><keyword>Observation</keyword></keywords><dates><year>2000</year><pub-dates><date>Apr 19</date></pub-dates></dates><isbn>0098-7484 (Print)
0098-7484 (Linking)</isbn><accession-num>10789670</accession-num><urls><related-urls><url> and a pre-specified protocol. We conducted a literature search of MEDLINE and EMBASE from 1946 up to December 2015, using the Ovid Web Gateway. We used exploded headings related to Small Vessel Disease and Cerebral Blood Flow with the Boolean operator AND [Supplementary methods]. English and non-English literature were sought. Additional records were identified by hand searching from January 1990-December 2015 of Stroke and Journal of Cerebral Blood Flow & Metabolism. We also checked references cited in reviews and primary papers. Eligibility criteria We sought longitudinal and cross-sectional primary research studies assessing CBF in subjects with cerebral SVD.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5XYXJkbGF3PC9BdXRob3I+PFllYXI+MjAxMzwvWWVhcj48
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ADDIN EN.CITE.DATA 8 Studies measuring cerebral blood flow velocity (CBFv) using Doppler ultrasound techniques were also considered eligible. We excluded studies targeting at unilateral or bilateral severe carotid stenosis or occlusion, studies in children, animal studies, duplicate publications, conference abstracts, and cross-sectional studies from which we could not extract either absolute values of CBF or correlation/regression coefficients. Data extraction and analysisWe screened all potentially relevant full papers and extracted data using a standardised form. All data were cross-checked by a second reviewer (JMW). From those that met the inclusion criteria, we extracted data on study population characteristics, study design, SVD and CBF measurement techniques and units. We assessed the study quality using a checklist devised on the basis of the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement (equator-) and checklist in a previous paper ADDIN EN.CITE <EndNote><Cite><Author>Bailey</Author><Year>2012</Year><RecNum>5321</RecNum><DisplayText><style face="superscript">9</style></DisplayText><record><rec-number>5321</rec-number><foreign-keys><key app="EN" db-id="zpdv0e098attenedfv1pfefqpxar9e5a20ez" timestamp="1452249676">5321</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Bailey, E. L.</author><author>Smith, C.</author><author>Sudlow, C. L.</author><author>Wardlaw, J. M.</author></authors></contributors><auth-address>Division of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Edinburgh, UK.</auth-address><titles><title>Pathology of lacunar ischemic stroke in humans--a systematic review</title><secondary-title>Brain Pathol</secondary-title></titles><periodical><full-title>Brain Pathol</full-title></periodical><pages>583-91</pages><volume>22</volume><number>5</number><keywords><keyword>Brain Ischemia/*complications</keyword><keyword>Databases, Factual/statistics & numerical data</keyword><keyword>Humans</keyword><keyword>Stroke, Lacunar/*etiology/*pathology</keyword><keyword>Terminology as Topic</keyword></keywords><dates><year>2012</year><pub-dates><date>Sep</date></pub-dates></dates><isbn>1750-3639 (Electronic)
1015-6305 (Linking)</isbn><accession-num>22329603</accession-num><urls><related-urls><url>, including factors such as study population and bias controlling (Supplementary table S1). For cross-sectional studies which reported means and standard deviations (S.D.s) of CBF, we extracted data on CBF in disease and control groups or according to SVD burden. Means and S.D.s were extracted from text or tables where available, or from graphs where necessary. For cross-sectional studies where only qualitative data for association between CBF and WMH were available, we included the studies in the review but not in the meta-analysis: we noted the statistical methods, coefficients, P values and other covariates included in regression. For longitudinal studies, we also listed follow-up durations and primary results extracted from the papers, and contacted the authors to request unpublished data on baseline and follow-up CBF and WMH volume. Data transformation and analysisAll studies reporting means and S.D.s were included for meta-analysis. For studies that divided patients into more than two grades of WMH severity, we combined the means and S.D.s of groups to create a single pair-wise comparison [Supplementary methods]. As most studies measured CBF in several regions of interest (ROIs), such as different grey matter and white matter regions, we conducted subgroup analysis by brain region. Due to various units of CBF being used in different papers, we calculated the standardized mean differences (SMD) and 95% confidence intervals (CI) for comparisons using a random-effects model. Sensitivity analyses were carried out for subjects with/without dementia and by age matching between study groups, as both strongly influence CBF. Meta-analyses were conducted using the Cochrane Collaboration’s Review Manager (Revman Version 5.3). We assessed for heterogeneity by calculating the I2 statistic and publication bias using a funnel plot. ResultsA total of 2843 publications were initially identified, of which 75 were potentially eligible and were selected for further review. We ultimately included 38 articles and excluded (Figure 1): conference abstracts (6), those where we were unable to access the full text (6) or that had no analysable data (18), duplicate publications including the same participant population (3), and studies of severe carotid stenosis or occlusion (4). Note that although presence of arterial diseases was an inclusion criteria of Second Manifestations of ARTerial disease-magnetic resonance (SMART-MR) study, carotid arterial stenosis or occlusion was not one of the criteria: here patients with carotid artery stenosis were included, but they only represented a small proportion of participants, thus we included the study PEVuZE5vdGU+PENpdGU+PEF1dGhvcj52YW4gZGVyIFZlZW48L0F1dGhvcj48WWVhcj4yMDE1PC9Z
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ADDIN EN.CITE.DATA 10 in our review. The 38 studies included a total of 4006 participants: 4/38 were longitudinal and 34/38 were cross-sectional. Some papers are from the same studies: van der Veen et al.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj52YW4gZGVyIFZlZW48L0F1dGhvcj48WWVhcj4yMDE1PC9Z
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ADDIN EN.CITE.DATA 10 and Bisschops et al.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CaXNzY2hvcHM8L0F1dGhvcj48WWVhcj4yMDA0PC9ZZWFy
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ADDIN EN.CITE.DATA 5 AD diagnosis used the criteria of the National Institute of Neurological and Communicative Disorders and Stroke, and the Alzheimer’s disease and Related Disorders Association (NINCDS/ADRDA) for probable AD. Vascular dementia diagnosis varied: CT/MRI evidence, DSM-III-R criteria,PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Lb2Jhcmk8L0F1dGhvcj48WWVhcj4xOTkwPC9ZZWFyPjxS
