Influence of treatment with Continuous Erythropoietin ...



Abstract

Aim of the study: We investigated in a prospective, non randomized, controlled study a possible direct effect of C.E.R.A. on markers of endothelial dysfunction, inflammation and malnutrition in chronic kidney disease (CKD) patients.

Materials and Methods: Routine parameters and markers of inflammation and endothelial dysfunction were dosed before (T0), after three (T1) and six months (T2) of treatment with C.E.R.A. (mean dose 98,33±4,6 mcg month), and again after three (T3) and six (T4) months of α-darboepoetin (mean dose 27,30±3,60 µg/week) in 60 stage 3 and 4 CKD patients on stable anemia correction previously achieved with α-darboepoetin.

Results: At 3 (T1) and 6 (T2) months we observed a significant reduction of sHcy (p=0,0011 for T0 vs T1 and 0,001 for T0 vs T2) and hs-CRP (p ................
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