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Curriculum Vitae

Associate Professor Peter Yiwen LIU

Date of Birth: 25 June 1969

Academic Qualifications

1987-1992 Bachelor of Medicine and Bachelor of Surgery Honours Class I

Faculty of Medicine, University of Sydney (Conferred: 31 April 1993)

1999. Fellow of the Royal Australasian College of Physicians

Royal Australasian College of Physicians, Subspecialty Endocrinology

(Conferred: 23 December 1999)

2003. Doctor of Philosophy

University of Sydney (28 November, 2003)

Thesis Title: “The Clinical Use of Reproductive Hormones in Young and Older Men”

Current Appointment

2003-now Associate Professor and NHMRC Career Development Fellow, Woolcock Research Institute, University of Sydney

(Academic Title of Associate Professor conferred Nov 2006)

2008-now Head, Endocrine and Cardiometabolic Group, Woolcock Research Institute, University of Sydney

2004- Research Collaborator, Division of Endocrinology, Mayo Clinic, Rochester MN USA

Current Clinical Appointments

2006-now Consultant, Concord Hospital (Department of Andrology)

2006-now Consultant, Children’s Hospital at Westmead (Department of Oncology)

2010-now Consultant, Royal Prince Alfred Hospital (Department of Respiratory and Sleep Medicine, and Department of Endocrinology)

Employment History

Jan 1994 – Jan 1997 Resident Medical Officer

Concord Hospital, Concord NSW Australia

Jan 1997 – Jan 1999 Endocrinology Senior Registrar

Royal Prince Alfred Hospital (RPAH), Camperdown NSW Australia

Jan 2003 – Nov 2004 Postdoctoral Research Fellow

Division of Endocrinology, Department of Medicine, Mayo Graduate School of Medicine, Mayo Clinic, Rochester MN, USA

Topic: “Mechanistic bases for Age-Related Androgen deficiency”

Nov 2004 – Feb 2006 Postdoctoral Research Fellow

Division of Endocrinology, Department of Medicine, Harbor -UCLA Medical Center, David Geffen School of Medicine at UCLA; Torrance, CA, USA

Topic: “Sertoli cell dysfunction and impaired spermatogenesis in experimental XXY (Klinefelter Syndrome) mice”

Other Relevant Achievements

(a) Honours and Awards

Highlights

The Young Andrologist award, given by the American Society of Andrology is the premiere award for scientists aged below 45. It is rarely given to clinician scientists, and I am the first overseas based clinician scientist to receive this award in its 28 year history.

I am the 2010 recipient of the mid-career research award, given by the Endocrine Society of Australia, as well as a previous recipient of its young investigator award.

I was ranked first amongst all NHMRC clinical career development award recipients in 2008. I received a level II award even though I was eligible for a level I award.

1987–92 E. Trenchard Miller Memorial Scholarship, University of Sydney

1987–89 James Aitken Scholarship, University of Sydney

1999–03 Medical Postgraduate Scholarship, National Health and Medical Research Council (Australia)

2003 Vincent Fairfax Family Foundation Research Fellowship, Royal Australasian College of Physicians

2003-8 Neil Hamilton Fairley Fellowship (ID 262025). National Health and Medical Research Council (Australia)

2004 Young Investigator Award, Endocrine Society of Australia

2004 Postdoctoral Research Fellowship, Lalor Foundation (USA)

2004 Sir Keith Murdoch Fellowship, American-Australian Association (USA)

2005 Trainee Merit Award, American Society of Andrology (USA)

2007 Outstanding Reviewer Award (Journal of Clinical Endocrinology and Metabolism), US Endocrine Society (USA)

2008 “Rising stars of Australian Endocrinology”, special 50th Anniversary Award lecture, Endocrine Society of Australia and Australian Academy of Science.

2008-11 Level II Career Development Award (ID 511929), National Health and Medical Research Council (Australia)

2010 Young Andrologist, American Society of Andrology (USA)

2010 Mid-Career Research Award, Endocrine Society of Australia.

2010 Finalist, Pfizer Fellowship (3 finalists for 1 award nationwide)

2010 Finalist, Viertel Fellowship (6 finalists for 2 awards nationwide)

Various travel awards from the American Federation of Medical Research, American Society of Andrology, American Society for Bone and Mineral Research and Endocrine Society of Australia.

(c) Review Involvement

Grant Applications

Project Grant Assessor, National Health and Medical Research Council, continuously since 2007

Member, Biomedical Postdoctoral Fellowship Review Panel, National Health and Medical Research Council, since 2010

Ad hoc reviewer, National Heart Foundation of Australia

Ad hoc reviewer, Diabetes Australia Research Trust continuously since 2008

Editorial Board

Asian Journal of Andrology (2005-13)

International Advisory Board

Current Medical Opinion and Research (2007-12)

Journals

Journal of Clinical Endocrinology and Metabolism (“Outstanding Reviewer” award, 2007)

Clinical Endocrinology

Diabetes Care

Human Reproduction

American Journal of Medicine

Asian Journal of Andrology

Atherosclerosis

Biological Psychiatry

British Journal of Pharmacology

Current Medical Opinion and Research

Diabetes, Nutrition and Metabolism

Endocrine Reviews

European Journal of Endocrinology

Expert Opinion on Emerging Drugs

Fertility and Sterility

Human Reproduction Update

Internal Medicine Journal

International Journal of Andrology

Journal of the American Medical Association (JAMA)

Journal of Andrology

Journal of Endocrinology

Journal of Sexual Medicine

Journal of Sleep Research

Journal of Vascular Research

Lancet

Medical Journal of Australia

Modern Medicine

New England Journal of Medicine

PLOS One

Sleep

Meetings

Abstract reviewer, US Endocrine Meeting, continuously since 2006

Judge, Young Investigator’s Award, Fourth International Huaxia Congress of Endocrinology, Hong Kong, 2006.

(d) Scientific Discipline Involvement

Current Society and Professional Membership

1994 - now Registered Medical Practitioner, New South Wales, Australia

1997 - now Member, Endocrine Society of Australia

1999 - now Fellow, Royal Australasian College of Physicians (RACP)

Subspecialty, Endocrinology

1999 - now Member, Endocrine Society (USA)

2005 - now Member, American Society of Andrology (USA)

2007 - now Member, Australian Sleep Association

2009 - now Member, Sleep Research Society (USA)

2009 - now Member, European Sleep Research Society (Europe)

Ongoing Committee Membership

International

2001 - now Member, International Hormonal Male Contraception Summit Group

2007 - now Assistant Secretary, World Federation of Sleep Research and Sleep Medicine Societies

National

2006 - now Member, Development Group, Australasian Sleep Trials Network

2007 - now Member, Klinefelter’s Working Group, Andrology Australia

2008 - now Member, Membership Committee, American Society of Andrology

2009 - now Member, Trainee Affairs Committee, American Society of Andrology

2009 - now Co-chair, personalised medicine group, Australasian Sleep Trials Network

Local

2011- now Chair, Scientific Subcommittee of the Human Ethics Committee (Concord Hospital), Sydney South West Area Health Service

2007- 2011 Deputy Chair, Scientific Subcommittee of the Human Ethics Committee (Concord Hospital), Sydney South West Area Health Service

2007- now Executive Member, Sleep and Circadian Group, Woolcock Institute of Medical Research

2009- now Member, Education Committee, Woolcock Institute of Medical Research

2010- now Member, Mentoring Program, Sydney Medical School, University of Sydney

2010- now Member, Centre for Obesity, Diabetes and Cardiovascular Disease Clinical Research Facility and Device Discovery Design User Group, Sydney Medical School, University of Sydney

Previous Committee Membership

International

2001 Temporary Advisor, Committee on Hormonal Male Contraception, World Health Organisation, Research Area for Male Reproductive Health Special Programme of Research, Development and Research Training in Human Reproduction, Department of Reproductive Health and Research (RHR), Geneva, Switzerland.

2002 Temporary Advisor, Committee on Hormonal Male Contraception, World Health Organisation, Research Area for Male Reproductive Health Special Programme of Research, Development and Research Training in Human Reproduction, Department of Reproductive Health and Research (RHR), Geneva, Switzerland.

National

1999 Ad Hoc Member (representing the Endocrine Society of Australia), Australian Pharmaceutical Manufacturers Association Monitoring Committee, Australia.