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ADDIN EN.CITE.DATA 21-31 one study performed the comparison between patients with depression (DSM-IV criteria) plus WMHs vs no WMHs, ADDIN EN.CITE <EndNote><Cite><Author>Kimura</Author><Year>2003</Year><RecNum>2610</RecNum><DisplayText><style face="superscript">32</style></DisplayText><record><rec-number>2610</rec-number><foreign-keys><key app="EN" db-id="zpdv0e098attenedfv1pfefqpxar9e5a20ez" timestamp="1422376167">2610</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Kimura, M.</author><author>Shimoda, K.</author><author>Mizumura, S.</author><author>Tateno, A.</author><author>Fujito, T.</author><author>Mori, T.</author><author>Endo, S.</author></authors></contributors><auth-address>Kimura,Mahito. Department of Neuropsychiatry, Nippon Medical School, Tokyo, Japan. mkimura@med.email.ne.jp</auth-address><titles><title>Regional cerebral blood flow in vascular depression assessed by 123I-IMP SPECT</title><secondary-title>J Nippon Med Sch</secondary-title></titles><periodical><full-title>J Nippon Med Sch</full-title></periodical><pages>321-6</pages><volume>70</volume><number>4</number><dates><year>2003</year></dates><accession-num>12928712</accession-num><urls><related-urls><url> Technologies</remote-database-provider></record></Cite></EndNote>32 and the other four papers examined the differences in CBF across grades of WMH severity.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5GdTwvQXV0aG9yPjxZZWFyPjIwMTQ8L1llYXI+PFJlY051
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ADDIN EN.CITE.DATA 33,34 Two studies recruited patients with acute ischemic symptoms: in Nezu et al.,PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5OZXp1PC9BdXRob3I+PFllYXI+MjAxMjwvWWVhcj48UmVj
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ADDIN EN.CITE.DATA 21 patients presented with minor ischemic stroke and brain scans were performed at least three weeks after onset; Huynh et al. only included TIA patients and brain scans were done acutely. ADDIN EN.CITE <EndNote><Cite><Author>Huynh</Author><Year>2008</Year><RecNum>5227</RecNum><DisplayText><style face="superscript">36</style></DisplayText><record><rec-number>5227</rec-number><foreign-keys><key app="EN" db-id="zpdv0e098attenedfv1pfefqpxar9e5a20ez" timestamp="1445355617">5227</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Huynh, T. J.</author><author>Murphy, B.</author><author>Pettersen, J. A.</author><author>Tu, H.</author><author>Sahlas, D. J.</author><author>Zhang, L.</author><author>Symons, S. P.</author><author>Black, S.</author><author>Lee, T. Y.</author><author>Aviv, R. I.</author></authors></contributors><auth-address>Department of Medicine, University of Toronto, Toronto, Ontario, Canada.</auth-address><titles><title>CT perfusion quantification of small-vessel ischemic severity</title><secondary-title>AJNR Am J Neuroradiol</secondary-title></titles><periodical><full-title>AJNR Am J Neuroradiol</full-title></periodical><pages>1831-6</pages><volume>29</volume><number>10</number><keywords><keyword>Aged</keyword><keyword>Brain Ischemia/*radiography</keyword><keyword>Demyelinating Diseases/*radiography</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Male</keyword><keyword>Nerve Fibers, Myelinated/*radiography</keyword><keyword>Reproducibility of Results</keyword><keyword>Sensitivity and Specificity</keyword><keyword>Severity of Illness Index</keyword><keyword>Tomography, X-Ray Computed/*methods</keyword></keywords><dates><year>2008</year><pub-dates><date>Nov</date></pub-dates></dates><isbn>1936-959X (Electronic)
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ADDIN EN.CITE.DATA 41 and manifest arterial diseases. ADDIN EN.CITE <EndNote><Cite><Author>Bisschops</Author><Year>2004</Year><RecNum>2598</RecNum><DisplayText><style face="superscript">42</style></DisplayText><record><rec-number>2598</rec-number><foreign-keys><key app="EN" db-id="zpdv0e098attenedfv1pfefqpxar9e5a20ez" timestamp="1422618047">2598</key><key app="ENWeb" db-id="">0</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Bisschops, R. H.</author><author>van der Graaf, Y.</author><author>Mali, W. P.</author><author>van der Grond, J.</author><author>Smart study group</author></authors></contributors><auth-address>Bisschops,R H C. Department of Radiology E01.132, University Medical Center Utrecht, PO Box 85500, 3508, GA Utrecht, The Netherlands.</auth-address><titles><title>High total cerebral blood flow is associated with a decrease of white matter lesions</title><secondary-title>J Neurol</secondary-title></titles><periodical><full-title>J Neurol</full-title></periodical><pages>1481-5</pages><volume>251</volume><number>12</number><dates><year>2004</year></dates><accession-num>15645347</accession-num><urls><related-urls><url> Technologies</remote-database-provider></record></Cite></EndNote>42 Longitudinal studies Four longitudinal prospective studies, including 1079 participants, were included (insert Table 1). Three were hospital-basedPEVuZE5vdGU+PENpdGU+PEF1dGhvcj52YW4gZGVyIFZlZW48L0F1dGhvcj48WWVhcj4yMDE1PC9Z
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ADDIN EN.CITE.DATA 44 Among these four studies, Bernbaum et al. recruited participants who presented acute minor stroke symptoms or transient ischemic attack (TIA) and had baseline MRI within 48hrs after the onset. ADDIN EN.CITE <EndNote><Cite><Author>Bernbaum</Author><Year>2015</Year><RecNum>5258</RecNum><DisplayText><style face="superscript">43</style></DisplayText><record><rec-number>5258</rec-number><foreign-keys><key app="EN" db-id="zpdv0e098attenedfv1pfefqpxar9e5a20ez" timestamp="1448285099">5258</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Bernbaum, M.</author><author>Menon, B. K.</author><author>Fick, G.</author><author>Smith, E. E.</author><author>Goyal, M.</author><author>Frayne, R.</author><author>Coutts, S. B.</author></authors></contributors><titles><title>Reduced blood flow in normal white matter predicts development of leukoaraiosis</title><secondary-title>J Cereb Blood Flow Metab</secondary-title></titles><periodical><full-title>J Cereb Blood Flow Metab</full-title></periodical><pages>1610-1615</pages><volume>35</volume><number>10</number><dates><year>2015</year><pub-dates><date>03 Oct</date></pub-dates></dates><accession-num>2015043331</accession-num><urls><related-urls><url> Technologies</remote-database-provider></record></Cite></EndNote>43 The other three studies did not include acute patients. The follow-up durations ranged from 1.5 to 7.7 years. Kraut et al. compared the patterns of long-term CBF change in patients with progressive WMHs to those with stable WMHs,PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LcmF1dDwvQXV0aG9yPjxZZWFyPjIwMDg8L1llYXI+PFJl
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ADDIN EN.CITE.DATA 10,12,43 Quality assessmentThe average study quality score was 6/9. Scores were mainly lost for not reporting the drop-outs (25/38), no adjustment or matching for risk factors (including age) (17/38), not reporting expertise of image observers (20/38) and not using blinding (25/38) (Supplementary figure S1). Assessment of CBF measurement methodsThree studies used phase-contrast MRI,PEVuZE5vdGU+PENpdGU+PEF1dGhvcj52YW4gZGVyIFZlZW48L0F1dGhvcj48WWVhcj4yMDE1PC9Z
