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One meta-analysis of 3 RCTs investigating various selective PDE-5 inhibitors (sildenafil 50 mg twice daily, modified release sildenafil 100 mg/day increased up to 200 mg/day or tadalafil 20 mg on alternate days) in SSc patients with Raynaud’s phenomenon of whom 39 had baseline DUs indicated that selective PDE-5 inhibitors improve healing of ... ................
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