Local

2003 Steering Committee Member, Mayo Research Fellows Forum, Mayo Clinic, Rochester, MN, USA.

2004 Treasurer and Executive Committee Member, Mayo Research Fellows Association, Mayo Clinic, Rochester, MN, USA.

2007-8 Deputy Chair, Clinical Trials Subcommittee of the Human Ethics Committee (Royal Prince Alfred Hospital), Sydney South West Area Health Service

National/International Profile

Invited speaker at a major international meeting:

“Randomised, placebo-controlled clinical trial of recombinant hcg on muscle mass, strength and physical activity in older men”, Clinical Trials Symposium, American Endocrine Society 83rd Annual Meeting, Denver CO, June 2001. (Registration waived. No other financial compensation, because of Endocrine Society policy on members presenting at the annual scientific meeting)

“Efficacy, safety and service feasibility of an androgen/progestin depot regimen for hormonal contraception”, 5th International Summit Meeting on Hormonal Male Contraception, Geneva, Switzerland, July 2001.

“The acute effects of high dose testosterone on sleep in ageing men”, Clinical Trials Symposium, American Endocrine Society 84th Annual Meeting, San Francisco CA, June 2002. (Registration waived. No other financial compensation, because of Endocrine Society policy on members presenting at the annual scientific meeting)

“Efficacy, safety and service feasibility of an androgen/progestin depot regimen for hormonal contraception”, 6th International Summit Meeting on Hormonal Male Contraception, Bonn, Germany, July 2002. (Attendance fully paid)

“Androgens and body composition in male ageing”, Male Ageing Symposium, First Asia-Pacific Forum on Andrology, Shanghai, China, October 2002. (Attendance fully paid)

“Androgens and Male Ageing”, Male Ageing Plenary, Second Asia-Pacific Forum on Andrology, Shanghai, China, October 2006. (Attendance fully paid)

“Factors Influencing Suppression of Spermatogenesis with Male Hormonal Contraceptive Methods”, 10th International Summit Meeting on Hormonal Male Contraception, New York City, USA, October 2006.

“Age-related relative testosterone deficiency: pathophysiology and interim management guidelines”, Male Ageing Symposium, Fourth International Huaxia Congress of Endocrinology, Hong Kong, China, December 2006. (Attendance fully paid)

“Androgen effects on sleep and sleep disordered breathing”, Reproductive Endocrinology of Sleep, Sleep Disordered Breathing and Ageing Symposium, World Sleep 07, World Congress of the Federation of Sleep Research and Sleep Medicine Societies, Cairns, Australia, September 2007.

“Recovery of spermatogenesis following male hormonal contraception”, Opening Symposium Speaker, 2nd National Institutes of Health Future of Male Contraception Conference, Seattle, WA, September 2007.

“Alternative therapies of secondary hypogonadism”, Clinical Disorders of the hypothalamic pituitary axis symposium speaker, 9th International Congress of Andrology, Barcelona, Spain, March 2009. (Attendance fully paid)

“Conclusions from recent integrated analyses of male hormonal contraception trials”, 12th International Summit Meeting on Hormonal Male Contraception, Barcelona, Spain, March 2009.

“Progress and Prospects for Male hormonal Contraception”, Third Asia-Pacific Forum on Andrology, Nanjing, China, October 2009. (Attendance fully paid)

“Androgens, Obesity and Obstructive Sleep Apnea”, Third Asia-Pacific Forum on Andrology, Nanjing, China, October 2009. (Attendance fully paid)

“Testosterone and Sleep”, Testosterone and Brain Symposium, Special NIDDK anniversary symposium, American Endocrine Society 92nd Annual Meeting, San Diego CA, June 2010. (Registration waived. No other financial compensation, because of Endocrine Society policy on members presenting at the annual scientific meeting)

“Androgens and sleep: bidirectional effects and influence on metabolism”, Chair and symposium speaker, Metabolic and Circadian Hormones in Disrupted Sleep and Sleep Apnea, Associated Professional Sleep Societies 24th Annual Meeting, San Antonio TX, June 2010. This symposium was sponsored by the World Sleep Federation (Registration waived. No other financial compensation, because of APSS Society policy on members presenting at the annual scientific meeting)

Oral Free Communication at International Meeting:

“Predicting pregnancy and spermatogenesis by survival analysis during gonadotropin treatment of gonadotropin deficient infertile men”, President’s Abstract Session, 7th International Congress of Andrology Meeting, Montreal, Canada, June 2001.

“Recombinant hCG, but not DHT alone stimulates osteoblastic collagen synthesis in older men with partial age related androgen deficiency”, 25th American Society for Bone and Mineral Research, Minneapolis, September 2003.

“Correlating androgen and estrogen steroid receptor expression with coronary calcification and atherosclerosis in men without known coronary artery disease”, 30th Annual American Society of Andrology Meeting, Seattle, April, 2005. (Received travel award)

“XXY mice have an osteoporotic phenotype”, 29th American Society for Bone and Mineral Research, Hawaii, September 2007. (Received travel award)

“Karyotypic and Hormonal Control of Gender Preference and Social Behavior of XXY Mice”. 90th American Endocrine Society, San Francisco, June 2008.

“Age attenuates testosterone’s concentration-dependent effects on luteinizing hormone secretory burst mass and number”. 91st American Endocrine Society, Washington DC, June 2009.

“Genetic and Hormonal Control of Bone Volume, Architecture and Histomorphometry in XXY Mice”. 35th Annual American Society of Andrology Meeting, Houston, April 2010. (Received travel award)

“Treatment of Obstructive Sleep Apnoea Reduces Post-Prandial Lipidemia: Evidence from a Randomised, Placebo Controlled Trial of Continuous Positive Airway Pressure”. Late breaking abstract symposium, 24th Annual Meeting of the American Professional Sleep Societies, San Antonio, June 2010. Presented by BJ Yee, on behalf of PY Liu and others).

“Longer-term effects of testosterone therapy on sleep, breathing and body composition in obese men with OSA undergoing weight loss: A randomised placebo controlled trial”, 20th meeting of the European Sleep Research Society, Lisbon, Portugual, September 2010. Presented by C Hoyos, my PhD student, who received an international travel award. I am the senior author.

“Longer-term effects of testosterone therapy on sleep, breathing and body composition in obese men with OSA undergoing weight loss: A randomised placebo controlled trial”. 36th Annual American Society of Andrology Meeting, Montreal, Canada, April 2011.

Invited speaker at a major national meeting:

“The short-term effects of high dose testosterone on sleep in ageing men”, Young Investigator Award Lecture, Endocrine Society of Australia Annual Scientific Meeting, Sydney, August 2004. (Registration waived. No other financial compensation, because of ESA policy on members presenting at the annual scientific meeting)

“Biological Actions of Androgens”, Endocrine Society of Australia Annual Scientific Meeting Satellite Symposium, Gold Coast, August 2006. (No financial compensation, because of ESA policy on members presenting at the annual scientific meeting)

“Androgens and Metabolic Syndrome”, Androgens Use and Abuse Symposium, Andrology Australia Advisory Forum, Adelaide, May 2007. (Attendance fully paid)

“Career Paths in Endocrine Research”, Research Methodology Symposium, Endocrine Society of Australia Annual Seminar Meeting, Sydney, May 2008 (Registration waived. No other financial compensation, because of ESA policy on members presenting at the annual scientific meeting)

“Translating Gonadal Axis Physiology to Clinical Practice”, Rising Stars of Australian Endocrinology Special 50th Anniversary Symposium, Endocrine Society of Australia Annual Scientific Meeting, Melbourne, August 2008. (No financial compensation, because of ESA policy on members presenting at the annual scientific meeting)

“Erectile Dysfunction and Reproductive Health in Men with Diabetes Mellitus”, Sexual Function Symposium, Australian Diabetes Society of Australia Annual Scientific Meeting, Melbourne, August 2008. (Registration waived)

“Induction of Puberty and Spermatogenesis”, Failure of Pubertal Development Symposium, Australian Paediatric Endocrine Group Annual Scientific Meeting, Canberra, November 2008. (Attendance fully paid)

“Testosterone deficiency: its diagnosis and management”, Australian Doctors Education Seminar, University of Sydney, September 2008. (Attendance fully paid)

“Hormones, Sleep and Sleep Disordered Breathing”, Sleep disorders and Circadian Rhythms Symposium, Endocrine Society of Australia Annual Scientific Meeting, Adelaide, August 2009. (No financial compensation, because of ESA policy on members presenting at the annual scientific meeting)

“Age related changes in the regulation of sleep and the male gonadal axis”. Mid-Career Award Lecture, Endocrine Society of Australia Annual Scientific Meeting, Sydney, August 2010. (Registration waived. No financial compensation, because of ESA policy on members presenting at the annual scientific meeting)

“Gonadotropin therapy for male infertility”, Symposium on advancements in the treatment and diagnosis of infertility and other disorders, Fertility Society of Australia Annual Scientific Meeting, Adelaide, October 2010. (Attendance fully paid)

“The Impact of Sleep Loss and Sleep Disturbance on Metabolic Functioning: Mechanisms and Functional Relationships”, Plenary Lecture, Australasian Sleep Association Annual Scientific Meeting, Sydney, October 2011.