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ADDIN EN.CITE.DATA 24,37,38,40 Meta-analysis of differences in CBF by WMH burdenMeta-analysis using SMD in CBF was only possible for 24 cross-sectional studies. 22 brain regions were extracted, but sufficient data were available from only 11 regions which were used by at least three studies and were selected for the primary meta-analysis. These included: global brain mean CBF, basal ganglia, cortical grey matter (total, frontal, temporal, parietal and occipital grey matter) and white matter (total, frontal and occipital white matter, centrum semiovale). Most data were available for frontal grey matter; few studies provided white matter data. Patients with more severe WMH had lower CBF than patients with mild WMH, globally and in most grey and white matter regions (e.g. mean global CBF: SMD -0.71, 95% CI -1.12, -0.30; total grey matter: SMD -0.50, 95% CI -0.97, -0.03; total white matter: SMD -1.16, 95% CI -1.08, -0.53; see Figure 2a and Figure 2b), except in basal ganglia (SMD -1.25, 95% CI -2.53, 0.30) and occipital white matter (SMD -0.45, 95% CI -0.96, 0.05) where the difference in CBF did not reach significance. No studies in the meta-analysis separated normal appearing white matter (NAWM) and WMH. However, there was heterogeneity between studies for most of these comparisons (insert Figure 2a and Figure 2b) that was not due to publication bias (Funnel plot, Supplementary figure S2). One study found that CBF in patients with lacunar lesions was lower than in those without, however the result was not adjusted for WMH volume and could not be meta-analysed. ADDIN EN.CITE <EndNote><Cite><Author>Kobayashi</Author><Year>1991</Year><RecNum>2679</RecNum><DisplayText><style face="superscript">30</style></DisplayText><record><rec-number>2679</rec-number><foreign-keys><key app="EN" db-id="zpdv0e098attenedfv1pfefqpxar9e5a20ez" timestamp="1422376168">2679</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Kobayashi, S.</author><author>Okada, K.</author><author>Yamashita, K.</author></authors></contributors><auth-address>Kobayashi,S. Third Department of Internal Medicine, Shimane Medical University, Japan.</auth-address><titles><title>Incidence of silent lacunar lesion in normal adults and its relation to cerebral blood flow and risk factors</title><secondary-title>Stroke</secondary-title></titles><periodical><full-title>Stroke</full-title><abbr-1>Stroke; a journal of cerebral circulation</abbr-1></periodical><pages>1379-83</pages><volume>22</volume><number>11</number><dates><year>1991</year></dates><accession-num>1750045</accession-num><urls><related-urls><url> Technologies</remote-database-provider></record></Cite></EndNote>30Sensitivity analysis of dementia and age We repeated the meta-analyses after excluding studies that included patients with dementia and then further excluded studies without age-matching. In most grey and white matter regions, the differences in CBF between subjects with high and low WMH burdens attenuated and were no longer significant, except for mean global brain CBF and centrum semiovale. Most of the trends in the comparisons were still the same, apart from temporal grey matter (insert Figure 3). Only one study, Ibayashi et al., used hypertensive but neurologically normal patients as the control group, and found lower CBF in patients with Binswanger’s dementia compared to the control group;PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5JYmF5YXNoaTwvQXV0aG9yPjxZZWFyPjIwMDA8L1llYXI+
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AA==
ADDIN EN.CITE.DATA 5 none of the other studies matched or adjusted for vascular risk factors. Therefore we were not able to do a sensitivity analysis for vascular risk factors. Hypertension is significantly more prevalent in patients with more severe WMH. Cross-sectional studies that provided data on associations between CBF and SVD featuresAmong the 10 cross-sectional papers which only performed association analysis, three studies did not find association between CBF and WMH burden.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DbGF1czwvQXV0aG9yPjxZZWFyPjE5OTY8L1llYXI+PFJl
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ADDIN EN.CITE.DATA 11,13,14,47 Negative correlation between WMH features and CBFv were found in three studies, of which one assessed CBFv in internal carotid arteries,PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5IZWxpb3BvdWxvczwvQXV0aG9yPjxZZWFyPjIwMTI8L1ll
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ADDIN EN.CITE.DATA 37,40 Amongst all 10 studies, six adjusted for covariates such as age, gender and other vascular risk factors (insert Table 2).PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5DcmFuZTwvQXV0aG9yPjxZZWFyPjIwMTU8L1llYXI+PFJl
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ADDIN EN.CITE.DATA 11,37,40,46-48 Longitudinal studiesIn longitudinal studies, the largest study (575 subjects), Van der Veen et al., found that high WMH volume at baseline was significantly associated with falling CBF over 3.9 years follow-up.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj52YW4gZGVyIFZlZW48L0F1dGhvcj48WWVhcj4yMDE1PC9Z
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ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj52YW4gZGVyIFZlZW48L0F1dGhvcj48WWVhcj4yMDE1PC9Z
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ADDIN EN.CITE.DATA 10 Ten dam et al. demonstrated in 390 subjects that a decline in global CBF over 2.75 years was associated with a progression in periventricular WMH (PVWMH) but not in deep WMH (DWMH).PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5UZW4gRGFtPC9BdXRob3I+PFllYXI+MjAwNzwvWWVhcj48
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ADDIN EN.CITE.DATA 12 A small study (n=40) found low CBF in regions that developed WMH over 1.5 years follow-up (baseline WMH volume 9.21±11.87 ml) (Table 3). ADDIN EN.CITE <EndNote><Cite><Author>Bernbaum</Author><Year>2015</Year><RecNum>5258</RecNum><DisplayText><style face="superscript">43</style></DisplayText><record><rec-number>5258</rec-number><foreign-keys><key app="EN" db-id="zpdv0e098attenedfv1pfefqpxar9e5a20ez" timestamp="1448285099">5258</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Bernbaum, M.</author><author>Menon, B. K.</author><author>Fick, G.</author><author>Smith, E. E.</author><author>Goyal, M.</author><author>Frayne, R.</author><author>Coutts, S. B.</author></authors></contributors><titles><title>Reduced blood flow in normal white matter predicts development of leukoaraiosis</title><secondary-title>J Cereb Blood Flow Metab</secondary-title></titles><periodical><full-title>J Cereb Blood Flow Metab</full-title></periodical><pages>1610-1615</pages><volume>35</volume><number>10</number><dates><year>2015</year><pub-dates><date>03 Oct</date></pub-dates></dates><accession-num>2015043331</accession-num><urls><related-urls><url> Technologies</remote-database-provider></record></Cite></EndNote>43 In contrast to the other findings of falling CBF over time, Kraut et al. demonstrated in 74 subjects that CBF increased in some brain areas (right inferior temporal gyrus, right anterior cingulate, and the left superior temporal gyrus) over 7.7 years in patients with progressive WMH.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LcmF1dDwvQXV0aG9yPjxZZWFyPjIwMDg8L1llYXI+PFJl
