NIOSH List of Antineoplastic and Other Hazardous Drugs in ...

NIOSH List of Antineoplastic

and Other Hazardous Drugs

in Healthcare Settings, 2016

DEPARTMENT OF HEALTH AND HUMAN SERVICES

Centers for Disease Control and Prevention

National Institute for Occupational Safety and Health

NIOSH List of Antineoplastic and Other

Hazardous Drugs in Healthcare Settings, 2016

DEPARTMENT OF HEALTH AND HUMAN SERVICES

Centers for Disease Control and Prevention

National Institute for Occupational Safety and Health

This document is in the public domain and may be freely copied or reprinted.

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Suggested Citation

NIOSH [2016]. NIOSH list of antineoplastic and other hazardous drugs in healthcare settings, 2016. By

Connor TH, MacKenzie BA, DeBord DG, Trout DB, O¡¯Callaghan JP. Cincinnati, OH: U.S. Department of

Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication Number 2016-161 (Supersedes 2014-138).

NIOSH evaluation of hazardous drugs does not cover NIOSH classification of chemical carcinogens.

Although NIOSH hazardous drug evaluation includes consideration of carcinogenicity and genotoxicity, this evaluation is tailored to identify and evaluate data from human toxicity profiles, animal

studies and in vitro studies unique to evaluating therapeutic agents. For example, NIOSH consults a

variety of resources including, but not limited to, safety data sheets, product labeling approved by the

U.S. Food and Drug Administration and databases such as DailyMed and DrugBank. For more information on NIOSH classification of chemical carcinogens see ¡°NIOSH Chemical Carcinogen Policy,¡±

.

DHHS (NIOSH) Publication No. 2016-161

September 2016

ii

List of Acronyms

AHFS

American Hospital Formulary Service

ASHP

American Society of Health-System Pharmacists (formerly, American Society

of Hospital Pharmacy)

BCG

Bacillus Calmette¨CGu¨¦rin

BSC

Biological safety cabinet

CACI

Compounding aseptic containment isolator

CFR

Code of Federal Regulations

CSTD

Closed system drug-transfer device

DPI

Drug package insert

EPA

Environmental Protection Agency

FDA

Food and Drug Administration

HEPA

High-efficiency particulate air

HIPEC

Heated intraperitoneal chemotherapy

IARC

International Agency for Research on Cancer

IV

Intravenous

MRHD

Maximum Recommended Human Dose

MSHG

Manufacturer¡¯s safe handling guidance

NIOSH

National Institute for Occupational Safety and Health

OEL

Occupational exposure limit

OSHA

Occupational Safety and Health Administration

ONS

Oncology Nursing Society

PPE

Personal protective equipment

SC

Subcutaneous

SDS

Safety Data Sheet (formerly Material Safety Data Sheet)

USP

United States Pharmacopeial Convention

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