Oral Free Communication at National Meeting:

“A randomised placebo controlled clinical trial of recombinant hCG on insulin sensitivity, mood and quality of life in older men”, Endocrine Society of Australia Annual Scientific Meeting, Gold Coast, September 2001. (Received travel award)

“The short-term effects of high dose testosterone on sleep in ageing men”, Endocrine Society of Australia Annual Scientific Meeting, Adelaide, September 2002. (Received travel award)

“Rate, extent and modifiers of spermatogenic recovery after male hormonal contraception: an integrated analysis”, Clinical Investigator Finalist, Endocrine Society of Australia Annual Scientific Meeting, Gold Coast, August 2006.

“Genetic and hormonal control of gender preference and sociability of XXY mice”, Endocrine Society of Australia Annual Scientific Meeting, Melbourne, September 2008.

“Trough serum testosterone levels predict the development of polycythemia (or increased hematocrit) in men with organic androgen deficiency receiving testosterone replacement therapy” (Presented by F Ip; PY Liu is senior author), Endocrine Society of Australia Annual Scientific Meeting, Melbourne, September 2008.

“Assessing hormone secretion during sleep”, Sleep Health session, Australian Sleep Association Annual Scientific Meeting, Adelaide, October 2008.

“Longer-term effects of testosterone therapy on sleep, breathing and body composition in obese men with OSA undergoing weight loss: A randomised placebo controlled 18 week trial”, (Presented by C Hoyos; PY Liu is senior author), Endocrine Society of Australia Annual Scientific Meeting, Sydney, September 2010.

Session chair at international meetings:

Clinical Urology Update Symposium, 32nd Annual American Society of Andrology Meeting, Tampa FL, April 2007

Androgen Use, Misuse and Abuse Symposium, World Association of Sexual Health Conference, Sydney Australia, April 2007

Sleep and Sexual Function Symposium, World Sleep 07, World Congress of the Federation of Sleep Research and Sleep Medicine Societies, Cairns, Australia, September 2007.

Sleep and Hypothalamo-Pituitary-Adrenal System Symposium, World Sleep 07, World Congress of the Federation of Sleep Research and Sleep Medicine Societies, Cairns, Australia, September 2007.

Oral Session Chair, Reproductive Endocrinology Session, 92nd meeting of the US Endocrine Society, San Diego, June 2010.

Metabolic and Circadian Hormones in Disrupted Sleep and Sleep Apnea Symposium, Associated Professional Sleep Societies 24th Annual Meeting, San Antonio TX, June 2010.

Session chair at national Endocrine Society of Australia Annual Scientific meetings:

Sex Steroids Symposium, Gold Coast, September 2001.

Male Reproduction Symposium, Adelaide, September 2002.

Publications

Refereed Journal Articles

1. Liu PY, Turner L, Rushford D, McDonald J, Baker GHW, Conway AJ, Handelsman DJ. Efficacy and safety of recombinant human follicle stimulating hormone (Gonal-F) with urinary human chorionic gonadotrophin for induction of spermatogenesis and fertility in gonadotrophin-deficient men. Human Reproduction 1999; 14:1540-45. (IF=3.773, cit 34) [Role: I analysed the data and prepared the manuscript]

2. Kelleher S, Wishart SM, Liu PY, Turner L, Di Pierro I, Conway AJ, Handelsman DJ. Long-term outcomes of elective human sperm cryostorage. Human Reproduction 2001; 16:2632-9. (IF=3.773, cit 37) [Role: I analysed the data and assisted in preparation of the manuscript]

3. Liu PY, Wishart SM, Handelsman DJ. Randomised, placebo-controlled clinical trial of recombinant human chorionic gonadotropin (hcg) on muscle mass, strength and physical activity in older men. Journal of Clinical Endocrinology and Metabolism 2002; 87: 3125-35. (IF=6.325, cit 39) [Role: I assisted in protocol development, conducted the study, analysed data and prepared the manuscript]

4. Liu PY, Gebski VJ, Turner L, Conway AJ, Wishart S, Handelsman DJ. Predicting pregnancy and spermatogenesis by survival analysis during gonadotropin treatment of gonadotropin deficient infertile men. Human Reproduction 2002; 17: 101-9. (IF=3.773, cit 30) [Role: I developed the protocol, extracted and analysed the data and prepared the manuscript]

5. Ng MKC, Liu PY, Williams A, Nakhla S, Ly LP, Handelsman DJ, Celermajer DS. Prospective study of the effect of androgens on serum inflammatory markers. Arteriosclerosis, Thrombosis and Vascular Biology 2002; 22: 1136-41. (IF=6.858, cit 33) [Role: I conducted one of the clinical studies and assisted in manuscript preparation]

6. Liu PY, Yee B, Wishart SM, Jimenez M, Gun Jung D, Grunstein RR, Handelsman DJ. The short-term effects of high dose testosterone on sleep, breathing and function in older men. Journal of Clinical Endocrinology and Metabolism 2003; 88: 3605-13. (IF=6.325, cit 67) [Role: I co-conceived and wrote the protocol, supervised the study, analysed the data and prepared the manuscript]

7. Liu PY, Wishart SM, Celermajer DS, Di Pierro I, Jimenez M, Conway AJ, Handelsman DJ. Do Reproductive Hormones Modify Insulin Sensitivity and Metabolism in Older Men? A Randomised, Placebo-Controlled Clinical Trial of recombinant human Chorionic Gonadotropin (r-hCG). European Journal of Endocrinology 2003; 148: 55-66. (IF=3.791, cit 38) [Role: I conceived the idea for the study, developed the protocol, conducted the study, analysed the data and prepared the manuscript]

8. Crawford BAL, Liu PY, Kean M, Bleasel J, Handelsman DJ. Randomized placebo-controlled trial of androgen effects on muscle and bone in men requiring long-term systemic glucocorticoid treatment. Journal of Clinical Endocrinology and Metabolism 2003; 88: 3167-76. (IF=6.325, cit 67) [Role: I assisted with protocol development, data analysis and manuscript preparation]

9. Turner L, Jimenez M, Conway AJ, Liu PY, Forbes E, McLachan RI, Handelsman DJ. Contraceptive efficacy of a depot progestin and androgen combination in men. Journal of Clinical Endocrinology and Metabolism 2003; 88: 4659-67. (IF=6.325, cit 65) [Role: I assisted with study conduct and data analysis]

10. Meier C*, Liu PY*, Ly LP, de Winter-Modzelewski J, Jimenez M, Handelsman DJ, Seibel MJ. Recombinant hCG, but not DHT alone stimulates osteoblastic collagen synthesis in older men with partial age related androgen deficiency. Journal of Clinical Endocrinology and Metabolism 2004; 89: 3033-41. *both authors contributed equally to the work. (IF=6.325, cit 12) [Role: I conceived the idea for the analysis, conducted one of the clinical studies, and assisted with data analysis and preparation of the manuscript]

11. Liu PY, Hoey KA, Miekle KL, Veldhuis JD, Khosla S. A randomized placebo-controlled trial of short-term graded transdermal estradiol in healthy GnRH agonist-suppressed pre- and postmenopausal women: Effects on serum markers of bone turnover, IGF-I and osteoclastogenic mediators. Journal of Clinical Endocrinology and Metabolism 2005; 90: 1953-1960. (IF=6.325, cit 3) [Role: I conceived the idea for the study, obtained the samples, performed data analysis and prepared the manuscript]

12. Liu PY, Christian RC, Ruan M, Miller VM, Fitzpatrick LA. Correlating Androgen and Estrogen Steroid Receptor Expression with Coronary Calcification and Atherosclerosis in Men without Known Coronary Artery Disease. Journal of Clinical Endocrinology and Metabolism 2005; 90: 1041-6. (IF=6.325, cit 31) [Role: I conceived the idea for the study, supervised immunohistochemistry, performed data analysis and prepared the manuscript. I am corresponding author.]