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ADDIN EN.CITE.DATA 44 Falling CBF was observed more in the posterior regions including right inferior parietal lobule and right occipital pole but was not specifically associated with WMH change. DiscussionWMHs are often considered to be a consequence of chronic hypoperfusion. However, while our review of all available published and some unpublished data show that high WMH load is associated with lower CBF, they do not strongly support causation. In cross-sectional studies, low CBF was observed in most of the patients with more WMHs. However the association was damped after removing non-age matched subjects and those with dementia, which suggests that the underlying association is between reduced CBF and age or dementia rather than just WMH. One longitudinal study (n=575) also showed a correlation between high baseline WMH volume and decrease in CBF over time, questioning whether a CBF decline causes the tissue loss or vice versa.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj52YW4gZGVyIFZlZW48L0F1dGhvcj48WWVhcj4yMDE1PC9Z
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ADDIN EN.CITE.DATA 10 The strengths of this systematic review include the use of well-established guidelines for meta-analysis, cautious exclusion of duplicate data, thorough analysis of different study types and sensitivity analysis of clinically-important subgroups. Some studies provided more than one comparison but we avoided double-counting the total number of participants. We used every piece of data we could obtain. Studies that recruited subjects with Alzheimer’s disease, heart failure and depression but compared CBF between patients with and without SVD were also included. Moreover, we included papers in non-English languages, including three papers in Chinese. As most studies measured regional CBF in different brain areas, we carefully chose regions that were mentioned by at least three studies to obtain robust SMDs in meta-analyses. There are some limitations of the review which in most part reflect the limitation of the literature. Firstly, there are differences between studies in terms of study design and imaging methods which we tried to harmonise to enable comparisons. Longitudinal studies were rare. Data for white matter regions such as centrum semiovale or immediate periventricular white matter were limited or lacking. CBF was obtained by different techniques and varied by technique. However, it is important to note that meta-analysis compares the magnitude of association within one study with that within the others, rather than making direct comparisons of CBF between studies. There are also differences in patient populations: most studies chose patients without neurological symptoms or from community-based populations, whereas three studies recruited patients with acute onset of TIA or minor stroke. Two studies used acute brain MRI as baseline imaging.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CZXJuYmF1bTwvQXV0aG9yPjxZZWFyPjIwMTU8L1llYXI+
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ADDIN EN.CITE.DATA 36,43 Image analysis methods differed and few if any studies differentiated normal tissue from WMH in the regions of interest, thus including more tissue affected by lesions in subjects with high WMH burdens than with few WMH – an obvious confound if measuring CBF. Secondly, as some studies divided subjects into different severity groups, we converted them into pair-wise comparisons in the form of low WMHs versus high WMHs. Therefore it is possible that disease groups in the original pair-wise studies might include some patients with mild lesions. Thirdly, the sample sizes of the studies included in meta-analyses were small – the whole analysis of 24 studies included 1161 patients (mean 48/study or 24/group). Only a few studies used age-matched controls. Patients with more severe WMHs were in general significantly older than those who had mild or no WMH, introducing an obvious confound; we addressed this in sensitivity analyses but these were underpowered for meta-regression. In addition, only one study matched for important confounders like vascular risk factors so that sensitivity analysis for risk factors was not possible, and of course hypertension was generally more prevalent in severe WMH groups. Moreover, data for other imaging changes like lacunes or lacunar lesions are lacking. ADDIN EN.CITE <EndNote><Cite><Author>Kobayashi</Author><Year>1991</Year><RecNum>2679</RecNum><DisplayText><style face="superscript">30</style></DisplayText><record><rec-number>2679</rec-number><foreign-keys><key app="EN" db-id="zpdv0e098attenedfv1pfefqpxar9e5a20ez" timestamp="1422376168">2679</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Kobayashi, S.</author><author>Okada, K.</author><author>Yamashita, K.</author></authors></contributors><auth-address>Kobayashi,S. Third Department of Internal Medicine, Shimane Medical University, Japan.</auth-address><titles><title>Incidence of silent lacunar lesion in normal adults and its relation to cerebral blood flow and risk factors</title><secondary-title>Stroke</secondary-title></titles><periodical><full-title>Stroke</full-title><abbr-1>Stroke; a journal of cerebral circulation</abbr-1></periodical><pages>1379-83</pages><volume>22</volume><number>11</number><dates><year>1991</year></dates><accession-num>1750045</accession-num><urls><related-urls><url> Technologies</remote-database-provider></record></Cite></EndNote>30 The meta-analysis demonstrated that CBF measured concurrently was significantly lower in patients with more severe WMH. Cross-sectional studies which only did regression/correlation analyses also showed an association between high WMH burden and low CBF. However, the differences between groups in most brain regions were largely attenuated by excluding dementia and non-age-matched studies, except global mean CBF and CBF in centrum semiovale which remained significant and the point estimate did not move. These results suggest that disease severity and age confound the relationship between WMH and CBF, which was again supported by results from longitudinal studies showing that high burden of WMH predated falling CBF.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj52YW4gZGVyIFZlZW48L0F1dGhvcj48WWVhcj4yMDE1PC9Z
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ADDIN EN.CITE.DATA 10 Additionally, in regression/correlation-only cross-sectional studies where a negative association between WMH and CBF was found, the correlation tends to be significant in more severe patients.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Uem91cmlvPC9BdXRob3I+PFllYXI+MjAwMTwvWWVhcj48
