ASMS Pharmacodynamic Biomarker of Treatment with ...

Optimization and Validation of a LC-MS/MS Method for Peripheral Serotonin (5-HT) as a Pharmacodynamic Biomarker of Treatment with Tryptophan Hydroxylase Inhibitors

Katelyn Reighard Crizer1, Fran?ois Viel2, Fran?ois Samson Thibault2, Michelle Palacios1, and Stephen Wring1

1Altavant Sciences, Inc., 6501 Weston Parkway, Suite 330, Cary, NC, Health, 2 USA; 2Syneos 500 Rue Einstein, Qu?bec City, QC, Canada

ASMS Atlanta, GA

2019

Background

Pulmonary arterial hypertension (PAH) is a progressive disorder with a median survival ................
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