13. Liu PY, Takahashi P, Roebuck P, Iranmanesh A, Veldhuis JD. Aging in Healthy Men Impairs Recombinant Human LH-Stimulated Testosterone Secretion Monitored Under a Two-Day Intravenous Pulsatile LH Clamp. Journal of Clinical Endocrinology and Metabolism 2005: 90: 5544-50. (IF=6.325, cit 11) [Role: I supervised and co-conducted the study, performed data analysis and prepared the manuscript]

14. Liu PY, Takahashi P, Roebuck P, Iranmanesh A, Veldhuis JD. Age-Specific Changes in the Regulation of LH-dependent Testosterone Secretion: Assessing Responsiveness to Varying Endogenous Gonadotropin Output in Normal Men. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology 2005: 289: R721-R728. (IF=3.272, cit 4) [Role: I supervised and co-conducted the study, performed data analysis and prepared the manuscript]

15. Liu PY, Pincus SM, Keenan DM, Roelfsema F, Veldhuis JD. Joint Synchrony of Reciprocal Hormonal Signaling in Human Paradigms of Both ACTH Excess and Cortisol Depletion. American Journal of Physiology: Endocrinology and Metabolism 2005: 289:E160-E165. (IF=3.855, cit 8) [Role: I obtained and analysed data, and prepared the manuscript]

16. Takahashi P, Liu PY, Roebuck P, Iranmanesh A, Veldhuis JD. Graded Inhibition of Pulsatile LH Secretion by a Selective GnRH-Receptor Antagonist in Healthy Men: evidence that age attenuates hypothalamic GnRH outflow. Journal of Clinical Endocrinology and Metabolism 2005: 90:2768-2774. (IF=6.325, cit 5) [Role: I co-conducted the study, performed data analysis and assisted in manuscript preparation]

17. Ly LP, Liu PY, Handelsman DJ. Rates of suppression and recovery of human sperm output in testosterone-based hormonal contraceptive regimens. Human Reproduction 2005; 20:1733-1740. (IF=3.773, cit 8) [Role: I assisted in data analysis]

18. Thieben MJ, Blacker DJ, Liu PY, Harper CM, Wijdicks EFM. Pulmonary function tests and blood gases in worsening myasthenia gravis. Muscle & Nerve 2005: 32: 664-667. (IF=2.594, cit 3) [Role: I analysed the data]

19. Liu PY, Pincus SM, Keenan DM, Roelfsema F, Veldhuis JD. Analysis of bidirectional pattern synchrony of concentration-secretion pairs: implementation in the human testicular and adrenal axes. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology 2005; 288: R440-6. (IF=3.272, cit 24) [Role: I obtained and analysed data and prepared the manuscript]

20. Liu PY, Pincus SM, Takahashi PY, Roebuck P, Iranmanesh A, Keenan DM, Veldhuis JD. Aging attenuates both the regularity and joint synchrony of LH and testosterone secretion in normal men: analyses via a model of graded GnRH receptor blockade. Am J Physiol Endocrinol Metab. 2006; 290:E34-E41. (IF=3.855, cit 8) [Role: I co-conducted the study, performed data analysis and prepared the manuscript]

21. Liu PY, Swerdloff RS, Christenson PD, Handelsman DJ, Wang C and the Hormonal Male Contraception Summit group. Rate, extent and modifiers of spermatogenic recovery after male hormonal contraception: an integrated analysis. Lancet 2006; 367: 1412-20. (IF=28.409, cit 21) [Role: I co-conceived the idea for the study, developed the protocol, extracted and analysed the data and prepared the manuscript. I chaired the manuscript writing committee. I am corresponding author]

22. Christian RC, Liu PY, Harrington S, Ruan M, Miller VM, Fitzpatrick LA. Intimal ER(, but not ER( expression is correlated with coronary calcification and atherosclerosis in pre and postmenopausal women. Journal of Clinical Endocrinology and Metabolism 2006: 91: 2713-20. (IF=6.325, cit 32) [Role: I co-conceived the idea for the analysis, performed data analysis and helped prepare the manuscript]

23. Keenan DM, Takahashi PY, Liu PY, Roebuck PD, Nehra AX, Iranmanesh A, Veldhuis JD. An Ensemble Model of the Male Gonadal Axis: illustrative application in aging men. Endocrinology 2006: 147: 2817-28. (IF=5.236, cit 22) [Role: I co-conducted one of the clinical studies]

24. Liu PY, Takahashi P, Roebuck P, Veldhuis JD. Age or Factors Associated with Aging Attenuates Testosterone’s Concentration-Dependent Enhancement of the Regularity of Luteinizing Hormone Secretion in Healthy Men. Journal of Clinical Endocrinology and Metabolism 2006; 91:4077-84. (IF=6.325, cit 6) [Role: I supervised and co-conducted the study, performed data analysis and prepared the manuscript]

25. Carroll BJ, Cassidy F, Naftolowitz D, Tatham NE, Wilson WH, Iranmanesh A, Liu PY, Veldhuis JD. Pathophysiology of hypercortisolism in depression. Acta Psychiatrica Scandinavica 2007; 115 (433):90-103. (IF=3.525, cit 43) [Role: I assisted with data analysis and manuscript preparation]

26. Chung T, Kelleher S, Liu PY, Conway AJ, Kritharides L, Handelsman DJ. Effects of Testosterone and Nandrolone on Cardiac Function: A Randomized, Placebo-Controlled Study. Clinical Endocrinology 2007; 66: 235-45. (IF=3.398, cit 8) [Role: I assisted with data analysis and manuscript preparation]

27. Lue YH, Erkkila K*, Liu PY*, Wang C, Sinha-Hikim A, Swerdloff RS. Fate of bone marrow cells transplanted into the testis. American Journal of Pathology 2007; 170: 899-908. *both authors contributed equally to the work. (IF=5.697, cit 18) [Role: I co-conceived the idea of the study, assisted with protocol development, and helped with microinjections and manuscript preparation]

28. Liu PY, Beilin J, Meier C, Nguyen TV, Center JR, Leedman PJ, Seibel MJ, Eisman JA, Handelsman DJ. Age-related Changes in Serum Testosterone and Sex Hormone Binding Globulin in Australian Men: Longitudinal Analyses of Two Geographically Separate Regional Cohorts. Journal of Clinical Endocrinology and Metabolism 2007; 92: 3599-3603. (IF=6.325, cit 11) [Role: I performed the data analysis, wrote the manuscript preparation and rebuttal]

29. Yee B, Buchanan PR, Mahadev S, Banerjee D, Liu PY, Phillips C, Loughnan G, Steinbeck K, Grunstein RR. Assessment of sleep and breathing in adult Prader-Willi Syndrome subjects: a case control series. Journal of Clinical Sleep Medicine 2007; 3: 714-718. (IF=not listed, cit 3) [Role: I assisted with data analysis, manuscript preparation and rebuttal]

30. Liu PY, Iranmanesh A, Keenan DM, Pincus SM, Veldhuis JD. A non-invasive measure of negative-feedback strength, approximate entropy, unmasks strong diurnal variation in the regularity of luteinizing hormone secretion. Am J Physiol Endocrinol Metab. 2007; 293:E1409-E1415. (IF=3.855, cit 1) [Role: I performed data analysis and prepared the manuscript]

31. Liu PY, Swerdloff RS, Anawalt BD, Anderson RA, Bremner WJ, Elliesen J, Gu YQ, Kersemaekers WM, McLachlan RI, Meriggiola MC, Nieschlag E, Sitruk-Ware R, Vogelsong K, Wang XH, Wu FC, Zitzmann M, Handelsman DJ, Wang C 2008 Determinants of the Rate and Extent of Spermatogenic Suppression during Hormonal Male Contraception: An Integrated Analysis. J Clin Endocrinol Metab 2008; 93:1774-1783. (IF=6.325, cit 5) [Role: I conceived the idea for this analysis, developed the protocol, extracted and analysed the data, and chaired the manuscript writing committee. I am corresponding author]

32. Marshall NS, Wong KKH, Liu PY, Cullen SRJ, Knuiman MW, Grunstein RR. Sleep apnea as an independent risk factor for all-cause mortality: The Busselton Health Study. Sleep 2008; 31: 1079-81. (IF=4.475, cit 67) [Role: I assisted in statistical analysis and critical review of the manuscript]

33. Liu PY, Baker HWG, Jayadev V, Zacharin M, Conway A, Handelsman DJ. Induction of spermatogenesis and fertility during gonadotropin treatment of gonadotropin deficient infertile men: predictors of fertility outcome. Journal of Clinical Endocrinology and Metabolism 2009; 94: 801-8. (IF=6.325, cit 2) [Role: I conceived the idea for this analysis, obtained collaborators, developed the protocol, extracted and analysed the data, and wrote the first draft of the manuscript. I am corresponding author]

34. Marshall NS, Wong KKH, Phillips C, Liu PY, Cullen SRJ, Knuiman MW, Grunstein RR. Is sleep apnea an independent risk factor for prevalent and incident diabetes in the Busselton Health Study? Journal of Clinical Sleep Medicine 2009; 5: 15-20. (IF=not listed, cit 5) [Role: I assisted in statistical analysis and critical review of the manuscript]

35. Kalak R, Zhou H, Street J, Day RE, Modzelewski JR, Spies CM, Liu PY, Li G, Dunstan CR, Seibel MJ. Endogenous glucocorticoid signalling in osteoblasts is necessary to maintain normal bone structure in mice. Bone 2009; 45: 61-67. (IF=4.145, cit 2) [Role: I assisted in statistical analysis].