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ADDIN EN.CITE.DATA 37 These results indicate that the reduced CBF in patients with WMH might reflect a reduction in the blood supply required by the tissue, due to reduced neuronal activity, or atrophy with fewer cells. As most included studies recorded CBF in cortical grey matter, these associations between reduced CBF and cortical atrophy should not be overlooked. Cortical atrophy is known to occur with the aging process. Results from a large cohort study demonstrated that baseline brain atrophy predicted decline in total CBF over time.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5ab25uZXZlbGQ8L0F1dGhvcj48WWVhcj4yMDE1PC9ZZWFy
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ADDIN EN.CITE.DATA 49 There are many imaging studies reporting an association between cortical atrophy and WMH severity.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5TY2htaWR0PC9BdXRob3I+PFllYXI+MjAwNTwvWWVhcj48
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AAAAAA==
ADDIN EN.CITE.DATA 25 The contradictory results from white matter indicate that there might be differential vulnerability for DWMH and PVWMH as these two brain areas are on different sections of the arteriolar tree.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5PJmFwb3M7U3VsbGl2YW48L0F1dGhvcj48WWVhcj4yMDAy
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AAAAAA==
ADDIN EN.CITE.DATA 25 However, such a suggestion is not supported by available data - studies indicate that PVWMH and DWMH are on a continuum in terms of location.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5SeXU8L0F1dGhvcj48WWVhcj4yMDE0PC9ZZWFyPjxSZWNO
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ADDIN EN.CITE.DATA 51 The limitation of resting CBF is that it only provides information of a cut-off time point at which CBF might still to be relatively preserved or compensated especially in the early stage of disease.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Pc3RlcmdhYXJkPC9BdXRob3I+PFllYXI+MjAxNTwvWWVh
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ADDIN EN.CITE.DATA 52 One of the included studies showed a reduced CBF response to hypercapnia in non-demented hypertensive patients with leukoaraiosis while resting CBF was shown to be unaffected.PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5LdXdhYmFyYTwvQXV0aG9yPjxZZWFyPjE5OTY8L1llYXI+
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ADDIN EN.CITE.DATA 6 Reduced cerebral vascular reactivity (CVR) represents the dilatory ability of brain vessels, has been suggested as an alternative mechanism of SVD. Risk factors such as hypertension alter the structure of penetrating arterioles by promoting lipohyalinosis and vessel wall thickening, which has led to the suggestion that cerebral arterioles might become stiffer and thus cause a decrease in vasodilatory capacity. Evidences from other studies also suggest that the reduction in CVR might play a critical role in the disease process of SVD. ADDIN EN.CITE <EndNote><Cite><Author>Liem</Author><Year>2009</Year><RecNum>5241</RecNum><DisplayText><style face="superscript">53</style></DisplayText><record><rec-number>5241</rec-number><foreign-keys><key app="EN" db-id="zpdv0e098attenedfv1pfefqpxar9e5a20ez" timestamp="1446079455">5241</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Liem, M. K.</author><author>Lesnik Oberstein, S. A.</author><author>Haan, J.</author><author>Boom, Rv</author><author>Ferrari, M. D.</author><author>Buchem, M. A.</author><author>Grond, Jv</author></authors></contributors><auth-address>Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands. m.k.liem@lumc.nl</auth-address><titles><title>Cerebrovascular reactivity is a main determinant of white matter hyperintensity progression in CADASIL</title><secondary-title>AJNR Am J Neuroradiol</secondary-title></titles><periodical><full-title>AJNR Am J Neuroradiol</full-title></periodical><pages>1244-7</pages><volume>30</volume><number>6</number><keywords><keyword>Adult</keyword><keyword>CADASIL/*complications/*pathology</keyword><keyword>Cerebrovascular Disorders/*complications/*diagnosis</keyword><keyword>Disease Progression</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Magnetic Resonance Imaging/*methods</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Nerve Fibers, Myelinated/*pathology</keyword><keyword>Reproducibility of Results</keyword><keyword>Sensitivity and Specificity</keyword></keywords><dates><year>2009</year><pub-dates><date>Jun</date></pub-dates></dates><isbn>1936-959X (Electronic)
0195-6108 (Linking)</isbn><accession-num>19270103</accession-num><urls><related-urls><url> Further studies are required to investigate how blood flow responsiveness (not just resting CBF) varies across different tissues (NAWM, WMHs and grey matter), and how it changes across the course of the disease.In conclusion, despite large heterogeneities across included studies and the cross-sectional nature of most studies, this systematic review showed that CBF was negatively related to WMH severity. Our results suggest that hypoperfusion in the whole brain and low cortical blood flow is more likely a consequence of WMH than the cause. However, whether WMH are due to focal ischemia in particular white matter tissues and whether development of PVWMHs and DWMHs differ in mechanisms still remain unanswered. This systematic review emphasizes that more data are needed for white matter, especially separate data for NAWM and WMH. Future studies should obtain longitudinal data from white matter as well as grey matter, have larger sample sizes, include appropriate control groups, stratify by and adjust for important cofounders such as age, important risk factors like hypertension, clinical diagnosis, (including the type of dementia if relevant) by different features and severities of SVD, and by cognitive status. In addition, if studying patients with acute stroke, it would be better to avoid the acute phase after stroke for imaging assessments to avoid effects of the acute stroke interfering with the study of WMH. Moreover, investigation of alternative mechanisms such as impaired CVR and effects of blood-brain barrier changes should be pursued in parallel with CBF measurement to provide new perspectives on treatment for SVD.Acknowledgments We thank Dr Francesca Chappell and Dr Emily Sena for providing advice on statistical analysis.Author Contribution statementS.D.M. and J.M.W. conceived the idea of the study. Y.S. and J.M.W. designed the study. Y.S. did the data search and extracted data and statistical analyses. A.J.M.D.C. (now deceased), M.A.VB., and M.I.G. provided unpublished data for two longitudinal studies. J.M.W. cross-checked the data. Y.S. drafted the report and designed the tables and figures. J.M.W., M.J.T., S.M., I.M., A.J.M.D.C., M.A.VB., and M.I.G. revised the report. All authors approved the manuscript. We regret to report the sudden death of A.J.M.D.C. who is sorely missed and to whom this paper is dedicated.FundingThe author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: Y.S. is funded by China Scholarships Council. M.J.T is funded by NHS Lothian Research and Development Office. A.J.M.DC. was and M.A.VB. is an investigator of PROSPER study which was sponsored by an investigator-initiated grant from Bristol Myers-Squibb (Princeton, NJ). J.M.W was supported by the Scottish Funding Council and Chief Scientist Office through the Scottish Imaging Network A Platform for Scientific Excellence (SINAPSE), the Wellcome Trust and the Medical Research Council through the Centre for Cognitive Ageing and Cognitive Epidemiology (CCACE). The authors hold the data independently of funders. Declaration of conflicting interestsThere is no conflict of interest. Supplementary material for this paper is available at: ADDIN EN.REFLIST 1.Wardlaw JM, Smith EE, Biessels GJ, et al. Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration. Lancet Neurol 2013;12:822-38.2.Jeerakathil T, Wolf PA, Beiser A, et al. Stroke risk profile predicts white matter hyperintensity volume: the Framingham Study. Stroke 2004;35:1857-61.3.Yata K, Tomimoto H. Chronic cerebral hypoperfusion and dementia. Neurol Clin Neurosci 2014;2:129-34.4.Potter GM, Doubal FN, Jackson CA, Sudlow CLM, Dennis MS, Wardlaw JM. Lack of Association of White Matter Lesions with Ipsilateral Carotid Artery Stenosis. Cerebrovascular Diseases 2012;33:378-84.5.Ibayashi S, Nagao T, Kuwabara Y, Sasaki M, Fujishima M. Mechanism for decreased cortical oxygen metabolism in patients with leukoaraiosis: Is disconnection the answer? J Stroke Cerebrovasc Dis 2000;9:22-6.6.Kuwabara Y, Ichiya Y, Sasaki M, et al. Cerebral blood flow and vascular response to hypercapnia in hypertensive patients with leukoaraiosis. Ann Nucl Med 1996;10:293-8.7.Stroup DF, Berlin JA, Morton SC, et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. JAMA 2000;283:2008-12.8.Wardlaw JM, Smith EE, Biessels GJ, et al. Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration. Lancet Neurology 2013;12:822-38.9.Bailey EL, Smith C, Sudlow CL, Wardlaw JM. Pathology of lacunar ischemic stroke in humans--a systematic review. Brain Pathol 2012;22:583-91.10.van der Veen PH, Muller M, Vincken KL, et al. Longitudinal relationship between cerebral small-vessel disease and cerebral blood flow: the second manifestations of arterial disease-magnetic resonance study. Stroke 2015;46:1233-8.11.Bisschops RHC, Van Der Graaf Y, Mali WPTM, Van Der Grond J. High total cerebral blood flow is associated with a decrease of white matter lesions. J Neurol 2004;251:1481-5.12.Ten Dam VH, Van Den Heuvel DMJ, De Craen AJM, et al. Decline in total cerebral blood flow is linked with increase in periventricular but not deep white matter hyperintensities. Radiology 2007;243:198-203.13.van Es AC, van der Grond J, ten Dam VH, et al. Associations between total cerebral blood flow and age related changes of the brain. PLoS One 2010;5:e9825.14.Vernooij MW, van der Lugt A, Ikram MA, et al. Total cerebral blood flow and total brain perfusion in the general population: the Rotterdam Scan Study. J Cereb Blood Flow Metab 2008;28:412-9.15.Claus JJ, Breteler MM, Hasan D, et al. Vascular risk factors, atherosclerosis, cerebral white matter lesions and cerebral perfusion in a population-based study. Eur J Nucl Med 1996;23:675-82.16.Kimura N, Nakama H, Nakamura K, Aso Y, Kumamoto T. Effect of white matter lesions on brain perfusion in alzheimer's disease. Dement Geriatr Cogn Disord 2012;34:256-61.17.Yamaji S, Ishii K, Sasaki M, et al. Changes in cerebral blood flow and oxygen metabolism related to magnetic resonance imaging white matter hyperintensities in Alzheimer's disease. J Nucl Med 1997;38:1471-4.18.Schuff N, Matsumoto S, Kmiecik J, et al. Cerebral blood flow in ischemic vascular dementia and Alzheimer's disease, measured by arterial spin-labeling magnetic resonance imaging. Alzheimers Dement 2009;5:454-62.19.Kawamura J, Meyer JS, Ichijo M, Kobari M, Terayama Y, Weathers S. Correlations of leuko-araiosis with cerebral atrophy and perfusion in elderly normal subjects and demented patients. J Neurol Neurosurg Psychiatry 1993;56:182-7.20.Kobari M, Meyer JS, Ichijo M, Oravez WT. Leukoaraiosis: Correlation of MR and CT findings with blood flow, atrophy, and cognition. AJNR Am J Neuroradiol 1990;11:273-81.21.Nezu T, Yokota C, Uehara T, et al. Preserved acetazolamide reactivity in lacunar patients with severe white-matter lesions: 15 O-labeled gas and H 2 O positron emission tomography studies. J Cereb Blood Flow Metab 2012;32:844-50.22.Zheng LS, Xu J, Wang JP. Quantitative evaluation of regional cerebral blood flow in patients with silent Leukoaraiosis. [Chinese]. Chinese Journal of Clinical Rehabilitation 2006;10:80-2.23.Ramli N, Ho KL, Nawawi O, Chong HT, Tan CT. CT perfusion as a useful tool in the evaluation of leuko-araiosis. Biomed Imaging Interv J 2006;2: doi:10.2349/biij.2.2.e16.24.Cui BW, Qi X, Guo HZ. Comparative study on the cerebral hemodynamics changes between Leukoaraiosis and Binswanger disease. [Chinese]. Chinese Journal of Clinical Rehabilitation 2003;7:3460-1.25.O'Sullivan M, Lythgoe DJ, Pereira AC, et al. Patterns of cerebral blood flow reduction in patients with ischemic leukoaraiosis. Neurology 2002;59:321-6.26.Yao H, Yuzuriha T, Fukuda K, et al. Cerebral blood flow in nondemented elderly subjects with extensive deep white matter lesions on magnetic resonance imaging. J Stroke Cerebrovasc Dis 2000;9:172-5.27.Markus HS, Lythgoe DJ, Ostegaard L, O'Sullivan M, Williams SCR. Reduced cerebral blood flow in white matter in ischaemic leukoaraiosis demonstrated using quantitative exogenous contrast based perfusion MRI. J Neurol Neurosurg Psychiatry 2000;69:48-53.28.Oishi M, Mochizuki Y. Differences in regional cerebral blood flow in two types of leuko- araiosis. J Neurol Sci 1999;164:129-33.29.Hatazawa J, Shimosegawa E, Satoh T, Toyoshima H, Okudera T. Subcortical hypoperfusion associated with asymptomatic white matter lesions on magnetic resonance imaging. Stroke 1997;28:1944-7.30.Kobayashi S, Okada K, Yamashita K. Incidence of silent lacunar lesion in normal adults and its relation to cerebral blood flow and risk factors. Stroke 1991;22:1379-83.31.Fazekas F, Niederkorn K, Schmidt R, et al. White matter signal aities in normal individuals: Correlation with carotid ultrasonography, cerebral blood flow measurements, and cerebrovascular risk factorsbnormal. Stroke 1988;19:1285-8.32.Kimura M, Shimoda K, Mizumura S, et al. Regional cerebral blood flow in vascular depression assessed by 123I-IMP SPECT. J Nippon Med Sch 2003;70:321-6.33.Fu J, Tang J, Han J, Hong Z. The reduction of regional cerebral blood flow in normal-appearing white matter is associated with the severity of white matter lesions in elderly: A xeon-ct study. PLoS ONE 2014;9. doi:10.1371/journal.pone.0112832.34.De Bastos-Leite AJ, Kuijer JPA, Rombouts SARB, et al. Cerebral blood flow by using pulsed arterial spin-labeling in elderly subjects with white matter