36. Liu PY, Takahashi PY, Roebuck PD, Bailey J, Keenan DM, Veldhuis JD. Testosterone’s short-term positive effect on luteinizing-hormone secretory-burst mass and its negative effect on luteinizing-hormone secretory-burst number are attenuated in middle-aged men. J Clin Endocrinol Metab 2009; 94: 3978-3986. (IF=6.325, cit 0) [Role: I supervised and co-conducted the study, performed data analysis and prepared the manuscript]

37. Liu PY, Keenan DM, Kok P, Padmanabhan V, O’Bryne KT, Veldhuis JD. Sensitivity and specificity of pulse detection using a novel deconvolution method. Am J Physiol Endocrinol Metab. 2009; 297: E538-44. (IF=3.855, cit 5) [Role: I performed data analysis and prepared the manuscript]

38. Lue YH, Liu PY, Erkkila K, Ma K, Schwarcz M, Wang C, Swerdloff RS. Transplanted XY germ cells produce spermatozoa in testes of XXY mice. International Journal of Andrology 2010; 32: 1-8. [Role: I co-conceived the idea of the study, assisted with protocol development, helped with microinjections, immunohistochemistry and manuscript preparation] (IF=4.021, cit 0) [Role: I assisted in the conception and conduct of the study, study design and reviewed the manuscript]

39. Fennell C, Sartorius G, Ly LP, Turner L, Liu PY, Conway AJ, Handelsman DJ. Randomized cross-over clinical trial of injectable vs. implantable depot testosterone for maintenance of testosterone replacement therapy in androgen deficient men. Clin Endocrinol (Oxf). 2010; 73: 102-9. (IF=3.398, cit 0) [Role: I assisted in protocol development, conduct of the study, analysis and manuscript preparation]

40. Ip F, Di Pierro I, Cunningham I, Brown R, Handelsman DJ, Liu PY. Trough serum testosterone predicts the development of polycythemia in hypogonadal men treated for up to 21 years with subcutaneous testosterone pellets. European Journal of Endocrinology 2010; 162: 385-95. (IF=3.791, cit 1) [Role: I conceived the idea for the study, developed the protocol, conducted the study, supervised the analysis and manuscript. I am the senior and corresponding author]

41. Williams SC, Marshall NS, Kennerson M, Rogers NL, Liu PY, Grunstein RR. Modafinil effects during acute CPAP withdrawal: a randomized crossover double-blind placebo controlled trial. American Journal of Respiratory and Critical Care Medicine 2010; 181: 825-31. (IF=9.091, cit 0) [Role: I co-supervised the first author, who was a PhD student at the time, and now a post-doctoral fellow in my laboratory. I provided day-to-day supervision. I supervised the conduct of the study, analysis and manuscript preparation and rebuttal]

42. Veldhuis JD, Keenan DM, Liu PY, Takahashi PY. Kinetics of removal of intravenous testosterone pulses in normal men. European Journal of Endocrinology 2010; 162: 787-94. (IF=3.791, cit 0) [Role: I contributed to data collection and study design]

43. Liu PY, Kalak R, Lue YH, Jia Y, Erkkila K, Zhou H, Seibel MJ, Wang C, Swerdloff RS, Dunstan CR. Genetic and hormonal control of bone volume, architecture and remodelling in XXY mice. Journal of Bone and Mineral Research 2010; 25: 2148-2154. (IF=6.443, cit 0) [Role: I conceived the idea for study, designed experiments, and processed the majority of specimens. I am corresponding author].

44. Liu PY*, Erkkila K*, Lue YH, Jentsch JD, Dorin Schwarcz M, Abuyounes D, Sinha-Hikim A, Wang C, Lee PWN, Swerdloff RS. Genetic, hormonal and metabolomic influences on social behaviour and gender preference of XXY mice. Am J Physiol Endocrinol Metab 2010; 299: E446-55. (IF=3.855, cit 0) [Role: I conceived the idea for study, designed experiments, and analysed all data. I am corresponding author]. * both authors contributed equally to the work

45. Veldhuis JD, Takahashi PY, Keenan DM, Liu PY, Mielke KL, Weist SM. Age Disrupts Androgen Receptor-Modulated Negative Feedback in the Gonadal Axis in Healthy Men. Am J Physiol Endocrinol Metab 2010: 299: E675-82. (IF=3.855, cit 0) [Role: I contributed to data collection and study design]

Refereed Reviews

1. Handelsman DJ, Liu PY. Androgen therapy in chronic renal failure. Baillieres Clinical Endocrinology and Metabolism 1998; 12: 485-500. (IF=5.225, cit 14)

2. Liu PY, Death AK, Handelsman DJ. Invited Review on Cardiovascular Endocrinology Theme. Androgens and cardiovascular disease. Endocrine Reviews 2003; 24:313-40. (Front cover illustration) (IF=18.562, cit 261)

3. Liu PY, Handelsman DJ. The present and future state of hormonal treatment for male infertility. Human Reproduction Update, 2003; 9:9-23. (IF=6.793, cit 30)

4. Liu PY, Swerdloff RS, Veldhuis JD. The Rationale, Efficacy and Safety of Androgen Therapy in Older Men: Future Research and Current Practice Recommendations. Journal of Clinical Endocrinology and Metabolism 2004; 89:4789-96. (IF=6.325, cit 78. I am corresponding author)

5. Yee B, Liu PY, Phillips C, Grunstein RR. Invited Review. Neuroendocrine Changes in Sleep Apnea. Current Opinion in Pulmonary Medicine 2004; 10: 475-481. (IF=2.475, cit 9)

6. Meier C, Liu PY, Handelsman DJ, Seibel MJ. Invited Review. Endocrine regulation of bone turnover in men. Clinical Endocrinology 2005; 63:603-16. (IF=3.398, cit 19)

7. Liu PY, Iranmanesh A, Nehra AJ, Keenan DM, Veldhuis JD. Invited Review. Mechanisms of Hypoandrogenemia in Healthy Aging Men. Endocrinology and Metabolism Clinics of North America, 2005; 34:935-55. (IF=2.121, cit 10)

8. Liu PY, Swerdloff RS, Wang C. Invited Review. Relative Testosterone Deficiency in Older Men: Clinical Definition and Presentation. Endocrinology and Metabolism Clinics of North America, 2005; 34:957-72. (IF=2.121, cit 4)

9. Handelsman DJ, Liu PY. Invited Review. Andropause: Invention, Prevention, Rejuvenation. Trends in Endocrinology and Metabolism, 2005; 16:39-45. (IF=7.119, cit 27)

10. Liu PY, Yee BJ, Phillips CL, Grunstein RR. Sleep apnea and Neuroendocrine Function. Sleep Medicine Clinics, 2007; 2:225-36. (IF=not yet listed, cit 4)

11. Liu PY, Caterson ID, Grunstein RR, Handelsman DJ. Androgens, Obesity and Sleep Disordered Breathing In Men. Endocrinology and Metabolism Clinics of North America, 2007; 36:349-63. (IF=2.121, cit 1).

12. Brillante R, Yee BJ, Liu PY. Sleep Apnea and Diabetes. Diabetes Management Journal 2008; 24: 26. (IF=not yet listed)

13. Veldhuis JD, Keenan DM, Liu PY, Iranmanesh A, Takahashi PY, Nehra AJ. Invited Review. The Aging Male Hypothalamo-Pituitary-Gonadal Axis: Pulsatility and Feedback. Molecular and Cellular Endocrinology, 2009; 299:14-22. (IF=3.611, cit 3)

14. Liu PY, Swerdloff RS, Wang C. Recent Methodological Advances in Male Hormonal Contraception. Invited Review. Contraception, 2010; 82: 471-475 (IF=2.327, cit 0)

15. Ilani N, Liu PY, Swerdloff RS, Wang C. Does Ethnicity Matter in Male Hormonal Contraceptive Efficacy? Invited review. Special Men’s Health in Asia issue. Asian Journal of Andrology, 2011 in press (accepted 19 Dec 2010).

16. Swerdloff RS, Lue YH, Liu PY, Erkkila K, Wang C. Mouse model for Men with Klinefelter Syndrome: A multifaceted fit for a complex disorder. Acta Paediatrica, 2011 in press (accepted 27 Dec 2010).

17. Lue YH, Wang C, Liu PY, Erkkila K, Swerdloff RS. Insights into the pathogenesis of XXY phenotype from comparison of the clinical syndrome with an experimental XXY mouse model. Paediatric Endocrine Reviews, 2011 in press.

Refereed Book Chapters

1. Liu PY, Handelsman DJ. Androgen therapy in non-gonadal disease. In: Nieschlag E, Behre HM, eds. Testosterone: Action, Deficiency and Substitution, 2nd Edition. Berlin: Springer-Verlag, 1998:473-512. (IF = not listed. cit=7)

2. Liu PY, Handelsman DJ. Androgens and ageing. Current Therapeutics 2001; 42:47-53. (IF = not listed. cit=2)

3. Liu PY, Handelsman DJ. Randomised, placebo-controlled clinical trial of recombinant human chorionic gonadotropin (hcg) on muscle mass, strength and physical activity in older men. Research Summaries Book, American Endocrine Society, 2001.

4. Liu PY, Yee BJ, Wishart SM, Yang QQ, Grunstein RR, Handelsman DJ. The acute effects of high dose testosterone on sleep in ageing men. Research Summaries Book, American Endocrine Society, 2002.

5. Liu PY, Handelsman DJ. Erectile dysfunction. MIMS Disease Index, 2002.

6. Liu PY, Handelsman DJ. Hypogonadism in Men with Chronic Renal Insufficiency. In: Winters SJ, ed. Male Hypogonadism: Basic, Clinical and Therapeutic Principles, 2nd Edition. Totowa: The Humana Press, 2003; Chapter 12: 227-46.

7. Liu PY, Handelsman DJ. Hormonal therapy of the infertile man. In: Meikle A W, ed. Endocrine replacement therapy in clinical practice, 2nd Edition. Totowa: The Humana Press, 2003; Chapter 24: 453-67

8. Liu PY, Handelsman DJ. Androgen therapy in non-gonadal disease. In: Nieschlag E, Behre HM, eds. Testosterone: Action, Deficiency and Substitution, 3rd Edition. Cambridge: Cambridge University Press, 2004; Chapter 15: 445-9. (IF = not listed. cit=4)

9. Meier C, Liu PY, Seibel MJ, Handelsman DJ. Sex steroids and skeletal health in men. In: Lane N, Sambrook P eds. Osteoporosis and the Osteoporosis of Rheumatic Diseases: A companion to Rheumatology. 3rd Edition. Sydney. Elsevier. 2006. Chapter 16: 145-156.

10. Liu PY. Hormonal induction of spermatogenesis in males with hypogonadotropic hypogonadism. In: Kandeel FR, Swerdloff R, Pryor J eds. Male Reproductive Dysfunction: Pathophysiology and treatment. New York: Informa Healthcare USA. 2007. Chapter 30: 337-48.

11. Liu PY, Handelsman DJ. Erectile dysfunction. MIMS Disease Index, 2007.

12. Liu PY, Gooren LJG, Handelsman DJ. Impact of Systemic Disease on Male Sexual Dysfunction In: Kandeel FR, Swerdloff R, Pryor J eds. Male Sexual Dysfunction: Pathophysiology and treatment. New York: Informa Healthcare USA. 2007. Chapter 30: 155-176.

13. Pham A, Liu PY. Erectile Dysfunction. Medical Observer, 8 August 2008, p23-26.

14. Liu PY, Aspres N. Male pattern baldness. Andrology Australia Factsheet 2008. .

15. Liu PY, Takahashi P, Nehra AJ, Pincus SM, Keenan DM, Veldhuis JD. Neuroendocrine aging: Pituitary-testis: LH/FSH/Prolactin. In: Squire LR, Albright TD, Bloom FE, Gage FH, and Spitzer NC eds. Encyclopedia of Neuroscience, volume 6: 317-326. Oxford: Academic Press, 2009.

16. Liu PY, Veldhuis JD. The hypothalamus, pituitary, testes and accessory organs. In: Strauss JF and Barbieri R eds. Yen and Jaffe's Reproductive Endocrinology. 6th Edition. Saunders, 2009. Chapter 12: 283-298.

Refereed Commentary/Editorial

1. Anonymous. Sixth Summit Meeting Consensus: Recommendations for Regulatory Approval for Hormonal Male Contraception. International Journal of Andrology 2002; 25: 375. (IF=4.021, cit 3)

2. Miller VM, Tindall DJ, Liu PY. Invited Editorial. Of mice, men and hormones. Arteriosclerosis, Thrombosis, and Vascular Biology 2004; 24:995-7. (IF=6.858, cit 4)

3. Liu PY, Wang C, Swerdloff RS. Invited Editorial. Male sex matters. Clinical Endocrinology 2005: 63:601-2 (IF=3.398, cit 1)

4. Liu PY, Wang C, Swerdloff RS. Invited Commentary. Does individual response to androgen replacement therapy affect bone density? Nature Clinical Practice: Endocrinology and Metabolism 2006; 2: 76-77. (IF=6.702, cit=0. I am corresponding author)

5. Handelsman DJ, Liu PY. Invited Editorial. Klinefelter's Syndrome--A Microcosm of Male Reproductive Health. Journal of Clinical Endocrinology and Metabolism 2006; 91: 1220-1222. (IF=6.020, cit 7)

6. Liu PY, Handelsman DJ. Invited Commentary. Early markers of metabolic syndrome in nonoverweight, middle-aged men. Nature Clinical Practice Urology 2006; 3: 524-525. (IF=2.874, cit 0. I am corresponding author)

7. Anonymous. Tenth summit meeting consensus: recommendations for regulatory approval for hormonal male contraception. Journal of Andrology 2007; 28:362-363 (IF=2.396, cit 6)

8. Grunstein RR, Phillips C, Liu PY. Invited Editorial. Sleep Apnea – Past, Present and Future. Sleep Med Rev 2008: 12:1-4. (IF=6.143, cit 2)

9. Liu PY, McLachlan RI. Invited Editorial. Male hormonal contraception – so near and yet so far. Journal of Clinical Endocrinology and Metabolism 2008; 93: 2474-2476. (IF=6.020, cit 2. I am corresponding author).

Refereed Conference Papers

1. Liu PY, Exner E, Koutts J, Castaldi PA. Comparison of prothrombin fragment detection methods in thrombosis. Aust NZ J of Med 1993; 23: 120.

2. Liu PY, Turner L, Conway AJ, Wishart S, Handelsman DJ. Evaluation of gonadotrophin replacement therapy to induce spermatogenesis and fertility by survival analysis. Proceedings of Endocrine Society of Australia Annual Scientific Meeting Perth 1998.

3. Handelsman DJ, Liu PY, Turner L, Conway AJ. Gonadotrophin and Other Treatments for Gonadotrophin Deficiency. Proceedings of Clinical Application of Advances in Andrology, Satellite Symposium of Fertility Society of Australia Annual Scientific Meeting, Hobart, October 1998.

4. Liu PY, Handelsman DJ. Randomised, placebo-controlled clinical trial of recombinant human chorionic gonadotropin (hcg) on muscle mass, strength and physical activity in older men. Proceedings American Endocrine Society, 83 rd Annual Meeting, Denver, June 2001.

5. Ng MKC, Williams A, Nakhla S, Liu PY, Ly LP, Handelsman DJ and Celermajer DS. Prospective study of the effect of androgens on serum inflammatory markers. Proceedings of the Cardiac Society of Australia and New Zealand, 2001.

6. Wishart SM, Kelleher S, Di Pierro I, Conway A J, Liu PY, Handelsman DJ. Long-term outcomes of elective human sperm cryostorage. Proceedings of the 7 th International Congress of Andrology, Montreal, Canada, June 2001.

7. Liu PY, Turner L, Conway AJ, Wishart S, Handelsman DJ. Predicting pregnancy and spermatogenesis by survival analysis during gonadotropin treatment of gonadotropin deficient infertile men. Proceedings of the 7 th International Congress of Andrology, Montreal, Canada, June 2001.

8. Turner L, Kelleher S, Wishart SM, Di Pierro I, Liu PY, Conway AJ, Handelsman DJ. Long-term outcomes of elective human sperm cryostorage. Proceedings of Endocrine Society of Australia Annual Scientific Meeting Gold Coast, September, 2001.

9. Liu PY, Wishart SM, Handelsman DJ. A randomised placebo controlled clinical trial of recombinant hCG on insulin sensitivity, mood and quality of life in older men. Proceedings of Endocrine Society of Australia Annual Scientific Meeting Gold Coast, September, 2001.

10. Ng MKC, Liu PY, Williams A, Nakhla S, Ly LP, Handelsman DJ and Celermajer DS. Prospective study of the effect of androgens on serum inflammatory markers. Proceedings of the European Society of Cardiology, Stockholm, September 2001.