hyperintensities. AJNR Am J Neuroradiol 2008;29:1296-301.35.Miyazawa N, Satoh T, Hashizume K, Fukamachi A. Xenon contrast CT-CBF measurements in high-intensity foci on T2-weighted MR images in centrum semiovale of asymptomatic individuals. Stroke 1997;28:984-7.36.Huynh TJ, Murphy B, Pettersen JA, et al. CT perfusion quantification of small-vessel ischemic severity. AJNR Am J Neuroradiol 2008;29:1831-6.37.Tzourio C, Levy C, Dufouil C, Touboul PJ, Ducimetiere P, Alperovitch A. Low cerebral blood flow velocity and risk of white matter hyperintensities. Ann Neurol 2001;49:411-4.38.Heliopoulos I, Artemis D, Vadikolias K, Tripsianis G, Piperidou C, Tsivgoulis G. Association of ultrasonographic parameters with subclinical white-matter hyperintensities in hypertensive patients. Cardiovasc Psychiatry Neurol 2012. doi:10.1155/2012/616572.39.Isaka Y, Okamoto M, Ashida K, Imaizumi M. Decreased cerebrovascular dilatory capacity in subjects with asymptomatic periventricular hyperintensities. Stroke 1994;25:375-81.40.Alosco ML, Brickman AM, Spitznagel MB, et al. Cerebral perfusion is associated with white matter hyperintensities in older adults with heart failure. Congest Heart Fail 2013;19:E29-E34.41.Ott BR, Faberman RS, Noto RB, et al. A SPECT imaging study of MRI white matter hyperintensity in patients with degenerative dementia. Dement Geriatr Cogn Disord 1997;8:348-54.42.Bisschops RH, van der Graaf Y, Mali WP, van der Grond J, group Ss. High total cerebral blood flow is associated with a decrease of white matter lesions. J Neurol 2004;251:1481-5.43.Bernbaum M, Menon BK, Fick G, et al. Reduced blood flow in normal white matter predicts development of leukoaraiosis. J Cereb Blood Flow Metab 2015;35:1610-5.44.Kraut MA, Beason-Held LL, Elkins WD, Resnick SM. The impact of magnetic resonance imaging-detected white matter hyperintensities on longitudinal changes in regional cerebral blood flow. J Cereb Blood Flow Metab 2008;28:190-7.45.Wagner M, Helfrich M, Volz S, et al. Quantitative T2, T2*, and T2' MR imaging in patients with ischemic leukoaraiosis might detect microstructural changes and cortical hypoxia. Neuroradiology 2015;57:1023-30.46.Claus JJ, Breteler MMB, Hasan D, et al. Vascular risk factors, atherosclerosis, cerebral white matter lesions and cerebral perfusion in a population-based study. Eur J Nucl Med 1996;23:675-82.47.Crane DE, Black SE, Ganda A, et al. Grey matter blood flow and volume are reduced in association with white matter hyperintensity lesion burden: A cross-sectional MRI study. Front Aging Neurosci 2015;7. doi:10.3389/fnagi.2015.00131.48.Vernooij MW, Van Der Lugt A, Ikram MA, et al. Total cerebral blood flow and total brain perfusion in the general population: The Rotterdam Scan Study. J Cereb Blood Flow Metab 2008;28:412-9.49.Zonneveld HI, Loehrer EA, Hofman A, et al. The bidirectional association between reduced cerebral blood flow and brain atrophy in the general population. J Cereb Blood Flow Metab 2015;35:1882-7.50.Schmidt R, Ropele S, Enzinger C, et al. White matter lesion progression, brain atrophy, and cognitive decline: The Austrian Stroke Prevention Study. Ann Neurol 2005;58:610-6.51.Ryu WS, Woo SH, Schellingerhout D, et al. Grading and interpretation of white matter hyperintensities using statistical maps. Stroke 2014;45:3567-75.52.?stergaard L, Engedal TS, Moreton F, et al. Cerebral small vessel disease: Capillary pathways to stroke and cognitive decline. J Cereb Blood Flow Metab 2016;2:302-25.53.Liem MK, Lesnik Oberstein SA, Haan J, et al. Cerebrovascular reactivity is a main determinant of white matter hyperintensity progression in CADASIL. AJNR Am J Neuroradiol. 2009;30:1244-7.Figure legendsFigure 1. PRISMA flow diagram of literature searchFigure 2a. Forest plot showing standard mean differences in global and grey matter CBF in patients with WMH in dementia & non-dementia studies. CBF in different brain regions were analysed in subgroups. CBF: cerebral blood flow.Figure 2b. Forest plot showing standard mean differences in white matter CBF in patients with WMH in dementia & non-dementia studies. CBF in different brain regions were analysed in subgroups. CBF: cerebral blood flow; WMH: white matter hyperintensities.Figure 3. Sensitivity analysis: standard mean differences (SMD) of CBF in different brain areas in patients with moderate to severe WMH against those with negative to mild WMH. In each brain area, we showed the SMD of CBF in all studies, after excluding dementia studies and furthermore excluding studies without age-matching [number of studies] (number of participants). CBF: cerebral blood flow; GM: grey matter; WM: white matter; WMH: white matter hyperintensities; CI: confidence interval.Table 1. Characteristics of all included studiesStudySample sizeParticipants(Baseline) Age (years, mean ± S.D.)Methods of measuring CBFCBF unitsLongitudinal studies (4) Bernbaum 201540High risk TIA or minor ischemic stroke61.0±11.0DCS PWIml/100g/min van der Veen 2015575Manifest arterial diseases*57.0±10.0Phase-contrast MRIml/100ml/min Kraut 200874Progressive WMH70.0±6.9PETNot shownStable WMH67.1±7.0 Ten Dam 2007390history of vascular disease or were at increased vascular risk75.0±3.2Phase-contrast MRIml/minCross-sectional studies (34) Cognitive impairment/Dementia (6)Kimura, N. 201298late-onset AD with WMH78.6±5.1SPECTml/100g/minAD without WMH77.4±5.0Schuff 200926subcortical vascular dementia 77.0±8.0 ASLml/100g/mincognitively normal73.0±8.0Ibayashi 200015dementia of BD60.0±2.0PETml/100ml/minage-matched hypertensive controls59.0±2.0Yamaji 199732AD with WMH 71.6±3.1PETml/100ml/minAD without WMH71.0±4.3Kawamura 199340MID64.4±10.2Xenon CTml/100g/minno WMH67.2±10.5Kobari 199020MID 68.1±12.0Xenon CTml/100g/minneurologically normal controls52.3±5.7 No cognitive impairment (18)Wagner 201536Extensive WMH71.0ASLml/100g/minNo or mild WMH67.0 Fu 201456WMH Grade 3?68.1±8.1Xenon CTml/100g/minWMH Grade 268.9±7.7WMH Grade 164.5±5.8WMH Grade 065.3±6.3Nezu 201218lacunar stroke with severe WMHs76.0PETml/100g/minlacunar stroke with mild WMH74.0Huynh 200835TIA with moderate to severe WMH77.1±6.0CT perfusionml/100 g/minTIA with mild WMH62.6±16.3De Bastos-Leite 200821WMH Grade 3?77.7±5.7ASLml/100ml/minWMH Grade 274.4±4.6WMH Grade 174.0±5.0Zheng 200635asymptomatic WMH69.7±8.9SPECTml/g/minno WMH67.1±6.9Ramli 200642leukoraiosis on CT 70.19CT perfusionml/100g/minno leukoraiosis on CT69.86Kimura, M. 200320depression (remission) with WMH78.5±5.1SPECTml/100g/mindepression (remission) without WMH77.4±5.0Cui 200398WMH70.0TCD, SPECTcm/sno WMH66.0O'Sullivan 200236WMH68.9±9.2PETml/100g/minno WMH72.7±7.7Yao 200010extensive WMH75.0±5.0Xenon CTml/100g/minno WMH72.0±5.0Markus 200017Leukoraiosis 63.3±12.3MRI Contrastml/100g/minno leukoraiosis68.3±7.3Oishi 199945WMH66.8±8.4Xenon CTml/100g/minno WMH65.1±8.5Hatazawa 199733asymptomatic WMH71.3±8.6PETml/100ml/minno WMH68.5±10.2Miyazawa 1997135WMH Grade IV?71.90±8.17Xenon CTml/100g/minWMH Grade III69.00±8.08WMH Grade II67.30±9.87WMH Grade I64.20±5.55WMH Grade 057.3±12.0Kuwabara 199624hypertensive with moderate to severe leukoraiosis? 