11. Crawford B, Liu PY, Kean M, Bleasel J, Handelsman DJ. Androgen therapy in men on longterm glucocorticoids: a 12 month randomised, placebo-controlled trial of testosterone or nandrolone on bone density and body composition. Proceedings of Australian and New Zealand Bone and Mineral Society Annual Scientific Meeting Auckland, October 2001.

12. Turner L, Wishart S, Conway AJ, Liu PY, Forbes E, McLachan RI, Handelsman DJ. Contraceptive efficacy of a depot androgen and progestin combination in men. Proceedings of the 27 th American Society of Andrology Annual Meeting Seattle, April, 2002.

13. Yee BJ, Liu PY, Yang QQ, Wishart SM, Handelsman DJ, Grunstein RR. A double blind, placebo controlled randomised crossover study of intramuscular testosterone esters on sleep in men over 60 years of age. Proceedings of the American Thoracic Society Annual Scientific Meeting, Atlanta, May 2002.

14. Liu PY, Yee BJ, Wishart SM, Yang QQ, Grunstein RR, Handelsman DJ. The acute effects of high dose testosterone on sleep in ageing men. Proceedings American Endocrine Society, 84 th Annual Meeting, San Francisco, June 2002.

15. Turner L, Wishart S, Conway AJ, Liu PY, Forbes E, McLachan RI, Handelsman DJ. Contraceptive efficacy of a depot androgen and progestin combination in men. Proceedings American Endocrine Society, 84 th Annual Meeting, San Francisco, June 2002.

16. Yee BJ, Liu PY, Yang QQ, Wishart SM, Handelsman DJ, Grunstein RR. A double blind, placebo controlled randomised crossover study of intramuscular testosterone esters on sleep in men over 60 years of age. Proceedings of the European Society of Sleep Research, Revjiklavik, Iceland, June 2002.

17. Turner L, Wishart S, Conway AJ, Liu PY, Forbes E, McLachan RI, Handelsman DJ. Contraceptive efficacy of a depot androgen and progestin combination in men. Proceedings of Endocrine Society of Australia Annual Scientific Meeting, Adelaide, September 2002.

18. Liu PY, Yee BJ, Wishart SM, Yang QQ, Grunstein RR, Handelsman DJ. The acute effects of high dose testosterone on sleep in ageing men. Proceedings of Endocrine Society of Australia Annual Scientific Meeting, Adelaide, September 2002.

19. Liu PY. Androgens and Body Composition in Male Ageing. Asian Journal of Andrology 2002; 4 (3 Suppl): 25.

20. Liu PY, Yee BJ, Wishart SM, Yang QQ, Grunstein RR, Handelsman DJ. The acute effects of high dose testosterone on sleep in ageing men. Proceedings of College of Health Sciences, University of Sydney Biannual Scientific Meeting, Leura, September 2002.

21. Meier C, Liu PY, Ly LP, de Winter-Modzelewski J, M. Jimenez M, Handelsman DJ, Seibel MJ. Recombinant hCG, but not DHT Stimulates Osteoblastic Collagen Synthesis in Older Men with Partial Age Related Androgen Deficiency. Proceedings of the American Bone and Mineral Research Society, 25 th Annual Meeting, Minneapolis, September 2003.

22. Thieben MJ, Blacker DJ, Liu PY, Harper CM, Wijdicks EFM. The Value of Pulmonary Function Tests in Predicting Intubation in Myasthenic Crises. Proceedings of the 56 th Annual Meeting of the American Academy of Neurology, San Francisco, April 2004.

23. Liu PY, Keenan DM, Pincus SM, Veldhuis JD. Analysis of nonlinear pattern synchrony of effector concentration-response secretion pairs: implementation in the young and aging human male gonadal axis. Proceedings American Endocrine Society, 86 th Annual Meeting, New Orleans, June 2004.

24. Liu PY, Roelfsema F, Keenan DM, Pincus SM, Veldhuis JD. Pairwise ACTH and cortisol synchrony analyses unveil unequal feedforward-feedback signaling regularity in the older human corticotropic-adrenal axis. Proceedings American Endocrine Society, 86 th Annual Meeting, New Orleans, June 2004.

25. Liu PY, Takahashi P, Roebuck P, Nehra A, Veldhuis JD. Biological nonuniformity of selective GnRH Receptor-blockade of LH secretory-burst mass at any given antagonist concentration in men. Proceedings of the 12 th International Congress of Endocrinology, Lisbon, Portugual, September 2004.

26. Soares-Welch C, Mielke KL, Bradford KA, Mahmud FH, Liu PY, Miles JM, Bowers CY, Veldhuis JD. Heightened responsivity to GHRP-2 and GHRH agonism in the presence of putative somatostatin withdrawal in young women compared with men. Proceedings of the 12 th International Congress of Endocrinology, Lisbon, Portugual, September 2004.

27. Liu PY, Miekle KL, Hoey KA, Veldhuis JD, Khosla S. Low dose estradiol rapidly increases osteoblastic procollagen production in postmenopausal women. Proceedings of the American Bone and Mineral Research Society, 26 th Annual Meeting, Seattle, October 2004.

28. Liu PY, Christian RC, Ruan M, Miller VM, Fitzpatrick LA. Correlating Androgen and Estrogen Steroid Receptor Expression with Coronary Calcification and Atherosclerosis in Men without Known Coronary Artery Disease. Proceedings of the 30 th Annual American Society of Andrology Meeting, Seattle, April, 2005.

29. Liu PY, Pincus SM, Keenan DM, Roelfsema F, Veldhuis JD. Joint synchrony of reciprocal hormonal signaling in human paradigms of both ACTH excess and cortisol depletion. Proceedings American Endocrine Society, 87 th Annual Meeting, San Diego, June 2005.

30. Takahashi P, Liu PY, Roebuck P, Iranmanesh A, Veldhuis JD. Graded Inhibition of Pulsatile LH Secretion by a Selective GnRH-Receptor Antagonist in Healthy Men: evidence that age attenuates hypothalamic GnRH outflow. Proceedings American Endocrine Society, 87 th Annual Meeting, San Diego, June 2005.

31. Liu PY, Swerdloff RS, Christenson PD, Wang C. Recovery of spermatogenesis after androgen-progestin therapy. Western Regional Meeting of the American Federation of Medical Research, Carmel, February 2006.

32. Lue YH, Liu PY, Erkkila K, Wang C, Sinha-Hikim A, Swerdloff RS. Fate of bone marrow cells transplanted into the testis. Proceedings of the 31 st Annual American Society of Andrology Meeting, Chicago, April, 2006.

33. McCrady S, Liu PY, Lanningham-Foster L, Harris A, Foster R, Veldhuis JD, Levine JA. Fidgeting movement in adults: impact of age and obesity. Proceedings of NAASO The Obesity Society Annual Scientific Meeting, Boston, October 2006.

34. Liu PY, Swerdloff RS, Christenson PD, Handelsman DJ, Wang C and the Hormonal Male Contraception Summit group. Rate, extent and modifiers of spermatogenic recovery after male hormonal contraception: an integrated analysis. Proceedings of Endocrine Society of Australia Annual Scientific Meeting, Gold Coast, August 2006.

35. Liu PY, Swerdloff RS, Christenson PD, Handelsman DJ, Wang C and the Hormonal Male Contraception Summit group. Rate, extent and modifiers of spermatogenic recovery after male hormonal contraception: an integrated analysis. Proceedings American Endocrine Society, 88 th Annual Meeting, Boston, June 2006.

36. Liu PY, Takahashi P, Roebuck P, Veldhuis JD. Age Attenuates Testosterone’s Concentration-Dependent Enhancement of the Regularity of Luteinizing Hormone Secretion in Healthy Men. Proceedings American Endocrine Society, 88 th Annual Meeting, Boston, June 2006.

37. Erkkila K, Liu PY, Lee PW-N, Boros LG, Ferrini M, Sinha-Hikim A, Wang C, Lue YH, Swerdloff RS. XXY mice exhibit altered palmitate and stearate metabolism in the brain. Proceedings American Endocrine Society, 88 th Annual Meeting, Boston, June 2006.

38. Lue YH, Liu PY, Ma K, Erkkila K, Sinha-Hikim A, Wang C, Swerdloff RS. Transplanted XY spermatogonia colonise in the seminiferous tubules of XXY mice. Proceedings American Endocrine Society, 88 th Annual Meeting, Boston, June 2006.

39. Schwarcz MD, Liu PY, Erkkila K, Lue YH, Abuyounes D, Jentsch D, Wang C, Swerdloff RS. Gender preference and social behaviour of XXY mice. Proceedings American Endocrine Society, 88 th Annual Meeting, Boston, June 2006.

40. Liu PY, Swerdloff RS, Christenson PD, Handelsman DJ, Wang C and the Hormonal Male Contraception Summit group. Factors Influencing Suppression of Spermatogenesis with Male Hormonal Contraceptive Methods. Proceedings of the 32 nd Annual American Society of Andrology Meeting, Tampa, April, 2007.

41. Liu PY, Iranmanesh A, Keenan DM, Pincus SM, Veldhuis JD. Rapid Transitions in Feedback Control of Gonadotropin and Prolactin in the Morning Hours in Healthy Young Men. Proceedings American Endocrine Society, 89 th Annual Meeting, Toronto, June 2007.

42. Liu PY, Kalak R, Lue YH, Erkkila K, Simanainen U, Zhou H, Syed F, Hikim AP, Handelsman DJ, Seibel MJ, Wang C, Swerdloff RS, Dunstan CR. XXY Mice have an Osteoporotic Phenotype. Proceedings of the American Bone and Mineral Research Society, 29 th Annual Meeting, Honolulu, September 2007.

43. Ong CR, Ipavec-Levasseur D, Cowin G, Liu PY, O’Moore Sullivan TM and Prins JB. Androgen Replete Obese Men are More Insulin Sensitive, Store Less Intramyocellular Lipids and have Less Intramyocellular Lipids for Use in Acute Exercise. European Congress of Obesity, Geneva, May 2008

44. Ong CR, Lai J, Lloyd T, Liu PY, O’Moore Sullivan TM and Prins JB. Clinically Achievable Weight Loss Improves Symptoms of Androgen Deficiency but does not increase Androgen Bioactivity or Testosterone Concentrations in Obese Men. European Congress of Obesity, Geneva, May 2008

45. Liu PY, Swerdloff RS, Handelsman DJ, Wang C and the Hormonal Male Contraception Summit group. Determinants of the Rate and Extent of Spermatogenic Suppression during Hormonal Male Contraception. Proceedings American Endocrine Society, 90th Annual Meeting, San Francisco, June 2008.

46. Erkkila K*, Liu PY*, Lue YH, Schwarcz MD, Abuyounes D, Ruiz R, Ma K, Jentsch JD, Wang C, Swerdloff RS. Karyotypic and Hormonal Control of Gender Preference and Social Behavior of XXY Mice. Proceedings American Endocrine Society, 90th Annual Meeting, San Francisco, June 2008. *Contributed equally to the work

47. Marshall NS, Wong KKH, Liu PY, Cullen SRJ, Knuiman MW, Grunstein RR. Sleep apnea as an independent risk factor for incident diabetes and metabolic syndrome: Proceedings Associated Professional Sleep Societies 22nd Annual Meeting, Baltimore, June 2008.

48. Kalak R, Street J, Day RE, Modzelewski JRK, Liu PY, Li G, Dunstan CR, Zhou H, Seibel MJ. Glucocorticoid Signaling in Osteoblasts Maintains Normal Bone Structure in Mice. Proceedings of the American Bone and Mineral Research Society, 30 th Annual Meeting, Montreal, Canada, September 2008.

49. Liu PY*, Erkkila K*, Jentsch JD, Lue YH, Schwarcz MD, Abuyounes D, Wang C, Swerdloff RS. Genetic and hormonal control of gender preference and sociability of XXY mice. Proceedings of the Endocrine Society of Australia Annual Scientific Meeting, Melbourne, August 2008. *Contributed equally to the work.

50. Ip F, Handelsman DJ, Liu PY. Trough serum testosterone levels predict the development of polycythemia in men with organic androgen deficiency receiving testosterone replacement therapy. Proceedings of the Endocrine Society of Australia Annual Scientific Meeting, Melbourne, August 2008.

51. Fennell C, Ly LP, Turner L. Liu PY, Conway AJ, Handelsman DJ. Pharmacokinetics sand pharmacodynamics of depot testosterone: randomised cross-over trial of injectable vs implantable testosterone in androgen deficient men. Proceedings of the Endocrine Society of Australia Annual Scientific Meeting, Melbourne, August 2008.

52. Liu PY, Keenan DM, Veldhuis JD. Assessing hormone secretion during sleep. Sleep and Biological Rhythms, October 2008, 6: Supplement 1: A17.

53. Marshall NS, Wong KKH, Liu PY, Cullen SRJ, Knuiman MW, Grunstein RR. Sleep apnea as an independent risk factor for all-cause mortality in a community-based cohort: The Busselton Health Study. Sleep and Biological Rhythms, October 2008, 6: Supplement 1: A12.

54. Marshall NS, Wong KKH, Liu PY, Cullen SRJ, Knuiman MW, Grunstein RR. Sleep apnea as an independent risk factor for incident diabetes and metabolic syndrome: The Busselton Health Study. Sleep and Biological Rhythms, October 2008, 6: Supplement 1: A39.

55. Liu PY, Baker HWG, Jayadev V, Conway A, Handelsman DJ. Induction of spermatogenesis and fertility during gonadotropin treatment of gonadotropin deficient infertile men: clues to improving fertility outcome. Proceedings of the 34th Annual American Society of Andrology Meeting, Pennsylvannia, April, 2009.

56. Veldhuis JD, Liu PY, Takahashi P, Keenan DM. Pulses of Testosterone Enforce Negative Feedback in Healthy Men: feedback modulation by age, body-mass index and sex-hormone binding globulin. Proceedings American Endocrine Society, 91st Annual Meeting, Washington DC, June 2009.

57. Liu PY, Takahashi PY, Roebuck PD, Bailey J, Keenan DM, Veldhuis JD. Age attenuates testosterone’s concentration-dependent effects on luteinizing hormone secretory burst mass and number. Proceedings American Endocrine Society, 91st Annual Meeting, Washington DC, June 2009.

58. Williams SC, Marshall NS, Rogers NL, Liu PY, Grunstein RR. Modafinil effects during acute CPAP withdrawal: a randomized crossover double-blind placebo controlled trial. Proceedings of the American Professional Sleep Societies, 23rd Annual Meeting, Seattle, June 2009.

59. Handelsman DJ, Idan A, Griffiths K, Liu PY, Seibel MJ, Turner L, Conway AJ. Randomized Placebo-Controlled Clinical Trial of Transdermal Dihydrotestosterone (DHT) Gel Does Not Influence Prostate Growth Rate and Reduces Spinal but Not Hip Bone Density. Proceedings American Endocrine Society, 91st Annual Meeting, Washington DC, June 2009.

60. Nehra A, Veldhuis JD, Takahashi PY, Liu PY, Bailey J. Abdominal visceral adiposity and age individually and jointly determine LH-T feedforward and T-LH feedback synchrony in men. Journal of Andrology 2009: 30; March/April Supplement: 103.

61. Liu PY, Takahashi PY, Roebuck PD, Bailey J, Keenan DM, Veldhuis JD. Testosterone’s short-term positive effect on luteinizing hormone secretory burst mass and its negative effect on secretory burst frequency are attenuated in middle-aged men. Proceedings of the Endocrine Society of Australia Annual Scientific Meeting, Adelaide, August 2009.

62. Veldhuis JD, Takahashi P, Keenan DM, Liu PY, Mielke KL, Weist SM. Mechanisms of androgen receptor-modulated negative feedback on gonadal axis in healthy men. Proceedings American Endocrine Society, 92nd Annual Meeting, San Diego, June 2010.

63. Ong CR, Franklin ME, Taylor PJ, Galligan JP, Baker PJ, Liu PY, O’Moore-Sullivan TM, Prins JB. Diagnosis of hypogonadism in obese males: more complex than we thought? Proceedings American Endocrine Society, 92nd Annual Meeting, San Diego, June 2010.

64. Grunstein L, Liu PY, Richmond JL. Effects of Sleep on Gross Motor, Fine Motor and Serial Order Memory. Proceedings of the American Professional Sleep Societies, 24th Annual Meeting, San Antonio, June 2010.

65. Phillips CL, Yee BJ, Marshall NS, Liu PY, Sullivan DR, Grunstein RR Treatment of Obstructive Sleep Apnoea Reduces Post-Prandial Lipidemia: Evidence from a Randomised, Placebo Controlled Trial of Continuous Positive Airway Pressure. Proceedings of the American Professional Sleep Societies, 24th Annual Meeting, San Antonio, June 2010.

66. Ong CR, Franklin ME, Taylor PJ, Galligan JP, Baker PJ, Liu PY, O’Moore-Sullivan TM, Prins JB. Complexities of diagnosing hypogonadism in obese males. Proceedings International Congress of Obesity, 11th Quadrannial Meeting, Stockholm, Sweden, July 2010.

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