67.0±9.0PETml/100ml/minHypertensive with negative to mild leukoraiosis54.0±7.0normotensive control60.0±12.0Kobayashi 1991246apparent PVWMH67.0±6.1Xenon CTml/100g/minno or mild PVWMH60.0±8.2Fazekas 198823WMH 58.8±5.3Xenon CTml/100g/minno WMH58.2±2.8Studies only showing correlation coefficients (10)Crane 201526Mild to severe WMH73.3±8.8ASLml/100g/minAlosco 201369Heart failure with WMH68.55±8.07Ultrasound Dopplercm/sHeliopoulos 201252Hypertension with WMH71.4±4.5Ultrasound Dopplercm/svan Es 2010447Cerebrovascular risk factors without major neurological deficits75.0±3.0Phase-contrast MRIml/min, ml/100ml/minVernooij 2008892Population-based 67.5±5.5Phase-contrast MRIml/100g/minBisschops 2004228Manifest arterial diseases*59.0Phase-contrast MRIml/minTzourio 2001628Population-based68.9±2.9Ultrasound Dopplerm/sOtt 199740Mixed dementia72.8±8.7SPECT%rCBF relative to cerebellumClaus 199660Non-demented WMH65.0-85.0§SPECT%rCBF relative to cerebellumIsaka 199428Cerebrovascular risk factors without neurological deficits67.8Xenon CTml/100ml/minS.D.: standard deviation; CBF: cerebral blood flow; TIA: transient ischemic attack; DCS-PWI: dynamic susceptibility contrast perfusion-weighted imaging; MRI: magnetic resonance imaging; AD: Alzheimer’s disease; MID: multi-infarct dementia; BD: Binswanger’s disease; WMH: white matter hyperintensities; SPECT: Single-photon emission computed tomography; ASL: Arterial spin labelling MRI; PET: positron emission tomography; TCD: Transcranial Doppler; CT: computed tomography; PVWMH: periventricular white matter hyperintensities; rCBF: regional cerebral blood flow. * Include manifest coronary artery disease, cerebrovascular disease, peripheral arterial disease or an abdominal aortic aneurysm. ? Fazekas WMH score; ? Self-designed scoring system for WMH; § Age rangeTable 2. Results of association-only cross-sectional studiesStudySample sizeStatistical methodResultsP ValuesAdjusted for other variablesVariablesCoefficientsCrane 201526Partial correlation (post-hoc test)Mean CBF in cluster (LAP, SC, accumbens, AC and OF) and Fazekas scoreRho=-0.550.006Age, genderMean CBF in cluster (LAI and OF) and Fazekas scoreRho=-0.490.015Mean CBF in cluster (LOF and FP) and Fazekas scoreRho=-0.560.005Alosco 201369Multivariable hierarchical regressionCBFv and WMH volumeβ=-0.340.02Age, gender, premorbid intelligence,depressive symptoms, BMI, hypertension, diabetes, thyroidabnormalities, intracranial volumeHeliopoulos 201252Spearman rank-order correlationCCA-PSV and WMH scorer=-0.2560.067NoCCA-EDV and WMH scorer=-0.2050.144CCA-MFV and WMH scorer=-0.1340.342ICA-PSV and WMH scorer=-0.1350.341ICA-EDV and WMH scorer=-0.3240.019ICA-MFV and WMH scorer=-0.3630.008van Es 2010447Linear regression modeltCBF and WMH volumer=-0.0690.148NoTCBF and WMH volumer=-0.1060.044Vernooij 2008892Linear regression modelWMH volume and tCBF0.03* NSAge, genderWMH volume and TCBF0.07 ? SignificantBisschops 2004282Linear regression modelWMH score and tCBF–1.0? 0.041Age, gender, IMT, hypertensionTzourio 2001628Multiple logistic regressionQuartiles of mean CBFv and WMHOR=1.4 (1st quartile)0.22age, gender, BMI, hypertension, diabetes, hematocrit,IMTOR=1.6 (2nd quartile)0.11OR=2.3 (3rd quartile)0.006Ott 199740Spearman rank-order correlation Perfusion score and PVWMHscorer=-0.170.3NoPerfusion score and SCWMH scorer=-0.130.42Claus 199660Multiple linear regression modelCBF and grades of severity of WMH-1.7§ (Frontal lobe)NSage, gender, type of SPET camera and ventricle-to-brain ratio0.4§ (Parietal lobe)NS1.2§ (Temporo-parietal area)NS-0.4§ (Temporal lobe)NSIsaka 199428Spearman rank-order correlationPVWMH score and baseline CBF r=-0.364NSNoLAP: left anterior putamen; SC: subcallosal; AC: anterior caudate; OF: orbital frontal; LAI: left anterior insula; LOF: left orbital; FP: frontal pole; CBFv: cerebral blood flow velocity (measured by Ultrasound Doppler); WMH: white matter hyperintensities; BMI: Body mass index; CCA: common carotid artery; ICA: internal carotid artery; PSV: peak systolic velocity; EDV: end-diastolic velocity; MFV: mean-flow velocity; tCBF: total cerebral blow flow in ml/min; TCBF: cerebral blood flow per 100mL brain volume; total brain perfusion: tCBF devided by brain volume; S.D.: standard deviation; lnWMH: natural log transformed white matter hyperintensities volume; IMT: intima media thickness; OR: odds ratio; PVWMH: periventricular white matter hyperintensities; SCWMH: subcortical white matter hyperintensities; NS: not significant; SPET: single-positron emission tomography. * Difference in lnWMH volume per S.D. increase of tCBF; ? Difference in lnWMH volume per S.D. decrease in TCBF; ? Difference in WMH per 100ml/min increase in tCBF; § Difference in % CBF between persons with no/slight WMH and persons with moderate/severe WMH.Table 3. Results of longitudinal studiesBernaum 2015Van der veen 2015Kraut 2008*Ten Dam 2007Sample size4057574390Follow-up time (years)1.53.97.72.75CBFat baseline16.0±0.2 ? (ml/100g/min)52.3±9.8 (ml/100ml/min)NA520.0±88.0 (ml/min)at follow-upNANA504.0±92.0 (ml/min)WMH (ml)at baseline9.21±11.872.86±5.445.27±9.60at follow-up11.96±13.163.74±7.667.48±11.70Association analysisbCBF and bWMH volumeCoefficientNANANATWMH: OR=1.02 [95%CI: 0.86, 1.21];PVWMH: OR=1.03 [95%CI: 0.87, 1.21]TWMH: OR=0.88 [95%CI: 0.74, 1.06]P valueNSbCBF and ΔWMH volumeCoefficientOR=0.61 [95%CI: 0.57, 0.65]PVWMH: B?=0.00 [95%CI: -0.06, 0.05]DWMH: B? =0.04 [95%CI: -0.04, 0.12]NAP value<0.001NSbWMH volume and ΔCBFCoefficientNAPVWMH: B§ =-0.61 [95%CI: -1.32, 0.10]DWMH: B§ =-0.92 [95%CI: -1.56, -0.28]NAP valuePVWMH: NSDWMH: <0.05 ΔWMH volume and ΔCBFCoefficientNAr=-0.37TWMH: OR=1.17 [95%CI: 0.84, 1.46];PVWMH: OR=1.32 [95%CI: 1.06, 1.66];DWMH: OR=1.00 [95%CI: 0.79, 1.25]P valueNSTWMH: NSPVWMH: 0.015DWMH: NSAdjusted for other variablesAge, sex, diabetes, hypertensionAge, sex, follow-up periods, baseline WMHs, cardiovascular risk factors, IMT, carotid stenosis >50%, non lacunesAge, sex, baseline atrophy, treatment allocation, baseline CBFCBF value and WMH volume at both baseline and follow-up, and results of association analysis in longitudinal studies. CBF: cerebral blood flow; WMH: white matter hyperintensities; PVWMH: periventricular white matter hyperintensities; DWMH: deep white matter hyperintensities; TWMH: total white matter hyperintensities; bCBF: baseline CBF; bWMH: baseline white matter hyperintensities; ΔWMH: change of white matter hyperintensities; ΔCBF: change of cerebral blood flow; OR: odds ratio; CI: confidence interval; NA: not available; NS: not significant; IMT: intima media thickness. No numeric data were available from this paper as statistical parametric mapping methods was used as the image analysis tool;? CBF of tissues which were normal appearing white matter at baseline but became WMH at follow-up;? % change in PVWMH or DWHMs-natural log transformed (% intracranial volume, ICV) per decrease in baseline CBF;§ Absolute change in CBF per % ICV PVWMH or DWMH (natural log transformed) at baseline ................
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